M Yoshizumi

Summary

Affiliation: The University of Tokushima
Country: Japan

Publications

  1. ncbi Quercetin inhibits Shc- and phosphatidylinositol 3-kinase-mediated c-Jun N-terminal kinase activation by angiotensin II in cultured rat aortic smooth muscle cells
    M Yoshizumi
    Department of Pharmacology, The University of Tokushima School of Medicine, Tokushima, Japan
    Mol Pharmacol 60:656-65. 2001
  2. ncbi Stress and vascular responses: atheroprotective effect of laminar fluid shear stress in endothelial cells: possible role of mitogen-activated protein kinases
    Masanori Yoshizumi
    Department of Pharmacology, The University of Tokushima School of Medicine, Tokushima, Japan
    J Pharmacol Sci 91:172-6. 2003
  3. ncbi Src and Cas are essentially but differentially involved in angiotensin II-stimulated migration of vascular smooth muscle cells via extracellular signal-regulated kinase 1/2 and c-Jun NH2-terminal kinase activation
    Moe Kyaw
    Department of Pharmacology, The University of Tokushima School of Medicine, 3 18 15 Kuramoto, Tokushima 770 8503, Japan
    Mol Pharmacol 65:832-41. 2004
  4. ncbi Ebselen attenuates oxidative stress-induced apoptosis via the inhibition of the c-Jun N-terminal kinase and activator protein-1 signalling pathway in PC12 cells
    Masanori Yoshizumi
    Department of Pharmacology, The University of Tokushima School of Medicine, 3 18 15 Kuramoto, Tokushima 770 8503, Japan
    Br J Pharmacol 136:1023-32. 2002
  5. ncbi Quercetin glucuronide prevents VSMC hypertrophy by angiotensin II via the inhibition of JNK and AP-1 signaling pathway
    Masanori Yoshizumi
    Department of Pharmacology, The University of Tokushima School of Medicine, 3 18 15 Kuramoto, Tokushima 770 8503, Japan
    Biochem Biophys Res Commun 293:1458-65. 2002
  6. ncbi BMK1 is activated in glomeruli of diabetic rats and in mesangial cells by high glucose conditions
    Yuki Suzaki
    Department of Pharmacology and Pediatrics, The University of Tokushima School of Medicine, Tokushima, Japan
    Kidney Int 65:1749-60. 2004
  7. ncbi Ebselen inhibits tumor necrosis factor-alpha-induced c-Jun N-terminal kinase activation and adhesion molecule expression in endothelial cells
    Masanori Yoshizumi
    Department of Pharmacology, The University of Tokushima School of Medicine, Tokushima 770 8503, Japan
    Exp Cell Res 292:1-10. 2004
  8. ncbi Endothelin-1-(1-31), a novel vasoactive peptide, increases [Ca2+]i in human coronary artery smooth muscle cells
    M Yoshizumi
    Department of Pharmacology, The University of Tokushima School of Medicine, Kuramoto, Japan
    Eur J Pharmacol 348:305-9. 1998
  9. ncbi Antioxidants inhibit JNK and p38 MAPK activation but not ERK 1/2 activation by angiotensin II in rat aortic smooth muscle cells
    M Kyaw
    Department of Pharmacology, The University of Tokushima School of Medicine, Japan
    Hypertens Res 24:251-61. 2001
  10. ncbi Effects of losartan in combination with or without exercise on insulin resistance in Otsuka Long-Evans Tokushima Fatty rats
    K Ishizawa
    Department of Pharmacology, University of Tokushima School of Medicine, 3-18-15 Kuramoto, 770-8503, Tokushima, Japan
    Eur J Pharmacol 430:359-67. 2001

Collaborators

Detail Information

Publications62

  1. ncbi Quercetin inhibits Shc- and phosphatidylinositol 3-kinase-mediated c-Jun N-terminal kinase activation by angiotensin II in cultured rat aortic smooth muscle cells
    M Yoshizumi
    Department of Pharmacology, The University of Tokushima School of Medicine, Tokushima, Japan
    Mol Pharmacol 60:656-65. 2001
    ..Thus, inhibition of JNK by quercetin may imply its usefulness for the treatment of cardiovascular diseases relevant to VSMC growth...
  2. ncbi Stress and vascular responses: atheroprotective effect of laminar fluid shear stress in endothelial cells: possible role of mitogen-activated protein kinases
    Masanori Yoshizumi
    Department of Pharmacology, The University of Tokushima School of Medicine, Tokushima, Japan
    J Pharmacol Sci 91:172-6. 2003
    ..Understanding the mechanisms by which steady laminar flow regulates JNK activation by cytokines may provide insight into the atheroprotective mechanisms induced by laminar blood flow...
  3. ncbi Src and Cas are essentially but differentially involved in angiotensin II-stimulated migration of vascular smooth muscle cells via extracellular signal-regulated kinase 1/2 and c-Jun NH2-terminal kinase activation
    Moe Kyaw
    Department of Pharmacology, The University of Tokushima School of Medicine, 3 18 15 Kuramoto, Tokushima 770 8503, Japan
    Mol Pharmacol 65:832-41. 2004
    ..These findings suggest that Src and Cas are essentially but differentially involved in Ang II-stimulated migration of VSMC through the activation of ERK1/2 and JNK...
  4. ncbi Ebselen attenuates oxidative stress-induced apoptosis via the inhibition of the c-Jun N-terminal kinase and activator protein-1 signalling pathway in PC12 cells
    Masanori Yoshizumi
    Department of Pharmacology, The University of Tokushima School of Medicine, 3 18 15 Kuramoto, Tokushima 770 8503, Japan
    Br J Pharmacol 136:1023-32. 2002
    ..Thus, inhibition of JNK by ebselen may imply its usefulness for treatment of ischaemic cerebral diseases relevant to neuronal cell death...
  5. ncbi Quercetin glucuronide prevents VSMC hypertrophy by angiotensin II via the inhibition of JNK and AP-1 signaling pathway
    Masanori Yoshizumi
    Department of Pharmacology, The University of Tokushima School of Medicine, 3 18 15 Kuramoto, Tokushima 770 8503, Japan
    Biochem Biophys Res Commun 293:1458-65. 2002
    ..Q3GA would be an active metabolite of quercetin in plasma and may possess a preventing effect for cardiovascular diseases relevant to VSMC growth...
  6. ncbi BMK1 is activated in glomeruli of diabetic rats and in mesangial cells by high glucose conditions
    Yuki Suzaki
    Department of Pharmacology and Pediatrics, The University of Tokushima School of Medicine, Tokushima, Japan
    Kidney Int 65:1749-60. 2004
    ..However, the role of BMK1 in diabetic nephropathy has not been elucidated yet...
  7. ncbi Ebselen inhibits tumor necrosis factor-alpha-induced c-Jun N-terminal kinase activation and adhesion molecule expression in endothelial cells
    Masanori Yoshizumi
    Department of Pharmacology, The University of Tokushima School of Medicine, Tokushima 770 8503, Japan
    Exp Cell Res 292:1-10. 2004
    ..Inhibition of JNK by ebselen may imply its usefulness for the prevention of atherosclerosis relevant to EC activation...
  8. ncbi Endothelin-1-(1-31), a novel vasoactive peptide, increases [Ca2+]i in human coronary artery smooth muscle cells
    M Yoshizumi
    Department of Pharmacology, The University of Tokushima School of Medicine, Kuramoto, Japan
    Eur J Pharmacol 348:305-9. 1998
    ..Since human chymase has been reported to play a role in atherosclerosis, endothelin-1-(1-31) may be one of the candidate substances for its cause...
  9. ncbi Antioxidants inhibit JNK and p38 MAPK activation but not ERK 1/2 activation by angiotensin II in rat aortic smooth muscle cells
    M Kyaw
    Department of Pharmacology, The University of Tokushima School of Medicine, Japan
    Hypertens Res 24:251-61. 2001
    ..Thus, inhibition of MAP kinases by antioxidants may imply their usefulness for relief of cardiovascular diseases...
  10. ncbi Effects of losartan in combination with or without exercise on insulin resistance in Otsuka Long-Evans Tokushima Fatty rats
    K Ishizawa
    Department of Pharmacology, University of Tokushima School of Medicine, 3-18-15 Kuramoto, 770-8503, Tokushima, Japan
    Eur J Pharmacol 430:359-67. 2001
    ..The enhancing effect of angiotensin AT(1) receptor antagonist on skeletal muscle glucose uptake may be attributable to MAP kinase activation or other mechanisms rather than phosphatidylinositol 3-kinase activation...
  11. ncbi Palytoxin: a potent stimulator of catecholamine release from cultured bovine adrenal chromaffin cells
    A Nakanishi
    Department of Pharmacology, Tokushima University School of Medicine, Japan
    Neurosci Lett 121:163-5. 1991
    ..These results indicated that PTX-induced catecholamine release was mediated by activation of Na(+)-dependent, tetrodotoxin (TTX) insensitive voltage-dependent Ca2+ channels...
  12. ncbi Requirement for tyrosine kinase-ERK1/2 signaling in alpha 1 beta 1 integrin-mediated collagen matrix remodeling by rat mesangial cells
    S Kagami
    Department of Pediatrics, School of Medicine, University of Tokushima, Tokushima 770 8503, Japan
    Exp Cell Res 268:274-83. 2001
    ..We therefore conclude that ERK1/2 may serve as a possible target for pharmacological inhibition of pathological collagen matrix formation in GN...
  13. ncbi Mechanism of palytoxin-induced Na+ influx into cultured bovine adrenal chromaffin cells: possible involvement of Na+/H+ exchange system
    M Yoshizumi
    Department of Pharmacology, Tokushima University School of Medicine, Tokushima, Japan
    Neurosci Lett 130:103-6. 1991
    ..These results indicate that an amiloride-sensitive Na+/H+ exchange mechanism is probably involved in PTX-induced, TTX-insensitive Na+ influx that triggers Ca2+ influx and catecholamine secretion from the cells...
  14. ncbi Enhancement by cytochalasin B of ouabain-stimulated catecholamine secretion from cultured bovine adrenal chromaffin cells: possible relation to alteration in Na+/K(+)-pump activity
    K Morita
    Department of Pharmacology, Tokushima University School of Medicine, Japan
    Cell Mol Neurobiol 10:525-37. 1990
    ..Thus, the present study provides an evidence for a possible role of microfilaments as one of the intrinsic factors modulating the plasma membrane functions...
  15. ncbi Inhibitory action of carvedilol, a novel alpha, beta-adrenoceptor antagonist, on catecholamine secretion and calcium influx in cultured bovine adrenal chromaffin cells
    K Morita
    Department of Pharmacology, Tokushima University School of Medicine, Japan
    Biochem Pharmacol 38:4461-5. 1989
    ....
  16. ncbi Electron paramagnetic resonance study on free radical scavenging and/or generating activity of dopamine-4-O-sulfate
    K Kirima
    Department of Pharmacology, The University of Tokushima School of Medicine, Japan
    Chem Pharm Bull (Tokyo) 49:576-80. 2001
    ..Furthermore, dopamine-4-O-sulfate did not react with a strong oxidizing agent, sodium periodate. These results suggest that dopamine-4-O-sulfate has resistance against autoxidation, and seems to be a stable metabolite of dopamine...
  17. ncbi Determination of the levels of novel 31-amino acid endothelins and endothelins in human lungs
    N Okishima
    Department of Pharmacology, School of Medicine, Institute for Enzyme Research, The University of Tokushima, Japan
    Life Sci 68:2073-80. 2001
    ..This method can be utilized to assess the pathophysiological roles of ETs(1-31) in various human organs...
  18. ncbi Potentiation by ouabain of bradykinin-induced catecholamine secretion and calcium influx into cultured bovine adrenal chromaffin cells: evidence for involvement of Na+ influx associated with the bradykinin B2-receptor
    Y Murakumo
    Department of Pharmacology, School of Medicine, University of Tokushima, Japan
    Life Sci 57:PL259-64. 1995
    ..These results indicated that activation of the BK-B2 receptor and inhibition of the Na+ pump both increase the intracellular Na+ level, resulting in increase in Ca2+ influx and CA secretion...
  19. ncbi Lysophosphatidic acid as a stimulator of Na(+)-dependent Ca2+ efflux from adrenal chromaffin cells
    H Houchi
    Department of Pharmacology, School of Medicine, University of Tokushima, Japan
    Life Sci 57:PL205-10. 1995
    ..These results indicate that LPA stimulates extracellular Na(+)-dependent 45Ca2+ efflux from cultured bovine adrenal chromaffin cells, probably through its stimulatory effect on membrane Na+/Ca2+ exchange...
  20. ncbi Regulatory mechanism of calcium efflux from cultured bovine adrenal chromaffin cells induced by extracellular ATP
    H Houchi
    Department of Pharmacology, School of Medicine, University of Tokushima, Japan
    Neurosci Lett 198:177-80. 1995
    ..These results indicate that ATP stimulates extracellular Na(+)-dependent 45Ca2+ efflux from cultured bovine adrenal chromaffin cells, probably through its stimulatory effect on membrane Na+/Ca2+ exchange...
  21. ncbi Signal transduction of reactive oxygen species and mitogen-activated protein kinases in cardiovascular disease
    M Yoshizumi
    Department of Pharmacology, The University of Tokushima School of Medicine, Kuramoto-cho, Tokushima 770-8503, Japan
    J Med Invest 48:11-24. 2001
    ..The pathways responsible for ROS generation in the cardiovascular system may provide novel therapeutic targets...
  22. ncbi Adrenomedullin stimulates calcium efflux from adrenal chromaffin cells in culture: possible involvement of an Na+/Ca2+ exchange mechanism
    H Houchi
    Department of Pharmacology, School of Medicine, The University of Tokushima, Japan
    Life Sci 58:PL 35-40. 1996
    ..These results indicate that adrenomedullin stimulates extracellular Na+-dependent 45Ca2+ efflux from cultured bovine adrenal chromaffin cells, probably through its stimulatory effect on membrane Na+/Ca2+ exchange...
  23. ncbi Collagen synthesis and collagenase activity of cryopreserved heart valves
    M Kano
    Department of Cardiovascular Surgery, The University of Tokushima School of Medicine, Tokushima, Japan
    J Thorac Cardiovasc Surg 122:706-11. 2001
    ..These results imply that the cryopreservation procedure itself may cause the collagen metabolism to be on the degradable side, which will lead to valve failure...
  24. ncbi Malfunction of vascular control in lifestyle-related diseases: formation of systemic hemoglobin-nitric oxide complex (HbNO) from dietary nitrite
    Koichiro Tsuchiya
    Department of Clinical Pharmacology, Subdivision of Clinical Pharmaceutical Sciences, Institute of Health Biosciences, The University of Tokushima Graduate School, 1 78 Sho machi, Tokushima 770 8505, Japan
    J Pharmacol Sci 96:395-400. 2004
    ..Our findings suggest that the intake of nitrite (or nitrate)-rich foods such as vegetables and fruits would alter the systemic HbNO dynamism, resulting in the improvement of cardiovascular diseases...
  25. ncbi Nitrite-derived nitric oxide formation following ischemia-reperfusion injury in kidney
    Masumi Okamoto
    Department of Pharmacology, University of Tokushima School of Medicine, 3-18-15 Kuramoto, Tokushima 770-8503, Japan
    Am J Physiol Renal Physiol 288:F182-7. 2005
    ..Our findings suggest that nitrite can be an alternative source of NO in ischemic kidney and that it binds with hemoglobin and then is spread by the circulation after reperfusion...
  26. ncbi Nitrite is an alternative source of NO in vivo
    Koichiro Tsuchiya
    Department of Pharmacology, The University of Tokushima School of Medicine, Tokushima, Japan
    Am J Physiol Heart Circ Physiol 288:H2163-70. 2005
    ....
  27. ncbi Atheroprotective effects of antioxidants through inhibition of mitogen-activated protein kinases
    Moe Kyaw
    Department of Pharmacology, The University of Tokushima Graduate School of Medicine, 3-18-15 Kuramoto, Tokushima 770-8503, Japan
    Acta Pharmacol Sin 25:977-85. 2004
    ..Thus, further studies are needed to clarify why antioxidants showed beneficial effects in vitro, whereas less satisfactory results were obtained in some clinical conditions...
  28. ncbi Involvement of aldosterone and mineralocorticoid receptors in rat mesangial cell proliferation and deformability
    Akira Nishiyama
    Department of Pharmacology, Kagawa Medical University 1750 1 Ikenobe, Miki cho, Kita gun Kagawa 761 0793, Japan
    Hypertension 45:710-6. 2005
    ..The results indicate that aldosterone directly induces RMC proliferation and deformability through MR and ERK1/2 activation, which may contribute to the pathogenesis of glomerular mesangial injury...
  29. ncbi ERK1/2 activation by angiotensin II inhibits insulin-induced glucose uptake in vascular smooth muscle cells
    Yuki Izawa
    Department of Pharmacology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3 18 15 Kuramoto 770 8503, Japan
    Exp Cell Res 308:291-9. 2005
    ..It is shown that Ang II-induced ERK1/2 activation inhibits insulin-dependent glucose uptake through serine phophorylation of IRS-1 in RASMC...
  30. ncbi A novel Src kinase inhibitor, M475271, inhibits VEGF-induced human umbilical vein endothelial cell proliferation and migration
    Nermin Ali
    Department of Pharmacology, The University of Tokushima Graduate School Institute of Health Biosciences, Japan
    J Pharmacol Sci 98:130-41. 2005
    ..Taken together, these data indicate that M475271 may be a useful candidate for inhibition of endothelial cell proliferation and migration relevant to angiogenesis...
  31. ncbi Antioxidant effects of stereoisomers of N-acetylcysteine (NAC), L-NAC and D-NAC, on angiotensin II-stimulated MAP kinase activation and vascular smooth muscle cell proliferation
    Moe Kyaw
    Department of Pharmacology, The University of Tokushima Graduate School of Medicine, Tokushima 770-8503, Japan
    J Pharmacol Sci 95:483-6. 2004
    ..Our present study indicates the comparable effects of NAC stereoisomers in regulating intracellular GSH and the redox-dependent intracellular signaling mechanisms in VSMC...
  32. ncbi Androgen receptor gene knockout male mice exhibit impaired cardiac growth and exacerbation of angiotensin II-induced cardiac fibrosis
    Yasumasa Ikeda
    Department of Medicine and Bioregulatory Sciences, Institute of Health Biosciences, The University of Tokushima Graduate School, Japan
    J Biol Chem 280:29661-6. 2005
    ..These results suggest that, in male mice, the androgen-AR system participates in normal cardiac growth and modulates cardiac adaptive hypertrophy and fibrosis during the process of cardiac remodeling under hypertrophic stress...
  33. ncbi Aldosterone stimulates collagen gene expression and synthesis via activation of ERK1/2 in rat renal fibroblasts
    Yukiko Nagai
    Research Equipment Center, Kagawa Medical University, Kagawa, Japan
    Hypertension 46:1039-45. 2005
    ..These results suggest that aldosterone stimulates collagen gene expression and synthesis via MR-mediated ERK1/2 activation in renal fibroblasts, which may contribute to the progression of aldosterone-induced tubulointerstitial fibrosis...
  34. ncbi Aldosterone stimulates vascular smooth muscle cell proliferation via big mitogen-activated protein kinase 1 activation
    Keisuke Ishizawa
    Department of Pharmacology, University of Tokushima Graduate School of Medicine, Japan
    Hypertension 46:1046-52. 2005
    ..In addition to the classical steroid activity, rapid nongenomic effects induced by aldosterone may represent an alternative etiology for vascular diseases such as hypertension...
  35. ncbi Transactivation of fetal liver kinase-1/kinase-insert domain-containing receptor by lysophosphatidylcholine induces vascular endothelial cell proliferation
    Yoshiko Fujita
    Department of Pharmacology, The University of Tokushima Graduate School of Medical Sciences, 3 18 15 Kuramoto, Tokushima 770 8503, Japan
    Endocrinology 147:1377-85. 2006
    ..These findings suggest that LPC-induced Flk-1/KDR transactivation via c-Src may have important implications for the progression of atherosclerosis...
  36. ncbi Pramipexole protects against H2O2-induced PC12 cell death
    Yoshiko Fujita
    Department of Pharmacology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, 770-8503, Japan
    Naunyn Schmiedebergs Arch Pharmacol 372:257-66. 2006
    ..These results suggest that pramipexole exerts a protective effect against oxidative stress-induced PC12 cell death in part through an inhibition of JNK and p38 MAP kinase...
  37. ncbi [Intracellular signal transduction of vascular injury in insulin resistance]
    Masanori Yoshizumi
    Nippon Yakurigaku Zasshi 128:147-52. 2006
  38. ncbi The novel Src kinase inhibitor M475271 inhibits VEGF-induced vascular endothelial-cadherin and beta-catenin phosphorylation but increases their association
    Nermin Ali
    Department of Pharmacology, The University of Tokushima Graduate School, Institute of Health Biosciences, Japan
    J Pharmacol Sci 102:112-20. 2006
    ..Although the involvement of other signaling molecules cannot be ruled out, M475271 has potential as a drug for the inhibition of the angiogenesis needed for tumor growth and metastasis...
  39. ncbi Calcium and reactive oxygen species mediated Zn2+ -induced apoptosis in PC12 cells
    Shinji Abe
    Department of Clinical Pharmacy, Tokushima University Hospital, Japan
    J Pharmacol Sci 102:103-11. 2006
    ..Treatment with N-acetyl-L-cysteine blocked (*)OH generation and subsequent cell death. These data indicate that Ca(2+) influx and subsequent (*)OH production are critical events in Zn(2+)-induced toxicity in PC12 cells...
  40. ncbi Big mitogen-activated protein kinase 1 (BMK1)/extracellular signal regulated kinase 5 (ERK5) is involved in platelet-derived growth factor (PDGF)-induced vascular smooth muscle cell migration
    Yuki Izawa
    Department of Pharmacology, The University of Tokushima Graduate School of Medical Sciences, Tokushima, Japan
    Hypertens Res 30:1107-17. 2007
    ..From these findings, it is suggested that BMK1 activation leads to VSMC migration induced by PDGF via Gab1-SHP-2 interaction, and that BMK1-mediated VSMC migration may play a role in the pathogenesis of vascular remodeling...
  41. ncbi Fluid shear stress inhibits TNF-mediated JNK activation via MEK5-BMK1 in endothelial cells
    Lingli Li
    Aab Cardiovascular Research Institute and Department of Medicine, University of Rochester School of Medicine and Dentistry, Box 706, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Biochem Biophys Res Commun 370:159-63. 2008
    ..These results support a key role for the MEK5-BMK1 signaling pathway in the atheroprotective effects of blood flow...
  42. ncbi Hydrogen peroxide stimulates c-Src-mediated big mitogen-activated protein kinase 1 (BMK1) and the MEF2C signaling pathway in PC12 cells: potential role in cell survival following oxidative insults
    Yuki Suzaki
    Department of Pharmacology, Pediatrics, Virology, and Clinical Nutrition, The University of Tokushima School of Medicine, Tokushima 770 8503, Japan
    J Biol Chem 277:9614-21. 2002
    ..These findings suggest that c-Src mediated BMK1 activation by H(2)O(2) may counteract ischemic cellular damage probably through the activation of MEF2C transcription factor...
  43. ncbi The novel role of the C-terminal region of SHP-2. Involvement of Gab1 and SHP-2 phosphatase activity in Elk-1 activation
    Qunhua Huang
    Center for Cardiovascular Research, University of Rochester, Rochester, New York 14642, USA
    J Biol Chem 277:29330-41. 2002
    ..Furthermore, we identified a novel sequence for SHP-2/Gab1 interactions in the C-terminal region of SHP-2...
  44. ncbi Insulin-like growth factor-1 enhances inflammatory responses in endothelial cells: role of Gab1 and MEKK3 in TNF-alpha-induced c-Jun and NF-kappaB activation and adhesion molecule expression
    Wenyi Che
    Center for Cardiovascular Research, University of Rochester, Rochester, NY, USA
    Circ Res 90:1222-30. 2002
    ..Furthermore, the IGF-1-mediated downregulation of Gab1 expression represents a novel mechanism to promote vascular inflammation and atherosclerosis...
  45. ncbi The role of thiol and nitrosothiol compounds in the nitric oxide-forming reactions of the iron-N-methyl-d-glucamine dithiocarbamate complex
    Koichiro Tsuchiya
    Department of Pharmacology, University of Tokushima School of Medicine, Tokushima 770 8503, Japan
    Biochem J 367:771-9. 2002
    ..The present study elucidates the difficulties of utilizing the (MGD)(2)Fe(2+) complex for the quantification of NO in biological samples, especially in vivo...
  46. ncbi Antioxidants inhibit endothelin-1 (1-31)-induced proliferation of vascular smooth muscle cells via the inhibition of mitogen-activated protein (MAP) kinase and activator protein-1 (AP-1)
    Moe Kyaw
    Department of Pharmacology, The University of Tokushima School of Medicine, 3-18-15 Kuramoto, Tokushima 770-8503, Japan
    Biochem Pharmacol 64:1521-31. 2002
    ..The underlying mechanisms of the inhibition of cellular proliferation by antioxidants may be explained, in part, by the inhibition of JNK activation and the resultant inhibition of AP-1-DNA binding...
  47. ncbi Evaluation of systemic blood NO dynamics by EPR spectroscopy: HbNO as an endogenous index of NO
    Kazuyoshi Kirima
    Department of Pharmacology, The University of Tokushima School of Medicine, 3-18-15 Kuramoto, Tokushima 770-8503, Japan
    Am J Physiol Heart Circ Physiol 285:H589-96. 2003
    ..We also demonstrated that temocapril improves abnormalities of NO dynamics in L-NAME-induced endothelial dysfunction rats using the EPR HbNO signal subtraction method...
  48. ncbi Inhibition of tumor necrosis factor-[alpha]-induced SHP-2 phosphatase activity by shear stress: a mechanism to reduce endothelial inflammation
    Nicole Lerner-Marmarosh
    Center for Cardiovascular Research, University of Rochester, NY 14642, USA
    Arterioscler Thromb Vasc Biol 23:1775-81. 2003
    ....
  49. ncbi Enzymatic and nonenzymatic formation of reactive oxygen species from 6-anilino-5,8-quinolinequinone
    Toyoshi Hasegawa
    Department of Pharmacology, The University of Tokushima School of Medicine, 3-18-15 Kuramoto, Tokushima 770-8503, Japan
    Biochim Biophys Acta 1670:19-27. 2004
    ..These results indicate that LY83583 can generate ROS both enzymatically and nonenzymatically, although the enzymatic formation is dominant over the nonenzymatic system in PC12 cells...
  50. ncbi New methods to evaluate endothelial function: Evaluation of endothelial function by hemoglobin-nitric oxide complex using electron paramagnetic resonance spectroscopy
    Koichiro Tsuchiya
    Department of Pharmacology, The University of Tokushima School of Medicine, Kuramoto, Japan
    J Pharmacol Sci 93:417-22. 2003
    ..We also demonstrated that temocapril reduces abnormalities of NO dynamics in the L-NAME (N(omega)-nitro-L-arginine-methylester)-induced endothelial dysfunction of rats using the EPR HbNO signal subtraction method...
  51. ncbi Effects of AT1 receptor blockade on renal injury and mitogen-activated protein activity in Dahl salt-sensitive rats
    Akira Nishiyama
    Department of Pharmacology, Research Equipment Center, Kagawa Medical University, Kagawa, Japan
    Kidney Int 65:972-81. 2004
    ..Here, we examined the effect of angiotensin II type 1 receptor (AT1) receptor blockade on renal injury and MAPK activity in Dahl salt-sensitive (DS) rats...
  52. ncbi Possible contributions of reactive oxygen species and mitogen-activated protein kinase to renal injury in aldosterone/salt-induced hypertensive rats
    Akira Nishiyama
    Department of Pharmacology, Kagawa Medical University, Kagawa, Japan
    Hypertension 43:841-8. 2004
    ..Furthermore, eplerenone and tempol treatments normalized the activities of ERK1/2, JNK, and BMK1. These data suggest that ROS and MAPK play a role in the progression of renal injury induced by chronic elevations in aldosterone...
  53. ncbi Ebselen inhibits p38 mitogen-activated protein kinase-mediated endothelial cell death by hydrogen peroxide
    Nermin Ali
    Department of Pharmacology, The University of Tokushima School of Medicine, 3-18-15 Kuramoto, Tokushima 770-8503, Japan
    Eur J Pharmacol 485:127-35. 2004
    ..Thus, inhibition of p38 MAP kinase by ebselen may imply its usefulness for prevention and/or treatment of endothelial cell dysfunction, which was suggested to be the first step in the development of atherosclerosis...
  54. ncbi The SOD mimetic tempol ameliorates glomerular injury and reduces mitogen-activated protein kinase activity in Dahl salt-sensitive rats
    Akira Nishiyama
    Department of Pharmacology, Kagawa Medical University, Kagawa, Japan
    J Am Soc Nephrol 15:306-15. 2004
    ..These data suggest that reactive oxygen species, generated by NAD(P)H oxidase, contribute to the progression of renal injury through ERK1/ERK2 activation in DS/H hypertensive rats...
  55. ncbi Subtypes of neuronal nicotinic acetylcholine receptors involved in nicotine-induced phosphorylation of extracellular signal-regulated protein kinase in PC12h cells
    Hitoshi Nakayama
    Department of Pharmacology, Nara Medical University School of Medicine, 840 Shijo Chou, Kashihara, Japan
    Neurosci Lett 392:101-4. 2006
    ..These results suggest the involvement of alpha3beta4 nAChRs in ERK phosphorylation in PC12h cells...
  56. ncbi Determination of plasma concentrations of endothelin-1(1-31) and endothelin-1 in healthy subjects and patients with atherosclerosis
    Yuki Suzaki
    Department of Pharmacology, University of Tokushima School of Medicine, Tokushima, Japan
    J Cardiovasc Pharmacol 41:S83-7. 2003
    ..This suggests that endothelin-1(1-31) may have similar physiological significance to endothelin-1 in patients with atherosclerosis...
  57. ncbi SRC tyrosine kinase inhibitor, m475271, suppresses subcutaneous growth and production of lung metastasis via inhibition of proliferation, invasion, and vascularization of human lung adenocarcinoma cells
    Rui Zheng
    Department of Internal Medicine and Molecular Therapeutics, University of Tokushima Graduate School, Tokushima, Japan
    Clin Exp Metastasis 22:195-204. 2005
    ..Therefore, a novel Src tyrosine kinase inhibitor, M475271, might be helpful for controlling the progression of human lung adenocarcinoma...
  58. ncbi Addition of the antioxidant probucol to angiotensin II type I receptor antagonist arrests progressive mesangioproliferative glomerulonephritis in the rat
    Shuji Kondo
    Department of Pediatrics, The Institute of Health Bioscience, The University of Tokushima Graduate School, Kuramoto-cho-3-chome, Tokushima 770-8503, Japan
    J Am Soc Nephrol 17:783-94. 2006
    ..The combination of probucol and candesartan may represent a novel route of therapy for patients with progressive GN...
  59. ncbi The reaction rate of edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one (MCI-186)) with hydroxyl radical
    Shinji Abe
    Department of Pharmacology, The University of Tokushima School of Medicine, Tokushima, Japan
    Chem Pharm Bull (Tokyo) 52:186-91. 2004
    ..The possible mechanisms for oxidation of edaravone were investigated from these findings...
  60. ncbi Effect of sarpogrelate hydrochloride, a 5-HT2 blocker, on insulin resistance in Otsuka Long-Evans Tokushima fatty rats (OLETF rats), a type 2 diabetic rat model
    Eiko Takishita
    Department of Nutrition, School of Medicine, Tokushima University, Tokushima City, Japan
    J Cardiovasc Pharmacol 43:266-70. 2004
    ..A plasma adrenaline level also rose significantly by injection of the 5-HT and was prevented by pretreatment of sarpogrelate. These results indicate that sarpogrelate improves insulin resistance in type 2 diabetic rats...
  61. ncbi Effect of endothelin-1 (1-31) on the renal resistance vessels
    Yuichi Ozawa
    Department of Pharmacolgy, The University of Tokushima School of Medicine, Tokushima, Japan
    J Med Invest 50:87-94. 2003
    ..These results suggest that ET-1(1-31)-induced renal arteriolar vasoconstriction may be mediated by ETA-like receptors...
  62. ncbi Dual effects of endothelin-1 (1-31): induction of mesangial cell migration and facilitation of monocyte recruitment through monocyte chemoattractant protein-1 production by mesangial cells
    Keisuke Ishizawa
    Department of Pharmacology, University of Tokushima School of Medicine, Japan
    Hypertens Res 27:433-40. 2004
    ..Since human chymase has been reported to be involved in glomerular disease, ET-1 (1-31) may be among the mediators...