Affiliation: The University of Tokushima
Kozai M, Kubo Y, Katakai T, Kondo H, Kiyonari H, Schaeuble K, et al
. Essential role of CCL21 in establishment of central self-tolerance in T cells. J Exp Med. 2017;214:1925-1935 pubmed publisher
..These results indicate a nonredundant role of CCL21Ser in the establishment of self-tolerance in T cells in the thymic medulla, and reveal a functional inequality among CCR7 ligands in vivo. ..
Takada K, Takahama Y. Positive-selection-inducing self-peptides displayed by cortical thymic epithelial cells. Adv Immunol. 2015;125:87-110 pubmed publisher
..Recent studies suggest unique mechanisms of antigen processing in cTECs for the production of positively selecting MHC-bound self-peptides. ..
Takada K, Kondo K, Takahama Y. Generation of Peptides That Promote Positive Selection in the Thymus. J Immunol. 2017;198:2215-2222 pubmed publisher
..Recent studies on the role of positive selection in the functional tuning of T cells are also discussed. ..
Sakata M, Ohigashi I, Takahama Y. Cellularity of Thymic Epithelial Cells in the Postnatal Mouse. J Immunol. 2018;200:1382-1388 pubmed publisher
..These results suggest that the use of conventional enzymatic digestion methods for the isolation of TECs may have resulted in the underestimation of the cellularity, and possibly the biology, of TECs. ..
Takahama Y, Tanaka K, Murata S. Modest cortex and promiscuous medulla for thymic repertoire formation. Trends Immunol. 2008;29:251-5 pubmed publisher
..These results could offer fundamental new insights into the molecular mechanisms of T-cell repertoire selection. ..
Takahama Y, Takada K, Murata S, Tanaka K. ?5t-containing thymoproteasome: specific expression in thymic cortical epithelial cells and role in positive selection of CD8+ T cells. Curr Opin Immunol. 2012;24:92-8 pubmed publisher
..Here we summarize the structure and expression of the thymoproteasome and discuss how it regulates the positive selection of CD8+ T cells...
Ohigashi I, Zuklys S, Sakata M, Mayer C, Hamazaki Y, Minato N, et al
. Adult Thymic Medullary Epithelium Is Maintained and Regenerated by Lineage-Restricted Cells Rather Than Bipotent Progenitors. Cell Rep. 2015;13:1432-1443 pubmed publisher
..These results indicate that the adult thymic medullary epithelium is maintained and regenerated by mTEC-lineage cells that pass beyond the bipotent stage during early ontogeny. ..
Kondo K, Takada K, Takahama Y. Antigen processing and presentation in the thymus: implications for T cell repertoire selection. Curr Opin Immunol. 2017;46:53-57 pubmed publisher
..Here, we briefly summarize those machineries, focusing on the biology of cortical and medullary thymic epithelial cells. ..