Hiroshi Ihara

Summary

Affiliation: Toho University
Country: Japan

Publications

  1. ncbi request reprint Threshold concentration of unbound bilirubin to induce neurological deficits in a patient with type I Crigler-Najjar syndrome
    H Ihara
    Department of Laboratory Medicine, Toho University, Ohashi Hospital, School of Medicine, Tokyo, Japan
    Ann Clin Biochem 36:347-52. 1999
  2. ncbi request reprint An automated assay for measuring serum ascorbic acid with use of 4-hydroxy-2,2,6,6-tetramethylpiperidinyloxy, free radical and o-phenylenediamine
    H Ihara
    Department of Laboratory Medicine, Ohashi Hospital, School of Medicine, Toho University, 2 17 6 Ohashi, Meguro, Tokyo 1538515, Japan
    Clin Chim Acta 301:193-204. 2000
  3. ncbi request reprint Clinical and analytical evaluation of the simultaneous HPLC assay of retinol and alpha-tocopherol
    H Ihara
    Department of Laboratory Medicine, Ohashi Hospital, Toho University School of Medicine, Meguro, Tokyo, Japan
    J Nutr Sci Vitaminol (Tokyo) 46:257-62. 2000
  4. ncbi request reprint Is skeletal muscle damaged by the oxidative stress following anaerobic exercise?
    H Ihara
    Department of Laboratory Medicine, Ohashi Hospital, Toho University School of Medicine, Tokyo, Japan
    J Clin Lab Anal 15:239-43. 2001
  5. ncbi request reprint Selective use of transthyretin and retinol-binding protein as markers in the postoperative assessment of protein nutritional status
    Hiroshi Ihara
    Department of Laboratory Medicine, Ohashi Hospital, Toho University School of Medicine, 2 17 6 Ohashi, Meguro, Tokyo 183 8515, Japan
    J Clin Lab Anal 17:1-5. 2003
  6. ncbi request reprint Removal of protein-bound and unbound unconjugated bilirubin by perfusion of plasma through an anion-exchange resin in a case of Crigler-Najjar syndrome type I
    Hiroshi Ihara
    Department of Laboratory Medicine, Toho University School of Medicine, 2 17 6 Ohashi, Meguro, Tokyo 1538515, Japan
    Ann Clin Biochem 40:528-33. 2003
  7. doi request reprint Estimation of vitamin B1 excretion in 24-hr urine by assay of first-morning urine
    Hiroshi Ihara
    Department of Laboratory Medicine, Toho University Ohashi Medical Center, Tokyo, Japan
    J Clin Lab Anal 22:291-4. 2008
  8. ncbi request reprint Diurnal variation of biopyrrin excretion in random urine specimens is not corrected by creatinine
    Hiroshi Ihara
    Department of Laboratory Medicine, Toho University Ohashi Medical Center, Meguro, Tokyo, Japan
    J Clin Lab Anal 21:1-6. 2007
  9. ncbi request reprint Recommended dietary allowance for vitamin C in the United States is also applicable to a population of young Japanese women
    Hiroshi Ihara
    Department of Laboratory Medicine, Ohashi Hospital, School of Medicine, Toho University, 2 17 6 Ohashi, Meguro, Tokyo 153 8515, Japan
    J Clin Lab Anal 18:305-8. 2004
  10. ncbi request reprint Stability of fat-soluble and water-soluble vitamins in artificially prepared, vitamin-enriched, lyophilized serum
    Hiroshi Ihara
    Department of Laboratory Medicine, Ohashi Hospital, School of Medicine, Toho University, Tokyo, Japan
    J Clin Lab Anal 18:240-6. 2004

Detail Information

Publications18

  1. ncbi request reprint Threshold concentration of unbound bilirubin to induce neurological deficits in a patient with type I Crigler-Najjar syndrome
    H Ihara
    Department of Laboratory Medicine, Toho University, Ohashi Hospital, School of Medicine, Tokyo, Japan
    Ann Clin Biochem 36:347-52. 1999
    ..The upper limit of unbound bilirubin in such an older patient was nearly the same as that reported for newborns...
  2. ncbi request reprint An automated assay for measuring serum ascorbic acid with use of 4-hydroxy-2,2,6,6-tetramethylpiperidinyloxy, free radical and o-phenylenediamine
    H Ihara
    Department of Laboratory Medicine, Ohashi Hospital, School of Medicine, Toho University, 2 17 6 Ohashi, Meguro, Tokyo 1538515, Japan
    Clin Chim Acta 301:193-204. 2000
    ..994, P<0.001). Ten within-day determinations on a serum pool gave a C.V. <4.3% for both the direct and deproteinization procedures. The between-day assays of the same serum pool over 10 days gave a C.V. of <6.7% by both methods...
  3. ncbi request reprint Clinical and analytical evaluation of the simultaneous HPLC assay of retinol and alpha-tocopherol
    H Ihara
    Department of Laboratory Medicine, Ohashi Hospital, Toho University School of Medicine, Meguro, Tokyo, Japan
    J Nutr Sci Vitaminol (Tokyo) 46:257-62. 2000
    ..We conclude that our normal-phase HPLC method is a stable and reproducible method for alpha-tocopherol and retinol, and is an easy-to-use analytical tool...
  4. ncbi request reprint Is skeletal muscle damaged by the oxidative stress following anaerobic exercise?
    H Ihara
    Department of Laboratory Medicine, Ohashi Hospital, Toho University School of Medicine, Tokyo, Japan
    J Clin Lab Anal 15:239-43. 2001
    ..We suggest that these latter test results following anaerobic exercise exclude the presence of oxidative damage to skeletal muscle...
  5. ncbi request reprint Selective use of transthyretin and retinol-binding protein as markers in the postoperative assessment of protein nutritional status
    Hiroshi Ihara
    Department of Laboratory Medicine, Ohashi Hospital, Toho University School of Medicine, 2 17 6 Ohashi, Meguro, Tokyo 183 8515, Japan
    J Clin Lab Anal 17:1-5. 2003
    ..In these patients, assessments over the next 7-14 days showed persistently low values for albumin, TT, and RBP. We recommend the selective use of TT and RBP for the postoperative assessment of protein nutriture in surgical patients...
  6. ncbi request reprint Removal of protein-bound and unbound unconjugated bilirubin by perfusion of plasma through an anion-exchange resin in a case of Crigler-Najjar syndrome type I
    Hiroshi Ihara
    Department of Laboratory Medicine, Toho University School of Medicine, 2 17 6 Ohashi, Meguro, Tokyo 1538515, Japan
    Ann Clin Biochem 40:528-33. 2003
    ....
  7. doi request reprint Estimation of vitamin B1 excretion in 24-hr urine by assay of first-morning urine
    Hiroshi Ihara
    Department of Laboratory Medicine, Toho University Ohashi Medical Center, Tokyo, Japan
    J Clin Lab Anal 22:291-4. 2008
    ..001) and also with the concentration of total B1 (B1 plus its phosphate esters) in whole blood (r=0.733, P<0.001). We conclude that the B1/Cr ratio in 24-hr urines could be estimated by measuring the ratio in the first-morning urine...
  8. ncbi request reprint Diurnal variation of biopyrrin excretion in random urine specimens is not corrected by creatinine
    Hiroshi Ihara
    Department of Laboratory Medicine, Toho University Ohashi Medical Center, Meguro, Tokyo, Japan
    J Clin Lab Anal 21:1-6. 2007
    ..05), even if their values were corrected by Cr. The amounts of biopyrrins excreted in 24-hr urine specimens were significantly correlated with the 24-hr cortisol excretion (P<0.001) but not to uropepsin (P>0.05)...
  9. ncbi request reprint Recommended dietary allowance for vitamin C in the United States is also applicable to a population of young Japanese women
    Hiroshi Ihara
    Department of Laboratory Medicine, Ohashi Hospital, School of Medicine, Toho University, 2 17 6 Ohashi, Meguro, Tokyo 153 8515, Japan
    J Clin Lab Anal 18:305-8. 2004
    ..This value gave the highest efficiency, sensitivity, negative predictive value, and positive likelihood ratio, and the lowest negative likelihood ratio. Therefore, an RDA of 100 mg/day may be unnecessarily high for young Japanese women...
  10. ncbi request reprint Stability of fat-soluble and water-soluble vitamins in artificially prepared, vitamin-enriched, lyophilized serum
    Hiroshi Ihara
    Department of Laboratory Medicine, Ohashi Hospital, School of Medicine, Toho University, Tokyo, Japan
    J Clin Lab Anal 18:240-6. 2004
    ..Our VES is the first preparation of lyophilized control serum that contains water-soluble and fat-soluble vitamins...
  11. ncbi request reprint Assay values for thiamine or thiamine phosphate esters in whole blood do not depend on the anticoagulant used
    Hiroshi Ihara
    Department of Laboratory Medicine, Ohashi Hospital, Toho University Medical Center, 2 17 6 Ohashi, Meguro, Tokyo, Japan
    J Clin Lab Anal 19:205-8. 2005
    ..In the washed RBCs with any anticoagulant, the concentrations of T, TMP, and TDP expressed either as nmol/L of whole blood or a ratio to hemoglobin were significantly lower (P<0.05) than those in whole blood...
  12. ncbi request reprint Antioxidant capacities of ascorbic acid, uric acid, alpha-tocopherol, and bilirubin can be measured in the presence of another antioxidant, serum albumin
    Hiroshi Ihara
    Department of Laboratory Medicine, Ohashi Hospital, School of Medicine, Toho University, Tokyo, Japan
    J Clin Lab Anal 18:45-9. 2004
    ..However, we found that the magnitude of increase in the AOC of a mixture of HSA and any of these antioxidants was lower than the sum of the AOC of HSA and any one of the following: AA, UA, BR, or TOH (all expressed in micromol/L)...
  13. ncbi request reprint [Vitamin C (ascorbic acid)]
    Hiroshi Ihara
    Department of Laboratory Medicine, Ohashi Hospital, School of Medicine, Toho University
    Nihon Rinsho 62:164-6. 2004
  14. ncbi request reprint Effects of dietary ascorbic acid supplementation on lipid peroxidation and the lipid content in the liver and serum of magnesium-deficient rats
    Satoko Akiyama
    Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture, Tokyo, Japan
    Magnes Res 21:232-6. 2008
    ..These results indicate that Mg deficiency increases the AsA requirement of the body and that AsA supplementation normalizes the serum levels of PCOOH and the liver lipid content in Mg-deficient rats, without altering the Mg status...
  15. ncbi request reprint The assay of ascorbic acid in serum is not affected by physiological concentrations of transferrin and hemoglobin
    Hiroshi Ihara
    Department of Laboratory Medicine, Ohashi Hospital, School of Medicine, Toho University, 2 17 6, Ohashi, Meguro ku, Tokyo 153 8515, Japan
    J Nutr Sci Vitaminol (Tokyo) 49:289-91. 2003
    ..5 h, the magnitude of the decrease in AA due to hemoglobin at physiological concentrations may cause a misleading clinical diagnostic evaluation of low AA concentration...
  16. doi request reprint Commutability of National Institute of Standards and Technology standard reference material 1955 homocysteine and folate in frozen human serum for total folate with automated assays
    Hiroshi Ihara
    Department of Laboratory Medicine, Toho University Ohashi Medical Center, Ohashi, Meguro, Tokyo, Japan
    Ann Clin Biochem 47:541-8. 2010
    ..We also designed so as to reduce the intermethod variability present in different automated methods...
  17. ncbi request reprint [Evidence-based medicine (EBM) for assessment of vitamin deficiency]
    Hiroshi Ihara
    Department of Laboratory Medicine, Ohashi Hospital, Toho University School of Medicine
    Rinsho Byori . 2003
  18. ncbi request reprint Values of water-soluble vitamins in blood and urine of Japanese young men and women consuming a semi-purified diet based on the Japanese Dietary Reference Intakes
    Katsumi Shibata
    School of Human Cultures, The University of Shiga Prefecture, Hikone, Shiga 522 8533, Japan
    J Nutr Sci Vitaminol (Tokyo) 51:319-28. 2005
    ..In future, an experiment with various age groups and re-evaluation by repeated experiments will provide more accurate values...