Research Topics
Genomes and Genes | Takashi YamauchiSummaryAffiliation: The University of Tokushima Country: Japan Publications
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Publications
Molecular constituents and phosphorylation-dependent regulation of the post-synaptic densityTakashi Yamauchi
Department of Biochemistry, Faculty of Pharmaceutical Sciences, The University of Tokushima, Shomachi 1, Tokushima 770 8505, Japan
Mass Spectrom Rev 21:266-86. 2002..The present review focuses on the molecular properties of PSD proteins, and substrates of protein kinases and their regulation by phosphorylation in order to understand the role of PSD in synaptic plasticity...- Neuronal Ca2+/calmodulin-dependent protein kinase II--discovery, progress in a quarter of a century, and perspective: implication for learning and memoryTakashi Yamauchi
Department of Biochemistry, Graduate School of Pharmaceutical Sciences, University of Tokushima, Shomachi 1, Tokushima 770 8585, Japan
Biol Pharm Bull 28:1342-54. 2005..This review presents the molecular structure, properties and functions of CaM kinase II, as a major component of neurons, based mainly developed on findings made in our laboratory... - Development and specific induction of apoptosis of cultured cell models overexpressing human tau during neural differentiation: Implication in Alzheimer's diseaseMariko Tsukane
Department of Biochemistry, Institute of Health Biosciences and Graduate School of Pharmaceutical Sciences, University of Tokushima, Shomachi 1, Tokushima 770 8505, Japan
Anal Biochem 360:114-22. 2007..These cells are useful for monitoring the apoptosis by abundant tau and may be applied to investigate the molecular mechanism of apoptosis resembling AD... - Molecular constituents of the postsynaptic density fraction revealed by proteomic analysis using multidimensional liquid chromatography-tandem mass spectrometryYoshiyuki Yoshimura
Department of Biochemistry, Faculty of Pharmaceutical Sciences, The University of Tokushima, Shomachi 1, Tokushima, Japan
J Neurochem 88:759-68. 2004..These results provide basic data on a major protein set associated with the PSD and a basis for future functional studies of this important neural machinery... - Ca2+/calmodulin-dependent protein kinase II mediates apoptosis of P19 cells expressing human tau during neural differentiation with retinoic acid treatmentMariko Tsukane
Department of Biochemistry, Institute of Health Biosciences and Graduate School of Pharmaceutical Sciences, University of Tokushima, Tokushima, Japan
J Enzyme Inhib Med Chem 24:365-71. 2009..These results indicated that CaM kinase II was involved in the apoptosis of tau/P19 cells induced by RA treatment... - Rat leucine-rich protein binds and activates the promoter of the beta isoform of Ca2+/calmodulin-dependent protein kinase II geneNagahiro Ochiai
Department of Biochemistry, Institute of Health Biosciences and Graduate School of Pharmaceutical Sciences, The University of Tokushima, Shomachi 1, Tokushima 770 8505, Japan
Neurosci Res 58:67-76. 2007..These results indicate that rLRP157 is one of the proteins binding to, and regulating the activity of, the promoter of beta CaM kinase II... - Increase in apoptosis with neural differentiation and shortening of the lifespan of P19 cells overexpressing tauMariko Tsukane
Department of Biochemistry, Graduate School of Pharmaceutical Sciences, University of Tokushima, Shomachi 1, Tokushima 770-8505, Japan
Neurochem Int 48:243-54. 2006..These observations suggested that tau affects RA signaling in apoptosis and lifespan during the neural differentiation induced by RA treatment... - [Molecular mechanism of learning and memory based on the research for Ca2+/calmodulin-dependent protein kinase II]Takashi Yamauchi
Institute of Health Biosciences, Graduate School of Pharmaceutical Sciences, The University of Tokushima, Japan
Yakugaku Zasshi 127:1173-97. 2007..This review presents molecular structure, properties and functions of CaM kinase II, as a major component of neuron, which are mainly developed in our laboratory... 
Domain structure responsible for the different properties between alpha and beta Ca2+/calmodulin-dependent protein kinase II analyzed by their chimera enzymesAkiko Deguchi
Department of Biochemistry, Institute of Health Biosciences and Graduate School of Pharmaceutical Sciences, University of Tokushima, Tokushima, Japan
Brain Res 1238:1-11. 2008..These results indicated that the structure of exons 10 and 11 and exons 1 and 2 modified the properties of CaM kinase II holoenzyme...- [Molecular mechanism of the regulation of neuronal function based on Ca2+/calmodulin-dependent protein kinase II]Takashi Yamauchi
Institute of Health Biosciences, Graduate School of Pharmaceutical Sciences, The University of Tokushima, Shomachi 1, Tokushima 770-8505, Japan
Seikagaku 78:840-52. 2006 
Proteomic alteration in gastic adenocarcinomas from Japanese patientsTakahiro Yoshihara
Department of Medicinal Biotechnology, Institute for Medicinal Resources, Graduate School of Pharmaceutical Sciences, The University of Tokushima, 1 78 Sho machi, Tokushima 770 8505, Japan
Mol Cancer 5:75. 2006....- VDAC1, having a shorter N-terminus than VDAC2 but showing the same migration in an SDS-polyacrylamide gel, is the predominant form expressed in mitochondria of various tissuesTakenori Yamamoto
Institute for Genome Research, University of Tokushima, Kuramotocho-3, Tokushima 770-8503, Japan
J Proteome Res 5:3336-44. 2006..As a result, the signal intensity of the spot representing VDAC1 was the highest, and thus, VDAC1 was concluded to be the most abundantly expressed of the three VDAC isoforms in mammalian mitochondria... - Overexpression of tau leads to the stimulation of neurite outgrowth, the activation of caspase 3 activity, and accumulation and phosphorylation of tau in neuroblastoma cells on cAMP treatmentChihiro Yoshizaki
Department of Biochemistry, Graduate School of Pharmaceutical Sciences, The University of Tokushima, Shomachi 1, Tokushima 770-8505, Japan
Neurosci Res 49:363-71. 2004..These observations have implications for the cellular causes of Alzheimer's disease where the accumulation and mislocation of tau occur concomitant with neuronal degeneration... - Identification of protein substrates of Ca(2+)/calmodulin-dependent protein kinase II in the postsynaptic density by protein sequencing and mass spectrometryYoshiyuki Yoshimura
Department of Biochemistry, Faculty of Pharmaceutical Sciences, The University of Tokushima, Shomachi 1, Tokushima, 770 8505, Japan
Biochem Biophys Res Commun 290:948-54. 2002..We found 6 proteins not previously known to be substrates of CaM kinase II, namely PSD95-associated protein, SAP97, TOAD-64, TNF receptor-associated protein, insulin-receptor tyrosine kinase 58/53 kDa substrate, and homer 1b... - Interaction of Arc with CaM kinase II and stimulation of neurite extension by Arc in neuroblastoma cells expressing CaM kinase IIHitomi Donai
Department of Biochemistry, Faculty of Pharmaceutical Sciences, The University of Tokushima, Shomachi 1, Tokushima 770-8505, Japan
Neurosci Res 47:399-408. 2003..The growth of neurites by Arc was completely blocked by treatment with KN62, an inhibitor of CaM kinases. These results indicated that Arc potentiated the action of CaM kinase II for neurite extension... - Phosphorylation of tau protein to sites found in Alzheimer's disease brain is catalyzed by Ca2+/calmodulin-dependent protein kinase II as demonstrated tandem mass spectrometryYoshiyuki Yoshimura
Department of Biochemistry, Faculty of Pharmaceutical Sciences, The University of Tokushima, Shomachi 1, Tokushima 770-8505, Japan
Neurosci Lett 353:185-8. 2003..Non-fetal-type phosphorylation may produce PHF-tau. These results suggested that CaMKII is involved in the phosphorylation of tau in Alzheimer's disease brain... - Neuronal cell type-specific promoter of the alpha CaM kinase II gene is activated by Zic2, a Zic family zinc finger proteinTakumi Sakurada
Department of Biochemistry, Graduate School of Pharmaceutical Sciences, The University of Tokushima, Shomachi 1, Tokushima 770 8505, Japan
Neurosci Res 53:323-30. 2005..These results indicated that Zic2 was one of the proteins binding to, and regulating the activity of, the promoter of alpha CaM kinase II... - Interaction of LDL receptor-related protein 4 (LRP4) with postsynaptic scaffold proteins via its C-terminal PDZ domain-binding motif, and its regulation by Ca/calmodulin-dependent protein kinase IIQing Bao Tian
Department of Neuroplasticity, Institute on Ageing and Adaptation, Shinshu University Graduate School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
Eur J Neurosci 23:2864-76. 2006..These findings suggest a postsynaptic role for LRP4, a putative endocytic multiligand receptor, and a mechanism in which CaMKII regulates PDZ-dependent protein-protein interactions and receptor dynamics... - Regulation of exocytosis through Ca2+/ATP-dependent binding of autophosphorylated Ca2+/calmodulin-activated protein kinase II to syntaxin 1AAkihiro Ohyama
Department of Molecular and Cellular Neurobiology, Gunma University School of Medicine, Maebashi, Gunma 371 8511, Japan
J Neurosci 22:3342-51. 2002..These results indicate that the Ca2+/ATP-dependent binding of CaMKII to syntaxin is an important process in the regulation of exocytosis... - Ubiquitin-mediated stress response in the spinal cord after transient ischemiaTakashi Yamauchi
Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka, 565 0871, Japan
Stroke 39:1883-9. 2008..In the present study, we investigated the expression of ubiquitin system molecules and discussed the relationship between the vulnerability and the ubiquitin system after transient ischemia in the spinal cord... - Impact of the endoplasmic reticulum stress response in spinal cord after transient ischemiaTakashi Yamauchi
Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka, 565 0871, Japan
Brain Res 1169:24-33. 2007..In the present study, we investigate the expression of ER stress-related molecules and discuss the relationship between neuronal vulnerability and ER stress after transient ischemia in the spinal cord... - Identification of Tau and MAP2 as novel substrates of Rho-kinase and myosin phosphataseMutsuki Amano
Department of Cell Pharmacology, Graduate School of Medicine, Nagoya University, Aichi, Japan
J Neurochem 87:780-90. 2003..Thus, it is likely that the Rho-kinase/MBS pathway regulates not only the actin-myosin system but also microtubule dynamics... - ONO-5046 attenuation of delayed motor neuron death and effect on the induction of brain-derived neurotrophic factor, phosphorylated extracellular signal-regulated kinase, and caspase3 after spinal cord ischemia in rabbitsTakashi Yamauchi
Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Osaka, Japan
J Thorac Cardiovasc Surg 131:644-50. 2006..ONO-5046 may be a strong candidate for use as a therapeutic agent in the treatment of ischemic spinal cord injury... - Inhibitory role of endophilin 3 in receptor-mediated endocytosisHiroko Sugiura
Department of Neuropharmacology, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Tokyo 183-8526, Japan
J Biol Chem 279:23343-8. 2004..These results indicate that Endo3 may act as a negative regulator of clathrin-mediated endocytosis in brain neurons... - Expression of reelin in the dorsal cochlear nucleus of the mouseYuka Takaoka
Division of Anatomy and Neurobiology, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
Brain Res Dev Brain Res 159:127-34. 2005..The present findings imply that Reelin may have some roles in the formation of laminar structures of the DCN... - Neuroprotective effects of activated protein C through induction of insulin-like growth factor-1 (IGF-1), IGF-1 receptor, and its downstream signal phosphorylated serine-threonine kinase after spinal cord ischemia in rabbitsTakashi Yamauchi
Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Osaka, Japan
Stroke 37:1081-6. 2006..CONCLUSIONS: These results indicate that induction of IGF-1, IGF-1 receptor, and p-Akt might partially explain the neuroprotective effects of APC after transient spinal cord ischemia in rabbit...