Yasuo Iwasaki

Summary

Affiliation: Toho University
Country: Japan

Publications

  1. ncbi request reprint Vasoactive intestinal peptide influences neurite outgrowth in cultured rat spinal cord neurons
    Y Iwasaki
    The Fourth Department of Internal Medicine, Toho University Ohashi Hospital, Tokyo, Japan
    Neurol Res 23:851-4. 2001
  2. ncbi request reprint T-588 protects motor neuron death following axotomy
    Yasuo Iwasaki
    Department of Neurology, Toho University Omori Hospital, Omori Ota ku, Tokyo, Japan
    Neurochem Res 29:403-6. 2004
  3. ncbi request reprint T-588 protects motor neuron death against glutamate-induced neurotoxicity
    Yasuo Iwasaki
    Department of Neurology, Toho University Omori Hospital, Tokyo, Japan
    Neurochem Res 28:1829-32. 2003
  4. ncbi request reprint Molecular and cellular mechanism of glutamate receptors in relation to amyotrophic lateral sclerosis
    Yasuo Iwasaki
    Fourth Department of Internal Medicine, Toho University Ohashi Hospital, 2 17 6, Ohashi, Meguro ku, Tokyo 153 8515, Japan
    Curr Drug Targets CNS Neurol Disord 1:511-8. 2002
  5. ncbi request reprint Temocapril prevents motor neuron damage and upregulation of cyclooxygenase-II in glutamate-induced neurotoxicity
    Yasuo Iwasaki
    Fourth Department of Internal Medicine, Toho University Ohashi Hospital, 2 17 6 Ohashi Meguro ku, Tokyo 153 8515, Japan
    Neurol Res 25:301-4. 2003
  6. ncbi request reprint Influence of temocapril on cultured ventral spinal cord neurons
    Yasuo Iwasaki
    Fourth Department of Internal Medicine, Toho University Ohashi Hospital, 2 17 6 Ohashi Meguro ku, Tokyo 153 8515, Japan
    Neurochem Res 28:711-4. 2003
  7. ncbi request reprint Protective effect of interleukin-3 and erythropoietin on motor neuron death after neonatal axotomy
    Yasuo Iwasaki
    The Fourth Department of Internal Medicine, Toho University Ohashi Hospital, Tokyo, Japan
    Neurol Res 24:643-6. 2002
  8. ncbi request reprint Neuroprotective actions of FK506 and cyclosporin A on motor neuron survival following neonatal axotomy
    Yasuo Iwasaki
    The Fourth Department of Internal Medicine, Toho University Ohashi Hospital, Tokyo, Japan
    Neurol Res 24:573-6. 2002
  9. ncbi request reprint Trophic effect of olmesartan, a novel AT1R antagonist, on spinal motor neurons in vitro and in vivo
    Yasuo Iwasaki
    Fourth Department of Internal Medicine, Toho University Ohashi Hospital, Tokyo, Japan
    Neurol Res 24:468-72. 2002
  10. ncbi request reprint T-588 enhances neurite outgrowth and choline acetyltransferase in cultured rat spinal ventral horn neurons
    Yasuo Iwasaki
    Fourth Department of Internal Medicine, Toho University Ohashi Hospital, Tokyo, Japan
    Neurochem Res 27:225-8. 2002

Collaborators

Detail Information

Publications58

  1. ncbi request reprint Vasoactive intestinal peptide influences neurite outgrowth in cultured rat spinal cord neurons
    Y Iwasaki
    The Fourth Department of Internal Medicine, Toho University Ohashi Hospital, Tokyo, Japan
    Neurol Res 23:851-4. 2001
    ....
  2. ncbi request reprint T-588 protects motor neuron death following axotomy
    Yasuo Iwasaki
    Department of Neurology, Toho University Omori Hospital, Omori Ota ku, Tokyo, Japan
    Neurochem Res 29:403-6. 2004
    ..Our results showing in vivo neurotrophic activity of T-588 for motor neurons support the applicability of T-588 for the treatment of motor neuron diseases, such as amyotrophic lateral sclerosis and motor neuropathies...
  3. ncbi request reprint T-588 protects motor neuron death against glutamate-induced neurotoxicity
    Yasuo Iwasaki
    Department of Neurology, Toho University Omori Hospital, Tokyo, Japan
    Neurochem Res 28:1829-32. 2003
    ..Our data may provide a rationale for designing a therapeutic strategy for protection against pathologically induced motor neuron damage or cell death such as amyotrophic lateral sclerosis and motor neuropathy...
  4. ncbi request reprint Molecular and cellular mechanism of glutamate receptors in relation to amyotrophic lateral sclerosis
    Yasuo Iwasaki
    Fourth Department of Internal Medicine, Toho University Ohashi Hospital, 2 17 6, Ohashi, Meguro ku, Tokyo 153 8515, Japan
    Curr Drug Targets CNS Neurol Disord 1:511-8. 2002
    ..This review will focus on the current understanding of the molecular and cellular mechanisms of glutamate receptors in relation to ALS...
  5. ncbi request reprint Temocapril prevents motor neuron damage and upregulation of cyclooxygenase-II in glutamate-induced neurotoxicity
    Yasuo Iwasaki
    Fourth Department of Internal Medicine, Toho University Ohashi Hospital, 2 17 6 Ohashi Meguro ku, Tokyo 153 8515, Japan
    Neurol Res 25:301-4. 2003
    ..Taken together, temocapril may have therapeutic potential for diseases which associate with upregulation of COX-II, in addition to its role in glutamate excitotoxicity...
  6. ncbi request reprint Influence of temocapril on cultured ventral spinal cord neurons
    Yasuo Iwasaki
    Fourth Department of Internal Medicine, Toho University Ohashi Hospital, 2 17 6 Ohashi Meguro ku, Tokyo 153 8515, Japan
    Neurochem Res 28:711-4. 2003
    ..A possible therapeutic role for temocapril in damaged motor neurons, such as in motor neuropathy and amyotrophic lateral sclerosis, remains to be defined...
  7. ncbi request reprint Protective effect of interleukin-3 and erythropoietin on motor neuron death after neonatal axotomy
    Yasuo Iwasaki
    The Fourth Department of Internal Medicine, Toho University Ohashi Hospital, Tokyo, Japan
    Neurol Res 24:643-6. 2002
    ....
  8. ncbi request reprint Neuroprotective actions of FK506 and cyclosporin A on motor neuron survival following neonatal axotomy
    Yasuo Iwasaki
    The Fourth Department of Internal Medicine, Toho University Ohashi Hospital, Tokyo, Japan
    Neurol Res 24:573-6. 2002
    ..0 mg kg(-1)) and CsA (10.0 mg kg(-1)) rescued motor neuron death in a similar way. These results indicate therapeutic relevance in the treatment of damaged motor neuron disorders, such as motor neuropathy or amyotrophic lateral sclerosis...
  9. ncbi request reprint Trophic effect of olmesartan, a novel AT1R antagonist, on spinal motor neurons in vitro and in vivo
    Yasuo Iwasaki
    Fourth Department of Internal Medicine, Toho University Ohashi Hospital, Tokyo, Japan
    Neurol Res 24:468-72. 2002
    ..Our data suggest a potential therapeutic use of Olmesartan in treating diseases that involve degeneration and death of motor neurons, such as motor neuropathy and amyotrophic lateral sclerosis...
  10. ncbi request reprint T-588 enhances neurite outgrowth and choline acetyltransferase in cultured rat spinal ventral horn neurons
    Yasuo Iwasaki
    Fourth Department of Internal Medicine, Toho University Ohashi Hospital, Tokyo, Japan
    Neurochem Res 27:225-8. 2002
    ..Our data showing T-588 has neurotrophic action on VSCC and suggests a potential use of T-588 in treating diseases that involve degeneration and death of spinal motor neurons, such as motor neuropathy and motor neuron disease...
  11. doi request reprint Relationship between cervical cord 1H-magnetic resonance spectroscopy and clinoco-electromyographic profile in amyotrophic lateral sclerosis
    Ken Ikeda
    Department of Neurology, Toho University Omori Medical Center, 6 11 1, Omorinishi, Otaku, Tokyo, 143 8541, Japan
    Muscle Nerve 47:61-7. 2013
    ..Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the loss of motor neurons, leading to limb paralysis and respiratory failure...
  12. ncbi request reprint Cardiovascular risk and neuroradiological profiles in asymptomatic vertebrobasilar dolichoectasia
    Ken Ikeda
    Department of Neurology, Toho University Omori Medical Center, Tokyo, Japan
    Cerebrovasc Dis 30:23-8. 2010
    ..Clinicoradiological variability of vertebrobasilar dolichoectasia (VBD) is known. Little is known about cardiovascular disease (CVD) risk and neuroradiological profiles of asymptomatic VBD...
  13. doi request reprint Correlation between depressive symptoms and nocturnal disturbances in Japanese patients with Parkinson's disease
    Keisuke Suzuki
    Department of Neurology, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Tochigi 321 0293, Japan
    Parkinsonism Relat Disord 15:15-9. 2009
    ....
  14. doi request reprint Cheiro-oral syndrome associated with lateral medullary infarction
    Tokinori Sekine
    Department of Neurology, Toho University Omori Medical Centre, 6 11 1, Omori Nishi, Ota ku, Tokyo, 143 8541, Japan
    Neurol Sci 32:321-2. 2011
    ..This is the first reported case of a medullary lesion causing cheiro-oral syndrome...
  15. doi request reprint Excessive daytime sleepiness and sleep episodes in Japanese patients with Parkinson's disease
    Keisuke Suzuki
    Department of Neurology, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Tochigi 321 0293, Japan
    J Neurol Sci 271:47-52. 2008
    ..ESS score of >or=10 had 75% sensitivity and 82.4% specificity for sleep episodes. These results suggest that sleepiness in PD is dependent on disease itself and dopaminergic treatment rather than nocturnal disturbances...
  16. doi request reprint Pulse wave velocity study in middle-aged migraineurs at low cardiovascular disease risk
    Ken Ikeda
    Department of Neurology, Toho University Omori Medical Center, Tokyo, Japan
    Headache 51:1239-44. 2011
    ..Little is known about such arterial changes in Japanese midlife migraineurs. We aimed to evaluate arterial pulse wave velocity (PWV) and ankle-brachial index (ABI) in middle-aged migraineurs at low CVD risk...
  17. doi request reprint Serological profiles of urate, paraoxonase-1, ferritin and lipid in Parkinson's disease: changes linked to disease progression
    Ken Ikeda
    Department of Neurology, Toho University Omori Medical Center, Tokyo, Japan
    Neurodegener Dis 8:252-8. 2011
    ..Oxidative stress plays a role in the pathogenesis of neuronal death. Serum levels of urate or lipid were associated with the incidence of Parkinson's disease (PD)...
  18. ncbi request reprint Oral administration of a neuroprotective compound T-588 prevents motoneuron degeneration after facial nerve avulsion in adult rats
    Ken Ikeda
    Department of Molecular Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Tokyo, Japan
    Amyotroph Lateral Scler Other Motor Neuron Disord 4:74-80. 2003
    ..We investigated whether orally administered T-588 can rescue injured motoneurons after facial nerve avulsion in adult rats...
  19. ncbi request reprint Influenza-associated monophasic neuromyelitis optica
    Yoshikazu Nakamura
    Department of Neurology, Toho University Omori Medical Centre, Japan
    Intern Med 50:1605-9. 2011
    ..This is the first case report of influenza A-associated NMO with such features of postinfectious NMO as a pediatric onset, monophasic course and anti-AQP4 antibody-seronegative status...
  20. ncbi request reprint Cheiro-oral-pedal syndrome due to brainstem hemorrhage
    Osamu Igarashi
    Department of Neurology, Toho University Omori Hospital, 6 11 1 Omorinishi Ota ku, Tokyo 143 8541, Japan
    Clin Neurol Neurosurg 108:507-10. 2006
    ..Cheiro-oral-pedal syndrome is caused by lacunar infarction in majority of the cases. However, it should be kept in mind that hematomas can cause cheiro-oral-pedal syndrome...
  21. ncbi request reprint A case of gliomatosis cerebri mimicking limbic encephalitis: malignant transformation to glioblastoma
    Riya Nagata
    Department of Neurology, Toho University Omori Medical Center, Tokyo
    Intern Med 49:1307-10. 2010
    ..Thus, it is important to pay more attention to the differential diagnoses of GC and LE in patients who have memory deficits and widespread MRI lesions...
  22. pmc Clinically meaningful treatment responses after switching to galantamine and with addition of memantine in patients with Alzheimer's disease receiving donepezil
    Osamu Kano
    Department of Neurology, Toho University Omori Medical Center, Tokyo, Japan
    Neuropsychiatr Dis Treat 9:259-65. 2013
    ..In summary, switching to galantamine from donepezil and addition of memantine in patients with AD receiving donepezil were both safe and meaningful treatment options, and particularly efficacious for suppression of agitation...
  23. ncbi request reprint Relationships between disease progression and serum levels of lipid, urate, creatinine and ferritin in Japanese patients with amyotrophic lateral sclerosis: a cross-sectional study
    Ken Ikeda
    Department of Neurology, Toho University Omori Medical Center, Japan
    Intern Med 51:1501-8. 2012
    ..We aimed to examine the levels of these serological factors and their relationship to disease progression in Japanese ALS patients...
  24. ncbi request reprint Familial amyotrophic lateral sclerosis with a novel G85S mutation of superoxide dismutase 1 gene: clinical features of lower motor neuron disease
    Takanori Takazawa
    Department of Neurology, Toho University Omori Medical Center, Tokyo
    Intern Med 49:183-6. 2010
    ..The patient died at 18 months after clinical onset. Clinical hallmarks of this FALS family indicate that G85S mutation of SOD1 may cause rapidly progressive form of pure lower motor neuron signs...
  25. ncbi request reprint Repeated non-enhancing tumefactive lesions in a patient with a neuromyelitis optica spectrum disorder
    Ken Ikeda
    Department of Neurology, Toho University Omori Medical Center, Japan
    Intern Med 50:1061-4. 2011
    ..Compared to multiple sclerosis (MS), a high frequency of non-enhancing tumefactive lesions is reported in patients with NMO or NMOSD. The absence of GDE in tumefactive lesions could help to differentiate between NMO and MS...
  26. ncbi request reprint [Clinicoradiological studies and frequency of incidental meningiomas on brain check-up]
    Ken Ikeda
    Department of Neurology, PL Tokyo Health Care Center, Japan
    Brain Nerve 60:273-8. 2008
    ..In middle-aged working subjects, incidental rates of asymptomatic meningiomas detected by BC are not uncommon in Japan. We should pay more attention to incidental meningioma when brain MRI is performed in 40-60 years women...
  27. pmc Limb-onset amyotrophic lateral sclerosis patients visiting orthopedist show a longer time-to-diagnosis since symptom onset
    Osamu Kano
    Department of Neurology, Toho University Omori Medical Center, Tokyo, Japan
    BMC Neurol 13:19. 2013
    ..However, little is known about how the choice of physician (i.e., general practitioner, neurologist, etc.) may affect the time it takes for a diagnosis of ALS to be made...
  28. pmc Alleviation of brain hypoperfusion after preventative treatment with lomerizine in an elderly migraineur with aura
    Joe Aoyagi
    Department of Neurology, Mishuku Hospital, 5 33 12 Kamimeguro, Meguroku, Tokyo 153 0051, Japan
    Int J Mol Imaging 2011:782758. 2011
    ..At 3 months after lomerizine medication, brain SPECT showed remarkable increase of rCBF. These SPECT changes of our patient indicated that antimigraine mechanism of lomerizine could contribute to restoration of cerebral hypoperfusion...
  29. ncbi request reprint A distinct phenotype of leg hyperreflexia in a Japanese family with Gerstmann-Sträussler-Scheinker syndrome (P102L)
    Takanori Takazawa
    Department of Neurology, Toho University Omori Medical Center, Tokyo
    Intern Med 49:339-42. 2010
    ..This neurological sign differs from the previously reported clinical expression of Japanese and foreign patients with GSS (P102L). Thus, physicians should pay more attention to phenotypic heterogeneity in this prion disease...
  30. ncbi request reprint Ophthalmoplegia and flaccid paraplegia in a patient with anti-NMDA receptor encephalitis: a case report and literature review
    Yuichi Ishikawa
    Department of Neurology, Toho University Omori Medical Center, Japan
    Intern Med 52:2811-5. 2013
    ..In addition to various encephalitic symptoms, physicians should pay more attention to peripheral nerve damage in patients with anti-NMDAR encephalitis. ..
  31. ncbi request reprint Transient splenial lesion after recovery of cerebral vasoconstriction and posterior reversible encephalopathy syndrome: a case report of eclampsia
    Tokinori Sekine
    Department of Neurology, Toshiba Hospital, Japan
    Intern Med 51:1407-11. 2012
    ..At one month after onset, MRA was normalized. T2-weighted imaging depicted asymptomatic isolated TSL. These radiological changes of the present patient highlighted the serial relationship between PRES, RCV and TSL in eclampsia...
  32. doi request reprint A Case of Superficial Hemisensory Dysfunction due to Operculo-insular Infarction: Radiological Depiction of Thalamocortical Projections to the Secondary Somatosensory Cortex
    Takehisa Hirayama
    Department of Neurology, Toho University Omori Medical Center, Tokyo, Japan
    J Stroke Cerebrovasc Dis 23:187-90. 2014
    ..Thus, the thalamocortical disconnection between the thalamus to the S2 could cause superficial hemisensory dysfunction in the present patient. ..
  33. ncbi request reprint Scopolamine-induced migraine like headache
    Ken Ikeda
    Department of Neurology, Toho University Omori Medical Center, Tokyo
    Intern Med 48:681-5. 2009
    ..Scopolamine butylbromide (SB), a muscarinic receptor antagonist, is used commonly in gastric X-ray examination in the physical check-up in Japan. This study describes clinical features of SB-induced headache...
  34. ncbi request reprint Cheiro-pedal syndrome following pontine infarction
    Osamu Igarashi
    Department of Neurology, Toho University Omori Hospital, 6 11 1 Omorinishi Ota ku, Tokyo 143 8541, Japan
    Neurol Res 27:103-4. 2005
    ..Difference in the threshold may explain the specific sensory pattern in this syndrome. Further examination of the relationship between sensory symptoms and localization on MRI is needed to clarify this syndrome...
  35. ncbi request reprint Rheumatoid leptomeningitis: radiological alteration of cerebral hypoperfusion and subarachnoid lesions
    Ken Ikeda
    Department of Neurology, Toho University Omori Medical Center, Tokyo, Japan
    Intern Med 49:1911-6. 2010
    ..These neuroimages of our patient supported that leptomeningeal inflammation and the adjacent cerebrocortical ischemia could cause encephalitis-like symptoms in RLM patients...
  36. ncbi request reprint Sudden deafness and facial diplegia in Guillain-Barré Syndrome: radiological depiction of facial and acoustic nerve lesions
    Takanori Takazawa
    Department of Neurology, Toho University Omori Medical Center, Japan
    Intern Med 51:2433-7. 2012
    ..Magnetic resonance imaging depicted abnormal enhancement in bilateral facial and acoustic nerves. Physicians should pay more attention to auditory dysfunction in GBS patients with FP...
  37. doi request reprint A case of Vernet syndrome with varicella zoster virus infection
    Kiyokazu Kawabe
    Department of Neurology, Toho University Medical Center Omori Hospital, 6 11 1 Omori nishi Ohta ku, Tokyo, Japan
    J Neurol Sci 270:209-10. 2008
    ..Only a few cases of VS due to VZV have been reported previously. Our case is the first case that detected VZV-DNA in CSF by PCR...
  38. doi request reprint A case of sinus arrest and post-hiccup cough syncope in medullary infarction
    Takanori Takazawa
    Department of Neurology, Toho University Omori Medical Center, Omorinishi, Otaku, Tokyo, Japan
    J Stroke Cerebrovasc Dis 23:566-71. 2014
    ..Thus, physicians should pay more attention to the medullary lesion in patients with arrhythmia and syncope...
  39. ncbi request reprint A case of inferolateral oculomotor fascicular infarction: a review of the clinicoradiological literature
    Ken Miura
    Department of Neurology, Toho University Omori Medical Center, Japan
    Intern Med 51:921-4. 2012
    ..Physicians should pay more attention to oculomotor fascicular infarction in patients with incomplete oculomotor paresis, and spared pupil sphincter and inferior rectus muscles...
  40. ncbi request reprint A case of posterior spinal artery syndrome in the cervical cord: a review of the clinicoradiological literature
    Kiyoko Murata
    Department of Neurology, Toho University Omori Medical Center, Japan
    Intern Med 51:803-7. 2012
    ..T1-hyperintensity and stenosis were found in the right VA at C3-C5. These clinicoradiological findings suggested bilateral PSA syndrome and unilateral VA dissection. This is the fourth report of VA dissection-induced PSA syndrome...
  41. pmc Clinicoradiological changes of brain NK/T cell lymphoma manifesting pure akinesia: a case report
    Susumu Ishihara
    Department of Hematology and Oncology, Toho University Omori Medical Center, Tokyo, Japan
    BMC Neurol 11:137. 2011
    ..Little is known about brain tumor-associated PA. We highlight the clinicoradiological changes in a patient with PA and central nervous system (CNS) metastases of natural killer/T-cell lymphoma (NKTL)...
  42. doi request reprint Optic nerve MRI enhancement in posterior ischaemic optic neuropathy due to internal carotid artery dissection
    Kiyokazu Kawabe
    Department of Neurology, Toho University Omori Medical Center, Tokyo, Japan
    Clin Neurol Neurosurg 112:350-2. 2010
    ..These findings were suggestive of PION associated with ICD. No reports of PION caused by ICD has been reported and his is the first case in which MRI showed optic nerve enhancement due to ICD...
  43. ncbi request reprint The diagnostic interval in amyotrophic lateral sclerosis
    Yasuo Iwasaki
    The Fourth Department of Internal Medicine, Toho University Ohashi Hospital, 2 17 6 Ohashi Meguro ku Tokyo 153 8515, Japan
    Clin Neurol Neurosurg 104:87-9. 2002
    ..8 months in female) than for those with limb-onset (13.7 months in male, 14.8 months in female) in male, respectively, female ALS patients. The diagnosis of ALS was established in all cases by neurologists in our study...
  44. pmc Neurobiology of depression and anxiety in Parkinson's disease
    Osamu Kano
    Department of Neurology, Toho University Omori Medical Center, 6 11 1 Omorinishi, Otaku, Tokyo 143 8541, Japan
    Parkinsons Dis 2011:143547. 2011
    ..Whereas a recent study reported that PD patients with depression and anxiety were associated with different demographic and clinical features...
  45. doi request reprint Age at onset influences on wide-ranged clinical features of sporadic amyotrophic lateral sclerosis
    Naoki Atsuta
    Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Neurol Sci 276:163-9. 2009
    ..To profile the detailed clinical features of sporadic amyotrophic lateral sclerosis (ALS) on large-scale samples in Japan...
  46. doi request reprint Combined treatment of methylprednisolone pulse and memantine hydrochloride prompts recovery from neurological dysfunction and cerebral hypoperfusion in carbon monoxide poisoning: a case report
    Konosuke Iwamoto
    Department of Neurology, Toho University Omori Medical Center, Tokyo
    J Stroke Cerebrovasc Dis 23:592-5. 2014
    ..Further clinical trials are warranted whether such combined therapy can attenuate neurological deficits and cerebral hypoperfusion in patients with CO poisoning...
  47. ncbi request reprint Donepezil-induced Cervical Dystonia in Alzheimer's Disease: A Case Report and Literature Review of Dystonia due to Cholinesterase Inhibitors
    Ken Ikeda
    Department of Neurology, Toho University Omori Medical Center, Japan
    Intern Med 53:1007-10. 2014
    ..Dystonic posture can occur at various timings of ChEI use. Physicians should pay more attention to rapidly progressive cervical dystonia in ChEI-treated AD patients. ..
  48. doi request reprint Neurosyphilis with unilateral optic tract lesion causing homonymous hemianopia
    Kohnosuke Iwamoto
    Department of Neurology, Toho University Medical Center Omori Hospital, Tokyo, Japan
    Neurologist 15:345-6. 2009
    ..Homonymous hemianopia is not a rare symptom. Many causative lesions and pathologies are known, although a unilateral optic tract lesion caused by syphilis is rare...
  49. doi request reprint An exploratory study of the efficacy and safety of yokukansan for neuropsychiatric symptoms in patients with Parkinson's disease
    Taku Hatano
    Department of Neurology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo, Tokyo, 113 8421, Japan
    J Neural Transm 121:275-81. 2014
    ..Each recovered after discontinuation of YKS. YKS improved neuropsychiatric symptoms associated with PD, including hallucinations, anxiety and apathy without severe adverse events and worsening of Parkinsonism...
  50. ncbi request reprint Adult moyamoya disease in the asymptomatic Japanese population
    Ken Ikeda
    Department of Neurology, PL Tokyo Health Care Center, 16 1, Kamiyamacho, Shibuyaku, Tokyo 1500047, Japan
    J Clin Neurosci 13:334-8. 2006
    ..Our standard BC protocol is limited for the detection of moyamoya vessels in the initial stages of MMD. The present study suggests that the radiological features of MMD are asymptomatic in the early stages of the disease...
  51. ncbi request reprint Spinal chronic subdural hematoma in association with anticoagulant therapy: a case report and literature review
    Hiroyuki Jimbo
    Department of Neurosurgery, International University of Health and Welfare, Mita Hospital, Tokyo, Japan
    Spine (Phila Pa 1976) 31:E184-7. 2006
    ..A case of spinal chronic subdural hematoma (SCSDH) in association with anticoagulant therapy was treated surgically...
  52. ncbi request reprint Characteristics of sleep disturbances in Japanese patients with Parkinson's disease. A study using Parkinson's disease sleep scale
    Keisuke Suzuki
    Department of Neurology, Dokkyo Medical University, Tochigi, Japan
    Mov Disord 22:1245-51. 2007
    ..We speculate that the reduction of neurotransmitters involved in the sleep-wakefulness mechanism and degeneration of neurons progress together in parallel with deterioration of motor function...
  53. ncbi request reprint Neutrophil elastase, MIP-2, and TLR-4 expression during human and experimental sepsis
    Hironori Tsujimoto
    Department of Surgery I, National Defense Medical College, Tokorozawa, Saitama, 359 8513, Japan
    Shock 23:39-44. 2005
    ..Neutrophil-derived NE may be associated with increased expression of monocyte/macrophage TLR-4, thereby serving as a positive feedback loop for the inflammatory response among the different cell populations...
  54. pmc Paradoxical effect of IL-18 therapy on the severe and mild Escherichia coli infections in burn-injured mice
    Manabu Kinoshita
    Division of Basic Traumatology, National Defense Medical College Research Institute, National Defense Medical College, Namiki, Tokorozawa, Japan
    Ann Surg 240:313-20. 2004
    ..To investigate the effects of IL-18 therapy on severe and mild bacterial infection after burn injury...
  55. ncbi request reprint Lead optimization of [(S)-gamma-(arylamino)prolyl]thiazolidine focused on gamma-substituent: Indoline compounds as potent DPP-IV inhibitors
    Hiroshi Sakashita
    Chemistry Laboratory, Pharmaceuticals Research Division, Mitsubishi Pharma Corporation, 1000, Kamoshida cho, Aoba ku, Yokohama 227 0033, Japan
    Bioorg Med Chem 15:641-55. 2007
    ..The double restriction effect provides a potent inhibitory activity which compensates for the decrease in activity caused by removing the electrophilic nitrile...
  56. doi request reprint Helicobacter pylori augments growth of gastric cancers via the lipopolysaccharide-toll-like receptor 4 pathway whereas its lipopolysaccharide attenuates antitumor activities of human mononuclear cells
    Kentaro Chochi
    Department of Surgery, National Defense Medical College, Namiki, Tokorozawa, Japan
    Clin Cancer Res 14:2909-17. 2008
    ..We investigated the mechanisms by which H. pylori affects gastric cancer growth and antitumor immunities in the host, focusing on H. pylori-derived lipopolysaccharide (LPS)...
  57. ncbi request reprint Flagellin enhances NK cell proliferation and activation directly and through dendritic cell-NK cell interactions
    Hironori Tsujimoto
    Department of Surgery, University of Florida College of Medicine, Gainesville, FL 32610 0286, USA
    J Leukoc Biol 78:888-97. 2005
    ..These data suggest that flagellin is a capable maturation agent for murine myeloid-derived DCs, and flagellin-activated DCs and flagellin itself are potent inducers of NK cell proliferation...
  58. ncbi request reprint Enhanced interferon-gamma production and bacterial clearance in the liver of splenectomized mice in the models of Escherichia coli injection or intestinal obstruction
    Shin ichi Ikuta
    Department of Surgery I, National Defense Medical College, Saitama 359 8513, Japan
    Shock 21:452-7. 2004
    ..In conclusion, splenectomy does not impair host defense against bacteria infection provided that recovery is sufficient to allow compensatory processes in the liver to occur...