Kazutoshi Shibuya

Summary

Affiliation: Toho University
Country: Japan

Publications

  1. ncbi Diagnosis of systemic toxoplasmosis with HIV infection using DNA extracted from paraffin-embedded tissue for polymerase chain reaction: a case report
    Yoichiro Okubo
    Department of Surgical Pathology, Toho University School of Medicine, 6 11 1 Omori Nishi, Ota ku, Tokyo, 143 8541, Japan
    J Med Case Reports 4:265. 2010
  2. ncbi Histopathology of cryptococcosis and other fungal infections in patients with acquired immunodeficiency syndrome
    K Shibuya
    Department of Pathology, Toho University Ohashi Hospital, Tokyo, Japan
    Int J Infect Dis 5:78-85. 2001
  3. ncbi Granuloma and cryptococcosis
    Kazutoshi Shibuya
    Department of Pathology, Omori Hospital, Toho University School of Medicine, 6 11 1 Omori Nishi, Ota ku, Tokyo, 143 8541, Japan
    J Infect Chemother 11:115-22. 2005
  4. ncbi Pathophysiology of pulmonary aspergillosis
    Kazutoshi Shibuya
    Department of Pathology, Omori Hospital, Toho University School of Medicine, 6 11 1 Omori Nishi, Ota ku, 143 8541, Tokyo, Japan
    J Infect Chemother 10:138-45. 2004
  5. ncbi Allergic fungal sinusitis caused by Bipolaris spicifera and Schizophyllum commune
    Katsuji Taguchi
    Department of Pathology, Toho University Ohashi Medical Center, Tokyo, Japan
    Med Mycol 45:559-64. 2007
  6. ncbi Deep-seated mycosis as a complication in bone marrow transplantation patients
    M Wakayama
    Department of Pathology, Ohashi Hospital, Toho University School of Medicine, Tokyo, Japan
    Mycoses 45:146-51. 2002
  7. ncbi Literature survey on epidemiology and pathology of gangliocytic paraganglioma
    Yoichiro Okubo
    Department of Surgical Pathology, Toho University School of Medicine, 6 11 1 Omori Nishi, Ota ku, Tokyo, 143 8541, Japan
    BMC Cancer 11:187. 2011
  8. ncbi Pulmonary tumor thrombotic microangiopathy induced by gastric carcinoma: morphometric and immunohistochemical analysis of six autopsy cases
    Yoichiro Okubo
    Department of Surgical Pathology, Toho University School of Medicine, 6 11 1, Omori Nishi, Ota ku, Tokyo, 143 8541, Japan
    Diagn Pathol 6:27. 2011
  9. ncbi [Pathophysiology of invasive fungal infection in diabetic patients]
    Yoichiro Okubo
    Department of Surgical Pathology, Toho University School of Medicine
    Nihon Rinsho 66:2327-33. 2008
  10. ncbi Trends in the prevalence of invasive fungal infections from an analysis of annual records of autopsy cases of Toho University
    Kayoko Shimodaira
    Department of Surgical Pathology, Toho University School of Medicine, Tokyo, Japan
    Mycoses 55:435-43. 2012

Collaborators

Detail Information

Publications46

  1. ncbi Diagnosis of systemic toxoplasmosis with HIV infection using DNA extracted from paraffin-embedded tissue for polymerase chain reaction: a case report
    Yoichiro Okubo
    Department of Surgical Pathology, Toho University School of Medicine, 6 11 1 Omori Nishi, Ota ku, Tokyo, 143 8541, Japan
    J Med Case Reports 4:265. 2010
    ..However, toxoplasmic meningitis in a patient with HIV infection is extremely rare and purulent or tuberculous meningitis should be considered initially as a disease for differential diagnosis in Japan...
  2. ncbi Histopathology of cryptococcosis and other fungal infections in patients with acquired immunodeficiency syndrome
    K Shibuya
    Department of Pathology, Toho University Ohashi Hospital, Tokyo, Japan
    Int J Infect Dis 5:78-85. 2001
    ..To gain insight into the histopathologic characteristics of fungal infection in acquired immunodeficiency syndrome (AIDS)...
  3. ncbi Granuloma and cryptococcosis
    Kazutoshi Shibuya
    Department of Pathology, Omori Hospital, Toho University School of Medicine, 6 11 1 Omori Nishi, Ota ku, Tokyo, 143 8541, Japan
    J Infect Chemother 11:115-22. 2005
    ....
  4. ncbi Pathophysiology of pulmonary aspergillosis
    Kazutoshi Shibuya
    Department of Pathology, Omori Hospital, Toho University School of Medicine, 6 11 1 Omori Nishi, Ota ku, 143 8541, Tokyo, Japan
    J Infect Chemother 10:138-45. 2004
    ..This is also confirmed by the reports emphasizing the importance of CT scans to identify hallmark clinical signs and symptoms of the disease...
  5. ncbi Allergic fungal sinusitis caused by Bipolaris spicifera and Schizophyllum commune
    Katsuji Taguchi
    Department of Pathology, Toho University Ohashi Medical Center, Tokyo, Japan
    Med Mycol 45:559-64. 2007
    ..It is very important in the diagnosis of AFS to demonstrate the presence of fungal elements in the allergic mucin. Squash cytology of the paranasal sinus contents was especially useful for proving the presence of fungi...
  6. ncbi Deep-seated mycosis as a complication in bone marrow transplantation patients
    M Wakayama
    Department of Pathology, Ohashi Hospital, Toho University School of Medicine, Tokyo, Japan
    Mycoses 45:146-51. 2002
    ....
  7. ncbi Literature survey on epidemiology and pathology of gangliocytic paraganglioma
    Yoichiro Okubo
    Department of Surgical Pathology, Toho University School of Medicine, 6 11 1 Omori Nishi, Ota ku, Tokyo, 143 8541, Japan
    BMC Cancer 11:187. 2011
    ..We therefore aimed to investigate the details of this disease by carefully analyzing and extracting common features of the disease as presented in selected publications...
  8. ncbi Pulmonary tumor thrombotic microangiopathy induced by gastric carcinoma: morphometric and immunohistochemical analysis of six autopsy cases
    Yoichiro Okubo
    Department of Surgical Pathology, Toho University School of Medicine, 6 11 1, Omori Nishi, Ota ku, Tokyo, 143 8541, Japan
    Diagn Pathol 6:27. 2011
    ..However, the pathogenesis and pathophysiology of this debilitating condition still remains obscure and no effective management was recommended. The present study aims to elucidate the pathophysiology of PTTM...
  9. ncbi [Pathophysiology of invasive fungal infection in diabetic patients]
    Yoichiro Okubo
    Department of Surgical Pathology, Toho University School of Medicine
    Nihon Rinsho 66:2327-33. 2008
    ..We wish to draw that pathophysiological explanation still remains obscuring of relationship between diabetes and invasive fungal infection...
  10. ncbi Trends in the prevalence of invasive fungal infections from an analysis of annual records of autopsy cases of Toho University
    Kayoko Shimodaira
    Department of Surgical Pathology, Toho University School of Medicine, Tokyo, Japan
    Mycoses 55:435-43. 2012
    ..IFIs were also detected in an immunocompromised state caused not only by primary disease but also by treatment with anti-tumour drugs and corticosteroids...
  11. ncbi Recovery of lung perfusion after sleeve resection for tuberculous bronchial stenosis
    Shoji Takahashi
    Department of Chest Surgery, Pulmonary Medicine and Surgical Pathology, Toho University Omori Medical Center, Tokyo, Japan
    Ann Thorac Surg 93:2041-3. 2012
    ..Symptoms abated and perfusion recovered to a large extent 2 months later. She became pregnant and delivered successfully 12 months postoperatively...
  12. ncbi Identification of Fusarium species in formalin-fixed and paraffin-embedded sections by in situ hybridization using peptide nucleic acid probes
    Minoru Shinozaki
    Department of Surgical Pathology, Toho University School of Medicine, 6 11 1 Omori Nishi, Ota ku, Tokyo 143 8541, Japan
    J Clin Microbiol 49:808-13. 2011
    ..In conclusion, it was confirmed that ISH with PNA probes is accurate and is a valuable tool for identifying Fusarium spp. among organisms that have identical morphological features in formalin-fixed and paraffin-embedded sections...
  13. ncbi Usefulness of fluoro-2-deoxyglucose positron emission tomography for investigating unexplained rising carcinoembryonic antigen levels that occur during the postoperative surveillance of lung cancer patients
    Kazutoshi Isobe
    Department of Respiratory Medicine, Toho University Omori Medical Center, 6 11 1 Omori Nishi, Ota ku, Tokyo 143 8541, Japan
    Int J Clin Oncol 14:497-501. 2009
    ..In this study, we evaluated the selected use of FDG-PET for lung cancer patients with re-elevated levels of serum carcinoembryonic antigen (CEA) after curative surgery...
  14. ncbi Development and evaluation of nucleic acid-based techniques for an auxiliary diagnosis of invasive fungal infections in formalin-fixed and paraffin-embedded (FFPE) tissues
    Minoru Shinozaki
    Department of Surgical Pathology, Toho University School of Medicine, Tokyo, Japan
    Med Mycol J 53:241-5. 2012
    ....
  15. ncbi Development of a peptide nucleic acid probe to Trichosporon species and identification of trichosporonosis by use of in situ hybridization in formalin-fixed and paraffin-embedded (FFPE) sections
    Minoru Shinozaki
    Department of Surgical Pathology, Toho University School of Medicine, Tokyo, Japan
    J Clin Microbiol 51:295-8. 2013
    ..Results confirmed the usefulness of ISH with our PNA probe in identifying Trichosporon species from Candida albicans...
  16. ncbi Pathological response and prognosis of stage III non-small cell lung cancer patients treated with induction chemoradiation
    Kazutoshi Isobe
    Department of Respiratory Medicine, Toho University Omori Medical Center, 6 11 1 Omori Nishi, Ota ku, Tokyo, Japan
    Asia Pac J Clin Oncol 8:260-6. 2012
    ..The aim of this study was to clarify the relationship between pathological effects and the prognosis of patients with stage III non-small cell lung cancer (NSCLC) treated with induction chemoradiation...
  17. ncbi Clinical significance of circulating tumor cells and free DNA in non-small cell lung cancer
    Kazutoshi Isobe
    Department of Respiratory Medicine, Toho University Omori Medical Center, 6 11 1 Omori Nishi, Ota ku, Tokyo 143 8541, Japan
    Anticancer Res 32:3339-44. 2012
    ....
  18. ncbi Pulmonary hamartoma diagnosed by convex probe endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA)
    Yoshinobu Hata
    Department of Chest Surgery, Toho University Medical Center Omori Hospital, Tokyo, Japan
    Intern Med 49:1171-3. 2010
    ..CP-EBUS images are easier to interpret than other methods for monitoring respiratory dynamics. We conclude that CP-EBUS is a useful addition to techniques both for non-invasive imaging as well as guiding pathological examination...
  19. ncbi [Deep-seated mycosis in patients with solid-organ transplantation--a study of autopsied cases in the United States]
    M Wakayama
    Department of Pathology, Ohashi Hospital, Toho University School of Medicine
    Kansenshogaku Zasshi 74:378-86. 2000
    ..The above suggests that from this standpoint, improvement of prophylactic and therapeutic technique against aspergillosis is the greatest problem in deep-seated mycosis in SOT patients...
  20. ncbi Applied gene histopathology: identification of Fusarium species in FFPE tissue sections by in situ hybridization
    Yoichiro Okubo
    Department of Surgical Pathology, Toho University School of Medicine, Ota ku, Tokyo, Japan
    Methods Mol Biol 968:141-7. 2013
    ..from other molds. In this chapter, we present our in situ hybridization (ISH) technique as a valuable tool to identify Fusarium spp. and emphasize the usefulness of the technique...
  21. ncbi Literature survey on epidemiology and pathology of cardiac fibroma
    Suguru Torimitsu
    Department of Surgical Pathology, Toho University School of Medicine, 6 11 1 Omori Nishi, Ota ku, Tokyo 143 8541, Japan
    Eur J Med Res 17:5. 2012
    ..Unfortunately, only a few studies have reported the epidemiology, embryology, and histopathology of the tumor, and the factors predicting poorer outcome are still obscured...
  22. ncbi A case of concomitant occurrence of struma ovarii and malignant transformation of cystic teratoma
    Norihiko Saito
    Second Department of Neurosurgery, Toho University School of Medicine, and Mita Hospital, Tokyo, Japan
    Int J Surg Pathol 15:318-20. 2007
    ..As for the identification of the origin of adenocarcinomas arising from mature ovarian cystic teratomas, more cases need to be identified and investigated...
  23. ncbi Cellular kinetics and K-ras codon 12 mutations according to histomorphometric type of colorectal polyps with epithelial serrated proliferation
    Shigeharu Hamatani
    Department of Pathology, Ohmori Hospital, Toho University School of Medicine, 6 11 1 Ohmori nishi, Ohta ku, Tokyo 143 8541, Japan
    Oncol Rep 14:121-7. 2005
    ..Preliminary evidence indicates some relation between K-ras mutations and structural atypia associated with lateral branching of the crypts...
  24. ncbi Histopathology of deep-seated fungal infections and detailed examination of granulomatous response against cryptococci in patients with acquired immunodeficiency syndrome
    Kazutoshi Shibuya
    Department of Pathology, Omori Hospital, Toho University School of Medicine, Tokyo, Japan
    Nippon Ishinkin Gakkai Zasshi 43:143-51. 2002
    ..The third pattern demonstrated in the patient treated with HAART was characterized by the presence of CD4+ cells, greater response of histiocytes and multinucleated giant cell formation, and lack of massive capillary involvement...
  25. ncbi Application of in situ hybridization to tissue sections for identification of molds causing invasive fungal infection
    Minoru Shinozaki
    Department of Surgical Pathology, Toho University School of Medicine, 6 11 1 Omori Nishi, Ota ku, Tokyo, Japan
    Nihon Ishinkin Gakkai Zasshi 50:75-83. 2009
    ..We wish to emphasize that ISH can be a valuable tool to identify medically important molds in formalin-fixed and paraffin-embedded tissue sections or cytological preparations...
  26. ncbi Histopathological features of murine systemic vasculitis caused by Candida albicans extract--an animal model of Kawasaki disease
    K Takahashi
    Department of Pathology, Ohashi Hospital, Toho University School of Medicine, 2 17 6, Ohashi, Meguro, Tokyo, 153 8515, Japan
    Inflamm Res 53:72-7. 2004
    ..We examined the histopathological features of systemic vasculitis caused in mice by injection of a Candida albicans ( C. albicans) extract and investigated the principal genetic roles in the development of vasculitis...
  27. ncbi A half-century of autopsy results--incidence of pediatric vasculitis syndromes, especially Kawasaki disease
    Kei Takahashi
    Department of Pathology, Toho University Ohashi Medical Center, Tokyo 153 8515, Japan
    Circ J 76:964-70. 2012
    ....
  28. ncbi Leiomyosarcoma with partial rhabdomyoblastic differentiation: first case report of primary cardiac origin
    Yoichiro Okubo
    Department of Surgical Pathology, Toho University School of Medicine, 6 11 1 Omori Nishi, Ota ku, Tokyo 143 8541, Japan
    BMC Cancer 11:76. 2011
    ..Previous studies of leiomyosarcoma with rhabdomyoblastic differentiation have conducted to those arisen from another site, and they indicated a poorer prognosis of this tumor...
  29. ncbi Pathophysiological study of chronic necrotizing pulmonary aspergillosis
    Keishi Sugino
    Department of Respiratory Medicine, Toho University Omori Medical Center, Tokyo, Japan
    Jpn J Infect Dis 61:450-3. 2008
    ..Surgical intervention should be considered as a prior procedure for CNPA patients, because vessels at the cavity wall, whether occluded completely or incompletely, are usually necrotic and/or show local invasion of Aspergilli...
  30. ncbi Pathological study of postcoronary arteritis in adolescents and young adults: with reference to the relationship between sequelae of Kawasaki disease and atherosclerosis
    K Takahashi
    Department of Pathology, Ohashi Hospital, Toho University School of Medicine, Meguro, Tokyo, Japan
    Pediatr Cardiol 22:138-42. 2001
    ..The findings in this study suggest that aneurysms present in coronary arteries in individuals with a history of KD constitute a risk factor for atherosclerosis later in life...
  31. ncbi Duodenal gangliocytic paraganglioma showing lymph node metastasis: a rare case report
    Yoichiro Okubo
    Department of Surgical Pathology, Toho University School of Medicine, 6 11 1 Omori Nishi, Ota ku, Tokyo, 143 8541, Japan
    Diagn Pathol 5:27. 2010
    ..In addition to the rarity of the tumor, we are describing here the present case suggests the malignant potency of the tumor despite lack of acceptable prognostic indicators for neuroendocrine tumor...
  32. ncbi Dynamics of global gene expression changes during brain metastasis formation
    Norihiko Saito
    Second Department of Neurosurgery, Toho University School of Medicine, Meguro ku, Tokyo, Japan
    Neuropathology 29:389-97. 2009
    ..The microarray results reported here strongly suggest that a large number of genes exhibit a spike pattern, which is tantamount to phase-specific expression...
  33. ncbi Histopathological study on experimental endophthalmitis induced by bloodstream infection with Candida albicans
    Junko Omuta
    First Department of Ophthalmology, Toho University School of Medicine, Tokyo 143 8541, Japan
    Jpn J Infect Dis 60:33-9. 2007
    ..Our results indicate that ophthalmic examination is useful to monitor the development and systemic involvement of endophthalmitis in patients with candidemia...
  34. ncbi A case of juvenile acromegaly that was initially diagnosed as severe congestive heart failure from acromegaly-induced dilated cardiomyopathy
    Mariko Sue
    Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine Omori, Toho University School of Medicine, Tokyo
    Intern Med 49:2117-21. 2010
    ..Immediate diagnosis and treatment are required for better control of acromegalic cardiomyopathy...
  35. ncbi Catalases of Aspergillus fumigatus and inflammation in aspergillosis
    Kazutoshi Shibuya
    Department of Surgical Pathology, Toho University School of Medicine, Tokyo, Japan
    Nippon Ishinkin Gakkai Zasshi 47:249-55. 2006
    ..Consequently, it should be emphasized that conidial catalase is not a virulence factor but that mycelial catalases transiently protect the fungus from the host defence reactions...
  36. ncbi Pathogenesis of Kawasaki disease
    K Takahashi
    Department of Pathology, Toho University Ohashi Medical Center, Tokyo, Japan
    Clin Exp Immunol 164:20-2. 2011
    ..There is no fibrinoid necrosis nor any mixture of acute inflammatory lesions and scarring lesions, which are characteristics in polyarteritis nodosa in KD...
  37. ncbi Compensatory response of IL-1 gene knockout mice after pulmonary infection with Klebsiella pneumoniae
    Masaaki Tanabe
    Department of Microbiology, Omori Hospital, Toho University School of Medicine, 5 21 16 Omori nishi, Ota ku Tokyo, Japan
    J Med Microbiol 54:7-13. 2005
    ..The data suggest that compensatory production of TNF-alpha in IL-1 KO mice contributes to the host defence against K. pneumoniae infection...
  38. ncbi Identification of the putative protein phosphatase gene PTC1 as a virulence-related gene using a silkworm model of Candida albicans infection
    Nozomu Hanaoka
    Department of Bioactive Molecules, National Institute of Infectious Diseases, Toyama, Tokyo, Japan
    Eukaryot Cell 7:1640-8. 2008
    ..Characterization of ptc1Delta revealed other phenotypic traits, including reduced hyphal growth in vitro and in vivo, and reduced extracellular proteolytic activity. We conclude that PTC1 may contribute to pathogenicity in C. albicans...
  39. ncbi Establishment and characterization of a novel cell line derived from a human small cell lung carcinoma that secretes parathyroid hormone, parathyroid hormone-related protein, and pro-opiomelanocortin
    Mayumi Ishikawa
    Division of Diabetes, Metabolism and Endocrinology, Toho University School of Medicine, 6 11 1, Omori Nishi, Ota ku, Tokyo 143 8541, Japan
    Hum Cell 23:58-64. 2010
    ..In summary, we established a novel cell line, SS-1 from SCLC, which produced PTHrP, PTH and N terminal POMC...
  40. ncbi Late onset postoperative pulmonary fistula following a pulmonary segmentectomy using electrocautery or a harmonic scalpel
    Keigo Takagi
    Department of Chest Surgery, Toho University Medical Center Omori Hospital, 6 11 1 Omori Nishi, Ota ku, Tokyo, Japan
    Ann Thorac Cardiovasc Surg 16:21-5. 2010
    ..The purpose of this study is to retrospectively examine the postoperative pulmonary fistula as a complication after the use of either electrocautery or a harmonic scalpel without stapling devices...
  41. ncbi Current status of diagnosis and treatment of invasive fungal infections in Japan: the influence of the new Japanese guidelines
    Naoki Aikawa
    Keio University Hospital, 35 Shinanomachi, Shinjuku ku, Tokyo, 160 8582, Japan
    J Infect Chemother 11:278-87. 2005
    ..Definitive diagnoses of invasive fungal infection are too scarce at the national level. The cooperation of clinicians for organizing more definitive diagnoses would be appreciated when the guidelines are revised...
  42. ncbi Contribution of myeloperoxidase to coronary artery vasculitis associated with MPO-ANCA production
    A Ishida-Okawara
    Department of Bioactive Molecules, National Institute of Infectious Diseases, Tokyo, Japan
    Inflammation 25:381-7. 2001
    ..Vasculitis did develop in a few MPO-deficient mice, though the incidence of vasculitis was much lower in MPO-deficient mice than in C57BL/6 mice...
  43. ncbi Thyroid papillary carcinoma recurring as squamous cell carcinoma: report of a case
    Shinzo Kitahara
    Department of General and Digestive Surgery, Toho University, 6-11-1 Omori Nishi, Otaku, Tokyo, 143-8541, Japan
    Surg Today 36:171-4. 2006
    ..We report this case as an example of how squamous cell carcinoma of the thyroid can develop...
  44. ncbi Lack of human herpesvirus 8 infection in lungs of Japanese patients with primary pulmonary hypertension
    Harutaka Katano
    Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan
    J Infect Dis 191:743-5. 2005
    ..HHV-8 DNA could not be amplified by polymerase chain reaction for the HHV-8-encoded K1 and KS330(233) genes in any sample. These data suggest that HHV-8 infection is not associated with PPH in Japanese patients...
  45. ncbi [A case of allergic fungal sinusitis caused by Bipolaris spicifera]
    Katsuji Taguchi
    Department of Pathology, Ohashi Hospital, Toho University School of Medicine, 2-17-6 Ohashi, Meguro-ku, Tokyo 153-8515, Japan
    Nippon Ishinkin Gakkai Zasshi 45:239-45. 2004
    ....
  46. ncbi Clinical characteristics of acute respiratory deterioration in pulmonary fibrosis associated with lung cancer following anti-cancer therapy
    Kazutoshi Isobe
    Departments of Respiratory Medicine, oho University Omori Medical Center, 6 11 1 Omori Nishi, Ota ku, Tokyo 143 8541, Japan
    Respirology 15:88-92. 2010
    ..To clarify the clinical characteristics and risk factors for acute respiratory deterioration following anti-cancer therapy in patients with pulmonary fibrosis (PF) and lung cancer...