M Takeda

Summary

Affiliation: The Nippon Dental University
Country: Japan

Publications

  1. ncbi request reprint Changes in c-Fos expression induced by noxious stimulation in the trigeminal spinal nucleus caudalis and C1 spinal neurons of rats after hyperbaric exposure
    M Takeda
    Department of Physiology, School of Dentistry at Tokyo, Nippon Dental University, Japan
    Arch Histol Cytol 62:165-70. 1999
  2. ncbi request reprint The functional difference between transient and sustained K+ currents on the action potentials in tetrodotoxin-resistant adult rat trigeminal ganglion neurons
    Shinki Yoshida
    Department of Physiology, Nippon Dental University, School of Life Dentistry at Tokyo, Tokyo, Japan
    Brain Res 1152:64-74. 2007
  3. doi request reprint Contribution of activated interleukin receptors in trigeminal ganglion neurons to hyperalgesia via satellite glial interleukin-1beta paracrine mechanism
    Mamoru Takeda
    Department of Physiology, School of Life Dentistry at Tokyo, Nippon Dental University, 1 9 20, Fujimi cho, Chiyoda ku, Tokyo 102 8159, Japan
    Brain Behav Immun 22:1016-23. 2008
  4. doi request reprint Inflammation enhanced brain-derived neurotrophic factor-induced suppression of the voltage-gated potassium currents in small-diameter trigeminal ganglion neurons projecting to the trigeminal nucleus interpolaris/caudalis transition zone
    M Takeda
    Department of Physiology, School of Life Dentistry at Tokyo, Nippon Dental University, 1 9 20, Fujimi cho, Chiyoda ku, Tokyo 102 8159, Japan Electronic address
    Neuroscience 261:223-31. 2014
  5. ncbi request reprint Suppression of ATP-induced excitability in rat small-diameter trigeminal ganglion neurons by activation of GABAB receptor
    Mamoru Takeda
    Department of Physiology, School of Life Dentistry at Tokyo, Nippon Dental University, 1 9 20, Fujimi cho, Chiyoda ku, Tokyo 102 8159, Japan Electronic address
    Brain Res Bull 98:155-62. 2013
  6. pmc Brain-derived neurotrophic factor enhances the excitability of small-diameter trigeminal ganglion neurons projecting to the trigeminal nucleus interpolaris/caudalis transition zone following masseter muscle inflammation
    Mamoru Takeda
    Department of Physiology, School of Life Dentistry at Tokyo, Nippon Dental University, 1 9 20, Fujimi cho, Chiyoda ku, Tokyo 102 8159, Japan
    Mol Pain 9:49. 2013
  7. doi request reprint Glial cell line-derived neurotrophic factor modulates the excitability of nociceptive trigeminal ganglion neurons via a paracrine mechanism following inflammation
    Mamoru Takeda
    Department of Physiology, School of Life Dentistry at Tokyo, Nippon Dental University, 1 9 20, Fujimi cho, Chiyoda ku, Tokyo 102 8159, Japan
    Brain Behav Immun 28:100-7. 2013
  8. doi request reprint Suppression of neurokinin-1 receptor in trigeminal ganglia attenuates central sensitization following inflammation
    Mamoru Takeda
    Department of Physiology, School of Life Dentistry at Tokyo, Nippon Dental University, Tokyo, Japan
    J Peripher Nerv Syst 17:169-81. 2012
  9. pmc Alteration of primary afferent activity following inferior alveolar nerve transection in rats
    Kazuharu Nakagawa
    Department of Dysphagia Rehabilitation, Nihon University School of Dentistry, 1 8 13 Kanda Surugadai, Chiyoda ku, Tokyo, 101 8310, Japan
    Mol Pain 6:9. 2010
  10. ncbi request reprint Enhanced excitability of nociceptive trigeminal ganglion neurons by satellite glial cytokine following peripheral inflammation
    Mamoru Takeda
    Department of Physiology, School of Life Dentistry at Tokyo, Nippon Dental University, 1 9 20, Fujimi cho, Chiyoda ku, 102 8159 Tokyo, Japan
    Pain 129:155-66. 2007

Collaborators

Detail Information

Publications67

  1. ncbi request reprint Changes in c-Fos expression induced by noxious stimulation in the trigeminal spinal nucleus caudalis and C1 spinal neurons of rats after hyperbaric exposure
    M Takeda
    Department of Physiology, School of Dentistry at Tokyo, Nippon Dental University, Japan
    Arch Histol Cytol 62:165-70. 1999
    ..These results suggest that hyperbaric exposure may attenuate nociceptive signals from the area innervated by the trigeminal nerves at the level of both the trigeminal spinal nucleus caudalis and C1 dorsal horn...
  2. ncbi request reprint The functional difference between transient and sustained K+ currents on the action potentials in tetrodotoxin-resistant adult rat trigeminal ganglion neurons
    Shinki Yoshida
    Department of Physiology, Nippon Dental University, School of Life Dentistry at Tokyo, Tokyo, Japan
    Brain Res 1152:64-74. 2007
    ..These results suggested that I(A) and I(K) had independent effects regulating the intrinsic firing properties of the action potential number and timing, respectively, in adult rat TTX-R TG neurons...
  3. doi request reprint Contribution of activated interleukin receptors in trigeminal ganglion neurons to hyperalgesia via satellite glial interleukin-1beta paracrine mechanism
    Mamoru Takeda
    Department of Physiology, School of Life Dentistry at Tokyo, Nippon Dental University, 1 9 20, Fujimi cho, Chiyoda ku, Tokyo 102 8159, Japan
    Brain Behav Immun 22:1016-23. 2008
    ..Such an IL-1beta release could be important in determining trigeminal inflammatory hyperalgesia...
  4. doi request reprint Inflammation enhanced brain-derived neurotrophic factor-induced suppression of the voltage-gated potassium currents in small-diameter trigeminal ganglion neurons projecting to the trigeminal nucleus interpolaris/caudalis transition zone
    M Takeda
    Department of Physiology, School of Life Dentistry at Tokyo, Nippon Dental University, 1 9 20, Fujimi cho, Chiyoda ku, Tokyo 102 8159, Japan Electronic address
    Neuroscience 261:223-31. 2014
    ..These findings support the development of voltage-gated K(+) channel openers and tyrosine kinase inhibitors as potential therapeutic agents for the treatment of trigeminal inflammatory hyperalgesia. ..
  5. ncbi request reprint Suppression of ATP-induced excitability in rat small-diameter trigeminal ganglion neurons by activation of GABAB receptor
    Mamoru Takeda
    Department of Physiology, School of Life Dentistry at Tokyo, Nippon Dental University, 1 9 20, Fujimi cho, Chiyoda ku, Tokyo 102 8159, Japan Electronic address
    Brain Res Bull 98:155-62. 2013
    ..Thus, the interaction between P2X3 and GABAB receptors of small-diameter TRG neuronal cell bodies is a potential therapeutic target for the treatment of trigeminal nociception...
  6. pmc Brain-derived neurotrophic factor enhances the excitability of small-diameter trigeminal ganglion neurons projecting to the trigeminal nucleus interpolaris/caudalis transition zone following masseter muscle inflammation
    Mamoru Takeda
    Department of Physiology, School of Life Dentistry at Tokyo, Nippon Dental University, 1 9 20, Fujimi cho, Chiyoda ku, Tokyo 102 8159, Japan
    Mol Pain 9:49. 2013
    ....
  7. doi request reprint Glial cell line-derived neurotrophic factor modulates the excitability of nociceptive trigeminal ganglion neurons via a paracrine mechanism following inflammation
    Mamoru Takeda
    Department of Physiology, School of Life Dentistry at Tokyo, Nippon Dental University, 1 9 20, Fujimi cho, Chiyoda ku, Tokyo 102 8159, Japan
    Brain Behav Immun 28:100-7. 2013
    ..GDNF paracrine mechanism could be important as a therapeutic target for trigeminal inflammatory hyperalgesia...
  8. doi request reprint Suppression of neurokinin-1 receptor in trigeminal ganglia attenuates central sensitization following inflammation
    Mamoru Takeda
    Department of Physiology, School of Life Dentistry at Tokyo, Nippon Dental University, Tokyo, Japan
    J Peripher Nerv Syst 17:169-81. 2012
    ..These results suggest that in the early stages of inflammation suppression of the NK1 receptor mechanism in TRGs may prevent central sensitization of SpVc nociceptive neurons...
  9. pmc Alteration of primary afferent activity following inferior alveolar nerve transection in rats
    Kazuharu Nakagawa
    Department of Dysphagia Rehabilitation, Nihon University School of Dentistry, 1 8 13 Kanda Surugadai, Chiyoda ku, Tokyo, 101 8310, Japan
    Mol Pain 6:9. 2010
    ..In order to evaluate the neural mechanisms underlying the abnormal facial pain that may develop following regeneration of the injured inferior alveolar nerve (IAN), the properties of the IAN innervated in the mental region were analyzed...
  10. ncbi request reprint Enhanced excitability of nociceptive trigeminal ganglion neurons by satellite glial cytokine following peripheral inflammation
    Mamoru Takeda
    Department of Physiology, School of Life Dentistry at Tokyo, Nippon Dental University, 1 9 20, Fujimi cho, Chiyoda ku, 102 8159 Tokyo, Japan
    Pain 129:155-66. 2007
    ..Therefore IL-1beta blockers are potential therapeutic agents for prevention of trigeminal hyperalgesia...
  11. ncbi request reprint Temporomandibular joint inflammation potentiates the excitability of trigeminal root ganglion neurons innervating the facial skin in rats
    Mamoru Takeda
    Department of Physiology, School of Dentistry at Tokyo, Nippon Dental University, 1 9 20, Fujimi cho, Chiyoda ku, Tokyo 102 8159, Japan
    J Neurophysiol 93:2723-38. 2005
    ....
  12. ncbi request reprint Role of capsaicin-sensitive primary afferent inputs from the masseter muscle in the C1 spinal neurons responding to tooth-pulp stimulation in rats
    M Takeda
    Department of Physiology, School of Dentistry at Tokyo, Nippon Dental University, 1 9 20, Fujimi cho, Chiyoda ku, 102 8159 Tokyo, Japan
    Exp Brain Res 160:107-17. 2005
    ....
  13. doi request reprint Glial cell line-derived neurotrophic factor acutely modulates the excitability of rat small-diameter trigeminal ganglion neurons innervating facial skin
    Mamoru Takeda
    Department of Physiology, School of Life Dentistry at Tokyo, Nippon Dental University, 1 9 20, Fujimi cho, Chiyoda ku, Tokyo 102 8159, Japan
    Brain Behav Immun 24:72-82. 2010
    ..We therefore conclude that a local release of GDNF from TRG neuronal soma and/or nerve terminals may regulate normal sensory function, including nociception...
  14. doi request reprint Contribution of the activation of satellite glia in sensory ganglia to pathological pain
    Mamoru Takeda
    Department of Physiology, School of Life Dentistry at Tokyo, Nippon Dental University, Chiyoda ku, Tokyo, Japan
    Neurosci Biobehav Rev 33:784-92. 2009
    ..In addition, we discuss potential therapeutic targets in satellite glia-neuronal interactions for the prevention of pathological pain...
  15. doi request reprint Systemic administration of lidocaine suppresses the excitability of rat cervical dorsal horn neurons and tooth-pulp-evoked jaw-opening reflex
    Mamoru Takeda
    Department of Physiology, School of Life Dentistry at Tokyo, Nippon Dental University, Tokyo, Japan
    Eur J Pain 13:929-34. 2009
    ..Systemic lidocaine administration, therefore, may contribute to the alleviation of trigeminal-referred pain associated with tooth pain...
  16. ncbi request reprint Activation of NK1 receptor of trigeminal root ganglion via substance P paracrine mechanism contributes to the mechanical allodynia in the temporomandibular joint inflammation in rats
    Mamoru Takeda
    Department of Physiology, School of Dentistry at Tokyo, Nippon Dental University, Tokyo, 102 8159, Japan
    Pain 116:375-85. 2005
    ..Such a SP release may play an important role in determining the trigeminal inflammatory allodynia concerning the temporomandibular disorder...
  17. ncbi request reprint Temporomandibular joint inflammation decreases the voltage-gated K+ channel subtype 1.4-immunoreactivity of trigeminal ganglion neurons in rats
    Mamoru Takeda
    Department of Physiology, Nippon Dental University, 1 9 20, Fujimi cho, Chiyoda ku, Tokyo 102 8159, Japan
    Eur J Pain 12:189-95. 2008
    ..These results lead us to suggest that Kv channel openers may be a potential therapeutic agents for prevention of mechanical allodynia...
  18. ncbi request reprint Enhanced excitability of rat trigeminal root ganglion neurons via decrease in A-type potassium currents following temporomandibular joint inflammation
    M Takeda
    Department of Physiology, School of Dentistry at Tokyo, Nippon Dental University, 1 9 20, Fujimi cho, Chiyoda ku, Tokyo 102 8159, Japan
    Neuroscience 138:621-30. 2006
    ..These changes may contribute to trigeminal inflammatory allodynia in temporomandibular joint disorder...
  19. ncbi request reprint Activation of alpha2-adrenoreceptors suppresses the excitability of C1 spinal neurons having convergent inputs from tooth pulp and superior sagittal sinus in rats
    M Takeda
    Department of Physiology, School of Dentistry at Tokyo, Nippon Dental University, 1 9 20 Fujimi cho, Chiyoda ku, Tokyo, 102 8159, Japan
    Exp Brain Res 174:210-20. 2006
    ....
  20. doi request reprint Activation of interleukin-1beta receptor suppresses the voltage-gated potassium currents in the small-diameter trigeminal ganglion neurons following peripheral inflammation
    Mamoru Takeda
    Department of Physiology, Nippon Dental University, Fujimi cho, Chiyoda ku, Tokyo, Japan
    Pain 139:594-602. 2008
    ..These findings provide evidence for the development of voltage-gated K(+) channel openers and IL-1beta antagonists as therapeutic agents for the treatment of trigeminal inflammatory hyperalgesia...
  21. ncbi request reprint N-methyl-D-aspartate (NMDA) and non-NMDA receptor antagonists suppress the superior sagittal sinus-evoked activity of C1 spinal neurons responding to tooth pulp electrical stimulation in rats
    Yoshinobu Fujimi
    Department of Physiology, The Nippon Dental University School of Life Dentistry at Tokyo, 1 9 20 Fujimi, Chiyoda ku, Tokyo, 102 8159, Japan
    Odontology 94:22-8. 2006
    ....
  22. ncbi request reprint Somatostatin inhibits the excitability of rat small-diameter trigeminal ganglion neurons that innervate nasal mucosa and project to the upper cervical dorsal horn via activation of somatostatin 2a receptor
    M Takeda
    Department of Physiology, School of Life Dentistry at Tokyo, Nippon Dental University, 1 9 20, Fujimi cho, Chiyoda ku, Tokyo 102 8159, Japan
    Neuroscience 148:744-56. 2007
    ....
  23. ncbi request reprint Opioidergic modulation of excitability of rat trigeminal root ganglion neuron projections to the superficial layer of cervical dorsal horn
    M Takeda
    Department of Physiology, School of Dentistry at Tokyo, Nippon Dental University, 1 9 20, Fujimi cho, Chiyoda ku, Tokyo, 102 8159 Japan
    Neuroscience 125:995-1008. 2004
    ....
  24. ncbi request reprint Activaton of GABAB receptor inhibits the excitability of rat small diameter trigeminal root ganglion neurons
    M Takeda
    Department of Physiology, School of Dentistry at Tokyo, Nippon Dental University, 1 9 20, Fujimi cho, Chiyoda ku, Tokyo, 102 8159, Japan
    Neuroscience 123:491-505. 2004
    ....
  25. pmc In vivo patch-clamp analysis of response properties of rat primary somatosensory cortical neurons responding to noxious stimulation of the facial skin
    Mamoru Takeda
    Department of Physiology, School of Life Dentistry at Tokyo, Nippon Dental University, 1 9 20, Fujimi cho, Chiyoda ku, Tokyo, 102 8159, Japan
    Mol Pain 6:30. 2010
    ..The aim of the present study was to examine whether noxious stimulation applied to the orofacial area evokes the synaptic response of SI neurons in urethane-anesthetized rats using an in vivo patch-clamp technique...
  26. ncbi request reprint Effects of GABA(A) and glycine receptor agonists on the medullary inspiratory neuronal activity during spontaneous augmented breaths in anesthetized rats
    Mamoru Takeda
    Department of Physiology, Nippon Dental University, School of Dentistry at Tokyo, 1 9 20, Fujimi cho, Chiyoda ku, Japan
    Life Sci 71:2681-90. 2002
    ..These results suggested that the excitatory inputs to inspiratory neurons during the phase II of augmented breaths may not be significantly influenced by the activation of either GABA(A) receptors or glycine receptors...
  27. ncbi request reprint Change in mechanical receptive field properties induced by GABA(A) receptor activation in the trigeminal spinal nucleus caudalis neurons in rats
    M Takeda
    Department of Physiology, Nippon Dental University, School of Dentistry at Tokyo, Japan
    Exp Brain Res 134:409-16. 2000
    ....
  28. ncbi request reprint Peripheral inflammation suppresses inward rectifying potassium currents of satellite glial cells in the trigeminal ganglia
    Mamoru Takeda
    Department of Physiology, School of Life Dentistry at Tokyo, Nippon Dental University, 1 9 20, Fujimi cho, Chiyoda ku, Tokyo 102 8159, Japan
    Pain 152:2147-56. 2011
    ..Therefore, the Kir4.1 channel in SGCs may be a new molecular target for the treatment of trigeminal inflammatory pain...
  29. ncbi request reprint Volume expansion suppresses the tooth-pulp evoked jaw-opening reflex related activity of trigeminal neurons in rats
    Mamoru Takeda
    Department of Physiology, School of Dentistry at Tokyo, Nippon Dental University, Tokyo, Japan
    Brain Res Bull 58:83-9. 2002
    ..These results therefore suggest that low-pressure cardiopulmonary baroreceptors whose afferents travel in the vagus nerve inhibit the pulpal nociceptive transmission...
  30. ncbi request reprint Effects of gadolinium and tetrodotoxin on the response of slowly adapting type I mechanoreceptors to mechanical stimulation in frog dorsal skin
    Mamoru Takeda
    Department of Physiology, School of Dentistry at Tokyo, Nippon Dental University, Tokyo, Japan
    J Peripher Nerv Syst 8:271-81. 2003
    ....
  31. pmc Potassium channels as a potential therapeutic target for trigeminal neuropathic and inflammatory pain
    Mamoru Takeda
    Department of Physiology, School of Life Dentistry at Tokyo, Nippon Dental University, 1 9 20 Fujimi cho, Chiyoda ku, Tokyo, Japan
    Mol Pain 7:5. 2011
    ..We also discuss the potential of Kv channel openers as therapeutic agents for trigeminal neuropathic/inflammatory pain, such as mechanical allodynia...
  32. ncbi request reprint Changes of the excitability of rat trigeminal root ganglion neurons evoked by alpha(2)-adrenoreceptors
    M Takeda
    Department of Physiology, School of Dentistry at Tokyo, Nippon Dental University, 1 9 20 Fujimi cho, Chiyoda ku, Tokyo 102 8159, Japan
    Neuroscience 115:731-41. 2002
    ....
  33. ncbi request reprint Suppressive effect of vagal afferents on cervical dorsal horn neurons responding to tooth pulp electrical stimulation in the rat
    T Tanimoto
    Department of Physiology, Nippon Dental University, School of Dentistry at Tokyo, 1 9 20 Fujimi, Chiyoda ku, Tokyo 102 8159, Japan
    Exp Brain Res 145:468-79. 2002
    ..These results suggest that VA stimulation inhibits nociceptive transmission in the C1 spinal neuron activity via the activation of both noradrenergic and serotonergic (5-HT(3)) descending inhibitory systems...
  34. doi request reprint Somatostatin inhibits tooth-pulp-evoked rat cervical dorsal horn neuronal activity
    M Takahashi
    Department of Physiology, School of Life Dentistry at Tokyo, Nippon Dental University, 1 9 20 Fujimi, Tokyo, 102 8159 Japan
    Exp Brain Res 184:617-22. 2008
    ..These results suggest that a local release of SST modulates the TP-evoked C(1) neuronal activity and this may contribute to a useful therapeutic target for the alleviation of tooth pain and trigeminal hyperalgesia...
  35. doi request reprint Excitability of small-diameter trigeminal ganglion neurons by 5-HT is mediated by enhancement of the tetrodotoxin-resistant sodium current due to the activation of 5-HT(4) receptors and/or by the inhibition of the transient potassium current
    Y Tsutsui
    Department of Physiology, Nippon Dental University, School of Life Dentistry at Tokyo, 1 9 20 Fujimi, Chiyoda ku, Tokyo 102 8159, Japan
    Neuroscience 157:683-96. 2008
    ....
  36. ncbi request reprint Prostaglandin E2 potentiates the excitability of small diameter trigeminal root ganglion neurons projecting onto the superficial layer of the cervical dorsal horn in rats
    Jun Kadoi
    Department of Physiology, Nippon Dental University, School of Dentistry at Tokyo, 1 9 20, Fujimi cho, Chiyoda ku, Tokyo, 102 8159, Japan
    Exp Brain Res 176:227-36. 2007
    ..These results suggest that the excitability of small diameter TRG neurons seen after 1 microM PGE2 application is involved in an increase in the..
  37. ncbi request reprint Effects of acetazolamide and 4-aminoprydine on the responses of deflationary slowly adapting pulmonary stretch receptors to CO2 inhalation in the rat
    S Matsumoto
    Department of Physiology, Nippon Dental University, School of Dentistry at Tokyo, 1 9 20 Fujimi, Chiyoda ku, Tokyo 102 8159, Japan
    Life Sci 72:1757-71. 2003
    ..These results suggest that inhibition of deflationary SARs by CO(2) inhalation may be largely mediated by the stimulating action of 4-AP-sensitive K(+) currents in the nerve terminals of the receptors...
  38. ncbi request reprint Effects of potassium channel blockers on hyperinflation-induced rapidly adapting pulmonary stretch receptor stimulation in the rabbit
    S Matsumoto
    Department of Physiology, Nippon Dental University, School of Dentistry at Tokyo, Japan
    Life Sci 70:491-501. 2001
    ....
  39. ncbi request reprint Role of organic anion transporter 1 (OAT1) in cephaloridine (CER)-induced nephrotoxicity
    M Takeda
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Tokyo, Japan
    Kidney Int 56:2128-36. 1999
    ..Role of organic anion transporter 1 (OAT1) in cephaloridine (CER)-induced nephrotoxicity...
  40. pmc Effects of potassium channel and Na+-Ca2+ exchange blockers on the responses of slowly adapting pulmonary stretch receptors to hyperinflation in flecainide-treated rats
    S Matsumoto
    Department of Physiology, Nippon Dental University, School of Dentistry at Tokyo, 1-9-20 Fujimi, Chiyoda-ku, Tokyo 102-8159, Japan
    Br J Pharmacol 134:682-90. 2001
    ..4. These results suggest that hyperinflation-induced SAR inhibition in the presence of flecainide (9 mg kg(-1)) involves the activation of several K(+) conductance pathways...
  41. ncbi request reprint Mechanisms involved in modulation of trigeminal primary afferent activity in rats with peripheral mononeuropathy
    Junichi Kitagawa
    Department of Physiology, School of Dentistry, Nihon University, 1 8 13 Kandasurugadai, Chiyoda ku Tokyo, 101 8310, Japan
    Eur J Neurosci 24:1976-86. 2006
    ....
  42. pmc Prostaglandin E2-induced modification of tetrodotoxin-resistant Na+ currents involves activation of both EP2 and EP4 receptors in neonatal rat nodose ganglion neurones
    Shigeji Matsumoto
    Department of Physiology, Nippon Dental University, School of Dentistry at Tokyo, 1 9 20 Fujimi, Chiyoda ku, Tokyo 102 8159, Japan
    Br J Pharmacol 145:503-13. 2005
    ..7 These results suggest that the PGE2-induced modification of I(NaR) is mainly mediated by activation of both EP2 and EP4 receptors...
  43. ncbi request reprint Effect of sodium benzylideneascorbate on chemically-induced tumors in rats
    H Sakagami
    First Department of Biochemistry, School of Medicine, Showa University, Tokyo, Japan
    Anticancer Res 13:65-71. 1993
    ..These data suggest that the conditions of SBA administration should be re-established for each tumor sample to produce maximum antitumor activity...
  44. ncbi request reprint The roles of I(D), I(A) and I(K) in the electrophysiological functions of small diameter rat trigeminal ganglion neurons
    Shigeji Matsumoto
    Department of Physiology, Nippon Dental University, School of Life Dentistry at Tokyo, Tokyo, Japan
    Curr Mol Pharmacol 3:30-6. 2010
    ..Thus, reducing effects of both I(A) and I(K) may be useful to investigate the mechanism of allodynia...
  45. doi request reprint Flecainide inhibits the stimulatory effect of veratridine on the response of airway mechanoreceptors to maintained inflations in rats
    Shigeji Matsumoto
    Department of Physiology, Nippon Dental University, School of Life Dentistry at Tokyo, 1 9 20 Fujimi, Chiyoda ku, Tokyo 102 8159, Japan
    Life Sci 87:411-9. 2010
    ....
  46. ncbi request reprint The effects of ouabain on resting membrane potential and hyperpolarization-activated current in neonatal rat nodose ganglion neurons
    Shigeji Matsumoto
    Department of Physiology, Nippon Dental University, School of Life Dentistry at Tokyo, 1 9 20 Fujimi, Chiyoda ku, Tokyo 102 8159, Japan
    Neurosci Lett 439:241-4. 2008
    ..These results suggest that ouabain application at 1microM is capable of setting both the RMP level and the neuronal excitability in small-diameter NG neurons...
  47. ncbi request reprint Effect of 8-bromo-cAMP on the tetrodotoxin-resistant sodium (Nav 1.8) current in small-diameter nodose ganglion neurons
    Shigeji Matsumoto
    Department of Physiology, Nippon Dental University, School of Dentistry at Tokyo, 1 9 20 Fujimi, Chiyoda ku, Tokyo 102 8159, Japan
    Neuropharmacology 52:904-24. 2007
    ..8 current amplitude and further enhanced the Ro-31-8425-induced decrease in the current. These results suggest that the 8-Br-cAMP-induced increase in Nav 1.8 currents may be mediated by activation of both PKA and PKC...
  48. ncbi request reprint The role of 5-hydroxytryptamine3 receptors in the vagal afferent activation-induced inhibition of the first cervical dorsal horn spinal neurons projected from tooth pulp in the rat
    Takeshi Tanimoto
    Department of Physiology, Nippon Dental University, School of Dentistry at Tokyo, 1 9 20 Fujimi, Chiyoda ku, Tokyo 102 8159, Japan
    J Pharmacol Exp Ther 311:803-10. 2004
    ....
  49. ncbi request reprint Excitatory mechanism of deflationary slowly adapting pulmonary stretch receptors in the rat lung
    Shigeji Matsumoto
    Department of Physiology, Nippon Dental University, School of Dentistry at Tokyo, Tokyo, Japan
    J Pharmacol Exp Ther 300:597-604. 2002
    ..0 and 6.0 mg/kg). These results suggest that the excitatory effect of lung deflation on deflationary SAR activity is mediated by the activation of flecainide-sensitive Na(+) channels on the nerve terminals of deflationary SARs...
  50. ncbi request reprint Tooth-pulp-evoked rostral spinal trigeminal nucleus neuron activity is inhibited by conditioning sciatic nerve stimulation in the rat: possible role of 5-HT3 receptor mediated GABAergic inhibition
    Katsuo Oshima
    General Dentistry of University Hospital, The Nippon Dental University, School of Dentistry at Tokyo, Chiyoda ku, Tokyo 102 8158, Japan
    Brain Res Bull 65:31-40. 2005
    ....
  51. ncbi request reprint Immunohistochemical co-expression of carbonic anhydrase II with Kv1.4 and TRPV1 in rat small-diameter trigeminal ganglion neurons
    Takeshi Tanimoto
    Department of Physiology, Nippon Dental University, School of Dentistry at Tokyo, 1 9 20 Fujimi, Tokyo 102 8159, Japan
    Brain Res 1044:262-5. 2005
    ..The fact that CAII-immunoreactive TG neurons revealed a common expression of both Kv1.4 and TRPV1 leads us to suggest that CAII may be one of the nociceptive neuronal markers...
  52. ncbi request reprint The inhibitory effect of ouabain on the response of slowly adapting pulmonary stretch receptors to hyperinflation in the rabbit
    Shigeji Matsumoto
    Department of Physiology, Nippon Dental University, School of Dentistry at Tokyo, 1 9 20 Fujimi, Chiyoda ku, Tokyo 102 8159, Japan
    Life Sci 78:112-20. 2005
    ..These results suggest that hyperinflation-induced SAR inhibition in the presence of ouabain may be related to a Na(+) overload, but not to a Ca(2+) influx via activation of L-type Ca(2+) channels, in the SAR endings...
  53. ncbi request reprint Effect of ouabain on the afterhyperpolarization of slowly adapting pulmonary stretch receptors in the rat lung
    Shigeji Matsumoto
    Department of Physiology, Nippon Dental University, School of Dentistry at Tokyo, 1 9 20 Fujimi, Chiyoda ku, Tokyo 102 8159, Japan
    Brain Res 1107:131-9. 2006
    ..These results suggest that the mechanism of generating the AHP of SARs is mainly mediated by the activation of Na+-K+ ATPase alpha3 subunit isoform...
  54. ncbi request reprint Tooth-pulp-evoked rostral spinal trigeminal neuronal excitation is attenuated by the activation of 5-HT3 receptors via GABAergic interneurons in the rat
    Katsuo Oshima
    General Dentistry of Univ Hospital, The Nippon Dental University, School of Dentistry at Tokyo, 2 3 16, Fujimi, Chiyoda ku, Tokyo 102 8158, Japan
    Brain Res 1109:70-3. 2006
    ..The results suggest that the activation of 5-HT3 receptors elicits GABA release in the TSNO...
  55. ncbi request reprint Convergence of nociceptive information from temporomandibular joint and tooth pulp afferents on C1 spinal neurons in the rat
    Toshimi Nishikawa
    Department of Physiology, Nippon Dental University, School of Dentistry at Tokyo, 1 9 20 Fujimi, Chiyoda ku, Tokyo 102 8159, Japan
    Life Sci 75:1465-78. 2004
    ..These results suggest that there is a convergence of noxious information from the TMJ and TP afferents on the same C1 spinal neurons, which importantly contribute to pain perception from the TMJ region...
  56. ncbi request reprint Effects of acetazolamide and 4-aminopyridine on CO2-induced slowly adapting pulmonary stretch receptor inhibition in rats
    Shigeji Matsumoto
    Department of Physiology, Nippon Dental University, School of Dentistry at Tokyo, 1 9 20 Fujimi, Chiyoda ku, Tokyo 102 8159, Japan
    Chem Senses 29:351-61. 2004
    ..These results suggest that CO(2)-induced inhibition of SARs may be involved in the CA-dependent CO(2) hydration in addition to the activation of 4-AP sensitive K(+) currents...
  57. pmc Effects of acetazolamide on transient K+ currents and action potentials in nodose ganglion neurons of adult rats
    Shigeji Matsumoto
    Department of Physiology, Nippon Dental University, School of Life Dentistry at Tokyo, 1 9 20 Fujimi, Chiyoda ku, Tokyo 102 8159, Japan
    CNS Neurosci Ther 17:66-79. 2011
    ..These results indicate that the application of AZ causes the reduction in I(A) via the inhibition of four voltage-gated K(+) channel (Kv) proteins without affecting I(D)...
  58. ncbi request reprint Thromboxane A2 mediates cisplatin-induced apoptosis of renal tubule cells
    S Jariyawat
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Tokyo, Japan
    Biochem Mol Biol Int 42:113-21. 1997
    ..In conclusion, TXA2 appears to mediate cisplatin-induced apoptosis of S3 cells by inducing an increase in the level of c-fos mRNA expression...
  59. ncbi request reprint The interaction and transport of beta-lactam antibiotics with the cloned rat renal organic anion transporter 1
    S Jariyawat
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Mitaka, Tokyo, Japan
    J Pharmacol Exp Ther 290:672-7. 1999
    ..Furthermore, the culture cell system expressing OAT1 was revealed to be useful for the prediction of the nephrotoxicity of beta-lactam antibiotics...
  60. ncbi request reprint Expression of somatostatin messenger RNA and receptor in cultured brain tumor cells
    N Hirota
    Department of Neurosurgery, Showa University School of Medicine, Tokyo, Japan
    Anticancer Res 18:3295-7. 1998
    ..Only two cell lines, GBS-1 and U87MG, expressed somatostatin mRNA, whereas somatostatin receptor was expressed in all cultured cells. These results suggest that somatostatin is an important factor for regulating cell growth...
  61. ncbi request reprint Effects of vasopressin on isolated rat adrenal chromaffin cells
    Mamoru Takeda
    Department of Physiology, School of Dentistry, Nippon Dental University, Tokyo, Japan
    Regul Pept 106:55-65. 2002
    ..This response pattern may be related to the expression of V(1) receptor subtypes...
  62. ncbi request reprint Alteration of the second branch of the trigeminal nerve activity following inferior alveolar nerve transection in rats
    Yoshiyuki Tsuboi
    Department of Physiology, School of Dentistry, Nihon University, Kanda Surugadai, Chiyoda ku, Tokyo 101 8310, Japan Division of Functional Morphology, Dental Research Center, Nihon University School of Dentistry, Tokyo 101 8310, Japan
    Pain 111:323-34. 2004
    ....
  63. doi request reprint Job stress and temperaments in female nurses
    Y Kikuchi
    Department of Psychiatry, Musashino Red Cross Hospital, Tokyo, Japan
    Occup Med (Lond) 63:123-8. 2013
    ..According to previous studies, temperament predicts a large share of the variance in job stress. It may be necessary for mental health practitioners to offer intervention strategies in accordance with individual temperament...
  64. ncbi request reprint Progress in pursuit of therapeutic A2A antagonists: the adenosine A2A receptor selective antagonist KW6002: research and development toward a novel nondopaminergic therapy for Parkinson's disease
    Hiroshi Kase
    Kyowa Hakko Kogyo Co Ltd, Tokyo, Japan
    Neurology 61:S97-100. 2003
    ..The selective A2A antagonist should provide a novel nondopaminergic approach to PD therapy...
  65. ncbi request reprint Rat hepatocellular carcinogenesis and proliferating cell nuclear antigen expression induced by 3'-methyl-4-dimethylaminoazobenzene
    H Ota
    Second Department of Pathology, School of Medicine, Showa University, Tokyo, Japan
    In Vivo 8:289-94. 1994
    ..The present study confirms the previously reported usefulness of the PCNA immunostaining method for prognosis and assessment of the malignancy of carcinoma...
  66. ncbi request reprint Clinical efficacy and safety of donepezil on cognitive and global function in patients with Alzheimer's disease. A 24-week, multicenter, double-blind, placebo-controlled study in Japan. E2020 Study Group
    A Homma
    Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Dement Geriatr Cogn Disord 11:299-313. 2000
    ..These results indicate that the donepezil appears to be effective and well tolerated in patients with mild to moderately severe Alzheimer's disease...
  67. ncbi request reprint T1 and T2 squamous cell carcinomas of the floor of the mouth: results of brachytherapy mainly using 198Au grains
    S Matsumoto
    Department of Radiology, Tokyo Medical and Dental University, Tokyo, Japan
    Int J Radiat Oncol Biol Phys 34:833-41. 1996
    ....