H Asao

Summary

Affiliation: Tohoku University
Country: Japan

Publications

  1. ncbi Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex
    H Asao
    Department of Microbiology and Immunology, Tohoku University Graduate School of Medicine, Sendai, Japan
    J Immunol 167:1-5. 2001
  2. ncbi STAM, signal transducing adaptor molecule, is associated with Janus kinases and involved in signaling for cell growth and c-myc induction
    T Takeshita
    Department of Microbiology, Tohoku University School of Medicine, Sendai, Japan
    Immunity 6:449-57. 1997
  3. ncbi Hrs is associated with STAM, a signal-transducing adaptor molecule. Its suppressive effect on cytokine-induced cell growth
    H Asao
    Department of Microbiology and Immunology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 77, Japan
    J Biol Chem 272:32785-91. 1997
  4. ncbi Possible involvement of a novel STAM-associated molecule "AMSH" in intracellular signal transduction mediated by cytokines
    N Tanaka
    Department of Microbiology and Immunology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    J Biol Chem 274:19129-35. 1999
  5. ncbi Loss of neurons in the hippocampus and cerebral cortex of AMSH-deficient mice
    N Ishii
    Department of Microbiology and Immunology, Tohoku University Graduate School of Medicine, Aoba ku, Sendai 980 8575, Japan
    Mol Cell Biol 21:8626-37. 2001
  6. ncbi Dispensability of Jak1 tyrosine kinase for interleukin-2-induced cell growth signaling in a human T cell line
    M Higuchi
    Department of Microbiology, Tohoku University School of Medicine, Sendai, Japan
    Eur J Immunol 26:1322-7. 1996
  7. ncbi Suppression of thymic development by the dominant-negative form of Gads
    K Kikuchi
    Department of Microbiology and Immunology, and The Institute for Animal Experimentation, Tohoku University Graduate School of Medicine, Sendai 980 8575, Japan
    Int Immunol 13:777-83. 2001
  8. ncbi Hgs (Hrs), a FYVE domain protein, is involved in Smad signaling through cooperation with SARA
    S Miura
    Department of Microbiology and Immunology, Tohoku University School of Medicine, Aoba ku, Japan
    Mol Cell Biol 20:9346-55. 2000
  9. ncbi A novel human tyrosine kinase gene inducible in T cells by interleukin 2
    N Tanaka
    Department of Microbiology, Tohoku University School of Medicine, Sendai, Japan
    FEBS Lett 324:1-5. 1993
  10. ncbi Cloning of the mouse interleukin 2 receptor gamma chain: demonstration of functional differences between the mouse and human receptors
    S Kumaki
    Department of Microbiology, Tohoku University School of Medicine, Sendai, Japan
    Biochem Biophys Res Commun 193:356-63. 1993

Collaborators

Detail Information

Publications16

  1. ncbi Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex
    H Asao
    Department of Microbiology and Immunology, Tohoku University Graduate School of Medicine, Sendai, Japan
    J Immunol 167:1-5. 2001
    ..The chemical cross-linking study reveals the direct binding of IL-21 to the gamma(c). These data clearly demonstrate that the gamma(c) is an indispensable subunit of the functional IL-21R complex...
  2. ncbi STAM, signal transducing adaptor molecule, is associated with Janus kinases and involved in signaling for cell growth and c-myc induction
    T Takeshita
    Department of Microbiology, Tohoku University School of Medicine, Sendai, Japan
    Immunity 6:449-57. 1997
    ..These results strongly implicate STAM in the signaling pathways for cell growth and c-myc induction immediately downstream of the Jaks associated with the cytokine receptors...
  3. ncbi Hrs is associated with STAM, a signal-transducing adaptor molecule. Its suppressive effect on cytokine-induced cell growth
    H Asao
    Department of Microbiology and Immunology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 77, Japan
    J Biol Chem 272:32785-91. 1997
    ..These results suggest that Hrs counteracts the STAM function which is critical for cell growth signaling mediated by the cytokines...
  4. ncbi Possible involvement of a novel STAM-associated molecule "AMSH" in intracellular signal transduction mediated by cytokines
    N Tanaka
    Department of Microbiology and Immunology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    J Biol Chem 274:19129-35. 1999
    ..These results suggest that AMSH plays a critical role in the cytokine-mediated intracellular signal transduction downstream of the Jak2/Jak3.STAM complex...
  5. ncbi Loss of neurons in the hippocampus and cerebral cortex of AMSH-deficient mice
    N Ishii
    Department of Microbiology and Immunology, Tohoku University Graduate School of Medicine, Aoba ku, Sendai 980 8575, Japan
    Mol Cell Biol 21:8626-37. 2001
    ..Taken together, these observations indicate that AMSH is an essential molecule for the survival of neuronal cells in early postnatal mice...
  6. ncbi Dispensability of Jak1 tyrosine kinase for interleukin-2-induced cell growth signaling in a human T cell line
    M Higuchi
    Department of Microbiology, Tohoku University School of Medicine, Sendai, Japan
    Eur J Immunol 26:1322-7. 1996
    ....
  7. ncbi Suppression of thymic development by the dominant-negative form of Gads
    K Kikuchi
    Department of Microbiology and Immunology, and The Institute for Animal Experimentation, Tohoku University Graduate School of Medicine, Sendai 980 8575, Japan
    Int Immunol 13:777-83. 2001
    ..Furthermore, the SLP-76-dependent signaling was markedly suppressed as well. These data suggest that Gads plays an important role in the pre-TCR as well as TCR signaling in thymocytes...
  8. ncbi Hgs (Hrs), a FYVE domain protein, is involved in Smad signaling through cooperation with SARA
    S Miura
    Department of Microbiology and Immunology, Tohoku University School of Medicine, Aoba ku, Japan
    Mol Cell Biol 20:9346-55. 2000
    ..5. Mutant cells showed significantly decreased responses to stimulation with activin and TGF-beta. These findings suggest that the two FYVE domain proteins, Hgs and SARA, are prerequisites for receptor-mediated activation of Smad2...
  9. ncbi A novel human tyrosine kinase gene inducible in T cells by interleukin 2
    N Tanaka
    Department of Microbiology, Tohoku University School of Medicine, Sendai, Japan
    FEBS Lett 324:1-5. 1993
    ..This gene was transcriptionally induced in normal T cells by interleukin 2 stimulation. These results suggest the crucial roles of this gene in T cell proliferation and differentiation...
  10. ncbi Cloning of the mouse interleukin 2 receptor gamma chain: demonstration of functional differences between the mouse and human receptors
    S Kumaki
    Department of Microbiology, Tohoku University School of Medicine, Sendai, Japan
    Biochem Biophys Res Commun 193:356-63. 1993
    ..These results indicate that the mouse functional IL-2 receptor is a complex comprising three distinct subunits, alpha, beta and gamma chains, but the beta gamma heterodimer is not functional and different from the human heterodimer...
  11. ncbi Impairment of ligand binding and growth signaling of mutant IL-2 receptor gamma-chains in patients with X-linked severe combined immunodeficiency
    N Ishii
    Department of Microbiology, Tohoku University School of Medicine, Sendai, Japan
    J Immunol 153:1310-7. 1994
    ..These findings indicate that the gamma-chain gene mutations that accompany XSCID induce loss of the gamma-chain function, possibly resulting in stagnation of the differentiation and development of T cells...
  12. ncbi Cloning of a novel signal-transducing adaptor molecule containing an SH3 domain and ITAM
    T Takeshita
    Department of Microbiology, Tohoku University School of Medicine, Sendai, Japan
    Biochem Biophys Res Commun 225:1035-9. 1996
    ..STAM contains an SH3 (Src-homology 3) domain and the ITAM (immunoreceptor tyrosine-based activation motif), suggesting that STAM acts as an adaptor molecule involved in signal transducing pathways from the cytokine receptors...
  13. ncbi Cloning of the gamma chain of the human IL-2 receptor
    T Takeshita
    Department of Microbiology, Tohoku University School of Medicine, Sendai, Japan
    Science 257:379-82. 1992
    ..Thus, the gamma chain is an indispensable component of the functional IL-2R...
  14. ncbi Human parvovirus B19 induces cell cycle arrest at G(2) phase with accumulation of mitotic cyclins
    E Morita
    Department of Microbiology and Immunology, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan
    J Virol 75:7555-63. 2001
    ..The B19 virus-induced G(2)/M arrest may be the critical event in the damage of erythroid progenitor cells seen in patients with B19 virus infection...
  15. ncbi STAM2, a new member of the STAM family, binding to the Janus kinases
    K Endo
    Department of Microbiology, Tohoku University School of Medicine, Seiryo machi 2 1, Aoba ku, Sendai 980 8575, Japan
    FEBS Lett 477:55-61. 2000
    ....
  16. ncbi Promoting bone morphogenetic protein signaling through negative regulation of inhibitory Smads
    F Itoh
    Division of Cellular Biochemistry, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands
    EMBO J 20:4132-42. 2001
    ..The data strongly suggest that the molecular mechanism by which AMSH exerts its action is by inhibiting the binding of Smad6 to activated type I receptors or activated R-Smads...