Takafumi Hasegawa

Summary

Affiliation: Tohoku University
Country: Japan

Publications

  1. pmc The AAA-ATPase VPS4 regulates extracellular secretion and lysosomal targeting of α-synuclein
    Takafumi Hasegawa
    Division of Neurology, Department of Neuroscience and Sensory Organs, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
    PLoS ONE 6:e29460. 2011
  2. doi request reprint Severe olfactory dysfunction is a prodromal symptom of dementia associated with Parkinson's disease: a 3 year longitudinal study
    Toru Baba
    Department of Neurology, Tohoku University Graduate School of Medicine, Sendai 980 8574, Japan
    Brain 135:161-9. 2012
  3. doi request reprint Role of TPPP/p25 on α-synuclein-mediated oligodendroglial degeneration and the protective effect of SIRT2 inhibition in a cellular model of multiple system atrophy
    Takafumi Hasegawa
    Department of Neurology, Tohoku University School of Medicine, 1 1, Seiryomachi, Aobaku, Sendai, Miyagi 980 8574, Japan
    Neurochem Int 57:857-66. 2010
  4. ncbi request reprint Role of Neu4L sialidase and its substrate ganglioside GD3 in neuronal apoptosis induced by catechol metabolites
    Takafumi Hasegawa
    Department of Neurology, Tohoku University School of Medicine, Sendai, Miyagi 980 8574, Japan
    FEBS Lett 581:406-12. 2007
  5. ncbi request reprint Alpha-synuclein facilitates the toxicity of oxidized catechol metabolites: implications for selective neurodegeneration in Parkinson's disease
    Takafumi Hasegawa
    Department of Neurology, Tohoku University School of Medicine, 1 1 Seiryomachi, Aobaku, Sendai, Miyagi 980 8574, Japan
    FEBS Lett 580:2147-52. 2006
  6. ncbi request reprint [Cellular pathophysiology of Parkinson's disease]
    Atsushi Takeda
    Division of Neurology, Department of Neuroscience and Sensory Organs, Tohoku University, Graduate School of Medicine
    Rinsho Shinkeigaku 48:984-5. 2008
  7. doi request reprint Association of olfactory dysfunction and brain. Metabolism in Parkinson's disease
    Toru Baba
    Department of Neurology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Mov Disord 26:621-8. 2011
  8. pmc Suppression of dynamin GTPase decreases α-synuclein uptake by neuronal and oligodendroglial cells: a potent therapeutic target for synucleinopathy
    Masatoshi Konno
    Division of Neurology, Department of Neuroscience and Sensory Organs, Tohoku University Graduate School of Medicine, Sendai, Miyagi 980 8574, Japan
    Mol Neurodegener 7:38. 2012
  9. ncbi request reprint Serine 129 phosphorylation of alpha-synuclein induces unfolded protein response-mediated cell death
    Naoto Sugeno
    Department of Neurology, Tohoku University School of Medicine, 1 1 Seiryomachi, Aobaku, Sendai, Miyagi 980 8574, Japan
    J Biol Chem 283:23179-88. 2008
  10. doi request reprint Differentiating Parkinson's disease from multiple system atrophy by [123I] meta-iodobenzylguanidine myocardial scintigraphy and olfactory test
    Akio Kikuchi
    Department of Neurology, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai, Miyagi, 980 8574, Japan
    Parkinsonism Relat Disord 17:698-700. 2011

Detail Information

Publications19

  1. pmc The AAA-ATPase VPS4 regulates extracellular secretion and lysosomal targeting of α-synuclein
    Takafumi Hasegawa
    Division of Neurology, Department of Neuroscience and Sensory Organs, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
    PLoS ONE 6:e29460. 2011
    ..Thus, VPS4, a master regulator of MVB sorting, may serve as a determinant of lysosomal targeting or extracellular secretion of αSYN and thereby contribute to the intercellular propagation of Lewy pathology in PD...
  2. doi request reprint Severe olfactory dysfunction is a prodromal symptom of dementia associated with Parkinson's disease: a 3 year longitudinal study
    Toru Baba
    Department of Neurology, Tohoku University Graduate School of Medicine, Sendai 980 8574, Japan
    Brain 135:161-9. 2012
    ....
  3. doi request reprint Role of TPPP/p25 on α-synuclein-mediated oligodendroglial degeneration and the protective effect of SIRT2 inhibition in a cellular model of multiple system atrophy
    Takafumi Hasegawa
    Department of Neurology, Tohoku University School of Medicine, 1 1, Seiryomachi, Aobaku, Sendai, Miyagi 980 8574, Japan
    Neurochem Int 57:857-66. 2010
    ..This apoptotic cell death was partly rescued by sirtuin 2 (SIRT2) inhibition. Together, our results provide further insight into the molecular pathogenesis of MSA and potential therapeutic approaches...
  4. ncbi request reprint Role of Neu4L sialidase and its substrate ganglioside GD3 in neuronal apoptosis induced by catechol metabolites
    Takafumi Hasegawa
    Department of Neurology, Tohoku University School of Medicine, Sendai, Miyagi 980 8574, Japan
    FEBS Lett 581:406-12. 2007
    ..Neu4L and its substrate GD3 may act as key molecules in the mitochondrial apoptotic pathway in neuronal cells...
  5. ncbi request reprint Alpha-synuclein facilitates the toxicity of oxidized catechol metabolites: implications for selective neurodegeneration in Parkinson's disease
    Takafumi Hasegawa
    Department of Neurology, Tohoku University School of Medicine, 1 1 Seiryomachi, Aobaku, Sendai, Miyagi 980 8574, Japan
    FEBS Lett 580:2147-52. 2006
    ..This cellular model may reconstitute the pathological metabolism of alpha-S in the synucleinopathy and provide a useful tool to explore possible pathomechanisms of nigral degeneration in PD...
  6. ncbi request reprint [Cellular pathophysiology of Parkinson's disease]
    Atsushi Takeda
    Division of Neurology, Department of Neuroscience and Sensory Organs, Tohoku University, Graduate School of Medicine
    Rinsho Shinkeigaku 48:984-5. 2008
    ..6) On the other hand, the S129A mutant failed to activate these UPRs. Thus it seems plausible that alpha-synuclein toxicity is dependent on the phosphorylation at S129...
  7. doi request reprint Association of olfactory dysfunction and brain. Metabolism in Parkinson's disease
    Toru Baba
    Department of Neurology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Mov Disord 26:621-8. 2011
    ..Our results suggest that the cognitive deficit in olfactory perception is an important aspect of hyposmia in PD and that this deficit is caused by altered brain metabolism in the amygdala and piriform cortex...
  8. pmc Suppression of dynamin GTPase decreases α-synuclein uptake by neuronal and oligodendroglial cells: a potent therapeutic target for synucleinopathy
    Masatoshi Konno
    Division of Neurology, Department of Neuroscience and Sensory Organs, Tohoku University Graduate School of Medicine, Sendai, Miyagi 980 8574, Japan
    Mol Neurodegener 7:38. 2012
    ..Increasing evidence suggests that these pathogenic proteins may spread to neighboring cells and induce the propagation of neurodegeneration...
  9. ncbi request reprint Serine 129 phosphorylation of alpha-synuclein induces unfolded protein response-mediated cell death
    Naoto Sugeno
    Department of Neurology, Tohoku University School of Medicine, 1 1 Seiryomachi, Aobaku, Sendai, Miyagi 980 8574, Japan
    J Biol Chem 283:23179-88. 2008
    ..Taken together, it seems plausible that alpha-synuclein toxicity is dependent on the phosphorylation at Ser(129) that induces the UPRs, possibly triggered by the disturbed endoplasmic reticulum-Golgi trafficking...
  10. doi request reprint Differentiating Parkinson's disease from multiple system atrophy by [123I] meta-iodobenzylguanidine myocardial scintigraphy and olfactory test
    Akio Kikuchi
    Department of Neurology, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai, Miyagi, 980 8574, Japan
    Parkinsonism Relat Disord 17:698-700. 2011
    ..Our data suggest that the olfactory test can be useful as a clinical tool with its higher specificity in differentiating PD from MSA in the early stages and, moreover, support the discrimination of PD from MSA-P...
  11. ncbi request reprint Olfactory dysfunction and dementia in Parkinson's disease
    Atsushi Takeda
    Department of Neurology, National Hospital Organization, Sendai Nishitgaga Hospital, Kagitori honcho, Taihaku ku, Sendai, Japan
    J Parkinsons Dis 4:181-7. 2014
    ..We hope that this clinical trial will allow us to establish a therapeutic intervention that can improve the prognosis of advanced PD. ..
  12. doi request reprint Functional imaging studies of hyposmia in Parkinson's disease
    Atsushi Takeda
    Division of Neurology, Department of Neuroscience and Sensory Organs, Graduate School of Medicine, Tohoku University, Sendai, Japan
    J Neurol Sci 289:36-9. 2010
    ..Further brain imaging studies of hyposmia will shed light on the early pathological changes in PD...
  13. ncbi request reprint Accelerated alpha-synuclein aggregation after differentiation of SH-SY5Y neuroblastoma cells
    Takafumi Hasegawa
    Department of Neurology, Tohoku University School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai, Miyagi, 980 8574, Japan
    Brain Res 1013:51-9. 2004
    ..This cellular model will enable better understanding of the molecular pathomechanisms of synucleinopathy...
  14. ncbi request reprint Periodic episodes of aphasia as an unusual manifestation of partial status epilepticus
    Takafumi Hasegawa
    Department of Neurology, Tohoku University School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai, Japan
    J Clin Neurosci 12:820-2. 2005
    ..Nonconvulsive partial status epilepticus should be considered in the differential diagnosis of recurrent aphasia, even if the symptoms occur periodically...
  15. ncbi request reprint Transethmoidal intranasal meningoencephalocele in an adult with recurrent meningitis
    Takafumi Hasegawa
    Department of Neurology, Tohoku University School of Medicine, Sendai, Japan
    J Clin Neurosci 12:702-4. 2005
    ..He has had no further meningitis or CSF rhinorrhea post-operatively. Detailed neuroradiological examination and appropriate surgical treatment are important to prevent fatal neurological complications of intranasal meningoencephalocele...
  16. doi request reprint A case with anti-galactocerebroside antibody-positive Mycoplasma pneumoniae meningoencephalitis presenting secondary hypersomnia
    Naoto Sugeno
    Department of Neurology, Tohoku University School of Medicine, 1 1 Seiryomachi, Aobaku, Sendai, 980 0872, Miyagi, Japan
    Neurol Sci 33:1473-6. 2012
    ..The present case further emphasizes the broad spectrum of neurological complications after mycoplasma infection...
  17. ncbi request reprint Increased dopamine and its metabolites in SH-SY5Y neuroblastoma cells that express tyrosinase
    Takafumi Hasegawa
    Department of Neurology, Tohoku University School of Medicine, Sendai, Miyaga, Japan
    J Neurochem 87:470-5. 2003
    ..This cellular model that exhibits increased dopamine production will provide a useful tool for detailed analyses of the potentially noxious effects of oxidized catecholamine metabolites...
  18. ncbi request reprint ["Pathophysiology and clinical presentation of Parkinson's disease-up to date" pathomechanisms of Parkinson's disease]
    Takafumi Hasegawa
    Division of Neurology, Department of Neuroscience and Sensory Organs, Tohoku University Graduate School of Medicine
    Rinsho Shinkeigaku 51:1165-7. 2011
    ..Furthermore, our data from fear-conditioning experiment indicated that the key player in the processing of emotional memories appears to be the amygdala, which has tight connections to primary olfactory areas...
  19. ncbi request reprint Validity and reliability assessment of a Japanese version of the Snaith-Hamilton pleasure scale
    Hiroshi Nagayama
    Department of Internal Medicine, Division of Neurology, Nephrology and Rheumatology, Nippon Medical School, Japan
    Intern Med 51:865-9. 2012
    ..Seventy subjects (48 patients with PD and 22 healthy subjects) were enrolled in this study...