K Shibata

Summary

Affiliation: The University of Shiga Prefecture
Country: Japan

Publications

  1. pmc Fate of dietary tryptophan in young Japanese women
    Chiaki Hiratsuka
    Department of Food Science and Nutrition, School of Human Cultures, University of Shiga Prefecture, Hikone, Japan
    Int J Tryptophan Res 5:33-47. 2012
  2. ncbi request reprint Urinary excretion levels of water-soluble vitamins in pregnant and lactating women in Japan
    Katsumi Shibata
    Department of Food Science and Nutrition, School of Human Cultures, The University of Shiga Prefecture
    J Nutr Sci Vitaminol (Tokyo) 59:178-86. 2013
  3. doi request reprint Pantothenic acid refeeding diminishes the liver, perinephrical fats, and plasma fats accumulated by pantothenic acid deficiency and/or ethanol consumption
    Katsumi Shibata
    Department of Food Science and Nutrition, School of Human Cultures, University of Shiga Prefecture, Hikone, Japan
    Nutrition 29:796-801. 2013
  4. ncbi request reprint Increased conversion of tryptophan to nicotinamide in rats by dietary valproate
    Katsumi Shibata
    Department of Food Science and Nutrition, School of Human Cultures, The University of Shiga Prefecture, Hikone, Shiga, Japan
    Biosci Biotechnol Biochem 77:295-300. 2013
  5. doi request reprint The metabolites in the tryptophan degradation pathway might be useful to determine the tolerable upper intake level of tryptophan intake in rats
    Katsumi Shibata
    Department of Food Science and Nutrition, School of Human Cultures, The University of Shiga Prefecture, Shiga, Japan
    J Nutr 142:2227S-2230S. 2012
  6. doi request reprint Simultaneous high-performance liquid chromatography determination of coenzyme A, dephospho-coenzyme A, and acetyl-coenzyme A in normal and pantothenic acid-deficient rats
    Katsumi Shibata
    Department of Food Science and Nutrition, School of Human Cultures, University of Shiga Prefecture, Hikone, Shiga 522 8533, Japan
    Anal Biochem 430:151-5. 2012
  7. ncbi request reprint The urinary excretory ratio of nicotinamide catabolites was associated with the conversion ratio of tryptophan to nicotinamide in growing rats fed a niacin-free 20% casein diet
    Katsumi Shibata
    Department of Food Science and Nutrition, School of Human Cultures, The University of Shiga Prefecture, Hikone, Shiga, Japan
    Biosci Biotechnol Biochem 76:186-8. 2012
  8. ncbi request reprint Intra- and inter-individual variations of blood and urinary water-soluble vitamins in Japanese young adults consuming a semi-purified diet for 7 days
    Katsumi Shibata
    School of Human Cultures, The University of Shiga Prefecture, Hikone, Shiga, Japan
    J Nutr Sci Vitaminol (Tokyo) 55:459-70. 2009
  9. ncbi request reprint Effects of excess pantothenic acid administration on the other water-soluble vitamin metabolisms in rats
    Katsumi Shibata
    Laboratory of Food Science, Department of Life Style Studies, School of Human Cultures, The University of Shiga Prefecture, Hikone, Shiga 522 8533, Japan
    J Nutr Sci Vitaminol (Tokyo) 51:385-91. 2005
  10. ncbi request reprint Fluorometric determination of 2-oxoadipic acid, a common metabolite of tryptophan and lysine, by high-performance liquid chromatography with pre-chemical derivatization
    Katsumi Shibata
    Department of Food Science and Nutrition, School of Human Cultures, The University of Shiga Prefecture, 2500 Hassaka, Hikone, Shiga 522 8533, Japan
    Biosci Biotechnol Biochem 75:185-7. 2011

Collaborators

Detail Information

Publications76

  1. pmc Fate of dietary tryptophan in young Japanese women
    Chiaki Hiratsuka
    Department of Food Science and Nutrition, School of Human Cultures, University of Shiga Prefecture, Hikone, Japan
    Int J Tryptophan Res 5:33-47. 2012
    ....
  2. ncbi request reprint Urinary excretion levels of water-soluble vitamins in pregnant and lactating women in Japan
    Katsumi Shibata
    Department of Food Science and Nutrition, School of Human Cultures, The University of Shiga Prefecture
    J Nutr Sci Vitaminol (Tokyo) 59:178-86. 2013
    ..These results provide valuable information for setting the Dietary Reference Intakes of water-soluble vitamins for pregnant and lactating women. ..
  3. doi request reprint Pantothenic acid refeeding diminishes the liver, perinephrical fats, and plasma fats accumulated by pantothenic acid deficiency and/or ethanol consumption
    Katsumi Shibata
    Department of Food Science and Nutrition, School of Human Cultures, University of Shiga Prefecture, Hikone, Japan
    Nutrition 29:796-801. 2013
    ..CoA is an essential coenzyme in fat metabolism. The aim of this study was to determine whether PaA deficiency causes the accumulation of tissue fats and, if so, can refeeding of PaA decrease such accumulated fat...
  4. ncbi request reprint Increased conversion of tryptophan to nicotinamide in rats by dietary valproate
    Katsumi Shibata
    Department of Food Science and Nutrition, School of Human Cultures, The University of Shiga Prefecture, Hikone, Shiga, Japan
    Biosci Biotechnol Biochem 77:295-300. 2013
    ..01; 0% vs. 1.0% VPA). This increase was dependent on the intake of VPA...
  5. doi request reprint The metabolites in the tryptophan degradation pathway might be useful to determine the tolerable upper intake level of tryptophan intake in rats
    Katsumi Shibata
    Department of Food Science and Nutrition, School of Human Cultures, The University of Shiga Prefecture, Shiga, Japan
    J Nutr 142:2227S-2230S. 2012
    ..These results show that the urinary excretory ratio of anthranilic acid:kynurenic acid is potentially the most sensitive and appropriate surrogate breakpoint index to predict the UL of L-Trp...
  6. doi request reprint Simultaneous high-performance liquid chromatography determination of coenzyme A, dephospho-coenzyme A, and acetyl-coenzyme A in normal and pantothenic acid-deficient rats
    Katsumi Shibata
    Department of Food Science and Nutrition, School of Human Cultures, University of Shiga Prefecture, Hikone, Shiga 522 8533, Japan
    Anal Biochem 430:151-5. 2012
    ....
  7. ncbi request reprint The urinary excretory ratio of nicotinamide catabolites was associated with the conversion ratio of tryptophan to nicotinamide in growing rats fed a niacin-free 20% casein diet
    Katsumi Shibata
    Department of Food Science and Nutrition, School of Human Cultures, The University of Shiga Prefecture, Hikone, Shiga, Japan
    Biosci Biotechnol Biochem 76:186-8. 2012
    ..This indicates the possibility that the conversion ratio can be deduced from the excretory ratio...
  8. ncbi request reprint Intra- and inter-individual variations of blood and urinary water-soluble vitamins in Japanese young adults consuming a semi-purified diet for 7 days
    Katsumi Shibata
    School of Human Cultures, The University of Shiga Prefecture, Hikone, Shiga, Japan
    J Nutr Sci Vitaminol (Tokyo) 55:459-70. 2009
    ..These results showed that oral administration of constant of water-soluble vitamins generally decreased intra-individual variation, while individual differences in urinary vitamin excretion were observed...
  9. ncbi request reprint Effects of excess pantothenic acid administration on the other water-soluble vitamin metabolisms in rats
    Katsumi Shibata
    Laboratory of Food Science, Department of Life Style Studies, School of Human Cultures, The University of Shiga Prefecture, Hikone, Shiga 522 8533, Japan
    J Nutr Sci Vitaminol (Tokyo) 51:385-91. 2005
    ..As for the calcium pantothenate, it was found that the 3% level in the diet was the lowest-observed-adverse-effect-level (LOAEL) and the 1% level was the no-observed-adverse-effect-level (NOAEL)...
  10. ncbi request reprint Fluorometric determination of 2-oxoadipic acid, a common metabolite of tryptophan and lysine, by high-performance liquid chromatography with pre-chemical derivatization
    Katsumi Shibata
    Department of Food Science and Nutrition, School of Human Cultures, The University of Shiga Prefecture, 2500 Hassaka, Hikone, Shiga 522 8533, Japan
    Biosci Biotechnol Biochem 75:185-7. 2011
    ..The limit of quantification was 1 pmol per injection, sufficiently sensitive for the determination of 2-oxoadipic acid in human and experimental animal urine...
  11. ncbi request reprint Values of water-soluble vitamins in blood and urine of Japanese young men and women consuming a semi-purified diet based on the Japanese Dietary Reference Intakes
    Katsumi Shibata
    School of Human Cultures, The University of Shiga Prefecture, Hikone, Shiga 522 8533, Japan
    J Nutr Sci Vitaminol (Tokyo) 51:319-28. 2005
    ..In future, an experiment with various age groups and re-evaluation by repeated experiments will provide more accurate values...
  12. ncbi request reprint Nutritional factors that regulate on the conversion of L-tryptophan to niacin
    K Shibata
    Department of Life Style Studies, School of Human Cultures, University of Shiga Prefecture, Hikone, Japan
    Adv Exp Med Biol 467:711-6. 1999
    ..In the effects of carbohydrate, the conversion ratio was higher in diets containing starch than in diets containing sucrose...
  13. ncbi request reprint Effect of dietary histidine content on the change in content of skin urocanic acid isomers in hairless mice irradiated with ultraviolet B
    K Shibata
    Department of Life Style Studies, School of Human Cultures, The University of Shiga Prefecture, Hikone, Japan
    Biosci Biotechnol Biochem 65:1415-8. 2001
    ..Therefore, the absolute cis-urocanic acid content in the skin was almost the same among the three groups. These results indicate that the increased histidine intake strengthened UVB protection without any decrease in immune suppression...
  14. ncbi request reprint Effects of dietary pyrazinamide, an antituberculosis agent, on the metabolism of tryptophan to niacin and of tryptophan to serotonin in rats
    K Shibata
    Department of Life Style Studies, School of Human Cultures, The University of Shiga Prefecture, Hikone, Shiga, Japan
    Biosci Biotechnol Biochem 65:1339-46. 2001
    ..It is suggested from these results that the action of pyrazinamide against tuberculosis is linked to the increase in turnover of NAD and to the increased content of NAD in the host cells...
  15. ncbi request reprint Reversed-phase high-performance liquid chromatography of nicotinic acid mononucleotide for measurement of quinolinate phosphoribosyltransferase
    K Shibata
    Department of Life Style Studies, School of Human Cultures, The University of Shiga Prefecture, Hikone, Japan
    J Chromatogr B Biomed Sci Appl 749:281-5. 2000
    ..The total HPLC analysis time was approximately 20 min...
  16. ncbi request reprint Efficiency of D-tryptophan as Niacin in rats
    K Shibata
    Department of Life Style Studies, School of Human Cultures, University of Shiga Prefecture, Japan
    Biosci Biotechnol Biochem 64:206-9. 2000
    ..The efficiency of D-tryptophan as niacin was thus investigated by using weanling rats. The availability of D-tryptophan was almost the same as that in L-tryptophan as the precursor of niacin and was 1/6 as active as niacin...
  17. ncbi request reprint Comparison of the effects of di(2-ethylhexyl)phthalate, a peroxisome proliferator, on the vitamin metabolism involved in the energy formation in rats fed with a casein or gluten diet
    Katsumi Shibata
    Laboratories of Food Science and Nutrition, Department of Life Style Studies, School of Human Cultures, The University of Shiga Prefecture, Shiga
    Biosci Biotechnol Biochem 70:1331-7. 2006
    ..We also investigated the effects of DEHP on the urinary excretion of other vitamins. DEHP administration resulted in decreased urinary excretion of vitamin B(1), vitamin B(2), and pantothenic acid...
  18. ncbi request reprint Association between 24 hour urinary α-tocopherol catabolite, 2,5,7,8-tetramethyl-2(2'-carboxyethyl)-6-hydroxychroman (α-CEHC) and α-tocopherol intake in intervention and cross-sectional studies
    Eri Imai
    Department of Food Science and Nutrition, School of Human Cultures, The University of Shiga Prefecture, Hikone, Shiga, Japan
    Asia Pac J Clin Nutr 20:507-13. 2011
    ....
  19. ncbi request reprint Influence of adenine-induced renal failure on tryptophan-niacin metabolism in rats
    T Fukuwatari
    Course of Food Science and Nutrition, Department of Life Style Studies, School of Human Cultures, The University of Shiga Prefecture, Hikone, Japan
    Biosci Biotechnol Biochem 65:2154-61. 2001
    ..It was concluded from these results that the conversion of tryptophan to niacin is due to only the liver enzymes and that the role of the kidney would be extremely low...
  20. ncbi request reprint Phthalate esters enhance quinolinate production by inhibiting alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD), a key enzyme of the tryptophan pathway
    Tsutomu Fukuwatari
    Laboratory of Food Science and Nutrition, Department of Life Style Studies, School of Human Cultures, University of Shiga Prefecture, Hikone, Japan
    Toxicol Sci 81:302-8. 2004
    ....
  21. ncbi request reprint [Effect of feeding with a poisonous mushroom Clitocybe acromelalga on the metabolism of tryptophan-niacin in rats]
    T Fukuwatari
    Department of Life Style Studies, School of Human Cultures, University of Shiga Prefecture: 2500, Hassaka-cho, Hikone, Shiga 522-8533, Japan
    Shokuhin Eiseigaku Zasshi 42:190-6. 2001
    ..The blood levels of tryptophan and NAD on day 1 were also higher in the toadstool group. Accordingly, intake of Clitocybe acromelalga appeared to increase the conversion of tryptophan to niacin...
  22. ncbi request reprint The effects of phthalate esters on the tryptophan-niacin metabolism
    Tsutomu Fukuwatari
    Laboratories of Food Science and Nutrition, Department of Life Style Studies, School of Human Cultures, The University of Shiga Prefecture, Hikone, Shiga 522 8533, Japan
    Adv Exp Med Biol 527:659-64. 2003
    ..We conclude that PhE such as DEHP and DBP disturbed the Tryptophan-niacin metabolism...
  23. ncbi request reprint [Effects of excess nicotinic acid on growth and the urinary excretion of B-group vitamins and the metabolism of tryptophan in weaning rats]
    Tsutomu Fukuwatari
    Department of Food Science and Nutrition, School of Human Cultures, The University of Shiga Prefecture, Hikone, Shiga 5228533, Japan
    Shokuhin Eiseigaku Zasshi 50:80-4. 2009
    ..1% in diet, corresponding to 90 mg/kg body weight/day, and the lowest-observed-adverse-effect-level (LOAEL) was 0.3% in diet, corresponding to 270 mg/kg body weight/day...
  24. ncbi request reprint Comparison of the nicotinamide catabolism among rat strains
    Kei Takahashi
    Department of Food Science and Nutrition, School of Human Cultures, The University of Shiga Prefecture, Hikone, Shiga, Japan
    Biosci Biotechnol Biochem 73:274-9. 2009
    ..This study showed that Wistar, SD, ACI strains had similar water-soluble vitamin metabolism including nicotinamide catabolism...
  25. ncbi request reprint Conversion ratio of tryptophan to niacin in Japanese women fed a purified diet conforming to the Japanese Dietary Reference Intakes
    Tsutomu Fukuwatari
    Laboratories of Food Science and Nutrition, Departient of Life Style Studies, School of Human Cultures, The University of Shiga Prefecture, 2500 Hassakacho, Hikone, Japan
    J Nutr Sci Vitaminol (Tokyo) 50:385-91. 2004
    ..It was calculated that if the excretory percentage of niacin metabolites in the urine were 60%, of the tryptophan ingested, the conversion factor would be a value of 67, meaning that is 67 mg of tryptophan is equal to 1 mg of niacin...
  26. ncbi request reprint [Effects of excess vitamin B1 or vitamin B2 on growth and urinary excretion of water-soluble vitamins in weaning rats]
    Tsutomu Fukuwatari
    Department of Food Science and Nutrition, School of Human Cultures, The University of Shiga Prefecture, Hikone, Shiga 5228533, Japan
    Shokuhin Eiseigaku Zasshi 50:70-4. 2009
    ..0% thiamin-HCl or 1.0% riboflavin did not induce apparent adverse effects, and the no-observed-adverse-effect-levels (NOAELs) for thiamin-HCl and riboflavin in rats might be 1.0% in diet, corresponding to 900 mg/kg body weight/day...
  27. ncbi request reprint [Effects of excess pyridoxine-HCl on growth and urinary excretion of water-soluble vitamins in weaning rats]
    Tsutomu Fukuwatari
    Department of Food Science and Nutrition, School of Human Cultures, The University of Shiga Prefecture, Hikone, Shiga 5228533, Japan
    Shokuhin Eiseigaku Zasshi 50:75-9. 2009
    ..1% in diet, corresponding to 90 mg/kg body weight/day, and lowest-observed-adverse-effect-level (LOAEL) was 0.5% in diet, corresponding to 450 mg/kg body weight/day...
  28. ncbi request reprint Comparison of metabolic fates of nicotinamide, NAD+ and NADH administered orally and intraperitoneally; characterization of oral NADH
    Naoko Kimura
    Laboratories of Food Science and Nutrition, Department of Life Style Studies, School of Human Cultures, The University of Shiga Prefecture, Japan
    J Nutr Sci Vitaminol (Tokyo) 52:142-8. 2006
    ..In fact, incubation of NADH at acidic pH to mimic the stomach resulted in rapid conversion of NADH to an unknown compound. Better understanding of the fate of oral NADH is needed for its therapeutic and supplemental use...
  29. ncbi request reprint Effects of dietary di(2-ethylhexyl)phthalate, a putative endocrine disrupter, on enzyme activities involved in the metabolism of tryptophan to niacin in rats
    Tsutomu Fukuwatari
    Laboratories of Food Science and Nutrition, Department of Life Style Studies, School of Human Cultures, The University of Shiga Prefecture, 2500 Hassaka cho, Hikone, Shiga, 522 8533, Japan
    Biochim Biophys Acta 1672:67-75. 2004
    ..However, we found that the activities in the liver and kidney did not decrease in the rat fed with DEHP-containing diet. We discuss the discrepancy between the metabolite results and the enzyme activities...
  30. ncbi request reprint Increased conversion ratio of tryptophan to niacin by dietary di-n-butylphthalate
    K Shibata
    Department of Life Studies, School of Human Cultures, The University of Shiga Prefecture, Hikone, Japan
    J Nutr Sci Vitaminol (Tokyo) 47:263-6. 2001
    ..From these results, the previous finding is possibly explained by DBP increasing the conversion ratio of tryptophan to niacin...
  31. ncbi request reprint Elevation of blood NAD level after moderate exercise in young women and mice
    T Fukuwatari
    Department of Life Style Studies, School of Human Cultures, The University of Shiga Prefecture, Hikone, Japan
    J Nutr Sci Vitaminol (Tokyo) 47:177-9. 2001
    ..These data are the first demonstration of moderate exercise raising the blood NAD levels in human and mice. Elevation of the blood NAD levels may reflect changes in niacin metabolism that occur in response to exercise...
  32. ncbi request reprint Vitamin intake in Japanese women college students
    Naoko Kimura
    Laboratory of Food Science, Department of Life Style Studies, School of Human Cultures, The University of Shiga Prefecture, 2500 Hassakacho, Hikone, Shiga 522 8533, Japan
    J Nutr Sci Vitaminol (Tokyo) 49:149-55. 2003
    ..Therefore, in consideration of their lifestyle, their energy intakes is considered adequate. In conclusion, a problem for student lifestyle is a shortage of food intake due to lack of exercise...
  33. ncbi request reprint High-fat diet lowers the nutritional status indicators of pantothenic acid in weaning rats
    Erina Yoshida
    Department of Food Science and Nutrition, School of Human Cultures, The University of Shiga Prefecture, Hikone, Shiga, Japan
    Biosci Biotechnol Biochem 74:1691-3. 2010
    ..The plasma, liver and adrenal pantothenic acid levels in the rats fed on the 30% fat diet were significantly lower than with the 5% fat diet. The results suggest that the high-fat diet affected pantothenic acid metabolism...
  34. ncbi request reprint [Effects of excess folic acid on growth and metabolism of water-soluble vitamins in weaning rats]
    Tsutomu Fukuwatari
    Department of Life Style Studies, The University of Shiga Prefecture, Shiga, Japan
    Shokuhin Eiseigaku Zasshi 49:51-5. 2008
    ..These results clearly showed that feeding a diet containing up to 1.0% folic acid did not affect the food intake, body weight gain, tissue weight, or urinary excretion of B-group vitamins in weaning rats...
  35. ncbi request reprint Effects of dietary di(2-ethylhexyl)phthalate on the metabolism of tryptophan to niacin in mice
    Mari Ohta
    Laboratories of Food Science and Nutrition, Department of Life Style Studies, School of Human Cultures, The University of Shiga Prefecture, Shiga, Japan
    Exp Anim 53:57-60. 2004
    ..The flux of niacin in the lower part of the Trp-niacin pathway in mice was enhanced by feeding with DEHP...
  36. ncbi request reprint Changes of pyridine nucleotide levels during adipocyte differentiation of mouse 3T3-L1 cells
    T Fukuwatari
    Department of Life Style Studies, School of Human Cultures, The University of Shiga Prefecture, Hikone, Japan
    Biosci Biotechnol Biochem 65:2565-8. 2001
    ..These results suggest that expression of the pyridine nucleotide biosynthesis genes is induced in the differentiation process...
  37. ncbi request reprint Growth-promoting activity of pyrazinoic acid, a putative active compound of antituberculosis drug pyrazinamide, in niacin-deficient rats through the inhibition of ACMSD activity
    Tsutomu Fukuwatari
    Department of Life Style Studies, School of Human Cultures, The University of Shiga Prefecture, Hikone, Japan
    Biosci Biotechnol Biochem 66:1435-41. 2002
    ..These results suggest that a derivative of POA metabolized by rats inhibited the ACMSD activity...
  38. ncbi request reprint Consideration of diurnal variations in human blood NAD and NADP concentrations
    Tsutomu Fukuwatari
    Department of Food Science and Nutrition, School of Human Cultures, The University of Shiga Prefecture, Hikone, Japan
    J Nutr Sci Vitaminol (Tokyo) 55:279-81. 2009
    ..The existence of a mechanism by which NAD and the NADP levels of the blood are constantly maintained by the adjustment of the amount of excretion to the urinary bladder, was suggested...
  39. ncbi request reprint Elucidation of the toxic mechanism of the plasticizers, phthalic acid esters, putative endocrine disrupters: effects of dietary di(2-ethylhexyl)phthalate on the metabolism of tryptophan to niacin in rats
    Tsutomu Fukuwatari
    Department of Life Style Studies, School of Human Cultures, The University of Shiga Prefecture, Hikone, Japan
    Biosci Biotechnol Biochem 66:705-10. 2002
    ..We conclude that PhE such as DEHP and DBP disturbed the tryptophan-niacin metabolism...
  40. ncbi request reprint Effects of stress on the urinary excretory pattern of niacin catabolites, the most reliable index of niacin status, in humans
    Hidemi Okamoto
    Laboratories of Food Science and Nutrition, Department of Life Style Studies, School of Human Cultures, The University of Shiga Prefecture, Hikone, Shiga 522 8533, Japan
    J Nutr Sci Vitaminol (Tokyo) 48:417-9. 2002
    ..Of the stresses, cold exposure significantly increased urinary excretory output of the niacin metabolites. The biosynthesis of nicotinamide from Trp seemed to be increased by cold exposure...
  41. ncbi request reprint Urinary excretory ratio of anthranilic acid/kynurenic acid as an index of the tolerable amount of tryptophan
    Alato Okuno
    Department of Life Style Studies, Laboratories of Food Science and Nutrition, School of Human Cultures, The University of Shiga Prefecture, Hikone, Shiga 522 8533, Japan
    Biosci Biotechnol Biochem 72:1667-72. 2008
    ..0 and 5.0% tryptophan-added groups. The urinary excretory ratio of AnA/KA was a high value for both the groups. These results suggest that the urinary ratio of AnA/KA could be a useful index to monitoran excessive tryptophan intake...
  42. doi request reprint Urinary excretion of vitamin B12 depends on urine volume in Japanese female university students and elderly
    Tsutomu Fukuwatari
    Department of Food Science and Nutrition, School of Human Cultures, The University of Shiga Prefecture, Hikone, Shiga 522 8533, Japan
    Nutr Res 29:839-45. 2009
    ..Physical characteristics and urine volume are less important for B-group vitamins except for vitamin B(12) as biomarker...
  43. ncbi request reprint Identification of a toxic mechanism of the plasticizers, phtahlic acid esters, which are putative endocrine disrupters: time-dependent increase in quinolinic acid and its metabolites in rats fed di(2-ethylhexyl)phthalate
    Tsutomu Fukuwatari
    Laboratory of Food Science and Nutrition, Department of Life Style Studies, School of Human Cultures, The University of Shiga Prefecture, Hikone, Shiga 522 8533, Japan
    Biosci Biotechnol Biochem 66:2687-91. 2002
    ..Feeding of DEHP, however, did not affect any enzyme activity including alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD), affecting the formation of QA, on the tryptophan-niacin pathway...
  44. ncbi request reprint Effect of fasting on the urinary excretion of water-soluble vitamins in humans and rats
    Tsutomu Fukuwatari
    Department of Food Science and Nutrition, School of Human Cultures, The University of Shiga Prefecture, Shiga, Japan
    J Nutr Sci Vitaminol (Tokyo) 56:19-26. 2010
    ..Our human study also suggested that the effect of fasting should be taken into consideration for subjects showing low urinary thiamin and high urinary riboflavin...
  45. ncbi request reprint Effects of fatty liver induced by niacin-free diet with orotic acid on the metabolism of tryptophan to niacin in rats
    Tsutomu Fukuwatari
    Department of Life Style Studies, School of Human Cultures, The University of Shiga Prefecture, Hikone, Japan
    Biosci Biotechnol Biochem 66:1196-204. 2002
    ..Therefore, the conversion ratio of tryptophan to niacin significantly decreased in the test group in comparison with the control group...
  46. ncbi request reprint Diurnal variations in human urinary excretion of nicotinamide catabolites: effects of stress on the metabolism of nicotinamide
    Hidemi Okamoto
    Course of Food Science and Nutrition, Department of Life Style Studies, School of Human Cultures, The University of Shiga Prefecture, Hikone, Shiga, Japan
    Am J Clin Nutr 77:406-10. 2003
    ..More than 500 enzymes need niacin coenzymes. Therefore, elucidation of the control mechanisms of coenzyme metabolism is fundamentally important...
  47. ncbi request reprint Effects of UVA irradiation on the concentration of folate in human blood
    Tsutomu Fukuwatari
    Department of Food Science and Nutrition, School of Human Cultures, The University of Shiga Prefecture, Hikone, Shiga, Japan
    Biosci Biotechnol Biochem 73:322-7. 2009
    ..These results suggest that UVA exposure destroyed PGA but not 5-methyltetrahydrofolate in human blood in vivo...
  48. ncbi request reprint Age-related alterations of B-group vitamin contents in urine, blood and liver from rats
    Tsutomu Fukuwatari
    Department of Food Science and Nutrition, School of Human Cultures, The University of Shiga Prefecture, Hikone, Shiga, Japan
    J Nutr Sci Vitaminol (Tokyo) 54:357-62. 2008
    ..Alteration of vitamin B6 metabolism in particular is similar to the observations in elderly humans reported previously. Our findings suggest that aged rats can be useful models to investigate aging-related B-group vitamin metabolism...
  49. ncbi request reprint [Metabolic disturbance of tryptophan-nicotinamide conversion pathway by putative endocrine disruptors, bisphenol A and styrene monomer]
    Tsutomu Fukuwatari
    Laboratories of Food Science and Nutrition, Department of Life Style Studies, School of Human Cultures, University of Shiga Prefecture 2500 Hassaka cho, Hikone 522 8533, Japan
    Shokuhin Eiseigaku Zasshi 45:1-7. 2004
    ..This is an FAD-enzyme and requires NADPH as a coenzyme. Styrene monomer (1% addition to a normal diet) did not affect the food intake or the body weight, but slightly reduced the conversion ratio of tryptophan-nicotinamide...
  50. ncbi request reprint [Action site of bisphenol A as metabolic disruptor lies in the tryptophan-nicotinamide conversion pathway]
    Tsutomu Fukuwatari
    Laboratory of Food Science, Department of Life Style Studies, School of Human Cultures, The University of Shiga Prefecture, 2500 Hassaka cho, Hikone 522 8533, Japan
    Shokuhin Eiseigaku Zasshi 45:231-8. 2004
    ..Namely, the conversion ratio of tryptophan to nicotinamide is reduced through the inhibition of kynurenine 3-hydroxylase activity by bisphenol A...
  51. ncbi request reprint The necessity of niacin in rats fed on a high protein diet
    Naoko Kimura
    Laboratories of Food Science and Nutrition, Department of Life Style Studies, School of Human Cultures, The University of Shiga Prefecture, Shiga, Japan
    Biosci Biotechnol Biochem 69:273-9. 2005
    ..The conversion ratio of tryptophan-niacin in rats fed on the 70% casein diet became extremely low, and then the rats needed niacin...
  52. ncbi request reprint Effects of excess nicotinamide administration on the urinary excretion of nicotinamide N-oxide and nicotinuric acid by rats
    Tsutomu Fukuwatari
    Laboratory of Food Science and Nutrition, Department of Life Style Studies, School of Human Cultures, The University of Shiga Prefecture, Hikone, Shiga, Japan
    Biosci Biotechnol Biochem 68:44-50. 2004
    ..These results show that the measurements of nicotinamide N-oxide and nicotinuric acid in urine would be useful indices for an excessive nicotinamide intake...
  53. ncbi request reprint Role of gustation in the recognition of oleate and triolein in anosmic rats
    Tsutomu Fukuwatari
    Department of Life Style Studies, School of Human Cultures, University of Shiga Prefecture, Hikone, Shiga 522 8533, Japan
    Physiol Behav 78:579-83. 2003
    ..The results suggest that rat recognizes oleate by a gustatory cue and that fatty acid but not triglyceride is important for gustatory recognition of fat...
  54. ncbi request reprint Effects of excess biotin administration on the growth and urinary excretion of water-soluble vitamins in young rats
    Hiromi Sawamura
    Laboratories of Food Science and Nutrition, Department of Life Style Studies, School of Human Cultures, The University of Shiga Prefecture, Hikone, Shiga, Japan
    Biosci Biotechnol Biochem 71:2977-84. 2007
    ..2 mg/kg body weight/day, while the no observed adverse effect level was 38.4 mg/kg/day. These results suggested immediately setting a tolerable upper intake level for biotin...
  55. ncbi request reprint Effect of nicotinamide administration on the tryptophan-nicotinamide pathway in humans
    Tsutomu Fukuwatari
    Laboratories of Food Science and Nutrition, Department of Life Style Studies, School of Human Cultures, The University of Shiga Prefecture, 2500 Hassaka, Hikone, Shiga 522 8533, Japan
    Int J Vitam Nutr Res 77:255-62. 2007
    ..Therefore, when niacin equivalent is calculated, the intake of nicotinamide itself need not be considered as a factor that changes the tryptophan-nicotinamide conversion ratio...
  56. ncbi request reprint The formation of nicotinamide by administration of di(2-ethylhexyl)phthalate does not cause growth retardation in young rats in contrast with excess exogenous administration of nicotinamide
    Tsutomu Fukuwatari
    Department of Food Science and Nutrition, School of Human Cultures, The University of Shiga Prefecture, Shiga, USA
    Biosci Biotechnol Biochem 72:2423-7. 2008
    ..Growth retardation of young rats due to DEHP was strengthened by increasing protein level. The addition of tryptophan to the diet caused extreme increases in the nicotinamide formation, but no growth retardation was observed...
  57. ncbi request reprint Urinary water-soluble vitamins and their metabolite contents as nutritional markers for evaluating vitamin intakes in young Japanese women
    Tsutomu Fukuwatari
    Department of Food Science and Nutrition, School of Human Cultures, The University of Shiga Prefecture, Hikone, Shiga, Japan
    J Nutr Sci Vitaminol (Tokyo) 54:223-9. 2008
    ..907 for folic acid, r=0.962 for biotin, and r=0.952 for vitamin C). These results suggest that measuring urinary water-soluble vitamins and their metabolite levels can be used as good nutritional markers for assessing vitamin intakes...
  58. ncbi request reprint [Establishment of animal model for elucidating the mechanism of intoxication by the poisonous mushroom Clitocybe acromelalga]
    T Fukuwatari
    Department of Life Style Studies, School of Human Cultures, University of Shiga Prefecture: 2500, Hassaka-cho, Hikone, Shiga 522-8533, Japan
    Shokuhin Eiseigaku Zasshi 42:185-9. 2001
    ..Since no similar symptom resembling human intoxication was seen in a previous rodent study, the niacin-free/tryptophan-limited diet used in the present study may have contributed to the result...
  59. ncbi request reprint Increase in conversion of tryptophan to niacin in pregnant rats
    Katsumi Shibata
    Laboratories of Food Science and Nutrition, Department of Life Style Studies, School of Human Cultures, The University of Shiga Prefecture, Hikone, Shiga 522 8533, Japan
    Adv Exp Med Biol 527:435-41. 2003
    ..The catabolism of tryptophan is accelerated during pregnancy, indicataing that pregnancy would not be an etiology of pellagra and no niacin supplement needs but tryptohan supplement would need...
  60. ncbi request reprint Changes in the urinary excretion of the metabolites of the tryptophan-niacin pathway during pregnancy in Japanese women and rats
    Tsutomu Ftukijwatari
    Laboratories of Food Science and Nutrition, Department of Lift Style Studies, School of Human Cultlures, The University of Shiga Prefecture, Hikone, Japan
    J Nutr Sci Vitaminol (Tokyo) 50:392-8. 2004
    ..The urinary excretions of niacin metabolites in humans and rats increased from mid pregnancy in a time-dependent manner, reached a peak of 2-3-fold during late pregnancy, and declined to control levels after childbirth...
  61. doi request reprint Fluorometric determination of pantothenic acid in human urine by isocratic reversed-phase ion-pair high-performance liquid chromatography with post-column derivatization
    Kei Takahashi
    Department of Food Science and Nutrition, School of Human Cultures, The University of Shiga Prefecture, 2500 Hassaka, Hikone, Shiga 522 8533, Japan
    J Chromatogr B Analyt Technol Biomed Life Sci 877:2168-72. 2009
    ..The total time required for the analysis was ca. 25 min. The proposed method can be used to assess the pantothenic acid content of human urine as an alternative to the standard microbioassay for pantothenic acid...
  62. pmc Purification and molecular cloning of rat 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
    Atsushi Tanabe
    Graduate School of Science and Technology, Chiba University, 648 Matsudo, Matsudo, Chiba 271 8510, Japan
    Biochem J 361:567-75. 2002
    ..The distribution of ACMSD mRNA expression in various tissues was investigated in the rat by RT-PCR. ACMSD was expressed in the liver and kidney, but not in the other principal organs examined...
  63. ncbi request reprint Identification and expression of alpha cDNA encoding human 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase (ACMSD): a key enzyme for the tryptophan-niacine pathway and quinolinate hypothesis
    Shin Ichi Fukuoka
    Graduate School of Agriculuture, Kyoto University, Uji, Kyoto 611 0011, Japan
    Adv Exp Med Biol 527:443-53. 2003
    ..This suggests that a pathway does exist by which the levels of quinolinate in the brain are regulated. In this report, we address the molecular basis underlying quinolinate metabolism and the regulation of ACMSD expression...
  64. ncbi request reprint Tryptophan metabolism was accelerated by exercise in rat
    Yasuhiro Ito
    Department of Physiology, School of Health Sciences, Fujita Health University, Toyoake Aichi, 470 1192, Japan
    Adv Exp Med Biol 527:531-5. 2003
    ..Tryptophan-NAD pathway was initiated by cleavage of indole ring of tryptophan by TDO in the liver and IDO in many organs. We had also found that the exercise increase IDO activity of macrophages, but not TDO activity...
  65. ncbi request reprint Expression of rat hepatic 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase is affected by a high protein diet and by streptozotocin-induced diabetes
    Atsushi Tanabe
    Graduate School of Science and Technology, Chiba University, 648 Matsudo, Chiba 271 8510, Japan
    J Nutr 132:1153-9. 2002
    ..These results indicated that the fluctuation of hepatic ACMSD mRNA expression was followed by that of ACMSD activity...
  66. ncbi request reprint Identification and expression of a cDNA encoding human alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD). A key enzyme for the tryptophan-niacine pathway and "quinolinate hypothesis"
    Shin Ichi Fukuoka
    Graduate School of Agriculture, Kyoto University, Uji, Kyoto 611 0011, Japan
    J Biol Chem 277:35162-7. 2002
    ..This suggests that a pathway does exist by which the levels of quinolinate in the brain are regulated. In this report, we address the molecular basis underlying quinolinate metabolism and the regulation of ACMSD expression...
  67. ncbi request reprint Sensitivity and specificity of published strategies using urinary creatinine to identify incomplete 24-h urine collection
    Kentaro Murakami
    Nutritional Epidemiology Program, National Institute of Health and Nutrition, Tokyo, Japan
    Nutrition 24:16-22. 2008
    ..We examined the sensitivity and specificity of several strategies that use creatinine to identify incomplete urine using the p-aminobenzoic acid (PABA) check method as reference...
  68. ncbi request reprint Nicotinamide suppresses hyperphosphatemia in hemodialysis patients
    Yutaka Takahashi
    Department of Medicine, Koto Hospital, Tokyo, Japan
    Kidney Int 65:1099-104. 2004
    ....
  69. doi request reprint Dietary glycemic index is associated with decreased premenstrual symptoms in young Japanese women
    Kentaro Murakami
    Department of Social and Preventive Epidemiology, School of Public Health, University of Tokyo, Tokyo, Japan
    Nutrition 24:554-61. 2008
    ..In this observational cross-sectional study, we investigated associations between dietary GI and other dietary carbohydrates and premenstrual symptoms...
  70. ncbi request reprint Transforming growth factor-beta in the brain is activated by exercise and increases mobilization of fat-related energy substrates in rats
    Tetsuro Shibakusa
    Laboratory of Nutrition Chemistry, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto Univ, Kitashirakawa, Sakyo, Kyoto, Japan
    Am J Physiol Regul Integr Comp Physiol 292:R1851-61. 2007
    ..We hypothesized that the central nervous system plays a role in the regulation of energy metabolism during low-intensity exercise and this may be mediated by TGF-beta...
  71. pmc Relationship between soy and isoflavone intake and periodontal disease: the Freshmen in Dietetic Courses Study II
    Keiko Tanaka
    Department of Public Health, Faculty of Medicine, Fukuoka University, Fukuoka, Japan
    BMC Public Health 8:39. 2008
    ..The aim of this study was to investigate whether soy and isoflavone intake is associated with the prevalence of periodontal disease...