Shozo Furumoto

Summary

Affiliation: Tohoku University
Country: Japan

Publications

  1. ncbi request reprint Recent advances in the development of amyloid imaging agents
    Shozo Furumoto
    Biomedical Engineering Research Organization, Tohoku University, Sendai 980 8575, Japan
    Curr Top Med Chem 7:1773-89. 2007
  2. doi request reprint Amyloid PET in mild cognitive impairment and Alzheimer's disease with BF-227: comparison to FDG-PET
    Katsutoshi Furukawa
    Department of Geriatrics and Gerontology, Division of Brain Sciences, Institute of Development, Aging and Cancer, Tohoku University, 4 1 Seiryomachi, Aobaku, Sendai 980 8498, Japan
    J Neurol 257:721-7. 2010
  3. doi request reprint A modified method of 3D-SSP analysis for amyloid PET imaging using [¹¹C]BF-227
    Tomohiro Kaneta
    Department of Diagnostic Radiology, Tohoku University, 1 1 Seiryomachi, Aobaku, Sendai 980 8574, Japan
    Ann Nucl Med 25:732-9. 2011
  4. doi request reprint Brain accumulation of amyloid β protein visualized by positron emission tomography and BF-227 in Alzheimer's disease patients with or without diabetes mellitus
    Naoki Tomita
    Department of Geriatrics and Gerontology, Division of Brain Sciences, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Miyagi, Japan
    Geriatr Gerontol Int 13:215-21. 2013
  5. doi request reprint Synthesis of [11C]interleukin 8 using a cell-free translation system and L-[11C]methionine
    Ryuichi Harada
    Department of Pharmacology, Tohoku University School of Medicine, Sendai 980 8575, Japan
    Nucl Med Biol 39:155-60. 2012
  6. doi request reprint Comparison study of amyloid PET and voxel-based morphometry analysis in mild cognitive impairment and Alzheimer's disease
    Masaaki Waragai
    Department of Geriatrics and Gerontology, Division of Brain Sciences, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    J Neurol Sci 285:100-8. 2009
  7. doi request reprint Analysis of early phase [11C]BF-227 PET, and its application for anatomical standardization of late-phase images for 3D-SSP analysis
    Tomohiro Kaneta
    Department of Diagnostic Radiology, Tohoku University, 1 1 Seiryomachi, Aobaku, Sendai, 980 8574, Japan
    Jpn J Radiol 32:138-44. 2014
  8. doi request reprint Synthesis and preliminary evaluation of 2-arylhydroxyquinoline derivatives for tau imaging
    Tetsuro Tago
    Cyclotron and Radioisotope Center CYRIC, Tohoku University, Sendai, 980 8578, Japan
    J Labelled Comp Radiopharm 57:18-24. 2014
  9. doi request reprint In vitro and in vivo characterization of 2-deoxy-2-18F-fluoro-D-mannose as a tumor-imaging agent for PET
    Shozo Furumoto
    Department of Pharmacology, Graduate School of Medicine, Tohoku University, Sendai, Japan
    J Nucl Med 54:1354-61. 2013
  10. doi request reprint Advances in molecular imaging for the diagnosis of dementia
    Nobuyuki Okamura
    Tohoku University, Pharmacology, Sendai, Japan
    Expert Opin Med Diagn 3:705-16. 2009

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Recent advances in the development of amyloid imaging agents
    Shozo Furumoto
    Biomedical Engineering Research Organization, Tohoku University, Sendai 980 8575, Japan
    Curr Top Med Chem 7:1773-89. 2007
    ....
  2. doi request reprint Amyloid PET in mild cognitive impairment and Alzheimer's disease with BF-227: comparison to FDG-PET
    Katsutoshi Furukawa
    Department of Geriatrics and Gerontology, Division of Brain Sciences, Institute of Development, Aging and Cancer, Tohoku University, 4 1 Seiryomachi, Aobaku, Sendai 980 8498, Japan
    J Neurol 257:721-7. 2010
    ..We conclude that [(11)C]BF-227-PET has a possibility to be a useful technology for early detection of AD pathology and also even in the MCI stage...
  3. doi request reprint A modified method of 3D-SSP analysis for amyloid PET imaging using [¹¹C]BF-227
    Tomohiro Kaneta
    Department of Diagnostic Radiology, Tohoku University, 1 1 Seiryomachi, Aobaku, Sendai 980 8574, Japan
    Ann Nucl Med 25:732-9. 2011
    ....
  4. doi request reprint Brain accumulation of amyloid β protein visualized by positron emission tomography and BF-227 in Alzheimer's disease patients with or without diabetes mellitus
    Naoki Tomita
    Department of Geriatrics and Gerontology, Division of Brain Sciences, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Miyagi, Japan
    Geriatr Gerontol Int 13:215-21. 2013
    ..To discover the mechanism of developing dementia in AD patients with DM in a living state, we studied the distribution of amyloid β (Αβ) protein of diabetic AD patients...
  5. doi request reprint Synthesis of [11C]interleukin 8 using a cell-free translation system and L-[11C]methionine
    Ryuichi Harada
    Department of Pharmacology, Tohoku University School of Medicine, Sendai 980 8575, Japan
    Nucl Med Biol 39:155-60. 2012
    ..This study clearly demonstrates that cell-free protein production system combined with positron emitter-labeled amino acid holds great promise as a novel approach to prepare radiolabeled proteins and peptides for PET imaging...
  6. doi request reprint Comparison study of amyloid PET and voxel-based morphometry analysis in mild cognitive impairment and Alzheimer's disease
    Masaaki Waragai
    Department of Geriatrics and Gerontology, Division of Brain Sciences, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    J Neurol Sci 285:100-8. 2009
    ..These findings suggest that amyloid PET using [11C]BF-227 is better suited for the prediction of conversion from MCI to AD, while VBM-MRI appears to be better suited for tracking the severity of dementia...
  7. doi request reprint Analysis of early phase [11C]BF-227 PET, and its application for anatomical standardization of late-phase images for 3D-SSP analysis
    Tomohiro Kaneta
    Department of Diagnostic Radiology, Tohoku University, 1 1 Seiryomachi, Aobaku, Sendai, 980 8574, Japan
    Jpn J Radiol 32:138-44. 2014
    ....
  8. doi request reprint Synthesis and preliminary evaluation of 2-arylhydroxyquinoline derivatives for tau imaging
    Tetsuro Tago
    Cyclotron and Radioisotope Center CYRIC, Tohoku University, Sendai, 980 8578, Japan
    J Labelled Comp Radiopharm 57:18-24. 2014
    ..15% ID/g at 30 min postinjection) and showed the labeling of NFTs in an AD brain section by autoradiography assay. These findings indicate the availability of [(11) C]THK-951 for in vivo PET imaging of tau pathology in AD...
  9. doi request reprint In vitro and in vivo characterization of 2-deoxy-2-18F-fluoro-D-mannose as a tumor-imaging agent for PET
    Shozo Furumoto
    Department of Pharmacology, Graduate School of Medicine, Tohoku University, Sendai, Japan
    J Nucl Med 54:1354-61. 2013
    ....
  10. doi request reprint Advances in molecular imaging for the diagnosis of dementia
    Nobuyuki Okamura
    Tohoku University, Pharmacology, Sendai, Japan
    Expert Opin Med Diagn 3:705-16. 2009
    ..New targets for molecular imaging are focusing on protein misfolding diseases associated with the neurotoxic deposition of aggregated tau, α-synuclein and prion proteins...
  11. doi request reprint In vivo detection of amyloid plaques in the mouse brain using the near-infrared fluorescence probe THK-265
    Nobuyuki Okamura
    Department of Pharmacology, Tohoku University School of Medicine, Sendai, Japan Innovation of New Biomedical Engineering Center, Tohoku University, Sendai, Japan
    J Alzheimers Dis 23:37-48. 2011
    ..These findings strongly support the usefulness of THK-265 as an NIRF imaging probe for the noninvasive measurement of brain amyloid load...
  12. ncbi request reprint Initial evaluation of dynamic human imaging using 18F-FRP170 as a new PET tracer for imaging hypoxia
    Tomohiro Kaneta
    Department of Diagnostic Radiology, Tohoku University, Sendai, Japan
    Ann Nucl Med 21:101-7. 2007
    ..In the present study, we analyzed dynamic whole-body imaging in healthy volunteers and dynamic tumor imaging in three patients with lung cancer...
  13. ncbi request reprint Tumor detection using 18F-labeled matrix metalloproteinase-2 inhibitor
    Shozo Furumoto
    Institute of Development, Aging and Cancer and Graduate School of Pharmaceutical Scinces, Tohoku University, Sendai, Japan
    Nucl Med Biol 30:119-25. 2003
    ..Our results suggest that [(18)F]SAV03M could be potentially suitable for tumor imaging with PET...
  14. ncbi request reprint An experimental study on O-[18F]fluoromethyl-L-tyrosine for differentiation between tumor and inflammatory tissues
    Manami Suzuki
    Division of Nuclear Medicine, Cyclotron and Radioisotope Center, Tohoku University, Aoba, Aramaki, Aoba, Sendai, Miyagi 980 8578, Japan
    Ann Nucl Med 19:589-95. 2005
    ..The aim of this study was to assess the potency of 18F-FMT for differentiating tumor and inflammatory tissues using an animal model with an implanted tumor and experimentally induced inflammatory foci...
  15. doi request reprint Tumor blood flow interruption after radiotherapy strongly inhibits tumor regrowth
    Katsuyoshi Hori
    Department of Vascular Biology, Division of Cancer Control, Institute of Development, Aging and Cancer, Tohoku University, 4 1 Seiryomachi, Aoba ku, Sendai 980 8575, Japan
    Cancer Sci 99:1485-91. 2008
    ..Our data thus show that destruction of tumor microcirculation after irradiation is quite effective for preventing cancer recurrence...
  16. ncbi request reprint Synthesis and in vivo biodistribution of BPA-Gd-DTPA complex as a potential MRI contrast carrier for neutron capture therapy
    Kazunori Takahashi
    Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980 8578, Japan
    Bioorg Med Chem 13:735-43. 2005
    ..The visualization experiment of boron distribution in the tumor-bearing rat by alpha-autoradiography indicates that boron was accumulated in the tumor and the intestines at 20 min after injection...
  17. doi request reprint Reactivity of electrochemically concentrated anhydrous [18F]fluoride for microfluidic radiosynthesis of 18F-labeled compounds
    Rebecca Wong
    Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980 8578, Japan
    Appl Radiat Isot 70:193-9. 2012
    ....
  18. ncbi request reprint O-[18F]fluoromethyl-L-tyrosine is a potential tracer for monitoring tumour response to chemotherapy using PET: an initial comparative in vivo study with deoxyglucose and thymidine
    Gengo Yamaura
    Department of Clinical Oncology, Institute of Development, Aging and Cancer, Tohoku University, 4 1 Seiryo machi, Aoba Ward, Sendai 980 8575, Japan
    Eur J Nucl Med Mol Imaging 33:1134-9. 2006
    ..To compare the utility of a new artificial amino acid, O-[18F]fluoromethyl-L-tyrosine ([18F]FMT), for monitoring cancer chemotherapy with deoxyglucose and thymidine...
  19. ncbi request reprint [Development of [18F]FRP-170 injection for imaging hypoxia by PET]
    Yoichi Ishikawa
    Cyclotron and Radioisotope Center, Tohoku University
    Kaku Igaku 42:1-10. 2005
    ..The radiation-absorbed dose to the whole body was estimated to be 1.0 mSv/185 MBq. The [18F]FRP-170 injection proved to be suitable for clinical use without acute toxicity or mutagenicity...
  20. ncbi request reprint Quinoline and benzimidazole derivatives: candidate probes for in vivo imaging of tau pathology in Alzheimer's disease
    Nobuyuki Okamura
    BF Research Institute, Osaka 541 0045, Japan
    J Neurosci 25:10857-62. 2005
    ..Autoradiography using 11C-labeled BF-158 further demonstrated labeling of NFTs in AD brain sections. These findings suggest the potential usefulness of quinoline and benzimidazole derivatives for in vivo imaging of tau pathology in AD...
  21. ncbi request reprint 2-(2-[2-Dimethylaminothiazol-5-yl]ethenyl)-6- (2-[fluoro]ethoxy)benzoxazole: a novel PET agent for in vivo detection of dense amyloid plaques in Alzheimer's disease patients
    Yukitsuka Kudo
    Tohoku University Biomedical Engineering Research Organization, Sendai, Japan
    J Nucl Med 48:553-61. 2007
    ..This study reports a novel compound, 2-(2-[2-dimethylaminothiazol-5-yl]ethenyl)-6-(2-[fluoro]ethoxy)benzoxazole (BF-227), for in vivo detection of dense amyloid deposits using PET...
  22. ncbi request reprint Evaluation of O-[11C]methyl-L-tyrosine and O-[18F]fluoromethyl-L-tyrosine as tumor imaging tracers by PET
    Kiichi Ishiwata
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, 1 1 Naka cho, Itabashi ku, Tokyo 173 0022, Japan
    Nucl Med Biol 31:191-8. 2004
    ..O-[(11)C]methyl-L-tyrosine was metabolically stable, whereas a negligible low amount of metabolites was observed for O-[(18)F]fluoromethyl-L-tyrosine. Both tracers showed the potential for tumor imaging...
  23. ncbi request reprint Comparison of 18F-fluoromethylcholine and 2-deoxy-D-glucose in the distribution of tumor and inflammation
    Kazuo Kubota
    Division of Nuclear Medicine, Department of Radiology, International Medical Center of Japan, Tokyo, Japan
    Ann Nucl Med 20:527-33. 2006
    ..The distribution characteristics of 18F-fluoromethylcholine (18F-choline) in tumor and inflammatory tissue were compared with those of 14C or 3H-2-deoxyglucose (2DG) as a substitute for fluorodeoxyglucose (FDG)...
  24. ncbi request reprint Simple automated preparation of O-[11C]methyl-l-tyrosine for routine clinical use
    Yoichi Ishikawa
    CYRIC Tohoku University, Aramaki, Aoba ku, Sendai 980 8578, Japan
    Appl Radiat Isot 63:55-61. 2005
    ..60% (decay-corrected, based on [(11)C]MeI). Radiochemical purity was over 97%. The automated preparation was carried out using a miniature module employing manifold valves...
  25. ncbi request reprint [Alzheimer' s disease]
    Nobuyuki Okamura
    Department of Pharmacology, Tohoku University Graduate School of Medicine
    Nihon Rinsho 65:320-6. 2007
    ....