Y Matsui

Summary

Affiliation: Tohoku University
Country: Japan

Publications

  1. doi request reprint The majority of early primordial germ cells acquire pluripotency by AKT activation
    Yasuhisa Matsui
    Cell Resource Center for Biomedical Research, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Miyagi 980 8575, Japan CREST, JST, Kawaguchi, Saitama 332 0012, Japan
    Development 141:4457-67. 2014
  2. pmc Implication of DNA demethylation and bivalent histone modification for selective gene regulation in mouse primordial germ cells
    Kentaro Mochizuki
    Cell Resource Center for Biomedical Research, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    PLoS ONE 7:e46036. 2012
  3. ncbi request reprint A receptor tyrosine kinase, Sky, and its ligand Gas 6 are expressed in gonads and support primordial germ cell growth or survival in culture
    N Matsubara
    Department of Cell Biology, Institute of Development, Aging, and Cancer, Tohoku University, 4 1 Seiryo machi, Sendai, 980, Japan
    Dev Biol 180:499-510. 1996
  4. doi request reprint The molecular mechanisms regulating germ cell development and potential
    Yasuhisa Matsui
    Cell Resource Center for Biomedical Research, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Miyagi 980 8575, Japan
    J Androl 31:61-5. 2010
  5. doi request reprint Primordial germ cells contain subpopulations that have greater ability to develop into pluripotential stem cells
    Yasuhisa Matsui
    Cell Resource Center for Biomedical Research, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Miyagi 980 8575, Japan
    Dev Growth Differ 51:657-67. 2009
  6. ncbi request reprint Epigenetic regulation for the induction of meiosis
    Y Matsui
    Cell Resource Center for Biomedical Research, Institute of Development, Aging and Cancer, Tohoku University, Seiryo machi 4 1, Sendai 980 8575, Japan
    Cell Mol Life Sci 64:257-62. 2007
  7. ncbi request reprint A novel serine/threonine kinase gene, Gek1, is expressed in meiotic testicular germ cells and primordial germ cells
    M Yanagisawa
    Department of Cell Biology, Tohoku University, Sendai, Japan
    Mol Reprod Dev 45:411-20. 1996
  8. ncbi request reprint Bcl-2 inhibits apoptosis of spermatogonia and growth of spermatogonial stem cells in a cell-intrinsic manner
    N Sugiyama
    Department of Cell Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Miyagi, Japan
    Mol Reprod Dev 58:30-8. 2001
  9. ncbi request reprint Inhibition of testicular germ cell apoptosis and differentiation in mice misexpressing Bcl-2 in spermatogonia
    T Furuchi
    Department of Cell Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    Development 122:1703-9. 1996
  10. ncbi request reprint Murine polo like kinase 1 gene is expressed in meiotic testicular germ cells and oocytes
    N Matsubara
    Department of Cell Biology, Tohoku University, Sendai, Japan
    Mol Reprod Dev 41:407-15. 1995

Collaborators

Detail Information

Publications36

  1. doi request reprint The majority of early primordial germ cells acquire pluripotency by AKT activation
    Yasuhisa Matsui
    Cell Resource Center for Biomedical Research, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Miyagi 980 8575, Japan CREST, JST, Kawaguchi, Saitama 332 0012, Japan
    Development 141:4457-67. 2014
    ..These findings indicate that AKT signal enhances and/or collaborates with signaling pathways of bFGF and of LIF in PGCs for the acquisition of pluripotency...
  2. pmc Implication of DNA demethylation and bivalent histone modification for selective gene regulation in mouse primordial germ cells
    Kentaro Mochizuki
    Cell Resource Center for Biomedical Research, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    PLoS ONE 7:e46036. 2012
    ..Our results indicated that epigenetic status of PGC genes and of somatic genes in PGCs were distinct, and suggested contribution of epigenetic mechanisms in regulation of the expression of a specific gene set in PGCs...
  3. ncbi request reprint A receptor tyrosine kinase, Sky, and its ligand Gas 6 are expressed in gonads and support primordial germ cell growth or survival in culture
    N Matsubara
    Department of Cell Biology, Institute of Development, Aging, and Cancer, Tohoku University, 4 1 Seiryo machi, Sendai, 980, Japan
    Dev Biol 180:499-510. 1996
    ..The results suggest that signals from differentiated germ cells suppress Sky gene expression in Sertoli cells. High-resolution chromosomal mapping of Sky is also reported...
  4. doi request reprint The molecular mechanisms regulating germ cell development and potential
    Yasuhisa Matsui
    Cell Resource Center for Biomedical Research, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Miyagi 980 8575, Japan
    J Androl 31:61-5. 2010
    ..Once they have undergone specification and differentiation, PGCs normally give rise to gametes, but they maintain the potential to be converted into pluripotential stem cells upon activation of particular signaling pathways...
  5. doi request reprint Primordial germ cells contain subpopulations that have greater ability to develop into pluripotential stem cells
    Yasuhisa Matsui
    Cell Resource Center for Biomedical Research, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Miyagi 980 8575, Japan
    Dev Growth Differ 51:657-67. 2009
    ..Thus, conversion of PGCs into pluripotential stem cells may be regulated by being influenced by the natural status of individual PGCs as well as the reprogramming process after starting culture...
  6. ncbi request reprint Epigenetic regulation for the induction of meiosis
    Y Matsui
    Cell Resource Center for Biomedical Research, Institute of Development, Aging and Cancer, Tohoku University, Seiryo machi 4 1, Sendai 980 8575, Japan
    Cell Mol Life Sci 64:257-62. 2007
    ....
  7. ncbi request reprint A novel serine/threonine kinase gene, Gek1, is expressed in meiotic testicular germ cells and primordial germ cells
    M Yanagisawa
    Department of Cell Biology, Tohoku University, Sendai, Japan
    Mol Reprod Dev 45:411-20. 1996
    ..We also show that Gek1 locates on chromosome 11, near the wr locus, showing neuronal and reproductive defects...
  8. ncbi request reprint Bcl-2 inhibits apoptosis of spermatogonia and growth of spermatogonial stem cells in a cell-intrinsic manner
    N Sugiyama
    Department of Cell Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Miyagi, Japan
    Mol Reprod Dev 58:30-8. 2001
    ....
  9. ncbi request reprint Inhibition of testicular germ cell apoptosis and differentiation in mice misexpressing Bcl-2 in spermatogonia
    T Furuchi
    Department of Cell Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    Development 122:1703-9. 1996
    ..These observations indicate that spermatogonial apoptosis is part of the normal program of mammalian spermatogenesis and is regulated by a pathway affected by Bcl-2...
  10. ncbi request reprint Murine polo like kinase 1 gene is expressed in meiotic testicular germ cells and oocytes
    N Matsubara
    Department of Cell Biology, Tohoku University, Sendai, Japan
    Mol Reprod Dev 41:407-15. 1995
    ..The pattern of expression of the Plk1 gene suggests that the gene product is involved in completion of meiotic division, and like the Drosophila polo protein, is a maternal factor active in embryos at the early cleavage stage...
  11. ncbi request reprint Apoptosis of fetal testicular cells is regulated by both p53-dependent and independent mechanisms
    Y Matsui
    Department of Cell Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Miyagi, Japan
    Mol Reprod Dev 55:399-405. 2000
    ..In contrast, a similar number of apoptotic cells was found in fetal ovaries throughout these developmental stages. These observations indicate that p53 promotes apoptosis of fetal testicular cells after 16.5 dpc...
  12. ncbi request reprint Members of the ErbB receptor tyrosine kinases are involved in germ cell development in fetal mouse gonads
    H Toyoda-Ohno
    Department of Cell Biology, Institute of Development, Aging, and Cancer, Tohoku University, 4 1, Seiryo machi, Sendai, Miyagi, 980 8575, Japan
    Dev Biol 215:399-406. 1999
    ..In addition, a recombinant Neuregulin-beta enhanced the number of PGCs in 12.5-dpc embryos in culture. Taken together, these observations suggest that ErbB signaling controls the growth or survival of PGCs in genital ridges...
  13. ncbi request reprint Regulation of germ cell death in mammalian gonads
    Y Matsui
    Department of Cell Biology, Tohoku University, Japan
    APMIS 106:142-7; discussion 147-8. 1998
    ..This suggests that germ cell survival or death at each stage of differentiation is precisely controlled by specific signalling pathways which consist of a number of molecules...
  14. ncbi request reprint Molecular cloning and expression of mouse mg(2+)-dependent protein phosphatase beta-4 (type 2C beta-4)
    S Kato
    Department of Biochemistry, Tohoku University, Sendai, Japan
    Arch Biochem Biophys 318:387-93. 1995
    ..These results suggest that the complex structure of MPP beta isoforms and their tissue- and developmental stage-specific expression reflect the variety of their physiological functions...
  15. ncbi request reprint Developmental fates of the mouse germ cell line
    Y Matsui
    Department of Cell Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    Int J Dev Biol 42:1037-42. 1998
    ....
  16. ncbi request reprint Cloning of a housekeeping-type gene (MER5) preferentially expressed in murine erythroleukemia cells
    T Yamamoto
    Department of Cell Biology, Tohoku University, Sendai, Japan
    Gene 80:337-43. 1989
    ..More interestingly, this promoter contained the duplicated CACCC boxes, which are common in the adult beta-globin promoter from many species, but uncommon for promoters of other eukaryotic genes...
  17. ncbi request reprint Structural organization of the mouse glycophorin A gene
    M Terajima
    Department of Cell Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai
    J Biochem 116:1105-10. 1994
    ..The upstream regulatory region of the mouse gene consists of multiple motifs for DNA binding factors that may be required for its erythroid-specific expression...
  18. ncbi request reprint Expression and intracellular localization of mouse Vasa-homologue protein during germ cell development
    Y Toyooka
    Mitsubishi Kasei Institute of Life Sciences, 11 Minami Ooya, Machida, Tokyo, Japan
    Mech Dev 93:139-49. 2000
    ....
  19. ncbi request reprint Effects of p53 mutations on cellular sensitivity to ionizing radiation
    Y Matsui
    Department of Radiation Oncology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Am J Clin Oncol 24:486-90. 2001
    ..Our results suggest that mutant forms of p53 represent a phenotype that affects the radiation sensitivity and is not dependent on the apoptotic pathway...
  20. ncbi request reprint Cytoprotective effect of hepatic cell pretreatment with 15-deoxyspergualin to prevent warm ischemic reperfusion injuries in rats
    Y Matsui
    Department of Surgery II, Chiba University School of Medicine, Chiba, Japan
    Transplant Proc 34:2674-6. 2002
  21. ncbi request reprint Analysing mass balance of viruses in a coagulation-ceramic microfiltration hybrid system by a combination of the polymerase chain reaction (PCR) method and the plaque forming units (PFU) method
    T Matsushita
    Dept Civil Eng, Gifu Univ, Japan
    Water Sci Technol 53:199-207. 2006
    ..The combination of the PCR and PFU methods revealed that two phenomena, adsorption to/entrapment in aluminium floc and virucidal activity of PACI, partially account for the high virus removal in the coagulation-MF hybrid system...
  22. pmc Sro7p, a Saccharomyces cerevisiae counterpart of the tumor suppressor l(2)gl protein, is related to myosins in function
    M Kagami
    Department of Biological Sciences, Graduate School of Science, University of Tokyo, Tokyo 113, Japan
    Genetics 149:1717-27. 1998
    ..These results indicate that Sro7 function is closely related to both Myo1p and Myo2p. We propose a model in which Sro7 function is involved in the targeting of the myosin proteins to their intrinsic pathways...
  23. ncbi request reprint Phosphoinositide-specific phospholipase C forms a complex with 14-3-3 proteins and is involved in expression of UV resistance in fission yeast
    T Andoh
    Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Japan
    Mol Gen Genet 258:139-47. 1998
    ..Thus, Plc1p is responsible for resistance to UV irradiation, but not for the DNA damage checkpoint pathway, in cooperation with 14-3-3 proteins...
  24. pmc Molecular cloning and characterization of a novel type of regulatory protein (GDI) for smg p25A, a ras p21-like GTP-binding protein
    Y Matsui
    Research Center, Mitsubishi Kasei Corporation, Yokohama, Japan
    Mol Cell Biol 10:4116-22. 1990
    ..This fact has raised the possibility that smg p25A GDI interacts with another G protein in tissues in which smg p25A is absent...
  25. ncbi request reprint Complementary DNA cloning of the murine transforming growth factor-beta 3 (TGF beta 3) precursor and the comparative expression of TGF beta 3 and TGF beta 1 messenger RNA in murine embryos and adult tissues
    D A Miller
    Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232
    Mol Endocrinol 3:1926-34. 1989
    ..5-17.5 days postcoitum, with higher levels observed in the latter stages. The differential expression of these TGF beta genes suggests that the various TGF beta species may have distinct physiological roles in vivo...
  26. ncbi request reprint Isolation of the cDNA clone for mouse glycophorin, erythroid-specific membrane protein
    Y Matsui
    Faculty of Pharmaceutical Sciences, University of Tokyo, Japan
    Gene 77:325-32. 1989
    ..The glycophorin mRNA is absent in all non-erythroid organs or cell lines examined. The glycophorin mRNA is induced during the differentiation of murine erythroleukemia cells with dimethyl sulfoxide...
  27. ncbi request reprint Isolation and characterization of temperature-sensitive plc1 mutants of the yeast Saccharomyces cerevisiae
    T Yoko-o
    Department of Plant Sciences, Graduate School of Science, University of Tokyo, Japan
    Mol Gen Genet 247:148-56. 1995
    ..At the restrictive temperature, plc1 mutant cells ceased growth at random times during the cell cycle, a result that suggests that PLC1 is required at several or all stages of the cell cycle...
  28. ncbi request reprint Isolation of a CDC25 family gene, MSI2/LTE1, as a multicopy suppressor of ira1
    M Shirayama
    Department of Biology, Faculty of Science, University of Tokyo, Japan
    Yeast 10:451-61. 1994
    ..These results suggest that MSI2 is involved in the termination of M phase and that this process is regulated by a ras superfamily gene product...
  29. ncbi request reprint MSI3, a multicopy suppressor of mutants hyperactivated in the RAS-cAMP pathway, encodes a novel HSP70 protein of Saccharomyces cerevisiae
    M Shirayama
    Department of Biology, Faculty of Science, University of Tokyo, Japan
    Mol Gen Genet 240:323-32. 1993
    ..Disruption of the MSI3 gene was associated with a temperature sensitive growth phenotype but unexpectedly, thermotolerance was enhanced in the disruptant...
  30. pmc Yeast src homology region 3 domain-binding proteins involved in bud formation
    Y Matsui
    Department of Biological Sciences, Graduate School of Science, University of Tokyo, Japan
    J Cell Biol 133:865-78. 1996
    ..Overproduction of either Rho3p or the Rho3p-related GTPase Rho4p suppressed the boi defect. These results demonstrate that Rho3p GTPases and Boi proteins function in the maintenance of cell polarity for bud formation...
  31. pmc Identification of the bud emergence gene BEM4 and its interactions with rho-type GTPases in Saccharomyces cerevisiae
    D Mack
    Department of Biology, Indiana University, Bloomington 47405, USA
    Mol Cell Biol 16:4387-95. 1996
    ..Models for the role of Bem4p include that it serves as a chaperone or modulates the interaction of these GTPases with one or more of their targets or regulators...
  32. pmc Separable cis-regulatory elements that contribute to tissue- and site-specific alpha 2(XI) collagen gene expression in the embryonic mouse cartilage
    N Tsumaki
    Department of Orthopaedic Surgery, Osaka University Medical School, Suita, Japan
    J Cell Biol 134:1573-82. 1996
    ..In addition, our observations suggest the presence of site-specific cis-acting elements that control Coll11a2 gene expression in different cartilaginous components of the skeleton...
  33. ncbi request reprint Assignment of the murine protein kinase gene DLK to chromosome 15 in the vicinity of the bt/Koa locus by genetic linkage analysis
    T Watanabe
    Department of Molecular Information, Tokyo University, Japan
    Genomics 40:375-6. 1997
  34. pmc SRO9, a multicopy suppressor of the bud growth defect in the Saccharomyces cerevisiae rho3-deficient cells, shows strong genetic interactions with tropomyosin genes, suggesting its role in organization of the actin cytoskeleton
    M Kagami
    Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Hongo, Japan
    Genetics 147:1003-16. 1997
    ..Unlike tropomyosin, Sro9p does not colocalize with actin cables but is diffusely cytoplasmic. These results suggest that Sro9p is a new cytoplasmic factor involved in the organization of actin filaments...
  35. ncbi request reprint Differential in situ expression of alpha2(XI) collagen mRNA isoforms in the developing mouse
    M Sugimoto
    Department of Orthopaedic Surgery, Osaka University Medical School, 2 2 Yamadaoka, Suita 565, Japan
    Cell Tissue Res 292:325-32. 1998
    ..In addition, alpha2(XI) mRNA isoforms containing alternative exons are present in osteogenic cells, and their expression may be closely related to the formation of bone or cartilage...
  36. ncbi request reprint Isolation and characterization of two novel ras superfamily genes in Saccharomyces cerevisiae
    Y Matsui
    Department of Biology, University of Tokyo, Japan
    Gene 114:43-9. 1992
    ....