Hiroki Hayashi

Summary

Affiliation: Tohoku University
Country: Japan

Publications

  1. doi request reprint Safety of postoperative thromboprophylaxis after major hepatobiliary-pancreatic surgery in Japanese patients
    Hiroki Hayashi
    Division of Hepato Biliary Pancreatic Surgery, Department of Surgery, Tohoku University Hospital, 1 1, Seiryo machi, Aoba ku, Sendai, 980 8574, Japan
    Surg Today 44:1660-8. 2014
  2. ncbi request reprint A highly effective and stable bispecific diabody for cancer immunotherapy: cure of xenografted tumors by bispecific diabody and T-LAK cells
    Hiroki Hayashi
    Division of Gastroenterological Surgery, Department of Surgery, Graduate School of Medicine, Tohoku University, Seiryomachi 1 1, Aoba ku, 980 8574 Sendai, Japan
    Cancer Immunol Immunother 53:497-509. 2004
  3. pmc Potential utility of eGFP-expressing NOG mice (NOG-EGFP) as a high purity cancer sampling system
    Kentaro Shima
    Division of Hepato Biliary Pancreatic Surgery, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi aoba ku, Sendai, 980 8574, Japan
    J Exp Clin Cancer Res 31:55. 2012
  4. doi request reprint Diabody-based recombinant formats of humanized IgG-like bispecific antibody with effective retargeting of lymphocytes to tumor cells
    Ryutaro Asano
    Department of Biomolecular Engineering, Graduate School of Engineering, Institute of Development, Aging, and Cancer, Tohoku University, Sendai, Japan
    J Immunother 31:752-61. 2008
  5. doi request reprint Application of the Fc fusion format to generate tag-free bi-specific diabodies
    Ryutaro Asano
    Department of Biomolecular Engineering, Graduate School of Engineering, Tohoku University, Sendai, Japan
    FEBS J 277:477-87. 2010
  6. doi request reprint Major hepatectomy for perihilar cholangiocarcinoma
    Michiaki Unno
    Division of Hepato Biliary Pancreatic Surgery, Department of Surgery, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    J Hepatobiliary Pancreat Sci 17:463-9. 2010
  7. doi request reprint Lymph nodes metastasis is a risk factor for bone metastasis from extrahepatic cholangiocarcinoma
    Yu Katayose
    Integrated Surgery and Oncology, Tohoku Unversity Graduate School of Medicine, Sendai, Japan
    Hepatogastroenterology 59:1758-60. 2012
  8. doi request reprint Construction and humanization of a functional bispecific EGFR × CD16 diabody using a refolding system
    Ryutaro Asano
    Department of Biomolecular Engineering, Graduate School of Engineering, Tohoku University, Sendai, Japan
    FEBS J 279:223-33. 2012
  9. doi request reprint In vitro and in vivo antitumor effects of recombinant bispecific antibodies based on humanized anti-EGFR antibody
    Yasuhiro Watanabe
    Division of Gastroenterological Surgery, Department of Surgery, Graduate School of Medicine, Tohoku University, Sendai 980 8574, Japan
    Oncol Rep 26:949-55. 2011
  10. doi request reprint Computed tomography reflected endocrine function of the pancreas
    Naoaki Sakata
    Division of Hepato Biliary Pancreatic Surgery, Department of Surgery, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai, Miyagi 980 8574, Japan
    J Gastrointest Surg 15:525-32. 2011

Collaborators

Detail Information

Publications19

  1. doi request reprint Safety of postoperative thromboprophylaxis after major hepatobiliary-pancreatic surgery in Japanese patients
    Hiroki Hayashi
    Division of Hepato Biliary Pancreatic Surgery, Department of Surgery, Tohoku University Hospital, 1 1, Seiryo machi, Aoba ku, Sendai, 980 8574, Japan
    Surg Today 44:1660-8. 2014
    ..We conducted this study to evaluate the safety of thromboprophylaxis after major hepatobiliary-pancreatic surgery...
  2. ncbi request reprint A highly effective and stable bispecific diabody for cancer immunotherapy: cure of xenografted tumors by bispecific diabody and T-LAK cells
    Hiroki Hayashi
    Division of Gastroenterological Surgery, Department of Surgery, Graduate School of Medicine, Tohoku University, Seiryomachi 1 1, Aoba ku, 980 8574 Sendai, Japan
    Cancer Immunol Immunother 53:497-509. 2004
    ..Recent advances in genetic engineering have made it possible to prepare immunoglobulin fragments consisting of variable domains using bacterial expression systems...
  3. pmc Potential utility of eGFP-expressing NOG mice (NOG-EGFP) as a high purity cancer sampling system
    Kentaro Shima
    Division of Hepato Biliary Pancreatic Surgery, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi aoba ku, Sendai, 980 8574, Japan
    J Exp Clin Cancer Res 31:55. 2012
    ..We hypothesized that xenograft models of NOG mice expressing enhanced green fluorescent protein (eGFP), referred to as NOG-EGFP mice, may be useful for obtaining such high purity cancer cells for detailed molecular and cellular analyses...
  4. doi request reprint Diabody-based recombinant formats of humanized IgG-like bispecific antibody with effective retargeting of lymphocytes to tumor cells
    Ryutaro Asano
    Department of Biomolecular Engineering, Graduate School of Engineering, Institute of Development, Aging, and Cancer, Tohoku University, Sendai, Japan
    J Immunother 31:752-61. 2008
    ....
  5. doi request reprint Application of the Fc fusion format to generate tag-free bi-specific diabodies
    Ryutaro Asano
    Department of Biomolecular Engineering, Graduate School of Engineering, Tohoku University, Sendai, Japan
    FEBS J 277:477-87. 2010
    ..This approach may be used for industrial-scale production of functional tag-free small therapeutic antibodies...
  6. doi request reprint Major hepatectomy for perihilar cholangiocarcinoma
    Michiaki Unno
    Division of Hepato Biliary Pancreatic Surgery, Department of Surgery, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    J Hepatobiliary Pancreat Sci 17:463-9. 2010
    ..The aim of this study was to review the outcomes of major hepatectomy for perihilar cholangiocarcinoma...
  7. doi request reprint Lymph nodes metastasis is a risk factor for bone metastasis from extrahepatic cholangiocarcinoma
    Yu Katayose
    Integrated Surgery and Oncology, Tohoku Unversity Graduate School of Medicine, Sendai, Japan
    Hepatogastroenterology 59:1758-60. 2012
    ..Therefore, we intend to make a comparative review of the background to bone metastasis, examine a high-risk group for bone metastasis and use the data towards the improvement in quality of life...
  8. doi request reprint Construction and humanization of a functional bispecific EGFR × CD16 diabody using a refolding system
    Ryutaro Asano
    Department of Biomolecular Engineering, Graduate School of Engineering, Tohoku University, Sendai, Japan
    FEBS J 279:223-33. 2012
    ..Our refolding system could aid in the efficient optimization of other proteins with heterodimeric structure...
  9. doi request reprint In vitro and in vivo antitumor effects of recombinant bispecific antibodies based on humanized anti-EGFR antibody
    Yasuhiro Watanabe
    Division of Gastroenterological Surgery, Department of Surgery, Graduate School of Medicine, Tohoku University, Sendai 980 8574, Japan
    Oncol Rep 26:949-55. 2011
    ..With an in vivo effect comparable to hEx3-scFv-Fc and its realistic molecular weight, hEx3-scDb-Fc shows promise as a novel recombinant therapeutic antibody and may be modified to enhance its potency by prevention of steric hindrance...
  10. doi request reprint Computed tomography reflected endocrine function of the pancreas
    Naoaki Sakata
    Division of Hepato Biliary Pancreatic Surgery, Department of Surgery, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai, Miyagi 980 8574, Japan
    J Gastrointest Surg 15:525-32. 2011
    ..In this study, we examined the correlation between CT volumetry and endocrine parameters (blood glucose and HbA1c) of the pancreas...
  11. ncbi request reprint Clock gene mouse period2 overexpression inhibits growth of human pancreatic cancer cells and has synergistic effect with cisplatin
    Akira Oda
    Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Miyagi, 980 8574, Japan
    Anticancer Res 29:1201-9. 2009
    ....
  12. ncbi request reprint Humanization of the bispecific epidermal growth factor receptor x CD3 diabody and its efficacy as a potential clinical reagent
    Ryutaro Asano
    Department of Biomolecular Engineering, Graduate School of Engineering, Tohoku University, Sendai, Japan
    Clin Cancer Res 12:4036-42. 2006
    ..For development of BsAbs as clinical reagents, we have focused on construction of small recombinant BsAbs, called bispecific diabodies. Here, we constructed and characterized a humanized bispecific diabody...
  13. doi request reprint Phase I trial of neoadjuvant chemoradiation with gemcitabine and surgical resection for cholangiocarcinoma patients (NACRAC study)
    Yu Katayose
    Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan
    Hepatogastroenterology 58:1866-72. 2011
    ....
  14. ncbi request reprint [Efficacy of neoadjuvant chemotherapy for resectable pancreatic carcinoma]
    Fuyuhiko Motoi
    Division of Hepato Biliary Pancreatic Surgery, Tohoku University Hospital
    Gan To Kagaku Ryoho 40:1632-6. 2013
    ..A prospective randomized study, Prep-02/JSAP-05, which compares neoadjuvant therapy to the surgery-first approach, is ongoing (UMIN-No. 000009634). ..
  15. doi request reprint Domain order of a bispecific diabody dramatically enhances its antitumor activity beyond structural format conversion: the case of the hEx3 diabody
    Ryutaro Asano
    Department of Biomolecular Engineering, Graduate School of Engineering, Tohoku University, Aoba 6 6 11, Aramaki, Aoba ku, Sendai 980 8579, Japan
    Protein Eng Des Sel 26:359-67. 2013
    ..Our results show that merely rearranging the domain order of BsDbs can enhance their effects beyond those with structural format conversion...
  16. doi request reprint Advanced bile duct carcinoma in a 15-year-old patient with pancreaticobiliary maljunction and congenital biliary cystic disease
    Hiroyuki Nakamura
    Division of Hepato Biliary Pancreatic Surgery, Department of Surgery, Tohoku University Graduate School of Medicine, 1 1 Seiryo cho, Aoba ku, Sendai, Japan
    J Hepatobiliary Pancreat Surg 15:554-9. 2008
    ..We should pay attention to the possibility of biliary malignancy in patients with pancreaticobiliary maljunction and congenital biliary cystic disease, even when the patients are juveniles...
  17. doi request reprint The expression of S100A4 in human pancreatic cancer is associated with invasion
    Nobukazu Tsukamoto
    Department of Pathology, Tohoku University School of Medicine, Aoba ku, Sendai, Japan
    Pancreas 42:1027-33. 2013
    ..Expression of S100A4 has been reported to correlate with poor prognosis in various cancers. We have investigated the role of S100A4 in pancreatic cancer tumorigenesis and its clinicopathologic significance...
  18. doi request reprint Assessment of Frey procedures: Japanese experience
    Shinichi Egawa
    Division of Hepato Biliary Pancreatic Surgery, Tohoku University Graduate School of Medicine, Seiryo Aoba, Sendai, 980 8574, Japan
    J Hepatobiliary Pancreat Sci 17:745-51. 2010
    ..During long-term follow up, unexpected relapse in the pancreatic tail was encountered. The pattern of failure and the rationale for a new procedure to treat or prevent such relapse were investigated...
  19. ncbi request reprint A novel adenovirus expressing human 4-1BB ligand enhances antitumor immunity
    Hiroshi Yoshida
    Department of Surgery, Division of Gastroenterological Surgery, Tohoku University Graduate School of Medicine, Japan
    Cancer Immunol Immunother 52:97-106. 2003
    ..These results provide strong evidence in support of the efficacy of adenovirally delivered 4-1BBL for genetic immunotherapy of cancer...