Yukitsuka Kudo

Summary

Affiliation: Tohoku University
Country: Japan

Publications

  1. ncbi request reprint In vivo labeling of amyloid with BF-108
    Takahiro Suemoto
    Research Department, BF Research Institute, c o National Cardiovascular Center, 7 1, 5 Chome, Fujishiro dai, Suita, Osaka 565 0873, Japan
    Neurosci Res 48:65-74. 2004
  2. ncbi request reprint A novel imaging probe for in vivo detection of neuritic and diffuse amyloid plaques in the brain
    Nobuyuki Okamura
    BF Research Institute, c o National Cardiovascular Center, Fujishiro dai, Suita, Osaka, Japan
    J Mol Neurosci 24:247-55. 2004
  3. ncbi request reprint Development of amyloid imaging PET probes for an early diagnosis of Alzheimer's disease
    Yukitsuka Kudo
    Tohoku University Biomedical Engineering Research Organization TUBERO, Sendai, Japan
    Minim Invasive Ther Allied Technol 15:209-13. 2006
  4. ncbi request reprint Styrylbenzoazole derivatives for imaging of prion plaques and treatment of transmissible spongiform encephalopathies
    Kensuke Ishikawa
    Division of Prion Biology, Department of Prion Research, Tohoku University Graduate School of Medicine, Sendai, Japan
    J Neurochem 99:198-205. 2006
  5. ncbi request reprint 2-(2-[2-Dimethylaminothiazol-5-yl]ethenyl)-6- (2-[fluoro]ethoxy)benzoxazole: a novel PET agent for in vivo detection of dense amyloid plaques in Alzheimer's disease patients
    Yukitsuka Kudo
    Tohoku University Biomedical Engineering Research Organization, Sendai, Japan
    J Nucl Med 48:553-61. 2007
  6. ncbi request reprint [Probes for diagnosis of Alzheimer's disease]
    Yukitsuka Kudo
    Nihon Yakurigaku Zasshi 126:199-206. 2005
  7. doi request reprint In vivo detection of prion amyloid plaques using [(11)C]BF-227 PET
    Nobuyuki Okamura
    Department of Pharmacology, Tohoku University School of Medicine, Sendai, Japan
    Eur J Nucl Med Mol Imaging 37:934-41. 2010
  8. doi request reprint Comparison of the binding characteristics of [18F]THK-523 and other amyloid imaging tracers to Alzheimer's disease pathology
    Ryuichi Harada
    Department of Pharmacology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, Japan
    Eur J Nucl Med Mol Imaging 40:125-32. 2013
  9. doi request reprint Comparison study of amyloid PET and voxel-based morphometry analysis in mild cognitive impairment and Alzheimer's disease
    Masaaki Waragai
    Department of Geriatrics and Gerontology, Division of Brain Sciences, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    J Neurol Sci 285:100-8. 2009
  10. doi request reprint A 18F-labeled BF-227 derivative as a potential radioligand for imaging dense amyloid plaques by positron emission tomography
    Shozo Furumoto
    Department of Pharmacology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, 980 8575, Japan
    Mol Imaging Biol 15:497-506. 2013

Collaborators

Detail Information

Publications29

  1. ncbi request reprint In vivo labeling of amyloid with BF-108
    Takahiro Suemoto
    Research Department, BF Research Institute, c o National Cardiovascular Center, 7 1, 5 Chome, Fujishiro dai, Suita, Osaka 565 0873, Japan
    Neurosci Res 48:65-74. 2004
    ..These properties suggest the potential utility of BF-108 for in vivo imaging of AD pathology...
  2. ncbi request reprint A novel imaging probe for in vivo detection of neuritic and diffuse amyloid plaques in the brain
    Nobuyuki Okamura
    BF Research Institute, c o National Cardiovascular Center, Fujishiro dai, Suita, Osaka, Japan
    J Mol Neurosci 24:247-55. 2004
    ..These findings suggest that BF-145 is a potential candidate as a probe for imaging early brain pathology in AD patients...
  3. ncbi request reprint Development of amyloid imaging PET probes for an early diagnosis of Alzheimer's disease
    Yukitsuka Kudo
    Tohoku University Biomedical Engineering Research Organization TUBERO, Sendai, Japan
    Minim Invasive Ther Allied Technol 15:209-13. 2006
    ..Currently, we have investigated the clinical trial of [11C]BF-227 in healthy subjects and AD patients...
  4. ncbi request reprint Styrylbenzoazole derivatives for imaging of prion plaques and treatment of transmissible spongiform encephalopathies
    Kensuke Ishikawa
    Division of Prion Biology, Department of Prion Research, Tohoku University Graduate School of Medicine, Sendai, Japan
    J Neurochem 99:198-205. 2006
    ..The compounds were BBB permeable and non-toxic at doses for imaging and treatment; therefore, they are expected to be of practical use in human TSE...
  5. ncbi request reprint 2-(2-[2-Dimethylaminothiazol-5-yl]ethenyl)-6- (2-[fluoro]ethoxy)benzoxazole: a novel PET agent for in vivo detection of dense amyloid plaques in Alzheimer's disease patients
    Yukitsuka Kudo
    Tohoku University Biomedical Engineering Research Organization, Sendai, Japan
    J Nucl Med 48:553-61. 2007
    ..This study reports a novel compound, 2-(2-[2-dimethylaminothiazol-5-yl]ethenyl)-6-(2-[fluoro]ethoxy)benzoxazole (BF-227), for in vivo detection of dense amyloid deposits using PET...
  6. ncbi request reprint [Probes for diagnosis of Alzheimer's disease]
    Yukitsuka Kudo
    Nihon Yakurigaku Zasshi 126:199-206. 2005
  7. doi request reprint In vivo detection of prion amyloid plaques using [(11)C]BF-227 PET
    Nobuyuki Okamura
    Department of Pharmacology, Tohoku University School of Medicine, Sendai, Japan
    Eur J Nucl Med Mol Imaging 37:934-41. 2010
    ..The purpose of this study is to evaluate the amyloid imaging tracer BF-227 with positron emission tomography (PET) for the non-invasive detection of PrP amyloid in the brain...
  8. doi request reprint Comparison of the binding characteristics of [18F]THK-523 and other amyloid imaging tracers to Alzheimer's disease pathology
    Ryuichi Harada
    Department of Pharmacology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, Japan
    Eur J Nucl Med Mol Imaging 40:125-32. 2013
    ..The purpose of this study was to compare the binding properties of [(18)F]THK-523 and other amyloid imaging agents, including PiB, BF-227 and FDDNP, to synthetic protein fibrils and human brain tissue...
  9. doi request reprint Comparison study of amyloid PET and voxel-based morphometry analysis in mild cognitive impairment and Alzheimer's disease
    Masaaki Waragai
    Department of Geriatrics and Gerontology, Division of Brain Sciences, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    J Neurol Sci 285:100-8. 2009
    ..These findings suggest that amyloid PET using [11C]BF-227 is better suited for the prediction of conversion from MCI to AD, while VBM-MRI appears to be better suited for tracking the severity of dementia...
  10. doi request reprint A 18F-labeled BF-227 derivative as a potential radioligand for imaging dense amyloid plaques by positron emission tomography
    Shozo Furumoto
    Department of Pharmacology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, 980 8575, Japan
    Mol Imaging Biol 15:497-506. 2013
    ..e., [18F] fluorinated amyloid imaging compound of Tohoku university ([18F]FACT)) as amyloid positron emission tomography (PET) tracers and to assess [18F]FACT efficacy in imaging of Alzheimer's disease (AD)...
  11. doi request reprint Brain accumulation of amyloid β protein visualized by positron emission tomography and BF-227 in Alzheimer's disease patients with or without diabetes mellitus
    Naoki Tomita
    Department of Geriatrics and Gerontology, Division of Brain Sciences, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Miyagi, Japan
    Geriatr Gerontol Int 13:215-21. 2013
    ..To discover the mechanism of developing dementia in AD patients with DM in a living state, we studied the distribution of amyloid β (Αβ) protein of diabetic AD patients...
  12. doi request reprint Voxel-based analysis of amyloid positron emission tomography probe [C]BF-227 uptake in mild cognitive impairment and alzheimer's disease
    He Shao
    Department of Pharmacology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Dement Geriatr Cogn Disord 30:101-11. 2010
    ....
  13. doi request reprint A traditional medicinal herb Paeonia suffruticosa and its active constituent 1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranose have potent anti-aggregation effects on Alzheimer's amyloid beta proteins in vitro and in vivo
    Hironori Fujiwara
    Center for Asian Traditional Medicine, Tohoku University Graduate School of Medicine, Sendai, Aoba ku, Japan
    J Neurochem 109:1648-57. 2009
    ..PGG is likely to be a safe and promising lead compound in the development of disease-modifying drugs to prevent and/or cure AD...
  14. doi request reprint Novel 18F-labeled arylquinoline derivatives for noninvasive imaging of tau pathology in Alzheimer disease
    Nobuyuki Okamura
    Department of Pharmacology, Tohoku University School of Medicine, Sendai, Japan
    J Nucl Med 54:1420-7. 2013
    ..After compound optimization, we developed novel (18)F-labeled arylquinoline derivatives, (18)F-THK-5105 and (18)F-THK-5117, for use as tau imaging PET tracers...
  15. doi request reprint Synthesis and preliminary evaluation of 2-arylhydroxyquinoline derivatives for tau imaging
    Tetsuro Tago
    Cyclotron and Radioisotope Center CYRIC, Tohoku University, Sendai, 980 8578, Japan
    J Labelled Comp Radiopharm 57:18-24. 2014
    ..15% ID/g at 30 min postinjection) and showed the labeling of NFTs in an AD brain section by autoradiography assay. These findings indicate the availability of [(11) C]THK-951 for in vivo PET imaging of tau pathology in AD...
  16. ncbi request reprint Non-invasive assessment of Alzheimer's disease neurofibrillary pathology using 18F-THK5105 PET
    Nobuyuki Okamura
    1 Department of Pharmacology, Tohoku University School of Medicine, Sendai, Japan
    Brain 137:1762-71. 2014
    ..This technique would be applicable to the longitudinal evaluation of tau deposition and allow a better understanding of the pathophysiology of Alzheimer's disease...
  17. doi request reprint Use of a benzimidazole derivative BF-188 in fluorescence multispectral imaging for selective visualization of tau protein fibrils in the Alzheimer's disease brain
    Ryuichi Harada
    Department of Pharmacology, Tohoku University School of Medicine, 2 1, Seiryo machi, Aoba ku, Sendai, 980 8575, Japan
    Mol Imaging Biol 16:19-27. 2014
    ..Here, we introduce a novel fluorescent probe that can distinguish between these two deposits by multispectral fluorescence imaging technique...
  18. doi request reprint In vivo detection of amyloid plaques in the mouse brain using the near-infrared fluorescence probe THK-265
    Nobuyuki Okamura
    Department of Pharmacology, Tohoku University School of Medicine, Sendai, Japan Innovation of New Biomedical Engineering Center, Tohoku University, Sendai, Japan
    J Alzheimers Dis 23:37-48. 2011
    ..These findings strongly support the usefulness of THK-265 as an NIRF imaging probe for the noninvasive measurement of brain amyloid load...
  19. doi request reprint Analysis of early phase [11C]BF-227 PET, and its application for anatomical standardization of late-phase images for 3D-SSP analysis
    Tomohiro Kaneta
    Department of Diagnostic Radiology, Tohoku University, 1 1 Seiryomachi, Aobaku, Sendai, 980 8574, Japan
    Jpn J Radiol 32:138-44. 2014
    ....
  20. doi request reprint A modified method of 3D-SSP analysis for amyloid PET imaging using [¹¹C]BF-227
    Tomohiro Kaneta
    Department of Diagnostic Radiology, Tohoku University, 1 1 Seiryomachi, Aobaku, Sendai 980 8574, Japan
    Ann Nucl Med 25:732-9. 2011
    ....
  21. doi request reprint Advances in molecular imaging for the diagnosis of dementia
    Nobuyuki Okamura
    Tohoku University, Pharmacology, Sendai, Japan
    Expert Opin Med Diagn 3:705-16. 2009
    ..New targets for molecular imaging are focusing on protein misfolding diseases associated with the neurotoxic deposition of aggregated tau, α-synuclein and prion proteins...
  22. pmc Evaluation of the biodistribution and radiation dosimetry of the 18F-labelled amyloid imaging probe [18F]FACT in humans
    Miho Shidahara
    Division of Medical Physics, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, 980 8575, Japan
    EJNMMI Res 3:32. 2013
    ..The biodistribution and radiation dosimetry of the 18F-labelled amyloid imaging probe ([18F] FACT) was investigated in humans...
  23. ncbi request reprint Styrylbenzoxazole derivatives for in vivo imaging of amyloid plaques in the brain
    Nobuyuki Okamura
    BF Research Institute, Suita 565 0873, Japan
    J Neurosci 24:2535-41. 2004
    ..These findings strongly suggest that styrylbenzoxazole derivatives are promising candidate probes for positron emission tomography and single-photon emission computed tomography imaging for early detection of amyloid plaque formation...
  24. ncbi request reprint Recent advances in the development of amyloid imaging agents
    Shozo Furumoto
    Biomedical Engineering Research Organization, Tohoku University, Sendai 980 8575, Japan
    Curr Top Med Chem 7:1773-89. 2007
    ....
  25. ncbi request reprint Uncaria rhynchophylla, a Chinese medicinal herb, has potent antiaggregation effects on Alzheimer's beta-amyloid proteins
    Hironori Fujiwara
    Department of Geriatric and Complementary Medicine, Center for Asian Traditional Medicine Research, Tohoku University School of Medicine, Sendai, Japan
    J Neurosci Res 84:427-33. 2006
    ....
  26. ncbi request reprint [Development of [18F]FRP-170 injection for imaging hypoxia by PET]
    Yoichi Ishikawa
    Cyclotron and Radioisotope Center, Tohoku University
    Kaku Igaku 42:1-10. 2005
    ..The radiation-absorbed dose to the whole body was estimated to be 1.0 mSv/185 MBq. The [18F]FRP-170 injection proved to be suitable for clinical use without acute toxicity or mutagenicity...
  27. ncbi request reprint Quinoline and benzimidazole derivatives: candidate probes for in vivo imaging of tau pathology in Alzheimer's disease
    Nobuyuki Okamura
    BF Research Institute, Osaka 541 0045, Japan
    J Neurosci 25:10857-62. 2005
    ..Autoradiography using 11C-labeled BF-158 further demonstrated labeling of NFTs in AD brain sections. These findings suggest the potential usefulness of quinoline and benzimidazole derivatives for in vivo imaging of tau pathology in AD...
  28. ncbi request reprint [Alzheimer' s disease]
    Nobuyuki Okamura
    Department of Pharmacology, Tohoku University Graduate School of Medicine
    Nihon Rinsho 65:320-6. 2007
    ....
  29. ncbi request reprint Amyloid imaging probes are useful for detection of prion plaques and treatment of transmissible spongiform encephalopathies
    Kensuke Ishikawa
    Department of Neuropathology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Gen Virol 85:1785-90. 2004
    ..Both BTA-1 and BSB can be expected to be lead chemicals not only for imaging probes but also for therapeutic drugs for TSEs caused by certain strains...