Akihiro Noda

Summary

Affiliation: The Medical and Pharmacological Research Center Foundation
Country: Japan

Publications

  1. ncbi request reprint Age-related changes in cerebral blood flow and glucose metabolism in conscious rhesus monkeys
    Akihiro Noda
    Advanced Technology Platform Research Laboratory, Fujisawa Pharmaceutical Co Ltd, Ibaraki 300 2698, Japan
    Brain Res 936:76-81. 2002
  2. ncbi request reprint Measurement of brain concentration of FK960 for development of a novel antidementia drug: a PET study in conscious rhesus monkeys
    Akihiro Noda
    The Medical and Pharmacological Research Center Foundation, Hakui, Japan
    J Nucl Med 44:105-8. 2003
  3. ncbi request reprint Effect of N-(4-Acetyl-1-piperazinyl)-p-fluorobenzamide monohydrate (FK960), an antidementia drug with a novel mechanism of action, on regional cerebral blood flow and glucose metabolism in aged rhesus macaques studied with positron emission tomography
    Akihiro Noda
    Advanced Technology Platform Research Laboratory, Fuijsawa Pharmaceutical Co, Ltd Ibaraki, Japan
    J Pharmacol Exp Ther 306:213-7. 2003
  4. doi request reprint Amyloid imaging in aged and young macaques with [11C]PIB and [18F]FDDNP
    Akihiro Noda
    Basic Research Division, The Medical and Pharmacological Research Center Foundation, Hakui, Japan
    Synapse 62:472-5. 2008
  5. ncbi request reprint Determination of kinetic rate constants for 2-[18F]fluoro-2-deoxy-D-glucose and partition coefficient of water in conscious macaques and alterations in aging or anesthesia examined on parametric images with an anatomic standardization technique
    Akihiro Noda
    Department of Biotracer Medicine, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan
    J Cereb Blood Flow Metab 23:1441-7. 2003
  6. doi request reprint Donepezil- and scopolamine-induced rCMRglu changes assessed by PET in conscious rhesus monkeys
    Makoto Asai
    The Medical and Pharmacological Research Center Foundation, Hakui, Ishikawa, Japan
    Ann Nucl Med 23:877-82. 2009
  7. ncbi request reprint 18F-labelled annexin V: a PET tracer for apoptosis imaging
    Yoshihiro Murakami
    The Medical and Pharmacological Research Center Foundation, Wo32, 925 0613, Inoyama, Hakui, Ishikawa, Japan
    Eur J Nucl Med Mol Imaging 31:469-74. 2004
  8. ncbi request reprint Synthesis and evaluation of [11C]FR194921 as a nonxanthine-type PET tracer for adenosine A1 receptors in the brain
    Takahiro Matsuya
    Basic Research Division, The Medical and Pharmacological Research Center Foundation, Ishikawa 925 0613, Japan
    Nucl Med Biol 32:837-44. 2005
  9. ncbi request reprint A PET study following treatment with a pharmacological stressor, FG7142, in conscious rhesus monkeys
    Hiroyuki Takamatsu
    The Medical and Pharmacological Research Center Foundation, Wo32, Inoyama Town, Hakui City, Ishikawa 925 0613, Japan
    Brain Res 980:275-80. 2003
  10. doi request reprint Cancer detection using a PET tracer, 11C-glycylsarcosine, targeted to H+/peptide transporter
    Keisuke Mitsuoka
    Graduate School of Natural Science and Technology, Kanazawa University, Kakuma machi, Kanazawa, Ishikawa, Japan
    J Nucl Med 49:615-22. 2008

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Age-related changes in cerebral blood flow and glucose metabolism in conscious rhesus monkeys
    Akihiro Noda
    Advanced Technology Platform Research Laboratory, Fujisawa Pharmaceutical Co Ltd, Ibaraki 300 2698, Japan
    Brain Res 936:76-81. 2002
    ..These results demonstrated the potential of aged monkeys to serve as an aged human model using PET...
  2. ncbi request reprint Measurement of brain concentration of FK960 for development of a novel antidementia drug: a PET study in conscious rhesus monkeys
    Akihiro Noda
    The Medical and Pharmacological Research Center Foundation, Hakui, Japan
    J Nucl Med 44:105-8. 2003
    ..This study used PET to measure the time course of the brain concentration of (18)F-labeled N-(4-acetyl-1-piperazinyl)-p-fluorobenzamide monohydrate (FK960), a novel antidementia drug, after oral administration to conscious rhesus monkeys...
  3. ncbi request reprint Effect of N-(4-Acetyl-1-piperazinyl)-p-fluorobenzamide monohydrate (FK960), an antidementia drug with a novel mechanism of action, on regional cerebral blood flow and glucose metabolism in aged rhesus macaques studied with positron emission tomography
    Akihiro Noda
    Advanced Technology Platform Research Laboratory, Fuijsawa Pharmaceutical Co, Ltd Ibaraki, Japan
    J Pharmacol Exp Ther 306:213-7. 2003
    ..01 or 0.1 mg/kg. These results suggested that FK960 restored the rCBF and rCMRglc deficits in brain areas responsible for cognitive functioning in aged rhesus macaques...
  4. doi request reprint Amyloid imaging in aged and young macaques with [11C]PIB and [18F]FDDNP
    Akihiro Noda
    Basic Research Division, The Medical and Pharmacological Research Center Foundation, Hakui, Japan
    Synapse 62:472-5. 2008
    ..Although [18F]FDDNP may have possible usefulness for imaging, including other proteins, [11C]PIB may be better for amyloid imaging owing to lower non-specific binding...
  5. ncbi request reprint Determination of kinetic rate constants for 2-[18F]fluoro-2-deoxy-D-glucose and partition coefficient of water in conscious macaques and alterations in aging or anesthesia examined on parametric images with an anatomic standardization technique
    Akihiro Noda
    Department of Biotracer Medicine, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan
    J Cereb Blood Flow Metab 23:1441-7. 2003
    ..The occipital cortex was also the most affected region. The tissue-blood partition coefficient of water was decreased globally...
  6. doi request reprint Donepezil- and scopolamine-induced rCMRglu changes assessed by PET in conscious rhesus monkeys
    Makoto Asai
    The Medical and Pharmacological Research Center Foundation, Hakui, Ishikawa, Japan
    Ann Nucl Med 23:877-82. 2009
    ..We aimed to characterize the effects of donepezil on rCMRglu using FDG-PET in non-human primates...
  7. ncbi request reprint 18F-labelled annexin V: a PET tracer for apoptosis imaging
    Yoshihiro Murakami
    The Medical and Pharmacological Research Center Foundation, Wo32, 925 0613, Inoyama, Hakui, Ishikawa, Japan
    Eur J Nucl Med Mol Imaging 31:469-74. 2004
    ..The low uptake of [18F]annexin V in these organs might represent an advantage over [(99m)Tc]annexin V...
  8. ncbi request reprint Synthesis and evaluation of [11C]FR194921 as a nonxanthine-type PET tracer for adenosine A1 receptors in the brain
    Takahiro Matsuya
    Basic Research Division, The Medical and Pharmacological Research Center Foundation, Ishikawa 925 0613, Japan
    Nucl Med Biol 32:837-44. 2005
    ..These results suggest that [11C]FR194921 can be used as an agent for imaging adenosine A1 receptors in vivo by positron emission tomography (PET)...
  9. ncbi request reprint A PET study following treatment with a pharmacological stressor, FG7142, in conscious rhesus monkeys
    Hiroyuki Takamatsu
    The Medical and Pharmacological Research Center Foundation, Wo32, Inoyama Town, Hakui City, Ishikawa 925 0613, Japan
    Brain Res 980:275-80. 2003
    ....
  10. doi request reprint Cancer detection using a PET tracer, 11C-glycylsarcosine, targeted to H+/peptide transporter
    Keisuke Mitsuoka
    Graduate School of Natural Science and Technology, Kanazawa University, Kakuma machi, Kanazawa, Ishikawa, Japan
    J Nucl Med 49:615-22. 2008
    ..We also compared the tracer with 18F-FDG, focusing on the specificity of their accumulation between tumor and inflammatory tissues...
  11. ncbi request reprint Rapid scanning protocol for brain (18)F-FDG PET: a validation study
    Wei Ping Chen
    Ishikawa Sunrise Industries Creation Organization, Kanazawa, Japan
    J Nucl Med 46:1633-41. 2005
    ..The aim of this study was to validate a brain (18)F-FDG PET protocol more rapid than the conventional protocol...
  12. ncbi request reprint An application of a new planar positron imaging system (PPIS) in a small animal: MPTP-induced parkinsonism in mouse
    Hiroyuki Takamatsu
    The Medical and Pharmacological Research Center Foundation, Wo32, Inoyama, Hakui, Ishikawa 925 0613, Japan
    Ann Nucl Med 18:427-31. 2004
    ..To examine the usefulness of PPIS for functional study in small animals, we examined dopaminergic images of mouse striata in MPTP-induced parkinsonism...
  13. ncbi request reprint Synergistic effects of adenosine A2A antagonist and L-DOPA on rotational behaviors in 6-hydroxydopamine-induced hemi-Parkinsonian mouse model
    Takahiro Matsuya
    Laboratory of Neuropsychopharmacology, Division of Life Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa, Japan
    J Pharmacol Sci 103:329-32. 2007
    ..These findings suggest that adenosine A(2A) antagonists are extremely useful for pharmacotherapy of L-DOPA in Parkinson's disease patients...
  14. ncbi request reprint PET measurement of FK506 concentration in a monkey model of stroke
    Yoshihiro Murakami
    The Medical and Pharmacological Research Center Foundation, Hakui City, Ishikawa 925 0613, Japan
    Nucl Med Biol 34:703-7. 2007
    ....
  15. ncbi request reprint A PET study after treatment with an anxiety-provoking agent, m-chlorophenyl-piperazine, in conscious rhesus monkeys
    Hiroyuki Takamatsu
    Medical and Pharmacological Research Center Foundation, Inoyama Town, Hakui City, Ishikawa, Japan
    J Nucl Med 44:1516-21. 2003
    ....
  16. ncbi request reprint Pharmacokinetic animal PET study of FK506 as a potent neuroprotective agent
    Yoshihiro Murakami
    Medical and Pharmacological Research Center Foundation, Ishikawa 925 0613, Japan
    J Nucl Med 45:1946-9. 2004
    ..We have already established a rapid-synthesis method for (11)C-labeled FK506; therefore, in the present study, we aimed to establish a method to measure brain concentrations of FK506 using (11)C-FK506 PET in monkeys...
  17. doi request reprint Brain adenosine A2A receptor occupancy by a novel A1/A2A receptor antagonist, ASP5854, in rhesus monkeys: relationship to anticataleptic effect
    Takuma Mihara
    Pharmacology Research Laboratories, Astellas Pharma Inc, Tsukuba, Ibaraki, Japan
    J Nucl Med 49:1183-8. 2008
    ....
  18. ncbi request reprint Interleukin-8 production from human umbilical vein endothelial cells during brief hyperglycemia: the effect of tumor necrotic factor-alpha
    Kosaku Kinoshita
    Department of Emergency and Critical Care Medicine, Nihon University School of Medicine, Tokyo, Japan
    J Surg Res 144:127-31. 2008
    ....
  19. ncbi request reprint Involvement of a dysfunctional dopamine-D1/N-methyl-d-aspartate-NR1 and Ca2+/calmodulin-dependent protein kinase II pathway in the impairment of latent learning in a model of schizophrenia induced by phencyclidine
    Akihiro Mouri
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Mol Pharmacol 71:1598-609. 2007
    ..These findings indicate that repeated PCP treatment impairs latent learning through a prefrontal cortical dysfunction of NMDA-CaMKII signaling, which is associated with dopaminergic hypofunction...