Tsuyoshi Ikura

Summary

Affiliation: Tohoku University
Country: Japan

Publications

  1. ncbi [Dynamic organization of chromatin in DNA repair]
    Tsuyoshi Ikura
    Tanpakushitsu Kakusan Koso 51:310-4. 2006
  2. ncbi [Role of histone variant in DNA metabolism]
    Tsuyoshi Ikura
    Tanpakushitsu Kakusan Koso 51:2083-5. 2006
  3. pmc DNA damage-dependent acetylation and ubiquitination of H2AX enhances chromatin dynamics
    Tsuyoshi Ikura
    Department of Biochemistry, Tohoku University Graduate School of Medicine, Seiryoumachi 2 1, Aobaku Sendai 980 8575, Japan
    Mol Cell Biol 27:7028-40. 2007
  4. pmc A novel interplay between the Fanconi anemia core complex and ATR-ATRIP kinase during DNA cross-link repair
    Junya Tomida
    Department of Late Effects Studies, Laboratory of DNA Damage Signaling, Kyoto University, Kyoto 606 8501, Japan, Japan Society for the Promotion of Science JSPS, Tokyo 102 0083, Japan
    Nucleic Acids Res 41:6930-41. 2013
  5. doi Bach1-mediated suppression of p53 is inhibited by p19(ARF) independently of MDM2
    Hironari Nishizawa
    Department of Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan
    Cancer Sci 103:897-903. 2012
  6. doi Methionine adenosyltransferase II serves as a transcriptional corepressor of Maf oncoprotein
    Yasutake Katoh
    Department of Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Miyagi 980 8575, Japan
    Mol Cell 41:554-66. 2011
  7. ncbi Bach1 inhibits oxidative stress-induced cellular senescence by impeding p53 function on chromatin
    Yoshihiro Dohi
    Department of Biochemistry, Tohoku University Graduate School of Medicine, Seiryo machi 2 1, Sendai 980 8575, Japan
    Nat Struct Mol Biol 15:1246-54. 2008
  8. pmc Deubiquitylation of histone H2A activates transcriptional initiation via trans-histone cross-talk with H3K4 di- and trimethylation
    Takeya Nakagawa
    Nagasaki University School of Medicine, Nagasaki 852 8523, Japan
    Genes Dev 22:37-49. 2008
  9. ncbi A critical role for the ubiquitin-conjugating enzyme Ubc13 in initiating homologous recombination
    Guang Yu Zhao
    CREST Laboratory, Department of Radiation Genetics, Kyoto University Graduate School of Medicine, Yoshida Konoe, Sakyo ku, Kyoto 606 8501, Japan
    Mol Cell 25:663-75. 2007
  10. doi Absence of Ku70 gene obliterates X-ray-induced lacZ mutagenesis of small deletions in mouse tissues
    Yoshihiko Uehara
    Department of Cell Biology, Graduate School of Medicine, Tohoku University, 2 1 Seiryo machi, Aoba ku, Sendai, Japan
    Radiat Res 170:216-23. 2008

Collaborators

Detail Information

Publications12

  1. ncbi [Dynamic organization of chromatin in DNA repair]
    Tsuyoshi Ikura
    Tanpakushitsu Kakusan Koso 51:310-4. 2006
  2. ncbi [Role of histone variant in DNA metabolism]
    Tsuyoshi Ikura
    Tanpakushitsu Kakusan Koso 51:2083-5. 2006
  3. pmc DNA damage-dependent acetylation and ubiquitination of H2AX enhances chromatin dynamics
    Tsuyoshi Ikura
    Department of Biochemistry, Tohoku University Graduate School of Medicine, Seiryoumachi 2 1, Aobaku Sendai 980 8575, Japan
    Mol Cell Biol 27:7028-40. 2007
    ..We conclude that the sequential acetylation and ubiquitination of H2AX by TIP60-UBC13 promote enhanced histone dynamics, which in turn stimulate a DNA damage response...
  4. pmc A novel interplay between the Fanconi anemia core complex and ATR-ATRIP kinase during DNA cross-link repair
    Junya Tomida
    Department of Late Effects Studies, Laboratory of DNA Damage Signaling, Kyoto University, Kyoto 606 8501, Japan, Japan Society for the Promotion of Science JSPS, Tokyo 102 0083, Japan
    Nucleic Acids Res 41:6930-41. 2013
    ..Collectively, these data reveal new aspects of the interplay between regulation of ATR-ATRIP kinase and activation of the FA pathway. ..
  5. doi Bach1-mediated suppression of p53 is inhibited by p19(ARF) independently of MDM2
    Hironari Nishizawa
    Department of Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan
    Cancer Sci 103:897-903. 2012
    ..The p19(ARF)-Bach1 interaction constitutes a regulatory pathway of p53 in parallel with the p19(ARF)-MDM2 pathway...
  6. doi Methionine adenosyltransferase II serves as a transcriptional corepressor of Maf oncoprotein
    Yasutake Katoh
    Department of Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Miyagi 980 8575, Japan
    Mol Cell 41:554-66. 2011
    ..MATII serves as a transcriptional corepressor of MafK by interacting with chromatin regulators and supplying SAM for methyltransferases...
  7. ncbi Bach1 inhibits oxidative stress-induced cellular senescence by impeding p53 function on chromatin
    Yoshihiro Dohi
    Department of Biochemistry, Tohoku University Graduate School of Medicine, Seiryo machi 2 1, Sendai 980 8575, Japan
    Nat Struct Mol Biol 15:1246-54. 2008
    ..Because Bach1 is regulated by oxidative stress and heme, our data show that Bach1 connects oxygen metabolism and cellular senescence as a negative regulator of p53...
  8. pmc Deubiquitylation of histone H2A activates transcriptional initiation via trans-histone cross-talk with H3K4 di- and trimethylation
    Takeya Nakagawa
    Nagasaki University School of Medicine, Nagasaki 852 8523, Japan
    Genes Dev 22:37-49. 2008
    ..Our studies revealed a novel mode of trans-histone cross-talk, in which H2A ubiquitylation controls the di- and trimethylation of H3K4, resulting in regulation of transcriptional initiation...
  9. ncbi A critical role for the ubiquitin-conjugating enzyme Ubc13 in initiating homologous recombination
    Guang Yu Zhao
    CREST Laboratory, Department of Radiation Genetics, Kyoto University Graduate School of Medicine, Yoshida Konoe, Sakyo ku, Kyoto 606 8501, Japan
    Mol Cell 25:663-75. 2007
    ..Furthermore, generation of ssDNA/RPA complexes at DSBs is severely attenuated in the absence of Ubc13. These data reveal a critical and unexpected role for vertebrate Ubc13 in the initiation of HR at the level of DSB processing...
  10. doi Absence of Ku70 gene obliterates X-ray-induced lacZ mutagenesis of small deletions in mouse tissues
    Yoshihiko Uehara
    Department of Cell Biology, Graduate School of Medicine, Tohoku University, 2 1 Seiryo machi, Aoba ku, Sendai, Japan
    Radiat Res 170:216-23. 2008
    ..These data indicate a predominant role of non-homologous end joining in the production of radiation-induced mutations in vivo...
  11. ncbi Dynamic interaction of p220(NPAT) and CBP/p300 promotes S-phase entry
    Aiyan Wang
    Section of Molecular Craniofacial Embryology, Graduate School, Tokyo Medical and Dental University, Bunkyo ku, Tokyo 113 8549, Japan
    Biochem Biophys Res Commun 325:1509-16. 2004
    ..Overall, our findings demonstrate that p220(NPAT) and CBP/p300 form a transient complex at the G1/S boundary to play cooperative roles to promote the S-phase entry...
  12. ncbi Chromatin dynamics and DNA repair
    Tsuyoshi Ikura
    Research Institute for Radiation Biology and Medicine, Department of Experimental Oncology, Hiroshima University, Hiroshima 734 8553, Japan
    Front Biosci 8:s149-55. 2003
    ..Defects in the proper maintenance of chromatin states after repair could be a factor in the aging process, as well as in other pathologies...