Affiliation: Tohoku University
Kano K, Matsumoto H, Inoue A, Yukiura H, Kanai M, Chun J, et al
. Molecular mechanism of lysophosphatidic acid-induced hypertensive response. Sci Rep. 2019;9:2662 pubmed publisher
..Together, these results indicate that circulating LPA produced by ATX contributes to the elevation of blood pressure through multiple LPA receptors, mainly LPA4. ..
Kawana H, Kano K, Shindou H, Inoue A, Shimizu T, Aoki J. An accurate and versatile method for determining the acyl group-introducing position of lysophospholipid acyltransferases. Biochim Biophys Acta Mol Cell Biol Lipids. 2019;1864:1053-1060 pubmed publisher
..The present method for evaluating the positional specificity could also be used for biochemical characterization of other LPLATs. ..
Uwamizu A, Inoue A, Suzuki K, Okudaira M, Shuto A, Shinjo Y, et al
. Lysophosphatidylserine analogues differentially activate three LysoPS receptors. J Biochem. 2015;157:151-60 pubmed publisher
..These pharmacological tools will definitely help to identify the biological roles of these LysoPS receptors. ..
Aikawa S, Hashimoto T, Kano K, Aoki J. Lysophosphatidic acid as a lipid mediator with multiple biological actions. J Biochem. 2015;157:81-9 pubmed publisher
..In this review we will summarize recent advances in the studies of LPA production and its roles in both physiological and pathological conditions. ..
Yukiura H, Kano K, Kise R, Inoue A, Aoki J. LPP3 localizes LPA6 signalling to non-contact sites in endothelial cells. J Cell Sci. 2015;128:3871-7 pubmed publisher
..These results indicate that LPP3 regulates and localizes LPA signalling in endothelial cells, thereby stabilizing vessels through Notch signalling for proper vasculature. ..
Aikawa S, Kano K, Inoue A, Wang J, Saigusa D, Nagamatsu T, et al
. Autotaxin-lysophosphatidic acid-LPA3 signaling at the embryo-epithelial boundary controls decidualization pathways. EMBO J. 2017;36:2146-2160 pubmed publisher
..Our results indicate that ATX-LPA-LPA3 signaling at the embryo-epithelial boundary induces decidualization via the canonical HB-EGF and COX-2 pathways. ..
Shinjo Y, Makide K, Satoh K, Fukami F, Inoue A, Kano K, et al
. Lysophosphatidylserine suppresses IL-2 production in CD4 T cells through LPS3/GPR174. Biochem Biophys Res Commun. 2017;494:332-338 pubmed publisher
..The present study raised the possibility that LysoPS exerts its immunosuppressive roles by down-regulating IL-2 production through a LysoPS-LPS3 axis in T cells...
Aikawa S, Kano K, Inoue A, Aoki J. Proliferation of mouse endometrial stromal cells in culture is highly sensitive to lysophosphatidic acid signaling. Biochem Biophys Res Commun. 2017;484:202-208 pubmed publisher
..The present results show that LPA signaling has a critical role in the proliferation of ESCs, and that this role is possibly mediated redundantly by LPA1 and LPA3. ..