Takashi Yamauchi

Summary

Affiliation: The University of Tokushima
Country: Japan

Publications

  1. ncbi request reprint Molecular constituents and phosphorylation-dependent regulation of the post-synaptic density
    Takashi Yamauchi
    Department of Biochemistry, Faculty of Pharmaceutical Sciences, The University of Tokushima, Shomachi 1, Tokushima 770 8505, Japan
    Mass Spectrom Rev 21:266-86. 2002
  2. ncbi request reprint Neuronal Ca2+/calmodulin-dependent protein kinase II--discovery, progress in a quarter of a century, and perspective: implication for learning and memory
    Takashi Yamauchi
    Department of Biochemistry, Graduate School of Pharmaceutical Sciences, University of Tokushima, Shomachi 1, Tokushima 770 8585, Japan
    Biol Pharm Bull 28:1342-54. 2005
  3. ncbi request reprint Development and specific induction of apoptosis of cultured cell models overexpressing human tau during neural differentiation: Implication in Alzheimer's disease
    Mariko Tsukane
    Department of Biochemistry, Institute of Health Biosciences and Graduate School of Pharmaceutical Sciences, University of Tokushima, Shomachi 1, Tokushima 770 8505, Japan
    Anal Biochem 360:114-22. 2007
  4. ncbi request reprint Molecular constituents of the postsynaptic density fraction revealed by proteomic analysis using multidimensional liquid chromatography-tandem mass spectrometry
    Yoshiyuki Yoshimura
    Department of Biochemistry, Faculty of Pharmaceutical Sciences, The University of Tokushima, Shomachi 1, Tokushima, Japan
    J Neurochem 88:759-68. 2004
  5. ncbi request reprint Ca2+/calmodulin-dependent protein kinase II mediates apoptosis of P19 cells expressing human tau during neural differentiation with retinoic acid treatment
    Mariko Tsukane
    Department of Biochemistry, Institute of Health Biosciences and Graduate School of Pharmaceutical Sciences, University of Tokushima, Tokushima, Japan
    J Enzyme Inhib Med Chem 24:365-71. 2009
  6. ncbi request reprint Rat leucine-rich protein binds and activates the promoter of the beta isoform of Ca2+/calmodulin-dependent protein kinase II gene
    Nagahiro Ochiai
    Department of Biochemistry, Institute of Health Biosciences and Graduate School of Pharmaceutical Sciences, The University of Tokushima, Shomachi 1, Tokushima 770 8505, Japan
    Neurosci Res 58:67-76. 2007
  7. ncbi request reprint Increase in apoptosis with neural differentiation and shortening of the lifespan of P19 cells overexpressing tau
    Mariko Tsukane
    Department of Biochemistry, Graduate School of Pharmaceutical Sciences, University of Tokushima, Shomachi 1, Tokushima 770 8505, Japan
    Neurochem Int 48:243-54. 2006
  8. ncbi request reprint [Molecular mechanism of the regulation of neuronal function based on Ca2+/calmodulin-dependent protein kinase II]
    Takashi Yamauchi
    Institute of Health Biosciences, Graduate School of Pharmaceutical Sciences, The University of Tokushima, Shomachi 1, Tokushima 770 8505, Japan
    Seikagaku 78:840-52. 2006
  9. doi request reprint Domain structure responsible for the different properties between alpha and beta Ca2+/calmodulin-dependent protein kinase II analyzed by their chimera enzymes
    Akiko Deguchi
    Department of Biochemistry, Institute of Health Biosciences and Graduate School of Pharmaceutical Sciences, University of Tokushima, Tokushima, Japan
    Brain Res 1238:1-11. 2008
  10. ncbi request reprint [Molecular mechanism of learning and memory based on the research for Ca2+/calmodulin-dependent protein kinase II]
    Takashi Yamauchi
    Institute of Health Biosciences, Graduate School of Pharmaceutical Sciences, The University of Tokushima, Japan
    Yakugaku Zasshi 127:1173-97. 2007

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Molecular constituents and phosphorylation-dependent regulation of the post-synaptic density
    Takashi Yamauchi
    Department of Biochemistry, Faculty of Pharmaceutical Sciences, The University of Tokushima, Shomachi 1, Tokushima 770 8505, Japan
    Mass Spectrom Rev 21:266-86. 2002
    ..The present review focuses on the molecular properties of PSD proteins, and substrates of protein kinases and their regulation by phosphorylation in order to understand the role of PSD in synaptic plasticity...
  2. ncbi request reprint Neuronal Ca2+/calmodulin-dependent protein kinase II--discovery, progress in a quarter of a century, and perspective: implication for learning and memory
    Takashi Yamauchi
    Department of Biochemistry, Graduate School of Pharmaceutical Sciences, University of Tokushima, Shomachi 1, Tokushima 770 8585, Japan
    Biol Pharm Bull 28:1342-54. 2005
    ..This review presents the molecular structure, properties and functions of CaM kinase II, as a major component of neurons, based mainly developed on findings made in our laboratory...
  3. ncbi request reprint Development and specific induction of apoptosis of cultured cell models overexpressing human tau during neural differentiation: Implication in Alzheimer's disease
    Mariko Tsukane
    Department of Biochemistry, Institute of Health Biosciences and Graduate School of Pharmaceutical Sciences, University of Tokushima, Shomachi 1, Tokushima 770 8505, Japan
    Anal Biochem 360:114-22. 2007
    ..These cells are useful for monitoring the apoptosis by abundant tau and may be applied to investigate the molecular mechanism of apoptosis resembling AD...
  4. ncbi request reprint Molecular constituents of the postsynaptic density fraction revealed by proteomic analysis using multidimensional liquid chromatography-tandem mass spectrometry
    Yoshiyuki Yoshimura
    Department of Biochemistry, Faculty of Pharmaceutical Sciences, The University of Tokushima, Shomachi 1, Tokushima, Japan
    J Neurochem 88:759-68. 2004
    ..These results provide basic data on a major protein set associated with the PSD and a basis for future functional studies of this important neural machinery...
  5. ncbi request reprint Ca2+/calmodulin-dependent protein kinase II mediates apoptosis of P19 cells expressing human tau during neural differentiation with retinoic acid treatment
    Mariko Tsukane
    Department of Biochemistry, Institute of Health Biosciences and Graduate School of Pharmaceutical Sciences, University of Tokushima, Tokushima, Japan
    J Enzyme Inhib Med Chem 24:365-71. 2009
    ..These results indicated that CaM kinase II was involved in the apoptosis of tau/P19 cells induced by RA treatment...
  6. ncbi request reprint Rat leucine-rich protein binds and activates the promoter of the beta isoform of Ca2+/calmodulin-dependent protein kinase II gene
    Nagahiro Ochiai
    Department of Biochemistry, Institute of Health Biosciences and Graduate School of Pharmaceutical Sciences, The University of Tokushima, Shomachi 1, Tokushima 770 8505, Japan
    Neurosci Res 58:67-76. 2007
    ..These results indicate that rLRP157 is one of the proteins binding to, and regulating the activity of, the promoter of beta CaM kinase II...
  7. ncbi request reprint Increase in apoptosis with neural differentiation and shortening of the lifespan of P19 cells overexpressing tau
    Mariko Tsukane
    Department of Biochemistry, Graduate School of Pharmaceutical Sciences, University of Tokushima, Shomachi 1, Tokushima 770 8505, Japan
    Neurochem Int 48:243-54. 2006
    ..These observations suggested that tau affects RA signaling in apoptosis and lifespan during the neural differentiation induced by RA treatment...
  8. ncbi request reprint [Molecular mechanism of the regulation of neuronal function based on Ca2+/calmodulin-dependent protein kinase II]
    Takashi Yamauchi
    Institute of Health Biosciences, Graduate School of Pharmaceutical Sciences, The University of Tokushima, Shomachi 1, Tokushima 770 8505, Japan
    Seikagaku 78:840-52. 2006
  9. doi request reprint Domain structure responsible for the different properties between alpha and beta Ca2+/calmodulin-dependent protein kinase II analyzed by their chimera enzymes
    Akiko Deguchi
    Department of Biochemistry, Institute of Health Biosciences and Graduate School of Pharmaceutical Sciences, University of Tokushima, Tokushima, Japan
    Brain Res 1238:1-11. 2008
    ..These results indicated that the structure of exons 10 and 11 and exons 1 and 2 modified the properties of CaM kinase II holoenzyme...
  10. ncbi request reprint [Molecular mechanism of learning and memory based on the research for Ca2+/calmodulin-dependent protein kinase II]
    Takashi Yamauchi
    Institute of Health Biosciences, Graduate School of Pharmaceutical Sciences, The University of Tokushima, Japan
    Yakugaku Zasshi 127:1173-97. 2007
    ..This review presents molecular structure, properties and functions of CaM kinase II, as a major component of neuron, which are mainly developed in our laboratory...
  11. pmc Proteomic alteration in gastic adenocarcinomas from Japanese patients
    Takahiro Yoshihara
    Department of Medicinal Biotechnology, Institute for Medicinal Resources, Graduate School of Pharmaceutical Sciences, The University of Tokushima, 1 78 Sho machi, Tokushima 770 8505, Japan
    Mol Cancer 5:75. 2006
    ....
  12. ncbi request reprint Overexpression of tau leads to the stimulation of neurite outgrowth, the activation of caspase 3 activity, and accumulation and phosphorylation of tau in neuroblastoma cells on cAMP treatment
    Chihiro Yoshizaki
    Department of Biochemistry, Graduate School of Pharmaceutical Sciences, The University of Tokushima, Shomachi 1, Tokushima 770 8505, Japan
    Neurosci Res 49:363-71. 2004
    ..These observations have implications for the cellular causes of Alzheimer's disease where the accumulation and mislocation of tau occur concomitant with neuronal degeneration...
  13. ncbi request reprint VDAC1, having a shorter N-terminus than VDAC2 but showing the same migration in an SDS-polyacrylamide gel, is the predominant form expressed in mitochondria of various tissues
    Takenori Yamamoto
    Institute for Genome Research, University of Tokushima, Kuramotocho 3, Tokushima 770 8503, Japan
    J Proteome Res 5:3336-44. 2006
    ..As a result, the signal intensity of the spot representing VDAC1 was the highest, and thus, VDAC1 was concluded to be the most abundantly expressed of the three VDAC isoforms in mammalian mitochondria...
  14. ncbi request reprint Identification of protein substrates of Ca(2+)/calmodulin-dependent protein kinase II in the postsynaptic density by protein sequencing and mass spectrometry
    Yoshiyuki Yoshimura
    Department of Biochemistry, Faculty of Pharmaceutical Sciences, The University of Tokushima, Shomachi 1, Tokushima, 770 8505, Japan
    Biochem Biophys Res Commun 290:948-54. 2002
    ..We found 6 proteins not previously known to be substrates of CaM kinase II, namely PSD95-associated protein, SAP97, TOAD-64, TNF receptor-associated protein, insulin-receptor tyrosine kinase 58/53 kDa substrate, and homer 1b...
  15. ncbi request reprint Phosphorylation of tau protein to sites found in Alzheimer's disease brain is catalyzed by Ca2+/calmodulin-dependent protein kinase II as demonstrated tandem mass spectrometry
    Yoshiyuki Yoshimura
    Department of Biochemistry, Faculty of Pharmaceutical Sciences, The University of Tokushima, Shomachi 1, Tokushima 770 8505, Japan
    Neurosci Lett 353:185-8. 2003
    ..Non-fetal-type phosphorylation may produce PHF-tau. These results suggested that CaMKII is involved in the phosphorylation of tau in Alzheimer's disease brain...
  16. ncbi request reprint Interaction of Arc with CaM kinase II and stimulation of neurite extension by Arc in neuroblastoma cells expressing CaM kinase II
    Hitomi Donai
    Department of Biochemistry, Faculty of Pharmaceutical Sciences, The University of Tokushima, Shomachi 1, Tokushima 770 8505, Japan
    Neurosci Res 47:399-408. 2003
    ..The growth of neurites by Arc was completely blocked by treatment with KN62, an inhibitor of CaM kinases. These results indicated that Arc potentiated the action of CaM kinase II for neurite extension...
  17. ncbi request reprint Neuronal cell type-specific promoter of the alpha CaM kinase II gene is activated by Zic2, a Zic family zinc finger protein
    Takumi Sakurada
    Department of Biochemistry, Graduate School of Pharmaceutical Sciences, The University of Tokushima, Shomachi 1, Tokushima 770 8505, Japan
    Neurosci Res 53:323-30. 2005
    ..These results indicated that Zic2 was one of the proteins binding to, and regulating the activity of, the promoter of alpha CaM kinase II...
  18. ncbi request reprint Regulation of exocytosis through Ca2+/ATP-dependent binding of autophosphorylated Ca2+/calmodulin-activated protein kinase II to syntaxin 1A
    Akihiro Ohyama
    Department of Molecular and Cellular Neurobiology, Gunma University School of Medicine, Maebashi, Gunma 371 8511, Japan
    J Neurosci 22:3342-51. 2002
    ..These results indicate that the Ca2+/ATP-dependent binding of CaMKII to syntaxin is an important process in the regulation of exocytosis...
  19. ncbi request reprint Interaction of LDL receptor-related protein 4 (LRP4) with postsynaptic scaffold proteins via its C-terminal PDZ domain-binding motif, and its regulation by Ca/calmodulin-dependent protein kinase II
    Qing Bao Tian
    Department of Neuroplasticity, Institute on Ageing and Adaptation, Shinshu University Graduate School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Eur J Neurosci 23:2864-76. 2006
    ..These findings suggest a postsynaptic role for LRP4, a putative endocytic multiligand receptor, and a mechanism in which CaMKII regulates PDZ-dependent protein-protein interactions and receptor dynamics...
  20. doi request reprint Ubiquitin-mediated stress response in the spinal cord after transient ischemia
    Takashi Yamauchi
    Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka, 565 0871, Japan
    Stroke 39:1883-9. 2008
    ..In the present study, we investigated the expression of ubiquitin system molecules and discussed the relationship between the vulnerability and the ubiquitin system after transient ischemia in the spinal cord...
  21. ncbi request reprint Impact of the endoplasmic reticulum stress response in spinal cord after transient ischemia
    Takashi Yamauchi
    Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka, 565 0871, Japan
    Brain Res 1169:24-33. 2007
    ..In the present study, we investigate the expression of ER stress-related molecules and discuss the relationship between neuronal vulnerability and ER stress after transient ischemia in the spinal cord...
  22. ncbi request reprint Expression of reelin in the dorsal cochlear nucleus of the mouse
    Yuka Takaoka
    Division of Anatomy and Neurobiology, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Brain Res Dev Brain Res 159:127-34. 2005
    ..The present findings imply that Reelin may have some roles in the formation of laminar structures of the DCN...
  23. ncbi request reprint ONO-5046 attenuation of delayed motor neuron death and effect on the induction of brain-derived neurotrophic factor, phosphorylated extracellular signal-regulated kinase, and caspase3 after spinal cord ischemia in rabbits
    Takashi Yamauchi
    Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Osaka, Japan
    J Thorac Cardiovasc Surg 131:644-50. 2006
    ..The aim of this study was to investigate whether ONO-5046, a specific inhibitor of neutrophil elastase that can attenuate tissue or organ injury in various pathologic conditions, could protect against ischemic spinal cord damage...
  24. ncbi request reprint Identification of Tau and MAP2 as novel substrates of Rho-kinase and myosin phosphatase
    Mutsuki Amano
    Department of Cell Pharmacology, Graduate School of Medicine, Nagoya University, Aichi, Japan
    J Neurochem 87:780-90. 2003
    ..Thus, it is likely that the Rho-kinase/MBS pathway regulates not only the actin-myosin system but also microtubule dynamics...
  25. ncbi request reprint Neuroprotective effects of activated protein C through induction of insulin-like growth factor-1 (IGF-1), IGF-1 receptor, and its downstream signal phosphorylated serine-threonine kinase after spinal cord ischemia in rabbits
    Takashi Yamauchi
    Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Osaka, Japan
    Stroke 37:1081-6. 2006
    ..However, the possible mechanism of such beneficial effects is not fully understood. The aim of this study was to investigate the effects and possible mechanisms of APC on ischemic spinal cord damage...
  26. ncbi request reprint Inhibitory role of endophilin 3 in receptor-mediated endocytosis
    Hiroko Sugiura
    Department of Neuropharmacology, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Tokyo 183 8526, Japan
    J Biol Chem 279:23343-8. 2004
    ..These results indicate that Endo3 may act as a negative regulator of clathrin-mediated endocytosis in brain neurons...