Eiji Takeda

Summary

Affiliation: The University of Tokushima
Country: Japan

Publications

  1. ncbi request reprint Phosphate restriction in diet therapy
    Eiji Takeda
    Department of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan
    Contrib Nephrol 155:113-24. 2007
  2. ncbi request reprint Control of oxidative stress and metabolic homeostasis by the suppression of postprandial hyperglycemia
    Eiji Takeda
    Department of Clinical Nutrition, Institute of Health Biosciences, and The University of Tokushima Graduate School, Japan
    J Med Invest 52:259-65. 2005
  3. pmc Improvement of glucose metabolism in patients with impaired glucose tolerance or diabetes by long-term administration of a palatinose-based liquid formula as a part of breakfast
    Masae Sakuma
    Departments of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School, 3 18 15 Kuramoto, Tokushima 770 8503, Japan
    J Clin Biochem Nutr 45:155-62. 2009
  4. ncbi request reprint Dietary phosphorus in bone health and quality of life
    Eiji Takeda
    Department of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan
    Nutr Rev 70:311-21. 2012
  5. ncbi request reprint Inorganic phosphate homeostasis and the role of dietary phosphorus
    Eiji Takeda
    Department of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School, Kuramoto cho 3 18 15, Tokushima, 770 8503, Japan
    J Cell Mol Med 8:191-200. 2004
  6. ncbi request reprint The regulation and function of phosphate in the human body
    Eiji Takeda
    Department of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan
    Biofactors 21:345-55. 2004
  7. ncbi request reprint Gene expression in low glycemic index diet - impact on metabolic control
    Eiji Takeda
    Department of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan
    Forum Nutr 60:127-39. 2007
  8. ncbi request reprint Sodium-dependent phosphate co-transporters
    E Takeda
    Department of Clinical Nutrition, School of Medicine, University of Tokushima, Japan
    Int J Biochem Cell Biol 31:377-81. 1999
  9. ncbi request reprint Phosphorus supply per capita from food in Japan between 1960 and 1995
    Eiji Takeda
    Department of Clinical Nutrition, School of Medicine, The University of Tokushima, Japan
    J Nutr Sci Vitaminol (Tokyo) 48:102-8. 2002
  10. doi request reprint Dietary phosphate restriction induces hepatic lipid accumulation through dysregulation of cholesterol metabolism in mice
    Sarasa Tanaka
    Department of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima 770 8503, Japan
    Nutr Res 33:586-93. 2013

Detail Information

Publications98

  1. ncbi request reprint Phosphate restriction in diet therapy
    Eiji Takeda
    Department of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan
    Contrib Nephrol 155:113-24. 2007
    ..8 g/kg body weight/day for a 60 kg patient. Target levels should become 9.2-9.6 mg/dl for calcium, 2.5-5.5 mg/dl for phosphorus, <55 mg2/dl2 for the calcium-phosphorus product, and 100-200 pg/ml for intact parathyroid hormone...
  2. ncbi request reprint Control of oxidative stress and metabolic homeostasis by the suppression of postprandial hyperglycemia
    Eiji Takeda
    Department of Clinical Nutrition, Institute of Health Biosciences, and The University of Tokushima Graduate School, Japan
    J Med Invest 52:259-65. 2005
    ..Therefore, it is suggested that functional food which suppresses postprandial glucose level is beneficial for both stress and metabolic controls...
  3. pmc Improvement of glucose metabolism in patients with impaired glucose tolerance or diabetes by long-term administration of a palatinose-based liquid formula as a part of breakfast
    Masae Sakuma
    Departments of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School, 3 18 15 Kuramoto, Tokushima 770 8503, Japan
    J Clin Biochem Nutr 45:155-62. 2009
    ..Intake of 1046 kJ palatinose-formula as a part of breakfast over a long-term period may be effective for improvement of glucose metabolism in patients with IGT or type 2 diabetes...
  4. ncbi request reprint Dietary phosphorus in bone health and quality of life
    Eiji Takeda
    Department of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan
    Nutr Rev 70:311-21. 2012
    ....
  5. ncbi request reprint Inorganic phosphate homeostasis and the role of dietary phosphorus
    Eiji Takeda
    Department of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School, Kuramoto cho 3 18 15, Tokushima, 770 8503, Japan
    J Cell Mol Med 8:191-200. 2004
    ..In considering the relationship of klotho expression to the dietary Pi level, the klotho protein seemed to be negatively controlled by dietary Pi...
  6. ncbi request reprint The regulation and function of phosphate in the human body
    Eiji Takeda
    Department of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan
    Biofactors 21:345-55. 2004
    ..It is thought that excess amounts of phosphorus intake for long periods are a strong factor in bone impairment and ageing. The restriction of phosphorus intake seems to be important under low calcium intake to keep QOL on high level...
  7. ncbi request reprint Gene expression in low glycemic index diet - impact on metabolic control
    Eiji Takeda
    Department of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan
    Forum Nutr 60:127-39. 2007
    ..Correcting postprandial hyperglycemia forms an important part of the prevention and management of type 2 diabetes...
  8. ncbi request reprint Sodium-dependent phosphate co-transporters
    E Takeda
    Department of Clinical Nutrition, School of Medicine, University of Tokushima, Japan
    Int J Biochem Cell Biol 31:377-81. 1999
    ..The regulation of phosphatonin and Na+/Pi co-transporters may provide novel pharmacological approaches to the treatment of these diseases...
  9. ncbi request reprint Phosphorus supply per capita from food in Japan between 1960 and 1995
    Eiji Takeda
    Department of Clinical Nutrition, School of Medicine, The University of Tokushima, Japan
    J Nutr Sci Vitaminol (Tokyo) 48:102-8. 2002
    ....
  10. doi request reprint Dietary phosphate restriction induces hepatic lipid accumulation through dysregulation of cholesterol metabolism in mice
    Sarasa Tanaka
    Department of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima 770 8503, Japan
    Nutr Res 33:586-93. 2013
    ..These results suggest that dietary Pi plays an important role in the development of fatty liver disease and hyperlipidemia induced by a high-cholesterol diet through regulation of lipid metabolism-related gene expression in the liver. ..
  11. pmc Dietary phosphorus acutely impairs endothelial function
    Emi Shuto
    Department of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School, 3 18 15, Kuramoto Cho, Tokushima 770 8503, Japan
    J Am Soc Nephrol 20:1504-12. 2009
    ....
  12. ncbi request reprint Palatinose and oleic acid act together to prevent pancreatic islet disruption in nondiabetic obese Zucker rats
    Kazusa Sato
    Department of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan
    J Med Invest 55:183-95. 2008
    ..These findings suggest that pancreatic islets may be initial sites that translate the effects of different combinations of dietary carbohydrates and fats into metabolic changes...
  13. doi request reprint Liver X receptor negatively regulates fibroblast growth factor 21 in the fatty liver induced by cholesterol-enriched diet
    Takashi Uebanso
    Department of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima 770 8503, Japan
    J Nutr Biochem 23:785-90. 2012
    ..In summary, LXR represses FGF21 gene expression at the transcription level and might suppress lipolysis and lipid utilization to protect the liver from excess accumulation of toxic cholesterol...
  14. ncbi request reprint Dietary palatinose and oleic acid ameliorate disorders of glucose and lipid metabolism in Zucker fatty rats
    Kazusa Sato
    Department of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima 770 8503, Japan
    J Nutr 137:1908-15. 2007
    ..The combination of palatinose and oleic acid holds promise for a new approach to preventing and treating obesity and its complications...
  15. ncbi request reprint Advantage of a low glycemic index and low phosphate diet on diabetic nephropathy and aging-related diseases
    Yutaka Taketani
    Department of Clinical Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    J Med Invest 54:359-65. 2007
    ..A low glycemic index and low phosphate diet may provide an advantage in the prevention of aging-related diseases in healthy individuals as well as in those with chronic kidney disease...
  16. ncbi request reprint Role of serine 249 of ezrin in the regulation of sodium-dependent phosphate transporter NaPi-IIa activity in renal proximal tubular cells
    Fumiyo Yamada
    Department of Clinical Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    J Med Invest 60:27-34. 2013
    ..The S249D mutant also inhibited the interaction with NHERF-1. Therefore, serine 249 of ezrin can play important roles in the regulation of the complex formation and membrane localization of NaPi-IIa...
  17. ncbi request reprint Dietary quercetin inhibits bone loss without effect on the uterus in ovariectomized mice
    Mitsuyoshi Tsuji
    Department of Clinical Nutrition, Institute of Health Biosciences, The University of Tokushima, Tokushima 770 8503, Japan
    J Bone Miner Metab 27:673-81. 2009
    ..These results suggest that dietary quercetin inhibits bone loss without effect on the uterus in OVX mice and does not act as a potent inhibitor of osteoclastogenesis or as a selective estrogen receptor modulator in vivo...
  18. pmc Paradoxical regulation of human FGF21 by both fasting and feeding signals: is FGF21 a nutritional adaptation factor?
    Takashi Uebanso
    Department of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan
    PLoS ONE 6:e22976. 2011
    ..These regulatory mechanisms suggest that human FGF21 is increased with nutritional crisis, including starvation and overfeeding...
  19. doi request reprint Regulation of renal sodium-dependent phosphate co-transporter genes (Npt2a and Npt2c) by all-trans-retinoic acid and its receptors
    Masashi Masuda
    Department of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School, Kuramoto Cho, Japan
    Biochem J 429:583-92. 2010
    ..In summary, we conclude that VAD induces hyperphosphaturia through the down-regulation of Npt2a and Npt2c gene expression in the kidney...
  20. ncbi request reprint Natto and viscous vegetables in a Japanese style meal suppress postprandial glucose and insulin responses
    Akiko Taniguchi
    Department of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School, Japan
    Asia Pac J Clin Nutr 17:663-8. 2008
    ..The consumption of naturally viscous vegetables with white rice reduced acute glycemia and insulinemia. This practical dietary combination would ensure compliance and favorably alter the risk for diabetes and cardiovascular diseases...
  21. ncbi request reprint Gene expression profiling in peripheral white blood cells in response to the intake of food with different glycemic index using a DNA microarray
    Yuka Kawakami
    Department of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan
    J Nutrigenet Nutrigenomics 6:154-68. 2013
    ..We observed the time course of gene expression changes in peripheral white blood cells (WBC) to elucidate the metabolic changes in the postprandial state that are a reflection and a marker of whole body metabolic changes...
  22. doi request reprint Stanniocalcin 2 is associated with ectopic calcification in α-klotho mutant mice and inhibits hyperphosphatemia-induced calcification in aortic vascular smooth muscle cells
    Yuichiro Takei
    Department of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School, Kuramoto Cho 3, Tokushima 770 8503, Japan
    Bone 50:998-1005. 2012
    ....
  23. ncbi request reprint Effects of a palatinose-based liquid diet (Inslow) on glycemic control and the second-meal effect in healthy men
    Hidekazu Arai
    Department of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima 770 8503, Japan
    Metabolism 56:115-21. 2007
    ..05). In conclusion, consumption of Inslow at breakfast appears to improve patient glycemic control by reducing their postprandial plasma glucose and insulin levels after lunch (second-meal effect)...
  24. ncbi request reprint Restraint stress alters the duodenal expression of genes important for lipid metabolism in rat
    Tadatoshi Sato
    Department of Clinical Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School, 3 18 15, Kuramoto Cho, Tokushima 770 8503, Japan
    Toxicology 227:248-61. 2006
    ..These results suggest that immobilization may alter lipid metabolism in the small intestine by modifying the expression of specific genes through which the small intestine may seek to protect itself from stress-induced damage...
  25. doi request reprint Thyroid hormones decrease plasma 1α,25-dihydroxyvitamin D levels through transcriptional repression of the renal 25-hydroxyvitamin D3 1α-hydroxylase gene (CYP27B1)
    Mina Kozai
    Department of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School, 3 18 15 Kuramoto cho, Tokushima City, 770 8503, Japan
    Endocrinology 154:609-22. 2013
    ..These results suggest that transcriptional repression of the CYP27B1 gene by T(3)-bound TRs/RXRα, acting through the 1α-nTRE, results in decreased renal CYP27B1 expression and plasma 1,25(OH)(2)D levels...
  26. doi request reprint Thyroid hormones regulate phosphate homoeostasis through transcriptional control of the renal type IIa sodium-dependent phosphate co-transporter (Npt2a) gene
    Mariko Ishiguro
    Department of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School, Kuramoto cho 3 18 15, Tokushima City 770 8503, Japan
    Biochem J 427:161-9. 2010
    ..These results suggest that Npt2a plays a critical role as a T3-target gene, to control phosphate homoeostasis, and that T3 transcriptionally activates the Npt2a gene via TRs in a renal cell-specific manner...
  27. ncbi request reprint Comparison of measured and predicted energy expenditure in patients with liver cirrhosis
    Arisa Teramoto
    Department of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School, 3 18 15, Kuramotocho, Tokushima 770 8503, Japan
    Asia Pac J Clin Nutr 23:197-204. 2014
    ....
  28. ncbi request reprint Stanniocalcin 2 is positively and negatively controlled by 1,25(OH)(2)D(3) and PTH in renal proximal tubular cells
    Yuichiro Takei
    Department of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School, Kuramoto Cho, Tokushima City, Japan
    J Mol Endocrinol 42:261-8. 2009
    ..These results suggest that STC2 is positively and negatively controlled by 1,25(OH)(2)D(3) and PTH in renal proximal tubular cells...
  29. ncbi request reprint Hypocaloric high-protein diet improves fatty liver and hypertriglyceridemia in sucrose-fed obese rats via two pathways
    Takashi Uebanso
    Department of Clinical Nutrition, University of Tokushima Graduate School, Tokushima, Japan
    Am J Physiol Endocrinol Metab 297:E76-84. 2009
    ..The two cellular pathways at work behind these benefits include stimulation of hepatic lipolysis and lipid utilization mediated by FGF21 and reduction of hepatic VLDL-TG production by SCD1 regulation...
  30. ncbi request reprint Mechanism of rapid-phase insulin response to elevation of portal glucose concentration
    Makiko Fukaya
    Department of Clinical Nutrition, University of Tokushima School of Medicine, Tokushima, Japan
    Am J Physiol Endocrinol Metab 293:E515-22. 2007
    ....
  31. ncbi request reprint Effect of a novel palatinose-based liquid balanced formula (MHN-01) on glucose and lipid metabolism in male Sprague-Dawley rats after short- and long-term ingestion
    Hidekazu Arai
    Department of Clinical Nutrition, University of Tokushima School of Medicine, Japan
    Metabolism 53:977-83. 2004
    ..Therefore, human study on the effects of MHN-01 on carbohydrate and lipid metabolism will be recommended to confirm whether MHN-01 may be a useful functional food for the treatment and prevention of insulin resistance...
  32. ncbi request reprint Evaluation of anti-stress nutrients in the endothelial cells with fluorescence indicator
    Kunitaka Nashiki
    Department of Clinical Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School, Japan
    J Med Invest 52:295-6. 2005
    ..The combination of those fluorescence indicators could be powerful tool to evaluate the effect of anti-stress nutrients on both oxidative stress and endothelial dysfunction...
  33. doi request reprint Natto and viscous vegetables in a Japanese-style breakfast improved insulin sensitivity, lipid metabolism and oxidative stress in overweight subjects with impaired glucose tolerance
    Akiko Taniguchi-Fukatsu
    Department of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School, 3 18 15 Kuramoto, Tokushima 770 8503, Japan
    Br J Nutr 107:1184-91. 2012
    ..No differences were observed in the measures of chronic glycaemic control. Thus, we conclude that a breakfast of natto and viscous vegetables consumed for 2 weeks improves insulin sensitivity, serum lipid and oxidative stress...
  34. ncbi request reprint Extracts of Momordica charantia suppress postprandial hyperglycemia in rats
    Takashi Uebanso
    Department of Clinical Nutrition, University of Tokushima Graduate School, Tokushima, Japan
    J Nutr Sci Vitaminol (Tokyo) 53:482-8. 2007
    ..Taken together, these results demonstrated that bitter melon suppressed postprandial hyperglycemia by inhibition of alpha-glucosidase activity and that the most beneficial component is present in the LT 1,300 fraction obtained from MF...
  35. ncbi request reprint A novel function of phosphate-mediated intracellular signal transduction pathways
    Eiji Takeda
    Department of Clinical Nutrition, Institute of Health Biosciences, the University of Tokuhsima Graduate School, Tokushima 770 8503, Japan
    Adv Enzyme Regul 46:154-61. 2006
  36. ncbi request reprint Hypercholesterolemia and effects of high cholesterol diet in type IIa sodium-dependent phosphate co-transporter (Npt2a) deficient mice
    Sarasa Tanaka
    Department of Clinical Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School
    J Med Invest 60:191-6. 2013
    ..These results suggest that ablation of Npt2a gene induces hypercholesterolemia and affects the ability to respond normally to dietary cholesterol...
  37. doi request reprint Treatment of rapid weight loss in a donor with hepatic steatosis in living donor liver transplantation: a case report
    Hisami Yamanaka-Okumura
    Department of Clinical Nutrition, University of Tokushina Graduate School, Tokushima, Japan
    Hepatogastroenterology 59:869-71. 2012
    ..Therefore, energy metabolism and NEFA levels represent important biomarkers for short-term intensive treatment by restricted diet and exercise in donors with hepatic steatosis...
  38. ncbi request reprint Nutritional treatment of a patient with hepatic cirrhosis with the novel low glycemic index liquid food (Inslow)
    Dai Matsumoto
    Department of Clinical Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    J Med Invest 54:375-80. 2007
    ..This indicates a marked improvement in insulin sensitivity due to Inslow administration in this patient. In conclusion, the long-term administration of Inslow as an LES may be an effective treatment for cirrhotic patients...
  39. pmc The Anti-Obesity Effect of the Palatinose-Based Formula Inslow is Likely due to an Increase in the Hepatic PPAR-alpha and Adipocyte PPAR-gamma Gene Expressions
    Kaoru Matsuo
    Department of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School, 3 18 15 Kuramoto, Tokushima 770 8503, Japan
    J Clin Biochem Nutr 40:234-41. 2007
    ..These results strongly suggested that the anti-obesity effect of Inslow was due to an increase in the hepatic PPAR-alpha and adipocyte PPAR-gamma gene expressions...
  40. ncbi request reprint Immobilization decreases duodenal calcium absorption through a 1,25-dihydroxyvitamin D-dependent pathway
    Tadatoshi Sato
    Department of Clinical Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School, 3 18 15 Kuramoto cho, Tokushima, 770 8503, Japan
    J Bone Miner Metab 24:291-9. 2006
    ..However, it remains unclear that calcium absorption and expression of calcium transport proteins are essential for the regulation of lumbar BMD...
  41. ncbi request reprint Alternative promoters and renal cell-specific regulation of the mouse type IIa sodium-dependent phosphate cotransporter gene
    Hironori Yamamoto
    Department of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School, Kuramoto cho 3 18 15, Tokushima City 770 8503, Japan
    Biochim Biophys Acta 1732:43-52. 2005
    ..These data suggested that two alternative promoters control the renal expression of Npt2a gene and both Npt2a variant transcripts are down regulated in Hyp mice...
  42. ncbi request reprint Protective effects of glycoglycerolipids extracted from spinach on 5-fluorouracil induced intestinal mucosal injury
    Asuka Shiota
    Department of Clinical Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    J Med Invest 57:314-20. 2010
    ..We concluded that glycolipid extracts from spinach has anti-oxidative and anti-inflammatory effects, and the extract may be useful for prevention of drug-induced mucosal injury and other inflammatory diseases. Tokushima..
  43. ncbi request reprint Role of membrane microdomains in PTH-mediated down-regulation of NaPi-IIa in opossum kidney cells
    Kunitaka Nashiki
    Department of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan
    Kidney Int 68:1137-47. 2005
    ..Since the relationship between PTH signaling and NaPi-IIa endocytosis has not been explored, we investigated the role of membrane microdomains in this process...
  44. pmc Up-regulation of stanniocalcin 1 expression by 1,25-dihydroxy vitamin D(3) and parathyroid hormone in renal proximal tubular cells
    Nguyen Trong Hung
    Department of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School, Kuramoto cho 3 18 15, Tokushima 770 8503, Japan
    J Clin Biochem Nutr 50:227-33. 2012
    ..These results suggest that the stanniocalcin 1 gene expression is up-regulated by 1,25(OH)(2)D(3) and parathyroid hormone through mRNA stabilization in renal proximal tubular cells...
  45. pmc Effects of xylitol on metabolic parameters and visceral fat accumulation
    Kikuko Amo
    Department of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima 770 8503, Japan
    J Clin Biochem Nutr 49:1-7. 2011
    ..In conclusion, intake of xylitol may be beneficial in preventing the development of obesity and metabolic abnormalities in rats with diet-induced obesity...
  46. ncbi request reprint [Vitamin D and phosphate metabolism; relationship with aging-regulating gene]
    Yutaka Taketani
    University of Tokushima Graduate School, Institute of Health Biosciences, Department of Clinical Nutrition
    Clin Calcium 16:1137-42. 2006
    ..Regulation of vitamin D and phosphate metabolism is closely related to aging processes as well as bone and mineral metabolism...
  47. ncbi request reprint Caveolin-1 in extracellular matrix vesicles secreted from osteoblasts
    Naoki Sawada
    Department of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School, 3 18 15 Kuramoto cho, Tokushima 770 8503, Japan
    Bone 41:52-8. 2007
    ..These results suggest that secreted caveolin-1 as a component of matrix vesicles may play an important role in osteoblast calcification...
  48. ncbi request reprint Water extract of Cordyceps sinensis (WECS) inhibits the RANKL-induced osteoclast differentiation
    Yoko Mizuha
    Department of Clinical Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School, Kuramoto Cho, Tokushima, Japan
    Biofactors 30:105-16. 2007
    ..In conclusion, the present results demonstrate for the first time that WECS is a potent inhibitor of the RANKL-induced osteoclast differentiation through a mechanism involving the NF-kappaB pathway...
  49. ncbi request reprint Early-phase insulin secretion is disturbed in obese subjects with glucose intolerance
    Akira Mizuno
    Department of Clinical Biology and Medicine, Institute of Health Bioscience, University of Tokushima, Graduate School, Tokushima 770 8503, Japan
    Metabolism 56:856-62. 2007
    ..The early-phase insulin secretion is well maintained in O-NGT; however, early-phase insulin secretion has already been disturbed in obese subjects with glucose intolerance...
  50. pmc Effects of prolonged high phosphorus diet on phosphorus and calcium balance in rats
    Yoshiko Tani
    Department of Clinical Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770 8503, Japan
    J Clin Biochem Nutr 40:221-8. 2007
    ..Taken together, these results suggest that diets containing 1.2 or 1.5% phosphorus plus 0.6% calcium have potentially adverse effects on phosphorus homeostasis in mature rat...
  51. ncbi request reprint Increase in IP3 and intracellular Ca2+ induced by phosphate depletion in LLC-PK 1 cells
    Yutaka Taketani
    Department of Clinical Nutrition, School of Medicine, University of Tokushima, 770 8503, Tokushima, Japan
    Biochem Biophys Res Commun 305:287-91. 2003
    ..These results suggest that Pi depletion causes IP(3)-mediated release of Ca(2+) from intracellular Ca(2+) pools and rapidly increases [Ca(2+)](i) in LLC-PK(1) cells...
  52. doi request reprint Recovery pattern of non-protein respiratory quotient and non-esterified fatty acids after liver resection
    Kohei Sugihara
    Departments of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan
    Nutrition 30:443-8. 2014
    ....
  53. doi request reprint Age-related variations of appetite sensations of fullness and satisfaction with different dietary energy densities in a large, free-living sample of Japanese adults
    Bei Zhou
    Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan
    J Acad Nutr Diet 113:1155-64. 2013
    ..The effective energy density (ED) diet model for customized meal plans has not been adequately explored, and the specific differences in appetite sensation among age groups remain unclear...
  54. ncbi request reprint Flavonoids as substrates and inhibitors of myeloperoxidase: molecular actions of aglycone and metabolites
    Yuko Shiba
    Department of Food Science, Graduate School of Nutrition and Biosciences, The University of Tokushima, Tokushima 770 8503, Japan
    Chem Res Toxicol 21:1600-9. 2008
    ..The current study provides the structure-activity relationships for flavonoids as the anti-inflammatory dietary constituents targeting the MPO-derived oxidative reactions in vivo...
  55. ncbi request reprint Insulin resistance as early sign of hepatic dysfunction in liver cirrhosis
    Kayo Taguchi
    Department of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School
    J Med Invest 61:180-9. 2014
    ..Insulin resistance in both liver and peripheral tissues is the early sign in the patients with LC. This fact indicates that nutritional care from early stages of LC would be necessary in the patients...
  56. ncbi request reprint Analysis of different complexes of type IIa sodium-dependent phosphate transporter in rat renal cortex using blue-native polyacrylamide gel electrophoresis
    Ayako Tanimura
    Department of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan
    J Med Invest 58:140-7. 2011
    ..These results suggest that NaPi-IIa can form some different complexes on the apical plasma membrane of renal proximal tubular cells...
  57. pmc Dietary phosphate restriction ameliorates endothelial dysfunction in adenine-induced kidney disease rats
    Tan Vu Van
    Department of Clinical Nutrition, University of Tokushima Graduate School, 3 18 15, Kuramoto Cho, Tokushima 770 8503, Japan
    J Clin Biochem Nutr 51:27-32. 2012
    ..Thus, dietary phosphate restriction can improve aortic endothelial dysfunction in chronic kidney disease with hyperphosphatemia by increase in the activatory phosphorylations of endothelial nitric oxide synthase and Akt...
  58. pmc High phosphate diet reduces atherosclerosis formation in apolipoprotein E-deficient mice
    Asuka Shiota
    Department of Clinical Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School, 3 18 15 Kuramoto cho, Tokushima 770 8503, Japan
    J Clin Biochem Nutr 49:109-14. 2011
    ..These observations suggest that excess phosphate intake decreased atherosclerosis formation, at least in part, by changing the profile of peripheral monocytes or inducing apoptosis of macrophages in apolipoprotein E-deficient mice...
  59. pmc Dose-dependent effects of barley cooked with white rice on postprandial glucose and desacyl ghrelin levels
    Masae Sakuma
    Department of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School, 3 18 15 Kuramoto, Tokushima 770 8503, Japan
    J Clin Biochem Nutr 44:151-9. 2009
    ..The combination of white rice with barley plays a beneficial role in preventing and treating type 2 diabetes, obesity and other metabolic diseases...
  60. pmc Fermented ginseng improves the first-night effect in humans
    Kazuyoshi Kitaoka
    Department of Integrative Physiology, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan
    Sleep 32:413-21. 2009
    ..The goal of this study was to clarify whether ginseng fermented by lactic acid bacteria (fermented ginseng, FG), can improve the first-night effect (FNE) in humans...
  61. ncbi request reprint Effect of long-term late-evening snack on health-related quality of life in cirrhotic patients
    Hisami Yamanaka-Okumura
    Department of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Tokushima, Japan
    Hepatol Res 40:470-6. 2010
    ..Conclusion: Long-term LES administration may be helpful in maintaining higher HRQOL in patients with cirrhosis...
  62. ncbi request reprint Mutation in saposin D domain of sphingolipid activator protein gene causes urinary system defects and cerebellar Purkinje cell degeneration with accumulation of hydroxy fatty acid-containing ceramide in mouse
    Junko Matsuda
    Department of Pediatrics, The Institute of Health Bioscience, The University of Tokushima Graduate School, 3 18 15, Kuramoto Cho, Tokushima 770 8503, Japan
    Hum Mol Genet 13:2709-23. 2004
    ..These results not only indicate the role of saposin D in in vivo ceramide metabolism, but also suggest possible cytotoxicity of ceramide underlying the cerebellar Purkinje cell and renal tubular cell degeneration...
  63. ncbi request reprint Immunohistochemical and RT-PCR detection of Na+-dependent inorganic phosphate cotransporter (NaPi-2) in rat brain
    S Hisano
    Department of Anatomy, School of Medicine, University of Tokushima, Japan
    Brain Res 772:149-55. 1997
    ..The present results suggest that NaPi-2 is synthesized within the brain and involved in maintaining Pi homeostasis of certain neurons and/or the entire brain...
  64. ncbi request reprint Acute regulation by dietary phosphate of the sodium-dependent phosphate transporter (NaP(i)-2) in rat kidney
    K Katai
    Department of Clinical Nutrition, School of Medicine, Tokushima University
    J Biochem 121:50-5. 1997
    ..These results suggested that rapid endocytotic internalization of NaP(i)-2 may occur specifically in the brush border membrane following an acute increase in dietary P(i) intake...
  65. ncbi request reprint Molecular cloning and hormonal regulation of PiT-1, a sodium-dependent phosphate cotransporter from rat parathyroid glands
    S Tatsumi
    Department of Clinical Nutrition, School of Medicine, Tokushima University, Tokushima City, Japan
    Endocrinology 139:1692-9. 1998
    ..Furthermore, the abundance of PiT-1 mRNA in the parathyroid was much greater in rats fed a low-Pi diet than in those fed a high-Pi diet. Thus, rat PiT-1 may contribute to the effects of Pi and vitamin D on parathyroid function...
  66. pmc Cloning and functional expression of a Na(+)-dependent phosphate co-transporter from human kidney: cDNA cloning and functional expression
    K Miyamoto
    Department of Clinical Nutrition, School of Medicine, University of Tokushima, Japan
    Biochem J 305:81-5. 1995
    ..These findings indicate that two high-affinity Na/P(i) cotransporters (NaP(i)-3 and NPT-1) are present in human kidney cortex...
  67. pmc Regulation of intestinal Na+-dependent phosphate co-transporters by a low-phosphate diet and 1,25-dihydroxyvitamin D3
    K Katai
    Department of Clinical Nutrition, School of Medicine, Tokushima University, Kuramoto Cho 3, Tokushima City, Tokushima 770, Japan
    Biochem J 343:705-12. 1999
    ..PiUS and PiT-2 might be important components in the regulation of the intestinal P(i) transport system by P(i) restriction and 1,25-(OH)(2)D(3)...
  68. ncbi request reprint Effect of late evening snack with rice ball on energy metabolism in liver cirrhosis
    H Yamanaka-Okumura
    Department of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan
    Eur J Clin Nutr 60:1067-72. 2006
    ..Impaired nutritional metabolism has been associated with cirrhosis, and frequent intake of small meals may prevent early-onset starvation, and maintain nourishment in these patients...
  69. ncbi request reprint Close correlation between estrogen treatment and renal phosphate reabsorption capacity
    H Uemura
    Department of Obstetrics and Gynecology, The University of Tokushima, School of Medicine, Japan
    J Clin Endocrinol Metab 85:1215-9. 2000
    ..These results suggest that estrogen could act directly to suppress sodium-dependent Pi reabsorption in the renal proximal tubules...
  70. ncbi request reprint What influences appetite more: eating approaches or cooking methods?
    Bei Zhou
    Department of Clinical Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School
    J Med Invest 61:118-25. 2014
    ..Taken together, these findings suggest that cooking methods should be altered for different situations with an adequate amount of vegetables, and the meal duration should be recommended to be given as much attention as cooking methods...
  71. pmc Increasing dietary phosphorus intake from food additives: potential for negative impact on bone health
    Eiji Takeda
    Department of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima City, Tokushima, Japan
    Adv Nutr 5:92-7. 2014
    ..These findings suggest that long-term high-phosphorus diets may impair bone health mediated by FGF23 resistance both in chronic kidney disease patients and in the healthy population. ..
  72. ncbi request reprint [Lack of phosphorus intake and nutrition]
    Eiji Takeda
    Department of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School, Japan
    Clin Calcium 22:1487-91. 2012
    ..This is potentially fatal, yet is preventable. Awareness and identification of at-risk patients is crucial to improving management...
  73. doi request reprint [Calcium pros and cons significance and risk of phosphorus supplementation. The necessity of phosphorus supplementation for hypophosphatemia]
    Eiji Takeda
    Institute of Health Biosciences, University of Tokushima Graduate School, Japan
    Clin Calcium 21:167-70. 2011
    ..In clinical practice it is common on administering 0.4 mmol (12 mg) phosphate/kg per day, and to adjust this on the basis of the serum phosphate analysis...
  74. ncbi request reprint Effects of lifestyle habits and eating meals together with the family on the prevalence of obesity among school children in Tokushima, Japan: a cross-sectional questionnaire-based survey
    Kyoko Yuasa
    Department of Human Genetics and Public Health, The University of Tokushima Graduate School, Tokushima, Japan
    J Med Invest 55:71-7. 2008
    ..We recommend that parents and school teaching staff encourage the establishment of sound, healthy lifestyle habits in children from early childhood as an effective measure for the prevention of obesity...
  75. ncbi request reprint [The optimum amount of vitamin D for osteoporosis: in case of activated vitamin D treatment]
    Hironori Yamamoto
    Department of Clinical Nutrition, School of Medicine, Tokushima University, Japan
    Clin Calcium 14:56-9. 2004
    ..Therefore, the action as a medicine is not simple. This article reviews the effect and its optimum ingestion amount of activated vitamin D in osteoporosis medical treatment...
  76. ncbi request reprint [Phosphorus intake and bone mineral density (BMD)]
    Akihiko Kawaura
    Department of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School
    Clin Calcium 15:1501-6. 2005
    ..74 of Ca/P were associated with better bone mineral density (BMD) values in young women. However, there are few reports of correlations between appropriate phosphorus intake, Ca/P rate and BMD...
  77. doi request reprint Diurnal amplitudes of arterial pressure and heart rate are dampened in Clock mutant mice and adrenalectomized mice
    Hiroyoshi Sei
    Department of Integrative Physiology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    Endocrinology 149:3576-80. 2008
    ..Our data suggest that the adrenal gland is involved in the diurnal amplitude, but not the acrophase, of AP and HR, and that the function of the Clock gene may be related to the nondipping type of AP elevation...
  78. ncbi request reprint Human nutritional science on stress control
    Eiji Takeda
    The 21st Century COE Program Human nutritional science on stress control, Institute of Health Biosciences, The University of Tokushima Graduate School, Japan
    J Med Invest 52:223-4. 2005
    ..This exciting science has been vigorously achieving in the 21st century COE program of University of Tokushima Graduate School...
  79. ncbi request reprint Impact of splenectomy in patients with liver cirrhosis: Results from 18 patients in a single center experience
    Satoru Imura
    Departments of Surgery, Institute of Health Biosciences, University of Tokushima, Tokushima, Japan
    Hepatol Res 40:894-900. 2010
    ..Conclusion:  Splenectomy improved hepatic functional reserve and nutritional metabolism in some cases. However, the long-term outcomes should still be evaluated...
  80. pmc Gene structure and functional analysis of the human Na+/phosphate co-transporter
    Y Taketani
    Department of Clinical Nutrition, School of Medicine, University of Tokushima, Kuramoto Cho 3, Tokushima 770, Japan
    Biochem J 324:927-34. 1997
    ..The presence of the three vitamin D receptor- responsive elements in the NaPi-3 promoter may be important in mediating the enhanced expression of the gene by 1,25-dihydroxyvitamin D3...
  81. ncbi request reprint Identification of regulatory sequences and binding proteins in the type II sodium/phosphate cotransporter NPT2 gene responsive to dietary phosphate
    S Kido
    Department of Clinical Nutrition, School of Medicine, Tokushima University, Kuramoto Cho 3, Tokushima City 770, Japan
    J Biol Chem 274:28256-63. 1999
    ..The feeding of a low P(i) diet significantly increased the amount of TFE3 mRNA in the kidney. These findings suggest that TFE3 may participate in the transcriptional regulation of the NPT2 gene by dietary P(i)...
  82. pmc Molecular events involved in up-regulating human Na+-independent neutral amino acid transporter LAT1 during T-cell activation
    T Nii
    Department of Clinical Nutrition, School of Medicine, Tokushima University, Kuramoto Cho 3, Tokushima City 770 8503, Japan
    Biochem J 358:693-704. 2001
    ..These findings indicated that a removal of the block to mRNA elongation stimulates the induction of system-L amino acid transporter gene transcripts (LAT1 and 4F2hc) in activated T-cells...
  83. ncbi request reprint Identification of three isoforms for the Na+-dependent phosphate cotransporter (NaPi-2) in rat kidney
    S Tatsumi
    Department of Clinical Nutrition, School of Medicine, Tokushima University, Tokushima 770, Japan
    J Biol Chem 273:28568-75. 1998
    ..The results suggest that these short isoforms may function as a dominant negative inhibitor of the full-length transporter...
  84. ncbi request reprint Sequence, tissue distribution and developmental changes in rat intestinal oligopeptide transporter
    K Miyamoto
    Department of Clinical Nutrition, School of Medicine, Tokushima University, Japan
    Biochim Biophys Acta 1305:34-8. 1996
    ..Intestinal PepT1 mRNA levels were highest in 4-day old rats, and then decreased reaching the adult level by day 28 after birth. These results indicate that the expressions of PepT1 gene change markedly during development...
  85. ncbi request reprint Characterization of the 5' flanking region of the human NPT-1 Na+/phosphate cotransporter gene
    Y Taketani
    Department of Clinical Nutrition, School of Medicine, University of Tokushima, Japan
    Biochim Biophys Acta 1396:267-72. 1998
    ..Transient expression revealed that a 45-bp region of proximal to exon 1, which contained TATA-like sequence, was sufficient for promoting luciferase expression in OK-cells derived from opossum kidney proximal tubule...
  86. ncbi request reprint Stress control and human nutrition
    Eiji Takeda
    Department of Clinical Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    J Med Invest 51:139-45. 2004
    ..Therefore, it is concluded that the establishment of functional foods that correctly regulate stress response must be firmly based upon scientific knowledge and legal regulation...
  87. ncbi request reprint Effects of truncation of the COOH-terminal region of a Na+-independent neutral and basic amino acid transporter on amino acid transport in Xenopus oocytes
    K Miyamoto
    Department of Clinical Nutrition, School of Medicine, Tokushima University, Kuramoto Cho 3, Tokushima 770, Japan
    J Biol Chem 271:16758-63. 1996
    ..These results suggest that NBAT functions as a activator of the amino acid transport system in Xenopus oocytes...
  88. ncbi request reprint Acute effect of oral phosphate loading on serum fibroblast growth factor 23 levels in healthy men
    Y Nishida
    Department of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan
    Kidney Int 70:2141-7. 2006
    ..We conclude that oral Pi loading cannot rapidly increase serum FGF23 level. FGF23 may be not associated with rapid adaptation of Pi homeostasis...
  89. pmc Cloning, functional expression and dietary regulation of the mouse neutral and basic amino acid transporter (NBAT)
    H Segawa
    Department of Clinical Nutrition, School of Medicine, Tokushima University, Kuramoto Cho 3, Tokushima 770, Japan
    Biochem J 328:657-64. 1997
    ..These results demonstrate that mouse NBAT has an important role in cystine transport...
  90. ncbi request reprint Structural organization of the human vitamin D receptor chromosomal gene and its promoter
    K Miyamoto
    Department of Clinical Nutrition, Tokushima University, Japan
    Mol Endocrinol 11:1165-79. 1997
    ..The recovery of the gene for the human VDR will enable further studies on the transcriptional regulation of this gene...
  91. ncbi request reprint The polymorphism in the caudal-related homeodomain protein Cdx-2 binding element in the human vitamin D receptor gene
    H Arai
    Department of Clinical Nutrition, School of Medicine, University of Tokushima, Japan
    J Bone Miner Res 16:1256-64. 2001
    ..Thus, the polymorphism in the Cdx-2 binding site of the VDR gene (Cdx-polymorphism) would affect the expression of VDR in the small intestine. In addition, this polymorphism may modulate BMD in postmenopausal Japanese women...
  92. ncbi request reprint Mutation of E1 alpha gene in a female patient with pyruvate dehydrogenase deficiency due to rapid degradation of E1 protein
    M Ito
    Department of Pediatrics School of Medicine, University of Tokushima, Japan
    J Inherit Metab Dis 15:848-56. 1992
    ..The mutant alpha subunit protein failed to form a stable structure of pyruvate dehydrogenase, so that both alpha and beta subunit proteins were degraded rapidly...
  93. ncbi request reprint 1 alpha,25-Dihydroxyvitamin D(3) is a preventive factor in the metastasis of lung cancer
    Kimie Nakagawa
    Department of Hygienic Sciences, Kobe Pharmaceutical University, 4 19 1 Motoyamakita machi, Higashinada ku, Kobe 658 8558, Japan
    Carcinogenesis 26:429-40. 2005
    ..Here we show that 1alpha,25(OH)(2)D(3) inhibits the metastatic growth of lung cancer cells in a defined animal model...
  94. ncbi request reprint Estimation of total daily energy expenditure and its components by monitoring the heart rate of Japanese endurance athletes
    Keiko Motonaga
    Department of Care Work, Faculty of Social Welfire, Kinki Welfare University, 1966 5, Takaoka Fukusaki, Kanzaki, Hyogo 679 2217, Japan
    J Nutr Sci Vitaminol (Tokyo) 52:360-7. 2006
    ..The TEE of the endurance athletes was higher than expected and significantly affected by exercise EE, indicating that the TEE of athletes, in general, must be carefully evaluated before incorporating nutritional support for them...
  95. ncbi request reprint Metastatic growth of lung cancer cells is extremely reduced in Vitamin D receptor knockout mice
    Kimie Nakagawa
    Department of Hygienic Sciences, Kobe Pharmaceutical University, 4 19 1 Motoyamakita machi, Higashinada ku, Kobe 658 8558, Japan
    J Steroid Biochem Mol Biol 89:545-7. 2004
    ..These findings establish a critical role for 1alpha,25(OH)(2)D(3) in lung metastatic neoplasms and provide a new model for metastasis of malignant cells...
  96. ncbi request reprint Higher concentrations of interferon-gamma enhances uptake and transport of dietary antigens by human intestinal cells: a study using cultured Caco-2 cells
    Tomoko Koda
    Department of Nutrition, Faculty of Human Life Sciences, Yamaguchi Prefectural University, 3 2 1 Sakurabatake, Yamaguchi 753 8502, Japan
    J Nutr Sci Vitaminol (Tokyo) 49:179-86. 2003
    ..Therefore, higher concentrations of IFN-gamma stimulate the uptake, processing, and transport of dietary antigens by IECs...
  97. ncbi request reprint Combination treatment with 1alpha,25-dihydroxyvitamin D3 and 9-cis-retinoic acid directly inhibits human telomerase reverse transcriptase transcription in prostate cancer cells
    Naoya Ikeda
    Department of Urology, Graduate School of Medicine, Yokohama City University, Kanagawa 236 0004, Japan
    Mol Cancer Ther 2:739-46. 2003
    ..The results of the present study provide evidence on the molecular mechanism of the inhibition of cell growth by these agents, and they could be novel therapeutic agents for prostate cancer...
  98. ncbi request reprint Hydrogen peroxide stimulates c-Src-mediated big mitogen-activated protein kinase 1 (BMK1) and the MEF2C signaling pathway in PC12 cells: potential role in cell survival following oxidative insults
    Yuki Suzaki
    Department of Pharmacology, Pediatrics, Virology, and Clinical Nutrition, The University of Tokushima School of Medicine, Tokushima 770 8503, Japan
    J Biol Chem 277:9614-21. 2002
    ..These findings suggest that c-Src mediated BMK1 activation by H(2)O(2) may counteract ischemic cellular damage probably through the activation of MEF2C transcription factor...