Kiyoshi Ito

Summary

Affiliation: Tohoku University
Country: Japan

Publications

  1. ncbi request reprint 14-3-3sigma in endometrial cancer--a possible prognostic marker in early-stage cancer
    Kiyoshi Ito
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Clin Cancer Res 11:7384-91. 2005
  2. doi request reprint Inhibition of estrogen actions in human gynecological malignancies: new aspects of endocrine therapy for endometrial cancer and ovarian cancer
    Kiyoshi Ito
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Aoba ku, Sendai, Japan
    Mol Cell Endocrinol 340:161-7. 2011
  3. ncbi request reprint Hormone replacement therapy and cancers: the biological roles of estrogen and progestin in tumorigenesis are different between the endometrium and breast
    Kiyoshi Ito
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Tohoku J Exp Med 212:1-12. 2007
  4. ncbi request reprint Orphan nuclear receptor DAX-1 in human endometrium and its disorders
    Sumika Saito
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendia 980 8575, Japan
    Cancer Sci 96:645-52. 2005
  5. doi request reprint Local biosynthesis of estrogen in human endometrial carcinoma through tumor-stromal cell interactions
    Naomi Takahashi-Shiga
    Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Sendai, Japan
    Clin Cancer Res 15:6028-34. 2009
  6. doi request reprint MicroRNA-34b functions as a potential tumor suppressor in endometrial serous adenocarcinoma
    Eri Hiroki
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Int J Cancer 131:E395-404. 2012
  7. ncbi request reprint Progesterone receptor isoforms as a prognostic marker in human endometrial carcinoma
    Sumika Saito
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai 980 8574, Japan
    Cancer Sci 97:1308-14. 2006
  8. doi request reprint Expression of retinoic acid receptors in human endometrial carcinoma
    Kojiro Tanabe
    Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Sendai, Japan
    Cancer Sci 99:267-71. 2008
  9. ncbi request reprint Expression of estrogen-responsive finger protein (Efp) is associated with advanced disease in human epithelial ovarian cancer
    Michiko Sakuma
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    Gynecol Oncol 99:664-70. 2005
  10. ncbi request reprint Prognoses and prognostic factors of carcinosarcoma, endometrial stromal sarcoma and uterine leiomyosarcoma: a comparison with uterine endometrial adenocarcinoma
    Jun ichi Akahira
    Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Oncology 71:333-40. 2006

Detail Information

Publications85

  1. ncbi request reprint 14-3-3sigma in endometrial cancer--a possible prognostic marker in early-stage cancer
    Kiyoshi Ito
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Clin Cancer Res 11:7384-91. 2005
    ..We examined expression of 14-3-3sigma, a regulator of cell proliferation, and evaluated its clinical significance in endometrioid endometrial carcinoma...
  2. doi request reprint Inhibition of estrogen actions in human gynecological malignancies: new aspects of endocrine therapy for endometrial cancer and ovarian cancer
    Kiyoshi Ito
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Aoba ku, Sendai, Japan
    Mol Cell Endocrinol 340:161-7. 2011
    ..However, at least at this juncture, further studies should be required to establish an aromatase inhibitor treatment as one form of endocrine therapy of ovarian carcinoma in future...
  3. ncbi request reprint Hormone replacement therapy and cancers: the biological roles of estrogen and progestin in tumorigenesis are different between the endometrium and breast
    Kiyoshi Ito
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Tohoku J Exp Med 212:1-12. 2007
    ..In addition, the biological significance of progesterone receptor isoforms differs between endometrial and breast carcinomas. These findings may provide new insights into the biology of "estrogen-dependent tissues"...
  4. ncbi request reprint Orphan nuclear receptor DAX-1 in human endometrium and its disorders
    Sumika Saito
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendia 980 8575, Japan
    Cancer Sci 96:645-52. 2005
    ....
  5. doi request reprint Local biosynthesis of estrogen in human endometrial carcinoma through tumor-stromal cell interactions
    Naomi Takahashi-Shiga
    Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Sendai, Japan
    Clin Cancer Res 15:6028-34. 2009
    ..However, the effect of tumor-stromal interactions on local estrogen biosynthesis in endometrial carcinomas remains largely unknown...
  6. doi request reprint MicroRNA-34b functions as a potential tumor suppressor in endometrial serous adenocarcinoma
    Eri Hiroki
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Int J Cancer 131:E395-404. 2012
    ..The expression of MET was reduced following the restoration of miR-34b in cell lines. In summary, our data suggest that miR-34b plays a role in the molecular pathogenesis of endometrial cancer...
  7. ncbi request reprint Progesterone receptor isoforms as a prognostic marker in human endometrial carcinoma
    Sumika Saito
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai 980 8574, Japan
    Cancer Sci 97:1308-14. 2006
    ..0258). The results of our study demonstrated that loss or absence of PR isoform expression determined by immunohistochemistry could become an important prognostic indicator in patients with endometrioid endometrial carcinoma...
  8. doi request reprint Expression of retinoic acid receptors in human endometrial carcinoma
    Kojiro Tanabe
    Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Sendai, Japan
    Cancer Sci 99:267-71. 2008
    ..AM580 might therefore be considered as a potential treatment for endometrial carcinoma...
  9. ncbi request reprint Expression of estrogen-responsive finger protein (Efp) is associated with advanced disease in human epithelial ovarian cancer
    Michiko Sakuma
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    Gynecol Oncol 99:664-70. 2005
    ..To understand the estrogenic action on ovarian cancer, we studied the relationships between Efp and ERs expressions and the correlations of Efp expression with clinicopathological parameters in epithelial ovarian cancer...
  10. ncbi request reprint Prognoses and prognostic factors of carcinosarcoma, endometrial stromal sarcoma and uterine leiomyosarcoma: a comparison with uterine endometrial adenocarcinoma
    Jun ichi Akahira
    Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Oncology 71:333-40. 2006
    ....
  11. ncbi request reprint Decreased expression of 14-3-3 sigma is associated with advanced disease in human epithelial ovarian cancer: its correlation with aberrant DNA methylation
    Jun ichi Akahira
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Clin Cancer Res 10:2687-93. 2004
    ..In this study, we examined the promoter methylation status and expression of 14-3-3 sigma and evaluated its clinical significance in epithelial ovarian cancer...
  12. ncbi request reprint Expression of organic cation transporter SLC22A16 in human epithelial ovarian cancer: a possible role of the adriamycin importer
    Kyoko Ota
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Int J Gynecol Pathol 26:334-40. 2007
    ..In conclusion, SLC22A16 was abundantly expressed in clear-cell adenocarcinoma. Our results suggest that adriamycin-related chemicals that are taken up via SLC22A16 may have the potential to be effective against clear-cell adenocarcinoma...
  13. ncbi request reprint Steroid sulfatase and estrogen sulfotransferase in human endometrial carcinoma
    Hiroki Utsunomiya
    Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Sendai, Japan
    Clin Cancer Res 10:5850-6. 2004
    ..However, the status of steroid sulfatase and/or estrogen sulfotransferase in human endometrial carcinoma has not been examined...
  14. doi request reprint Prospective study of sentinel lymph node biopsy without further pelvic lymphadenectomy in patients with sentinel lymph node-negative cervical cancer
    Hitoshi Niikura
    Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Sendai, Japan
    Int J Gynecol Cancer 22:1244-50. 2012
    ..The aim of the present study was to evaluate the incidence of lymphedema and cancer recurrence rate in patients with cervical cancer who undergo sentinel lymph node (SLN) biopsy alone in the absence of SLN metastases...
  15. doi request reprint Estrogen signaling ability in human endometrial cancer through the cancer-stromal interaction
    Mitsuyo Matsumoto
    Department of Medical Technology, Tohoku University School of Medicine, 2 1, Seiryo machi, Aoba ku, Sendai 981 0872, Japan
    Endocr Relat Cancer 15:451-63. 2008
    ..These results suggest that AI may have some therapeutic value in EC; however, the hormonal microenvironment must be assessed prior to initiating therapy...
  16. doi request reprint Loss of estrogen receptor beta isoform expression and its correlation with aberrant DNA methylation of the 5'-untranslated region in human epithelial ovarian carcinoma
    Fumihiko Suzuki
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    Cancer Sci 99:2365-72. 2008
    ..The results of our present study suggest that ERbeta is inactivated mainly through aberrant DNA methylation. This process may play an important role in the pathogenesis of epithelial ovarian cancer...
  17. doi request reprint Steroid and Xenobiotic Receptor (SXR) as a possible prognostic marker in epithelial ovarian cancer
    Xiaoni Yue
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Pathol Int 60:400-6. 2010
    ..Our data suggest that SXR is a prognostic factor in epithelial ovarian cancer and may represent a useful marker to identify patients at risk of recurrence or death...
  18. ncbi request reprint Decreased expression of RIZ1 and its clinicopathological significance in epithelial ovarian carcinoma: correlation with epigenetic inactivation by aberrant DNA methylation
    Jun ichi Akahira
    Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Pathol Int 57:725-33. 2007
    ..Reduced expression of RIZ1 may play an important role in the pathogenesis and/or development of epithelial ovarian carcinoma, and is considered to be caused in part by aberrant DNA methylation...
  19. ncbi request reprint 17Beta-hydroxysteroid dehydrogenases in human endometrium and its disorders
    Kiyoshi Ito
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Mol Cell Endocrinol 248:136-40. 2006
    ..These results indicated that 17-HSD types 2 and 5 play an important role in the regulation of in situ estrogen production in endometrial carcinoma...
  20. ncbi request reprint Biological roles of estrogen and progesterone in human endometrial carcinoma--new developments in potential endocrine therapy for endometrial cancer
    Kiyoshi Ito
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Endocr J 54:667-79. 2007
    ....
  21. doi request reprint Case-control study of coffee consumption and the risk of endometrial endometrioid adenocarcinoma
    Toshimitsu Koizumi
    Gynecology Division, Department of Reproductive and Developmental Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
    Eur J Cancer Prev 17:358-63. 2008
    ..90). This study thus revealed an inverse dose-response relationship between coffee consumption and the risk of EEA, and its strong association in postmenopausal women but not in premenopausal women...
  22. ncbi request reprint Relationship between ABCF2 expression and response to chemotherapy or prognosis in clear cell adenocarcinoma of the ovary
    Hiroshi Tsuda
    Department of Obstetrics and Gynecology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Int J Gynecol Cancer 20:794-7. 2010
    ....
  23. doi request reprint Midkine and its clinical significance in endometrial carcinoma
    Kojiro Tanabe
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    Cancer Sci 99:1125-30. 2008
    ..Additionally, preoperative serum MK levels are significantly correlated with prognosis and the presence of lymph node metastasis. Thus, MK may be a useful serum biomarker for identifying high risk patients of endometrial carcinoma...
  24. ncbi request reprint Small cell carcinoma of the uterine cervix: clinical outcome of concurrent chemoradiotherapy with a multidrug regimen
    Hideki Tokunaga
    Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Sendai, Miyagi, Japan
    Tohoku J Exp Med 229:75-81. 2013
    ..In particular, this combined modality therapy may improve both local control and survival as postoperative treatment in patients with early-stage disease...
  25. ncbi request reprint Hysteroscopic inspection and total curettage are insufficient for discriminating endometrial cancer from atypical endometrial hyperplasia
    Hiroki Kurosawa
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Tohoku J Exp Med 228:365-70. 2012
    ..Accordingly, we must be careful in planning the therapeutic strategy for women with a preoperative diagnosis of AEH...
  26. ncbi request reprint Ber-EP4 and anti-calretinin antibodies: a useful combination for differential diagnosis of various histological types of ovarian cancer cells and mesothelial cells
    Satoshi Okamoto
    Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Sendai, Japan
    Tohoku J Exp Med 206:31-40. 2005
    ....
  27. doi request reprint Detection of micrometastases in cervical cancer with a system that evaluates both sentinel and nonsentinel lymph nodes
    Satoshi Okamoto
    Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Sendai, Japan
    Int J Gynecol Cancer 19:708-11. 2009
    ..The SLNs detected by our method are probably real given the large total number of nodes evaluated. How micrometastases affect prognosis and the best way to detect them are areas of further study...
  28. ncbi request reprint Sentinel lymph node detection in early cervical cancer with combination 99mTc phytate and patent blue
    Hitoshi Niikura
    Department of Obstetrics and Gynecology, Tohoku University School of Medicine, 1 1 Seiryo machi, Sendai 980 8574, Japan
    Gynecol Oncol 94:528-32. 2004
    ....
  29. ncbi request reprint Detection of micrometastases in the sentinel lymph nodes of patients with endometrial cancer
    Hitoshi Niikura
    Department of Obstetrics and Gynecology, Tohoku University School of Medicine, 1 1, Seiryo machi, Sendai 980 8574, Japan
    Gynecol Oncol 105:683-6. 2007
    ..We reevaluated the accuracy of our SLN detection procedure, this time combining step-serial section with cytokeratin immunostaining...
  30. doi request reprint Roles of intrinsic angiogenesis inhibitor, vasohibin, in cervical carcinomas
    Kousuke Yoshinaga
    Department of Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Cancer Sci 102:446-51. 2011
    ..05, r(2) = 0.3018). This is the first study to elucidate the correlation between the expression of vasohibin in the stromal endothelial cells and the expression of VEGFR-2 in human cervical carcinomas...
  31. doi request reprint Differential expression of hypoxia-inducible protein 2 among different histological types of epithelial ovarian cancer and in clear cell adenocarcinomas
    Sadako Nishimura
    Department of Obstetrics and Gynecology, Osaka City General Hospital, Osaka, Japan
    Int J Gynecol Cancer 20:220-6. 2010
    ..In this study, we generated a polyclonal antiserum to HIG2 to explore the use of HIG2 as a predictive biomarker in EOC. In addition, HIG2 expression was evaluated in uterine endometrial and renal CCCs...
  32. ncbi request reprint Differential expression of progesterone receptor isoforms A and B in the normal ovary, and in benign, borderline, and malignant ovarian tumors
    Jun ichi Akahira
    Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Aoba ku, Sendai 980 8574, Japan
    Jpn J Cancer Res 93:807-15. 2002
    ..These results suggest that down-regulation of PRA is associated with the development of ovarian epithelial carcinoma...
  33. ncbi request reprint Peroxisome proliferator-activated receptor gamma and growth inhibition by its ligands in uterine endometrial carcinoma
    Kyoko Ota
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Clin Cancer Res 12:4200-8. 2006
    ..In this study, we evaluated the correlation between endometrial carcinoma and peroxisome proliferator-activated receptor gamma (PPARgamma) expression and assessed whether PPARgamma ligands influence carcinoma growth...
  34. doi request reprint Clinicopathological significance of circadian rhythm-related gene expression levels in patients with epithelial ovarian cancer
    Hideki Tokunaga
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Acta Obstet Gynecol Scand 87:1060-70. 2008
    ..In this study, we measured the expression levels of clock genes and correlated their expression levels with clinicopathological parameters in epithelial ovarian cancer...
  35. ncbi request reprint Malignant transformation arising from mature cystic teratoma of the ovary: a retrospective study of 20 cases
    Michiko Sakuma
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 9808574, Japan
    Int J Gynecol Cancer 20:766-71. 2010
    ..The rarity of this tumor has posed a significant challenge to developing standardized postoperative management protocols. The aim of this study was to review our experience with MT and to describe our current treatment practices...
  36. ncbi request reprint Impact of serum interleukin-18 level as a prognostic indicator in patients with epithelial ovarian carcinoma
    Jun ichi Akahiro
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    Int J Clin Oncol 9:42-6. 2004
    ..In this study, for the first time, the serum concentration of IL-18 and its significance as a prognostic indicator was evaluated in patients with epithelial ovarian cancer...
  37. ncbi request reprint Surgical anatomy of intrapelvic fasciae and vesico-uterine ligament in nerve-sparing radical hysterectomy with fresh cadaver dissections
    Hitoshi Niikura
    Department of Gynecology and Obstetrics, Tohoku University School of Medicine, Sendai, Japan
    Tohoku J Exp Med 212:403-13. 2007
    ..Translation of surgical anatomy into anatomic terminology enables us to have fruitful discussions with persuasive power by excluding any bias from individual surgeons...
  38. ncbi request reprint Retrospective analysis of concurrent chemoradiation with the combination of bleomycin, ifosfamide and cisplatin (BIP) for uterine cervical cancer
    Michiko Aoki
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai 980 8574, Japan
    Tohoku J Exp Med 204:309-15. 2004
    ..7%) of patients, with a response rate of 90.9%. In conclusion, BIP chemoradiation seems to be superior to previously reported chemoradiation regimens, and has a potential as an optimal combination chemotherapy concurrent with radiation...
  39. ncbi request reprint Lactation and risk of endometrial cancer in Japan: a case-control study
    Chikako Okamura
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Tohoku J Exp Med 208:109-15. 2006
    ..In conclusion, the present study has indicated that breastfeeding reduces the risk of endometrial cancer in Japanese women...
  40. doi request reprint Case-control study of green tea consumption and the risk of endometrial endometrioid adenocarcinoma
    Yukika Kakuta
    Division of Gynecology, Department of Reproductive and Developmental Medicine, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    Cancer Causes Control 20:617-24. 2009
    ..To investigate the association between green tea consumption and the risk of endometrial cancer restricted to endometrial endometrioid adenocarcinoma (EEA) using a case-control design in Japan...
  41. doi request reprint Expression of vasohibin as a novel endothelium-derived angiogenesis inhibitor in endometrial cancer
    Kousuke Yoshinaga
    Department of Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Cancer Sci 99:914-9. 2008
    ..0001, r(2) = 0.591). This is the first study to elucidate the correlation between expression of vasohibin in the stromal endothelial cells and that of VEGFR-2 in human carcinomas...
  42. ncbi request reprint Ovarian epithelial carcinoma with estrogen-producing stroma
    Hideki Tokunaga
    Department of Obstetrics and Gynecology, Tohuku University School of Medicine, Sendai, Japan
    Pathol Int 57:285-90. 2007
    ....
  43. ncbi request reprint Expression of organic cation transporter SLC22A16 in human endometria
    Naoko Sato
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Int J Gynecol Pathol 26:53-60. 2007
    ..Our findings also suggest that it may be possible to use progestins to increase the response of endometrioid endometrial carcinoma with SLC22A16 expression to adriamycin-based chemotherapeutic regimens...
  44. ncbi request reprint Phase I trial of concurrent chemoradiation with weekly nedaplatin in patients with squamous cell carcinoma of the uterine cervix
    Kohsuke Yoshinaga
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai 980 8574, Japan
    Gynecol Oncol 104:36-40. 2007
    ....
  45. ncbi request reprint Smoking, earlier menarche and low parity as independent risk factors for gynecologic cancers in Japanese: a case-control study
    Megumi Fujita
    Gynecology Division, Department of Reproductive and Developmental Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
    Tohoku J Exp Med 216:297-307. 2008
    ..The increase in female smokers and the decrease in fertility rate may contribute to the increase in gynecologic cancer incidence in Japan...
  46. doi request reprint Steroid sulfatase and estrogen sulfotransferase in human carcinomas
    Takashi Suzuki
    Department of Pathology and Histotechnology, Tohoku University, Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Mol Cell Endocrinol 340:148-53. 2011
    ..Therefore, STS pathway and estrogen actions may play an important role in the development of these carcinomas, and further investigations are required...
  47. ncbi request reprint The correlation between the response to progestogen treatment and the expression of progesterone receptor B and 17beta-hydroxysteroid dehydrogenase type 2 in human endometrial carcinoma
    Hiroki Utsunomiya
    Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Sendai, Japan
    Clin Endocrinol (Oxf) 58:696-703. 2003
    ..However, details of the alterations of in situ oestrogen metabolism following progestogen treatment have yet to be fully elucidated...
  48. ncbi request reprint Clinical experience with combination paclitaxel and carboplatin therapy for advanced or recurrent carcinosarcoma of the uterus
    Masafumi Toyoshima
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Gynecol Oncol 94:774-8. 2004
    ..The purpose of the study was to evaluate the efficacy of combination chemotherapy with paclitaxel and carboplatin in patients with advanced or recurrent carcinosarcoma of the uterus...
  49. ncbi request reprint Lymphadenectomy for endometrial cancer: is paraaortic lymphadenectomy necessary?
    Nobuo Yaegashi
    Department of Obstetrics and Gynecology, Tohoku University, Graduate School of Medicine, Sendai, 980 8574, Japan
    Int J Clin Oncol 12:176-80. 2007
    ..At present, the addition of PA lymphadenectomy for endometrial cancer can be regarded as only an investigated protocol...
  50. doi request reprint Changes in microRNA expression levels correlate with clinicopathological features and prognoses in endometrial serous adenocarcinomas
    Eri Hiroki
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Cancer Sci 101:241-9. 2010
    ..035). These findings suggest that the dysregulation of miRNAs is associated with the poor prognosis in endometrial serous adenocarcinoma patients...
  51. ncbi request reprint Promoter methylation status and expression of TMS1 gene in human epithelial ovarian cancer
    Jun ichi Akahira
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Aoba ku, Sendai 980 8574, Japan
    Cancer Sci 95:40-3. 2004
    ..Our results suggest that aberrant methylation of TMS1 may play a role in the pathogenesis of ovarian cancer...
  52. ncbi request reprint Expression of androgen receptor and 5alpha-reductases in the human normal endometrium and its disorders
    Kiyoshi Ito
    Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Sendai, Japan
    Int J Cancer 99:652-7. 2002
    ..Androgenic actions may be also regulated predominantly by serum testosterone and not by DHT in endometrial hyperplasia because of the absence of 5alpha-reductases in the site of its actions...
  53. ncbi request reprint A case of primary mucosa-associated lymphoid tissue lymphoma of the vagina
    Kousuke Yoshinaga
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Hum Pathol 35:1164-6. 2004
    ..The patient is alive and well 40 months after treatment. Because the vagina is one of the mucosa-associated tissues, MALT lymphoma, though rare, must be included in the differential diagnosis of the vaginal neoplasms...
  54. ncbi request reprint Carboplatin-based chemotherapy in patients with gynecological malignancies on long-term hemodialysis
    Hitoshi Niikura
    Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Sendai, Japan
    Anticancer Drugs 14:735-8. 2003
    ..Our findings suggest these regimens are feasible, and the combination of paclitaxel and carboplatin is effective chemotherapy when administered to long-term hemodialysis patients with recurrent endometrial carcinoma...
  55. ncbi request reprint Clinical manifestations and outcomes of parvovirus B19 infection during pregnancy in Japan
    Hiroshi Chisaka
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Tohoku J Exp Med 209:277-83. 2006
    ..These clinical data may supply useful information to produce clinical guidelines for managing B19 infection during pregnancy...
  56. ncbi request reprint Cervical cytologic examination during physical checkup of pregnant women: cervical cancer screening in women under the age of thirty
    Yoriko Abe
    Department of Obstetrics and Gynecology, Tohoku University, Sendai 980 8574, Japan
    Tohoku J Exp Med 204:221-8. 2004
    ..Our results suggest that screening for cervical cancer in pregnancy is a useful means to find cervical neoplasia in young women and is effective in reducing the cervical cancer morbidity rate...
  57. doi request reprint Individualized radical hysterectomy procedure using intraoperative electrical stimulation for patients with cervical cancer
    Tomoyuki Nagai
    Department of Obstetrics and Gynecology, TohokuUniversity School of Medicine, 1 1 Seiryo machi, Sendai, Japan
    Int J Gynecol Cancer 22:1591-6. 2012
    ....
  58. ncbi request reprint Prognostic significance of second-look laparotomy for surgically confirmed early-stage epithelial ovarian cancer: a multicenter retrospective study
    Naoko Sato
    Department of Obstetrics and Gynecology, Tohoku University School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    Int J Clin Oncol 8:40-4. 2003
    ..In the present study, we conducted a multicenter retrospective analysis to elucidate the prognostic significance of second-look laparotomy (SLL) in early-stage epithelial ovarian cancer that was confirmed by complete surgical exploration...
  59. ncbi request reprint Differential expression of ABCF2 protein among different histologic types of epithelial ovarian cancer and in clear cell adenocarcinomas of different organs
    Sadako Nishimura
    Department of Obstetrics and Gynecology, Osaka City General Hospital, Miyakojima, Osaka 534 0021, Japan
    Hum Pathol 38:134-9. 2007
    ..0001). These data suggest that ABCF2 protein may be a candidate marker for clear cell adenocarcinomas of the ovary and the uterine corpus and may be important for the pathogenesis of these diseases...
  60. ncbi request reprint Sentinel lymph node detection in patients with endometrial cancer
    Hitoshi Niikura
    Department of Obstetrics and Gynecology, Tohoku University School of Medicine 1 1, Seiryo machi, Sendai 980 8574, Japan
    Gynecol Oncol 92:669-74. 2004
    ..The purpose of this study was to examine the feasibility of sentinel lymph node (SLN) detection in patients with endometrial cancer using preoperative lymphoscintigraphy and an intraoperative gamma probe...
  61. ncbi request reprint Use of Mammalian eggs for assessment of human sperm function: molecular and cellular analyses of fertilization by intracytoplasmic sperm injection
    Yukihiro Terada
    Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Sendai, Miyagi, Japan
    Am J Reprod Immunol 51:290-3. 2004
    ..Egg activation, sperm decondensation and sperm centorosomal function were examined in sperm from fertile men and infertile patients...
  62. ncbi request reprint Sex steroid-producing enzymes in human breast cancer
    Takashi Suzuki
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    Endocr Relat Cancer 12:701-20. 2005
    ....
  63. ncbi request reprint Gastrointestinal immunophenotype in adenocarcinomas of the uterine cervix and related glandular lesions: a possible link between lobular endocervical glandular hyperplasia/pyloric gland metaplasia and 'adenoma malignum'
    Yoshiki Mikami
    Department of Pathology, Tohoku University Graduate School of Medical Science, Sendai, Japan
    Mod Pathol 17:962-72. 2004
    ..p16INK4 immunohistochemistry appears to be a promising diagnostic tool, but pathologists should be aware of frequent negative staining in MDAs, which can be a source of erroneous diagnosis...
  64. doi request reprint Association of keap1 and nrf2 genetic mutations and polymorphisms with endometrioid endometrial adenocarcinoma survival
    Tze Fang Wong
    Department of Gynecology, Tohoku University Graduate School of Medicine, Japan
    Int J Gynecol Cancer 21:1428-35. 2011
    ..To understand the role of Keap1 and Nrf2 in endometrial cancer, we performed DNA sequencing of tumors and noted the relation of the DNA sequence with annotated clinicopathologic data...
  65. ncbi request reprint Immunolocalization of nuclear transcription factors, DAX-1 and COUP-TF II, in the normal human ovary: correlation with adrenal 4 binding protein/steroidogenic factor-1 immunolocalization during the menstrual cycle
    Yoko Sato
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    J Clin Endocrinol Metab 88:3415-20. 2003
    ..These results indicated that DAX-1 and COUP-TFII may play a role in the modulation of Ad4BP/SF-1-dependent transcription of steroidogenic enzymes in different cell types and follicular stages in normal cycling human ovaries...
  66. ncbi request reprint Management of ovarian hyperstimulation due to follicle-stimulating hormone-secreting gonadotroph adenoma
    Takashi Murakami
    Department of Obstetrics and Gynaecology, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    BJOG 111:1297-300. 2004
  67. doi request reprint Evidence-based guidelines for treatment of uterine body neoplasm in Japan: Japan Society of Gynecologic Oncology (JSGO) 2009 edition
    Satoru Nagase
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    Int J Clin Oncol 15:531-42. 2010
    ..The treatment recommendations herein are tailored to reflect current Japanese clinical practice and ensure equitable care for all Japanese women diagnosed with endometrial cancer...
  68. pmc E4F1, a novel estrogen-responsive gene in possible atheroprotection, revealed by microarray analysis
    Yasuhiro Nakamura
    Department of Pathology, Tohoku University School of Medicine, Aoba ku, Sendai 980 8575, Japan
    Am J Pathol 165:2019-31. 2004
    ..E4F1 is therefore considered one of the estrogen-responsive genes involving ER alpha-mediated inhibition of VSMC proliferation and may play an important role in estrogen-related atheroprotection of human aorta...
  69. ncbi request reprint Epithelioid leiomyosarcoma of the uterine cervix: a case report and review of the literature
    Masafumi Toyoshima
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba, Sendai 980 8574, Japan
    Gynecol Oncol 97:957-60. 2005
    ..Epithelioid leiomyosarcomas arising from the uterine cervix are extremely rare neoplasms, with only three cases reported in the English literature...
  70. ncbi request reprint Isolated torsion of the distal part of the fallopian tube in a premenarcheal 12 year old girl: a case report
    Yukihiro Terada
    Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Sendai 980 8574, Japan
    Tohoku J Exp Med 202:239-43. 2004
    ..Laparoscopic inspection/surgery appears to be the most suitable management...
  71. doi request reprint Evidence-based guidelines for treatment of cervical cancer in Japan: Japan Society of Gynecologic Oncology (JSGO) 2007 edition
    Satoru Nagase
    Department of Obstetrics and Gynecology, Graduate School of Medicine, Tohoku University, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    Int J Clin Oncol 15:117-24. 2010
    ..The objective of these guidelines is to clearly delineate the standard of care for cervical cancer treatment in Japan in order to ensure equitable care for all Japanese women diagnosed with cervical cancer...
  72. ncbi request reprint Pleurotolysin, a novel sphingomyelin-specific two-component cytolysin from the edible mushroom Pleurotus ostreatus, assembles into a transmembrane pore complex
    Toshio Tomita
    Department of Microbial Biotechnology, Graduate School of Agricultural Science, Tohoku University, Aoba ku, Sendai 981 8555, Japan
    J Biol Chem 279:26975-82. 2004
    ..Pleurotolysin A and B formed an SDS-stable, ring-shaped complex of the same dimensions on sphingomyelin-cholesterol liposomes as well...
  73. ncbi request reprint Promoter methylation status of the Cyclin D2 gene is associated with poor prognosis in human epithelial ovarian cancer
    Michiko Sakuma
    Department of Obstetrics and Gynecology, Tohoku University, Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku Sendai, 980 8574 Japan
    Cancer Sci 98:380-6. 2007
    ..021). Our results suggest that aberrant promoter methylation of the Cyclin D2 gene is significantly associated with patient prognosis in epithelial ovarian cancer...
  74. doi request reprint Optimal defense strategy against herbivory in plants: conditions selecting for induced defense, constitutive defense, and no-defense
    Kiyoshi Ito
    Department of Ecology and Evolutionary Biology, Graduate School of Life Sciences, Tohoku University, Aoba, Sendai 980 8578, Japan
    J Theor Biol 260:453-9. 2009
    ..If the probability stays the same, no-defense is optimal. Thus, the behavior of herbivores, i.e., whether they remain around a plant and attack it repeatedly, affects the evolution of the induced defense...
  75. ncbi request reprint Expression of copper-transporting P-type adenosine triphosphatase (ATP7B) as a prognostic factor in human endometrial carcinoma
    Takeshi Aida
    Department of Surgery II, Fukushima Medical University, Fukushima, Hikarigaoka 1, 960 1295, Japan
    Gynecol Oncol 97:41-5. 2005
    ..Our goal was to investigate if ATP7B is expressed in endometrial carcinoma and whether its expression correlates with prognosis...
  76. ncbi request reprint [Endometrial carcinoma]
    Satoru Nagase
    Department of Gynecology, Tohoku University Graduate School of Medicine
    Nihon Rinsho . 2006
  77. ncbi request reprint A clinical comparison of unrelated cord blood transplantation and unrelated bone marrow transplantation for adult patients with acute leukaemia in complete remission
    Jun Ooi
    Department of Haematology and Oncology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Br J Haematol 118:140-3. 2002
    ..The probability of 2 year disease-free survival was similar between the two groups. These results suggest that adult acute leukaemia patients in CR without a suitable donor should be considered as candidates for UCBT...
  78. ncbi request reprint [Structural and functional analysis of enzymes and their application to clinical analysis--study on Pseudomonas putida formaldehyde dehydrogenase]
    Kiyoshi Ito
    Department of Molecular Medicinal Sciences, Division of Biotechnology, 1 14 Bunkyo machi, Nagasaki 852 8521, Japan
    Yakugaku Zasshi 122:805-11. 2002
    ..However, a comparison of these structures indicated that the insertion loop specifically found in PFDH may be responsible for the tight binding of the cofactor, thereby making PFDH a dismutase...
  79. ncbi request reprint Successful unrelated cord blood transplantation for relapse after autologous transplantation in non-Hodgkin's lymphoma
    Jun Ooi
    Department of Hematology and Oncology, Institute of Medical Science, University of Tokyo, Japan
    Leuk Lymphoma 43:653-5. 2002
    ..After a follow-up period of 16 months, the patient is alive and free of disease. To our knowledge this is the first report of a successful unrelated CBT for an adult NHL patient who relapsed after autologous transplantation...
  80. ncbi request reprint Novel inhibitor for prolyl aminopeptidase from Serratia marcescens and studies on the mechanism of substrate recognition of the enzyme using the inhibitor
    Takahiko Inoue
    Graduate School of Biomedical Sciences, Nagasaki University, 1 14 Bunkyo machi, Nagasaki 852 8521, Japan
    Arch Biochem Biophys 416:147-54. 2003
    ....
  81. ncbi request reprint Novel inhibitor for prolyl tripeptidyl aminopeptidase from Porphyromonas gingivalis and details of substrate-recognition mechanism
    Yue Xu
    Graduate School of Biomedical Sciences, Nagasaki University, 1 14 Bunkyo machi, Nagasaki 852 8521, Japan
    J Mol Biol 375:708-19. 2008
    ..8 microM, which was 554-fold higher than that against the wild-type enzyme. Consequently, it was concluded that Glu205 and Glu636 are significant residues for the N-terminal recognition of a substrate...
  82. ncbi request reprint Crystal structure and mechanism of tripeptidyl activity of prolyl tripeptidyl aminopeptidase from Porphyromonas gingivalis
    Kiyoshi Ito
    Gradute School of Biomedical Sciences, Nagasaki University 1 14 Bunkyo machi, Nagasaki 852 8521, Japan
    J Mol Biol 362:228-40. 2006
    ..The loop structure provides sufficient space to accommodate three N-terminal residues (Xaa-Xaa-Pro) of substrates. This is the first report of the structure and substrate recognition mechanism of tripeptidyl peptidase...
  83. ncbi request reprint D-3-hydroxybutyrate dehydrogenase from Pseudomonas fragi: molecular cloning of the enzyme gene and crystal structure of the enzyme
    Kiyoshi Ito
    Department of Molecular Medicinal Sciences, Graduate School of Biomedical Sciences, Nagasaki University, 1 14 Bunkyo machi, Nagasaki 852 8521, Japan
    J Mol Biol 355:722-33. 2006
    ..6 mM. From the interactions between cacodylate and the enzyme, it is predicted that substrate specificity is achieved through the recognition of the 3-methyl and carboxyl groups of the substrate...
  84. ncbi request reprint Second allogeneic hematopoietic stem cell transplantation for leukemia relapse after first allogeneic transplantation: outcome of 16 patients in a single institution
    Akira Tomonari
    Department of Hematology Oncology, The Institute of Medical Science, The University of Tokyo, Japan
    Int J Hematol 75:318-23. 2002
    ..HSCT2 is considered to be beneficial for select patients. Preparative regimens, GVHD prophylaxis, and donor choice for HSCT2 need to be studied to obtain a more successful outcome for HSCT2...
  85. ncbi request reprint High expression of unsaturated fatty acid synthesis gene OLE 1 in sake yeasts
    Tasuku Yamada
    General Research Laboratory of Kiku Masamune Sake Brewing Co Ltd, 1 8 6 Uozaki Nishimachi, Higasinada ku, Kobe 658 0026, Japan
    J Biosci Bioeng 99:512-6. 2005
    ..Experiments using OLE 1 promoter:lacZ fusion reporter genes revealed that both the cis element of the OLE 1 promoter and trans factors are involved in the increased expression of OLE 1 in sake yeasts...