A Takahashi

Summary

Affiliation: The University of Tokushima
Country: Japan

Publications

  1. pmc Hfq regulates the expression of the thermostable direct hemolysin gene in Vibrio parahaemolyticus
    Masayuki Nakano
    Department of Nutrition and Metabolism, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    BMC Microbiol 8:155. 2008
  2. ncbi request reprint Production of beta-defensin-2 by human colonic epithelial cells induced by Salmonella enteritidis flagella filament structural protein
    A Takahashi
    Department of Nutrition, School of Medicine, University of Tokushima, Japan
    FEBS Lett 508:484-8. 2001
  3. ncbi request reprint Aeromonas sobria hemolysin causes diarrhea by increasing secretion of HCO3-
    Akira Takahashi
    Department of Nutrition and Metabolism, The University of Tokushima Graduate School, Institute of Health Biosciences, Tokushima City, Tokushima, Japan
    FEMS Microbiol Lett 258:92-5. 2006
  4. ncbi request reprint A pore-forming toxin produced by Aeromonas sobria activates Ca2+ dependent Cl- secretion
    Akira Takahashi
    Department of Nutrition and Metabolism, Institute of Health Biosciences, The University of Tokushima Graduate School, 3 18 5 Kuramoto cho, Tokushima City, Tokushima 770 8503, Japan
    Microb Pathog 38:173-80. 2005
  5. ncbi request reprint Chloride secretion induced by thermostable direct haemolysin of Vibrio parahaemolyticus depends on colonic cell maturation
    A Takahashi
    Department of Bacterial Infections, Research Institute for Microbial Diseases, Osaka University, Suita, Japan
    J Med Microbiol 50:870-8. 2001
  6. ncbi request reprint Mechanisms of chloride secretion induced by thermostable direct haemolysin of Vibrio parahaemolyticus in human colonic tissue and a human intestinal epithelial cell line
    A Takahashi
    Department of Bacterial Infections, Research Institute for Microbial Diseases, Osaka University, Japan
    J Med Microbiol 49:801-10. 2000
  7. ncbi request reprint Haemolysin produced by Vibrio mimicus activates two Cl- secretory pathways in cultured intestinal-like Caco-2 cells
    Akira Takahashi
    Department of Nutrition, School of Medicine, Tokushima University, 3 18 5 Kuramoto cho, Tokushima City, Tokushima 770 8503, Japan
    Cell Microbiol 9:583-95. 2007
  8. ncbi request reprint Pore formation of thermostable direct hemolysin secreted from Vibrio parahaemolyticus in lipid bilayers
    Akira Takahashi
    Department of Nutrition and Metabolism, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Tokushima, Japan
    Int J Toxicol 25:409-18. 2006
  9. ncbi request reprint Direct regulation of acetylcholine release by N-methyl-D-aspartic acid receptors in rat striatum
    Y Ikarashi
    Department of Neuropsychopharmacology Tsumura, Gunma University, School of Medicine, 3 39 22 Showa machi, Maebashi, Gunma 371 8511, Japan
    Brain Res 795:215-20. 1998
  10. ncbi request reprint Differential effects of etomidate and midazolam on vascular adenosine triphosphate-sensitive potassium channels: isometric tension and patch clamp studies
    Akiyo Nakamura
    Department of Anesthesiology, University of Tokushima Graduate School, Tokushima, Japan
    Anesthesiology 106:515-22. 2007

Collaborators

Detail Information

Publications83

  1. pmc Hfq regulates the expression of the thermostable direct hemolysin gene in Vibrio parahaemolyticus
    Masayuki Nakano
    Department of Nutrition and Metabolism, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    BMC Microbiol 8:155. 2008
    ..parahaemolyticus, using an hfq deletion mutant...
  2. ncbi request reprint Production of beta-defensin-2 by human colonic epithelial cells induced by Salmonella enteritidis flagella filament structural protein
    A Takahashi
    Department of Nutrition, School of Medicine, University of Tokushima, Japan
    FEBS Lett 508:484-8. 2001
    ..We conclude that FliC increased [Ca(2+)](in) via inositol 1,4,5-trisphosphate, which was followed by up-regulating hBD-2 mRNA expression via an NF-kappaB-dependent pathway...
  3. ncbi request reprint Aeromonas sobria hemolysin causes diarrhea by increasing secretion of HCO3-
    Akira Takahashi
    Department of Nutrition and Metabolism, The University of Tokushima Graduate School, Institute of Health Biosciences, Tokushima City, Tokushima, Japan
    FEMS Microbiol Lett 258:92-5. 2006
    ..Iliac fluid accumulation was also inhibited by carbonic anhydrase inhibitors. The results suggest that ASH activates HCO3- secretion, whose level correlates with the severity of diarrhea...
  4. ncbi request reprint A pore-forming toxin produced by Aeromonas sobria activates Ca2+ dependent Cl- secretion
    Akira Takahashi
    Department of Nutrition and Metabolism, Institute of Health Biosciences, The University of Tokushima Graduate School, 3 18 5 Kuramoto cho, Tokushima City, Tokushima 770 8503, Japan
    Microb Pathog 38:173-80. 2005
    ..Peak 2 but not peak 1 was related to Cl- secretion. These results indicate that ASH activates Ca2+-dependent Cl- secretion...
  5. ncbi request reprint Chloride secretion induced by thermostable direct haemolysin of Vibrio parahaemolyticus depends on colonic cell maturation
    A Takahashi
    Department of Bacterial Infections, Research Institute for Microbial Diseases, Osaka University, Suita, Japan
    J Med Microbiol 50:870-8. 2001
    ..These results suggest that sensitivity to TDH is affected by the stage of cellular differentiation of cultured intestinal epithelial cells...
  6. ncbi request reprint Mechanisms of chloride secretion induced by thermostable direct haemolysin of Vibrio parahaemolyticus in human colonic tissue and a human intestinal epithelial cell line
    A Takahashi
    Department of Bacterial Infections, Research Institute for Microbial Diseases, Osaka University, Japan
    J Med Microbiol 49:801-10. 2000
    ..Thus, TDH increases Cl- secretion in human colonic epithelial cells, apparently through mechanisms involving cell binding and Ca2+ influx, followed by elevation of [Ca2+]in associated with PKC phosphorylation...
  7. ncbi request reprint Haemolysin produced by Vibrio mimicus activates two Cl- secretory pathways in cultured intestinal-like Caco-2 cells
    Akira Takahashi
    Department of Nutrition, School of Medicine, Tokushima University, 3 18 5 Kuramoto cho, Tokushima City, Tokushima 770 8503, Japan
    Cell Microbiol 9:583-95. 2007
    ..Thus, Ca2+-dependent and cAMP-dependent Cl- secretion may be important therapeutic targets with regard to the diarrhoea that is induced by Vibrio mimicus...
  8. ncbi request reprint Pore formation of thermostable direct hemolysin secreted from Vibrio parahaemolyticus in lipid bilayers
    Akira Takahashi
    Department of Nutrition and Metabolism, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Tokushima, Japan
    Int J Toxicol 25:409-18. 2006
    ..The authors propose that the single glycine at position 62, substituted with serine in the R7 mutant toxin, plays an important role in TDH insertion into the lipid bilayer...
  9. ncbi request reprint Direct regulation of acetylcholine release by N-methyl-D-aspartic acid receptors in rat striatum
    Y Ikarashi
    Department of Neuropsychopharmacology Tsumura, Gunma University, School of Medicine, 3 39 22 Showa machi, Maebashi, Gunma 371 8511, Japan
    Brain Res 795:215-20. 1998
    ..Taken together, the present results strongly suggest that a population of NMDA receptors exists on cholinergic interneurons within the striatum, and it directly regulates ACh release...
  10. ncbi request reprint Differential effects of etomidate and midazolam on vascular adenosine triphosphate-sensitive potassium channels: isometric tension and patch clamp studies
    Akiyo Nakamura
    Department of Anesthesiology, University of Tokushima Graduate School, Tokushima, Japan
    Anesthesiology 106:515-22. 2007
    ..The aim of this study was to investigate the effects of two imidazoline-derived intravenous anesthetics, etomidate and midazolam, on vascular adenosine triphosphate-sensitive potassium (KATP) channel activity...
  11. ncbi request reprint Effects of prostaglandin E1 on vascular ATP-sensitive potassium channels
    Satoru Eguchi
    Department of Dental Anesthesiology, Tokushima University School of Dentistry, Tokushima, Japan
    J Cardiovasc Pharmacol 50:686-91. 2007
    ..Prostaglandin E1 (PGE1) has been reported to activate ATP-sensitive potassium (KATP) channels, which induces vasorelaxation. However, direct evidence of PGE1 interactions with vascular KATP channels is limited...
  12. pmc Interaction of enteropathogenic or enterohemorrhagic Escherichia coli with HeLa cells results in translocation of cortactin to the bacterial adherence site
    V V Cantarelli
    Department of Bacterial Infections, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
    Infect Immun 68:382-6. 2000
    ..Tyrosine phosphorylation of cortactin is not induced following HeLa cell infection with EHEC or EPEC, contrary to what has been reported to occur with Shigella flexneri...
  13. ncbi request reprint Monodansylcadaverine inhibits cytotoxicity of Vibrio parahaemolyticus thermostable direct hemolysin on cultured rat embryonic fibroblast cells
    R Naim
    Department of Bacterial Infection, Research Institute for Microbial Diseases, Osaka University, Suita, Japan
    FEMS Microbiol Lett 196:99-105. 2001
    ..On the hemolytic activity of TDH, monodansylcadaverine and EGTA had no effect. These results suggest that the mechanism of cytotoxicity of TDH on Rat-1 cells was different from that of hemolytic activity of TDH on red blood cells...
  14. ncbi request reprint Effect of human airway trypsin-like protease on intracellular free Ca2+ concentration in human bronchial epithelial cells
    Mari Miki
    Department of Internal Medicine and Molecular Therapeutics, The University of Tokushima School of Medicine, Tokushima, Japan
    J Med Invest 50:95-107. 2003
    ..The Ca2+ response to HAT was desensitized by exposure of HBEC to PAR-2 AP. These results indicate that HBEC have a functional PAR-2, and HAT regulates cellular functions of HBEC via activation of PAR-2...
  15. ncbi request reprint Effects of intracellular MgADP and acidification on the inhibition of cardiac sarcolemmal ATP-sensitive potassium channels by propofol
    Hirohide Yamada
    Department of Anesthesiology, Tokushima University School of Medicine, 3 18 15 Kuramoto, Tokushima, 770 8503, Japan
    J Anesth 21:472-9. 2007
    ..The aim of this study was to investigate the effects of intracellular MgADP and acidification on K(ATP) channel inhibition by propofol...
  16. ncbi request reprint NO-1886, a lipoprotein lipase activator, attenuates vascular smooth muscle contraction in rat aorta
    Aki Nakamura
    Department of Nutrition and Metabolism, Institute of Health Biosciences, The University of Tokushima Graduate School, 3 18 15, Kuramoto Cho, Tokushima City, 770 8503, Japan
    Eur J Pharmacol 554:183-90. 2007
    ..Taken together these results demonstrate that NO-1886 attenuates smooth muscle contraction and causes vasorelaxation by an extracellular Ca(2+)- and MLCK-dependent mechanism...
  17. ncbi request reprint Molecular mechanisms of the inhibitory effects of propofol and thiamylal on sarcolemmal adenosine triphosphate-sensitive potassium channels
    Takashi Kawano
    Department of Anesthesiology, Tokushima University School of Medicine, 3 18 15 Kuramoto, Tokushima 770 8503, Japan
    Anesthesiology 100:338-46. 2004
    ..1 or Kir6.2) genes and sulfonylurea receptor (SUR1, SUR2A, or SUR2B) genes...
  18. doi request reprint Cortactin, an actin binding protein, regulates GLUT4 translocation via actin filament remodeling
    H Nazari
    Department of Nutrition and Metabolism, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan
    Biochemistry (Mosc) 76:1262-9. 2011
    ....
  19. pmc Cl(-) secretion in colonic epithelial cells induced by the vibrio parahaemolyticus hemolytic toxin related to thermostable direct hemolysin
    A Takahashi
    Department of Bacterial Infections, Research Institute for Microbial Diseases, Osaka University, 3 1, Yamadaoka, Suita, Osaka 565 0871, 770 8503, Japan
    Infect Immun 68:5435-8. 2000
    ..In cultured human colonic epithelial cells, TRH increases Cl(-) secretion, followed by elevation of intracellular calcium...
  20. ncbi request reprint Talin, a host cell protein, interacts directly with the translocated intimin receptor, Tir, of enteropathogenic Escherichia coli, and is essential for pedestal formation
    V V Cantarelli
    Department of Bacterial Infections, Research Institute for Microbial Diseases, Osaka University, Yamadaoka 3-1, Suita, Osaka 565-0871, Japan
    Cell Microbiol 3:745-51. 2001
    ..These findings demonstrate that talin is essential for EPEC-induced pedestal formation in infected cells...
  21. ncbi request reprint A pore-forming toxin produced by Aeromonas sobria activates cAMP-dependent Cl- secretory pathways to cause diarrhea
    Naomi Tanoue
    Department of Nutrition, School of Medicine, Tokushima University, 3 18 5 Kuramoto cho, Tokushima City, Tokushima 770 8503, Japan
    FEMS Microbiol Lett 242:195-201. 2005
    ..Moreover, ASH stimulated fluid accumulation in the iliac loop test, and glybenclamide and NPPB suppressed this fluid accumulation. Thus, cAMP-dependent Cl(-) secretory pathway could be related with diarrhea induced by A. sobria...
  22. ncbi request reprint Vibrio parahaemolyticus elevates interferon alpha production in intestinal-like epithelial Caco-2 cells
    Xin Lian
    Department of Nutrition and Metabolism, Institute of Health Biosciences, The University of Tokushima Graduate School, Kuramoto cho 3 18 15, Tokushima City, Tokushima 770 8503, Japan
    Can J Microbiol 53:1084-90. 2007
    ..Moreover, the production of infection-induced IFN-alpha was found in the mouse intestinal loop mucosal cells. V. parahaemolyticus infection of Caco-2 cells results in IFN-alpha production and the expression of IFN-regulated genes...
  23. ncbi request reprint Insulin activates ATP-sensitive potassium channels via phosphatidylinositol 3-kinase in cultured vascular smooth muscle cells
    Sonoko Yasui
    Department of Nutrition and Metabolism, University of Tokushima Graduate School, Tokushima, Japan
    J Vasc Res 45:233-43. 2008
    ..This study may contribute to our understanding of mechanisms of insulin resistance-associated hypertension...
  24. ncbi request reprint Growth-related renal type II Na/Pi cotransporter
    Hiroko Segawa
    Department of Nutrition, School of Medicine, Tokushima University, Kuramoto Cho 3, Tokushima City 770 8503, Japan
    J Biol Chem 277:19665-72. 2002
    ..The finding of the present study suggest that the type IIc is a growth-related renal Na/P(i) cotransporter, which has a high affinity for P(i) and is electroneutral...
  25. ncbi request reprint Modulation of pathogenicity with norepinephrine related to the type III secretion system of Vibrio parahaemolyticus
    Masayuki Nakano
    Department of Nutrition and Metabolism, Institute of Health Biosciences, University of Tokushima, Tokushima, 770 8503, Japan
    J Infect Dis 195:1353-60. 2007
    ..We examined the effect of NE on the pathogenicity of Vibrio parahaemolyticus with regard to its type III secretion systems (TTSSs)...
  26. ncbi request reprint Molecular mechanisms of the inhibitory effects of bupivacaine, levobupivacaine, and ropivacaine on sarcolemmal adenosine triphosphate-sensitive potassium channels in the cardiovascular system
    Takashi Kawano
    Department of Anesthesiology, Tokushima University School of Medicine, Kuramoto, Tokushima, 770 8503, Japan
    Anesthesiology 101:390-8. 2004
    ..The authors investigated the effects of local anesthetics on the activity of reconstituted KATP channels encoded by inwardly rectifying potassium channel (Kir6.0) and sulfonylurea receptor (SUR) subunits...
  27. ncbi request reprint Decreased blood levels of lactic acid and urinary excretion of 3-methylhistidine after exercise by chronic taurine treatment in rats
    Sachinobu Manabe
    Department of Nutrition, The University of Tokushima, School of Medicine, 3 18 Kuramoto cho, Tokushima 770 8503, Japan
    J Nutr Sci Vitaminol (Tokyo) 49:375-80. 2003
    ..These results indicate taurine treatment is useful for reducing physical fatigue and muscle damage during exercise training in rats, presumably due to antioxidant property and improvement of muscle and cardiac functions by taurine...
  28. pmc Association of the urease gene with enterohemorrhagic Escherichia coli strains irrespective of their serogroups
    M Nakano
    Department of Bacterial Infections, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan
    J Clin Microbiol 39:4541-3. 2001
    ..The results suggest that the urease gene can be a useful genetic marker for the detection of EHEC strains and for the diagnosis of infections caused by EHEC strains in the clinical situation...
  29. doi request reprint Mechanisms of impaired glucose tolerance and insulin secretion during isoflurane anesthesia
    Katsuya Tanaka
    Department of Anesthesiology, Tokushima University School of Medicine, Japan
    Anesthesiology 111:1044-51. 2009
    ..The authors hypothesized that isoflurane inhibits glucose-induced inhibition of adenosine triphosphate-sensitive potassium channel activity in pancreatic beta cells, which could result in impaired insulin secretion and glucose tolerance...
  30. ncbi request reprint Human airway trypsin-like protease stimulates human bronchial fibroblast proliferation in a protease-activated receptor-2-dependent pathway
    Rie Matsushima
    Dept of Nutrition and Metabolism, Graduate School of Nutrition and Bioscience, Univ of Tokushima, 3 18 15 Kuramoto cho, Tokushima, Japan 770 8503
    Am J Physiol Lung Cell Mol Physiol 290:L385-95. 2006
    ..These results indicate that HAT stimulates fibroblast proliferation in bronchial airways through a PAR-2-dependent MEK-MAPK mediated pathway and that HAT is linked to airway processes involving fibroblasts...
  31. ncbi request reprint Bezafibrate improves bacterial lipopolysaccharide-induced dyslipidemia and anorexia in rats
    Nagakatsu Harada
    Department of Nutrition and Metabolism, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima City, 770 8503, Japan
    Metabolism 56:517-22. 2007
    ..These results suggest that bezafibrate may be an effective drug not only for impaired triacylglycerol metabolism, but also for anorexia in cachectic states induced by bacterial infections...
  32. ncbi request reprint Molecular cloning of a murine glycerol-3-phosphate acyltransferase-like protein 1 (xGPAT1)
    Nagakatsu Harada
    Department of Nutrition and Metabolism, Institute of Health Biosciences, University of Tokushima Graduate School, 3 18 15, Kuramoto Cho, Tokushima City 770 8503, Japan
    Mol Cell Biochem 297:41-51. 2007
    ..xGPAT1 was distributed in the membrane fraction and showed GPAT activity when epitope-tagged xGPAT1 was expressed in Chinese hamster ovary (CHO)-K1 cells...
  33. ncbi request reprint Isoflurane activates sarcolemmal adenosine triphosphate-sensitive potassium channels in vascular smooth muscle cells: a role for protein kinase A
    Katsuya Tanaka
    Department of Anesthesiology, Tokushima University School of Medicine, Kuramoto, Tokushima, Japan
    Anesthesiology 106:984-91. 2007
    ..Studies of the interaction of volatile anesthetics with vascular K(ATP) channels have been limited. In the current study, the authors investigated the molecular mechanism of isoflurane's action on vascular K(ATP) channels...
  34. ncbi request reprint Molecular mechanisms underlying ketamine-mediated inhibition of sarcolemmal adenosine triphosphate-sensitive potassium channels
    Takashi Kawano
    Department of Anesthesiology, Tokushima University School of Medicine, Tokushima, Japan
    Anesthesiology 102:93-101. 2005
    ..1 or Kir6.2) and sulfonylurea receptors (SUR1, SUR2A, or SUR2B)...
  35. ncbi request reprint The nucleoside and nucleotide mixture (OG-VI) rescues intestinal-like epithelial cells from the cytotoxicity of chemotherapeutic agents
    Kaori Ono
    Department of Nutrition and Metabolism, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    J Med Invest 54:235-42. 2007
    ..Thus, we have demonstrated that OG-VI rescues cells from the cytotoxic effects of several chemotherapeutic agents...
  36. doi request reprint Beta-adrenergic-AMPK pathway phosphorylates acetyl-CoA carboxylase in a high-epinephrine rat model, SPORTS
    Atsushi Hattori
    Department of Nutrition and Metabolism, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    Obesity (Silver Spring) 18:48-54. 2010
    ..Our results suggest that beta-AR-regulated ACC activity would be a target for treating lifestyle-related diseases, such as obesity...
  37. ncbi request reprint Clinically relevant concentrations of propofol have no effect on adenosine triphosphate-sensitive potassium channels in rat ventricular myocytes
    Takashi Kawano
    Department of Anesthesiology, Tokushima University School of Medicine, Tokushima, Japan
    Anesthesiology 96:1472-7. 2002
    ....
  38. ncbi request reprint Chronic feeding of a nitric oxide synthase inhibitor induces postprandial hypertriglyceridemia in type 2 diabetic model rats, Otsuka Long-Evans Tokushima Fatty rats, but not in nondiabetic rats
    Yutaka Nakaya
    Department of Nutrition, School of Medicine, The University of Tokushima, Tokushima City, Japan
    Metabolism 51:702-7. 2002
    ..These results suggest that diabetes, when associated with endothelial dysfunction, results in greater abnormalities in lipid, as well as glucose metabolism...
  39. doi request reprint Hyperglycemia impairs isoflurane-induced adenosine triphosphate-sensitive potassium channel activation in vascular smooth muscle cells
    Takashi Kawano
    Department of Anesthesiology, Tokushima University School of Medicine, 3 18 15 Kuramoto, Tokushima 770 8503, Japan
    Anesth Analg 106:858-64, table of contents. 2008
    ..Isoflurane activates vascular adenosine triphosphate sensitive potassium (K(ATP)) channels, and may induce vasodilation. In the present study, we investigated whether hyperglycemia modifies isoflurane activation of vascular K(ATP) channel...
  40. doi request reprint Effects of dopamine on ATP-sensitive potassium channels in porcine coronary artery smooth-muscle cells
    Hiroaki Kawano
    Department of Anesthesiology, Tokushima University School of Medicine, Tokushima, Japan
    J Cardiovasc Pharmacol 51:196-201. 2008
    ..We therefore investigated the direct effects of dopamine on coronary KATP-channel activity...
  41. ncbi request reprint Esophageal xanthoma: report of two cases and a review of the literature
    Mitsuyoshi Hirokawa
    Department of Pathology, University of Tokushima School of Medicine, 3 18 15 Kuramoto cho, Tokushima 770 8503, Japan
    J Gastroenterol Hepatol 18:1105-8. 2003
    ..The etiology of esophageal xanthoma remains unclear. We emphasize that esophageal xanthomas may have been erroneously diagnosed as an ectopic sebaceous gland on endoscopic examination...
  42. ncbi request reprint The effects of extracellular pH on vasopressin inhibition of ATP-sensitive K+ channels in vascular smooth muscle cells
    Takashi Kawano
    Department of Anesthesiology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    Anesth Analg 105:1714-9, table of contents. 2007
    ..In the present study, we investigated whether extracellular acidification modifies the inhibition of vascular K(ATP) channels by AVP...
  43. ncbi request reprint Endothelin-1(1-31) levels are increased in atherosclerotic lesions of the thoracic aorta of hypercholesterolemic hamsters
    Kazuaki Mawatari
    Department of Nutrition, School of Medicine, Tokushima University, Tokushima, 3 18 15 Kuramoto cho, Tokushima 770 8503, Japan
    Atherosclerosis 175:203-12. 2004
    ..However, the pathological role of ET-1(1-31) in atherosclerosis remains unclear. The aim of this study was to clarify vasoconstrictive response and expression of ET-1(1-31) in atherosclerotic aorta...
  44. ncbi request reprint New water disinfection system using UVA light-emitting diodes
    A Hamamoto
    Department of Nutrition and Metabolism, Institute of Health Biosciences, The University of Tokushima Graduate School, Kuramoto Cho, Tokushima, Tokushima, Japan
    J Appl Microbiol 103:2291-8. 2007
    ..To evaluate the ability of high-energy ultraviolet A (UVA) light-emitting diode (LED) to inactivate bacteria in water and investigate the inactivating mechanism of UVA irradiation...
  45. ncbi request reprint NO-1886, a lipoprotein lipase activator, attenuates contraction of rat intestinal ring preparations
    Qishisan Wu
    Department of Nutrition and Metabolism, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    J Med Invest 55:61-70. 2008
    ..Administration of NO-1886 attenuated the obesity-induced hypercontractility of the colonic rings of OLETF rats. Thus, intestinal contractile system would be a novel pharmacological target of the lipoprotein lipase activator NO-1886...
  46. ncbi request reprint L-DOPA inhibits nitric oxide-dependent vasorelaxation via production of reactive oxygen species in rat aorta
    - Yinhua
    Department of Anesthesiology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    J Med Invest 56:120-9. 2009
    ..Involvement of nitric oxide (NO) in the effect of L-DOPA on vascular smooth muscle was studied by using N(omega)-Nitro-L-arginine (L-NNA), Sodium nitroprusside (SNP) in endothelium-intact and endothelium-denuded aortic rings...
  47. ncbi request reprint Effect of sarpogrelate hydrochloride, a 5-HT2 blocker, on insulin resistance in Otsuka Long-Evans Tokushima fatty rats (OLETF rats), a type 2 diabetic rat model
    Eiko Takishita
    Department of Nutrition, School of Medicine, Tokushima University, Tokushima City, Japan
    J Cardiovasc Pharmacol 43:266-70. 2004
    ..A plasma adrenaline level also rose significantly by injection of the 5-HT and was prevented by pretreatment of sarpogrelate. These results indicate that sarpogrelate improves insulin resistance in type 2 diabetic rats...
  48. ncbi request reprint Taurine alters respiratory gas exchange and nutrient metabolism in type 2 diabetic rats
    Nagakatsu Harada
    Department of Nutrition, School of Medicine, The University of Tokushima, 3 18 15, Kuramoto Cho, Tokushima City, 770 8503, Japan
    Obes Res 12:1077-84. 2004
    ..To assess the effect of taurine supplementation on respiratory gas exchange, which might reflect the improved metabolism of glucose and/or lipid in the type 2 diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats...
  49. ncbi request reprint Catecholamine-induced stimulation of growth in Vibrio species
    M Nakano
    Department of Nutrition and Metabolism, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    Lett Appl Microbiol 44:649-53. 2007
    ....
  50. ncbi request reprint Localization of the 31-amino-acid endothelin-1 in hamster tissue
    Sae Kakui
    Department of Nutrition, School of Medicine, Tokushima University, Tokushima, 3 18 15 Kuramoto cho, 770 8503, Tokushima, Japan
    Life Sci 74:1435-43. 2004
    ..In the kidney, ET-1(1-31)-like IR was slightly higher than ET-1(1-21). These results suggest that ET-1(1-31) might have physiological roles distinct from those of ET-1(1-21) in some hamster tissues...
  51. ncbi request reprint Angiotensin II inhibits insulin-induced actin stress fiber formation and glucose uptake via ERK1/2
    Hossein Nazari
    Department of Nutrition and Metabolism, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    J Med Invest 54:19-27. 2007
    ....
  52. ncbi request reprint Cloning and establishment of a line of rats for high levels of voluntary wheel running
    Masaki Morishima-Yamato
    Department of Nutrition, School of Medicine, The University of Tokushima, 3 18 15, Tokushima City, 770 8503, Japan
    Life Sci 77:551-61. 2005
    ....
  53. ncbi request reprint Hfq regulates anti-oxidative ability in Vibrio parahaemolyticus
    Zehong Su
    Department of Preventive Environment and Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School, Kuramoto cho 3 18 15, Tokushima City, Tokushima, Japan
    J Gen Appl Microbiol 56:181-6. 2010
    ..Genetic experiments indicated that the gene expression of sod and kat was up-regulated in the mutant strain. These results indicate that Hfq down-regulates CAT and SOD activity, and Hfq is associated with the oxidative stress response...
  54. ncbi request reprint The role of nitric oxide in striatal acetylcholine release induced by N-methyl-D-aspartate
    Y Ikarashi
    Department of Neuropsychopharmacology Tsumura, Gunma University, School of Medicine, Maebashi, Japan
    Neurochem Int 33:255-61. 1998
    ..These results suggest that NO induced by NMDA receptor-mediated mechanism in cholinergic neurons may mediate an inhibitory regulation of ACh release...
  55. ncbi request reprint A toxicological evaluation of a claudin modulator, the C-terminal fragment of Clostridium perfringens enterotoxin, in mice
    H Suzuki
    Laboratory of Bio Functional Molecular Chemistry, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan
    Pharmazie 66:543-6. 2011
    ..These results indicate that development of a less antigenic claudin modulator will be essential for future clinical application of a C-CPE-based mucosal absorption enhancer...
  56. ncbi request reprint Reactive oxygen species induced by diamide inhibit insulin-induced ATP-sensitive potassium channel activation in cultured vascular smooth muscle cells
    Kazuaki Mawatari
    Department of Metabolism and Nutrition, University of Tokushima Graduate School, 3 18 15 Kuramoto cho, Tokushima, 770 8503, Japan
    Asia Pac J Clin Nutr 17:162-6. 2008
    ..This study may contribute to our understanding of mechanisms of insulin resistance-associated cardiovascular disease...
  57. ncbi request reprint Severe catabolic state after prolonged fasting in cirrhotic patients: effect of oral branched-chain amino-acid-enriched nutrient mixture
    Yutaka Nakaya
    Department of Nutrition, The University of Tokushima, School of Medicine, Japan
    J Gastroenterol 37:531-6. 2002
    ....
  58. doi request reprint Identification of cis-acting promoter sequences required for expression of the glycerol-3-phosphate acyltransferase 1 gene in mice
    Masaki Yoshida
    Department of Nutrition and Metabolism, Institute of Health Biosciences, University of Tokushima Graduate School, 3 18 15, Kuramoto Cho, Tokushima City, 770 8503, Japan
    Biochim Biophys Acta 1791:39-52. 2009
    ..Thus, promoter 1a was exclusively activated by routine feeding in vivo. Our results indicate differential roles of the two promoters in the regulation of hepatic GPAT1 gene expression in mice...
  59. ncbi request reprint The phytoestrogen ginsensoside Re activates potassium channels of vascular smooth muscle cells through PI3K/Akt and nitric oxide pathways
    Yutaka Nakaya
    Department of Nutrition and Metabolism, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    J Med Invest 54:381-4. 2007
    ..In conclusion, ginsenoside Re releases NO via a membrane sex steroid receptors, resulting in K(Ca) channel activation in vascular smooth muscle cells, promoting vasodilation and preventing severe arterial contraction...
  60. pmc Additional effects of silver nanoparticles on bactericidal efficiency depend on calcination temperature and dip-coating speed
    Nhung Thi Tuyet Le
    Department of Preventive Environment and Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima City, Tokushima, Japan
    Appl Environ Microbiol 77:5629-34. 2011
    ..The presence of Ag enhanced the photocatalytic inactivation rate of TiO(2), producing a more pronounced effect with increasing levels of catalyst loading...
  61. doi request reprint High density lipoprotein inhibits the activation of sterol regulatory element-binding protein-1 in cultured cells
    Masaki Yoshida
    Department of Nutrition and Metabolism, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima City, Japan
    FEBS Lett 584:1217-22. 2010
    ..These results suggest that HDL inhibits the activation of SREBP-1 through a cholesterol-dependent mechanism, which may play an important role in regulating lipid synthetic pathways mediated by SREBP-1...
  62. ncbi request reprint Monoamine oxidase A activity and norepinephrine level in hippocampus determine hyperwheel running in SPORTS rats
    Masaki Morishima
    Department of Nutrition and Metabolism, Institute of Health Biosciences, The University of Tokushima Graduate School, Kuramoto Cho, Tokushima City, Japan
    Neuropsychopharmacology 31:2627-38. 2006
    ..These results indicate that decreased MAOA activity, elevation of extracellular NE, and alpha(2)-adrenergic receptors in the hippocampus determine the neural basis of the psychological regulation of exercise behavior in SPORTS rats...
  63. ncbi request reprint Approach to novel functional foods for stress control 2. Microarray assessment of exercise in healthy volunteers
    Yutaka Nakaya
    Department of Nutrition, The University of Tokushima Graduate School, Japan
    J Med Invest 52:242-3. 2005
    ..In addition, strenuous exercise produced quite different expression pattern from those of psychological stress...
  64. ncbi request reprint Gastric inhibitory polypeptide is the major insulinotropic factor in K(ATP) null mice
    Katsushi Tsukiyama
    Department of Diabetes and Clinical Nutrition, Kyoto University Graduate School of Medicine, Kyoto 606 8507, Japan
    Eur J Endocrinol 151:407-12. 2004
    ..To determine if GIP is the insulinotropic factor in insulin secretion in K(ATP) channel-deficient mice, we generated double-knockout Kir6.2 and GIP receptor null mice and compared them with Kir6.2 knockout mice...
  65. pmc Listeriolysin O-induced membrane permeation mediates persistent interleukin-6 production in Caco-2 cells during Listeria monocytogenes infection in vitro
    Kohsuke Tsuchiya
    Department of Microbiology, Kyoto University Graduate School of Medicine, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501, Japan
    Infect Immun 73:3869-77. 2005
    ..monocytogenes. These results suggest that LLO is involved in IL-6 production in the late phase of infection through the formation of Ca2+-permeable pores and subsequent Ca2+-dependent modulation of signaling and gene expression...
  66. ncbi request reprint Gatifloxacin acutely stimulates insulin secretion and chronically suppresses insulin biosynthesis
    Chizumi Yamada
    Department of Diabetes and Clinical Nutrition, Graduate School of Medicine, Kyoto University, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Eur J Pharmacol 553:67-72. 2006
    ..Because the risk of potentially life-threatening dysglycemia is increased during gatifloxacin therapy, these findings have important implications for clinical practice...
  67. ncbi request reprint Expression of progesterone receptor B is associated with G0/G1 arrest of the cell cycle and growth inhibition in NIH3T3 cells
    Shinji Horiuchi
    Department of Molecular Genetics, Division of Molecular and Cell Therapeutics, Medical Institute of Bioregulation, Kyushu University, Tsurumihara 4546, Beppu, Oita, 874 0838, Japan
    Exp Cell Res 305:233-43. 2005
    ..Finally, we showed that PR-B modulation involved in the regulation of NIH3T3 cell proliferation was independent of nuclear estrogen receptor (ER) activity but dependent on non-genomic ER activity...
  68. ncbi request reprint Effect of high dietary fat on insulin secretion in genetically diabetic Goto-Kakizaki rats
    Wenbin Shang
    Department of Metabolism and Clinical Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Pancreas 25:393-9. 2002
    ..To clarify the effects of a high fat-diet on insulin secretion from genetically diabetic beta cells, Goto-Kakizaki rats and Wistar rats were subjected to oral glucose tolerance test (OGTT) after 12-week high-fat feeding...
  69. ncbi request reprint Effect of IS-741 on ethionine-induced acute pancreatitis in rats: relation to pancreatic acinar cell regeneration
    Tsunao Imamura
    Second Department of Internal Medicine, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8666, Japan
    J Gastroenterol 38:260-7. 2003
    ..Tissue destruction arising from neutrophil infiltration of the pancreas and other organs in acute pancreatitis is supposed to be suppressed by IS-741. We studied the effect of IS-741 on acute pancreatitis induced by DL-ethionine in rats...
  70. ncbi request reprint Transcription factors Csx/Nkx2.5 and GATA4 distinctly regulate expression of Ca2+ channels in neonatal rat heart
    Yan Wang
    Department of Cardiovascular Sciences, Oita University School of Medicine, 1 1 Idaigaoka, Hasama, Yufu, Oita 879 5593, Japan
    J Mol Cell Cardiol 42:1045-53. 2007
    ..5 overexpression. These results indicate that Csx/Nkx2.5 and GATA4 play important roles on the generation of pacemaker potentials modulating voltage-dependent Ca(2+) channels in the neonatal cardiomyocyte...
  71. ncbi request reprint Protection of dopaminergic neurons with a novel astrocyte modulating agent (R)-(-)-2-propyloctanoic acid (ONO-2506) in an MPTP-mouse model of Parkinson's disease
    Hiroyuki Kato
    Department of Neurology, Tohoku University School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    J Neurol Sci 208:9-15. 2003
    ..Pharmacological modulation of astrocytes may offer a novel therapeutic strategy for Parkinson's disease...
  72. pmc Hyperphosphorylation of a mitochondrial protein, prohibitin, is induced by calyculin A in a rice lesion-mimic mutant cdr1
    Akira Takahashi
    Laboratory of Plant Molecular Genetics, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma, 630 0101, Japan
    Plant Physiol 132:1861-9. 2003
    ....
  73. ncbi request reprint Sulfonylurea and non-sulfonylurea hypoglycemic agents: pharmachological properties and tissue selectivity
    Kazuaki Nagashima
    Department of Diabetes and Clinical Nutrition, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Diabetes Res Clin Pract 66:S75-8. 2004
    ..We also suggest possible risk in the use of certain hypoglycemic agents in patients with ischemic heart disease...
  74. ncbi request reprint Performance of bipolar forceps during coagulation and its dependence on the tip material: a quantitative experimental assay. Technical note
    Takeshi Mikami
    Department of Neurosurgery, Sapporo Medical University, Sapporo, Japan
    J Neurosurg 100:133-8. 2004
    ..Adherence to bipolar forceps was dependent on both the material in the tips and the roughness of this material. The gold-plated bipolar forceps demonstrated the best performance...
  75. ncbi request reprint Sterilization using 365 nm UV-LED
    Noriyuki Yagi
    Institute of Technology and Science, The University of Tokushima
    Conf Proc IEEE Eng Med Biol Soc 2007:5842-5. 2007
    ..coli and Vibrio parahaemolyticus by UV-LED exposure of 30 minutes and 10 minutes, respectively. These results suggest that the UV-LED has sterilization effects. Therefore, UV-LED can be used as a sterilization device...
  76. ncbi request reprint 14-3-3 and calmodulin control subcellular distribution of Kir/Gem and its regulation of cell shape and calcium channel activity
    Pascal Beguin
    Epithelial Cell Biology Laboratory, Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore 138673, Republic of Singapore
    J Cell Sci 118:1923-34. 2005
    ....
  77. ncbi request reprint Apoptosis of intestinal crypt epithelium after Cryptosporidium parvum infection
    Takeshi Sasahara
    Department of Microbiology and Parasitology, Kitasato University School of Medicine, 1 15 1 Kitasato, Sagamihara, Kanagawa 228 8555, Japan
    J Infect Chemother 9:278-81. 2003
    ..parvum infection, and that epithelial apoptosis may have a significant role in the pathogenesis of cryptosporidiosis...
  78. ncbi request reprint Combination therapy of exercise and angiotensin-converting enzyme inhibitor markedly improves insulin sensitivities in hypertensive patients with insulin resistance
    Manabu Kinoshita
    Kagawa Prefectural Shiratori Hospital, The University of Tokushima, Japan
    Circ J 66:655-8. 2002
    ..The combination of walking and ACEI further lowered blood concentrations of insulin and HOMA-R, which suggests that this treatment is beneficial for hypertensive patients with insulin resistance...
  79. ncbi request reprint Delayed persistent estrus induced by continuous lighting after inadequate acclimation in rats
    Sen Ichi Furudate
    Department of Laboratory Animal Science, Kitasato University School of Medicine, Sagamihara, Japan
    Exp Anim 54:93-5. 2005
    ....
  80. ncbi request reprint Placental and intestinal alkaline phosphatases are receptors for Aeromonas sobria hemolysin
    Akihiro Wada
    Department of Bacteriology, Institute of Tropical Medicine, Nagasaki University, Sakamoto, Nagasaki 852 8523, Japan
    Int J Med Microbiol 294:427-35. 2005
    ..Thus, both PLAP and IAP are very likely involved in the pathogenesis of diarrhea caused by this bacterial toxin...
  81. ncbi request reprint Contribution of estrogen receptor alpha to oncogenic K-Ras-mediated NIH3T3 cell transformation and its implication for escape from senescence by modulating the p53 pathway
    Kiyoko Kato
    Department of Molecular Genetics, Division of Molecular and Cell Therapeutics Medical Institute of Bioregulation, Kyushu University, Tsurumihara 4546, Beppu, Oita, Japan
    J Biol Chem 277:11217-24. 2002
    ..The data imply that the ERalpha-AP1 pathway activated by oncogenic K-Ras 4B mutant contributes to the NIH3T3 cells' transformation by modulating p53 transcriptional activity through MDM2...
  82. ncbi request reprint Resistance and susceptibility of plants to fungal pathogens
    Kazuhiro Toyoda
    The Sainsbury Laboratory, John Innes Centre, Colney Lane, Norwich NR4 7UH, UK
    Transgenic Res 11:567-82. 2002
    ..The knowledge accumulated in these studies will serve a fundamental basis for combating diseases in strategic molecular agriculture...
  83. ncbi request reprint [Relationship between cardiac 123I-metaiodobenzylguanidine scintigraphy and cardiovascular autonomic function test (standing test) in Parkinson's disease]
    Hideki Doi
    Department of Neurology, Higashi General Hospital of Nagoya
    Rinsho Shinkeigaku 48:56-9. 2008
    ..These results suggest that 123I-MIBG myocardial scintigraphy may be associated with the basal sympathetic nerve activity, but not with autonomic nervous response of the cardiovascular system in patients with PD...