Takuya Kubo

Summary

Affiliation: Tohoku University
Country: Japan

Publications

  1. doi request reprint Effective determination method for a cyanobacterial neurotoxin, beta-N-methylamino-L-alanine
    Takuya Kubo
    Graduate School of Environmental Studies, Tohoku University, Aoba 6 6 20, Aramaki, Aoba ku, Sendai 980 8579, Japan
    Toxicon 51:1264-8. 2008
  2. ncbi request reprint A new simply and effective fractionation method for cylindrospermopsin analyses
    Takuya Kubo
    Graduate School of Environmental Studies, Tohoku University, Aramaki aza aoba 6 6 20, Aoba ku, Sendai 980 8579, Japan
    Toxicon 46:104-7. 2005
  3. doi request reprint Importance of surface properties of affinity resin for capturing a target protein, cyclooxygenase-1
    Tomoko Mori
    Graduate School of Environmental Studies, Tohoku University, Aramaki, Sendai, Japan
    Bioorg Med Chem 17:1587-99. 2009
  4. ncbi request reprint A novel chip device based on wired capillary packed with high performance polymer-based monolith for HPLC: reproducibility in preparation processes to obtain long columns
    Ken Hosoya
    Graduate School of Environmental Studies, Tohoku University, Aoba 6 6 20, Aramaki Aoba, Sendai 980 8579, Japan
    Anal Sci 24:149-54. 2008
  5. ncbi request reprint Simple and effective 3D recognition of domoic acid using a molecularly imprinted polymer
    Koji Nemoto
    Graduate School of Environmental Studies, Tohoku University, Aoba 6 6 20, Aramaki, Aoba ku, Sendai, Japan
    J Am Chem Soc 129:13626-32. 2007
  6. doi request reprint Comprehensive study of proteins that interact with microcystin-LR
    Tomoko Mori
    Graduate School of Environmental Studies, Tohoku University, Aoba 6 6 20, Aramaki, Aoba, Sendai 980 8579, Japan
    Anal Bioanal Chem 402:1137-47. 2012
  7. ncbi request reprint Selective separation of hydroxy polychlorinated biphenyls (HO-PCBs) by the structural recognition on the molecularly imprinted polymers: direct separation of the thyroid hormone active analogues from mixtures
    Takuya Kubo
    Graduate School of Environmental Studies, Tohoku University, Aoba 6 6 20, Aramaki, Aoba ku, Sendai 980 8579, Japan
    Anal Chim Acta 589:180-5. 2007
  8. doi request reprint Novel separation medium spongy monolith for high throughput analyses
    Fuminori Watanabe
    Graduate School of Environmental Studies, Tohoku University, Aoba 6 6 20, Aramaki, Aobaku, Sendai 9808579, Japan
    J Chromatogr A 1216:7402-8. 2009
  9. ncbi request reprint Basic chromatographic properties of polyethylene glycol-type, polymer-based monolithic columns
    Tomoko Mori
    Graduate School of Environmental Studies, Tohoku University, 6 6 20 Aoba, Aramaki, Aoba, Sendai 980 8579, Japan
    Anal Sci 26:311-6. 2010
  10. doi request reprint Synthesis of novel polymer type sulfoxide solid phase combined with the porogen imprinting for enabling selective separation of polychlorinated biphenyls
    Yuichi Tominaga
    Graduate School of Environmental Studies, Tohoku University, Aoba 6 6 20, Aramaki, Aobaku, Sendai 980 8579, Japan
    Chemosphere 89:378-82. 2012

Collaborators

Detail Information

Publications31

  1. doi request reprint Effective determination method for a cyanobacterial neurotoxin, beta-N-methylamino-L-alanine
    Takuya Kubo
    Graduate School of Environmental Studies, Tohoku University, Aoba 6 6 20, Aramaki, Aoba ku, Sendai 980 8579, Japan
    Toxicon 51:1264-8. 2008
    ..The quantitation limit for BMAA based on selected ion monitoring (SIM) was determined as 0.5 ng at a signal/noise ratio of 5...
  2. ncbi request reprint A new simply and effective fractionation method for cylindrospermopsin analyses
    Takuya Kubo
    Graduate School of Environmental Studies, Tohoku University, Aramaki aza aoba 6 6 20, Aoba ku, Sendai 980 8579, Japan
    Toxicon 46:104-7. 2005
    ..The results suggest that the fractionation method is a useful method for CYN analyses and must be utilized for CYN purification...
  3. doi request reprint Importance of surface properties of affinity resin for capturing a target protein, cyclooxygenase-1
    Tomoko Mori
    Graduate School of Environmental Studies, Tohoku University, Aramaki, Sendai, Japan
    Bioorg Med Chem 17:1587-99. 2009
    ....
  4. ncbi request reprint A novel chip device based on wired capillary packed with high performance polymer-based monolith for HPLC: reproducibility in preparation processes to obtain long columns
    Ken Hosoya
    Graduate School of Environmental Studies, Tohoku University, Aoba 6 6 20, Aramaki Aoba, Sendai 980 8579, Japan
    Anal Sci 24:149-54. 2008
    ..Furthermore, the wired chip device column showed that its high performance was kept even after chip preparation...
  5. ncbi request reprint Simple and effective 3D recognition of domoic acid using a molecularly imprinted polymer
    Koji Nemoto
    Graduate School of Environmental Studies, Tohoku University, Aoba 6 6 20, Aramaki, Aoba ku, Sendai, Japan
    J Am Chem Soc 129:13626-32. 2007
    ..Using the 1,3,5-PeTA-MIP, we could easily purify DA from blue mussel extracts by solid-phase extraction...
  6. doi request reprint Comprehensive study of proteins that interact with microcystin-LR
    Tomoko Mori
    Graduate School of Environmental Studies, Tohoku University, Aoba 6 6 20, Aramaki, Aoba, Sendai 980 8579, Japan
    Anal Bioanal Chem 402:1137-47. 2012
    ..Our results demonstrated that our analytical systems based on an original affinity resin and nano-LC/MS/MS were effective for target protein research...
  7. ncbi request reprint Selective separation of hydroxy polychlorinated biphenyls (HO-PCBs) by the structural recognition on the molecularly imprinted polymers: direct separation of the thyroid hormone active analogues from mixtures
    Takuya Kubo
    Graduate School of Environmental Studies, Tohoku University, Aoba 6 6 20, Aramaki, Aoba ku, Sendai 980 8579, Japan
    Anal Chim Acta 589:180-5. 2007
    ..Moreover, these analogues may have a potential for thyroid hormone activities so that we attempted to separate these analogues directly from mixtures of HO-PCBs using a prepared MIP...
  8. doi request reprint Novel separation medium spongy monolith for high throughput analyses
    Fuminori Watanabe
    Graduate School of Environmental Studies, Tohoku University, Aoba 6 6 20, Aramaki, Aobaku, Sendai 9808579, Japan
    J Chromatogr A 1216:7402-8. 2009
    ..The results compared with original spongy monolith demonstrated that a higher adsorption capacity was achieved on a shorter column, and a stable low back pressure was obtained at high throughput elution even with a longer column...
  9. ncbi request reprint Basic chromatographic properties of polyethylene glycol-type, polymer-based monolithic columns
    Tomoko Mori
    Graduate School of Environmental Studies, Tohoku University, 6 6 20 Aoba, Aramaki, Aoba, Sendai 980 8579, Japan
    Anal Sci 26:311-6. 2010
    ....
  10. doi request reprint Synthesis of novel polymer type sulfoxide solid phase combined with the porogen imprinting for enabling selective separation of polychlorinated biphenyls
    Yuichi Tominaga
    Graduate School of Environmental Studies, Tohoku University, Aoba 6 6 20, Aramaki, Aobaku, Sendai 980 8579, Japan
    Chemosphere 89:378-82. 2012
    ....
  11. ncbi request reprint Cylindrospermopsin determination using 2-[4-(2-hydroxyethyl)-1-piperazinyl]ethanesulfonic acid (HEPES) as the internal standard
    Sachiko Kikuchi
    Graduate School of Environmental Studies, Tohoku University, 6 6 20, Aoba, Aramaki, Aoba ku, Sendai 980 8579, Japan
    Anal Chim Acta 583:124-7. 2007
    ..CYN in waters should be condensed for determination. This method including the treatment for isolation and condensation of CYN is useful for determination of CYN in environmental and/or drinking waters...
  12. doi request reprint Polymers of 2-methacryloyloxyethyl phosphorylcholine truly work as cell membrane mimic?
    Tomoko Mori
    Graduate School of Environmental Studies, Tohoku University, Aoba, Sendai, Japan
    Colloids Surf B Biointerfaces 84:181-6. 2011
    ..These results suggested that the position of PC groups realized hydrophilic polymer surface, while MPC based polymer was not able to supply the suitable environment for COX-1 to interact with Ibu...
  13. doi request reprint Determination of bisphenol A with effective pretreatment medium using automated column-switching HPLC with fluorescence detection
    Tetsuya Tanigawa
    Graduate School of Environmental Studies, Tohoku University, Sendai, Japan
    J Sep Sci 34:2840-6. 2011
    ..Limit of detection (LOD) in real sample was <0.7 ng/L. Repeatability was around 1.4% and recovery was around 97% or more. A particular pressure increase was not observed in 150 repeated analyses of real river water samples...
  14. ncbi request reprint A novel biosurfactant, 2-acyloxyethylphosphonate, isolated from waterblooms of Aphanizomenon flos-aquae
    Kunimitsu Kaya
    Graduate School of Environmental Studies, Tohoku University, Aoba ku, Sendai 980 8579, Japan
    Molecules 11:539-48. 2006
    ..Considering the isolated surfactant molecule as hexadecanoyloxyethylphosphonic acid (mw. 364), the critical micelle concentration (CMC) was about 22 mM...
  15. ncbi request reprint Properties of flaky affinity resin with co-continuous structure
    Tomoko Mori
    Graduate School of Environmental Studies, Tohoku University, Aoba 6 6 20, Aramaki, Aoba ku, Sendai 980 8579, Japan
    Bioorg Med Chem 16:1983-91. 2008
    ..The observed properties of the flaky affinity resin as well as ease in handling are really useful for capture of the target proteins of possible rare ligands...
  16. ncbi request reprint Solvent effects in the preparation of molecularly imprinted polymers for melatonin using N-propionyl-5-methoxytryptamine as the pseudo template
    Makoto Nomachi
    Graduate School of Environmental Studies, Tohoku University, 6 6 20 Aoba, Aramaki, Aoba ku, Sendai, 980 8579, Japan
    Anal Bioanal Chem 384:1291-6. 2006
    ..Hydrogen bonding between the template, the functional monomer, and solvent can be estimated from the chemical shifts in 1H NMR spectra of those molecules in the solvent...
  17. ncbi request reprint Fully automated liquid chromatography-mass spectrometry determination of 17beta-estradiol in river water
    Yoshiyuki Watabe
    Analytical Applications Department, Shimadzu Corporation, Nishinokyo, Kyoto 604 8500, Japan
    J Chromatogr A 1120:252-9. 2006
    ....
  18. ncbi request reprint Target-selective ion-exchange media for highly hydrophilic compounds: a possible solution by use of the "interval immobilization technique"
    Takuya Kubo
    Department of Polymer Science and Engineering, Kyoto Institute of Technology, Matsugasaki, Sakyo ku, Kyoto 606 8585, Japan
    Anal Bioanal Chem 378:84-8. 2004
    ..Results from detailed HPLC evaluation and measurement of the difference between the binding affinity for CYN and for other compounds showed the prepared polymer had specific recognition ability for CYN...
  19. doi request reprint New values of molecular extinction coefficient and specific rotation for cyanobacterial toxin cylindrospermopsin
    Tomoharu Sano
    National Institute for Environmental Studies, Onogawa 16 2, Tsukuba, Ibaraki 305 8506, Japan
    Toxicon 51:717-9. 2008
    ..In order to determine CYN concentrations in solutions using UV absorption, the epsilon-value of CYN should be corrected from 5800 to 9800. Further, the [alpha](D) value of CYN should be corrected from +12.5 degrees to +17.0 degrees ...
  20. ncbi request reprint Recognition of hepatotoxic homologues of Microcystin using a combination of selective adsorption media
    Takuya Kubo
    Department of Polymer Science, Kyoto Institute of Technology, Matsugasaki, Sakyo ku, Kyoto 606 8585, Japan
    J Sep Sci 27:316-24. 2004
    ..We have demonstrated the first group recognition for Microcystin homologues through combination of two different selective adsorption media prepared by a fragment imprinting technique...
  21. ncbi request reprint Preparation of glycerol dimethacrylate-based polymer monolith with unusual porous properties achieved via viscoelastic phase separation induced by monodisperse ultra high molecular weight poly(styrene) as a porogen
    Hiroshi Aoki
    Department of Polymer Science and Engineering, Kyoto Institute of Technology, Matsugasaki, Sakyo ku, Kyoto, Japan
    J Chromatogr A 1119:66-79. 2006
    ....
  22. ncbi request reprint Novel surface modification of polymer-based separation media controlling separation selectivity, retentivity and generation of electroosmotic flow
    Ken Hosoya
    Department of Polymer Science, Kyoto Institute of Technology, Matsugasaki, Sakyo ku, Kyoto 606 8585, Japan
    J Chromatogr A 979:3-10. 2002
    ....
  23. ncbi request reprint On-column concentration of bisphenol A with one-step removal of humic acids in water
    Takuya Kubo
    Department of Polymer Science, Kyoto Institute of Technology, Matsugasaki, Sakyo ku, Kyoto 606 8585, Japan
    J Chromatogr A 987:389-94. 2003
    ....
  24. ncbi request reprint Novel surface-modification techniques for polymer-based separation media. Stimulus-responsive phenomena based on double polymeric selectors
    Ken Hosoya
    Department of Polymer Science, Kyoto Institute of Technology, Matsugasaki, Sakyo ku, Kyoto 606 8585, Japan
    J Chromatogr A 1030:237-46. 2004
    ..Moreover, pH responsive ability was studied by using buffer of either pH 4 or 10 as mobile phase. Slope of the plot was changed in buffer of pH 4, but no change of slope was observed in the buffer of pH 10...
  25. ncbi request reprint Interval immobilization technique for recognition toward a highly hydrophilic cyanobacterium toxin
    Takuya Kubo
    Department of Polymer Science and Engineering, Kyoto Institute of Technology, Matsugasaki, Sakyo ku, Kyoto 606 8585, Japan
    J Chromatogr B Analyt Technol Biomed Life Sci 806:229-35. 2004
    ..Further studies proved that the association constant for CYN on this medium was slightly higher than that on blank polymer...
  26. ncbi request reprint Chromatographic molecular recognition for catechol-related compounds using thiacalix[4]arene as an effective selector
    Ken Hosoya
    Department of Polymer Science and Engineering, Kyoto Institute of Technology, Matsugasaki, Sakyo ku, Kyoto, 606 8585 Japan
    Anal Bioanal Chem 380:343-5. 2004
    ..Specific chromatographic retention behavior was observed for catechol relative to positional isomers of xylene, cresol, and benzene-diol. Catecholamine and catechol showed specific chromatographic retention behavior...
  27. ncbi request reprint A molecular recognition strategy towards tetra-chlorinated dibenzo-p-dioxins, TCDDs
    Ken Hosoya
    Department of Polymer Science, Kyoto Institute of Technology, Matsugasaki, Sakyo ku, Kyoto 606 8585, Japan
    Biosens Bioelectron 20:1185-9. 2004
    ..It was also found that positional relationship between substituted chlorine atoms was also important for chromatographic recognition...
  28. ncbi request reprint LC/MS determination of bisphenol A in river water using a surface-modified molecularly-imprinted polymer as an on-line pretreatment device
    Yoshiyuki Watabe
    Department of Polymer Science and Engineering, Kyoto Institute of Technology, Matsugasaki, Sakyo ku, 606 8585, Japan
    Anal Bioanal Chem 381:1193-8. 2005
    ..This method was successfully applied to the trace determination of BPA in environmental water samples using LC/MS...
  29. ncbi request reprint Silica monolithic membrane as separation medium. Summable property of different membranes for high-performance liquid chromatographic separation
    Ken Hosoya
    Department of Polymer Science and Engineering, Kyoto Institute of Technology, Matsugasaki, Sakyo ku, Kyoto 606 8585, Japan
    J Chromatogr A 1073:123-6. 2005
    ..We confirmed that the membrane column was able to separate HbA1c from other matrix in whole blood to some extent, and it also had an excellent ability for hydrophobic and ion exchange adsorption...
  30. ncbi request reprint Novel surface modified molecularly imprinted polymer focused on the removal of interference in environmental water samples for chromatographic determination
    Yoshiyuki Watabe
    Department of Polymer Science and Engineering, Kyoto Institute of Technology, Matsugasaki, Sakyo ku, Kyoto 606 8585, Japan
    J Chromatogr A 1073:363-70. 2005
    ..36 ppt when electrochemical detection was used. Actual samples, including Suwannee River natural organic matter (NOM), were applied and BPA was detected in the NOM even if widely used UV detection was employed...
  31. ncbi request reprint Spiroidesin, a novel lipopeptide from the cyanobacterium Anabaena spiroides that inhibits cell growth of the cyanobacterium Microcystis aeruginosa
    Kunimitsu Kaya
    Laboratory of Intellectual Fundamentals for Environmental Studies, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
    J Nat Prod 65:920-1. 2002
    ..The structure was identified by 2D NMR and chemical degradation analyses. Spiroidesin inhibited cell growth of the toxic cyanobacterium Microcystis aeruginosa (IC(50), 1.6 x 10(-6) M)...