Setsuya Aiba

Summary

Affiliation: Tohoku University
Country: Japan

Publications

  1. ncbi Decreased IL-10 production by psoriatic peripheral blood mononuclear cells stimulated with streptococcal superantigen
    Setsuya Aiba
    Department of Dermatology, Tohoku University School of Medicine, Sendai, Japan
    Exp Dermatol 11:337-43. 2002
  2. ncbi Dendritic cells play a crucial role in innate immunity to simple chemicals
    S Aiba
    Department of Dermatology, Tohoku University School of Medicine, Aobaku, Sendai, Japan
    J Investig Dermatol Symp Proc 4:158-63. 1999
  3. ncbi Evaluation of the efficacy of antihistamines using human monocyte-derived dendritic cells stimulated with histamine
    Tomoyuki Ohtani
    Department of Dermatology, Tohoku Unviersity Graduate School of Medicine, Sendai, Japan
    J Am Acad Dermatol 49:234-42. 2003
  4. ncbi Dendritic cell activation induced by various stimuli, e.g. exposure to microorganisms, their products, cytokines, and simple chemicals as well as adhesion to extracellular matrix
    S Aiba
    Department of Dermatology, Tohoku University School of Medicine, Aobaku, Sendai, Japan
    J Dermatol Sci 20:1-13. 1998
  5. ncbi p38 Mitogen-activated protein kinase and extracellular signal-regulated kinases play distinct roles in the activation of dendritic cells by two representative haptens, NiCl2 and 2,4-dinitrochlorobenzene
    Setsuya Aiba
    Department of Dermatology, Tohoku University School of Medicine, Sendai, Japan
    J Invest Dermatol 120:390-9. 2003
  6. ncbi Dendritic cells differently respond to haptens and irritants by their production of cytokines and expression of co-stimulatory molecules
    S Aiba
    Department of Dermatology, Tohoku University School of Medicine, Aobaku, Japan
    Eur J Immunol 27:3031-8. 1997
  7. ncbi Alteration in the production of IL-10 and IL-12 and aberrant expression of CD23, CD83 and CD86 by monocytes or monocyte-derived dendritic cells from atopic dermatitis patients
    Setsuya Aiba
    Department of Dermatology, Tohoku University School of Medicine, Aobaku, Sendai, Japan
    Exp Dermatol 12:86-95. 2003
  8. ncbi Interleukin-3 in cooperation with transforming growth factor beta induces granulocyte macrophage colony stimulating factor independent differentiation of human CD34+ hematopoietic progenitor cells into dendritic cells with features of Langerhans cells
    Zia U A Mollah
    Department of Dermatology, Tohoku University School of Medicine, Sendai, Japan
    J Invest Dermatol 121:1397-401. 2003
  9. doi Oxidation of cell surface thiol groups by contact sensitizers triggers the maturation of dendritic cells
    Saori Kagatani
    Department of Dermatology, Tohoku University Graduate School of Medicine, Aoba ku, Sendai, Japan
    J Invest Dermatol 130:175-83. 2010
  10. ncbi Macrophage colony-stimulating factor in cooperation with transforming growth factor-beta1 induces the differentiation of CD34+ hematopoietic progenitor cells into Langerhans cells under serum-free conditions without granulocyte-macrophage colony-stimulati
    Zia U A Mollah
    Department of Dermatology, Tohoku University School of Medicine, Sendai 980 8574, Japan
    J Invest Dermatol 120:256-65. 2003

Detail Information

Publications126 found, 100 shown here

  1. ncbi Decreased IL-10 production by psoriatic peripheral blood mononuclear cells stimulated with streptococcal superantigen
    Setsuya Aiba
    Department of Dermatology, Tohoku University School of Medicine, Sendai, Japan
    Exp Dermatol 11:337-43. 2002
    ....
  2. ncbi Dendritic cells play a crucial role in innate immunity to simple chemicals
    S Aiba
    Department of Dermatology, Tohoku University School of Medicine, Aobaku, Sendai, Japan
    J Investig Dermatol Symp Proc 4:158-63. 1999
    ....
  3. ncbi Evaluation of the efficacy of antihistamines using human monocyte-derived dendritic cells stimulated with histamine
    Tomoyuki Ohtani
    Department of Dermatology, Tohoku Unviersity Graduate School of Medicine, Sendai, Japan
    J Am Acad Dermatol 49:234-42. 2003
    ..It has been reported that histamine induces CD86 expression and chemokine production in human immature monocyte-derived dendritic cells (MoDCs), which can be blocked by both H(1)- and H(2)-receptor antagonists...
  4. ncbi Dendritic cell activation induced by various stimuli, e.g. exposure to microorganisms, their products, cytokines, and simple chemicals as well as adhesion to extracellular matrix
    S Aiba
    Department of Dermatology, Tohoku University School of Medicine, Aobaku, Sendai, Japan
    J Dermatol Sci 20:1-13. 1998
    ..In this paper, we discuss what kinds of stimuli effectively activate DCs...
  5. ncbi p38 Mitogen-activated protein kinase and extracellular signal-regulated kinases play distinct roles in the activation of dendritic cells by two representative haptens, NiCl2 and 2,4-dinitrochlorobenzene
    Setsuya Aiba
    Department of Dermatology, Tohoku University School of Medicine, Sendai, Japan
    J Invest Dermatol 120:390-9. 2003
    ..These data indicate that NiCl2 and 2,4-dinitrochlorobenzene stimulate different signal transduction pathways in monocyte-derived dendritic cells, and subsequently induce different phenotypic and functional changes in them...
  6. ncbi Dendritic cells differently respond to haptens and irritants by their production of cytokines and expression of co-stimulatory molecules
    S Aiba
    Department of Dermatology, Tohoku University School of Medicine, Aobaku, Japan
    Eur J Immunol 27:3031-8. 1997
    ..They also suggest that these chemicals stimulate DC by different mechanisms. By these responses, DC may modulate the final immune response to chemicals...
  7. ncbi Alteration in the production of IL-10 and IL-12 and aberrant expression of CD23, CD83 and CD86 by monocytes or monocyte-derived dendritic cells from atopic dermatitis patients
    Setsuya Aiba
    Department of Dermatology, Tohoku University School of Medicine, Aobaku, Sendai, Japan
    Exp Dermatol 12:86-95. 2003
    ....
  8. ncbi Interleukin-3 in cooperation with transforming growth factor beta induces granulocyte macrophage colony stimulating factor independent differentiation of human CD34+ hematopoietic progenitor cells into dendritic cells with features of Langerhans cells
    Zia U A Mollah
    Department of Dermatology, Tohoku University School of Medicine, Sendai, Japan
    J Invest Dermatol 121:1397-401. 2003
    ..These studies again demonstrated the ability of TGF-beta1 to polarize the differentiation of HPCs induced by IL-3 towards LC development, although IL-3 DCs were unable to form BGs partly because of their poor ability to induce Langerin...
  9. doi Oxidation of cell surface thiol groups by contact sensitizers triggers the maturation of dendritic cells
    Saori Kagatani
    Department of Dermatology, Tohoku University Graduate School of Medicine, Aoba ku, Sendai, Japan
    J Invest Dermatol 130:175-83. 2010
    ..These data suggest that the oxidation of cell surface thiols has some role in triggering DC maturation by sensitizers...
  10. ncbi Macrophage colony-stimulating factor in cooperation with transforming growth factor-beta1 induces the differentiation of CD34+ hematopoietic progenitor cells into Langerhans cells under serum-free conditions without granulocyte-macrophage colony-stimulati
    Zia U A Mollah
    Department of Dermatology, Tohoku University School of Medicine, Sendai 980 8574, Japan
    J Invest Dermatol 120:256-65. 2003
    ..In addition, the culture using macrophage colony-stimulating factor presents a novel culture system to enable a large-scale and long-term culture of immature Langerhans cells...
  11. ncbi p38 Mitogen-Activated protein kinase mediates dual role of ultraviolet B radiation in induction of maturation and apoptosis of monocyte-derived dendritic cells
    Satoshi Nakagawa
    Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan
    J Invest Dermatol 123:361-70. 2004
    ..Thus, our study revealed a dual effect of UVB, to stimulate maturation or to induce apoptosis in MoDC, depending on the dosage, via p38 MAPK pathway...
  12. pmc TGF-beta1 dampens the susceptibility of dendritic cells to environmental stimulation, leading to the requirement for danger signals for activation
    Tomoyuki Ohtani
    Department of Dermatology, Tohoku University Graduate School of Medicine, Seiryo machi, Aobaku, Sendai, Japan
    Immunology 126:485-99. 2009
    ..These data may suggest that TGF-beta1 protects LCs from being overactivated by harmless environmental stimulation, while maintaining their ability to become activated in response to danger signals released by keratinocytes...
  13. ncbi Sex steroid synthesis in human skin in situ: the roles of aromatase and steroidogenic acute regulatory protein in the homeostasis of human skin
    Takayoshi Inoue
    Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Mol Cell Endocrinol 362:19-28. 2012
    ....
  14. ncbi Accelerated antigen presentation and elicitation of humoral response in vivo by FcgammaRIIB- and FcgammaRI/III-mediated immune complex uptake
    Ayumi Yada
    Department of Experimental Immunology and the CREST Program of Japan Science and Technology Corporation, Institute of Development, Aging and Cancer, Tohoku University, 980 8575, Sendai, Japan
    Cell Immunol 225:21-32. 2003
    ..These results support the therapeutic benefits of antigen-targeting to FcgammaR on APC in the various inflammatory disorders...
  15. doi Molecular events in human T cells treated with diesel exhaust particles or formaldehyde that underlie their diminished interferon-gamma and interleukin-10 production
    Yoshinori Sasaki
    Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Int Arch Allergy Immunol 148:239-50. 2009
    ..A series of epidemiological and experimental studies have suggested that diesel exhaust particles (DEP) and formaldehyde (FA) may help trigger T helper type 2 (Th2)-mediated allergic responses...
  16. ncbi Acute cutaneous barrier disruption activates epidermal p44/42 and p38 mitogen-activated protein kinases in human and hairless guinea pig skin
    Hiromi Kobayashi
    Department of Dermatology, Tohoku University School of Medicine, Sendai, Japan
    Exp Dermatol 12:734-46. 2003
    ..These results for strongly suggest that the activation of p44/42 and p38 MAPKs links the stimuli of barrier disruption to the subsequent homeostatic responses to repair the barrier defect...
  17. ncbi Development of a novel Ag-specific immunotherapy using CpG oligodeoxynucleotides in a new, unique mouse cutaneous eosinophilic inflammation model
    Tanawatt Kootiratrakarn
    Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Eur J Immunol 35:3277-86. 2005
    ..The presented results provide strong evidence for the feasibility of a novel Ag-specific immunomodulator to treat cutaneous eosinophilic inflammation such as that characteristically found in patients with severe AD...
  18. ncbi Cadexomer as well as cadexomer iodine induces the production of proinflammatory cytokines and vascular endothelial growth factor by human macrophages
    Tomoyuki Ohtani
    Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Exp Dermatol 16:318-23. 2007
    ..These data suggest that cadexomer and cadexomer iodine have beneficial effects on wound healing in addition to those related to their antibacterial activity...
  19. ncbi Redox imbalance induced by contact sensitizers triggers the maturation of dendritic cells
    Masato Mizuashi
    Department of Dermatology, Tohoku University School of Medicine, Aobaku, Sendai, Japan
    J Invest Dermatol 124:579-86. 2005
    ..These data suggest that the GSH/GSSG imbalance plays a crucial role in triggering DC maturation by sensitizers...
  20. pmc Immunomodulatory effect of bisphosphonate risedronate sodium on CD163+ arginase 1+ M2 macrophages: the development of a possible supportive therapy for angiosarcoma
    Taku Fujimura
    Department of Dermatology, Tohoku University Graduate School of Medicine, Seiryo machi 1 1, Aoba ku, Sendai 980 8574, Japan
    Clin Dev Immunol 2013:325412. 2013
    ..Our present report suggests one of the possible mechanisms of DTX with RS in the supportive therapy for angiosarcoma. ..
  21. ncbi Cellular basis of the role of diesel exhaust particles in inducing Th2-dominant response
    Tomoyuki Ohtani
    Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan
    J Immunol 174:2412-9. 2005
    ..These data revealed a unique characteristic of DEP, namely that they induce a Th2 cytokine milieu in both T cells and dendritic cells...
  22. doi Dual oxidase 1 induced by Th2 cytokines promotes STAT6 phosphorylation via oxidative inactivation of protein tyrosine phosphatase 1B in human epidermal keratinocytes
    Satoshi Hirakawa
    Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai 980 8574, Japan
    J Immunol 186:4762-70. 2011
    ..These results revealed a novel role of IL-4/IL-13-induced DUOX1 expression in making a positive feedback loop for IL-4/IL-13 signaling in keratinocytes...
  23. ncbi Comparison of immunosuppressive and cytotoxic cells in angiosarcoma: development of a possible supportive therapy for angiosarcoma
    Yumi Kambayashi
    Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Dermatology 227:14-20. 2013
    ..These findings suggest that a high number of immunosuppressive cells might be related to the prognosis of AS, and that a combination of docetaxel with bisphosphonate risedronate sodium might be effective for MMP-9-expressing AS...
  24. doi In vivo imaging demonstrates ATP release from murine keratinocytes and its involvement in cutaneous inflammation after tape stripping
    Toshiya Takahashi
    Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan
    J Invest Dermatol 133:2407-15. 2013
    ..These results suggest that tape stripping prompts ATP release from viable keratinocytes, which facilitates inflammatory cell migration. Eluc-agarose may be useful in the in vivo detection of eATP in murine models of skin diseases. ..
  25. ncbi H1 and H2 histamine receptors are absent on Langerhans cells and present on dermal dendritic cells
    Tomoyuki Ohtani
    Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan
    J Invest Dermatol 121:1073-9. 2003
    ..These data suggest that LC do not express either H1 or H2 receptors, mainly because of the effect of TGF-beta1. This made a striking contrast with the expression of the functional H1 and H2 receptors on MoDC and dermal dendritic cells...
  26. ncbi Functional expression of heme oxygenase-1 in human differentiated epidermis and its regulation by cytokines
    Ikuko Numata
    Department of Dermatology, Tohoku University Graduate School of Medicine, Aobaku, Sendai, Japan
    J Invest Dermatol 129:2594-603. 2009
    ..These studies demonstrate that HO-1 is functionally expressed by keratinocytes in parallel with epidermal differentiation and that its expression is independently affected by several cytokines...
  27. doi Epidermal FABP (FABP5) regulates keratinocyte differentiation by 13(S)-HODE-mediated activation of the NF-κB signaling pathway
    Eisaku Ogawa
    Department of Dermatology, Shinshu University School of Medicine, Matsumoto, Japan
    J Invest Dermatol 131:604-12. 2011
    ..The regulation of fatty acid metabolism by E-FABP during keratinocyte differentiation suggests that E-FABP may have a role in the pathogenesis of psoriasis...
  28. doi A synthetic NOD2 agonist, muramyl dipeptide (MDP)-Lys (L18) and IFN-β synergistically induce dendritic cell maturation with augmented IL-12 production and suppress melanoma growth
    Taku Fujimura
    Department of Dermatology, Tohoku University Graduate School of Medicine, Seiryo machi 1 1, Aoba ku, Sendai 980 8574, Japan
    J Dermatol Sci 62:107-15. 2011
    ..A synthetic NOD2 agonist, muramyl dipeptide (MDP)-Lys (L18), mimics the bacterial peptidoglycan moiety and acts as a powerful adjuvant that induces cell-mediated immunity...
  29. ncbi Cord blood CD34+ cells differentiate into dermal dendritic cells in co-culture with cutaneous fibroblasts or stromal cells
    Zia U A Mollah
    Department of Dermatology, Tohoku University School of Medicine, Sendai, Japan
    J Invest Dermatol 118:450-60. 2002
    ....
  30. ncbi IL-28 elicits antitumor responses against murine fibrosarcoma
    Muneo Numasaki
    Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, Sendai, Japan
    J Immunol 178:5086-98. 2007
    ..Moreover, IL-12 augmented IL-28-mediated antitumor activity in the presence or absence of IFN-gamma. These findings indicate that IL-28 has bioactivities that induce innate and adaptive immune responses against tumors...
  31. pmc Bach1-dependent and -independent regulation of heme oxygenase-1 in keratinocytes
    Shuko Okada
    Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai 980 8574, Japan
    J Biol Chem 285:23581-9. 2010
    ..However, Bach1-mediated repression is negated during keratinocyte differentiation...
  32. ncbi CCR4 Expression by atypical T cells in systemic pilotropic lymphoma: its behavior under treatment with interferon gamma, topical PUVA and systemic retinoid
    Taku Fujimura
    Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Dermatology 208:221-6. 2004
    ..However, about 1 week after we discontinued this treatment because of the side effects, the lymph node swelling became prominent, and, 4 weeks later, the patient died before restarting any specific chemotherapy...
  33. ncbi Interferon-alpha is effective for CD4(+), CCR4(-) mycosis fungoides
    Taku Fujimura
    Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Int J Dermatol 46:435-8. 2007
    ..Although MF usually displays a Th2 profile, the tumor cells in our two cases did not express CCR4. Our cases suggest the effectiveness of IFN-alpha, but not IFN-gamma, for CCR4- MF...
  34. ncbi Sweat constitutes several natural moisturizing factors, lactate, urea, sodium, and potassium
    Akiko Watabe
    Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan
    J Dermatol Sci 72:177-82. 2013
    ..Recently, however, we have reported that lactate and potassium significantly affect the hydration state of SC...
  35. ncbi Successful treatment of syringotropic CD8+ mycosis fungoides accompanied by hypohidrosis with vorinostat and retinoids
    Aya Kakizaki
    Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Australas J Dermatol 54:e82-4. 2013
    ..Six months after treatment with this combination therapy, the patient's advanced MF was under control. ..
  36. doi Comparison of Foxp3+ regulatory T cells and CD163+ macrophages in invasive and non-invasive extramammary Paget's disease
    Taku Fujimura
    Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Acta Derm Venereol 92:625-8. 2012
    ..These findings suggest that the induction of immunosuppressive cells in extramammary Paget's disease differs according to the tumour stage...
  37. ncbi Generalized mucinosis in a patient with erythroderma
    Taku Fujimura
    Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Dermatology 212:366-9. 2006
    ..Both the erythroderma and generalized mucinosis responded to topical steroid and PUVA therapy. To the best of our knowledge, this is the first case of erythroderma accompanied by generalized mucinosis...
  38. ncbi Dendritic cells and contact dermatitis
    Yoshinori Sasaki
    Department of Dermatology, Graduate School of Medicine 1 1, Tohoku University, Seiryo machi, Sendai, Japan
    Clin Rev Allergy Immunol 33:27-34. 2007
    ..Based on these observations, we will discuss the biological significance of contact dermatitis. In addition, we will review some up-to-date findings on Langerhans cell biology...
  39. ncbi A comparison of the efficacy, relapse rate and side effects among three modalities of systemic corticosteroid therapy for alopecia areata
    Masahiro Kurosawa
    Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Dermatology 212:361-5. 2006
    ..Systemic corticosteroids are one of the most commonly used therapeutic modalities for patients with extensive alopecia areata (AA), although they entail several drawbacks...
  40. ncbi Inhibitory effect of the polyinosinic-polycytidylic acid/cationic liposome on the progression of murine B16F10 melanoma
    Taku Fujimura
    Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Eur J Immunol 36:3371-80. 2006
    ..These studies demonstrate the potential of peritumoral injection of PIC liposome as immunotherapy for malignant melanoma...
  41. ncbi Myxofibrosarcoma (myxoid malignant fibrous histiocytoma) showing cutaneous presentation: report of two cases
    Taku Fujimura
    Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan
    J Cutan Pathol 32:512-5. 2005
    ..Because the dermal presentation usually appears relatively banal, accurate diagnosis is sometimes challenging. In this report, we present two cases of myxofibrosarcoma with dermal involvement...
  42. doi Neuroselective transcutaneous electrical stimulation reveals neuronal sensitization in atopic dermatitis
    Maki Ozawa
    Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan
    J Am Acad Dermatol 60:609-14. 2009
    ..The neuroselective transcutaneous electrical stimulator (NTES) can provoke itch and/or pain by the application of a 5-Hz alternating current...
  43. pmc Simple chemicals can induce maturation and apoptosis of dendritic cells
    H Manome
    Department of Dermatology, Tohoku University School of Medicine, Aobaku, Sendai, Japan
    Immunology 98:481-90. 1999
    ....
  44. ncbi Comparison of interleukin-17- producing cells in different clinical types of alopecia areata
    Genichi Tojo
    Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Dermatology 227:78-82. 2013
    ..Among them, interestingly, the ratio of IL-17-producing cells in acute, diffuse and total alopecia was significantly lower than those of multiple types of AA. Our study sheds light on one of the possible immunological mechanisms of AA...
  45. pmc Potential use of bisphosphonates in invasive extramammary Paget's disease: an immunohistochemical Investigation
    Taku Fujimura
    Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai 980 8574, Japan
    Clin Dev Immunol 2013:164982. 2013
    ..In this study, we employed immunohistochemical staining for immunosuppressive macrophages and cytotoxic T cells in the lesional skin of patients with noninvasive EMPD and those with invasive EMPD...
  46. pmc Cutaneous squamous cell carcinoma developing from recessive dystrophic epidermolysis bullosa: a case report and an immunohistochemical study
    Akira Tsukada
    Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Case Rep Dermatol 4:197-201. 2012
    ....
  47. ncbi Comparison of the distribution and numbers of antigen-presenting cells among T-lymphocyte-mediated dermatoses: CD1a+, factor XIIIa+, and CD68+ cells in eczematous dermatitis, psoriasis, lichen planus and graft-versus-host disease
    Masatoshi Deguchi
    Department of Dermatology, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    Arch Dermatol Res 294:297-302. 2002
    ..The differences in the numbers of APCs in lesional skin appeared to reflect differences in the pathophysiology of these inflammatory skin diseases...
  48. ncbi Notch signaling: its role in epidermal homeostasis and in the pathogenesis of skin diseases
    Ryuhei Okuyama
    Department of Dermatology, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    J Dermatol Sci 49:187-94. 2008
    ..Future efforts to further define how Notch controls cell proliferation and differentiation may lead to the application of Notch in new therapies for various skin diseases...
  49. pmc p63/p51-induced onset of keratinocyte differentiation via the c-Jun N-terminal kinase pathway is counteracted by keratinocyte growth factor
    Eisaku Ogawa
    Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan
    J Biol Chem 283:34241-9. 2008
    ..These data may provide mechanistic explanations for the pathological features of skin diseases, including psoriasis...
  50. ncbi Decreased keratinocyte motility in skin wound on mice lacking the epidermal fatty acid binding protein gene
    Yoshiyuki Kusakari
    Department of Dermatology, Tohoku University Graduate School of Medicine, Tohoku, Japan
    Mol Cell Biochem 284:183-8. 2006
    ..Our analyses suggest that the E-FABP elevation may be necessary for the activation of cell motility within regenerative epidermis during wound healing...
  51. ncbi Strong expression of CD40, CD54 and HLA-DR antigen and lack of evidence for direct cellular cytotoxicity are unique immunohistopathological features in alopecia areata
    Maki Sato-Kawamura
    Department of Dermatology, Tohoku University School of Medicine, l l Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    Arch Dermatol Res 294:536-43. 2003
    ..These findings suggest that infiltrating T cells interact with perifollicular or follicular antigen-presenting cells to produce IFN-gamma, which deprives dermal papilla cells of their ability to maintain anagen hair growth...
  52. ncbi Comparison of immunosuppressive and immunomodulatory cells in keratoacanthoma and cutaneous squamous cell carcinoma
    Yumi Kambayashi
    Department of Dermatology, Tohoku University Graduate School of Medicine, Seiryo machi 1 1, Aoba ku, Sendai, 980 8574, Japan
    Acta Derm Venereol 93:663-8. 2013
    ..In addition, the expression of pSTAT1 on tumour cells was observed only in KA. These findings suggest that the induction of immunosuppressive and immunomodulatory cells differs between KA and SCC. ..
  53. doi Pigmented Necrobiosis Lipoidica Accompanied by Insulin-dependent Diabetes Mellitus Induces CD163 Proinflammatory Macrophages and Interleukin-17-producing Cells
    Chihiro Wakusawa
    Department of Dermatology, Tohoku University, Graduate School of Medicine, Seiryo machi 1 1, Aobaku, Sendai, 980 8574, Japan
    Acta Derm Venereol 93:475-6. 2013
    ..Abstract is missing (Letter). ..
  54. doi Functional melanocytes are readily reprogrammable from multilineage-differentiating stress-enduring (muse) cells, distinct stem cells in human fibroblasts
    Kenichiro Tsuchiyama
    1 Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan 2 Department of Stem Cell Biology and Histology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
    J Invest Dermatol 133:2425-35. 2013
    ..This technique may be applicable to the efficient production of melanocytes from accessible human fibroblasts by using Muse cells, thereby contributing to autologous transplantation for melanocyte dysfunctions, such as vitiligo. ..
  55. doi An in vitro test to screen skin sensitizers using a stable THP-1-derived IL-8 reporter cell line, THP-G8
    Toshiya Takahashi
    Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Miyagi 980 8574, Japan
    Toxicol Sci 124:359-69. 2011
    ..This newly developed assay is a candidate replacement for animal tests of skin sensitization because of its accuracy, convenience, and high throughput performance...
  56. pmc Successful Treatment of MMP-9-Expressing Angiosarcoma with Low-Dose Docetaxel and Bisphosphonate
    Masaya Ishibashi
    Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Case Rep Dermatol 4:5-9. 2012
    ..5 mg sodium risedronate hydrate. One and a half years after the standard treatment, there was no evidence of local recurrence or metastasis...
  57. doi Papuloerythroderma associated with monoclonal gammopathy of undetermined significance
    Taku Fujimura
    Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan
    J Dermatol 36:228-31. 2009
    ..His skin changes were improved, but the sharp gamma-globulin peak remained in the electrophoresis of serum protein. This case suggests an association between papuloerythroderma and MGUS...
  58. doi Increased hyaluronan production and decreased E-cadherin expression by cytokine-stimulated keratinocytes lead to spongiosis formation
    Tomoyuki Ohtani
    Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan
    J Invest Dermatol 129:1412-20. 2009
    ..These results suggest that the augmented production of HA and the decreased E-cadherin expression by keratinocytes stimulated with IL-4/IL-13 or IFN-gamma cause spongiosis in acute eczema...
  59. pmc Multiple low-grade fibromyxoid sarcoma on the upper arms with atypical histological presentation
    Sadanori Furudate
    Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Case Rep Dermatol 5:152-5. 2013
    ..Our case suggested that, regarding mesenchymal tumors with potential of malignancy in the skin, an initial wide excision is indispensable for complete remission of the tumor, even for low-grade malignancy such as LGFMS...
  60. pmc Successful treatment of plasmacytosis circumorificialis with topical tacrolimus: two case reports and an immunohistochemical study
    Taku Fujimura
    Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Case Rep Dermatol 5:79-83. 2013
    ....
  61. pmc Profiles of tumor-infiltrating lymphocytes in a case of trichilemmal carcinoma with spontaneous regression
    Sadanori Furudate
    Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Case Rep Dermatol 4:215-21. 2012
    ..Our present study describes some of the possible mechanisms of the self-regression of cutaneous malignant tumors and potential therapies for trichilemmal carcinoma by modifying the tumor microenvironment...
  62. pmc Basosquamous cell carcinoma developing from a renal transplantation recipient
    Akira Tsukada
    Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Case Rep Dermatol 4:227-32. 2012
    ..Our present study suggests some of the possible mechanisms for the carcinogenesis of cutaneous malignancy in RTRs...
  63. ncbi Ber-EP4 antigen is a marker for a cell population related to the secondary hair germ
    Maki Ozawa
    Department of Dermatology, Division of Internal Medicine, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    Exp Dermatol 13:401-5. 2004
    ....
  64. ncbi Pachydermodactyly in an elderly Japanese patient showing distal involvement of the fingers
    Ryuhei Okuyama
    Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Dermatology 213:177-8. 2006
  65. pmc Malignant fibrous histiocytoma with in-transit metastasis
    Taku Fujimura
    Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Case Rep Dermatol 3:164-9. 2011
    ..Since there is a great difference between the prognosis of MFH and atypical fibroxanthoma, precise diagnosis of the primary tumor is essential...
  66. ncbi Immunopathogenesis of psoriasis
    Maki Ozawa
    Department of Dermatology, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aobaku, Sendai, 980 8574, Japan
    Curr Drug Targets Inflamm Allergy 3:137-44. 2004
    ..Some of them have become target molecules for the treatment of psoriasis. And indeed, it has become possible now to treat patients with new, innovative drugs...
  67. ncbi Cytomegalovirus infection complicating immunosuppressive therapy for dermatomyositis
    Akira Hashimoto
    Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Acta Derm Venereol 86:535-7. 2006
    ..Our case reports demonstrate the importance of close monitoring of such patients and prompt initiation of appropriate therapy to manage a suspected CMV infection...
  68. doi Pigmented Epithelioid Melanocytoma: Immunohistochemical Profiles of Tumour-infiltrating Histiocytes
    Anna Sadayasu
    Department of Dermatology, Tohoku University Graduate School of Medicine, Seiryo machi 1 1, Aoba ku, Sendai, 980 8574, Japan
    Acta Derm Venereol 93:481-2. 2013
    ..Abstract is missing (Letter). ..
  69. pmc Successful treatment of adult-onset erythromelalgia with steroid pulse and pregabalin
    Aya Kakizaki
    Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Case Rep Dermatol 4:242-6. 2012
    ..Although the patient's pain gradually developed again, it could be controlled with pregabalin. Our present case might suggest a possible, optimal therapy for adult-onset EM...
  70. pmc Bullous Pemphigoid Accompanied by Aplastic Anemia: The Induction of IL-17-Producing Cells in the Affected Areas of the Skin
    Taku Fujimura
    Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Case Rep Dermatol 4:211-4. 2012
    ..Our findings might suggest relationships between IL-17 and the pathogenesis of these autoimmune diseases, and, to our knowledge, this is the first English report of BP accompanied by AA...
  71. doi Influences of p53 deficiency on the apoptotic response, DNA damage removal and mutagenesis in UVB-exposed mouse skin
    Hironobu Ikehata
    Department of Cell Biology, Tohoku University Graduate School of Medicine, Aoba ku, Sendai, Japan
    Mutagenesis 25:397-405. 2010
    ..These results indicate that p53 protects the skin genome from the UVB genotoxicity by facilitating NER, whereas its contribution to the UVB-induced apoptosis is limited...
  72. doi Nickel differentially regulates NFAT and NF-κB activation in T cell signaling
    Rumiko Saito
    Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai 980 8574, Japan
    Toxicol Appl Pharmacol 254:245-55. 2011
    ..These data showed that NiCl(2) decreases NFAT and increases NF-κB signaling in T cells. These results shed light on the effects of nickel on the molecular regulation of T cell signaling...
  73. doi Dermal melanocytosis of the helix
    Masato Mizuashi
    Department of Dermatology, Tohoku University School of Medicine, Sendai, Japan
    Pediatr Dermatol 27:305-6. 2010
    ..Q-switched alexandrite laser treatment induced a good cosmetic response. This patient shows the overlap between Ota and Ito nevi, and we suggest dermal melanocytosis is better used as a generic term for these unusual pigmentations...
  74. doi Erythema multiforme-like lesions associated with lesional infiltration of tumor cells occurring with adult T-cell lymphoma/leukemia
    Tomoyuki Ohtani
    Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Int J Dermatol 47:390-2. 2008
  75. ncbi Communication network in the follicular papilla and connective tissue sheath through gap junctions in human hair follicles
    Makiko Iguchi
    Department of Dermatology, Tohoku University School of Medicine, Sendai, Japan
    Exp Dermatol 12:283-8. 2003
    ..These findings suggest that the FP and the CTS form a communicating network through gap junctions, which may play a role in controlling the dynamic structural changes of hair follicles during hair cycling...
  76. ncbi Dendritic cells: importance in allergy
    Setsuya Aiba
    Department of Dermatology, Tohoku University Graduate School of Medicine, Miyagi, Japan
    Allergol Int 56:201-8. 2007
    ..The mechanisms by which DC induce the Th2-deviated immune response, namely via the Th2-deviated signal 3, are central topics in the pathogenesis of atopic disorders...
  77. pmc Synergistic effect of Nod1 and Nod2 agonists with toll-like receptor agonists on human dendritic cells to generate interleukin-12 and T helper type 1 cells
    Hiroyuki Tada
    Department of Microbiology and Immunology, Tohoku University Graduate School of Dentistry, 4 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Infect Immun 73:7967-76. 2005
    ..These findings suggest that Nod1 and Nod2 agonists in combination with TLR3, TLR4, and TLR9 agonists synergistically induce IL-12 and IFN-gamma production in DCs to induce Th1-lineage immune responses...
  78. ncbi Horizontal square buried sutures in a two-layered fashion enable direct primary closure for small circular wounds without dog-ears on the face
    Jun Matsunaga
    Department of Dermatology, Tohoku University Hospital, Aoba ku Sendai, Japan
    Dermatol Surg 31:574-6. 2005
    ..Dog-ears often lead to lengthening of an excision, and it is desirable to avoid them...
  79. ncbi Solitary subcutaneous mucinosis surrounded by bizarre-shaped, factor XIIIa-positive cells with intranuclear vacuoles
    T Terui
    Department of Dermatology, Tohoku University School of Medicine, Sendai, Japan
    J Cutan Pathol 25:271-4. 1998
    ..We think that this solitary subcutaneous mucinosis is a unique variant of cutaneous focal mucinosis, because neither a reticulin network nor reactivity to anti-smooth muscle A-actin antibody were demonstrable...
  80. ncbi Efficacy of early piston-type high-frequency oscillatory ventilation in infants with respiratory distress syndrome
    T Sakai
    Department of Pediatrics, Tohoku University School of Medicine, Sendai, Japan
    Pediatr Pulmonol 32:168-74. 2001
    ..These results suggest that initiating HFOV in combination with surfactant replacement therapy immediately after birth provides effective ventilatory support for infants with RDS...
  81. ncbi Paget's disease of the vulva: clinicopathologic study of type 1 cases treated at a single institution
    H Niikura
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Sendai 980 8574, Japan
    Int J Gynecol Cancer 16:1212-5. 2006
    ..Mapping biopsy with careful examination of characteristic skin surface may be useful for surgery of type 1a cases. Inguinal lymphadenectomy is recommended in cases with question of invasion or known underlying adenocarcinoma...
  82. doi Functional analyses of the skin surface of the areola mammae: comparison between healthy adult male and female subjects and between healthy individuals and patients with atopic dermatitis
    K Kikuchi
    Department of Dermatology, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    Br J Dermatol 164:97-102. 2011
    ..Although the nipple and areola of the breast constitute a unique and prominent area on the chest, so far no study has been done on the functional properties of their skin surfaces...
  83. ncbi Normal proliferative responses of peripheral blood mononuclear cells to streptococcal preparation OK-432 in patients with pustulosis palmaris et plantaris constitute a distinct feature from the reduced responses observed in those with psoriasis vulgaris,
    K Takahashi
    Department of Dermatology, Tohoku University School of Medicine, Seiryo machi 1 1, Aoba ku, 980 77, Sendai, Japan
    J Dermatol Sci 25:87-92. 2001
    ..These results, in addition to its unique clinical and histopathological characteristics, suggest that PPP has a different pathogenetic background from that underlying PV, AC, or GPP...
  84. ncbi Effects of mean and swing pressures on piston-type high-frequency oscillatory ventilation in rabbits with and without acute lung injury
    T Sakai
    Department of Pediatrics, Tohoku University School of Medicine, Sendai, Japan
    Pediatr Pulmonol 27:328-35. 1999
    ..Our findings suggest that physicians should use caution in reducing MAP during piston-type HFOV until lung compliance has normalized, especially in infants with respiratory distress syndrome...
  85. doi Pseudolymphomatous angiokeratoma: report of three cases and an immunohistological study
    R Okuyama
    Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Clin Exp Dermatol 34:161-5. 2009
    ....
  86. ncbi An increased ratio of interleukin-1 receptor antagonist to interleukin-1alpha in inflammatory skin diseases
    T Terui
    Department of Dermatology, Tohoku University School of Medicine, Sendai, Japan
    Exp Dermatol 7:327-34. 1998
    ....
  87. pmc Basal cell carcinoma with spontaneous regression: a case report and immunohistochemical study
    Taku Fujimura
    Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Case Rep Dermatol 4:125-32. 2012
    ..Our present study sheds light on the immunological mechanisms of tumor rejection in human BCC...
  88. pmc Successful treatment of granuloma faciale with topical tacrolimus: a case report and immunohistochemical study
    Gen Ichi Tojo
    Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Case Rep Dermatol 4:158-62. 2012
    ..In summary, the present data shed light on the granuloma-composing cells and possible mechanisms in the treatment of GF with topical tacrolimus...
  89. pmc Successful treatment of cutaneous botryomycosis with a combination of minocycline and topical heat therapy
    Masaya Ishibashi
    Department of Dermatology, Tohoku University Hospital, Sendai, Japan
    Case Rep Dermatol 4:114-8. 2012
    ..We employed topical heat therapy and oral minocycline. The lesions became flattened and pigmented after 1 month. We consider that this simple treatment can be an effective and harmless complementary therapy for cutaneous botryomycosis...
  90. pmc Pseudolymphomatous folliculitis on the nose
    Aya Kakizaki
    Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Case Rep Dermatol 4:27-30. 2012
    ..Though PLF typically behaves as benign lymphohyperplasia, differentiation from cutaneous lymphoma is necessary...
  91. ncbi The exudate of pressure ulcers contains a substantial amount of vascular endothelial growth factor
    Mariko Takayama
    Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Tohoku J Exp Med 221:315-9. 2010
    ..The presence of VEGF165 in the exudate of PUs inspires us to reconsider the treatment strategy of PUs that enhances the spontaneous healing...
  92. ncbi Neuroselective transcutaneous electric stimulation reveals body area-specific differences in itch perception
    Maki Ozawa
    Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan
    J Am Acad Dermatol 55:996-1002. 2006
    ..Electrically evoked itch has been reported, although the electrodes, the frequency, and the pulse duration used were not standardized...
  93. ncbi BRAF point mutations in primary melanoma show different prevalences by subtype
    Yoshinori Sasaki
    Department of Molecular Pathology, Tohoku University School of Medicine, Sendai, Japan
    J Invest Dermatol 123:177-83. 2004
    ..The BRAF mutation was observed frequently even in small lesions, indicating that activation of this gene may be one of the early events in the pathogenesis of some melanomas...
  94. ncbi Subcutaneous granuloma annulare in a child's palm: a case report
    Junji Takeyama
    Department of Pathology and Plastic Surgery, Miyagi Children s Hospital and the Department of Pathology, Tohoku University Hospital, Sendai, Japan
    J Hand Surg Am 31:103-6. 2006
    ..Subcutaneous granuloma annulare is a self-limited disease and treatment is not required, although recurrence and/or multiple lesions are frequent...
  95. ncbi Interferon-gamma and interleukin-10 inhibit antigen presentation by Langerhans cells for T helper type 1 cells by suppressing their CD80 (B7-1) expression
    H Ozawa
    Department of Dermatology, Tohoku University School of Medicine, Sendai, Japan
    Eur J Immunol 26:648-52. 1996
    ..The inhibitory effect of IFN-gamma on CD80 expression on LC appears to be partially mediated through the suppression of GM-CSF production by KC...
  96. ncbi Proliferative activity of CD8(+) T cells as an important clue to analyze T cell-mediated inflammatory dermatoses
    M Deguchi
    Department of Dermatology, Tohoku University School of Medicine, Sendai, Japan
    Arch Dermatol Res 293:442-7. 2001
    ..In conclusion, the proliferative status of T cells could be an important clue in the elucidation of the pathophysiology of T cell-mediated inflammatory dermatoses...
  97. doi Profiles of Foxp3+ regulatory T cells in eczematous dermatitis, psoriasis vulgaris and mycosis fungoides
    T Fujimura
    Department of Dermatology, Tohoku University Graduate School of Medicine, Seiryo machi 1 1, Aoba ku, Sendai 980 8574, Japan
    Br J Dermatol 158:1256-63. 2008
    ..Recently, it has been demonstrated that a Treg population resides in normal human skin. However, only a few studies have demonstrated the presence of Foxp3+ Tregs in inflammatory skin disorders...
  98. ncbi Cytokine mRNA profiles in cultured human skin component cells exposed to various chemicals: a simulation model of epicutaneous stimuli induced by skin barrier perturbation in comparison with that due to exposure to haptens or irritant
    A Terunuma
    Department of Dermatology, Tohoku University School of Medicine, 1-1 Seiryo-machi, Aoba-ku, 980-8574, Sendai, Japan
    J Dermatol Sci 26:85-93. 2001
    ..Our present data suggest that each skin component cell participates in inflammatory processes of the skin through its distinctive cytokine production profile when the skin barrier is compromized physically or chemically...
  99. ncbi Acute diffuse and total alopecia of the female scalp. A new subtype of diffuse alopecia areata that has a favorable prognosis
    Maki Sato-Kawamura
    Department of Dermatology, Tohoku University School of Medicine, Sendai, Japan
    Dermatology 205:367-73. 2002
    ..We examined 9 female patients who presented with acute, diffuse and total hair loss of the scalp and took a similar clinical course with a favorable prognosis...
  100. pmc Rapid Growth of Dermatofibrosarcoma Protuberans Associated with Bilateral Adrenalectomy for Cushing's Syndrome
    Sadanori Furudate
    Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Case Rep Dermatol 3:113-7. 2011
    ..To the best of our knowledge, this is the first case of rapid growth of DFSP that may be associated with bilateral adrenalectomy for Cushing's syndrome...
  101. doi The role of estrogen-metabolizing enzymes and estrogen receptors in human epidermis
    Takayoshi Inoue
    Department of Pathology, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, Miyagi 980 8575, Japan
    Mol Cell Endocrinol 344:35-40. 2011
    ..Our results suggest that age-related differences in aromatase and ERβ expressions impact epidermal homeostasis...