Yuzuru Imai

Summary

Affiliation: Tohoku University
Country: Japan

Publications

  1. pmc The loss of PGAM5 suppresses the mitochondrial degeneration caused by inactivation of PINK1 in Drosophila
    Yuzuru Imai
    Institute of Development, Aging, and Cancer, Tohoku University, Sendai, Japan
    PLoS Genet 6:e1001229. 2010
  2. pmc Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila
    Yuzuru Imai
    Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    EMBO J 27:2432-43. 2008
  3. ncbi request reprint Pael receptor is involved in dopamine metabolism in the nigrostriatal system
    Yuzuru Imai
    Laboratory for Motor System Neurodegeneration, RIKEN Brain Science Institute BSI, Saitama, Japan
    Neurosci Res 59:413-25. 2007
  4. ncbi request reprint A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death
    Yuzuru Imai
    Laboratory for Motor System Neurodegeneration, RIKEN Brain Science Institute, Saitama 351 0198, Japan
    J Biol Chem 278:51901-10. 2003
  5. doi request reprint Activation of FoxO by LRRK2 induces expression of proapoptotic proteins and alters survival of postmitotic dopaminergic neuron in Drosophila
    Tomoko Kanao
    Institute of Development, Aging and Cancer, Tohoku University, 4 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Hum Mol Genet 19:3747-58. 2010
  6. ncbi request reprint Pael receptor, endoplasmic reticulum stress, and Parkinson's disease
    Ryosuke Takahashi
    Laboratory of Motor Neurodegeneration, RIKEN Brain Science Institute BSI, 2 1 Hirosawa, Wako, 351 0198, Saitama, Japan
    J Neurol 250:III25-9. 2003
  7. ncbi request reprint [Frontier researches for the development of molecular-targeted therapies for familial Parkinson disease]
    Yuzuru Imai
    Institute of Development, Aging and Cancer, Tohoku University, 4 1 Seiryo machi, Aoba ku, Sendai, Miyagi 980 8575, Japan
    Brain Nerve 61:903-13. 2009
  8. ncbi request reprint CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity
    Yuzuru Imai
    Laboratory for Motor System Neurodegeneration, RIKEN Brain Science Institute, Saitama 351 0198, Japan
    Mol Cell 10:55-67. 2002
  9. ncbi request reprint In vivo evidence of CHIP up-regulation attenuating tau aggregation
    Naruhiko Sahara
    Laboratory for Alzheimer s Disease, RIKEN Brain Science Institute, Saitama, Japan
    J Neurochem 94:1254-63. 2005
  10. ncbi request reprint Parkin and endoplasmic reticulum stress
    Ryosuke Takahashi
    Laboratory for Motor System Neurodegeneration, RIKEN Brain Science Institute, Saitama 351 0198, Japan
    Ann N Y Acad Sci 991:101-6. 2003

Collaborators

Detail Information

Publications24

  1. pmc The loss of PGAM5 suppresses the mitochondrial degeneration caused by inactivation of PINK1 in Drosophila
    Yuzuru Imai
    Institute of Development, Aging, and Cancer, Tohoku University, Sendai, Japan
    PLoS Genet 6:e1001229. 2010
    ..These results suggest that PGAM5 negatively regulates the PINK1 pathway related to maintenance of the mitochondria and, furthermore, that PGAM5 acts between PINK1 and Parkin, or functions independently of Parkin downstream of PINK1...
  2. pmc Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila
    Yuzuru Imai
    Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    EMBO J 27:2432-43. 2008
    ..Our results suggest that chronic inactivation of 4E-BP by LRRK2 with pathogenic mutations deregulates protein translation, eventually resulting in age-dependent loss of DA neurons...
  3. ncbi request reprint Pael receptor is involved in dopamine metabolism in the nigrostriatal system
    Yuzuru Imai
    Laboratory for Motor System Neurodegeneration, RIKEN Brain Science Institute BSI, Saitama, Japan
    Neurosci Res 59:413-25. 2007
    ..These results strongly suggest that the Pael-R signal regulates the amount of DA in the dopaminergic neurons and that excessive Pael-R expression renders dopaminergic neurons susceptible to chronic DA toxicity...
  4. ncbi request reprint A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death
    Yuzuru Imai
    Laboratory for Motor System Neurodegeneration, RIKEN Brain Science Institute, Saitama 351 0198, Japan
    J Biol Chem 278:51901-10. 2003
    ..These data suggest that Glup may play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson's disease...
  5. doi request reprint Activation of FoxO by LRRK2 induces expression of proapoptotic proteins and alters survival of postmitotic dopaminergic neuron in Drosophila
    Tomoko Kanao
    Institute of Development, Aging and Cancer, Tohoku University, 4 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Hum Mol Genet 19:3747-58. 2010
    ..These data suggest that the cell death molecules regulated by FoxO are key factors during the neurodegeneration in LRRK2-linked PD...
  6. ncbi request reprint Pael receptor, endoplasmic reticulum stress, and Parkinson's disease
    Ryosuke Takahashi
    Laboratory of Motor Neurodegeneration, RIKEN Brain Science Institute BSI, 2 1 Hirosawa, Wako, 351 0198, Saitama, Japan
    J Neurol 250:III25-9. 2003
    ..We found that CHIP enhanced parkinmediated ubiquitination of Pael-R. In concert with Hsp70, CHIP also enhanced the ability of parkin to inhibit cell death induced by Pael-R, indicating that CHIP and Hsp70 are both co-factors of parkin...
  7. ncbi request reprint [Frontier researches for the development of molecular-targeted therapies for familial Parkinson disease]
    Yuzuru Imai
    Institute of Development, Aging and Cancer, Tohoku University, 4 1 Seiryo machi, Aoba ku, Sendai, Miyagi 980 8575, Japan
    Brain Nerve 61:903-13. 2009
    ....
  8. ncbi request reprint CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity
    Yuzuru Imai
    Laboratory for Motor System Neurodegeneration, RIKEN Brain Science Institute, Saitama 351 0198, Japan
    Mol Cell 10:55-67. 2002
    ..Furthermore, CHIP enhanced the ability of Parkin to inhibit cell death induced by Pael-R. Taken together, these results indicate that CHIP is a mammalian E4-like molecule that positively regulates Parkin E3 activity...
  9. ncbi request reprint In vivo evidence of CHIP up-regulation attenuating tau aggregation
    Naruhiko Sahara
    Laboratory for Alzheimer s Disease, RIKEN Brain Science Institute, Saitama, Japan
    J Neurochem 94:1254-63. 2005
    ..If confirmed, this would indicate that the quality-control machinery in a neuron might play an important role in retarding the pathogenesis of tauopathies...
  10. ncbi request reprint Parkin and endoplasmic reticulum stress
    Ryosuke Takahashi
    Laboratory for Motor System Neurodegeneration, RIKEN Brain Science Institute, Saitama 351 0198, Japan
    Ann N Y Acad Sci 991:101-6. 2003
    ..In conclusion, we showed that the accumulation of unfolded Pael receptor (a substrate of parkin) may cause selective death of dopaminergic neurons in AR-JP...
  11. ncbi request reprint How do Parkin mutations result in neurodegeneration?
    Yuzuru Imai
    Motor System Neurodegeneration, RIKEN Brain Science Institute BSI, Saitama 351 0198, Japan
    Curr Opin Neurobiol 14:384-9. 2004
    ..Further investigation of Parkin knockout mice will hopefully provide new evidence in the search for Parkin's substrates and further clarify their role in Parkinson's disease...
  12. ncbi request reprint [Parkin protein and molecular mechanism of Parkinson's disease]
    Yuzuru Imai
    Nihon Ronen Igakkai Zasshi 41:619-21. 2004
  13. ncbi request reprint Pael-R is accumulated in Lewy bodies of Parkinson's disease
    Tetsuro Murakami
    Department of Neurology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Ann Neurol 55:439-42. 2004
    ..The absence of Pael-R and Parkin in glial cytoplasmic inclusions (GCIs) in MSA implies a distinct pathway involved in the formation of LBs and GCIs...
  14. ncbi request reprint [Dopaminergic neuronal death in Parkinson's disease: is accumulation of unfolded proteins a cause or effect?]
    Yuzuru Imai
    Tanpakushitsu Kakusan Koso 49:1113-7. 2004
  15. ncbi request reprint Activation of PAR-1 kinase and stimulation of tau phosphorylation by diverse signals require the tumor suppressor protein LKB1
    Ji Wu Wang
    Department of Pathology, Stanford University School of Medicine, and Geriatric Research, Education, and Clinical Center Veterans Affairs Palo Alto Health Care System, Palo Alto, California 94304, USA
    J Neurosci 27:574-81. 2007
    ..These results reveal a new function for the tumor suppressor protein LKB1 in a signaling cascade through which the phosphorylation and function of tau is regulated by diverse signals under physiological and pathological conditions...
  16. ncbi request reprint Pael receptor induces death of dopaminergic neurons in the substantia nigra via endoplasmic reticulum stress and dopamine toxicity, which is enhanced under condition of parkin inactivation
    Yasuko Kitao
    Department of Neuroanatomy, Kanazawa University Medical School, 13 1, Takara machi, Kanazawa City, 920 8640 Ishikawa, Japan
    Hum Mol Genet 16:50-60. 2007
    ..These data suggest a model in which ER- and dopamine-related stress are major contributors to decreased viability of dopaminergic neurons in a setting relevant to Parkinson's disease...
  17. pmc Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin
    Yufeng Yang
    Department of Pathology and Geriatric Research, Education and Clinical Center Veterans Affairs Palo Alto Health Care System, Stanford University School of Medicine, Palo Alto, CA 94304, USA
    Proc Natl Acad Sci U S A 103:10793-8. 2006
    ..Together, these results implicate Pink1 and Parkin in a common pathway that regulates mitochondrial physiology and cell survival in Drosophila...
  18. pmc Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling
    Yufeng Yang
    Department of Pathology, Stanford University School of Medicine, and Geriatric Research, Education and Clinical Center Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304, USA
    Proc Natl Acad Sci U S A 102:13670-5. 2005
    ..Manipulation of PI3K/Akt signaling may therefore offer therapeutic benefits for the treatment of PD...
  19. ncbi request reprint Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila
    Yufeng Yang
    Laboratory of Developmental Neurobiology, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Neuron 37:911-24. 2003
    ..Our study implicates Parkin as a central player in the molecular pathway of Parkinson's disease (PD) and suggests that manipulating Parkin expression may provide a novel avenue of PD therapy...
  20. doi request reprint Pael-R transgenic mice crossed with parkin deficient mice displayed progressive and selective catecholaminergic neuronal loss
    Hua Qin Wang
    Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Neurochem 107:171-85. 2008
    ..parkin-ko/Pael-R-tg mice represents an AR-JP mouse model displaying chronic and selective loss of catecholaminergic neurons...
  21. doi request reprint Rines/RNF180, a novel RING finger gene-encoded product, is a membrane-bound ubiquitin ligase
    Miyuki Ogawa
    Laboratory for Comparative Neurogenesis, RIKEN Brain Science Institute, Wako Shi, Saitama 351 0198, Japan
    Genes Cells 13:397-409. 2008
    ..These results suggest that Rines is a membrane-bound E3 ubiquitin ligase...
  22. ncbi request reprint Cell type-specific upregulation of Parkin in response to ER stress
    Hua Qin Wang
    Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Antioxid Redox Signal 9:533-42. 2007
    ..Luciferase assays failed to detect the transcriptional activation of 500 bp parkin/Glup promoter in response to ER stress. These results indicate that induction of parkin by ER stress represents a cell type-specific response...
  23. ncbi request reprint Parkin phosphorylation and modulation of its E3 ubiquitin ligase activity
    Ayako Yamamoto
    Laboratory of Alzheimer s and Parkinson s Disease Research, Department of Metabolic Biochemistry, Ludwig Maximilians University, 80336 Munich, Germany
    J Biol Chem 280:3390-9. 2005
    ..Thus, complex regulation of the phosphorylation state of parkin may contribute to the unfolded protein response in stressed cells...
  24. ncbi request reprint The neuropeptide head activator is a high-affinity ligand for the orphan G-protein-coupled receptor GPR37
    Meriem Rezgaoui
    Zentrum fur Molekulare Neurobiologie Hamburg, Universitatsklinikum Hamburg Eppendorf, Martinistr 52, 20246 Hamburg, Germany
    J Cell Sci 119:542-9. 2006
    ....