Yojiro Anzai

Summary

Affiliation: Toho University
Country: Japan

Publications

  1. pmc Function of cytochrome P450 enzymes MycCI and MycG in Micromonospora griseorubida, a producer of the macrolide antibiotic mycinamicin
    Yojiro Anzai
    Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba, Japan
    Antimicrob Agents Chemother 56:3648-56. 2012
  2. ncbi request reprint Phylogenetic affiliation of the pseudomonads based on 16S rRNA sequence
    Y Anzai
    Nippon Roche Research Center, Kamakura, Kanagawa, Japan
    Int J Syst Evol Microbiol 50:1563-89. 2000
  3. doi request reprint Production of rosamicin derivatives in Micromonospora rosaria by introduction of D-mycinose biosynthetic gene with PhiC31-derived integration vector pSET152
    Yojiro Anzai
    Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba 274 8510, Japan
    J Ind Microbiol Biotechnol 36:1013-21. 2009
  4. doi request reprint Gene targeting for O-methyltransferase genes, mycE and mycF, on the chromosome of Micromonospora griseorubida producing mycinamicin with a disruption cassette containing the bacteriophage phi C31 attB attachment site
    Shu ichi Tsukada
    Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba, Japan
    FEMS Microbiol Lett 304:148-56. 2010
  5. doi request reprint Production of a hybrid 16-membered macrolide antibiotic by genetic engineering of Micromonospora sp. TPMA0041
    Ayami Sakai
    Toho University, 2 2 1 Miyama, Funabashi, Chiba 274 8510, Japan
    J Ind Microbiol Biotechnol 39:1693-701. 2012
  6. pmc Functional analysis of MycCI and MycG, cytochrome P450 enzymes involved in biosynthesis of mycinamicin macrolide antibiotics
    Yojiro Anzai
    Faculty of Pharmaceutical Sciences, Toho University, Miyama, Funabashi, Chiba, Japan
    Chem Biol 15:950-9. 2008
  7. pmc Function of cytochrome P450 enzymes RosC and RosD in the biosynthesis of rosamicin macrolide antibiotic produced by Micromonospora rosaria
    Yohei Iizaka
    Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba, Japan
    Antimicrob Agents Chemother 57:1529-31. 2013
  8. ncbi request reprint Organization of the biosynthetic gene cluster for the polyketide macrolide mycinamicin in Micromonospora griseorubida
    Yojiro Anzai
    Faculty of Pharmaceutical Sciences, Toho University, 2 2 1 Miyama, Funabashi, Chiba 274 8510, Japan
    FEMS Microbiol Lett 218:135-41. 2003
  9. ncbi request reprint Hybrid biosynthesis by targeted inactivation of polyketide synthases in the mycinamicin producer, Micromonospora griseorubida
    Yojiro Anzai
    Faculty of Pharmaceutical Sciences, Toho University, 2 2 1 Miyama, Funabashi, Chiba 274 8510, Japan
    J Antibiot (Tokyo) 57:819-22. 2004
  10. ncbi request reprint The targeted inactivation of polyketide synthase mycAV in the mycinamicin producer, Micromonospora griseorubida, and a complementation study
    Yojiro Anzai
    Faculty of Pharmaceutical Sciences, Toho University, 2 2 1 Miyama, Funabashi, Chiba 274 8510, Japan
    FEMS Microbiol Lett 238:315-20. 2004

Collaborators

Detail Information

Publications11

  1. pmc Function of cytochrome P450 enzymes MycCI and MycG in Micromonospora griseorubida, a producer of the macrolide antibiotic mycinamicin
    Yojiro Anzai
    Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba, Japan
    Antimicrob Agents Chemother 56:3648-56. 2012
    ..Moreover, it catalyzed hydroxylation and also epoxidation at C-14 and C-12/13 on these intermediates. However, C-14 on mycinamicin I was not hydroxylated...
  2. ncbi request reprint Phylogenetic affiliation of the pseudomonads based on 16S rRNA sequence
    Y Anzai
    Nippon Roche Research Center, Kamakura, Kanagawa, Japan
    Int J Syst Evol Microbiol 50:1563-89. 2000
    ..The phylogenetic affiliations of these 26 pseudomonads species are shown...
  3. doi request reprint Production of rosamicin derivatives in Micromonospora rosaria by introduction of D-mycinose biosynthetic gene with PhiC31-derived integration vector pSET152
    Yojiro Anzai
    Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba 274 8510, Japan
    J Ind Microbiol Biotechnol 36:1013-21. 2009
    ..The pSETmycinose could be useful for stimulating the production of "unnatural" natural mycinosyl compounds by various actinomycete strains using the bacteriophage PhiC31 att/int system...
  4. doi request reprint Gene targeting for O-methyltransferase genes, mycE and mycF, on the chromosome of Micromonospora griseorubida producing mycinamicin with a disruption cassette containing the bacteriophage phi C31 attB attachment site
    Shu ichi Tsukada
    Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba, Japan
    FEMS Microbiol Lett 304:148-56. 2010
    ..The complemented strains of mycE and mycF recovered the mycinamicin II productivity...
  5. doi request reprint Production of a hybrid 16-membered macrolide antibiotic by genetic engineering of Micromonospora sp. TPMA0041
    Ayami Sakai
    Toho University, 2 2 1 Miyama, Funabashi, Chiba 274 8510, Japan
    J Ind Microbiol Biotechnol 39:1693-701. 2012
    ..The production of 22-O-mycinosyl-izenamicin B(2) (=TMC-016) was increased when propionate, a precursor of methylmalonyl-CoA, was added to the culture broth...
  6. pmc Functional analysis of MycCI and MycG, cytochrome P450 enzymes involved in biosynthesis of mycinamicin macrolide antibiotics
    Yojiro Anzai
    Faculty of Pharmaceutical Sciences, Toho University, Miyama, Funabashi, Chiba, Japan
    Chem Biol 15:950-9. 2008
    ..These reactions require prior dimethylation of 6-deoxyallose to mycinose for effective conversion by the dual function MycG enzyme...
  7. pmc Function of cytochrome P450 enzymes RosC and RosD in the biosynthesis of rosamicin macrolide antibiotic produced by Micromonospora rosaria
    Yohei Iizaka
    Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba, Japan
    Antimicrob Agents Chemother 57:1529-31. 2013
    ..It is proposed that M. rosaria IFO13697 has two pathway branches that lead from the first desosaminyl rosamicin intermediate, 20-deoxo-20-dihydro-12,13-deepoxyrosamicin, to rosamicin...
  8. ncbi request reprint Organization of the biosynthetic gene cluster for the polyketide macrolide mycinamicin in Micromonospora griseorubida
    Yojiro Anzai
    Faculty of Pharmaceutical Sciences, Toho University, 2 2 1 Miyama, Funabashi, Chiba 274 8510, Japan
    FEMS Microbiol Lett 218:135-41. 2003
    ....
  9. ncbi request reprint Hybrid biosynthesis by targeted inactivation of polyketide synthases in the mycinamicin producer, Micromonospora griseorubida
    Yojiro Anzai
    Faculty of Pharmaceutical Sciences, Toho University, 2 2 1 Miyama, Funabashi, Chiba 274 8510, Japan
    J Antibiot (Tokyo) 57:819-22. 2004
  10. ncbi request reprint The targeted inactivation of polyketide synthase mycAV in the mycinamicin producer, Micromonospora griseorubida, and a complementation study
    Yojiro Anzai
    Faculty of Pharmaceutical Sciences, Toho University, 2 2 1 Miyama, Funabashi, Chiba 274 8510, Japan
    FEMS Microbiol Lett 238:315-20. 2004
    ..The feeding culture and the introduction of the complement gene for M7A21 would be powerful tools to perform combinatorial biosynthesis for the production of new macrolide antibiotics...
  11. doi request reprint Characteristics of cesium accumulation in the filamentous soil bacterium Streptomyces sp. K202
    Chikako Kuwahara
    Chemistry Division, Kanagawa Prefectural Institute of Public Health, 1 3 1 Shimomachiya, Chigasaki shi, Kanagawa, Japan
    J Environ Radioact 102:138-44. 2011
    ....