T Abe

Summary

Affiliation: Tohoku University
Country: Japan

Publications

  1. ncbi request reprint Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1
    T Abe
    Department of Neurophysiology, Tohoku University School of Medicine, Sendai, 980 8575, Tokyo, 140 8710, Japan
    J Biol Chem 274:17159-63. 1999
  2. ncbi request reprint LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers
    T Abe
    Division of Nephrology, Endocrinology, and Vascular Medicine, Department of Medicine, Tohoku University School of Medicine, Sendai, Japan
    Gastroenterology 120:1689-99. 2001
  3. ncbi request reprint Molecular characterization and tissue distribution of a new organic anion transporter subtype (oatp3) that transports thyroid hormones and taurocholate and comparison with oatp2
    T Abe
    Department of Neurophysiology, Tohoku University School of Medicine, Sendai 980 8575, Japan
    J Biol Chem 273:22395-401. 1998
  4. ncbi request reprint Thyroid hormone transporters: recent advances
    Takaaki Abe
    Division of Nephrology, Endocrinology and Vascular Medicine, Dept Medicine, Tohoku University Graduate School of Medicine and PRESTO, Japan Science and Technology Corporation JST, Japan
    Trends Endocrinol Metab 13:215-20. 2002
  5. ncbi request reprint Characterization of iris pigment epithelial cell for auto cell transplantation
    T Abe
    Department of Ophthalmology, Tohoku University, School of Medicine, Sendai, Miyagi, Japan
    Cell Transplant 8:501-10. 1999
  6. doi request reprint Daily total physical activity level and total cancer risk in men and women: results from a large-scale population-based cohort study in Japan
    Manami Inoue
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Am J Epidemiol 168:391-403. 2008
  7. ncbi request reprint Molecular identification of a rat novel organic anion transporter moat1, which transports prostaglandin D(2), leukotriene C(4), and taurocholate
    T Nishio
    Department of Neurophysiology, Tohoku University School of Medicine, Sendai, 980 8575, Japan
    Biochem Biophys Res Commun 275:831-8. 2000
  8. ncbi request reprint Anti-tumor activity of interleukin-2-producing tumor cells and recombinant interleukin 12 against mouse glioma cells located in the central nervous system
    T Kikuchi
    Institute of DNA Medicine, Department of Neurosurgery, Jikei University School of Medicine, Tokyo, Japan
    Int J Cancer 80:425-30. 1999
  9. doi request reprint Alcohol and risk of lung cancer among Japanese men: data from a large-scale population-based cohort study, the JPHC study
    Taichi Shimazu
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Cancer Causes Control 19:1095-102. 2008
  10. doi request reprint Body weight at age 20 years, subsequent weight change and breast cancer risk defined by estrogen and progesterone receptor status--the Japan public health center-based prospective study
    Reiko Suzuki
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Int J Cancer 129:1214-24. 2011

Collaborators

Detail Information

Publications127 found, 100 shown here

  1. ncbi request reprint Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1
    T Abe
    Department of Neurophysiology, Tohoku University School of Medicine, Sendai, 980 8575, Tokyo, 140 8710, Japan
    J Biol Chem 274:17159-63. 1999
    ..This is also the first report of the human molecule that transports thyroid hormones...
  2. ncbi request reprint LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers
    T Abe
    Division of Nephrology, Endocrinology, and Vascular Medicine, Department of Medicine, Tohoku University School of Medicine, Sendai, Japan
    Gastroenterology 120:1689-99. 2001
    ..The aim of this study was to isolate an organic anion transporter that is weak in normal cells, but abundantly expressed in cancer cells, to deliver the anticancer drugs to the cells...
  3. ncbi request reprint Molecular characterization and tissue distribution of a new organic anion transporter subtype (oatp3) that transports thyroid hormones and taurocholate and comparison with oatp2
    T Abe
    Department of Neurophysiology, Tohoku University School of Medicine, Sendai 980 8575, Japan
    J Biol Chem 273:22395-401. 1998
    ..This suggests that oatp2 and oatp3 are multifunctional transporters involved in the transport of thyroid hormones in the brain, retina, liver, and kidney...
  4. ncbi request reprint Thyroid hormone transporters: recent advances
    Takaaki Abe
    Division of Nephrology, Endocrinology and Vascular Medicine, Dept Medicine, Tohoku University Graduate School of Medicine and PRESTO, Japan Science and Technology Corporation JST, Japan
    Trends Endocrinol Metab 13:215-20. 2002
    ..Here, we discuss the classification of thyroid hormone transporters, with emphasis on how they are influenced by their ionic milieu and what their symported organic anions are...
  5. ncbi request reprint Characterization of iris pigment epithelial cell for auto cell transplantation
    T Abe
    Department of Ophthalmology, Tohoku University, School of Medicine, Sendai, Miyagi, Japan
    Cell Transplant 8:501-10. 1999
    ..In the present study, we established auto IPE cell culture using auto serum. The cultured IPE cell showed pigment epithelial cell properties until around five passages in both human and monkey...
  6. doi request reprint Daily total physical activity level and total cancer risk in men and women: results from a large-scale population-based cohort study in Japan
    Manami Inoue
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Am J Epidemiol 168:391-403. 2008
    ..By site, decreased risks were observed for cancers of the colon, liver, and pancreas in men and for cancer of the stomach in women. Increased daily physical activity may be beneficial in preventing cancer in a relatively lean population...
  7. ncbi request reprint Molecular identification of a rat novel organic anion transporter moat1, which transports prostaglandin D(2), leukotriene C(4), and taurocholate
    T Nishio
    Department of Neurophysiology, Tohoku University School of Medicine, Sendai, 980 8575, Japan
    Biochem Biophys Res Commun 275:831-8. 2000
    ....
  8. ncbi request reprint Anti-tumor activity of interleukin-2-producing tumor cells and recombinant interleukin 12 against mouse glioma cells located in the central nervous system
    T Kikuchi
    Institute of DNA Medicine, Department of Neurosurgery, Jikei University School of Medicine, Tokyo, Japan
    Int J Cancer 80:425-30. 1999
    ..In summary, the therapeutic potential for control of tumor growth by intratumoral administration of IL-2-producing glioma cells and rIL-12 may be useful in the development of treatment for patients with glioma...
  9. doi request reprint Alcohol and risk of lung cancer among Japanese men: data from a large-scale population-based cohort study, the JPHC study
    Taichi Shimazu
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Cancer Causes Control 19:1095-102. 2008
    ..Here, we investigated the association between alcohol consumption and lung cancer incidence...
  10. doi request reprint Body weight at age 20 years, subsequent weight change and breast cancer risk defined by estrogen and progesterone receptor status--the Japan public health center-based prospective study
    Reiko Suzuki
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Int J Cancer 129:1214-24. 2011
    ..50-3.34)]. Low BMI at age 20 years was substantially associated with an increased risk of breast cancer. In contrast, high recent BMI and subsequent BMI gain from age 20 were associated with increased risk of postmenopausal ER+PR+ tumors...
  11. doi request reprint Body mass index and subsequent risk of kidney cancer: a prospective cohort study in Japan
    Norie Sawada
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Ann Epidemiol 20:466-72. 2010
    ..Herein, we investigate the association between body mass index (BMI) and kidney cancer risk in Japanese persons, a relatively lean population...
  12. ncbi request reprint Cis-acting region associated with lung cell-specific expression of the secretory leukoprotease inhibitor gene
    T Kikuchi
    Department of Respiratory Oncology and Molecular Medicine, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    Am J Respir Cell Mol Biol 17:361-7. 1997
    ..These results suggest that the ratio of these two nuclear binding proteins confers the cell type specificity on the expression pattern of the SLPI gene...
  13. ncbi request reprint Antitumor activity of interleukin 12 against interleukin 2-transduced mouse glioma cells
    T Kikuchi
    The Institute of DNA Medicine, and Department of Neurosurgery, Jikei University, Tokyo, Japan
    Cancer Lett 135:47-51. 1999
    ..rmIL-12 or saline were then injected i.p. into mice that had been inoculated in the brain with SR/IL-2 cells. There was no significant difference in survival time between the treated and control groups...
  14. doi request reprint Leisure-time physical activity and breast cancer risk defined by estrogen and progesterone receptor status--the Japan Public Health Center-based Prospective Study
    Reiko Suzuki
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, 5 1 1 Tsukiji, Tokyo, 104 0045, Japan
    Prev Med 52:227-33. 2011
    ..The study aims to investigate the association between leisure-time physical activity and breast cancer risk in consideration of tumor estrogen-receptor/progesterone-receptor status...
  15. doi request reprint Female reproductive factors and the risk of gastric cancer in a large-scale population-based cohort study in Japan (JPHC study)
    Christina Persson
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Eur J Cancer Prev 17:345-53. 2008
    ..Although early estrogen exposure may have some protective effect, female reproductive factors may have no substantial influence on gastric cancer development...
  16. doi request reprint Coffee, green tea, and caffeine consumption and subsequent risk of bladder cancer in relation to smoking status: a prospective study in Japan
    Norie Kurahashi
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, 5 1 1 Tsukiji, Chuo Ku, Tokyo, Japan
    Cancer Sci 100:294-91. 2009
    ..15–3.66), respectively. In conclusion, cigarette smoking was confirmed as a risk factor for bladder cancer. Coffee and caffeine may be associated with an increased bladder cancer risk in never or former smokers among Japanese men...
  17. ncbi request reprint Impact of lifestyle on overall cancer risk among Japanese: the Japan Public Health Center-based Prospective Study (JPHC Study)
    Manami Inoue
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    J Epidemiol 20:90-6. 2010
    ..Although people with a history of diabetes may be at increased risk of cancer, extreme body mass index and metabolic factors in the aggregate had little impact on overall cancer risk in the Japanese population...
  18. ncbi request reprint Identification of thyroid hormone transporters in humans: different molecules are involved in a tissue-specific manner
    K Fujiwara
    Department of Neurophysiology, First Department of Surgery, Second Department of Internal Medicine, Tohoku University School of Medicine, Sendai 980 8575, Japan
    Endocrinology 142:2005-12. 2001
    ..5 microM), T(4) (K(m), 8.0 microM), and rT(3). These data suggest that in humans, several different molecules are involved in transporting thyroid hormone: OATP in the brain, LST-1 in the liver, and OATP-E in peripheral tissues...
  19. ncbi request reprint Functional analysis after auto iris pigment epithelial cell transplantation in patients with age-related macular degeneration
    T Abe
    Department of Ophthalmology, Tohoku University, School of Medicine, Sendai, Japan
    Tohoku J Exp Med 189:295-305. 1999
    ..From this functional analysis, transplanted autologous IPE may have, in part, an alternative function in regard to the retinal pigment epithelium in the subretinal space...
  20. doi request reprint Isoflavone consumption and subsequent risk of hepatocellular carcinoma in a population-based prospective cohort of Japanese men and women
    Norie Kurahashi
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Int J Cancer 124:1644-9. 2009
    ..Women with hepatitis virus infection may be advised to abstain from isoflavone consumption. Further studies are warranted to confirm these findings...
  21. doi request reprint Serum aminotransferase level and the risk of hepatocellular carcinoma: a population-based cohort study in Japan
    Seiji Ishiguro
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Eur J Cancer Prev 18:26-32. 2009
    ..This finding indicates that ALT level is a good independent determinant of the need for intervention. Clinical application of these findings may help decrease HCC-associated mortality in hepatitis virus-endemic regions...
  22. ncbi request reprint Molecular characterization and functional regulation of a novel rat liver-specific organic anion transporter rlst-1
    M Kakyo
    Department of Neurophysiology, Tohoku University School of Medicine, Sendai, Ltd, Tokyo, Japan
    Gastroenterology 117:770-5. 1999
    ..The aim of this study was to isolate a rat counterpart of human LST-1 and examine the expression regulation of its messenger RNA (mRNA) to clarify the molecular basis of cholestasis...
  23. ncbi request reprint A frequent 1085delC/insGAAG mutation in the RDH5 gene in Japanese patients with fundus albipunctatus
    Y Wada
    Department of Ophthalmology, Tohoku University School of Medicine, Sendai, Japan
    Invest Ophthalmol Vis Sci 41:1894-7. 2000
    ..To identify the frequency of a mutation of the RDH5 gene in Japanese patients with hereditary retinal degeneration and to characterize clinical findings for the patients associated with a 1085delC/insGAAG mutation in the RDH5 gene...
  24. doi request reprint Consumption of sodium and salted foods in relation to cancer and cardiovascular disease: the Japan Public Health Center-based Prospective Study
    Ribeka Takachi
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Am J Clin Nutr 91:456-64. 2010
    ....
  25. doi request reprint Fruits and vegetables in relation to prostate cancer in Japanese men: the Japan Public Health Center-Based Prospective Study
    Ribeka Takachi
    Division of Clinical Epidemiology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Nutr Cancer 62:30-9. 2010
    ..However, the possibility of confounding by detection bias on the risk of localized cancer could not be totally ruled out...
  26. doi request reprint Calcium, vitamin D and dairy intake in relation to type 2 diabetes risk in a Japanese cohort
    K Kirii
    Department of Epidemiology and International Health, Research Institute, International Medical Center of Japan, Tokyo, Japan
    Diabetologia 52:2542-50. 2009
    ..Calcium and vitamin D have been implicated in the development of type 2 diabetes, but epidemiological evidence is limited. We examined prospectively the relation of calcium and vitamin D intake to type 2 diabetes risk in a Japanese cohort...
  27. doi request reprint Coffee consumption and risk of endometrial cancer: a prospective study in Japan
    Taichi Shimazu
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Int J Cancer 123:2406-10. 2008
    ..Coffee consumption may be associated with a decreased risk of endometrial cancer...
  28. ncbi request reprint Rat kidney thromboxane synthase: cDNA cloning and gene expression regulation in hydronephrotic kidney
    E Tsutsumi
    Second Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan
    Prostaglandins 53:423-31. 1997
    ..In conclusion, we have revealed the structure of rat kidney TX synthase. Up-regulation of renal TX synthase, which may cause stimulation of TX synthesis, is possibly implicated in the tissue injury in hydronephrotic kidney...
  29. doi request reprint Reproductive factors, exogenous female hormone use and colorectal cancer risk: the Japan Public Health Center-based Prospective Study
    Munira Akhter
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Eur J Cancer Prev 17:515-24. 2008
    ..59). In contrast, no statistically significant association was found for rectal cancer. These findings suggest that late age at first birth is associated with a reduced risk of colon cancer in postmenopausal Japanese women...
  30. doi request reprint Impact of viral load of hepatitis C on the incidence of hepatocellular carcinoma: A population-based cohort study (JPHC Study)
    Seiji Ishiguro
    National Cancer Center, Tokyo, Japan
    Cancer Lett 300:173-9. 2011
    ..The risk was 3.86-fold higher (CI; 1.73-8.62) for genotype 1 than genotype 2. Our findings suggest that HCV viremia strongly influences the occurrence of hepatocellular carcinoma without titer-dependence...
  31. ncbi request reprint Human liver-specific organic anion transporter, LST-1, mediates uptake of pravastatin by human hepatocytes
    D Nakai
    Drug Metabolism and Pharmacokinetics Research Laboratories, Sankyo Co, Ltd, Tokyo, Japan
    J Pharmacol Exp Ther 297:861-7. 2001
    ..Therefore, LST-1 was regarded as a key molecule for pravastatin in liver-specific inhibition of cholesterol synthesis, making pravastatin accessible to the target enzyme, which would otherwise not be inhibited by this hydrophilic drug...
  32. doi request reprint Effect of alcohol consumption, cigarette smoking and flushing response on esophageal cancer risk: a population-based cohort study (JPHC study)
    Seiji Ishiguro
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Cancer Lett 275:240-6. 2009
    ..10-5.51). Strong effect modification was detected in heavy smokers. Our results suggest that heavy alcohol consumption together with heavy smoking may increase the risk of ESCC particularly in individuals with the flushing response...
  33. doi request reprint High dietary intake of magnesium may decrease risk of colorectal cancer in Japanese men
    Enbo Ma
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    J Nutr 140:779-85. 2010
    ..There were no significant associations between magnesium intake and cancer risk in women. Higher dietary intake of magnesium may decrease the risk of CRC in Japanese men...
  34. doi request reprint Validity of self-reported cancer among a Japanese population: recent results from a population-based prospective study in Japan (JPHC Study)
    Manami Inoue
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Cancer Epidemiol 35:250-3. 2011
    ..Self-reported diagnoses of cancer do not provide sufficient accuracy for the detection and classification of incident cancers. Our findings may be extrapolated to other Japanese populations...
  35. doi request reprint Alcohol consumption-associated breast cancer incidence and potential effect modifiers: the Japan Public Health Center-based Prospective Study
    Reiko Suzuki
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Chuo Ku, Tokyo, Japan
    Int J Cancer 127:685-95. 2010
    ..15). Excessive alcohol intake was associated with an increase in the risk of breast cancer in this population. There was no statistical evidence for effect modification...
  36. ncbi request reprint Auto iris pigment epithelial cell transplantation in patients with age-related macular degeneration: short-term results
    T Abe
    Department of Ophthalmology, Tohoku University, School of Medicine, Sendai, Japan
    Tohoku J Exp Med 191:7-20. 2000
    ..In conclusion, the treatment resulted in no significant improvement in macular function, as compared with the control; however, no rejection or deterioration in visual acuity occurred up to the 13 month follow up...
  37. doi request reprint Fruit and vegetable consumption and squamous cell carcinoma of the esophagus in Japan: the JPHC study
    Taiki Yamaji
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Int J Cancer 123:1935-40. 2008
    ..Finally, cruciferous vegetables deserve further investigation as foods possibly effective in the prevention of esophageal SCC...
  38. ncbi request reprint Mutation of human retinal fascin gene (FSCN2) causes autosomal dominant retinitis pigmentosa
    Y Wada
    Department of Ophthalmology, Tohoku University School of Medicine, Sendai, Japan
    Invest Ophthalmol Vis Sci 42:2395-400. 2001
    ..To characterize the clinical features of 14 Japanese patients with autosomal dominant retinitis pigmentosa (ADRP) who were found to have a mutation in the FSCN2 gene...
  39. doi request reprint Taste preferences and body weight change in Japanese adults: the JPHC Study
    Y Matsushita
    Department of Epidemiology and International Health, Research Institute, International Medical Center of Japan, Shinjuku ku, Tokyo, Japan
    Int J Obes (Lond) 33:1191-7. 2009
    ..Limited data are available with regard to longitudinal changes in body weight by food taste preference. Here, we examined the associations between taste preferences and weight change in adults for a large-scale cohort study in Japan...
  40. doi request reprint Plasma testosterone and sex hormone-binding globulin concentrations and the risk of prostate cancer among Japanese men: a nested case-control study
    Norie Sawada
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Cancer Sci 101:2652-7. 2010
    ..In conclusion, in this nested case-control study, concentrations of circulating total testosterone, free testosterone or SHBG were not strongly associated with a risk for total prostate cancer...
  41. ncbi request reprint Molecular cloning and intrarenal localization of rat prostaglandin E2 receptor EP3 subtype
    K Takeuchi
    Second Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan
    Biochem Biophys Res Commun 194:885-91. 1993
    ....
  42. doi request reprint Effect of coffee and green tea consumption on the risk of liver cancer: cohort analysis by hepatitis virus infection status
    Manami Inoue
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Cancer Epidemiol Biomarkers Prev 18:1746-53. 2009
    ..Our results suggest that coffee consumption may reduce the risk of liver cancer regardless of HCV and HBV infection status, whereas green tea may not reduce this risk..
  43. ncbi request reprint Increased expression of low-affinity NGF receptor in rat retinal Müller cells after ischemia and reperfusion
    H Tomita
    Department of Ophthalmology, Tohoku University School of Medicine, Sendai, Japan
    Cell Struct Funct 23:201-7. 1998
    ..The fact that p75LNGFR gene expression increased in Müller cells after reperfusion suggested that p75LNGFR expression may play a curative role in ischemic injury...
  44. ncbi request reprint A novel Gly35Ser mutation in the RDH5 gene in a Japanese family with fundus albipunctatus associated with cone dystrophy
    Y Wada
    Department of Ophthalmology, Tohoku University School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 77, Japan
    Arch Ophthalmol 119:1059-63. 2001
    ..To assess the clinical and genetic characteristics of a Japanese family with fundus albipunctatus with progressive cone dystrophy associated with a mutation in the RDH5 gene...
  45. ncbi request reprint Mottled gene expression and copper distribution in the macular mouse, an animal model for Menkes disease
    Y Murata
    Department of Pediatrics, Teikyo University School of Medicine, Tokyo, Japan
    J Inherit Metab Dis 21:199-202. 1998
  46. pmc Education level and physical functional limitations among Japanese community residents-gender difference in prognosis from stroke
    Kaori Honjo
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    BMC Public Health 9:131. 2009
    ..We sought to examine the association between education level and physical functional limitations among Japanese men and women, and whether that association was modified by gender and history of stroke...
  47. doi request reprint Intake of n-3 and n-6 polyunsaturated fatty acids and development of colorectal cancer by subsite: Japan Public Health Center-based prospective study
    Shizuka Sasazuki
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Int J Cancer 129:1718-29. 2011
    ..Our results suggest that intake of marine n-3 polyunsaturated fatty acids may be inversely related to the risk of cancer in the proximal site of the large bowel...
  48. ncbi request reprint Structure of the murine secretory leukoprotease inhibitor (Slpi) gene and chromosomal localization of the human and murine SLPI genes
    T Kikuchi
    Department of Respiratory Oncology and Molecular Medicine, Division of Cancer Control, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    Am J Respir Cell Mol Biol 19:875-80. 1998
    ..Using fluorescence in situ hybridization, we confirmed that, consistent with the genomic similarity, the human SLPI gene is localized on chromosome 20q12-13. 2 and the mouse homologue on chromosome 2H, which are syntenic with each other...
  49. doi request reprint Education in relation to incidence of and mortality from cancer and cardiovascular disease in Japan
    Shinichiro Ito
    Tohoku University School of Law, Sendai, Japan
    Eur J Public Health 18:466-72. 2008
    ..Although lower education has been associated with poorer health, few studies have examined whether lower education affects mortality, incidence, both or neither of cancer and cardiovascular disease...
  50. doi request reprint Dairy product, saturated fatty acid, and calcium intake and prostate cancer in a prospective cohort of Japanese men
    Norie Kurahashi
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Cancer Epidemiol Biomarkers Prev 17:930-7. 2008
    ..62 (1.15-2.29) and 1.53 (1.07-2.20), respectively. In conclusion, our results suggest that the intake of dairy products may be associated with an increased risk of prostate cancer...
  51. doi request reprint Plasma organochlorine levels and subsequent risk of breast cancer among Japanese women: a nested case-control study
    Motoki Iwasaki
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, 5 1 1 Tsukiji, Chuo Ku, Tokyo, 104 0045, Japan
    Sci Total Environ 402:176-83. 2008
    ..Our data do not support the hypothesis that plasma levels of p,p'-DDT, p,p'-DDE, HCB, and beta-HCH are associated with an overall increased risk of breast cancer among Japanese women...
  52. doi request reprint Daily total physical activity level and premature death in men and women: results from a large-scale population-based cohort study in Japan (JPHC study)
    Manami Inoue
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Ann Epidemiol 18:522-30. 2008
    ..We prospectively examined the association between daily total physical activity level (METs/day) and subsequent risk of all-cause mortality and mortalities from cancer, heart disease, and cerebrovascular disease...
  53. ncbi request reprint Purification and characterization of a 58,000-Da proteinase inhibitor from the hemolymph of a solitary ascidian, Halocynthia roretzi
    F Shishikura
    Department of Biology, Nihon University School of Medicine, Tokyo, Japan
    Comp Biochem Physiol B Biochem Mol Biol 114:1-9. 1996
    ..The inhibitory activity was not affected appreciably by pH 7-10 but ceased completely below pH 5 or by heating at 50 degrees C for 30 min...
  54. ncbi request reprint Mutation analysis and expression of the mottled gene in the macular mouse model of Menkes disease
    Y Murata
    Department of Pediatrics, Teikyo University School of Medicine, Tokyo, Japan
    Pediatr Res 42:436-42. 1997
    ..The distribution of expression of mottled is correlated with cells and tissues showing histopathology or abnormal copper sequestration in macular and other mutants...
  55. ncbi request reprint A novel (Pro79Thr) mutation in the FKHL7 gene in a Japanese family with Axenfeld-Rieger syndrome
    T Suzuki
    Department of Ophthalmology, Tohoku University School of Medicine, 1 1, Seiryo machi, Aoba ku, Sendai, Miyagi 980 8574, Japan
    Am J Ophthalmol 132:572-5. 2001
    ..To report the ocular and genetic findings of a Japanese family with Axenfeld-Rieger syndrome associated with a novel Pro79Thr mutation in the FKHL7 gene...
  56. ncbi request reprint Expression of the 37-kDa laminin binding protein in murine lung tumor cell correlates with tumor angiogenesis
    M Tanaka
    Department of Respiratory Oncology and Molecular Medicine, Institute of Development, Aging, and Cancer, Tohoku University, 4 1 Seiryo machi, Aoba ku, Sendai, Japan
    Cancer Lett 153:161-8. 2000
    ..These results suggest that decreased expression of 37LBP in antisense-RNA transfectant may relate to its low tumorigenicity, and that this effect may be partly caused by the diminished tumor angiogenesis of murine lung cancer...
  57. ncbi request reprint An improved sensitive assay method for the heterogeneity of alpha-foetoprotein: possible application for early differential diagnosis
    K Ohkawa
    Department of Biochemistry, Jikei University School of Medicine, Tokyo, Japan
    J Clin Chem Clin Biochem 27:337-41. 1989
    ....
  58. ncbi request reprint Simultaneous or delayed administration of hepatocyte growth factor equally represses the fibrotic changes in murine lung injury induced by bleomycin. A morphologic study
    M Yaekashiwa
    Department of Respiratory Oncology and Molecular Medicine, Tohoku University, Sendai, Japan
    Am J Respir Crit Care Med 156:1937-44. 1997
    ..HGF may be a potent candidate to prevent or treat lung fibrosis...
  59. ncbi request reprint Induction of antitumor immunity using intercellular adhesion molecule 1 (ICAM-1) transfection in mouse glioma cells
    T Kikuchi
    The Institute of DNA Medicine, Department of Neurosurgery, Jikei University School of Medicine, Tokyo, Japan
    Cancer Lett 142:201-6. 1999
    ..In this study, we demonstrated the therapeutic potential of vaccination with ICAM-1-overexpressing tumor cells for the control of the tumor growth...
  60. ncbi request reprint Results of a phase I clinical trial of vaccination of glioma patients with fusions of dendritic and glioma cells
    T Kikuchi
    Department of Oncology, The Institute of DNA Medicine, Jikei University, Tokyo, Japan
    Cancer Immunol Immunother 50:337-44. 2001
    ..we were unable to establish a statistically significant treatment-associated response rate, due to the limited sample population. Therefore, further evaluation of the role of adjuvant cytokines is necessary...
  61. doi request reprint Fish intake and type 2 diabetes in Japanese men and women: the Japan Public Health Center-based Prospective Study
    Akiko Nanri
    Department of Epidemiology and Prevention, International Clinical Research Center, National Center for Global Health and Medicine, Tokyo, Japan
    Am J Clin Nutr 94:884-91. 2011
    ..However, data from populations with high fish consumption are scarce...
  62. doi request reprint Overweight and obesity trends among Japanese adults: a 10-year follow-up of the JPHC Study
    Y Matsushita
    Department of Epidemiology and International Health, Research Institute, International Medical Center of Japan, Shinjuku ku, Tokyo, Japan
    Int J Obes (Lond) 32:1861-7. 2008
    ..Here, we describe changes in the prevalences of overweight and obesity and calculated the incidence of these indices during a 10-year follow-up period for a large-scale cohort study in Japan...
  63. ncbi request reprint Bacterial pneumonia causes augmented expression of the secretory leukoprotease inhibitor gene in the murine lung
    T Abe
    Department of Respiratory Oncology and Molecular Medicine, Tohoku University, Sendai, Japan
    Am J Respir Crit Care Med 156:1235-40. 1997
    ..These facts suggested the local regulation of the SLPI gene expression in vivo in response to inflammatory stimuli at the site of inflammation...
  64. ncbi request reprint Cloning of 67-kDa laminin receptor cDNA and gene expression in normal and malignant cell lines of the human lung
    K Satoh
    Department of Internal Medicine, Tohoku University, Sendai, Japan
    Cancer Lett 62:199-203. 1992
    ..These differences in the secondary structure of the protein, however, were caused by nucleotide substitutions. It was also demonstrated that the level of 67-kDa-laminin receptor mRNA was higher in SBC3 than in IMR90...
  65. ncbi request reprint Changes of phagocytic capacity in basic fibroblast growth factor-transfected iris pigment epithelial cells in rats
    M Sakuragi
    Department of Ophthalmology, Tohoku University, School of Medicine, Sendai, Miyagi, Japan
    Curr Eye Res 23:185-91. 2001
    ..This increase was inhibited by pretreatment with anti-bFGF antibody to bFGF-IPE. CONCLUSIONS: IPE showed phagocytic capacity, but it reached only 70% of that in RPE. The stable expression of bFGF promoted its function...
  66. doi request reprint Randomized phase II trial of weekly paclitaxel combined with carboplatin versus standard paclitaxel combined with carboplatin for elderly patients with advanced non-small-cell lung cancer
    T Sakakibara
    Department of Respiratory Medicine, Tohoku University Hospital, 1 1 Seiryomachi, Aoba ku, Sendai, Japan
    Ann Oncol 21:795-9. 2010
    ..We conducted a randomized phase II study to compare the efficacy and safety of weekly paclitaxel combined with carboplatin with those of the standard schedule...
  67. ncbi request reprint A new Leu253Arg mutation in the RP2 gene in a Japanese family with X-linked retinitis pigmentosa
    Y Wada
    Department of Ophthalmology, Tohoku University School of Medicine, Sendai, Japan
    Invest Ophthalmol Vis Sci 41:290-3. 2000
    ..To identify the clinical findings in a Japanese family with X-linked retinitis pigmentosa associated with mutation in codon 253 (Leu253Arg) in the RP2 gene...
  68. ncbi request reprint Visual function after removal of subretinal neovascular membranes in patients with age-related macular degeneration
    T Abe
    Department of Ophthalmology, School of Medicine, Sendai, Miyagi, Japan
    Graefes Arch Clin Exp Ophthalmol 239:927-36. 2001
    ....
  69. ncbi request reprint Ophthalmological findings in patients with spinocerebellar ataxia type 1 are not correlated with neurological anticipation
    T Abe
    Department of Ophthalmology, Tohoku University School of Medicine, Miyagi, Japan
    Graefes Arch Clin Exp Ophthalmol 239:722-8. 2001
    ..The purpose of this study was to determine whether the ophthalmological findings are correlated with the neurological disorders, and whether ophthalmological anticipation is present in patients with SCA1...
  70. ncbi request reprint Dedifferentiation of the retinal pigment epithelium compared to the proliferative membranes of proliferative vitreoretinopathy
    T Abe
    Department of Ophthalmology, Tohoku University School of Medicine, Sendai, Miyagi, Japan
    Curr Eye Res 17:1103-9. 1998
    ..To examine the gene expression for melanogenesis of retinal pigment epithelial cells during dedifferentiation and to compare the condition to that of eyes obtaining anatomical success after surgery for proliferative vitreoretinopathy...
  71. ncbi request reprint Autologous iris pigment epithelial cell transplantation in monkey subretinal region
    T Abe
    Department of Ophthalmology, Tohoku University, School of Medicine, Sendai, Japan
    Curr Eye Res 20:268-75. 2000
    ..To establish autologous iris pigment epithelial (IPE) cell transplantation in monkey eyes...
  72. ncbi request reprint Ceramide-induced cell death in cultured rat retinal pigment epithelial cells
    H Tomita
    Department of Ophthalmology, Tohoku University School of Medicine, Sendai, Japan
    Tohoku J Exp Med 190:223-9. 2000
    ..64 microM. Ceramide-induced RPE cell death was inhibited by zVAD-fmk, a CPP32-like protease inhibitor. Our findings indicated that ceramide in RPE cell death functions upstream of CPP32-like proteases...
  73. ncbi request reprint Cytokine gene expression after subretinal transplantation
    T Abe
    Department of Ophthalmology, Tohoku University School of Medicine, Sendai, Japan
    Tohoku J Exp Med 189:179-89. 1999
    ..These cytokines may play an important role for the local reaction after transplantation...
  74. ncbi request reprint Administration of nerve growth factor, brain-derived neurotrophic factor and insulin-like growth factor-II protects phosphate-activated glutaminase in the ischemic and reperfused rat retinas
    H Tomita
    Department of Ophthalmology, Tohoku University School of Medicine, Sendai, Japan
    Tohoku J Exp Med 187:227-36. 1999
    ..BDNF, NGF and IGF-II have marked effect on the protection of PAG activity in the ischemic and reperfused rat retinas, whereas bFGF, which is very effective for the protection of ischemic cell death, shows moderate effect...
  75. ncbi request reprint Correlation of varicella-zoster virus copies and final visual acuities of acute retinal necrosis syndrome
    T Abe
    Department of Ophthalmology, Tohoku University School of Medicine, Miyagi, Japan
    Graefes Arch Clin Exp Ophthalmol 236:747-52. 1998
    ..In spite of aggressive anti-viral therapy, the clinical courses and final visual acuities among these patients have varied. Our purpose was to estimate the amount of virus and compare it to final visual acuity in patients with ARN...
  76. pmc Rat kidney thromboxane receptor: molecular cloning, signal transduction, and intrarenal expression localization
    T Abe
    Second Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan
    J Clin Invest 96:657-64. 1995
    ..The present study will provide important insights into the etiology and pathophysiology of renal diseases with relation to TX metabolism...
  77. ncbi request reprint Two isoforms of the rat kidney EP3 receptor derived by alternative RNA splicing: intrarenal expression co-localization
    K Takeuchi
    Second Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan
    Biochem Biophys Res Commun 199:834-40. 1994
    ..rEP3A and rEP3B receptors are suggested to be derived by alternative RNA splicing, and both receptors are co-localized to distal tubules exerting an effect on water and electrolyte metabolism...
  78. ncbi request reprint Characterization of the efflux transport of 17beta-estradiol-D-17beta-glucuronide from the brain across the blood-brain barrier
    D Sugiyama
    Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan
    J Pharmacol Exp Ther 298:316-22. 2001
    ..Taking the selectivity of these inhibitors into consideration, the maximum contribution made by the Oatp2 and Oat family to the total efflux of E(2)17betaG from the brain appears to be about 40 and 20%, respectively...
  79. pmc Diminution of 37-kDa laminin binding protein expression reduces tumour formation of murine lung cancer cells
    K Satoh
    Department of Respiratory Oncology and Molecular Medicine, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    Br J Cancer 80:1115-22. 1999
    ..These results suggest that the suppressed expression of 37LBP/p40 reduces the capability of lung cancer cell proliferation in vitro and tumour formation in vivo...
  80. ncbi request reprint Molecular cloning and expression of a rat cDNA encoding MDCK-type chloride channel
    T Abe
    Department of Clinical Biology and Hormonal Regulation, Tohoku University School of Medicine, Sendai, Japan
    Biochim Biophys Acta 1173:353-6. 1993
    ..The rat kidney chloride channel, abbreviated RKCL, is not specific to the kidney, but widely expressed in various tissues. It is suggested that RKCL is important for most cells...
  81. ncbi request reprint Purification and characterization of a 39,000-Da serine proteinase from the hemolymph of a solitary ascidian, Halocynthia roretzi
    F Shishikura
    Department of Biology, Nihon University School of Medicine, Tokyo, Japan
    Comp Biochem Physiol B Biochem Mol Biol 118:131-41. 1997
    ..We also demonstrated the clotting enzyme activity of the purified serine proteinase toward bovine fibrinogen and Limulus coagulogen, a fibrinogen-like clottable protein of horseshoe crabs...
  82. ncbi request reprint Structure and regulation of rat long-chain acyl-CoA synthetase
    H Suzuki
    Tohoku University Gene Research Center, Sendai, Japan
    J Biol Chem 265:8681-5. 1990
    ..The level of long-chain acyl-CoA synthetase mRNA is increased 7-8-fold in rat liver by feeding a diet high in carbohydrate or fat, consistent with the physiological significance of the enzyme in fatty acid metabolism...
  83. ncbi request reprint Gene expression related to cholesterol metabolism in mouse brain during development
    S Hanaka
    Department of Pediatrics, Teikyo University School of Medicine, 2 11 1 Kaga, Itabashi ku, 173 8605, Tokyo, Japan
    Brain Dev 22:321-6. 2000
    ....
  84. ncbi request reprint Primary natural killer cell lymphoma of the lacrimal sac
    T Mori
    Department of Medicine, Keio University School of Medicine, Tokyo, Japan
    Ann Hematol 80:607-10. 2001
    ..However, shortly after completion of chemoradiotherapy, the lymphoma relapsed with rapid systemic dissemination. The disease was refractory to chemotherapy, and the patient eventually succumbed due to sepsis...
  85. ncbi request reprint Transduction of thymidine phosphorylase cDNA facilitates efficacy of cytosine deaminase/5-FC gene therapy for malignant brain tumor
    Y Manome
    Department of Microbiology, Jikei University School of Medicine, Tokyo, Japan
    Anticancer Res 21:2265-72. 2001
    ..These results suggest that transduction of thymidine phosphorylase may be a beneficial approach to increasing the efficacy of cd/5-FC suicide gene therapy in certain types of tumor...
  86. ncbi request reprint Isolation and characterization of the human gene homologous to the Drosophila headcase (hdc) gene in chromosome bands 6q23-q24, a region of common deletion in human pancreatic cancer
    N Makino
    Department of Molecular Pathology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    DNA Seq 11:547-53. 2001
    ..6-kb transcript. Seventeen (81%) of 21 pancreatic cancer cell lines and four (80%) of five renal cell carcinoma cell lines showed low level expression, suggesting that the hHDC gene may play an important role in some human cancers...
  87. ncbi request reprint Comparative analysis of host responses related to immunosuppression between measles patients and vaccine recipients with live attenuated measles vaccines
    H Okada
    Department of Viral Diseases and Vaccine Control, National Institute of Infectious Diseases, Musashi-Murayama, Tokyo, Japan
    Arch Virol 146:859-74. 2001
    ....
  88. ncbi request reprint A missense mutation in the Na(+)/glucose cotransporter gene SGLT1 in a patient with congenital glucose-galactose malabsorption: normal trafficking but inactivation of the mutant protein
    M Kasahara
    Laboratory of Biophysics, School of Medicine, Teikyo University, Hachioji, Tokyo, Japan
    Biochim Biophys Acta 1536:141-7. 2001
    ..These results indicate that the patient is a compound heterozygote for this disease, and that the Arg(135)-->Trp mutant of SGLT1 undergoes normal trafficking to the plasma membrane but is non-functional...
  89. ncbi request reprint Novel arbekacin- and amikacin-modifying enzyme of methicillin-resistant Staphylococcus aureus
    S Fujimura
    Department of Respiratory Oncology and Molecular Medicine, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    FEMS Microbiol Lett 190:299-303. 2000
    ..A change in protein conformation could lead to a cleavage and a change of the enzymatic activity. We propose a new aminoglycoside-resistance mediated by AAC(4''') is caused by a mutation-modified AAC(6')-APH(2")...
  90. ncbi request reprint Expression of organic anion transporting polypeptide E (OATP-E) in human placenta
    K Sato
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, 980 8574, Japan
    Placenta 24:144-8. 2003
    ..To examine the expression of multifunctional Na(+)-independent organic anion transporting polypeptide, termed OATP-E, involved in the transport of thyroid hormone in human placenta...
  91. pmc In vitro and in vivo antibacterial activities of CS-834, a novel oral carbapenem
    T Fukuoka
    Biological Research Laboratories, Sankyo Co, Ltd, Tokyo, Japan
    Antimicrob Agents Chemother 41:2652-63. 1997
    ..pneumoniae, E. coli, Citrobacter freundii, and Proteus vulgaris. Among the drugs tested, CS-834 showed the highest efficacy against experimental pneumonia in mice caused by penicillin-resistant S. pneumoniae...
  92. ncbi request reprint The impact of subject/respondent characteristics on a proxy-rated quality of life instrument for the Japanese elderly with dementia
    N Yamamoto-Mitani
    TBI Rehabilitation Research Center, Tokyo, Japan
    Qual Life Res 13:845-55. 2004
    ..Possible reasons for these associations and how to deal with them are discussed. Careful control for those factors is needed when the QLDJ is used in future research...
  93. ncbi request reprint Genetic expression of Menkes disease in cultured astrocytes of the macular mouse
    H Kodama
    Department of Pediatrics, Teikyo University, School of Medicine, Tokyo, Japan
    J Inherit Metab Dis 14:896-901. 1991
    ..These results show that the underlying genetic defect of the macular mouse is expressed in the astrocytes. A similar situation may exist in Menkes disease and cause a failure of copper transport to neurones...
  94. ncbi request reprint Distribution of organic anion-transporting polypeptide 2 (oatp2) and oatp3 in the rat retina
    Aki Ito
    Department of Ophthalmology, Division of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai, 980 8574, Japan
    Invest Ophthalmol Vis Sci 43:858-63. 2002
    ..To examine the expression of multifunctional Na(+)-independent organic anion-transporting polypeptides, termed oatp1, oatp2, and oatp3, involving the transport of thyroid hormone in the rat retina at the protein and mRNA levels...
  95. ncbi request reprint Involvement of multiple transporters in the efflux of 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors across the blood-brain barrier
    Ryota Kikuchi
    Department of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Pharmacol Exp Ther 311:1147-53. 2004
    ..The results of the present study suggest the involvement of multiple transporters, including rOat3 and rOatp2, in the efflux transport of pravastatin and pitavastatin across the BBB, each making a different contribution...
  96. ncbi request reprint Farnesoid X receptor, hepatocyte nuclear factors 1alpha and 3beta are essential for transcriptional activation of the liver-specific organic anion transporter-2 gene
    Hideo Ohtsuka
    Division of Gastroenterological Surgery, Department of Surgery, Tohoku University Graduate School of Medical Science, Sendai 980 8574, Japan
    J Gastroenterol 41:369-77. 2006
    ..In this study, we analyzed the transcriptional regulation of the LST-2 gene in hepatocyte-derived cells and the effect of bile acid...
  97. ncbi request reprint OATP1B1, OATP1B3, and mrp2 are involved in hepatobiliary transport of olmesartan, a novel angiotensin II blocker
    Rie Nakagomi-Hagihara
    Drug Metabolism and Pharmacokinetics Research Laboratories, Sankyo Co, Ltd, 1 2 58 Hiromachi, Tokyo, 140 8710, Japan
    Drug Metab Dispos 34:862-9. 2006
    ..In conclusion, the hepatic uptake and biliary excretion of olmesartan are mediated by transporters in humans. OATP1B1 and OATP1B3 are involved in hepatic uptake, at least in part, and MRP2 plays a dominant role in the biliary excretion...
  98. ncbi request reprint Mesangial proliferative glomerulonephritis with aldosterone-producing adenoma
    Masayuki Tanemoto
    Division of Nephrology, Hypertension and Endocrinology, Department of Medicine, Tohoku University Graduate School of Medicine, 1 1 Seiryo cho, Aoba ku, Sendai, Miyagi 980 8574, Japan
    Clin Exp Nephrol 11:164-7. 2007
    ..A dissociated response of hematuria and proteinuria to antihypertensive treatment indicated that MesPGN was coincidental with APA...
  99. ncbi request reprint Human liver-specific organic anion transporter-2 is a potent prognostic factor for human breast carcinoma
    Mitsuhisa Muto
    Division of Gastroenterological Surgery, Tohoku University Graduate School of Medicine, Sendai 2980 8574, Japan
    Cancer Sci 98:1570-6. 2007
    ..The results of our present study demonstrate that LST-2 immunoreactivity is a potent prognostic factor in human breast cancer...
  100. ncbi request reprint Brain-to-blood elimination of 24S-hydroxycholesterol from rat brain is mediated by organic anion transporting polypeptide 2 (oatp2) at the blood-brain barrier
    Sumio Ohtsuki
    Department of Molecular Biopharmacy and Genetics, Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba, Aramaki, Aoba ku, Sendai, Japan
    J Neurochem 103:1430-8. 2007
    ..These results are the first direct demonstration that 24S-OH-chol undergoes elimination from the brain to blood across the BBB via a carrier-mediated process, which involves oatp2 expressed at the BBB in rats...
  101. ncbi request reprint Rapid screening of antineoplastic candidates for the human organic anion transporter OATP1B3 substrates using fluorescent probes
    Hiroaki Yamaguchi
    Department of Pharmaceutical Sciences, Tohoku University Hospital, Division of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan
    Cancer Lett 260:163-9. 2008
    ..In conclusion, our results demonstrate that the screening system established in this study is a useful method for the rapid extraction of candidate therapeutic agents from the large numbers of compounds...