Masaki Yoshida

Summary

Affiliation: The University of Tokyo
Country: Japan

Publications

  1. ncbi The forefront for novel therapeutic agents based on the pathophysiology of lower urinary tract dysfunction: pathophysiology and pharmacotherapy of overactive bladder
    Masaki Yoshida
    Department of Urology, Kumamoto Hospital of Japan Labor Health and Welfare Organization, 1670 Takehara cho, Yatsushiro City, Kumamoto 866 8533, Japan
    J Pharmacol Sci 112:128-34. 2010
  2. doi Effectiveness of tamsulosin hydrochloride and its mechanism in improving nocturia associated with lower urinary tract symptoms/benign prostatic hyperplasia
    Masaki Yoshida
    Department of Urology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Neurourol Urodyn 29:1276-81. 2010
  3. doi New clinical evidence of silodosin, an α(1A) selective adrenoceptor antagonist, in the treatment for lower urinary tract symptoms
    Masaki Yoshida
    Department of Medical Informatics, Japan Labor Health and Welfare Organization, Kumamoto Rosai Hospital, Japan
    Int J Urol 19:306-16. 2012
  4. pmc Safety and efficacy of silodosin for the treatment of benign prostatic hyperplasia
    Masaki Yoshida
    Department of Medical Informatics, University of Tokyo, Japan
    Clin Interv Aging 6:161-72. 2011
  5. doi Perspectives on overactive bladder in the elderly population
    Masaki Yoshida
    Department of Urology, Kumamoto Hospital of Japan Labor Health and Welfare Organization, 3 30 34 1402 Suizenji, Kumamoto, 862 0950, Japan
    World J Urol 27:729-37. 2009
  6. doi The effects of chronic hyperlipidemia on bladder function in myocardial infarction-prone Watanabe heritable hyperlipidemic (WHHLMI) rabbits
    Masaki Yoshida
    Department of Urology, Kumamoto Hospital of Japan Labor Health and Welfare Organization, Kumamoto, Japan
    Neurourol Urodyn 29:1350-4. 2010
  7. doi Pharmacological effects of solifenacin on human isolated urinary bladder
    Koichi Masunaga
    Department of Urology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Pharmacology 82:43-52. 2008
  8. doi Identification of potential therapeutic targets in hypertension-associated bladder dysfunction
    Makoto Yono
    Department of Urology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    BJU Int 105:877-83. 2010
  9. doi Pharmacological effects of propiverine and its active metabolite, M-1, on isolated human urinary bladder smooth muscle, and on bladder contraction in rats
    Yutaka Sugiyama
    Department of Urology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Int J Urol 15:76-81. 2008
  10. doi Efficacy of solifenacin on nocturia in Japanese patients with overactive bladder: impact on sleep evaluated by bladder diary
    Osamu Yokoyama
    Department of Urology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan
    J Urol 186:170-4. 2011

Collaborators

Detail Information

Publications51

  1. ncbi The forefront for novel therapeutic agents based on the pathophysiology of lower urinary tract dysfunction: pathophysiology and pharmacotherapy of overactive bladder
    Masaki Yoshida
    Department of Urology, Kumamoto Hospital of Japan Labor Health and Welfare Organization, 1670 Takehara cho, Yatsushiro City, Kumamoto 866 8533, Japan
    J Pharmacol Sci 112:128-34. 2010
    ..In this review, the pathophysiology of OAB, especially the role of non-neuronal acetylcholine, is discussed. In addition, new drugs with new action mechanisms will be introduced...
  2. doi Effectiveness of tamsulosin hydrochloride and its mechanism in improving nocturia associated with lower urinary tract symptoms/benign prostatic hyperplasia
    Masaki Yoshida
    Department of Urology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Neurourol Urodyn 29:1276-81. 2010
    ....
  3. doi New clinical evidence of silodosin, an α(1A) selective adrenoceptor antagonist, in the treatment for lower urinary tract symptoms
    Masaki Yoshida
    Department of Medical Informatics, Japan Labor Health and Welfare Organization, Kumamoto Rosai Hospital, Japan
    Int J Urol 19:306-16. 2012
    ..In the present review, we summarize the new clinical evidence for lower urinary tract symptoms associated with benign prostatic hyperplasia and introduce the data supporting the new clinical indications of silodosin...
  4. pmc Safety and efficacy of silodosin for the treatment of benign prostatic hyperplasia
    Masaki Yoshida
    Department of Medical Informatics, University of Tokyo, Japan
    Clin Interv Aging 6:161-72. 2011
    ..This review provides clear evidence in support of the clinical usefulness of silodosin in the treatment of LUTS associated with BPH...
  5. doi Perspectives on overactive bladder in the elderly population
    Masaki Yoshida
    Department of Urology, Kumamoto Hospital of Japan Labor Health and Welfare Organization, 3 30 34 1402 Suizenji, Kumamoto, 862 0950, Japan
    World J Urol 27:729-37. 2009
    ....
  6. doi The effects of chronic hyperlipidemia on bladder function in myocardial infarction-prone Watanabe heritable hyperlipidemic (WHHLMI) rabbits
    Masaki Yoshida
    Department of Urology, Kumamoto Hospital of Japan Labor Health and Welfare Organization, Kumamoto, Japan
    Neurourol Urodyn 29:1350-4. 2010
    ..To evaluate chronic hyperlipidemia on bladder function, we examined the functional and histological changes of the bladder in myocardial infarction-prone Watanabe Heritable Hyperlipidemic (WHHLMI) rabbits...
  7. doi Pharmacological effects of solifenacin on human isolated urinary bladder
    Koichi Masunaga
    Department of Urology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Pharmacology 82:43-52. 2008
    ..The findings support that muscarinic-receptor-inhibitory actions in human bladder mainly contribute to the usefulness of solifenacin as a therapeutic drug for overactive bladder...
  8. doi Identification of potential therapeutic targets in hypertension-associated bladder dysfunction
    Makoto Yono
    Department of Urology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    BJU Int 105:877-83. 2010
    ..To investigate differential gene expression profiles in the bladder of spontaneously hypertensive rat (SHR), as the underlying mechanisms involved in hypertension-associated bladder dysfunction remain to be clarified...
  9. doi Pharmacological effects of propiverine and its active metabolite, M-1, on isolated human urinary bladder smooth muscle, and on bladder contraction in rats
    Yutaka Sugiyama
    Department of Urology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Int J Urol 15:76-81. 2008
    ..To investigate the effects of M-1, a major active metabolite of propiverine on the bladder...
  10. doi Efficacy of solifenacin on nocturia in Japanese patients with overactive bladder: impact on sleep evaluated by bladder diary
    Osamu Yokoyama
    Department of Urology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan
    J Urol 186:170-4. 2011
    ..We compared changes in nocturia and sleep related parameters between the anticholinergic solifenacin and placebo in patients with overactive bladder associated with nocturia...
  11. ncbi Differential effects of prazosin and naftopidil on pelvic blood flow and nitric oxide synthase levels in spontaneously hypertensive rats
    Makoto Yono
    Department of Urology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    J Recept Signal Transduct Res 28:403-12. 2008
    ....
  12. doi Predictive factors for the effect of the α1-D/A adrenoceptor antagonist naftopidil on subjective and objective criteria in patients with neurogenic lower urinary tract dysfunction
    Masayuki Takeda
    Department of Urology, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Yamanashi, Japan
    BJU Int 108:100-7. 2011
    ....
  13. ncbi Effect of tamsulosin hydrochloride on lower urinary tract symptoms and quality of life in patients with benign prostatic hyperplasia. Evaluation using bother score
    Masaki Yoshida
    Department of Urology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Drugs Today (Barc) 43:1-7. 2007
    ..The present study suggests that in addition to the IPSS, the evaluation of bother score for each symptom may be necessary in the management for patients with LUTS suggestive of BPH...
  14. doi Solifenacin as add-on therapy for overactive bladder symptoms in men treated for lower urinary tract symptoms--ASSIST, randomized controlled study
    Osamu Yamaguchi
    Department of Urology, Fukushima Medical University School of Medicine, Fukushima, Japan
    Urology 78:126-33. 2011
    ..To assess the efficacy and safety of solifenacin add-on therapy to tamsulosin in lower urinary tract symptoms (LUTS) men with residual overactive bladder (OAB) symptoms despite tamsulosin monotherapy...
  15. ncbi Molecular mechanisms regulating urogenital expression of nitric oxide synthase in spontaneously hypertensive rats
    Makoto Yono
    Department of Urology, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Life Sci 85:334-8. 2009
    ..Therefore, we identified differential gene expression profiles in SHRs to elucidate the molecular mechanisms regulating urogenital expression of NOS...
  16. ncbi Acetylcholine release from urinary bladder smooth muscles of non-insulin-dependent diabetic rats
    Koichi Miyamae
    Department of Urology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Urol Int 73:74-80. 2004
    ....
  17. ncbi [Evaluation of psychometric properties of Japanese version of international prostate symptom score and BPH impact index]
    Yukio Homma
    Department of Urology, University of Tokyo
    Nihon Hinyokika Gakkai Zasshi 94:560-9. 2003
    ..To evaluate psychometric properties of the Japanese version of International Prostate Symptom Score (IPSS) and BPH Impact Index (BII)...
  18. ncbi Management of detrusor dysfunction in the elderly: changes in acetylcholine and adenosine triphosphate release during aging
    Masaki Yoshida
    Department of Urology, Kumamoto University School of Medicine, Honjo, Kumamoto, Japan
    Urology 63:17-23. 2004
    ..Nonneuronal ACh release may play a key role in the storage phase of the micturition reflex, and this may explain, at least in part, the effectiveness of antimuscarinic agents for the treatment of OAB...
  19. ncbi Randomized, double-blind, placebo- and propiverine-controlled trial of the once-daily antimuscarinic agent solifenacin in Japanese patients with overactive bladder
    Osamu Yamaguchi
    Department of Urology, Fukushima Medical University School of Medicine, Fukushima, Japan
    BJU Int 100:579-87. 2007
    ..To compare solifenacin succinate (5 and 10 mg once-daily) to placebo and propiverine hydrochloride (20 mg once-daily), respectively, in Japanese patients with overactive bladder syndrome (OAB)...
  20. ncbi Tadalafil once daily for lower urinary tract symptoms suggestive of benign prostatic hyperplasia: a randomized placebo- and tamsulosin-controlled 12-week study in Asian men
    Osamu Yokoyama
    Department of Urology, Faculty of Medical Science, University of Fukui, Fukui, Japan
    Int J Urol 20:193-201. 2013
    ..To examine the efficacy and safety of tadalafil in Asian men with lower urinary tract symptoms suggestive of benign prostatic hyperplasia...
  21. doi Delivery of DNA into bladder via electroporation
    Masaki Yoshida
    Department of Urology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Methods Mol Biol 423:249-57. 2008
    ..These results suggest that EP is a useful technique for in vivo gene transfer into rat bladder smooth muscles, and that the nNOS gene transferred by this procedure functionally expresses and contributes to NO production...
  22. doi Assessment of overactive bladder symptoms: comparison of 3-day bladder diary and the overactive bladder symptoms score
    Yukio Homma
    Department of Urology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Urology 77:60-4. 2011
    ..To compare the Overactive Bladder Symptom Score (OABSS) and a bladder diary as a tool for assessing symptoms of overactive bladder (OAB)...
  23. doi Region and age dependent differences in alpha(1)-adrenergic responsiveness of rat seminal vesicle and vas deferens
    Makoto Yono
    Department of Urology, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Eur J Pharmacol 587:291-5. 2008
    ....
  24. ncbi Pharmacological effects of darifenacin on human isolated urinary bladder
    Koichi Miyamae
    Department of Urology, Kumamoto University School of Medicine, Kumamoto, Japan
    Pharmacology 69:205-11. 2003
    ..These findings indicate that darifenacin is a potent antagonist at the M(3) receptor and support its use as a treatment for overactive bladder...
  25. ncbi Electroporation-mediated muscarinic M3 receptor gene transfer into rat urinary bladder
    Masayuki Otani
    Department of Urology, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Int J Urol 11:1001-8. 2004
    ....
  26. ncbi Prostaglandin E2 release from isolated bladder strips in rats with spinal cord injury
    Koichi Masunaga
    Department of Urology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Int J Urol 13:271-6. 2006
    ..It has been reported that prostaglandins (PG) act as local modulators of reflex micturition in pathological conditions. In the present study, we measured the amount of PGE2 release from the bladder of chronic SCI rats...
  27. ncbi Effects of diabetes on nitric oxide-mediated relaxations in male rat corpus cavernosum smooth muscle
    Tomohiro Kuwahara
    Department of Urology, Kumamoto University School of Medicine, Honjo, Kumamoto, Japan
    Urol Int 71:399-407. 2003
    ..We evaluated the effects of diabetes on nitric oxide-mediated relaxations and nitric oxide synthase activity in male rat corpus cavernosum smooth muscles...
  28. ncbi Basic and clinical aspects of non-neuronal acetylcholine: expression of non-neuronal acetylcholine in urothelium and its clinical significance
    Masaki Yoshida
    Department of Urology, Graduate School of Medical Science, Kumamoto University, Japan
    J Pharmacol Sci 106:193-8. 2008
    ..It is suggested that the non-neuronal cholinergic system may contribute to the physiology and pathophysiology of human bladder. We also discussed the clinical significance of the non-neuronal cholinergic system in human bladder...
  29. doi Ejaculation disorder is associated with increased efficacy of silodosin for benign prostatic hyperplasia
    Yukio Homma
    Department of Urology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Urology 76:1446-50. 2010
    ..To provide clinical evidence that ejaculation disorder caused by selective alpha(1A)-blockers may be associated with larger symptomatic improvements in patients with benign prostatic hyperplasia...
  30. ncbi Change in acetylcholine release from rat bladder with partial outlet obstruction
    Shigetaka Murakami
    Department of Urology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    BJU Int 101:633-9. 2008
    ....
  31. ncbi [Bilateral pheochromocytomas with von Hippel-Lindau disease: a case report]
    Koichi Masunaga
    Department of Urology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Nihon Hinyokika Gakkai Zasshi 98:843-7. 2007
    ..This is the eleventh case of bilateral pheochromocytomas with VHL disease reported in Japanese literatures...
  32. ncbi Short- and long-term effects of silodosin, a selective alpha 1A-adrenoceptor antagonist, on ejaculatory function in rats
    Makoto Yono
    Department of Urology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    BJU Int 103:1680-5. 2009
    ....
  33. ncbi Pharmacological effects of KRP-197 on the human isolated urinary bladder
    Shigetaka Murakami
    Department of Urology, Kumamoto University School of Medicine, Honjo, Kumamoto, Japan
    Urol Int 71:290-8. 2003
    ..The findings suggest the usefulness of KRP-197 as a therapeutic drug for an overactive bladder with symptoms of frequency, urgency, and urge incontinence...
  34. ncbi Clinical guideline for male lower urinary tract symptoms
    Yukio Homma
    Department of Urology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Int J Urol 16:775-90. 2009
    ..Treatment with anticholinergic agents should be reserved only for urologists, considering the risk of urinary retention. The present guideline should help urologists and especially non-urologists treat men with LUTS...
  35. ncbi Silodosin, a new alpha1A-adrenoceptor-selective antagonist for treating benign prostatic hyperplasia: results of a phase III randomized, placebo-controlled, double-blind study in Japanese men
    Kazuki Kawabe
    Department of Urology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    BJU Int 98:1019-24. 2006
    ..To verify the efficacy and safety of the new alpha1A-adrenoceptor-selective antagonist silodosin compared with tamsulosin and placebo in patients with lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH)...
  36. doi A randomized, double-blind, placebo- and propiverine-controlled trial of the novel antimuscarinic agent imidafenacin in Japanese patients with overactive bladder
    Yukio Homma
    Department of Urology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Int J Urol 16:499-506. 2009
    ..To compare the efficacy and tolerability of imidafenacin, a novel antimuscarinic agent, with propiverine and a placebo in Japanese patients with overactive bladder (OAB)...
  37. ncbi Defining overactive bladder as hypersensitivity
    Osamu Yamaguchi
    Department of Urology, Fukushima Medical University, Fukushima, Japan
    Neurourol Urodyn 26:904-7. 2007
    ..This hypersensitivity was observed in our patients regardless of urgency episodes. We therefore hypothesized that OAB may be more accurately defined as a hypersensitivity disorder rather than a syndrome characterized by urgency...
  38. ncbi Non-neuronal cholinergic system in human bladder urothelium
    Masaki Yoshida
    Department of Urology, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan
    Urology 67:425-30. 2006
    ..To evaluate the non-neuronal cholinergic system in the isolated human bladder. Recently, several reports have demonstrated that non-nerve-evoked acetylcholine (ACh) release may contribute to various pathophysiologic conditions...
  39. pmc Effects of doxazosin on blood flow and mRNA expression of nitric oxide synthase in the spontaneously hypertensive rat genitourinary tract
    Makoto Yono
    Department of Urology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Life Sci 81:218-22. 2007
    ..These findings may provide insight into the beneficial effects of alpha(1)-adrenoceptor antagonists, on prostate, bladder and penile function, when used to treat symptoms of BPH and elevated blood pressure...
  40. ncbi Silodosin, a novel selective alpha 1A-adrenoceptor selective antagonist for the treatment of benign prostatic hyperplasia
    Masaki Yoshida
    Graduate School of Kumamoto University, Department of Urology, Graduate School of Medical Sciences, Honjo, Kumamoto 860 8556, Japan
    Expert Opin Investig Drugs 16:1955-65. 2007
    ..This article reviews preclinical and clinical data of silodosin, and introduces the usefulness of the drug for treatment of benign prostatic hyperplasia patients...
  41. ncbi [Case report of calcifying fibrous pseudotumor of the adrenal grand]
    Tomoko Kuwata
    Department of Urology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Nihon Hinyokika Gakkai Zasshi 99:48-51. 2008
    ..Our case seems to be the first case of CFP to be published in the Japanese literature...
  42. doi Core Lower Urinary Tract Symptom score (CLSS) questionnaire: a reliable tool in the overall assessment of lower urinary tract symptoms
    Yukio Homma
    Department of Urology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Int J Urol 15:816-20. 2008
    ..To identify the symptoms of higher relevance in patients complaining of lower urinary tract symptoms (LUTS)...
  43. ncbi Symptom assessment tool for overactive bladder syndrome--overactive bladder symptom score
    Yukio Homma
    Department of Urology, Japan Red Cross Medical Center, Tokyo, Japan
    Urology 68:318-23. 2006
    ..Overactive bladder (OAB) is a common symptom syndrome with urgency, urinary frequency, and urgency incontinence. To collectively express OAB symptoms, we developed the overactive bladder symptom score (OABSS)...
  44. ncbi Immunohistochemical detection of advanced glycation end products in human bladder with specific monoclonal antibody
    Kenshi Matsumoto
    Department of Urology, Kumamoto University Graduate School of Medicine, Kumamoto, Japan
    Int J Urol 16:402-5; discussion 405-6. 2009
    ..To investigate the accumulation of advanced glycation end products (AGE) in human bladder...
  45. ncbi [Linguistic validation of Japanese version of International Prostate Symptom Score and BPH impact index]
    Yukio Homma
    Department of Urology, University of Tokyo
    Nihon Hinyokika Gakkai Zasshi 93:669-80. 2002
    ..To evaluate linguistic validity of the Japanese version of International Prostate Symptom Score (IPSS) and BPH Impact Index (BII)...
  46. ncbi Voiding and incontinence frequencies: variability of diary data and required diary length
    Yukio Homma
    Department of Urology, Tokyo University, Tokyo, Japan
    Neurourol Urodyn 21:204-9. 2002
    ..However, the diary length should be extended in a patient with rarer events of incontinence, and it should be shortened for those who are incontinent more often or who are diagnosed with voiding frequency only...
  47. doi Expression of two isozymes of acyl-coenzyme A: cholesterol acyltransferase-1 and -2 in clear cell type renal cell carcinoma
    Kenshi Matsumoto
    Department of Urology, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Honjo, Kumamoto, Japan
    Int J Urol 15:166-70. 2008
    ..The present study investigated the expression of acyl-coenzyme A: cholesterol acyltransferase-1 (ACAT-1) and -2 in clear cell type renal cell carcinoma (RCC)...
  48. ncbi Effects of castration on nitric oxide-mediated relaxations in male rat corpus cavernosum smooth muscle
    Yoshihiro Wada
    Department of Urology, Kumamoto University School of Medicine, Kumamoto, Japan
    Urol Int 70:62-9. 2003
    ..The effects of castration on nitric oxide- mediated relaxations and nitric oxide synthase activity in male rat corpus cavernosum smooth muscles...
  49. ncbi Chemohormonal therapy as primary treatment for metastatic prostate cancer: a randomized study of estramustine phosphate plus luteinizing hormone-releasing hormone agonist versus flutamide plus luteinizing hormone-releasing hormone agonist
    Masanori Noguchi
    Department of Urology, Kurume University School of Medicine, Kurume, Japan
    Int J Urol 11:103-9. 2004
    ....
  50. ncbi Transcatheter arterial embolization therapy for a hypoplastic pelvic kidney with a single vaginal ectopic ureter to control incontinence: the usefulness of three-dimensional CT angiography using multidetector-row helical CT
    Kouichi Kudoh
    Department of Radiology, Kumamoto University School of Medicine, Kumamoto, Japan
    Cardiovasc Intervent Radiol 26:479-81. 2003
    ..For this intervention, CT angiography was useful for detecting the corresponding renal artery of the hypoplastic kidney...
  51. ncbi [Pharmacological analysis of neurotransmitters contributing to lower urinary tract function]
    Masaki Yoshida
    Department of Urology, Kumamoto University School of Medicine, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Nihon Yakurigaku Zasshi 121:307-16. 2003
    ..These data may reveal physiological or pathological neurotransmitter control of lower urinary tract function and give us useful information for clinical intervention to treat lower urinary tract symptoms...