Tohru Fujiwara

Summary

Affiliation: Tohoku University
Country: Japan

Publications

  1. ncbi request reprint Blood pressure control assessed by home, ambulatory and conventional blood pressure measurements in the Japanese general population: the Ohasama study
    Atsushi Hozawa
    Department of Public Health, Tohoku University Graduate School of Medicine and Pharmaceutical Science, Sendai, Japan
    Hypertens Res 25:57-63. 2002
  2. ncbi request reprint Aggressive B-cell lymphoma with dual surface immunoglobulin light-chain expression
    Tohru Fujiwara
    Department of Rheumatology and Hematology, Tohoku University Graduate School of Medicine, Sendai
    Intern Med 46:1458-61. 2007
  3. ncbi request reprint Primary effusion lymphoma of the pericardial cavity carrying t(1;22)(q21;q11) and t(14;17)(q32;q23)
    Tohru Fujiwara
    Department of Rheumatology, Tohoku University Graduate School of Medicine, 1 1 Seiryomachi, Aoba ku, Sendai 980 8574, Japan
    Cancer Genet Cytogenet 156:49-53. 2005
  4. ncbi request reprint Expression analyses and transcriptional regulation of mouse nucleolar spindle-associated protein gene in erythroid cells: essential role of NF-Y
    Tohru Fujiwara
    Department of Rheumatology and Haematology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Br J Haematol 135:583-90. 2006
  5. doi request reprint Elucidation of the role of LMO2 in human erythroid cells
    Ai Inoue
    Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Exp Hematol 41:1062-76.e1. 2013
  6. doi request reprint Role of transcriptional corepressor ETO2 in erythroid cells
    Tohru Fujiwara
    Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Exp Hematol 41:303-15.e1. 2013
  7. ncbi request reprint Imatinib mesylate in conjunction with allogeneic hematopoietic stem cell transplantation in patients with Philadelphia chromosome positive leukemias: report of 4 cases
    Minami Yamada
    Department of Rheumatology and Hematology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Tohoku J Exp Med 204:79-84. 2004
  8. pmc GATA2 regulates differentiation of bone marrow-derived mesenchymal stem cells
    Mayumi Kamata
    Departments of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Haematologica 99:1686-96. 2014
  9. pmc Gene expression profiling identifies HOXB4 as a direct downstream target of GATA-2 in human CD34+ hematopoietic cells
    Tohru Fujiwara
    Molecular Hematology Oncology, Tohoku University Graduate School of Medicine, Sendai, Japan
    PLoS ONE 7:e40959. 2012
  10. ncbi request reprint A case of familial thrombocytosis: possible role of altered thrombopoietin production
    Tohru Fujiwara
    Department of Rheumatology and Hematology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Am J Hematol 76:395-7. 2004

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Blood pressure control assessed by home, ambulatory and conventional blood pressure measurements in the Japanese general population: the Ohasama study
    Atsushi Hozawa
    Department of Public Health, Tohoku University Graduate School of Medicine and Pharmaceutical Science, Sendai, Japan
    Hypertens Res 25:57-63. 2002
    ....
  2. ncbi request reprint Aggressive B-cell lymphoma with dual surface immunoglobulin light-chain expression
    Tohru Fujiwara
    Department of Rheumatology and Hematology, Tohoku University Graduate School of Medicine, Sendai
    Intern Med 46:1458-61. 2007
    ..To our knowledge, this is the first case of aggressive B-cell lymphoma showing dual kappa/lambda expression; the possible mechanisms of abnormal light chain expression are discussed...
  3. ncbi request reprint Primary effusion lymphoma of the pericardial cavity carrying t(1;22)(q21;q11) and t(14;17)(q32;q23)
    Tohru Fujiwara
    Department of Rheumatology, Tohoku University Graduate School of Medicine, 1 1 Seiryomachi, Aoba ku, Sendai 980 8574, Japan
    Cancer Genet Cytogenet 156:49-53. 2005
    ..The present case demonstrated a rare category of PEL that is not associated with HHV-8 or C-MYC gene rearrangement. In addition, SKY analysis disclosed cryptic chromosomal abnormalities involving 1q21 and 17q23...
  4. ncbi request reprint Expression analyses and transcriptional regulation of mouse nucleolar spindle-associated protein gene in erythroid cells: essential role of NF-Y
    Tohru Fujiwara
    Department of Rheumatology and Haematology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Br J Haematol 135:583-90. 2006
    ..Furthermore, the promoter was trans-activated by NF-YA through these elements. These results suggest that NuSAP might play an important role in erythroid proliferation under the control of NF-Y...
  5. doi request reprint Elucidation of the role of LMO2 in human erythroid cells
    Ai Inoue
    Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Exp Hematol 41:1062-76.e1. 2013
    ..LMO2 contributes to GATA-1 target gene expression by affecting assembly of the GATA-SCL/TAL1 complex components at endogenous loci...
  6. doi request reprint Role of transcriptional corepressor ETO2 in erythroid cells
    Tohru Fujiwara
    Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Exp Hematol 41:303-15.e1. 2013
    ..In summary, ETO2 regulates GATA-1 target genes critical for erythroid differentiation, and the decrease of ETO2 levels during erythroid differentiation would contribute to the activation of these targets...
  7. ncbi request reprint Imatinib mesylate in conjunction with allogeneic hematopoietic stem cell transplantation in patients with Philadelphia chromosome positive leukemias: report of 4 cases
    Minami Yamada
    Department of Rheumatology and Hematology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Tohoku J Exp Med 204:79-84. 2004
    ..Our data suggest that imatinib in conjunction with SCT for the Ph+ leukemia may be a promising treatment strategy...
  8. pmc GATA2 regulates differentiation of bone marrow-derived mesenchymal stem cells
    Mayumi Kamata
    Departments of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Haematologica 99:1686-96. 2014
    ....
  9. pmc Gene expression profiling identifies HOXB4 as a direct downstream target of GATA-2 in human CD34+ hematopoietic cells
    Tohru Fujiwara
    Molecular Hematology Oncology, Tohoku University Graduate School of Medicine, Sendai, Japan
    PLoS ONE 7:e40959. 2012
    ..6573, p<0.01). Our results suggested that GATA-2 directly regulates HOXB4 expression in hematopoietic stem cells, which may play an important role in the development and/or progression of aplastic anemia...
  10. ncbi request reprint A case of familial thrombocytosis: possible role of altered thrombopoietin production
    Tohru Fujiwara
    Department of Rheumatology and Hematology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Am J Hematol 76:395-7. 2004
    ..Platelet c-MPL expression was similar or slightly increased as compared to normal volunteers. These data suggest that altered regulation of the TPO gene might be involved in the pathogenesis of FT...
  11. doi request reprint Induction of thymic stromal lymphopoietin in mesenchymal stem cells by interaction with myeloma cells
    Shinji Nakajima
    Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Leuk Lymphoma 55:2605-13. 2014
    ..These results suggested that MM cells positively act to induce various molecules in MSCs, leading to the formation of a more advantageous BM microenvironment for their survival...
  12. pmc A low-molecular-weight compound K7174 represses hepcidin: possible therapeutic strategy against anemia of chronic disease
    Tohru Fujiwara
    Department of Hematology and Rheumatology, Tohoku University Graduate School, Sendai, Japan Molecular Hematology Oncology, Tohoku University Graduate School, Sendai, Japan
    PLoS ONE 8:e75568. 2013
    ..In conclusion, K7174 inhibits hepcidin expression partly by inducing GDF15. K-7174 may be a potential therapeutic option to treat anemia of chronic disease. ..
  13. ncbi request reprint Over-expression of Flt3 induces NF-kappaB pathway and increases the expression of IL-6
    Shinichiro Takahashi
    Department of Clinical Laboratory Medicine, Tohoku University School of Medicine, 1 1 Seiryou Machi, Aobaku, Sendai 980 8574, Japan
    Leuk Res 29:893-9. 2005
    ..Furthermore, we found a modest positive correlation (r=0.35, p=0.096) between Flt3 and IL-6 mRNA expression in 24 AML specimens. These results suggest a role of Flt3 over-expression in NF-kappaB pathway...
  14. ncbi request reprint Induction of erythroid-specific genes by overexpression of GATA-2 in K562 cells
    Hideo Harigae
    Department of Rheumatology and Hematology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Int J Hematol 84:38-42. 2006
    ....
  15. doi request reprint Effect of 5-aminolevulinic acid on erythropoiesis: a preclinical in vitro characterization for the treatment of congenital sideroblastic anemia
    Tohru Fujiwara
    Department of Hematology and Rheumatology, Tohoku University Graduate School, Sendai, Japan Department of Molecular Hematology Oncology, Tohoku University Graduate School, Sendai, Japan
    Biochem Biophys Res Commun 454:102-8. 2014
    ..In summary, ALA appears to be transported into erythroid cells mainly by SLC36A1 and is utilized to generate heme. ALA may represent a novel therapeutic option for CSA treatment, particularly for cases harboring ALAS2 mutations. ..
  16. pmc High-Throughput siRNA Screening to Reveal GATA-2 Upstream Transcriptional Mechanisms in Hematopoietic Cells
    Yo Saito
    Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan
    PLoS ONE 10:e0137079. 2015
    ..Subsequently, we screened 995 transcription factor genes and revealed that CITED2 acts as a GATA-2 activator in human hematopoietic cells. These results provide novel insights into and further identify the regulatory mechanism of GATA-2...
  17. ncbi request reprint Diagnosis of intestinal graft-versus-host disease and thrombotic microangiopathy after allogeneic stem cell transplantation
    Minami Yamada-Fujiwara
    Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Tohoku J Exp Med 227:31-7. 2012
    ..The present study may provide a clue on making clinical diagnosis of patients with watery diarrhea after HSCT, which enables us to start a prompt therapy...
  18. ncbi request reprint Fludarabine- and cyclophosphamide-based nonmyeloablative conditioning regimen for transplantation of chronic granulomatous disease: possible correlation with prolonged pure red cell aplasia
    Tohru Fujiwara
    Department of Rheumatology and Hematology, Tohoku University School of Medicine, Sendai, Japan
    Int J Hematol 79:293-7. 2004
    ..In the setting of major ABO-incompatible NSCT, a fludarabine- and cyclophosphamide-based conditioning regimen may lead to prolonged PRCA...
  19. pmc Identification of acquired mutations by whole-genome sequencing in GATA-2 deficiency evolving into myelodysplasia and acute leukemia
    Tohru Fujiwara
    Department of Hematology and Rheumatology, Tohoku University Graduate School, 2 1 Seiryo cho, Aoba ku, Sendai, 980 8575, Japan
    Ann Hematol 93:1515-22. 2014
    ....
  20. doi request reprint Sensitive immunohistochemical detection of WT1 protein in tumors with anti-WT1 antibody against WT1 235 peptide
    Ryo Ichinohasama
    Division of Hematopathology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Cancer Sci 101:1089-92. 2010
    ....
  21. ncbi request reprint Interlaboratory comparison of quantitative RT-PCR based detection for minimal residual disease in leukemias: a standardization approach in Japan
    Minami F Yamada
    Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Tohoku J Exp Med 214:97-104. 2008
    ....
  22. ncbi request reprint Insufficient duration of action of antihypertensive drugs mediates high blood pressure in the morning in hypertensive population: the Ohasama study
    Kenichi Chonan
    Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Science and Medicine, Sendai, Japan
    Clin Exp Hypertens 24:261-75. 2002
    ..The high morning BP accompanies so-called non-dipper pattern of circadian BP variation. An insufficient duration of action of drugs may partly mediate non-dipping in subjects with antihypertensive medication...
  23. pmc Clinical and genetic characteristics of congenital sideroblastic anemia: comparison with myelodysplastic syndrome with ring sideroblast (MDS-RS)
    Rie Ohba
    Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai, 980 8574, Japan
    Ann Hematol 92:1-9. 2013
    ..Together with the difference of clinical data, it is suggested that genetic background, which is responsible for the development of CSA, is different from that of MDS-RS...
  24. ncbi request reprint Differential gene expression profiling between wild-type and ALAS2-null erythroblasts: identification of novel heme-regulated genes
    Tohru Fujiwara
    Department of Rheumatology and Hematology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Biochem Biophys Res Commun 340:105-10. 2006
    ..These findings thus suggest that heme may regulate a wide variety of hitherto unrecognized genes, and further analysis of these genes may clarify their role in erythroid cell differentiation...
  25. ncbi request reprint Study design of HOMED-BP: hypertension objective treatment based on measurement by electrical devices of blood pressure
    Tohru Fujiwara
    Department of Clinical Pharmacology and Therapeutics, and Public Health, Tohoku University School of Medicine and Pharmaceutical Science, Sendai, Japan
    Clin Exp Hypertens 25:143-4. 2003
    ..However, no large-scale interventional trial has been conducted to show which of these three initial medication can give the greatest benefit in terms of reduced cardiovascular disease risk in the Japanese hypertensive patients...
  26. ncbi request reprint T+31C polymorphism of angiotensinogen gene and nocturnal blood pressure decline: the Ohasama study
    Tohru Fujiwara
    Department of Clinical Pharmacology, Tohoku University Graduate School of Pharmaceutical Science and Medicine, Sendai, Japan
    Am J Hypertens 15:628-32. 2002
    ..We assessed the association between several polymorphisms of angiotensinogen gene (AGT) and essential hypertension using ambulatory blood pressure (BP)...
  27. doi request reprint Pathophysiology and genetic mutations in congenital sideroblastic anemia
    Tohru Fujiwara
    Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan Molecular Hematology Oncology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Pediatr Int 55:675-9. 2013
    ..This review will cover the findings of this recent survey and summarize the current understanding of the pathophysiology and genetic mutations involved in CSA. ..
  28. ncbi request reprint Angiotensin-converting enzyme I/D polymorphism and hypertension: the Ohasama study
    Mitsunobu Matsubara
    Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Medicine and Pharmaceutical Science, Sendai, Japan
    J Hypertens 20:1121-6. 2002
    ....
  29. ncbi request reprint Genotypes of the betaENaC gene have little influence on blood pressure level in the Japanese population
    Mitsunobu Matsubara
    Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Medicine and Pharmaceutical Science, Sendai, Japan
    Am J Hypertens 15:189-92. 2002
    ..These results indicate that Japanese people possess three polymorphisms in exon 12, all of which are unique, and one in exon 8. These genetic variants of betaENaC may not influence the BP level of Japanese people...
  30. ncbi request reprint Rationale and design of HOMED-BP Study: hypertension objective treatment based on measurement by electrical devices of blood pressure study
    Tohru Fujiwara
    Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharamaceutical Science and Medicine, Sendia, Japan
    Blood Press Monit 7:77-82. 2002
    ..However, no large-scale interventional trial has been conducted to show which of these three initial medications can give the greatest benefit in reducing the risk of cardiovascular disease in the Japanese hypertensive patient...