Hiroshi Kubo

Summary

Affiliation: Tohoku University
Country: Japan

Publications

  1. pmc Isolation of alveolar epithelial type II progenitor cells from adult human lungs
    Naoya Fujino
    Department of Advanced Preventive Medicine for Infectious Disease, Tohoku University Graduate School of Medicine, Aobaku, Sendai, Japan
    Lab Invest 91:363-78. 2011
  2. ncbi request reprint c-Kit immunoexpression delineates a putative endothelial progenitor cell population in developing human lungs
    Takaya Suzuki
    Dept of Advanced Preventive Medicine for Infectious Disease, Tohoku Univ School of Medicine, 2 1 Seiryoumachi, Aobaku, Sendai 980 8575, Japan
    Am J Physiol Lung Cell Mol Physiol 306:L855-65. 2014
  3. pmc The increase of microRNA-21 during lung fibrosis and its contribution to epithelial-mesenchymal transition in pulmonary epithelial cells
    Mitsuhiro Yamada
    Department of Advanced Preventive Medicine for Infectious Disease, Tohoku University Graduate School of Medicine, 2 1 Seiryoumachi, Aobaku 980 8575, Sendai, Japan
    Respir Res 14:95. 2013
  4. pmc Concise review: clinical prospects for treating chronic obstructive pulmonary disease with regenerative approaches
    Hiroshi Kubo
    Department of Advanced Preventive Medicine for Infectious Disease, Tohoku University Graduate School of Medicine, Sendai, Japan
    Stem Cells Transl Med 1:627-31. 2012
  5. doi request reprint Tissue engineering for pulmonary diseases: insights from the laboratory
    Hiroshi Kubo
    Department of Advanced Preventive Medicine for Infectious Disease, Tohoku University Graduate School of Medicine, Sendai, Japan
    Respirology 17:445-54. 2012
  6. doi request reprint Molecular basis of lung tissue regeneration
    Hiroshi Kubo
    Department of Advanced Preventive Medicine for Infectious Disease, Tohoku University Graduate School of Medicine, 2 1 Seiryoumachi, Aobaku, Sendai 980 8575, Japan
    Gen Thorac Cardiovasc Surg 59:231-44. 2011
  7. ncbi request reprint Inhibitory effects of carbocisteine on type A seasonal influenza virus infection in human airway epithelial cells
    Mutsuo Yamaya
    Dept of Advanced Preventive Medicine for Infectious Disease, Tohoku Univ School of Medicine, Seiryo machi, Aoba ku, Sendai, Japan
    Am J Physiol Lung Cell Mol Physiol 299:L160-8. 2010
  8. ncbi request reprint The role of the receptor for advanced glycation end-products in lung fibrosis
    Mei He
    Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, Sendai, Japan
    Am J Physiol Lung Cell Mol Physiol 293:L1427-36. 2007
  9. doi request reprint Intranasal HGF administration ameliorates the physiologic and morphologic changes in lung emphysema
    Ahmed E Hegab
    Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, Aobaku, Sendai, Japan
    Mol Ther 16:1417-26. 2008
  10. doi request reprint A novel method for isolating individual cellular components from the adult human distal lung
    Naoya Fujino
    Department of Advanced Preventive Medicine for Infectious Disease, Tohoku University Graduate School of Medicine, Aobaku, Sendai, Japan
    Am J Respir Cell Mol Biol 46:422-30. 2012

Collaborators

Detail Information

Publications49

  1. pmc Isolation of alveolar epithelial type II progenitor cells from adult human lungs
    Naoya Fujino
    Department of Advanced Preventive Medicine for Infectious Disease, Tohoku University Graduate School of Medicine, Aobaku, Sendai, Japan
    Lab Invest 91:363-78. 2011
    ..Our findings demonstrated that adult human lungs contain a progenitor population for ATII cells. This study is a first step toward better understanding of stem cell biology in adult human lung alveoli...
  2. ncbi request reprint c-Kit immunoexpression delineates a putative endothelial progenitor cell population in developing human lungs
    Takaya Suzuki
    Dept of Advanced Preventive Medicine for Infectious Disease, Tohoku Univ School of Medicine, 2 1 Seiryoumachi, Aobaku, Sendai 980 8575, Japan
    Am J Physiol Lung Cell Mol Physiol 306:L855-65. 2014
    ..Our results suggest that c-Kit expression in early fetal lungs marks a progenitor population that is restricted to endothelial lineage. This study also suggests the potential involvement of c-Kit signaling in lung vascular development. ..
  3. pmc The increase of microRNA-21 during lung fibrosis and its contribution to epithelial-mesenchymal transition in pulmonary epithelial cells
    Mitsuhiro Yamada
    Department of Advanced Preventive Medicine for Infectious Disease, Tohoku University Graduate School of Medicine, 2 1 Seiryoumachi, Aobaku 980 8575, Sendai, Japan
    Respir Res 14:95. 2013
    ..However, expression changes in microRNA-21 and the role of microRNA-21 in epithelial-mesenchymal transition during lung fibrosis have not yet been defined...
  4. pmc Concise review: clinical prospects for treating chronic obstructive pulmonary disease with regenerative approaches
    Hiroshi Kubo
    Department of Advanced Preventive Medicine for Infectious Disease, Tohoku University Graduate School of Medicine, Sendai, Japan
    Stem Cells Transl Med 1:627-31. 2012
    ....
  5. doi request reprint Tissue engineering for pulmonary diseases: insights from the laboratory
    Hiroshi Kubo
    Department of Advanced Preventive Medicine for Infectious Disease, Tohoku University Graduate School of Medicine, Sendai, Japan
    Respirology 17:445-54. 2012
    ..These results give us a greater understanding of the possibilities and the limitations of tissue engineering for pulmonary diseases...
  6. doi request reprint Molecular basis of lung tissue regeneration
    Hiroshi Kubo
    Department of Advanced Preventive Medicine for Infectious Disease, Tohoku University Graduate School of Medicine, 2 1 Seiryoumachi, Aobaku, Sendai 980 8575, Japan
    Gen Thorac Cardiovasc Surg 59:231-44. 2011
    ....
  7. ncbi request reprint Inhibitory effects of carbocisteine on type A seasonal influenza virus infection in human airway epithelial cells
    Mutsuo Yamaya
    Dept of Advanced Preventive Medicine for Infectious Disease, Tohoku Univ School of Medicine, Seiryo machi, Aoba ku, Sendai, Japan
    Am J Physiol Lung Cell Mol Physiol 299:L160-8. 2010
    ..l-carbocisteine may reduce airway inflammation in influenza virus infection...
  8. ncbi request reprint The role of the receptor for advanced glycation end-products in lung fibrosis
    Mei He
    Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, Sendai, Japan
    Am J Physiol Lung Cell Mol Physiol 293:L1427-36. 2007
    ..Our results suggested that RAGE contributes to bleomycin-induced lung fibrosis through EMT and profibrotic cytokine production. Thus, RAGE may be a new therapeutic target for pulmonary fibrosis...
  9. doi request reprint Intranasal HGF administration ameliorates the physiologic and morphologic changes in lung emphysema
    Ahmed E Hegab
    Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, Aobaku, Sendai, Japan
    Mol Ther 16:1417-26. 2008
    ....
  10. doi request reprint A novel method for isolating individual cellular components from the adult human distal lung
    Naoya Fujino
    Department of Advanced Preventive Medicine for Infectious Disease, Tohoku University Graduate School of Medicine, Aobaku, Sendai, Japan
    Am J Respir Cell Mol Biol 46:422-30. 2012
    ....
  11. ncbi request reprint Hepatocyte growth factor induces angiogenesis in injured lungs through mobilizing endothelial progenitor cells
    Kota Ishizawa
    Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, Sendai, Miyagi 980 8574, Japan
    Biochem Biophys Res Commun 324:276-80. 2004
    ..These complex effects induced by HGF orchestrate pulmonary regeneration in emphysematous lung parenchyma...
  12. doi request reprint Isolation and characterization of murine multipotent lung stem cells
    Ahmed E Hegab
    Department of Advanced Preventive Medicine for Infectious Disease, Tohoku University School of Medicine, Sendai, Japan
    Stem Cells Dev 19:523-36. 2010
    ..These cells may provide useful tools for the study of lung stem cells and the assessment of new therapeutic approaches for lung diseases...
  13. doi request reprint l-carbocisteine inhibits respiratory syncytial virus infection in human tracheal epithelial cells
    Masanori Asada
    Department of Infectious Disease, Sendai City Hospital, Sendai, Japan
    Respir Physiol Neurobiol 180:112-8. 2012
    ..These findings suggest that l-carbocisteine may inhibit RS virus infection by reducing the expression of ICAM-1. It may also modulate airway inflammation during RS virus infection...
  14. doi request reprint Differences in the released endothelial microparticle subtypes between human pulmonary microvascular endothelial cells and aortic endothelial cells in vitro
    Toru Takahashi
    Department of Advanced Preventive Medicine for Infectious Disease, Tohoku University Graduate School of Medicine, Sendai, Japan
    Exp Lung Res 39:155-61. 2013
    ..The differences in circulating EMP subtypes may reflect a condition or site of endothelial injury and may serve as markers for endothelial damage in COPD patients...
  15. ncbi request reprint Bone marrow-derived progenitor cells are important for lung repair after lipopolysaccharide-induced lung injury
    Mitsuhiro Yamada
    Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, 1 1 Seiryou Machi, Aobaku, Sendai 980 8574, Japan
    J Immunol 172:1266-72. 2004
    ..Reconstitution of the bone marrow prevents these changes. These data suggest that BMPCs are important and required for lung repair after LPS-induced lung injury...
  16. doi request reprint Clarithromycin inhibits type a seasonal influenza virus infection in human airway epithelial cells
    Mutsuo Yamaya
    Department of Advanced Preventive Medicine for Infectious Disease, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku 980 8575, Japan
    J Pharmacol Exp Ther 333:81-90. 2010
    ..Clarithromycin may modulate airway inflammation in influenza virus infection...
  17. pmc Levofloxacin inhibits rhinovirus infection in primary cultures of human tracheal epithelial cells
    Mutsuo Yamaya
    Department of Advanced Preventive Medicine for Infectious Disease, Tohoku University Graduate School of Medicine, Sendai, Japan
    Antimicrob Agents Chemother 56:4052-61. 2012
    ..These results suggest that LVFX inhibits major-group rhinovirus infections in part by reducing ICAM-1 expression levels and the number of acidic endosomes. LVFX may also modulate airway inflammation in rhinoviral infections...
  18. doi request reprint Administration of a specific inhibitor of neutrophil elastase attenuates pulmonary fibrosis after acute lung injury in mice
    Naoya Fujino
    Department of Advanced Preventive Medicine for Infectious Disease, Tohoku University Graduate School of Medicine, Sendai, Japan
    Exp Lung Res 38:28-36. 2012
    ..In addition, these data suggest that this neutrophil elastase inhibitor has therapeutic potential for the fibroproliferative phase of ALI/ARDS...
  19. doi request reprint Procaterol inhibits rhinovirus infection in primary cultures of human tracheal epithelial cells
    Mutsuo Yamaya
    Department of Advanced Preventive Medicine for Infectious Disease, Tohoku University Graduate School of Medicine, Japan
    Eur J Pharmacol 650:431-44. 2011
    ..ICI 118551 also reversed the effects of procaterol on cAMP levels. Procaterol may inhibit rhinovirus infection by reducing ICAM-1 and acidic endosomes as well as modulate airway inflammation in rhinovirus infection...
  20. ncbi request reprint Endogenous secretory receptor for advanced glycation end products in non-small cell lung carcinoma
    Seiichi Kobayashi
    Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, 1 1 Seiryoumachi, Aobaku, Sendai, Japan
    Am J Respir Crit Care Med 175:184-9. 2007
    ..A recently discovered novel splice variant, the endogenous secretory receptor for advanced glycation end products, mediates the receptor for advanced glycation end-product-associated cell responses by functioning as a decoy receptor...
  21. doi request reprint Analysis of gene expression profiles in alveolar epithelial type II-like cells differentiated from human alveolar epithelial progenitor cells
    Naoya Fujino
    Department of Advanced Preventive Medicine for Infectious Disease, Tohoku University Graduate School of Medicine, 2 1 Seiryoumachi, Aobaku, Sendai 980 8575, Japan
    Respir Investig 50:110-6. 2012
    ..However, global gene expression patterns in the ATII-like cells derived from the progenitor cells and in mature ATII cells isolated from lung tissue have not yet been evaluated...
  22. doi request reprint Inhibitory effects of tiotropium on rhinovirus infection in human airway epithelial cells
    Mutsuo Yamaya
    Dept of Advanced Preventive Medicine for Infectious Disease, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, 980 8575, Japan
    Eur Respir J 40:122-32. 2012
    ..Tiotropium may inhibit RV14 infection by reducing the levels of ICAM-1 and acidic endosomes and may also modulate airway inflammation in rhinovirus infection...
  23. ncbi request reprint Bone marrow-derived cells contribute to lung regeneration after elastase-induced pulmonary emphysema
    Kota Ishizawa
    Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, Sendai, 980 8574, Miyagi, Japan
    FEBS Lett 556:249-52. 2004
    ..ATRA or G-CSF promoted lung regeneration and increased bone marrow-derived cell (BMC) numbers in alveoli. Combined treatment of both had an additive effect, which indicated that BMC mobilization might be important in lung regeneration...
  24. doi request reprint Increased circulating endothelial microparticles in COPD patients: a potential biomarker for COPD exacerbation susceptibility
    Toru Takahashi
    Department of Advanced Preventive Medicine for Infectious Disease, Tohoku University Graduate School of Medicine, 2 1 Seiryoumachi, Aobaku, Sendai 980 8575, Japan
    Thorax 67:1067-74. 2012
    ..The influence of COPD exacerbation on the endothelium is not completely understood. Circulating endothelial microparticles (EMPs) are membrane vesicles in circulating blood that are shed by activated or apoptotic endothelial cells...
  25. doi request reprint The increase in surface CXCR4 expression on lung extravascular neutrophils and its effects on neutrophils during endotoxin-induced lung injury
    Mitsuhiro Yamada
    Department of Regional Cooperation for Infectious Diseases, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
    Cell Mol Immunol 8:305-14. 2011
    ..The CXCL12/CXCR4 signaling pathway plays an important role in the modulation of neutrophil activity during acute lung injury, not only by promoting chemotaxis but also by suppressing cell death...
  26. ncbi request reprint Macrolide antibiotics inhibit respiratory syncytial virus infection in human airway epithelial cells
    Masanori Asada
    Department of Geriatrics and Gerontology, Tohoku University School of Medicine, Sendai, Japan
    Antiviral Res 83:191-200. 2009
    ....
  27. ncbi request reprint Interferon-gamma: a key contributor to hyperoxia-induced lung injury in mice
    Mitsuhiro Yamada
    Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, Sendai, Miyagi, Japan
    Am J Physiol Lung Cell Mol Physiol 287:L1042-7. 2004
    ..Therefore, these data strongly suggest that IFN-gamma is a key molecular contributor to hyperoxia-induced lung injury...
  28. pmc Receptor for advanced glycation end products binds to phosphatidylserine and assists in the clearance of apoptotic cells
    Mei He
    Department of Advanced Preventive Medicine for Infectious Disease, Tohoku University Graduate School of Medicine, Sendai 980 8575, Japan
    EMBO Rep 12:358-64. 2011
    ..Our results indicate that RAGE functions as a phosphatidylserine receptor and assists in the clearance of apoptotic cells...
  29. doi request reprint Impaired endothelial progenitor cell mobilization and colony-forming capacity in chronic obstructive pulmonary disease
    Toru Takahashi
    Department of Anesthesiology, Tohoku University Hospital Department of Advanced Preventive Medicine for Infectious Disease, Tohoku University Graduate School of Medicine, Sendai Division of Thoracic Surgery, Japanese Red Cross Ishinomaki Hospital, Ishinomaki, Japan
    Respirology 16:680-7. 2011
    ..We evaluated whether the mobilization and proliferation of EPC are impaired in COPD patients...
  30. ncbi request reprint Effects of carbenoxolone on alveolar fluid clearance and lung inflammation in the rat
    Satoshi Suzuki
    Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, 4 1 Seiryo machi, Aoba ku, Sendai, Japan
    Crit Care Med 32:1910-5. 2004
    ..Since 11beta-HSD2 has been detected in lung epithelial cells, we examined whether carbenoxolone, a potent inhibitor of 11beta-HSD, would enhance endogenous glucocorticoid action on lung fluid balance and inflammation...
  31. doi request reprint Erythromycin attenuates MUC5AC synthesis and secretion in cultured human tracheal cells infected with RV14
    Daisuke Inoue
    Department of Geriatrics and Gerontology, Tohoku University Hospital, Sendai, Japan
    Respirology 13:215-20. 2008
    ..The aim of this study was to examine the effect of erythromycin on RV14-induced airway mucin overproduction and hypersecretion...
  32. ncbi request reprint Single dexamethasone injection increases alveolar fluid clearance in adult rats
    Masafumi Noda
    Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, 4 1 Seiryo machi, Aoba ku, Sendai, Japan
    Crit Care Med 31:1183-9. 2003
    ..We examined whether single dexamethasone injection at therapeutic doses would modulate lung epithelial Na+ channels and Na+/K+-ATPase and increase alveolar fluid clearance in adult rats...
  33. ncbi request reprint Inflammatory and bronchospastic factors in asthma exacerbations caused by upper respiratory tract infections
    Hiroyasu Yasuda
    Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, Tohoku University School of Medicine, 1 1 Seiryomachi, Aoba ku, Sendai, Japan
    Tohoku J Exp Med 207:109-18. 2005
    ..These findings suggest that respiratory viral infections may cause acute asthma exacerbations via the production of mediators that induce inflammation and bronchospasm...
  34. ncbi request reprint Effects of rewarming on nuclear factor-kappaB and interleukin 8 expression in cold-preserved alveolar epithelial cells
    Kunihiko Inoue
    Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    Transplantation 76:409-15. 2003
    ....
  35. doi request reprint Inducible disruption of autophagy in the lung causes airway hyper-responsiveness
    Daisuke Inoue
    Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Aoba ku, Sendai, Japan
    Biochem Biophys Res Commun 405:13-8. 2011
    ..This study demonstrates the critical role of autophagy in the lungs for the maintenance of pulmonary homeostasis...
  36. doi request reprint Carbocisteine inhibits oxidant-induced apoptosis in cultured human airway epithelial cells
    Motoki Yoshida
    Department of Geriatrics, Tohoku University School of Medicine, Sendai, Japan
    Respirology 14:1027-34. 2009
    ..The mechanisms underlying the inhibitory effects of L-carbocisteine on oxidant-induced COPD exacerbations were examined in an in vitro study of human airway epithelial cells...
  37. ncbi request reprint Ambroxol inhibits rhinovirus infection in primary cultures of human tracheal epithelial cells
    Mutsuo Yamaya
    Department of Advanced Preventive Medicine for Infectious Disease, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, 980 8575, Japan
    Arch Pharm Res 37:520-9. 2014
    ..Ambroxol may modulate airway inflammation by reducing the production of cytokines in rhinovirus infection...
  38. ncbi request reprint Early changes in alveolar fluid clearance by nitric oxide after endotoxin instillation in rats
    Hiroyoshi Tsubochi
    Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    Am J Respir Crit Care Med 167:205-10. 2003
    ..NO is produced via inducible NO synthase in endotoxin-stimulated alveolar macrophages and was also shown to increase alveolar fluid clearance at 24 hours...
  39. ncbi request reprint Dexamethasone upregulates 11beta-hydroxysteroid dehydrogenase type 2 in BEAS-2B cells
    Satoshi Suzuki
    Department of Thoracic Surgery, Institute of Development, Aging, and Cancer, Tohoku University, 4 1 Seiryo machi, Aoba ku, Sendai, Japan 980 8575
    Am J Respir Crit Care Med 167:1244-9. 2003
    ....
  40. ncbi request reprint Formoterol and budesonide inhibit rhinovirus infection and cytokine production in primary cultures of human tracheal epithelial cells
    Mutsuo Yamaya
    Department of Advanced Preventive Medicine for Infectious Disease, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan Electronic address
    Respir Investig 52:251-60. 2014
    ..However, inhibitory effects of LABAs and ICSs on the replication of rhinovirus (RV), the major cause of exacerbations, have not been demonstrated...
  41. doi request reprint Accumulation of p62/SQSTM1 is associated with poor prognosis in patients with lung adenocarcinoma
    Daisuke Inoue
    Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan
    Cancer Sci 103:760-6. 2012
    ..The prognostic impact of p62 status was pronounced in adenocarcinoma patients, suggesting that molecular mechanisms underlying cancer evolution differ between adenocarcinoma and squamous cell carcinoma...
  42. ncbi request reprint Randomized phase II trial comparing nitroglycerin plus vinorelbine and cisplatin with vinorelbine and cisplatin alone in previously untreated stage IIIB/IV non-small-cell lung cancer
    Hiroyasu Yasuda
    Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, Seiryo machi, Aoba ku, Sendai, Japan
    J Clin Oncol 24:688-94. 2006
    ..To investigate the efficacy and safety of nitroglycerin plus vinorelbine and cisplatin in patients with previously untreated stage IIIB/IV non-small-cell lung cancer (NSCLC) as the experimental arm for the next phase III trial...
  43. doi request reprint Total synthesis and biological assessment of (-)-exiguolide and analogues
    Haruhiko Fuwa
    Graduate School of Life Sciences, Tohoku University, Aoba ku, Sendai, Japan
    Chemistry 17:2678-88. 2011
    ..Moreover, we have investigated structure-activity relationships of (-)-exiguolide, which elucidated that the C5-methoxycarbonylmethylidene group and the length of the side chain are important for the potent activity...
  44. ncbi request reprint [Regenerative approach for COPD]
    Hiroshi Kubo
    Department of Advanced Preventive Medicine for Infectious Disease, Tohoku University Graduate School of Medicine
    Nihon Rinsho 69:1869-72. 2011
    ..Although lungs are the most challenging organ for regenerative medicine, our cumulative knowledge of lung regeneration and of endogenous progenitor cells makes clear the possibilities for regenerative approach to COPD...
  45. ncbi request reprint The role of microparticles in chronic obstructive pulmonary disease
    Toru Takahashi
    Department of Advanced Preventive Medicine for Infectious Disease, Tohoku University Graduate School of Medicine, Sendai, Japan Cellular and molecular lung biology research units, Institut de recherches cliniques de Montreal IRCM, Montreal, Quebec, Canada Department of Anesthesiology, Tohoku University Hospital, Sendai, Japan
    Int J Chron Obstruct Pulmon Dis 9:303-14. 2014
    ..In addition, circulating MPs are proposed to have several physiological functions in vivo, such as intercellular crosstalk; the increase in EMPs in COPD seems to play a role in the pathophysiology of this disease. ..
  46. doi request reprint Removal of arsenic in coal fly ash by acid washing process using dilute H2SO4 solvent
    Shunsuke Kashiwakura
    Graduate School of Environmental Studies, Tohoku University, Aoba ku, Sendai, Japan
    J Hazard Mater 181:419-25. 2010
    ....
  47. ncbi request reprint Hypoxia diminishes toll-like receptor 4 expression through reactive oxygen species generated by mitochondria in endothelial cells
    Itaru Ishida
    Department of Thoracic Surgery, Tohoku University, Sendai, Japan
    J Immunol 169:2069-75. 2002
    ..We conclude that hypoxia decreases TLR4 expression in endothelial cells and that this change is mediated by mitochondrial ROS leading to attenuation of AP-1 transcriptional activity...