Research Topics
Genomes and Genes | Tetsuro OhmoriSummaryAffiliation: The University of Tokushima Country: Japan Publications
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Publications
Gene expression and association analysis of the epithelial membrane protein 1 gene in major depressive disorder in the Japanese populationMasahito Nakataki
Department of Psychiatry, Course of Integrated Brain Sciences, Medical Informatics, Institute of Health Biosciences, The University of Tokushima Graduate School, 18 15 Kuramoto cho 3, Tokushima 770 8509, Japan
Neurosci Lett 489:126-30. 2011..039). Our results suggest that the EMP1 gene may be implicated in the pathophysiology of MDD in the Japanese population...
Association between PNPO and schizophrenia in the Japanese populationHongwei Song
Department of Psychiatry, Course of Integrated Brain Sciences, Medical Informatics, Institute of Health Biosciences, The University of Tokushima Graduate School, Japan
Schizophr Res 97:264-70. 2007..00001) between PNPO and schizophrenia. These findings suggest that variations in PNPO may contribute to overall genetic risk for schizophrenia in the Japanese population...- Gene expression and association analyses of the phosphodiesterase 4B (PDE4B) gene in major depressive disorder in the Japanese populationShusuke Numata
Department of Psychiatry, Course of Integrated Brain Sciences, Medical Informatics, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
Am J Med Genet B Neuropsychiatr Genet 150:527-34. 2009..Our results suggest that the PDE4B gene itself does not link to MDD but the elevated mRNA levels of PDE4B might be implicated in the pathophysiology of MDD... - TGFBR2 gene expression and genetic association with schizophreniaShusuke Numata
Department of Psychiatry, Course of Integrated Brain Sciences, Medical Informatics, Institute of Health Biosciences, The University of Tokushima Graduate School, 3 8 15 Kuramoto cho Tokushima 770 8503, Japan
J Psychiatr Res 42:425-32. 2008..Our results suggest that the TGFBR2 gene itself does not link to schizophrenia but that the TGFBR2 mRNA levels in the peripheral leukocytes may be a potential state marker for schizophrenia... - Positive association of the PDE4B (phosphodiesterase 4B) gene with schizophrenia in the Japanese populationShusuke Numata
Department of Psychiatry, Course of Integrated Brain Sciences, Medical Informatics, Institute of Health Biosciences, The University of Tokushima Graduate School, Japan
J Psychiatr Res 43:7-12. 2008..001). Our result suggests that variations at the PDE4B locus may play a significant role in the etiology of SZ in the Japanese population... - Gene expression in the peripheral leukocytes and association analysis of PDLIM5 gene in schizophreniaShusuke Numata
Department of Psychiatry, Course of Integrated Brain Sciences, Medical Informatics, Institute of Health Biosciences, The University of Tokushima Graduate School, 3 8 15 Kuramoto cho, Tokushima 770 8503, Japan
Neurosci Lett 415:28-33. 2007..48), either. We suggest that the higher expression levels of the PDLIM5 mRNA in the peripheral leukocytes may be a candidate marker for medication-free schizophrenic patients... - The Val66Met polymorphism of the brain-derived neurotrophic factor gene is associated with psychotic feature and suicidal behavior in Japanese major depressive patientsJun Ichi Iga
Department of Psychiatry, Course of Integrated Brain Sciences, Medical Informatics, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
Am J Med Genet B Neuropsychiatr Genet 144:1003-6. 2007..These results suggest that the BDNF Val66Met polymorphism is not related to the development of MDD but related to clinical features of MDD in a Japanese population... - Metabolite changes and gender differences in schizophrenia using 3-Tesla proton magnetic resonance spectroscopy (1H-MRS)Shin Ya Tayoshi
Department of Psychiatry, Course of Integrated Brain Sciences, Medical Informatics, Institute of Health Biosciences, University of Tokushima Graduate School, Japan
Schizophr Res 108:69-77. 2009..These results confirmed a change in the glutamatergic system and suggested an involvement of mI in the pathophysiology of schizophrenia... 
Positive association of the pericentrin (PCNT) gene with major depressive disorder in the Japanese populationShusuke Numata
Department of Psychiatry, Course of Integrated Brain Sciences, Medical Informatics, Institute of Health Biosciences, The University of Tokushima Graduate School, 3 8 15 Kuramoto cho, Tokushima 770 8503, Japan
J Psychiatry Neurosci 34:195-8. 2009..Pericentrin (PCNT) interacts with disruption-in-schizophrenia 1 (DISC1), a known genetic risk factor for schizophrenia, bipolar disorder and major depressive disorder (MDD). We sought to determine whether the PCNT gene is implicated in MDD...- The chitinase 3-like 1 gene and schizophrenia: evidence from a multi-center case-control study and meta-analysisKazutaka Ohi
Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
Schizophr Res 116:126-32. 2010..003). We conclude that the genetic variants in the CHI3L1 gene have ethnic heterogeneity and confer a susceptibility to schizophrenia in Asian populations... - [Clinical features of patients with obsessive-compulsive disorder showing different pharmacological responses]Satsuki Sumitani
Department of Psychiatry, Institute of Health Biosciences, University of Tokushima Graduate School
Seishin Shinkeigaku Zasshi 108:1282-92. 2006..However, there are patients who still show no response after trials with this augmentation therapy. In the present study, we examined the clinical features of OCD patients who showed different responses to pharmacological treatment... - Gene expression and association analysis of vascular endothelial growth factor in major depressive disorderJun Ichi Iga
Department of Psychiatry, Course of Integrated Brain Sciences, Medical Informatics, Institute of Health Biosciences, The University of Tokushima Graduate School, 3 18 15 Kuramoto, Tokushima 770 8503, Japan
Prog Neuropsychopharmacol Biol Psychiatry 31:658-63. 2007..Our investigation indicates that the higher expression levels of VEGF mRNA in the peripheral leukocytes are associated with the depressive state and their recovery after treatment may be associated with the clinical improvement... - Subjective and objective quality of life, levels of life skills, and their clinical determinants in outpatients with schizophreniaHirofumi Aki
Department of Psychiatry, Institute of Health Biosciences, The University of Tokushima Graduate School, 3 18 15 Kuramoto cho, Tokushima, Tokushima 770 8503, Japan
Psychiatry Res 158:19-25. 2008.... - GABA concentration in schizophrenia patients and the effects of antipsychotic medication: a proton magnetic resonance spectroscopy studyShin Ya Tayoshi
Department of Psychiatry, Course of Integrated Brain Sciences, Medical Informatics, Institute of Health Biosciences, The University of Tokushima Graduate School, Japan
Schizophr Res 117:83-91. 2010..It is possible that medication effects conceal inherent differences in GABA concentrations between schizophrenia patients and healthy controls... - Activation of the prefrontal cortex during the Trail-Making Test detected with multichannel near-infrared spectroscopySumiko Shibuya-Tayoshi
Department of Psychiatry, Course of Integrated Brain Sciences, Institute of Health Bioscience, University of Tokushima Graduate School, Tokushima, Japan
Psychiatry Clin Neurosci 61:616-21. 2007..NIRS detected activation in the PFC during the performance of the TMT Part B and this PFC activation may reflect executive functions including cognitive set shifting involved in the TMT Part B... - Quality of life and cognitive dysfunction in people with schizophreniaYoshinori Ueoka
Department of Psychiatry, Institute of Health Bioscience, The University of Tokushima Graduate School, Japan
Prog Neuropsychopharmacol Biol Psychiatry 35:53-9. 2011..The results suggest that negative and depressive symptoms are important factors on patients' QOL and also support the view that cognitive performance provides a determinant of QOL in patients with schizophrenia... - Subjective and objective measures of quality of life have different predictors for people with schizophreniaMasahito Tomotake
Department of Psychiatry, Institute of Health Biosciences, The University of Tokushima Graduate School, 3 18 15, Kuramoto Cho, Tokushimashi, Tokushima 770 8503, Japan
Psychol Rep 99:477-87. 2006..These results suggest that subjective and objective quality of life have different predictors and should be considered as separate and complementary outcome variables... - Altered HDAC5 and CREB mRNA expressions in the peripheral leukocytes of major depressionJun Ichi Iga
Department of Psychiatry, Course of Integrated Brain Sciences, University of Tokushima School of Medicine, Tokushima 770 8503, Japan
Prog Neuropsychopharmacol Biol Psychiatry 31:628-32. 2007..HDAC5 and CREB are reported to be important targets of antidepressants, the latter being located in the downstream of the former in lymphocyte calcium signaling... - Association study between the pericentrin (PCNT) gene and schizophreniaShusuke Numata
Department of Psychiatry, Course of Integrated Brain Sciences, Medical Informatics, Institute of Health Biosciences, The University of Tokushima Graduate School, Kuramoto Cho, Tokushima, Japan
Neuromolecular Med 12:243-7. 2010..In the haplotypic analysis, we could not find any significant association in our subjects, either. This gene may not play a major role independently in the etiology of SZ in the Japanese population... - Gene expression and association analysis of LIM (PDLIM5) in major depressionJun Ichi Iga
Department of Psychiatry, Course of Integrated Brain Sciences, Medical Informatics, Institute of Health Biosciences, The University of Tokushima Graduate School, 3 18 15 Kuramoto, Tokushima 770 8503, Japan
Neurosci Lett 400:203-7. 2006..Our investigation indicates that the lower expression levels of LIM mRNA in the peripheral leukocytes are associated with the depressive state and that its recovery after treatment may be an adaptive change induced by the antidepressant... - Predictors of subjective and objective quality of life in outpatients with schizophreniaKen Yamauchi
Department of Psychiatry, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan
Psychiatry Clin Neurosci 62:404-11. 2008..Particular attention was paid to cognitive function as a predictor of QOL... - FKBP5, SERT and COMT mRNA expressions in the peripheral leukocytes during menstruation cycle in healthy reproductive femalesSawako Kinouchi
Department of Psychiatry, Institute of Health Biosciences, The University of Tokushima Graduate School, 3 18 15 Kuramoto cho, Tokushima 770 8503, Japan
Neurosci Lett 434:124-8. 2008..In conclusion, there are differences of HADS anxiety score and FKBP5 mRNA expression in the leukocytes across the menstrual cycle but there is no correlation between anxiety scores and FKBP5 mRNA... - Lithium decreases VEGF mRNA expression in leukocytes of healthy subjects and patients with bipolar disorderKumiko Kikuchi
Department of Psychiatry, Course of Integrated Brain Sciences, University of Tokushima School of Medicine, Tokushima, Japan
Hum Psychopharmacol 26:358-63. 2011..The aim of this study was to elucidate molecular effects of lithium on VEGF expression by using leukocytes of healthy subjects and patients with bipolar disorder... - Functional genetic variation at the NRGN gene and schizophrenia: evidence from a gene-based case-control study and gene expression analysisKazutaka Ohi
Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
Am J Med Genet B Neuropsychiatr Genet 159:405-13. 2012.... - Activation of the prefrontal cortex during the Wisconsin Card Sorting Test as measured by multichannel near-infrared spectroscopySatsuki Sumitani
Department of Psychiatry, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan
Neuropsychobiology 53:70-6. 2006..However, inconsistent results have been reported concerning whether this task activates the PFC symmetrically or asymmetrically... - Molecular assessment of depression from mRNAs in the peripheral leukocytesJun Ichi Iga
Department of Psychiatry, Course of Integrated Brain Sciences, Medical Informatics, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
Ann Med 40:336-42. 2008..In this paper, we review the studies on the leukocyte gene expression, including our own, and discuss the limitations and strengths of the current gene expression-based molecular assessment of depression by the leukocyte mRNA expression... - Impact of a switch from typical to atypical antipsychotic drugs on quality of life and gonadal hormones in male patients with schizophreniaYasuhiro Kaneda
Department of Psychiatry, Tokushima University Hospital, Tokushima, Japan
Neuro Endocrinol Lett 25:135-40. 2004..We investigated the effects of a switch from typical to atypical antipsychotic drugs (olanzapine, n=8; perospirone, n=9; or quetiapine, n=13) on quality of life and hypothalamo-pituitary-gonadal axis hormones... - Changes in circulating cytokine levels in midlife women with psychological symptoms with selective serotonin reuptake inhibitor and Japanese traditional medicineToshiyuki Yasui
Department of Obstetrics and Gynecology, Course of Human Development, Human Development and Health Science, The University of Tokushima Graduate School, 3 18 15 Kuramoto, Tokushima 770 8503, Japan
Maturitas 62:146-52. 2009.... - Lithium effects on brain glutamatergic and GABAergic systems of healthy volunteers as measured by proton magnetic resonance spectroscopySumiko Shibuya-Tayoshi
Department of Psychiatry, Course of Integrated Brain Sciences, Institute of Health Bioscience, The University of Tokushima Graduate School, 3 18 15 Kuramoto, Tokushima 770 8503, Japan
Prog Neuropsychopharmacol Biol Psychiatry 32:249-56. 2008..Our finding might suggest that the decrease of Glx levels is associated with the pharmacological actions of subchronic lithium treatment... - Multi-channel near-infrared spectroscopy reveals reduced prefrontal activation in schizophrenia patients during performance of the kana Stroop taskKyoko Taniguchi
Department of Psychiatry, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
J Med Invest 59:45-52. 2012.... - [Schizophrenia Cognition Rating Scale Japanese version (SCoRS-J) as a co-primary measure assessing cognitive function in schizophrenia]Yasuhiro Kaneda
Department of Psychiatry, Iwaki Clinic, Tokushima, Japan
Nihon Shinkei Seishin Yakurigaku Zasshi 31:259-62. 2011..For its clinical application, we developed the Japanese-language version of the SCoRS (SCoRS-J) and UPSA (UPSA-J) through back-translation into English... - Brief assessment of cognition in schizophrenia: validation of the Japanese versionYasuhiro Kaneda
Department of Psychiatry, Tokushima University Hospital, Tokushima, Japan
Psychiatry Clin Neurosci 61:602-9. 2007..This preliminary study indicates that the BACS-J is a reliable and practical scale to evaluate cognitive function... - Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism in schizophrenia is associated with age at onset and symptomsShusuke Numata
Department of Psychiatry, Course of Integrated Brain Sciences, Medical Informatics, Institute of Health Biosciences, The University of Tokushima Graduate School, 3 8 15 Kuramoto cho, Tokushima 770 8503, Japan
Neurosci Lett 401:1-5. 2006..21). Our investigation indicates that the BDNF gene Val66Met polymorphism is related to the onset age of schizophrenia and the levels of clinical symptoms that remain after long-term antipsychotic treatment... - Association study of the G72 gene with schizophrenia in a Japanese population: a multicenter studyKazutaka Ohi
Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
Schizophr Res 109:80-5. 2009..However, these associations were no longer positive after correction for multiple testing. We conclude that G72 might not play a major role in the risk for schizophrenia in the Japanese population... - Association Study of Fat-mass and Obesity-associated Gene and Body Mass Index in Japanese Patients with Schizophrenia and Healthy SubjectsShin Ya Watanabe
Department of Psychiatry, Course of Integrated Brain Sciences, University of Tokushima School of Medicine, Tokushima, Japan
Clin Psychopharmacol Neurosci 10:185-9. 2012..The aim of this study is to elucidate effects of FTO gene polymorphism on BMI in Japanese patients with schizophrenia and healthy subjects... - Multi-channel near-infrared spectroscopy shows reduced activation in the prefrontal cortex during facial expression processing in pervasive developmental disorderYoshihiro Nakadoi
Department of Psychiatry, Course of Integrated Brain Sciences, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan
Psychiatry Clin Neurosci 66:26-33. 2012.... - Proton magnetic resonance spectroscopy reveals an abnormality in the anterior cingulate of a subgroup of obsessive-compulsive disorder patientsSatsuki Sumitani
Department of Psychiatry, Institute of Health Biosciences, University of Tokushima Graduate School, 18 15 Kuramoto cho 3, Tokushima 770 8503, Japan
Psychiatry Res 154:85-92. 2007..Our results suggest that a subgroup of OCD patients who respond to an SSRI with an atypical antipsychotic have distinct biological abnormalities in the anterior cingulate... - Correlation between plasma homovanillic acid levels and the response to atypical antipsychotics in male patients with schizophreniaYasuhiro Kaneda
Department of Psychiatry, Tokushima University Hospital, 3 18 15 Kuramoto cho, Tokushima, Tokushima 770 8503, Japan
Clin Neuropharmacol 28:262-4. 2005..The authors investigated the effects of atypical antipsychotic drugs-olanzapine, perospirone, and quetiapine-on plasma homovanillic acid (pHVA) in male patients with chronic schizophrenia... - Effect of antipsychotic replacement with quetiapine on the symptoms and quality of life of schizophrenic patients with extrapyramidal symptomsTakahide Taniguchi
Department of Psychiatry, University of Tokushima School of Medicine, Tokushima City, Tokushima, Japan
Hum Psychopharmacol 21:439-45. 2006..4 +/- 4.3 mg/day) of previous drugs (n = 11). The results suggest that replacement with QTP improves symptoms as well as objective and subjective QOL in a subgroup of schizophrenia... - Association of serum cytokine concentrations with psychological symptoms in midlife womenToshiyuki Yasui
Department of Obstetrics and Gynecology, Course of Human Development, Human Development and Health Science, Institute of Health Biosciences, The University of Tokushima Graduate School, Kuramoto, Tokushima, Japan
J Reprod Immunol 75:56-62. 2007..The purpose of the present study was to clarify the association of serum cytokine concentrations, determined using a multiplexed cytokine assay, with psychological symptoms in midlife women... - The hypothalamic-pituitary-adrenal axis in chronic schizophrenic patients long-term treated with neurolepticsYasuhiro Kaneda
Department of Neuropsychiatry, University of Tokushima School of Medicine, 3 18 15 Kuramoto cho, Tokushima 770 8503, Japan
Prog Neuropsychopharmacol Biol Psychiatry 26:935-8. 2002..The authors investigated the hypothalamic-pituitary-adrenal (HPA) axis of regularly medicated schizophrenic patients... - Clock mutant mice with Jcl/ICR background shows an impaired learning ability in water maze, but not in passive avoidance, at the beginning of dark phaseHiroyoshi Sei
Department of Integrative Physiology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
Congenit Anom (Kyoto) 46:81-5. 2006..Clock, an essential gene controlling circadian rhythm, may have an important role on the spatial learning and hippocampal cholinergic function, at least, at the beginning of the dark phase... - Schizophrenia Quality of Life Scale: validation of the Japanese versionYasuhiro Kaneda
Department of Neuropsychiatry, University of Tokushima School of Medicine, 3 18 15, Kuramoto Cho, Tokushima, Tokushima 770 8503, Japan
Psychiatry Res 113:107-13. 2002..There were associations with relevant SF-36, WHO QOL-26, and DIEPSS scores. From the results of the testing of the reliability and validity of the JSQLS, it is concluded that the JSQLS is a simple and reliable scale... - Repetitive behaviors in chronic schizophrenia: using the Japanese version of the Elgin Behavior Rating Scale (JEBRS)Yasuhiro Kaneda
Psychopharmacology Division, Psychiatric Hospital at Vanderbilt, Nashville, Tennessee 37212, USA
Int J Neurosci 113:879-90. 2003..The total score for nine repetitive behaviors in the JEBRS was positively correlated with positive and negative symptoms. This study showed that the JEBRS is a useful and reliable scale... - Effects of quetiapine on gonadal axis hormones in male patients with schizophrenia: a preliminary, open studyYasuhiro Kaneda
Psychopharmacology Division, Psychiatric Hospital at Vanderbilt, 1601 23rd Avenue South, Suite 306, Nashville, TN 37212, USA
Prog Neuropsychopharmacol Biol Psychiatry 27:875-8. 2003..The authors investigated the effects of a novel antipsychotic agent, quetiapine administration on hypothalamo-pituitary-gonadal (HPG) axis hormones in patients with chronic schizophrenia... - Temperament, character, and eating attitudes in Japanese college womenMasahito Tomotake
Department of Psychiatry, The University of Tokushima School of Medicine, Tokushima shi, Japan
Psychol Rep 92:1162-8. 2003..43, p = .0001). The present results suggest that Japanese college women who score high on Harm Avoidance and low on Self-directedness may be more likely to develop inappropriate eating attitudes... - Impact of risperidone medication on quality of life and gonadal axis hormones in schizophrenia male patients with acute exacerbationYasuhiro Kaneda
Psychopharmacology Division, Psychiatric Hospital at Vanderbilt, Nashville, TN 37212, USA
Int J Neuropsychopharmacol 6:247-52. 2003..Our findings suggested that risperidone might improve psychosocial and motivation/energy QoL subscales, and increase prolactin without affecting the HPG axis hormones... - Left atrial thrombosis associated with antipsychotic drugsShusuke Numata
Department of Psychiatry, The University of Tokushima School of Medicine, 3 8 15 Kuramoto cho, Tokushima 770 8503, Japan
Prog Neuropsychopharmacol Biol Psychiatry 29:153-5. 2005..There have been small number of case reports of antipsychotic drugs-associated thromboembolic events. All of them are venous ones. This paper describes the first case of atrial thrombosis associated with antipsychotic drugs... - DNA methylation signatures of peripheral leukocytes in schizophreniaMakoto Kinoshita
Department of Psychiatry, Course of Integrated Brain Sciences, Medical Informatics, Institute of Health Biosciences, The University of Tokushima Graduate School, 3 8 15 Kuramoto cho, Tokushima, 770 8503, Japan
Neuromolecular Med 15:95-101. 2013..These findings support the notion that altered DNA methylation could be involved in the pathophysiology of SCZ... - [Two cases of tardive Tourette syndrome]Ken Yamauchi
Department of Psychiatry, Course of Integrated Brain Science, Medical Informatic, Institute of Health Biosciences, The University of Tokushima Graduate School
Seishin Shinkeigaku Zasshi 108:459-65. 2006..Tardive Tourette syndrome should not be misdiagnosed as an exacerbation of schizophrenic symptoms responsive to an increase of neuroleptics. This side effect should be recognized widely and treated properly... - Assessment of human stress and depression by DNA microarray analysisTetsuro Ohmori
Department of Psychiatry, The University of Tokushima Graduate School, Japan
J Med Invest 52:266-71. 2005..This microarray enabled us to sensitively detect the response to psychological stress. In addition, our preliminary study suggests that the array could differentiate patients with depression from sex- and age-matched control subjects... - Serotonin transporter mRNA expression in peripheral leukocytes of patients with major depression before and after treatment with paroxetineJun Ichi Iga
Department of Psychiatry, Course of Integrated Brain Sciences, The University of Tokushima School of Medicine, 3 18 15 Kuramoto cho, Tokushima 770 8503, Japan
Neurosci Lett 389:12-6. 2005.... - Hemodynamic changes in the prefrontal cortex during mental works as measured by multi channel near-infrared spectroscopy (NIRS)Satsuki Sumitani
Department of Psychiatry, Institute of Health Biosciences, The University of Tokushima Graduate School, Japan
J Med Invest 52:302-3. 2005..It was directly confirmed that the PFC was activated during mental tasks in vivo and it was suggested that distribution of the activation in the PFC is different among healthy individuals... - Stress control and human nutritionEiji Takeda
Department of Clinical Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
J Med Invest 51:139-45. 2004..Therefore, it is concluded that the establishment of functional foods that correctly regulate stress response must be firmly based upon scientific knowledge and legal regulation... - Expression analysis of psychological stress-associated genes in peripheral blood leukocytesKyoko Morita
Department of Stress Science, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan
Neurosci Lett 381:57-62. 2005..Our results suggest that gene expression profile in peripheral blood leukocytes may be a potentially useful method for the assessment of complex stress responses...