Research Topics
Genomes and GenesSpecies | M TakedaSummaryAffiliation: The Nippon Dental University Country: Japan Publications
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Publications
Changes in c-Fos expression induced by noxious stimulation in the trigeminal spinal nucleus caudalis and C1 spinal neurons of rats after hyperbaric exposureM Takeda
Department of Physiology, School of Dentistry at Tokyo, Nippon Dental University, Japan
Arch Histol Cytol 62:165-70. 1999..These results suggest that hyperbaric exposure may attenuate nociceptive signals from the area innervated by the trigeminal nerves at the level of both the trigeminal spinal nucleus caudalis and C1 dorsal horn...- The functional difference between transient and sustained K+ currents on the action potentials in tetrodotoxin-resistant adult rat trigeminal ganglion neuronsShinki Yoshida
Department of Physiology, Nippon Dental University, School of Life Dentistry at Tokyo, Tokyo, Japan
Brain Res 1152:64-74. 2007..These results suggested that I(A) and I(K) had independent effects regulating the intrinsic firing properties of the action potential number and timing, respectively, in adult rat TTX-R TG neurons... 
Contribution of activated interleukin receptors in trigeminal ganglion neurons to hyperalgesia via satellite glial interleukin-1beta paracrine mechanismMamoru Takeda
Department of Physiology, School of Life Dentistry at Tokyo, Nippon Dental University, 1 9 20, Fujimi cho, Chiyoda ku, Tokyo 102 8159, Japan
Brain Behav Immun 22:1016-23. 2008..Such an IL-1beta release could be important in determining trigeminal inflammatory hyperalgesia...- Glial cell line-derived neurotrophic factor modulates the excitability of nociceptive trigeminal ganglion neurons via a paracrine mechanism following inflammationMamoru Takeda
Department of Physiology, School of Life Dentistry at Tokyo, Nippon Dental University, 1 9 20, Fujimi cho, Chiyoda ku, Tokyo 102 8159, Japan
Brain Behav Immun 28:100-7. 2013..GDNF paracrine mechanism could be important as a therapeutic target for trigeminal inflammatory hyperalgesia... - Suppression of neurokinin-1 receptor in trigeminal ganglia attenuates central sensitization following inflammationMamoru Takeda
Department of Physiology, School of Life Dentistry at Tokyo, Nippon Dental University, Tokyo, Japan
J Peripher Nerv Syst 17:169-81. 2012..These results suggest that in the early stages of inflammation suppression of the NK1 receptor mechanism in TRGs may prevent central sensitization of SpVc nociceptive neurons... 
Alteration of primary afferent activity following inferior alveolar nerve transection in ratsKazuharu Nakagawa
Department of Dysphagia Rehabilitation, Nihon University School of Dentistry, 1 8 13 Kanda Surugadai, Chiyoda ku, Tokyo, 101 8310, Japan
Mol Pain 6:9. 2010..In order to evaluate the neural mechanisms underlying the abnormal facial pain that may develop following regeneration of the injured inferior alveolar nerve (IAN), the properties of the IAN innervated in the mental region were analyzed...- Effects of GABA(A) and glycine receptor agonists on the medullary inspiratory neuronal activity during spontaneous augmented breaths in anesthetized ratsMamoru Takeda
Department of Physiology, Nippon Dental University, School of Dentistry at Tokyo, 1 9 20, Fujimi cho, Chiyoda ku, Japan
Life Sci 71:2681-90. 2002..These results suggested that the excitatory inputs to inspiratory neurons during the phase II of augmented breaths may not be significantly influenced by the activation of either GABA(A) receptors or glycine receptors... - Effects of gadolinium and tetrodotoxin on the response of slowly adapting type I mechanoreceptors to mechanical stimulation in frog dorsal skinMamoru Takeda
Department of Physiology, School of Dentistry at Tokyo, Nippon Dental University, Tokyo, Japan
J Peripher Nerv Syst 8:271-81. 2003.... - Activaton of GABAB receptor inhibits the excitability of rat small diameter trigeminal root ganglion neuronsM Takeda
Department of Physiology, School of Dentistry at Tokyo, Nippon Dental University, 1 9 20, Fujimi cho, Chiyoda ku, Tokyo, 102 8159, Japan
Neuroscience 123:491-505. 2004.... - Opioidergic modulation of excitability of rat trigeminal root ganglion neuron projections to the superficial layer of cervical dorsal hornM Takeda
Department of Physiology, School of Dentistry at Tokyo, Nippon Dental University, 1 9 20, Fujimi cho, Chiyoda ku, Tokyo, 102 8159 Japan
Neuroscience 125:995-1008. 2004.... - Activation of interleukin-1beta receptor suppresses the voltage-gated potassium currents in the small-diameter trigeminal ganglion neurons following peripheral inflammationMamoru Takeda
Department of Physiology, Nippon Dental University, Fujimi cho, Chiyoda ku, Tokyo, Japan
Pain 139:594-602. 2008..These findings provide evidence for the development of voltage-gated K(+) channel openers and IL-1beta antagonists as therapeutic agents for the treatment of trigeminal inflammatory hyperalgesia... - Activation of NK1 receptor of trigeminal root ganglion via substance P paracrine mechanism contributes to the mechanical allodynia in the temporomandibular joint inflammation in ratsMamoru Takeda
Department of Physiology, School of Dentistry at Tokyo, Nippon Dental University, Tokyo, 102 8159, Japan
Pain 116:375-85. 2005..Such a SP release may play an important role in determining the trigeminal inflammatory allodynia concerning the temporomandibular disorder... - Role of capsaicin-sensitive primary afferent inputs from the masseter muscle in the C1 spinal neurons responding to tooth-pulp stimulation in ratsM Takeda
Department of Physiology, School of Dentistry at Tokyo, Nippon Dental University, 1 9 20, Fujimi cho, Chiyoda ku, 102 8159 Tokyo, Japan
Exp Brain Res 160:107-17. 2005.... - Temporomandibular joint inflammation potentiates the excitability of trigeminal root ganglion neurons innervating the facial skin in ratsMamoru Takeda
Department of Physiology, School of Dentistry at Tokyo, Nippon Dental University, 1 9 20, Fujimi cho, Chiyoda ku, Tokyo 102 8159, Japan
J Neurophysiol 93:2723-38. 2005.... - Somatostatin inhibits the excitability of rat small-diameter trigeminal ganglion neurons that innervate nasal mucosa and project to the upper cervical dorsal horn via activation of somatostatin 2a receptorM Takeda
Department of Physiology, School of Life Dentistry at Tokyo, Nippon Dental University, 1 9 20, Fujimi cho, Chiyoda ku, Tokyo 102 8159, Japan
Neuroscience 148:744-56. 2007.... - Temporomandibular joint inflammation decreases the voltage-gated K+ channel subtype 1.4-immunoreactivity of trigeminal ganglion neurons in ratsMamoru Takeda
Department of Physiology, Nippon Dental University, 1 9 20, Fujimi cho, Chiyoda ku, Tokyo 102 8159, Japan
Eur J Pain 12:189-95. 2008..These results lead us to suggest that Kv channel openers may be a potential therapeutic agents for prevention of mechanical allodynia... - Enhanced excitability of nociceptive trigeminal ganglion neurons by satellite glial cytokine following peripheral inflammationMamoru Takeda
Department of Physiology, School of Life Dentistry at Tokyo, Nippon Dental University, 1 9 20, Fujimi cho, Chiyoda ku, 102 8159 Tokyo, Japan
Pain 129:155-66. 2007..Therefore IL-1beta blockers are potential therapeutic agents for prevention of trigeminal hyperalgesia... - N-methyl-D-aspartate (NMDA) and non-NMDA receptor antagonists suppress the superior sagittal sinus-evoked activity of C1 spinal neurons responding to tooth pulp electrical stimulation in ratsYoshinobu Fujimi
Department of Physiology, The Nippon Dental University School of Life Dentistry at Tokyo, 1 9 20 Fujimi, Chiyoda ku, Tokyo, 102 8159, Japan
Odontology 94:22-8. 2006.... - Enhanced excitability of rat trigeminal root ganglion neurons via decrease in A-type potassium currents following temporomandibular joint inflammationM Takeda
Department of Physiology, School of Dentistry at Tokyo, Nippon Dental University, 1 9 20, Fujimi cho, Chiyoda ku, Tokyo 102 8159, Japan
Neuroscience 138:621-30. 2006..These changes may contribute to trigeminal inflammatory allodynia in temporomandibular joint disorder... - Activation of alpha2-adrenoreceptors suppresses the excitability of C1 spinal neurons having convergent inputs from tooth pulp and superior sagittal sinus in ratsM Takeda
Department of Physiology, School of Dentistry at Tokyo, Nippon Dental University, 1 9 20 Fujimi cho, Chiyoda ku, Tokyo, 102 8159, Japan
Exp Brain Res 174:210-20. 2006.... - Changes of the excitability of rat trigeminal root ganglion neurons evoked by alpha(2)-adrenoreceptorsM Takeda
Department of Physiology, School of Dentistry at Tokyo, Nippon Dental University, 1 9 20 Fujimi cho, Chiyoda ku, Tokyo 102 8159, Japan
Neuroscience 115:731-41. 2002.... - Systemic administration of lidocaine suppresses the excitability of rat cervical dorsal horn neurons and tooth-pulp-evoked jaw-opening reflexMamoru Takeda
Department of Physiology, School of Life Dentistry at Tokyo, Nippon Dental University, Tokyo, Japan
Eur J Pain 13:929-34. 2009..Systemic lidocaine administration, therefore, may contribute to the alleviation of trigeminal-referred pain associated with tooth pain... - Change in mechanical receptive field properties induced by GABA(A) receptor activation in the trigeminal spinal nucleus caudalis neurons in ratsM Takeda
Department of Physiology, Nippon Dental University, School of Dentistry at Tokyo, Japan
Exp Brain Res 134:409-16. 2000.... - In vivo patch-clamp analysis of response properties of rat primary somatosensory cortical neurons responding to noxious stimulation of the facial skinMamoru Takeda
Department of Physiology, School of Life Dentistry at Tokyo, Nippon Dental University, 1 9 20, Fujimi cho, Chiyoda ku, Tokyo, 102 8159, Japan
Mol Pain 6:30. 2010..The aim of the present study was to examine whether noxious stimulation applied to the orofacial area evokes the synaptic response of SI neurons in urethane-anesthetized rats using an in vivo patch-clamp technique... - Glial cell line-derived neurotrophic factor acutely modulates the excitability of rat small-diameter trigeminal ganglion neurons innervating facial skinMamoru Takeda
Department of Physiology, School of Life Dentistry at Tokyo, Nippon Dental University, 1 9 20, Fujimi cho, Chiyoda ku, Tokyo 102 8159, Japan
Brain Behav Immun 24:72-82. 2010..We therefore conclude that a local release of GDNF from TRG neuronal soma and/or nerve terminals may regulate normal sensory function, including nociception... - Contribution of the activation of satellite glia in sensory ganglia to pathological painMamoru Takeda
Department of Physiology, School of Life Dentistry at Tokyo, Nippon Dental University, Chiyoda ku, Tokyo, Japan
Neurosci Biobehav Rev 33:784-92. 2009..In addition, we discuss potential therapeutic targets in satellite glia-neuronal interactions for the prevention of pathological pain... - Volume expansion suppresses the tooth-pulp evoked jaw-opening reflex related activity of trigeminal neurons in ratsMamoru Takeda
Department of Physiology, School of Dentistry at Tokyo, Nippon Dental University, Tokyo, Japan
Brain Res Bull 58:83-9. 2002..These results therefore suggest that low-pressure cardiopulmonary baroreceptors whose afferents travel in the vagus nerve inhibit the pulpal nociceptive transmission... - Potassium channels as a potential therapeutic target for trigeminal neuropathic and inflammatory painMamoru Takeda
Department of Physiology, School of Life Dentistry at Tokyo, Nippon Dental University, 1 9 20 Fujimi cho, Chiyoda ku, Tokyo, Japan
Mol Pain 7:5. 2011..We also discuss the potential of Kv channel openers as therapeutic agents for trigeminal neuropathic/inflammatory pain, such as mechanical allodynia... - Peripheral inflammation suppresses inward rectifying potassium currents of satellite glial cells in the trigeminal gangliaMamoru Takeda
Department of Physiology, School of Life Dentistry at Tokyo, Nippon Dental University, 1 9 20, Fujimi cho, Chiyoda ku, Tokyo 102 8159, Japan
Pain 152:2147-56. 2011..Therefore, the Kir4.1 channel in SGCs may be a new molecular target for the treatment of trigeminal inflammatory pain... - Somatostatin inhibits tooth-pulp-evoked rat cervical dorsal horn neuronal activityM Takahashi
Department of Physiology, School of Life Dentistry at Tokyo, Nippon Dental University, 1 9 20 Fujimi, Tokyo, 102 8159 Japan
Exp Brain Res 184:617-22. 2008..These results suggest that a local release of SST modulates the TP-evoked C(1) neuronal activity and this may contribute to a useful therapeutic target for the alleviation of tooth pain and trigeminal hyperalgesia... - Excitability of small-diameter trigeminal ganglion neurons by 5-HT is mediated by enhancement of the tetrodotoxin-resistant sodium current due to the activation of 5-HT(4) receptors and/or by the inhibition of the transient potassium currentY Tsutsui
Department of Physiology, Nippon Dental University, School of Life Dentistry at Tokyo, 1 9 20 Fujimi, Chiyoda ku, Tokyo 102 8159, Japan
Neuroscience 157:683-96. 2008.... - Suppressive effect of vagal afferents on cervical dorsal horn neurons responding to tooth pulp electrical stimulation in the ratT Tanimoto
Department of Physiology, Nippon Dental University, School of Dentistry at Tokyo, 1 9 20 Fujimi, Chiyoda ku, Tokyo 102 8159, Japan
Exp Brain Res 145:468-79. 2002..These results suggest that VA stimulation inhibits nociceptive transmission in the C1 spinal neuron activity via the activation of both noradrenergic and serotonergic (5-HT(3)) descending inhibitory systems... - Prostaglandin E2 potentiates the excitability of small diameter trigeminal root ganglion neurons projecting onto the superficial layer of the cervical dorsal horn in ratsJun Kadoi
Department of Physiology, Nippon Dental University, School of Dentistry at Tokyo, 1 9 20, Fujimi cho, Chiyoda ku, Tokyo, 102 8159, Japan
Exp Brain Res 176:227-36. 2007..These results suggest that the excitability of small diameter TRG neurons seen after 1 microM PGE2 application is involved in an increase in the.. - Effects of potassium channel blockers on hyperinflation-induced rapidly adapting pulmonary stretch receptor stimulation in the rabbitS Matsumoto
Department of Physiology, Nippon Dental University, School of Dentistry at Tokyo, Japan
Life Sci 70:491-501. 2001.... - Effects of acetazolamide and 4-aminoprydine on the responses of deflationary slowly adapting pulmonary stretch receptors to CO2 inhalation in the ratS Matsumoto
Department of Physiology, Nippon Dental University, School of Dentistry at Tokyo, 1 9 20 Fujimi, Chiyoda ku, Tokyo 102 8159, Japan
Life Sci 72:1757-71. 2003..These results suggest that inhibition of deflationary SARs by CO(2) inhalation may be largely mediated by the stimulating action of 4-AP-sensitive K(+) currents in the nerve terminals of the receptors... - Role of organic anion transporter 1 (OAT1) in cephaloridine (CER)-induced nephrotoxicityM Takeda
Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Tokyo, Japan
Kidney Int 56:2128-36. 1999..Role of organic anion transporter 1 (OAT1) in cephaloridine (CER)-induced nephrotoxicity... - Effects of potassium channel and Na+-Ca2+ exchange blockers on the responses of slowly adapting pulmonary stretch receptors to hyperinflation in flecainide-treated ratsS Matsumoto
Department of Physiology, Nippon Dental University, School of Dentistry at Tokyo, 1-9-20 Fujimi, Chiyoda-ku, Tokyo 102-8159, Japan
Br J Pharmacol 134:682-90. 2001..4. These results suggest that hyperinflation-induced SAR inhibition in the presence of flecainide (9 mg kg(-1)) involves the activation of several K(+) conductance pathways... - Prostaglandin E2-induced modification of tetrodotoxin-resistant Na+ currents involves activation of both EP2 and EP4 receptors in neonatal rat nodose ganglion neuronesShigeji Matsumoto
Department of Physiology, Nippon Dental University, School of Dentistry at Tokyo, 1-9-20 Fujimi, Chiyoda-ku, Tokyo 102-8159, Japan
Br J Pharmacol 145:503-13. 2005..7 These results suggest that the PGE2-induced modification of I(NaR) is mainly mediated by activation of both EP2 and EP4 receptors... - Mechanisms involved in modulation of trigeminal primary afferent activity in rats with peripheral mononeuropathyJunichi Kitagawa
Department of Physiology, School of Dentistry, Nihon University, 1-8-13 Kandasurugadai, Chiyoda-ku Tokyo, 101-8310, Japan
Eur J Neurosci 24:1976-86. 2006.... - Effect of sodium benzylideneascorbate on chemically-induced tumors in ratsH Sakagami
First Department of Biochemistry, School of Medicine, Showa University, Tokyo, Japan
Anticancer Res 13:65-71. 1993..These data suggest that the conditions of SBA administration should be re-established for each tumor sample to produce maximum antitumor activity... - Effect of ouabain on the afterhyperpolarization of slowly adapting pulmonary stretch receptors in the rat lungShigeji Matsumoto
Department of Physiology, Nippon Dental University, School of Dentistry at Tokyo, 1 9 20 Fujimi, Chiyoda ku, Tokyo 102 8159, Japan
Brain Res 1107:131-9. 2006..These results suggest that the mechanism of generating the AHP of SARs is mainly mediated by the activation of Na+-K+ ATPase alpha3 subunit isoform... - The effects of ouabain on resting membrane potential and hyperpolarization-activated current in neonatal rat nodose ganglion neuronsShigeji Matsumoto
Department of Physiology, Nippon Dental University, School of Life Dentistry at Tokyo, 1 9 20 Fujimi, Chiyoda ku, Tokyo 102 8159, Japan
Neurosci Lett 439:241-4. 2008..These results suggest that ouabain application at 1microM is capable of setting both the RMP level and the neuronal excitability in small-diameter NG neurons... - Effects of acetazolamide and 4-aminopyridine on CO2-induced slowly adapting pulmonary stretch receptor inhibition in ratsShigeji Matsumoto
Department of Physiology, Nippon Dental University, School of Dentistry at Tokyo, 1 9 20 Fujimi, Chiyoda ku, Tokyo 102 8159, Japan
Chem Senses 29:351-61. 2004..These results suggest that CO(2)-induced inhibition of SARs may be involved in the CA-dependent CO(2) hydration in addition to the activation of 4-AP sensitive K(+) currents... - Excitatory mechanism of deflationary slowly adapting pulmonary stretch receptors in the rat lungShigeji Matsumoto
Department of Physiology, Nippon Dental University, School of Dentistry at Tokyo, Tokyo, Japan
J Pharmacol Exp Ther 300:597-604. 2002..0 and 6.0 mg/kg). These results suggest that the excitatory effect of lung deflation on deflationary SAR activity is mediated by the activation of flecainide-sensitive Na(+) channels on the nerve terminals of deflationary SARs... - The roles of I(D), I(A) and I(K) in the electrophysiological functions of small diameter rat trigeminal ganglion neuronsShigeji Matsumoto
Department of Physiology, Nippon Dental University, School of Life Dentistry at Tokyo, Tokyo, Japan
Curr Mol Pharmacol 3:30-6. 2010..Thus, reducing effects of both I(A) and I(K) may be useful to investigate the mechanism of allodynia... - Convergence of nociceptive information from temporomandibular joint and tooth pulp afferents on C1 spinal neurons in the ratToshimi Nishikawa
Department of Physiology, Nippon Dental University, School of Dentistry at Tokyo, 1 9 20 Fujimi, Chiyoda ku, Tokyo 102 8159, Japan
Life Sci 75:1465-78. 2004..These results suggest that there is a convergence of noxious information from the TMJ and TP afferents on the same C1 spinal neurons, which importantly contribute to pain perception from the TMJ region... - Flecainide inhibits the stimulatory effect of veratridine on the response of airway mechanoreceptors to maintained inflations in ratsShigeji Matsumoto
Department of Physiology, Nippon Dental University, School of Life Dentistry at Tokyo, 1 9 20 Fujimi, Chiyoda ku, Tokyo 102 8159, Japan
Life Sci 87:411-9. 2010.... - Tooth-pulp-evoked rostral spinal trigeminal nucleus neuron activity is inhibited by conditioning sciatic nerve stimulation in the rat: possible role of 5-HT3 receptor mediated GABAergic inhibitionKatsuo Oshima
General Dentistry of University Hospital, The Nippon Dental University, School of Dentistry at Tokyo, Chiyoda ku, Tokyo 102 8158, Japan
Brain Res Bull 65:31-40. 2005.... - Effect of 8-bromo-cAMP on the tetrodotoxin-resistant sodium (Nav 1.8) current in small-diameter nodose ganglion neuronsShigeji Matsumoto
Department of Physiology, Nippon Dental University, School of Dentistry at Tokyo, 1 9 20 Fujimi, Chiyoda ku, Tokyo 102 8159, Japan
Neuropharmacology 52:904-24. 2007..8 current amplitude and further enhanced the Ro-31-8425-induced decrease in the current. These results suggest that the 8-Br-cAMP-induced increase in Nav 1.8 currents may be mediated by activation of both PKA and PKC... - Immunohistochemical co-expression of carbonic anhydrase II with Kv1.4 and TRPV1 in rat small-diameter trigeminal ganglion neuronsTakeshi Tanimoto
Department of Physiology, Nippon Dental University, School of Dentistry at Tokyo, 1 9 20 Fujimi, Tokyo 102 8159, Japan
Brain Res 1044:262-5. 2005..The fact that CAII-immunoreactive TG neurons revealed a common expression of both Kv1.4 and TRPV1 leads us to suggest that CAII may be one of the nociceptive neuronal markers... - The role of 5-hydroxytryptamine3 receptors in the vagal afferent activation-induced inhibition of the first cervical dorsal horn spinal neurons projected from tooth pulp in the ratTakeshi Tanimoto
Department of Physiology, Nippon Dental University, School of Dentistry at Tokyo, 1 9 20 Fujimi, Chiyoda ku, Tokyo 102 8159, Japan
J Pharmacol Exp Ther 311:803-10. 2004.... - Tooth-pulp-evoked rostral spinal trigeminal neuronal excitation is attenuated by the activation of 5-HT3 receptors via GABAergic interneurons in the ratKatsuo Oshima
General Dentistry of Univ Hospital, The Nippon Dental University, School of Dentistry at Tokyo, 2 3 16, Fujimi, Chiyoda ku, Tokyo 102 8158, Japan
Brain Res 1109:70-3. 2006..The results suggest that the activation of 5-HT3 receptors elicits GABA release in the TSNO... - The inhibitory effect of ouabain on the response of slowly adapting pulmonary stretch receptors to hyperinflation in the rabbitShigeji Matsumoto
Department of Physiology, Nippon Dental University, School of Dentistry at Tokyo, 1 9 20 Fujimi, Chiyoda ku, Tokyo 102 8159, Japan
Life Sci 78:112-20. 2005..These results suggest that hyperinflation-induced SAR inhibition in the presence of ouabain may be related to a Na(+) overload, but not to a Ca(2+) influx via activation of L-type Ca(2+) channels, in the SAR endings... - Effects of acetazolamide on transient K+ currents and action potentials in nodose ganglion neurons of adult ratsShigeji Matsumoto
Department of Physiology, Nippon Dental University, School of Life Dentistry at Tokyo, 1 9 20 Fujimi, Chiyoda ku, Tokyo 102 8159, Japan
CNS Neurosci Ther 17:66-79. 2011..These results indicate that the application of AZ causes the reduction in I(A) via the inhibition of four voltage-gated K(+) channel (Kv) proteins without affecting I(D)... - Thromboxane A2 mediates cisplatin-induced apoptosis of renal tubule cellsS Jariyawat
Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Tokyo, Japan
Biochem Mol Biol Int 42:113-21. 1997..In conclusion, TXA2 appears to mediate cisplatin-induced apoptosis of S3 cells by inducing an increase in the level of c-fos mRNA expression... - The interaction and transport of beta-lactam antibiotics with the cloned rat renal organic anion transporter 1S Jariyawat
Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Mitaka, Tokyo, Japan
J Pharmacol Exp Ther 290:672-7. 1999..Furthermore, the culture cell system expressing OAT1 was revealed to be useful for the prediction of the nephrotoxicity of beta-lactam antibiotics... - Expression of somatostatin messenger RNA and receptor in cultured brain tumor cellsN Hirota
Department of Neurosurgery, Showa University School of Medicine, Tokyo, Japan
Anticancer Res 18:3295-7. 1998..Only two cell lines, GBS-1 and U87MG, expressed somatostatin mRNA, whereas somatostatin receptor was expressed in all cultured cells. These results suggest that somatostatin is an important factor for regulating cell growth... - Effects of vasopressin on isolated rat adrenal chromaffin cellsMamoru Takeda
Department of Physiology, School of Dentistry, Nippon Dental University, Tokyo, Japan
Regul Pept 106:55-65. 2002..This response pattern may be related to the expression of V(1) receptor subtypes... - Alteration of the second branch of the trigeminal nerve activity following inferior alveolar nerve transection in ratsYoshiyuki Tsuboi
Department of Physiology, School of Dentistry, Nihon University, Kanda-Surugadai, Chiyoda-ku, Tokyo 101-8310, Japan; Division of Functional Morphology, Dental Research Center, Nihon University School of Dentistry, Tokyo 101-8310, Japan
Pain 111:323-34. 2004.... - Job stress and temperaments in female nursesY Kikuchi
Department of Psychiatry, Musashino Red Cross Hospital, Tokyo, Japan
Occup Med (Lond) 63:123-8. 2013..Conclusions Nurses with depressive or anxious temperaments should be identified, monitored for signs of job stress and offered interventions to prevent adverse physical and mental effects... - Clinical efficacy and safety of donepezil on cognitive and global function in patients with Alzheimer's disease. A 24-week, multicenter, double-blind, placebo-controlled study in Japan. E2020 Study GroupA Homma
Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
Dement Geriatr Cogn Disord 11:299-313. 2000..These results indicate that the donepezil appears to be effective and well tolerated in patients with mild to moderately severe Alzheimer's disease... - Rat hepatocellular carcinogenesis and proliferating cell nuclear antigen expression induced by 3'-methyl-4-dimethylaminoazobenzeneH Ota
Second Department of Pathology, School of Medicine, Showa University, Tokyo, Japan
In Vivo 8:289-94. 1994..The present study confirms the previously reported usefulness of the PCNA immunostaining method for prognosis and assessment of the malignancy of carcinoma... - T1 and T2 squamous cell carcinomas of the floor of the mouth: results of brachytherapy mainly using 198Au grainsS Matsumoto
Department of Radiology, Tokyo Medical and Dental University, Tokyo, Japan
Int J Radiat Oncol Biol Phys 34:833-41. 1996.... - Progress in pursuit of therapeutic A2A antagonists: the adenosine A2A receptor selective antagonist KW6002: research and development toward a novel nondopaminergic therapy for Parkinson's diseaseHiroshi Kase
Kyowa Hakko Kogyo Co Ltd, Tokyo, Japan
Neurology 61:S97-100. 2003..The selective A2A antagonist should provide a novel nondopaminergic approach to PD therapy...