Junzo Watanabe

Summary

Affiliation: The University of Tokyo
Country: Japan

Publications

  1. doi request reprint Lipid effects of psychiatric medications
    Junzo Watanabe
    Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, 757 Asahimachidori ichibancho, Chuo Ku, Niigata, 951 8510, Japan
    Curr Atheroscler Rep 15:292. 2013
  2. ncbi request reprint Effect of the cytochrome P450 2D6*10 allele on risperidone metabolism in Japanese psychiatric patients
    Yutaro Suzuki
    Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Hum Psychopharmacol 27:43-6. 2012
  3. doi request reprint Dose-dependent effects of olanzapine on QT intervals and plasma prolactin levels in Japanese patients with stable schizophrenia
    Yutaro Suzuki
    Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Hum Psychopharmacol 26:440-3. 2011
  4. doi request reprint CYP2D6 genotype and smoking influence fluvoxamine steady-state concentration in Japanese psychiatric patients: lessons for genotype-phenotype association study design in translational pharmacogenetics
    Yutaro Suzuki
    Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Psychopharmacol 25:908-14. 2011
  5. doi request reprint QT prolongation of the antipsychotic risperidone is predominantly related to its 9-hydroxy metabolite paliperidone
    Yutaro Suzuki
    Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Hum Psychopharmacol 27:39-42. 2012
  6. doi request reprint Differences in plasma prolactin levels in patients with schizophrenia treated on monotherapy with five second-generation antipsychotics
    Yutaro Suzuki
    Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Chuo Ku, Niigata 951 8510, Japan
    Schizophr Res 145:116-9. 2013
  7. doi request reprint Excessive insulin secretion in Japanese schizophrenic patients treated with antipsychotics despite normal fasting glucose levels
    Takuro Sugai
    Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Clin Psychopharmacol 32:750-5. 2012
  8. doi request reprint The wide variability of perospirone metabolism and the effect of perospirone on prolactin in psychiatric patients
    Yutaro Suzuki
    Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 34:830-3. 2010
  9. doi request reprint Dysregulation of adipocytokines related to second-generation antipsychotics in normal fasting glucose patients with schizophrenia
    Takuro Sugai
    Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Clin Psychopharmacol 32:390-3. 2012
  10. doi request reprint Increased risk of antipsychotic-related QT prolongation during nighttime: a 24-hour holter electrocardiogram recording study
    Junzo Watanabe
    Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Clin Psychopharmacol 32:18-22. 2012

Collaborators

Detail Information

Publications23

  1. doi request reprint Lipid effects of psychiatric medications
    Junzo Watanabe
    Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, 757 Asahimachidori ichibancho, Chuo Ku, Niigata, 951 8510, Japan
    Curr Atheroscler Rep 15:292. 2013
    ..Further investigations are needed to evaluate the effects of antidepressive agents on lipid profiles...
  2. ncbi request reprint Effect of the cytochrome P450 2D6*10 allele on risperidone metabolism in Japanese psychiatric patients
    Yutaro Suzuki
    Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Hum Psychopharmacol 27:43-6. 2012
    ..We investigated the effect of the number of CYP2D6*10 alleles on steady-state plasma RIS, 9-OH-RIS, and active moiety levels in Japanese patients...
  3. doi request reprint Dose-dependent effects of olanzapine on QT intervals and plasma prolactin levels in Japanese patients with stable schizophrenia
    Yutaro Suzuki
    Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Hum Psychopharmacol 26:440-3. 2011
    ..This study evaluated the dose-dependent effect of OLZ on QT interval and plasma prolactin (PRL) level in a single sample of patients with schizophrenia...
  4. doi request reprint CYP2D6 genotype and smoking influence fluvoxamine steady-state concentration in Japanese psychiatric patients: lessons for genotype-phenotype association study design in translational pharmacogenetics
    Yutaro Suzuki
    Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Psychopharmacol 25:908-14. 2011
    ..Additionally, these data lend evidence for drug dose as an important variable in translational pharmacogenetic study design and pharmaceutical phenotype associations with capacity-limited drug metabolism pathways such as CYP2D6...
  5. doi request reprint QT prolongation of the antipsychotic risperidone is predominantly related to its 9-hydroxy metabolite paliperidone
    Yutaro Suzuki
    Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Hum Psychopharmacol 27:39-42. 2012
    ..However, few reports have so far addressed QT prolongation associated with the use of risperidone or its major active metabolite, which is also used as a separate antipsychotic drug, paliperidone...
  6. doi request reprint Differences in plasma prolactin levels in patients with schizophrenia treated on monotherapy with five second-generation antipsychotics
    Yutaro Suzuki
    Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Chuo Ku, Niigata 951 8510, Japan
    Schizophr Res 145:116-9. 2013
    ..In this study, OLZ had a considerable effect on plasma PRL level, similar to RIS, while PER did not affect plasma PRL levels, similar to QTP. Further studies are needed to clarify the differences in plasma PRL levels among SGAs...
  7. doi request reprint Excessive insulin secretion in Japanese schizophrenic patients treated with antipsychotics despite normal fasting glucose levels
    Takuro Sugai
    Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Clin Psychopharmacol 32:750-5. 2012
    ..These results suggest that APs affect the glucose-insulin response, which may lead to subclinical insulin resistance before the onset of overt glucose intolerance...
  8. doi request reprint The wide variability of perospirone metabolism and the effect of perospirone on prolactin in psychiatric patients
    Yutaro Suzuki
    Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 34:830-3. 2010
    ....
  9. doi request reprint Dysregulation of adipocytokines related to second-generation antipsychotics in normal fasting glucose patients with schizophrenia
    Takuro Sugai
    Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Clin Psychopharmacol 32:390-3. 2012
    ..Recent studies have suggested a possible impact of SGAs on endocrine regulation, especially on adipocytokines. We examined the effect of each SGA on various adipocytokines in normal fasting glucose (NFG) subjects...
  10. doi request reprint Increased risk of antipsychotic-related QT prolongation during nighttime: a 24-hour holter electrocardiogram recording study
    Junzo Watanabe
    Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Clin Psychopharmacol 32:18-22. 2012
    ..In clinical practices, evaluations of the QT interval have been conducted over short periods in the daytime, but it is believed that such methods may not be able to fully elucidate the effects of antipsychotics on the QT interval...
  11. ncbi request reprint [Customized pharmacotherapies in schizophrenia]
    Yutaro Suzuki
    Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, 757, Asahimachidori Ichibancho, Niigata, 951 8510 Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 30:77-81. 2010
    ....
  12. doi request reprint The lipid profiles in Japanese patients with schizophrenia treated with antipsychotic agents
    Junzo Watanabe
    Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Chuo Ku, Niigata 951 8510, Japan
    Gen Hosp Psychiatry 34:525-8. 2012
    ..The aim of this study was to investigate the effect of schizophrenia patients receiving antipsychotic agents on each lipid measure in a Japanese population...
  13. doi request reprint Dose-dependent effect of the CYP2D6 genotype on the steady-state fluvoxamine concentration
    Junzo Watanabe
    Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Ther Drug Monit 30:705-8. 2008
    ..The present study suggests that the effect of the CYP2D6 genotype on fluvoxamine metabolism is greater at lower doses of fluvoxamine...
  14. doi request reprint Differences in clinical effect and tolerance between fluvoxamine and paroxetine: a switching study in patients with depression
    Yutaro Suzuki
    Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Chuo Ku, Niigata, Japan
    Hum Psychopharmacol 25:525-9. 2010
    ..We examined whether discontinuation and the responses to fluvoxamine (FLV) administration could predict the subsequent discontinuation and the responses to paroxetine (PRX) in patients with depression...
  15. doi request reprint Gender differences in the relationship between the risperidone metabolism and the plasma prolactin levels in psychiatric patients
    Yutaro Suzuki
    Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 34:1266-8. 2010
    ..The present study evaluated the gender differences in the relationship between plasma levels of RIS or 9-OH-RIS and PRL...
  16. doi request reprint The prevalence of glucose intolerance in Japanese schizophrenic patients with a normal fasting glucose level
    Shin Ono
    Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Clin Psychopharmacol 33:525-7. 2013
    ..We investigated the prevalence of abnormal glucose tolerance after glucose loading among Japanese inpatients with schizophrenia, with normal fasting glucose levels...
  17. doi request reprint Sex differences in the effect of four second-generation antipsychotics on QTc interval in patients with schizophrenia
    Yutaro Suzuki
    Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Chuo Ku, Niigata, Japan
    Hum Psychopharmacol 28:215-9. 2013
    ..We examined sex differences in the effect of olanzapine (OLZ), risperidone (RIS), aripiprazole (ARP), or quetiapine (QTP) on mean corrected QT (QTc) intervals among 222 patients with schizophrenia...
  18. doi request reprint Low prevalence of metabolic syndrome and its prediction in Japanese inpatients with schizophrenia
    Yutaro Suzuki
    Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Hum Psychopharmacol 28:188-91. 2013
    ..We studied the MetS prevalence rate in Japanese controls and inpatients with schizophrenia and compared the prediction factors for the occurrence of MetS...
  19. doi request reprint Impact of the ABCB1 Gene Polymorphism on Plasma 9-Hydroxyrisperidone and Active Moiety Levels in Japanese Patients With Schizophrenia
    Yutaro Suzuki
    From the Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Clin Psychopharmacol 33:411-4. 2013
    ..On the other hand, the ABCB1 2677G>T/A genotypes did not affect plasma RIS, 9-OH-RIS, or total active moiety levels. The ABCB1 3435C>T genetic polymorphism may predict plasma 9-OH-RIS and total active moiety levels...
  20. doi request reprint Changes in QT interval after switching to quetiapine in Japanese patients with schizophrenia
    Yutaro Suzuki
    Department of Psychiatry, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
    Hum Psychopharmacol 28:94-6. 2013
    ..There are few reports regarding quetiapine (QTP)-related QT prolongation. We examined the change in QT interval after switching from aripiprazole (ARP), olanzapine (OLZ), or risperidone (RIS) to QTP...
  21. doi request reprint Concentration-response relationship for fluvoxamine using remission as an endpoint: a receiver operating characteristics curve analysis in major depression
    Yutaro Suzuki
    Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, 757 Asahimachidori ichibancho, Niigata, Japan
    J Clin Psychopharmacol 28:325-8. 2008
    ....
  22. doi request reprint Diagnostic classification of schizophrenia by neural network analysis of blood-based gene expression signatures
    Makoto Takahashi
    Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi dori 1 757, Niigata 951 8510, Japan
    Schizophr Res 119:210-8. 2010
    ..These results suggest analysis of a blood-based gene expression signature with the supervised classifier, ANNs, might be a diagnostic tool for schizophrenia...
  23. ncbi request reprint Dose-dependent effects of the 3435 C>T genotype of ABCB1 gene on the steady-state plasma concentration of fluvoxamine in psychiatric patients
    Naoki Fukui
    Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Ther Drug Monit 29:185-9. 2007
    ..This study investigated effects of the 3435 C>T genotype of the adenosine triphosphate-binding cassette subfamily B member 1 (ABCB1, MDR1) gene on the steady-state plasma concentration of fluvoxamine (FLV)...