Akira Horii

Summary

Affiliation: Tohoku University
Country: Japan

Publications

  1. ncbi Infrequent mutation of APC, AXIN1, and GSK3B in human pituitary adenomas with abnormal accumulation of CTNNB1
    Chunlan Sun
    Department of Molecular Pathology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    J Neurooncol 73:131-4. 2005
  2. ncbi Chromosome 12, frequently deleted in human pancreatic cancer, may encode a tumor-suppressor gene that suppresses angiogenesis
    Sumitaka Yamanaka
    Department of Molecular Pathology, Tohoku University School of Medicine, Sendai, Japan
    Lab Invest 84:1339-51. 2004
  3. ncbi Promoter hypermethylation is not the major mechanism for inactivation of the FBXW7 beta-form in human gliomas
    Zhaodi Gu
    Department of Molecular Pathology, Tohoku University School of Medicine, Sendai, Japan
    Genes Genet Syst 83:347-52. 2008
  4. ncbi RNA interference targeting against S100A4 suppresses cell growth and motility and induces apoptosis in human pancreatic cancer cells
    Takahiro Tabata
    Department of Molecular Pathology, Tohoku University School of Medicine, Sendai, Miyagi 980 8575, Japan
    Biochem Biophys Res Commun 390:475-80. 2009
  5. ncbi The PMAIP1 gene on chromosome 18 is a candidate tumor suppressor gene in human pancreatic cancer
    Masaharu Ishida
    Department of Molecular Pathology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, Japan
    Dig Dis Sci 53:2576-82. 2008
  6. ncbi Distinct progression pathways involving the dysfunction of DUSP6/MKP-3 in pancreatic intraepithelial neoplasia and intraductal papillary-mucinous neoplasms of the pancreas
    Toru Furukawa
    Department of Molecular Pathology, Tohoku University School of Medicine, Sendai, Japan
    Mod Pathol 18:1034-42. 2005
  7. ncbi siRNA targeting against EGFR, a promising candidate for a novel therapeutic application to lung adenocarcinoma
    Sumitaka Yamanaka
    Department of Molecular Pathology, Tohoku University School of Medicine, Sendai, Japan
    Pathobiology 75:2-8. 2008
  8. ncbi The methylation status of FBXW7 beta-form correlates with histological subtype in human thymoma
    Zhaodi Gu
    Department of Molecular Pathology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, Miyagi 980 8575, Japan
    Biochem Biophys Res Commun 377:685-8. 2008
  9. ncbi A cDNA microarray analysis identifies 52 genes associated with cis-diamminedichloroplatinum susceptibility in head and neck squamous cell carcinoma cell lines
    Takenori Ogawa
    Department of Molecular Pathology, Tohoku University School of Medicine, Sendai Miyagi 980 8575, Japan
    Eur Arch Otorhinolaryngol 267:123-9. 2010
  10. ncbi Methyl-CpG targeted transcriptional activation allows re-expression of tumor suppressor genes in human cancer cells
    Shinichi Fukushige
    Department of Molecular Pathology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, Miyagi 980 8575, Japan
    Biochem Biophys Res Commun 377:600-5. 2008

Detail Information

Publications67

  1. ncbi Infrequent mutation of APC, AXIN1, and GSK3B in human pituitary adenomas with abnormal accumulation of CTNNB1
    Chunlan Sun
    Department of Molecular Pathology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    J Neurooncol 73:131-4. 2005
    ..However, the possibility that mutation of regions outside of our survey or epigenetic mechanism play an important role cannot be excluded...
  2. ncbi Chromosome 12, frequently deleted in human pancreatic cancer, may encode a tumor-suppressor gene that suppresses angiogenesis
    Sumitaka Yamanaka
    Department of Molecular Pathology, Tohoku University School of Medicine, Sendai, Japan
    Lab Invest 84:1339-51. 2004
    ..In summary, this study provides the first functional evidence of the existence of an additional tumor-suppressor gene(s) on chromosome 12, whose absence is responsible for the pathogenesis in pancreatic ductal carcinogenesis...
  3. ncbi Promoter hypermethylation is not the major mechanism for inactivation of the FBXW7 beta-form in human gliomas
    Zhaodi Gu
    Department of Molecular Pathology, Tohoku University School of Medicine, Sendai, Japan
    Genes Genet Syst 83:347-52. 2008
    ....
  4. ncbi RNA interference targeting against S100A4 suppresses cell growth and motility and induces apoptosis in human pancreatic cancer cells
    Takahiro Tabata
    Department of Molecular Pathology, Tohoku University School of Medicine, Sendai, Miyagi 980 8575, Japan
    Biochem Biophys Res Commun 390:475-80. 2009
    ..Our present results suggest the possibility that the inhibition of S100A4 can be utilized in antitumor applications for patients with pancreatic cancer...
  5. ncbi The PMAIP1 gene on chromosome 18 is a candidate tumor suppressor gene in human pancreatic cancer
    Masaharu Ishida
    Department of Molecular Pathology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, Japan
    Dig Dis Sci 53:2576-82. 2008
    ..These results suggest that PMAIP1 may play an important role in the progression of pancreatic cancer...
  6. ncbi Distinct progression pathways involving the dysfunction of DUSP6/MKP-3 in pancreatic intraepithelial neoplasia and intraductal papillary-mucinous neoplasms of the pancreas
    Toru Furukawa
    Department of Molecular Pathology, Tohoku University School of Medicine, Sendai, Japan
    Mod Pathol 18:1034-42. 2005
    ....
  7. ncbi siRNA targeting against EGFR, a promising candidate for a novel therapeutic application to lung adenocarcinoma
    Sumitaka Yamanaka
    Department of Molecular Pathology, Tohoku University School of Medicine, Sendai, Japan
    Pathobiology 75:2-8. 2008
    ....
  8. ncbi The methylation status of FBXW7 beta-form correlates with histological subtype in human thymoma
    Zhaodi Gu
    Department of Molecular Pathology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, Miyagi 980 8575, Japan
    Biochem Biophys Res Commun 377:685-8. 2008
    ..014). We propose a novel mechanism for the pathogenesis of thymoma by FBXW7 beta-form and hypothesize that expressional suppression plays an important role in the malignant potential of thymoma...
  9. ncbi A cDNA microarray analysis identifies 52 genes associated with cis-diamminedichloroplatinum susceptibility in head and neck squamous cell carcinoma cell lines
    Takenori Ogawa
    Department of Molecular Pathology, Tohoku University School of Medicine, Sendai Miyagi 980 8575, Japan
    Eur Arch Otorhinolaryngol 267:123-9. 2010
    ..Our present results give us valuable clues to better understand the chemosensitivities of such cells to CDDP. This will improve the clinical management of patients with HNSCC...
  10. ncbi Methyl-CpG targeted transcriptional activation allows re-expression of tumor suppressor genes in human cancer cells
    Shinichi Fukushige
    Department of Molecular Pathology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, Miyagi 980 8575, Japan
    Biochem Biophys Res Commun 377:600-5. 2008
    ..Our present results lead to an efficient way to search for transcriptionally silenced genes with highly methylated CpG islands, particularly TSGs in cancer and developmentally important genes in embryonic stem cells...
  11. ncbi Inserting chromosome 18 into pancreatic cancer cells switches them to a dormant metastatic phenotype
    Liviu P Lefter
    Department of Molecular Pathology, Tohoku University School of Medicine, Sendai 980-8575, Japan
    Clin Cancer Res 9:5044-52. 2003
    ..These data represent the first functional evidence suggesting that chromosome 18q encodes a gene that strongly suppresses metastatic activity, possibly through dormancy...
  12. ncbi DSCP1, a novel TP53-inducible gene, is upregulated by strong genotoxic stresses and its overexpression inhibits tumor cell growth in vitro
    Tatsuo Hata
    Department of Molecular Pathology, Tohoku University School of Medicine, Sendai, Miyagi, Japan
    Int J Oncol 24:513-20. 2004
    ..These results indicate that DSCP1 is a stress-inducible gene in both a TP53 dependent and independent manner and that its protein product can inhibit cancer cell growth...
  13. ncbi The thymine DNA glycosylase MBD4 represses transcription and is associated with methylated p16(INK4a) and hMLH1 genes
    Emiko Kondo
    Department of Molecular Pathology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, Miyagi 980 8575, Japan
    Mol Cell Biol 25:4388-96. 2005
    ..These results suggest that MBD4 is one of the essential components involved in epigenetic silencing in cancer and its repair activity is necessary for the maintenance of hypermethylated promoters...
  14. ncbi RET finger protein enhances MBD2- and MBD4-dependent transcriptional repression
    Shinichi Fukushige
    Department of Molecular Pathology, Tohoku University School of Medicine, Sendai, Miyagi 980 8575, Japan
    Biochem Biophys Res Commun 351:85-92. 2006
    ....
  15. ncbi Methyl-CpG targeted recruitment of p300 reactivates tumor suppressor genes in human cancer cells
    Shinichi Fukushige
    Department of Molecular Pathology, Tohoku University School of Medicine, Sendai, Miyagi 980 8575, Japan
    Biochem Biophys Res Commun 379:1021-6. 2009
    ..These results demonstrate that it is possible to reactivate epigenetically silenced TSGs in human cancer cells by direct targeting of a transcriptional coactivator at highly methylated promoters...
  16. ncbi miR-34a is downregulated in cis-diamminedichloroplatinum treated sinonasal squamous cell carcinoma patients with poor prognosis
    Takenori Ogawa
    Department of Molecular Pathology, Tohoku University School of Medicine, Miyagi, Japan
    Cancer Sci 103:1737-43. 2012
    ..These results strongly suggest that miR-34a expression can be an independent prognostic biomarker in patients with sinonasal squamous cell carcinoma who are undergoing treatment with cis-diamminedichloroplatinum...
  17. ncbi Upregulation of IGF2 is associated with an acquired resistance for cis-diamminedichloroplatinum in human head and neck squamous cell carcinoma
    Takenori Ogawa
    Department of Molecular Pathology, Tohoku University School of Medicine, Sendai, Miyagi, 980 8575, Japan
    Eur Arch Otorhinolaryngol 267:1599-606. 2010
    ..These findings suggest the possibility for developing a new strategy for treating patients with HNSCC, particularly those with acquired CDDP resistance, by combining CDDP with inhibition of the IGF2 pathway...
  18. ncbi The role of chromosome 18 abnormalities in the progression of pancreatic adenocarcinoma
    Makoto Sunamura
    Department of Gastroenterological Surgery, Tohoku University School of Medicine, Sendai, Japan
    Pancreas 28:311-6. 2004
    ..It was revealed that there was increased expression of 4 genes relating to apoptosis in the 18 chromosome hybrids cells compared with the parental cells. We are now analyzing the function of these genes...
  19. ncbi Identification of epigenetically silenced genes in human pancreatic cancer by a novel method "microarray coupled with methyl-CpG targeted transcriptional activation" (MeTA-array)
    Hideyuki Shimizu
    Department of Molecular Pathology, Tohoku University School of Medicine, Sendai, Miyagi 980 8575, Japan
    Biochem Biophys Res Commun 411:162-7. 2011
    ..These results suggest that MeTA-array is a highly efficient method for identifying methylation-mediated transcriptionally silenced genes in human pancreatic cancer and that this method can be applied to other types of human cancer...
  20. ncbi Abrogation of DUSP6 by hypermethylation in human pancreatic cancer
    Shanhai Xu
    Department of Molecular Pathology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    J Hum Genet 50:159-67. 2005
    ..Our combined results suggest that hypermethylation with modification of histone deacetylation play an important role in transcriptional suppression of DUSP6 in human pancreatic cancer...
  21. ncbi RNA interference targeting aurora kinase a suppresses tumor growth and enhances the taxane chemosensitivity in human pancreatic cancer cells
    Tatsuo Hata
    Department of Molecular Pathology, Tohoku University School of Medicine, Sendai Miyagi, Japan
    Cancer Res 65:2899-905. 2005
    ..These results indicate that inhibition of AURKA expression can result in potent antitumor activity and chemosensitizing activity to taxanes in human pancreatic cancer...
  22. ncbi TU12B1-TY, a novel gene in the region at 12q22-q23.1 frequently deleted in pancreatic cancer, shows reduced expression in pancreatic cancer cells
    Toshimasa Yatsuoka
    Department of Molecular Pathology, Tohoku University School of Medicine, Miyagi 980 8575, Japan
    Oncol Rep 12:1263-8. 2004
    ..The present results indicate that reduced function of TU12B1-TY may contribute to the development and/or progression of human pancreatic cancer...
  23. ncbi Exploration of genetic alterations in human endometrial cancer and melanoma: distinct tumorigenic pathways that share a frequent abnormal PI3K/AKT cascade
    Kazumi Ogawa
    Department of Molecular Pathology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Oncol Rep 14:1481-5. 2005
    ....
  24. ncbi Comparative genomic hybridization and mutation analyses of sporadic schwannomas
    Takayuki Ikeda
    Department of Molecular Pathology, Tohoku University School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, 980-8575, Japan
    J Neurooncol 72:225-30. 2005
    ....
  25. ncbi Elucidation of the relationship of BNIP3 expression to gemcitabine chemosensitivity and prognosis
    Masaharu Ishida
    Department of Molecular Pathology, Tohoku University School of Medicine, 2 1 Seiryo machi, Sendai, Japan
    World J Gastroenterol 13:4593-7. 2007
    ....
  26. ncbi Cell surface glyceraldehyde-3-phosphate dehydrogenase (GAPDH) of Lactobacillus plantarum LA 318 recognizes human A and B blood group antigens
    Hideki Kinoshita
    Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Tsutsumidori Amamiyamachi 1 1, Aoba ku, Sendai, Miyagi 981 8555, Japan
    Res Microbiol 159:685-91. 2008
    ..The binding of GAPDH to HCM significantly decreased after incubation with NAD+. This suggests that the NAD binding domain on GAPDH may be related to binding to HCM...
  27. ncbi [Mechanistic insights for pancreatic carcinogenesis]
    Toru Furukawa
    Department of Molecular Pathology, Tohoku University School of Medicine
    Nippon Rinsho 64:27-31. 2006
  28. ncbi Infrequent somatic mutations of the ICAT gene in various human cancers with frequent 1p-LOH and/or abnormal nuclear accumulation of beta-catenin
    Mitsuho Imai
    Department of Molecular Pathology, Tohoku University School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan
    Oncol Rep 12:1099-103. 2004
    ....
  29. ncbi Computed tomographic images reflect the biologic behavior of small lung adenocarcinoma: they correlate with cell proliferation, microvascularization, cell adhesion, degradation of extracellular matrix, and K-ras mutation
    Boming Dong
    Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University School of Medicine, Sendai, Japan
    J Thorac Cardiovasc Surg 130:733-9. 2005
    ..CONCLUSIONS: Our results suggest that the computed tomographic image of small lung adenocarcinoma is correlated with biologic activities and thus provides possible prognostic information...
  30. ncbi siRNA-mediated knockdown against CDCA1 and KNTC2, both frequently overexpressed in colorectal and gastric cancers, suppresses cell proliferation and induces apoptosis
    Naoyuki Kaneko
    Department of Molecular Pathology, Tohoku University School of Medicine, Sendai, Miyagi 980 8575, Japan
    Biochem Biophys Res Commun 390:1235-40. 2009
    ..Our present results suggest that expressional control of component molecules of Ndc80 can be utilized for molecular target therapy of patients with CRC and GC...
  31. ncbi DCK is frequently inactivated in acquired gemcitabine-resistant human cancer cells
    Yuriko Saiki
    Department of Molecular Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Biochem Biophys Res Commun 421:98-104. 2012
    ..We found inactivating mutations in RDLD-1 and RTFK-1 and decreased expression of DCK in RMKN-28. These results indicate that the inactivation of DCK is one of the crucial mechanisms in acquisition of gemcitabine resistance...
  32. ncbi Potential tumor suppressive pathway involving DUSP6/MKP-3 in pancreatic cancer
    Toru Furukawa
    Department of Molecular Pathology, Tohoku University School of Medicine, Sendai, Japan
    Am J Pathol 162:1807-15. 2003
    ..These results show that DUSP6 exerts apparent tumor-suppressive effects in vitro and suggest that DUSP6 is a strong candidate tumor suppressor gene at 12q22 locus...
  33. ncbi The FBXW7 beta-form is suppressed in human glioma cells
    Zhaodi Gu
    Department of Molecular Pathology, Tohoku University School of Medicine, 2 1 Seiryo machi, Sendai, Japan
    Biochem Biophys Res Commun 354:992-8. 2007
    ..Our present results imply that FBXW7 plays a pivotal role in many tissues by controlling the amount of cell cycle promoter proteins and that dysfunction of this protein is one of the essential steps in carcinogenesis in multiple organs...
  34. ncbi S100A4, frequently overexpressed in various human cancers, accelerates cell motility in pancreatic cancer cells
    Hitoshi Sekine
    Department of Molecular Pathology, Tohoku University School of Medicine, Sendai, Miyagi 980 8575, Japan
    Biochem Biophys Res Commun 429:214-9. 2012
    ..Our results suggest that S100A4 is crucial for cell motility in pancreatic cancer and that some downstream genes may play important roles in cell motility...
  35. ncbi Synchronous and metachronous extrapancreatic malignant neoplasms in patients with intraductal papillary-mucinous neoplasm of the pancreas
    Masaharu Ishida
    Department of Gastroenterological Surgery, Tohoku University Graduate School of Medicine, Aoba ku, Sendai, Japan
    Pancreatology 8:577-82. 2008
    ..Recently there have been some reports on extrapancreatic malignant neoplasms (EPM) occurring in patients with IPMN. The purpose of this study was to discover the characteristic features of IPMN with EPM compared with IPMN without EPM...
  36. ncbi Molecular pathology of pancreatic cancer: in quest of tumor suppressor genes
    Toru Furukawa
    Department of Molecular Pathology, Tohoku University School of Medicine, Sendai, Miyagi, Japan
    Pancreas 28:253-6. 2004
    ..We continue work to more completely understand the complex molecular mechanisms of pancreatic carcinogenesis and to apply the information gained to the clinical treatment of pancreatic cancer...
  37. ncbi A novel G106D alteration of the SDHD gene in a pedigree with familial paraganglioma
    Kazumi Ogawa
    Department of Molecular Pathology, Tohoku University School of Medicine, Sendai, Japan
    Am J Med Genet A 140:2441-6. 2006
    ..Our results may lead to a better understanding of this disease and to the development of methods for prevention of this disease...
  38. ncbi APAF-1-ALT, a novel alternative splicing form of APAF-1, potentially causes impeded ability of undergoing DNA damage-induced apoptosis in the LNCaP human prostate cancer cell line
    Takenori Ogawa
    Department of Molecular Pathology, Tohoku University School of Medicine, Sendai, Miyagi 980 8575, Japan
    Biochem Biophys Res Commun 306:537-43. 2003
    ..These results indicate that APAF-1-ALT is a molecule that is deficient and impeded for mediating apoptosis and that it may contribute to the resistance to DNA damage-induced treatment observed in LNCaP...
  39. ncbi Molecular mechanisms of pancreatic carcinogenesis
    Toru Furukawa
    Department of Molecular Pathology, Tohoku University School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan
    Cancer Sci 97:1-7. 2006
    ..Understanding the molecular mechanisms of pancreatic carcinogenesis will likely provide novel clues for preventing, detecting, and ultimately curing this life-threatening disease...
  40. ncbi [Genetic diagnosis of human pancreatic cancer]
    Akira Horii
    Department of Molecular Pathology, Tohoku University School of Medicine
    Nippon Shokakibyo Gakkai Zasshi 100:292-7. 2003
  41. ncbi A Human Head and Neck Squamous Cell Carcinoma Cell Line with Acquired cis-Diamminedichloroplatinum-Resistance Shows Remarkable Upregulation of BRCA1 and Hypersensitivity to Taxane
    Yuriko Saiki
    Department of Molecular Pathology, Tohoku University School of Medicine, Sendai, Miyagi 980 8575, Japan
    Int J Otolaryngol 2011:521852. 2011
    ....
  42. ncbi Microarray coupled with methyl-CpG targeted transcriptional activation (MeTA-array) identifies hypermethylated genes containing the stringent criteria of CpG islands at high frequency
    Yuko Sato
    Department of Molecular Pathology, Tohoku University School of Medicine, Sendai, Miyagi, Japan
    Epigenetics 6:752-9. 2011
    ..These results suggest that microarray coupled with MeTA (MeTA-array) is an efficient alternative way to identify transcriptionally silenced genes by DNA hypermethylation...
  43. ncbi Lactic acid bacteria (LAB) bind to human B- or H-antigens expressed on intestinal mucosa
    Hideaki Uchida
    Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University
    Biosci Biotechnol Biochem 70:3073-6. 2006
    ..We found two strains, L. gasseri OLL2755 and L. gasseri OLL2877 that firmly adhere to human B-antigen, and we found L. gasseri OLL2827 bound to the H-antigen...
  44. ncbi Classification of types of intraductal papillary-mucinous neoplasm of the pancreas: a consensus study
    Toru Furukawa
    Department of Molecular Pathology, Tohoku University School of Medicine, 2 1 Seiryomachi, Sendai, 980 8575, Japan
    Virchows Arch 447:794-9. 2005
    ..These definitions can be used for further analyses of the clinicopathological significance of the variations of IPMN...
  45. ncbi BRAF point mutations in primary melanoma show different prevalences by subtype
    Yoshinori Sasaki
    Department of Molecular Pathology, Tohoku University School of Medicine, Sendai, Japan
    J Invest Dermatol 123:177-83. 2004
    ..The BRAF mutation was observed frequently even in small lesions, indicating that activation of this gene may be one of the early events in the pathogenesis of some melanomas...
  46. ncbi Loss of heterozygosity analyses of asynchronous lesions of ductal carcinoma in situ and invasive ductal carcinoma of the human breast
    Masakazu Amari
    Division of Surgical Oncology, Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    Jpn J Clin Oncol 33:556-62. 2003
    ....
  47. ncbi A yeast two-hybrid assay provides a simple way to evaluate the vast majority of hMLH1 germ-line mutations
    Emiko Kondo
    Department of Molecular Pathology, Tohoku University School of Medicine, Miyagi 980 8575, Japan
    Cancer Res 63:3302-8. 2003
    ..Thus, this method provides a simple and reliable system for accurate diagnosis of hMLH1 alterations...
  48. ncbi Suppression of the tumorigenic phenotype by chromosome 18 transfer into pancreatic cancer cell lines
    Liviu P Lefter
    Department of Molecular Pathology, Tohoku University School of Medicine, Sendai, Japan
    Genes Chromosomes Cancer 34:234-42. 2002
    ....
  49. ncbi Lactobacilli binding human A-antigen expressed in intestinal mucosa
    Hideaki Uchida
    Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Tsutsumidori Amamiyamachi 1 1, Aoba ku, Sendai 981 8555, Miyagi, Japan
    Res Microbiol 157:659-65. 2006
    ..brevis ATCC8287T. The probiotic LAB binds to human blood type-A antigen expressed in the intestinal mucosa which may aid in colonization of the gut...
  50. ncbi Gene therapy for pancreatic cancer targeting the genomic alterations of tumor suppressor genes using replication-selective oncolytic adenovirus
    Makoto Sunamura
    Division of Gastroenterological Surgery, Tohoku University, Graduate School of Medicine, Sendai, Japan
    Hum Cell 15:138-50. 2002
    ..These results revealed thatthe AxE1AdB-UPRT/5FU system is a promising tool for intraperitoneal disseminated pancreatic cancer...
  51. ncbi Restoration of SMAD4 by gene therapy reverses the invasive phenotype in pancreatic adenocarcinoma cells
    Dan G Duda
    Division of Gastroenterological Surgery, Graduate School of Medicine, Tohoku University, 980-8574 Sendai, Japan
    Oncogene 22:6857-64. 2003
    ..ETS-1 is considered a marker for tumour invasion. Upon SMAD4 deletion, we detected high expression levels of ETS-1 in pancreatic tumour cells, suggesting the shift of the pancreatic tumour toward an invasive phenotype...
  52. ncbi Functional analysis of chromosome 18 in pancreatic cancer: strong evidence for new tumour suppressor genes
    Liviu P Lefter
    Departments of Gastrointestinal Surgery and Molecular Pathology, Tohoku University Graduate School of Medicine, 1-1 Seiryomachi, Aoba-ku, Sendai 980-8574, Japan
    Asian J Surg 27:85-92. 2004
    ..CONCLUSION: These data represent strong functional evidence that chromosome 18q encodes strong tumour and metastasis suppressor activity that is able to switch human pancreatic cancer cells to a dormant phenotype...
  53. ncbi A new assay using surface plasmon resonance (SPR) to determine binding of the Lactobacillus acidophilus group to human colonic mucin
    Hideaki Uchida
    Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan
    Biosci Biotechnol Biochem 68:1004-10. 2004
    ..The results indicated that some strains of the L. acidophilus group could recognize and bind the sugar chain of A-antigen structure on HCM...
  54. ncbi Impairment of double-strand breaks repair and aberrant splicing of ATM and MRE11 in leukemia-lymphoma cell lines with microsatellite instability
    Maria Francisca Ham
    Department of Pathology, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita-shi, Osaka 565-0871, Japan
    Cancer Sci 97:226-34. 2006
    ..This might result in inactivation of the DSB repair system, thus inducing an acceleration of genome instability and accumulation of genetic damage...
  55. ncbi Elevated expression of mitogen-activated protein kinase phosphatase 3 in breast tumors: a mechanism of tamoxifen resistance
    Yukun Cui
    Breast Center and Department of Medicine, Baylor College of Medicine, Houston, Texas, USA
    Cancer Res 66:5950-9. 2006
    ..MKP3 represents a novel mechanism of resistance, which may be a potential biomarker for the use of ERK1/2 and/or JNK inhibitors in combination with tamoxifen treatment...
  56. ncbi Immune responses to DNA mismatch repair enzymes hMSH2 and hPMS1 in patients with pancreatic cancer, dermatomyositis and polymyositis
    Takaho Okada
    Division of Cellular Signaling, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan
    Int J Cancer 116:925-33. 2005
    ....
  57. ncbi Characteristic clinicopathological features of the types of intraductal papillary-mucinous neoplasms of the pancreas
    Masaharu Ishida
    Department of Gastroenterological Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan
    Pancreas 35:348-52. 2007
    ..The purpose of this study was to determine associations between the histological types and clinicopathological features in patients with IPMN...
  58. ncbi Screening for functional tumor suppressor activity in pancreatic cancer
    Liviu Lefter
    3rd Department of Surgery, St Spiridon University Hospital, Iasi, Romania
    Rom J Gastroenterol 13:195-201. 2004
    ..The functional data emerging from this study bring into sharp relief the implication of chromosome 18 as a putative location for new TSG(s), yet to be identified in this region...
  59. ncbi Identification of SMURF1 as a possible target for 7q21.3-22.1 amplification detected in a pancreatic cancer cell line by in-house array-based comparative genomic hybridization
    Ayako Suzuki
    Department of Molecular Cytogenetics, Medical Research Institute and School of Biomedical Science, Tokyo Medical and Dental University, 1 5 45 Yushima Bunkyo ku, Tokyo, Japan
    Cancer Sci 99:986-94. 2008
    ....
  60. ncbi Mutations in the serine protease inhibitor Kazal Type 1 (SPINK1) gene in Japanese patients with pancreatitis
    Kiyoshi Kume
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Pancreatology 5:354-60. 2005
    ..We here examined the prevalence of SPINK1 mutations in Japanese patients with pancreatitis...
  61. ncbi Microarray analysis of promoter methylation in lung cancers
    Masayuki Fukasawa
    Laboratory of Genome Science, Biosignal Genome Resource Center, Department of Molecular and Cellular Biology, Gunma University, 3-39-15 Showa-machi, Maebashi 371-8512, Japan
    J Hum Genet 51:368-74. 2006
    ..This demonstrates that our PMAD method is effective at finding epigenetic changes during cancer...
  62. ncbi A novel target gene, SKP2, within the 5p13 amplicon that is frequently detected in small cell lung cancers
    Sana Yokoi
    Department of Molecular Cytogenetics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    Am J Pathol 161:207-16. 2002
    ..Our results indicate that SKP2 is likely to be a target of the 5p13 amplification and to play an important role in the growth of SCLC cells...
  63. ncbi The mammalian homolog of the Drosophila discs large tumor suppressor protein up-regulates expression of the ELR+ CXC chemokine Scyb5
    Tomoiki Aiba
    Laboratory of Molecular and Genetic Information, Institute for Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan
    Biochem Biophys Res Commun 337:191-4. 2005
    ..Our finding suggests that Scyb5 may play an important role in the tumor suppressor function of Dlg...
  64. ncbi A microarray-based method for detecting methylated loci
    Izuho Hatada
    Gene Research Center, Gunma University, 3 39 22 Showa machi, Maebashi 371 8511, Japan
    J Hum Genet 47:448-51. 2002
    ..Choosing the methylated DNA library as the resource material of the microarray increased the percentage of DNA fragments derived from hypermethylated loci on the microarray...
  65. ncbi Loss of heterozygosity on chromosome 16p and 18q in anaplastic thyroid carcinoma
    Masao Kadota
    Department of Surgery and Clinical Oncology, Osaka University Graduate School of Medicine, Japan
    Oncol Rep 10:35-8. 2003
    ..D16S423, D16S418 and D16s406 on 16p13.3 were the most frequently deleted loci in anaplastic cancers, and the region around these may harbor the putative tumor suppressor gene related to anaplastic transformation of thyroid cancer...
  66. ncbi Orthotopic implantation mouse model and cDNA microarray analysis indicates several genes potentially involved in lymph node metastasis of colorectal cancer
    Hiroyuki Sasaki
    Division of Biological Regulation and Oncology, Tohoku University Graduate School of Medicine, Miyagi 980 8574, Japan
    Cancer Sci 99:711-9. 2008
    ..In conclusion, the orthotopic implantation mice model with Matrigel was useful, and we isolated candidate genes such as RNF125 that possibly play an important role in LN metastasis of CRC cells...
  67. ncbi In vivo induction of necrosis in mice fibrosarcoma via intravenous injection of type B staphylococcal enterotoxin
    Abbas Ali Imani Fooladi
    Research Center of Molecular Biology and Department of Microbiology, Baqiyatallah University of Medical Sciences, Tehran, Iran
    Biotechnol Lett 30:2053-9. 2008
    ....