Toru Furukawa

Summary

Affiliation: Tohoku University
Country: Japan

Publications

  1. ncbi request reprint Classification of types of intraductal papillary-mucinous neoplasm of the pancreas: a consensus study
    Toru Furukawa
    Department of Molecular Pathology, Tohoku University School of Medicine, 2 1 Seiryomachi, Sendai, 980 8575, Japan
    Virchows Arch 447:794-9. 2005
  2. ncbi request reprint Distinct progression pathways involving the dysfunction of DUSP6/MKP-3 in pancreatic intraepithelial neoplasia and intraductal papillary-mucinous neoplasms of the pancreas
    Toru Furukawa
    Department of Molecular Pathology, Tohoku University School of Medicine, Sendai, Japan
    Mod Pathol 18:1034-42. 2005
  3. ncbi request reprint Molecular pathology of pancreatic cancer: in quest of tumor suppressor genes
    Toru Furukawa
    Department of Molecular Pathology, Tohoku University School of Medicine, Sendai, Miyagi, Japan
    Pancreas 28:253-6. 2004
  4. ncbi request reprint Chromosome 12, frequently deleted in human pancreatic cancer, may encode a tumor-suppressor gene that suppresses angiogenesis
    Sumitaka Yamanaka
    Department of Molecular Pathology, Tohoku University School of Medicine, Sendai, Japan
    Lab Invest 84:1339-51. 2004
  5. ncbi request reprint The PMAIP1 gene on chromosome 18 is a candidate tumor suppressor gene in human pancreatic cancer
    Masaharu Ishida
    Department of Molecular Pathology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, Japan
    Dig Dis Sci 53:2576-82. 2008
  6. ncbi request reprint Characteristic clinicopathological features of the types of intraductal papillary-mucinous neoplasms of the pancreas
    Masaharu Ishida
    Department of Gastroenterological Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan
    Pancreas 35:348-52. 2007
  7. ncbi request reprint Inserting chromosome 18 into pancreatic cancer cells switches them to a dormant metastatic phenotype
    Liviu P Lefter
    Department of Molecular Pathology, Tohoku University School of Medicine, Sendai 980 8575, Japan
    Clin Cancer Res 9:5044-52. 2003
  8. doi request reprint RNA interference targeting against S100A4 suppresses cell growth and motility and induces apoptosis in human pancreatic cancer cells
    Takahiro Tabata
    Department of Molecular Pathology, Tohoku University School of Medicine, Sendai, Miyagi 980 8575, Japan
    Biochem Biophys Res Commun 390:475-80. 2009
  9. ncbi request reprint The role of chromosome 18 abnormalities in the progression of pancreatic adenocarcinoma
    Makoto Sunamura
    Department of Gastroenterological Surgery, Tohoku University School of Medicine, Sendai, Japan
    Pancreas 28:311-6. 2004
  10. doi request reprint A cDNA microarray analysis identifies 52 genes associated with cis-diamminedichloroplatinum susceptibility in head and neck squamous cell carcinoma cell lines
    Takenori Ogawa
    Department of Molecular Pathology, Tohoku University School of Medicine, Sendai Miyagi 980 8575, Japan
    Eur Arch Otorhinolaryngol 267:123-9. 2010

Detail Information

Publications38

  1. ncbi request reprint Classification of types of intraductal papillary-mucinous neoplasm of the pancreas: a consensus study
    Toru Furukawa
    Department of Molecular Pathology, Tohoku University School of Medicine, 2 1 Seiryomachi, Sendai, 980 8575, Japan
    Virchows Arch 447:794-9. 2005
    ..These definitions can be used for further analyses of the clinicopathological significance of the variations of IPMN...
  2. ncbi request reprint Distinct progression pathways involving the dysfunction of DUSP6/MKP-3 in pancreatic intraepithelial neoplasia and intraductal papillary-mucinous neoplasms of the pancreas
    Toru Furukawa
    Department of Molecular Pathology, Tohoku University School of Medicine, Sendai, Japan
    Mod Pathol 18:1034-42. 2005
    ....
  3. ncbi request reprint Molecular pathology of pancreatic cancer: in quest of tumor suppressor genes
    Toru Furukawa
    Department of Molecular Pathology, Tohoku University School of Medicine, Sendai, Miyagi, Japan
    Pancreas 28:253-6. 2004
    ..We continue work to more completely understand the complex molecular mechanisms of pancreatic carcinogenesis and to apply the information gained to the clinical treatment of pancreatic cancer...
  4. ncbi request reprint Chromosome 12, frequently deleted in human pancreatic cancer, may encode a tumor-suppressor gene that suppresses angiogenesis
    Sumitaka Yamanaka
    Department of Molecular Pathology, Tohoku University School of Medicine, Sendai, Japan
    Lab Invest 84:1339-51. 2004
    ..In summary, this study provides the first functional evidence of the existence of an additional tumor-suppressor gene(s) on chromosome 12, whose absence is responsible for the pathogenesis in pancreatic ductal carcinogenesis...
  5. ncbi request reprint The PMAIP1 gene on chromosome 18 is a candidate tumor suppressor gene in human pancreatic cancer
    Masaharu Ishida
    Department of Molecular Pathology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, Japan
    Dig Dis Sci 53:2576-82. 2008
    ..These results suggest that PMAIP1 may play an important role in the progression of pancreatic cancer...
  6. ncbi request reprint Characteristic clinicopathological features of the types of intraductal papillary-mucinous neoplasms of the pancreas
    Masaharu Ishida
    Department of Gastroenterological Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan
    Pancreas 35:348-52. 2007
    ..The purpose of this study was to determine associations between the histological types and clinicopathological features in patients with IPMN...
  7. ncbi request reprint Inserting chromosome 18 into pancreatic cancer cells switches them to a dormant metastatic phenotype
    Liviu P Lefter
    Department of Molecular Pathology, Tohoku University School of Medicine, Sendai 980 8575, Japan
    Clin Cancer Res 9:5044-52. 2003
    ..These data represent the first functional evidence suggesting that chromosome 18q encodes a gene that strongly suppresses metastatic activity, possibly through dormancy...
  8. doi request reprint RNA interference targeting against S100A4 suppresses cell growth and motility and induces apoptosis in human pancreatic cancer cells
    Takahiro Tabata
    Department of Molecular Pathology, Tohoku University School of Medicine, Sendai, Miyagi 980 8575, Japan
    Biochem Biophys Res Commun 390:475-80. 2009
    ..Our present results suggest the possibility that the inhibition of S100A4 can be utilized in antitumor applications for patients with pancreatic cancer...
  9. ncbi request reprint The role of chromosome 18 abnormalities in the progression of pancreatic adenocarcinoma
    Makoto Sunamura
    Department of Gastroenterological Surgery, Tohoku University School of Medicine, Sendai, Japan
    Pancreas 28:311-6. 2004
    ..It was revealed that there was increased expression of 4 genes relating to apoptosis in the 18 chromosome hybrids cells compared with the parental cells. We are now analyzing the function of these genes...
  10. doi request reprint A cDNA microarray analysis identifies 52 genes associated with cis-diamminedichloroplatinum susceptibility in head and neck squamous cell carcinoma cell lines
    Takenori Ogawa
    Department of Molecular Pathology, Tohoku University School of Medicine, Sendai Miyagi 980 8575, Japan
    Eur Arch Otorhinolaryngol 267:123-9. 2010
    ..Our present results give us valuable clues to better understand the chemosensitivities of such cells to CDDP. This will improve the clinical management of patients with HNSCC...
  11. ncbi request reprint RNA interference targeting aurora kinase a suppresses tumor growth and enhances the taxane chemosensitivity in human pancreatic cancer cells
    Tatsuo Hata
    Department of Molecular Pathology, Tohoku University School of Medicine, Sendai Miyagi, Japan
    Cancer Res 65:2899-905. 2005
    ..These results indicate that inhibition of AURKA expression can result in potent antitumor activity and chemosensitizing activity to taxanes in human pancreatic cancer...
  12. ncbi request reprint Elucidation of the relationship of BNIP3 expression to gemcitabine chemosensitivity and prognosis
    Masaharu Ishida
    Department of Molecular Pathology, Tohoku University School of Medicine, 2 1 Seiryo machi, Sendai, Japan
    World J Gastroenterol 13:4593-7. 2007
    ....
  13. ncbi request reprint DSCP1, a novel TP53-inducible gene, is upregulated by strong genotoxic stresses and its overexpression inhibits tumor cell growth in vitro
    Tatsuo Hata
    Department of Molecular Pathology, Tohoku University School of Medicine, Sendai, Miyagi, Japan
    Int J Oncol 24:513-20. 2004
    ..These results indicate that DSCP1 is a stress-inducible gene in both a TP53 dependent and independent manner and that its protein product can inhibit cancer cell growth...
  14. ncbi request reprint Abrogation of DUSP6 by hypermethylation in human pancreatic cancer
    Shanhai Xu
    Department of Molecular Pathology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    J Hum Genet 50:159-67. 2005
    ..Our combined results suggest that hypermethylation with modification of histone deacetylation play an important role in transcriptional suppression of DUSP6 in human pancreatic cancer...
  15. ncbi request reprint TU12B1-TY, a novel gene in the region at 12q22-q23.1 frequently deleted in pancreatic cancer, shows reduced expression in pancreatic cancer cells
    Toshimasa Yatsuoka
    Department of Molecular Pathology, Tohoku University School of Medicine, Miyagi 980 8575, Japan
    Oncol Rep 12:1263-8. 2004
    ..The present results indicate that reduced function of TU12B1-TY may contribute to the development and/or progression of human pancreatic cancer...
  16. ncbi request reprint Intraductal papillary-mucinous adenocarcinoma in the remnant pancreas after pancreatoduodenectomy for cancer of Vater's papilla associated with intraductal papillary-mucinous adenoma
    Masaharu Ishida
    Department of Gastroenterological Surgery, Tohoku University Graduate School of Medicine, 1 1 Seiryocho, Aobaku, Sendai, 980 8574, Japan
    J Hepatobiliary Pancreat Surg 14:522-5. 2007
    ..These findings suggest that careful surveillance of the gastrointestinal tract and careful follow up are necessary for IPMN, because an IPMN could be associated with other gastrointestinal tract malignancies...
  17. ncbi request reprint Blockade of delta-like ligand 4 signaling inhibits both growth and angiogenesis of pancreatic cancer
    Hidekazu Oishi
    Division of Hepato Biliary Pancreatic Surgery, Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan
    Pancreas 39:897-903. 2010
    ..In this study, we examined the effects of the DLL4-Notch signaling on tumor angiogenesis using the neutralizing monoclonal antibodies against DLL4...
  18. pmc Potential tumor suppressive pathway involving DUSP6/MKP-3 in pancreatic cancer
    Toru Furukawa
    Department of Molecular Pathology, Tohoku University School of Medicine, Sendai, Japan
    Am J Pathol 162:1807-15. 2003
    ..These results show that DUSP6 exerts apparent tumor-suppressive effects in vitro and suggest that DUSP6 is a strong candidate tumor suppressor gene at 12q22 locus...
  19. doi request reprint Synchronous and metachronous extrapancreatic malignant neoplasms in patients with intraductal papillary-mucinous neoplasm of the pancreas
    Masaharu Ishida
    Department of Gastroenterological Surgery, Tohoku University Graduate School of Medicine, Aoba ku, Sendai, Japan
    Pancreatology 8:577-82. 2008
    ..Recently there have been some reports on extrapancreatic malignant neoplasms (EPM) occurring in patients with IPMN. The purpose of this study was to discover the characteristic features of IPMN with EPM compared with IPMN without EPM...
  20. doi request reprint Upregulation of IGF2 is associated with an acquired resistance for cis-diamminedichloroplatinum in human head and neck squamous cell carcinoma
    Takenori Ogawa
    Department of Molecular Pathology, Tohoku University School of Medicine, Sendai, Miyagi, 980 8575, Japan
    Eur Arch Otorhinolaryngol 267:1599-606. 2010
    ..These findings suggest the possibility for developing a new strategy for treating patients with HNSCC, particularly those with acquired CDDP resistance, by combining CDDP with inhibition of the IGF2 pathway...
  21. ncbi request reprint Suppression of the tumorigenic phenotype by chromosome 18 transfer into pancreatic cancer cell lines
    Liviu P Lefter
    Department of Molecular Pathology, Tohoku University School of Medicine, Sendai, Japan
    Genes Chromosomes Cancer 34:234-42. 2002
    ....
  22. doi request reprint A GNAS mutation found in pancreatic intraductal papillary mucinous neoplasms induces drastic alterations of gene expression profiles with upregulation of mucin genes
    Hirotake Komatsu
    Institute for Integrated Medical Sciences, Tokyo Women s Medical University, Tokyo, Japan Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan
    PLoS ONE 9:e87875. 2014
    ..PK-8 cells expressing exogenous mutated GNAS may be an ideal in vitro model of IPMN. ..
  23. ncbi request reprint [Mechanistic insights for pancreatic carcinogenesis]
    Toru Furukawa
    Department of Molecular Pathology, Tohoku University School of Medicine
    Nihon Rinsho 64:27-31. 2006
  24. doi request reprint Molecular events in human T cells treated with diesel exhaust particles or formaldehyde that underlie their diminished interferon-gamma and interleukin-10 production
    Yoshinori Sasaki
    Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Int Arch Allergy Immunol 148:239-50. 2009
    ..A series of epidemiological and experimental studies have suggested that diesel exhaust particles (DEP) and formaldehyde (FA) may help trigger T helper type 2 (Th2)-mediated allergic responses...
  25. ncbi request reprint Infrequent mutation of APC, AXIN1, and GSK3B in human pituitary adenomas with abnormal accumulation of CTNNB1
    Chunlan Sun
    Department of Molecular Pathology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    J Neurooncol 73:131-4. 2005
    ..However, the possibility that mutation of regions outside of our survey or epigenetic mechanism play an important role cannot be excluded...
  26. ncbi request reprint APAF-1-ALT, a novel alternative splicing form of APAF-1, potentially causes impeded ability of undergoing DNA damage-induced apoptosis in the LNCaP human prostate cancer cell line
    Takenori Ogawa
    Department of Molecular Pathology, Tohoku University School of Medicine, Sendai, Miyagi 980 8575, Japan
    Biochem Biophys Res Commun 306:537-43. 2003
    ..These results indicate that APAF-1-ALT is a molecule that is deficient and impeded for mediating apoptosis and that it may contribute to the resistance to DNA damage-induced treatment observed in LNCaP...
  27. ncbi request reprint Molecular mechanisms of pancreatic carcinogenesis
    Toru Furukawa
    Department of Molecular Pathology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Cancer Sci 97:1-7. 2006
    ..Understanding the molecular mechanisms of pancreatic carcinogenesis will likely provide novel clues for preventing, detecting, and ultimately curing this life-threatening disease...
  28. pmc E4F1, a novel estrogen-responsive gene in possible atheroprotection, revealed by microarray analysis
    Yasuhiro Nakamura
    Department of Pathology, Tohoku University School of Medicine, Aoba ku, Sendai 980 8575, Japan
    Am J Pathol 165:2019-31. 2004
    ..E4F1 is therefore considered one of the estrogen-responsive genes involving ER alpha-mediated inhibition of VSMC proliferation and may play an important role in estrogen-related atheroprotection of human aorta...
  29. ncbi request reprint Pathologic aspects of intraductal papillary-mucinous neoplasm and pancreatic intraepithelial neoplasia--their associations with carcinogenesis
    Toru Furukawa
    International Research and Educational Institute for Integrated Medical Sciences, Tokyo Women s Medical University
    Nihon Shokakibyo Gakkai Zasshi 104:1329-37. 2007
  30. ncbi request reprint Restoration of SMAD4 by gene therapy reverses the invasive phenotype in pancreatic adenocarcinoma cells
    Dan G Duda
    Division of Gastroenterological Surgery, Graduate School of Medicine, Tohoku University, 980 8574 Sendai, Japan
    Oncogene 22:6857-64. 2003
    ..ETS-1 is considered a marker for tumour invasion. Upon SMAD4 deletion, we detected high expression levels of ETS-1 in pancreatic tumour cells, suggesting the shift of the pancreatic tumour toward an invasive phenotype...
  31. ncbi request reprint Cystic neoplasm of the pancreas: a Japanese multiinstitutional study of intraductal papillary mucinous tumor and mucinous cystic tumor
    Yutaka Suzuki
    Department of Surgery, Kyorin University School of Medicine, Tokyo, Japan
    Pancreas 28:241-6. 2004
    ..5% in invasive carcinoma cases. In conclusion, IPMT and MCT show distinct clinicopathologic and prognostic differences. The results from this study may contribute to the diagnosis and treatment of IPMT and MCT...
  32. ncbi request reprint Functional analysis of chromosome 18 in pancreatic cancer: strong evidence for new tumour suppressor genes
    Liviu P Lefter
    Departments of Gastrointestinal Surgery and Molecular Pathology, Tohoku University Graduate School of Medicine, 1 1 Seiryomachi, Aoba ku, Sendai 980 8574, Japan
    Asian J Surg 27:85-92. 2004
    ..This study was intended to provide functional evidence for the existence of new tumour suppressor gene(s) located on chromosome 18...
  33. ncbi request reprint Elevated expression of mitogen-activated protein kinase phosphatase 3 in breast tumors: a mechanism of tamoxifen resistance
    Yukun Cui
    Breast Center and Department of Medicine, Baylor College of Medicine, Houston, Texas, USA
    Cancer Res 66:5950-9. 2006
    ..MKP3 represents a novel mechanism of resistance, which may be a potential biomarker for the use of ERK1/2 and/or JNK inhibitors in combination with tamoxifen treatment...
  34. ncbi request reprint An illustrated consensus on the classification of pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms
    Ralph H Hruban
    Department of Pathology, The Johns Hopkins Medical Institutions, 401 N Broadway, Weinberg 2242, Baltimore, MD 21231 2410, USA
    Am J Surg Pathol 28:977-87. 2004
    ..We present a consensus classification of the precursor lesions in the pancreatic ducts, PanINs and IPMNs...
  35. doi request reprint Loss of MKP3 mediated by oxidative stress enhances tumorigenicity and chemoresistance of ovarian cancer cells
    David W Chan
    Department of Obstetrics and Gynecology, Li Ka Shing Faculty of Medicine, TheUniversity of Hong Kong, Hong Kong SAR, People s Republic of China
    Carcinogenesis 29:1742-50. 2008
    ....
  36. ncbi request reprint Molecular genetics of intraductal papillary-mucinous neoplasms of the pancreas
    Toru Furukawa
    International Research and Educational Institute for Integrated Medical Sciences, Tokyo Women s Medical University, Tokyo 162 8666, Japan
    J Hepatobiliary Pancreat Surg 14:233-7. 2007
    ..Alterations of KRAS, AKT/PKB, CDKN2A, TP53, SMAD4, STK11/LKB1, and DUSP6, and other molecular alterations, including global expression studies as well as their clinical implications, are discussed...
  37. ncbi request reprint Screening for functional tumor suppressor activity in pancreatic cancer
    Liviu Lefter
    3rd Department of Surgery, St Spiridon University Hospital, Iasi, Romania
    Rom J Gastroenterol 13:195-201. 2004
    ..The functional data emerging from this study bring into sharp relief the implication of chromosome 18 as a putative location for new TSG(s), yet to be identified in this region...
  38. ncbi request reprint Pathology of genetically engineered mouse models of pancreatic exocrine cancer: consensus report and recommendations
    Ralph H Hruban
    Department of Pathology, The Sol Goldman Center for Pancreatic Cancer Research, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Cancer Res 66:95-106. 2006
    ....