Kyoji Morita

Summary

Affiliation: The University of Tokushima
Country: Japan

Publications

  1. ncbi Adrenergic activation of steroid 5alpha-reductase gene expression in rat C6 glioma cells: involvement of cyclic amp/protein kinase A-mediated signaling pathway
    Kyoji Morita
    Department of Pharmacology, Tokushima University Schoolof Medicine, Kuramoto, Tokushima 770 8503, Japan
    J Mol Neurosci 22:205-12. 2004
  2. ncbi Vinblastine enhancement of hyposmosis-induced catecholamine release in cultured adrenal chromaffin cells: lack of relation to cell swelling and microtubule disruption
    K Morita
    Department of Pharmacology, Tokushima University School of Medicine, Kuramoto, Japan
    Neurochem Int 32:309-16. 1998
  3. ncbi Serotonergic 5-HT2A receptor stimulation induces steroid 5alpha-reductase gene expression in rat C6 glioma cells via transcription factor Egr-1
    Kyoji Morita
    Department of Pharmacology, Tokushima University School of Medicine, 3 18 15 Kuramoto, Tokushima 770 8503, Japan
    Brain Res Mol Brain Res 139:193-200. 2005
  4. ncbi Down-regulation of immediate early gene egr-1 expression in rat C6 glioma cells by short-term exposure to high salt culture medium
    Kyoji Morita
    Department of Pharmacology, Tokushima University School of Medicine, 3 18 15 Kuramoto, Tokushima 770 8503, Japan
    Cell Biol Int 29:261-8. 2005
  5. ncbi Influence of serum-free culture conditions on steroid 5alpha-reductase mRNA expression in rat C6 glioma cells
    K Morita
    Department of Pharmacology, Tokushima University School of Medicine, 3 18 15 Kuramoto, Tokushima 770, Japan
    Brain Res 830:179-82. 1999
  6. ncbi In vitro cytotoxicity of 4-methylcatechol in murine tumor cells: induction of apoptotic cell death by extracellular pro-oxidant action
    Kyoji Morita
    Department of Pharmacology, Tokushima University School of Medicine, 3 18 15 Kuramoto, Tokushima 770 8503, Japan
    J Pharmacol Exp Ther 306:317-23. 2003
  7. ncbi Influence of sleep disturbance on steroid 5alpha-reductase mRNA levels in rat brain
    K Morita
    Neuroscience Group, Department of Pharmacology, Tokushima University School of Medicine, 3 18 15 Kuramoto, Japan
    Neuroscience 115:341-8. 2002
  8. ncbi Semi-quantitative RT-PCR analysis of environmental influence on P450scc and PNMT mRNA expression in rat adrenal glands
    K Morita
    Department of Pharmacology, Tokushima University School of Medicine, Kuramoto, Japan
    Life Sci 70:73-80. 2001
  9. ncbi Changes in the expression of steroid metabolism-related genes in rat adrenal glands during selective REM sleep deprivation
    Kyoji Morita
    Neuroscience Group in Department of Pharmacology, Tokushima University School of Medicine, 3 18 15 Kuramoto, Japan
    Life Sci 72:1973-82. 2003
  10. ncbi Dexamethasone enhances serum deprivation-induced necrotic death of rat C6 glioma cells through activation of glucocorticoid receptors
    K Morita
    Department of Pharmacology, Tokushima University School of Medicine, 3 18 15 Kuramoto, Tokushima 770 8503, Japan
    Brain Res 816:309-16. 1999

Collaborators

Detail Information

Publications64

  1. ncbi Adrenergic activation of steroid 5alpha-reductase gene expression in rat C6 glioma cells: involvement of cyclic amp/protein kinase A-mediated signaling pathway
    Kyoji Morita
    Department of Pharmacology, Tokushima University Schoolof Medicine, Kuramoto, Tokushima 770 8503, Japan
    J Mol Neurosci 22:205-12. 2004
    ....
  2. ncbi Vinblastine enhancement of hyposmosis-induced catecholamine release in cultured adrenal chromaffin cells: lack of relation to cell swelling and microtubule disruption
    K Morita
    Department of Pharmacology, Tokushima University School of Medicine, Kuramoto, Japan
    Neurochem Int 32:309-16. 1998
    ....
  3. ncbi Serotonergic 5-HT2A receptor stimulation induces steroid 5alpha-reductase gene expression in rat C6 glioma cells via transcription factor Egr-1
    Kyoji Morita
    Department of Pharmacology, Tokushima University School of Medicine, 3 18 15 Kuramoto, Tokushima 770 8503, Japan
    Brain Res Mol Brain Res 139:193-200. 2005
    ....
  4. ncbi Down-regulation of immediate early gene egr-1 expression in rat C6 glioma cells by short-term exposure to high salt culture medium
    Kyoji Morita
    Department of Pharmacology, Tokushima University School of Medicine, 3 18 15 Kuramoto, Tokushima 770 8503, Japan
    Cell Biol Int 29:261-8. 2005
    ....
  5. ncbi Influence of serum-free culture conditions on steroid 5alpha-reductase mRNA expression in rat C6 glioma cells
    K Morita
    Department of Pharmacology, Tokushima University School of Medicine, 3 18 15 Kuramoto, Tokushima 770, Japan
    Brain Res 830:179-82. 1999
    ..Therefore, the appearance of 5alpha-R immunoreactivity in the cell cytoplasm observed under serum-free conditions is probably not due to changes in 5alpha-R gene expression...
  6. ncbi In vitro cytotoxicity of 4-methylcatechol in murine tumor cells: induction of apoptotic cell death by extracellular pro-oxidant action
    Kyoji Morita
    Department of Pharmacology, Tokushima University School of Medicine, 3 18 15 Kuramoto, Tokushima 770 8503, Japan
    J Pharmacol Exp Ther 306:317-23. 2003
    ..These findings indicate that, similar to other catechol compounds, 4-methylcatechol may induce the apoptotic death of murine tumor cells through its extracellular pro-oxidant action on the cells...
  7. ncbi Influence of sleep disturbance on steroid 5alpha-reductase mRNA levels in rat brain
    K Morita
    Neuroscience Group, Department of Pharmacology, Tokushima University School of Medicine, 3 18 15 Kuramoto, Japan
    Neuroscience 115:341-8. 2002
    ....
  8. ncbi Semi-quantitative RT-PCR analysis of environmental influence on P450scc and PNMT mRNA expression in rat adrenal glands
    K Morita
    Department of Pharmacology, Tokushima University School of Medicine, Kuramoto, Japan
    Life Sci 70:73-80. 2001
    ....
  9. ncbi Changes in the expression of steroid metabolism-related genes in rat adrenal glands during selective REM sleep deprivation
    Kyoji Morita
    Neuroscience Group in Department of Pharmacology, Tokushima University School of Medicine, 3 18 15 Kuramoto, Japan
    Life Sci 72:1973-82. 2003
    ..These results indicate that REM sleep deprivation by itself may affect the expression of steroid metabolism-related genes in the adrenal gland, suggesting a possible relation between REM sleep and adrenocortical steroid metabolism...
  10. ncbi Dexamethasone enhances serum deprivation-induced necrotic death of rat C6 glioma cells through activation of glucocorticoid receptors
    K Morita
    Department of Pharmacology, Tokushima University School of Medicine, 3 18 15 Kuramoto, Tokushima 770 8503, Japan
    Brain Res 816:309-16. 1999
    ....
  11. ncbi Possible involvement of 5alpha-reduced neurosteroids in adrenergic and serotonergic stimulation of GFAP gene expression in rat C6 glioma cells
    Kyoji Morita
    Department of Pharmacology, Tokushima University School of Medicine, 3 18 15 Kuramoto, Tokushima 770 8503, Japan
    Brain Res 1085:49-56. 2006
    ....
  12. doi Progesterone pretreatment enhances serotonin-stimulated BDNF gene expression in rat c6 glioma cells through production of 5alpha-reduced neurosteroids
    Kyoji Morita
    Department of Pharmacology, Tokushima University School of Medicine, 3 18 15 Kuramoto, Tokushima, 770 8503, Japan
    J Mol Neurosci 34:193-200. 2008
    ....
  13. ncbi High salt culture conditions inhibit serum- and NGF- but not PMA-induced Egr-1 gene transcription in rat C6 glioma cells
    Kyoji Morita
    Department of Pharmacology, Tokushima University School of Medicine, 3 18 15 Kuramoto, Tokushima, Japan
    J Mol Neurosci 33:216-23. 2007
    ..These results suggest that the suppression of serum action on egr-1 gene transcription may be the primary and essential event leading to the down-regulation of egr-1 gene expression under the high salt culture conditions...
  14. doi Histone deacetylase inhibitors promote neurosteroid-mediated cell differentiation and enhance serotonin-stimulated brain-derived neurotrophic factor gene expression in rat C6 glioma cells
    Kyoji Morita
    Laboratory of Neuropharmacology, Department of Nursing, Shikoku University School of Health Sciences, Ohjin, Tokushima, Japan
    J Neurosci Res 87:2608-14. 2009
    ....
  15. ncbi Short-term sleep disturbance enhances brain-derived neurotrophic factor gene expression in rat hippocampus by acting as internal stressor
    Hiroaki Fujihara
    Department of Integrative Physiology, Tokushima University School of Medicine, Kuramoto, Tokushima 770 8503, Japan
    J Mol Neurosci 21:223-32. 2003
    ....
  16. ncbi High salt culture conditions suppress proliferation of rat C6 glioma cell by arresting cell-cycle progression at S-phase
    Hideki Arimochi
    Department of Molecular Bacteriology, Tokushima University School of Medicine, Kuramoto, Tokushima, Japan
    J Mol Neurosci 27:293-301. 2005
    ....
  17. doi Palytoxin causes nonoxidative necrotic damage to PC12 cells in culture
    Takefumi Sagara
    Laboratory of Cell Biology and Toxicology, Department of Food Science and Nutrition, Shikoku Junior College, Ohjin, Tokushima, 771 1192, Japan
    J Appl Toxicol 33:120-4. 2013
    ..Based on these observations, PTX is considered to cause cell death as a consequence of disrupting the plasma membranes, thus causing nonoxidative necrotic damage to PC12 cells...
  18. doi Possible relation of hemin-induced HO-1 expression to the upregulation of VEGF and BDNF mRNA levels in rat C6 glioma cells
    Kyoji Morita
    Laboratory of Neuropharmacology, Department of Nursing, Shikoku University School of Health Sciences, Ohjin, Tokushima, 771 1192, Japan
    J Mol Neurosci 38:31-40. 2009
    ....
  19. doi Production of apoptosis-inducing substances from soybean protein by Clostridium butyricum: characterization of their toxic effects on human colon carcinoma cells
    Hideki Arimochi
    Department of Molecular Bacteriology, Tokushima University School of Medicine, Kuramoto, Tokushima, Japan
    Cancer Lett 277:190-8. 2009
    ..Thus, enterobacteria are predicted to produce anti-tumor substances from food-derived proteins within the intestinal tract...
  20. ncbi Desipramine induces apoptotic cell death through nonmitochondrial and mitochondrial pathways in different types of human colon carcinoma cells
    Hideki Arimochi
    Department of Molecular Bacteriology, Tokushima University School of Medicine, Tokushima, Japan
    Pharmacology 81:164-72. 2008
    ....
  21. ncbi Single eight-hour shift of light-dark cycle increases brain-derived neurotrophic factor protein levels in the rat hippocampus
    Hiroyoshi Sei
    Department of Integrative Physiology, School of Medicine, The University of Tokushima, Tokushima 770 8503, Japan
    Life Sci 73:53-9. 2003
    ..Plasma corticosterone levels were not largely affected. Thus, a single LD shift acutely affects hippocampal BDNF metabolism with no large stress response...
  22. ncbi Glucocorticoids enhance serum deprivation- but not calcium-induced cytotoxicity in rat C6 glioma cells
    K Morita
    Department of Pharmacology, Tokushima University School of Medicine, Kuramoto, Tokushima, 770, Japan
    Cell Biol Int 24:223-8. 2000
    ....
  23. ncbi Characterization of cytotoxic actions of tricyclic antidepressants on human HT29 colon carcinoma cells
    Hideki Arimochi
    Department of Molecular Bacteriology, Tokushima University School of Medicine, 3 18 15 Kuramoto, Tokushima 770 8503, Japan
    Eur J Pharmacol 541:17-23. 2006
    ....
  24. ncbi Molecular cloning and characterization of rat trp homologues from brain
    N Mizuno
    Department of Pharmacology, Hiroshima University School of Dentistry, Kasumi 1 2 3, Minami Ku, Hiroshima, 734 8553, Japan
    Brain Res Mol Brain Res 64:41-51. 1999
    ..Isolation of cDNAs of rat trp gene family provides a useful model for studying mechanism of CCE...
  25. doi Trichostatin A enhances glutamate transporter GLT-1 mRNA levels in C6 glioma cells via neurosteroid-mediated cell differentiation
    Mari Itoh
    Laboratory of Neuropharmacology, Department of Nursing, Shikoku University School of Health Sciences, Ohjin, Tokushima 771 1192, Japan
    J Mol Neurosci 49:21-7. 2013
    ....
  26. ncbi Suppressive effect of Clostridium perfringens-produced heat-stable substance(s) on proliferation of human colon adenocarcinoma HT29 cells in culture
    Hideki Arimochi
    Department of Molecular Bacteriology, Graduate School of Medicine, The University of Tokushima, Kuramoto, Tokushima 770 8503, Japan
    Cancer Lett 241:228-34. 2006
    ..These observations suggest that C. perfringens culture medium has a cytostatic action on colon tumor cells, which may be responsible for the prevention of pre-neoplastic formation in rat colon...
  27. ncbi Influence of serum-free culture conditions on subcellular localization of steroid 5alpha-reductase in rat C6 glioma cells
    Y Tsuruo
    Department of Anatomy and Cell Biology, Tokushima University School of Medicine, Kuramoto, Tokushima, 770 8503, Japan
    Brain Res 801:130-6. 1998
    ....
  28. ncbi Differential effect of short-term REM sleep deprivation on NGF and BDNF protein levels in the rat brain
    H Sei
    Department of Physiology, School of Medicine, The University of Tokushima, Tokushima 770 8503, Japan
    Brain Res 877:387-90. 2000
    ..Conversely, in the hippocampus, NGF was significantly decreased while BDNF was not changed. This study indicates that REM sleep may be associated with the secretion of neurotrophic factors and thus contribute to the memory functions...
  29. ncbi Sodium-dependent phosphate co-transporters
    E Takeda
    Department of Clinical Nutrition, School of Medicine, University of Tokushima, Japan
    Int J Biochem Cell Biol 31:377-81. 1999
    ..The regulation of phosphatonin and Na+/Pi co-transporters may provide novel pharmacological approaches to the treatment of these diseases...
  30. doi Extract of fermented brown rice induces apoptosis of human colorectal tumor cells by activating mitochondrial pathway
    Mari Itoh
    Laboratory of Neuropharmacology, Department of Nursing, Shikoku University School of Health Sciences, Ohjin, Tokushima, 771 1192, Japan
    Phytother Res 26:1661-6. 2012
    ..Therefore, daily intake of FBRA can be expected to be beneficial for preventing carcinogenesis and/or suppressing tumor growth in the digestive tract...
  31. ncbi Influence of reduction of cytoplasmic ATP on catecholamine secretion from intact and digitonin-permeabilized adrenal chromaffin cells
    A Nakanishi
    Department of Pharmacology, Tokushima University School of Medicine, Japan
    Jpn J Pharmacol 46:109-15. 1988
    ..These results suggest that ATP in the cell cytoplasm may play an important role in the regulation of catecholamine secretion as a factor modulating the activity of the exocytotic process in the adrenal chromaffin cell...
  32. ncbi Mechanism of palytoxin-induced Na+ influx into cultured bovine adrenal chromaffin cells: possible involvement of Na+/H+ exchange system
    M Yoshizumi
    Department of Pharmacology, Tokushima University School of Medicine, Tokushima, Japan
    Neurosci Lett 130:103-6. 1991
    ..These results indicate that an amiloride-sensitive Na+/H+ exchange mechanism is probably involved in PTX-induced, TTX-insensitive Na+ influx that triggers Ca2+ influx and catecholamine secretion from the cells...
  33. ncbi Enhancement by GABA of the stimulation-evoked catecholamine release from cultured bovine adrenal chromaffin cells
    S Kitayama
    Department of Pharmacology, Hiroshima University School of Dentistry, Japan
    Naunyn Schmiedebergs Arch Pharmacol 341:414-8. 1990
    ..These results suggest a facilitatory modulation by GABA of basal and evoked release of CA from bovine adrenal medulla through GABAA receptor-mediated mechanisms...
  34. ncbi Nerve growth factor down-regulates the expression of norepinephrine transporter in rat pheochromocytoma (PC12) cells
    T Ikeda
    Department of Pharmacology, Hiroshima University Faculty of Dentistry, Kasumi 1-2-3, Minamiku, 734-8553, Hiroshima, Japan
    Brain Res Mol Brain Res 86:90-100. 2001
    ..The results indicate that the 2.1 kb NET flanking region displays promoter activity and is responsible for the NGF-induced down-regulation of NET expression...
  35. ncbi Inhibitory action of carvedilol, a novel alpha, beta-adrenoceptor antagonist, on catecholamine secretion and calcium influx in cultured bovine adrenal chromaffin cells
    K Morita
    Department of Pharmacology, Tokushima University School of Medicine, Japan
    Biochem Pharmacol 38:4461-5. 1989
    ....
  36. ncbi Requirement of ATP for exocytotic release of catecholamines from digitonin-permeabilized adrenal chromaffin cells
    K Morita
    Department of Pharmacology, Tokushima University School of Medicine, Japan
    J Neurochem 50:644-8. 1988
    ....
  37. ncbi GABAergic modulation of catecholamine release from cultured bovine adrenal chromaffin cells. Evidence for the involvement of Cl(-)-dependent Ca2+ entry
    S Kitayama
    Department of Pharmacology, Hiroshima University, School of Dentistry, Japan
    Naunyn Schmiedebergs Arch Pharmacol 341:419-24. 1990
    ..These results suggest that the Cl(-)-dependent process linked to GABAA receptor acts on voltage-sensitive Ca2+ channels in chromaffin cells to elicit and modulate CA release...
  38. doi Immunohistochemical studies on early stage of hepatic damage induced by subacute inhalation of toluene vapor in rats
    Takako Gotohda
    Department of Forensic Medicine, Tokushima University School of Medicine, Kuramoto, Tokushima 770 8503, Japan
    J Appl Toxicol 29:505-9. 2009
    ..These findings suggest that toluene inhalation may primarily induce hepatic damage, which may be secondarily exacerbated by the activation of systemic processes possibly connected with glucocorticoids and leptin...
  39. ncbi GABAA receptor-mediated increase of cytosolic Ca2+ in isolated bovine adrenal chromaffin cells
    S Kitayama
    Department of Pharmacology, Hiroshima University, School of Dentistry, Japan
    Biochim Biophys Acta 1053:189-94. 1990
    ..It is possible that GABA plays a modulatory role in the regulation of adrenal CA secretion as a facilitatory modulator...
  40. ncbi Benzodiazepines facilitate the stimulatory action of gamma-aminobutyric acid (GABA) on basal and veratridine-evoked catecholamine release from cultured bovine adrenal chromaffin cells
    S Kitayama
    Department of Pharmacology, Hiroshima University School of Dentistry, Japan
    Arch Int Pharmacodyn Ther 300:254-64. 1989
    ..These results suggest that the central-type benzodiazepine receptor participates in the GABAergic modulation of the catecholamine release from adrenal chromaffin cells...
  41. ncbi Tetrodotoxin-insensitive Na+ channel activator palytoxin inhibits tyrosine uptake into cultured bovine adrenal chromaffin cells
    K Morita
    Department of Pharmacology, Tokushima University School of Medicine, Japan
    Mol Pharmacol 40:112-7. 1991
    ....
  42. ncbi Enhancement by cytochalasin B of ouabain-stimulated catecholamine secretion from cultured bovine adrenal chromaffin cells: possible relation to alteration in Na+/K(+)-pump activity
    K Morita
    Department of Pharmacology, Tokushima University School of Medicine, Japan
    Cell Mol Neurobiol 10:525-37. 1990
    ..Thus, the present study provides an evidence for a possible role of microfilaments as one of the intrinsic factors modulating the plasma membrane functions...
  43. ncbi Characterization of palytoxin-induced catecholamine secretion from cultured bovine adrenal chromaffin cells. Effects of Na(+)- and Ca(2+)-channel blockers
    M Yoshizumi
    Department of Cardiovascular Surgery, Tokushima University School of Medicine, Japan
    Biochem Pharmacol 42:17-23. 1991
    ....
  44. ncbi Palytoxin: a potent stimulator of catecholamine release from cultured bovine adrenal chromaffin cells
    A Nakanishi
    Department of Pharmacology, Tokushima University School of Medicine, Japan
    Neurosci Lett 121:163-5. 1991
    ..These results indicated that PTX-induced catecholamine release was mediated by activation of Na(+)-dependent, tetrodotoxin (TTX) insensitive voltage-dependent Ca2+ channels...
  45. ncbi Idebenone inhibits catecholamine secretion through its blocking action on Ca2+ channels in cultured adrenal chromaffin cells
    H Houchi
    Department of Pharmacology, Tokushima University School of Medicine, Japan
    Jpn J Pharmacol 57:553-8. 1991
    ....
  46. ncbi Dominant negative isoform of rat norepinephrine transporter produced by alternative RNA splicing
    S Kitayama
    Department of Pharmacology, Hiroshima University School of Dentistry, Kasumi 1 2 3, Minami Ku, Hiroshima 734, Japan
    J Biol Chem 274:10731-6. 1999
    ..No reduction was found with the glutamate/aspartate transporter (rGLAST). Alternative RNA splicing of NET suggests a novel mechanism for the regulation of synaptic transmission...
  47. ncbi Enhancement of glial cell line-derived neurotrophic factor expression in rat adrenal glands by toluene exposure
    T Gotohda
    Department of Legal Medicine, Tokushima University School of Medicine, Kuramoto, Japan
    Horm Metab Res 32:301-5. 2000
    ....
  48. ncbi Possible involvement of nitric oxide in acetylcholine-induced increase of intracellular Ca2+ concentration and catecholamine release in bovine adrenal chromaffin cells
    Y Uchiyama
    Department of Pharmacology, Hiroshima University School of Dentistry, Japan
    Jpn J Pharmacol 65:73-7. 1994
    ..These results suggest a possible involvement of NO in ACh-induced [Ca2+]i rise and CA release in bovine adrenal chromaffin cells...
  49. pmc Regulation of intestinal Na+-dependent phosphate co-transporters by a low-phosphate diet and 1,25-dihydroxyvitamin D3
    K Katai
    Department of Clinical Nutrition, School of Medicine, Tokushima University, Kuramoto Cho 3, Tokushima City, Tokushima 770, Japan
    Biochem J 343:705-12. 1999
    ..PiUS and PiT-2 might be important components in the regulation of the intestinal P(i) transport system by P(i) restriction and 1,25-(OH)(2)D(3)...
  50. ncbi Identification of three isoforms for the Na+-dependent phosphate cotransporter (NaPi-2) in rat kidney
    S Tatsumi
    Department of Clinical Nutrition, School of Medicine, Tokushima University, Tokushima 770, Japan
    J Biol Chem 273:28568-75. 1998
    ..The results suggest that these short isoforms may function as a dominant negative inhibitor of the full-length transporter...
  51. doi In vitro cytotoxic effect of ethanol extract prepared from sporophyll of Undaria pinnatifida on human colorectal cancer cells
    Naoyoshi Nishibori
    Laboratory of Cell Biology, Department of Food Science and Nutrition, Shikoku Junior College, Ohjin, Tokushima 771 1192, Japan
    Phytother Res 26:191-6. 2012
    ....
  52. ncbi Evaluation of systemic blood NO dynamics by EPR spectroscopy: HbNO as an endogenous index of NO
    Kazuyoshi Kirima
    Department of Pharmacology, The University of Tokushima School of Medicine, 3 18 15 Kuramoto, Tokushima 770 8503, Japan
    Am J Physiol Heart Circ Physiol 285:H589-96. 2003
    ..We also demonstrated that temocapril improves abnormalities of NO dynamics in L-NAME-induced endothelial dysfunction rats using the EPR HbNO signal subtraction method...
  53. ncbi Involvement of Ca2+ entry and inositol trisphosphate-induced internal Ca2+ mobilization in muscarinic receptor-mediated catecholamine release in dog adrenal chromaffin cells
    H Ohtsuki
    Department of Pharmacology, Hiroshima University, School of Dentistry, Japan
    Neurochem Int 21:259-67. 1992
    ..Muscarine increased cellular Ins(1,4,5)P3 production, and atropine inhibited this increase.(ABSTRACT TRUNCATED AT 250 WORDS)..
  54. ncbi MPP+ toxicity and plasma membrane dopamine transporter: study using cell lines expressing the wild-type and mutant rat dopamine transporters
    S Kitayama
    Department of Pharmacology, Hiroshima University School of Dentistry, Kasumi 1 2 3, Minami Ku, Hiroshima 734, Japan
    Biochim Biophys Acta 1404:305-13. 1998
    ..These results suggest that re-distribution of MPP+ due to influx/efflux turnover through the transporter is a key factor in MPP+ toxicity...
  55. pmc Gene structure and functional analysis of the human Na+/phosphate co-transporter
    Y Taketani
    Department of Clinical Nutrition, School of Medicine, University of Tokushima, Kuramoto Cho 3, Tokushima 770, Japan
    Biochem J 324:927-34. 1997
    ..The presence of the three vitamin D receptor- responsive elements in the NaPi-3 promoter may be important in mediating the enhanced expression of the gene by 1,25-dihydroxyvitamin D3...
  56. ncbi Effects of cytoskeleton-disrupting agents on tyrosine transport into cultured bovine adrenal chromaffin cells
    K Morita
    Department of Pharmacology, Tokushima University School of Medicine, Japan
    Biochem Int 18:991-8. 1989
    ..While colchicine failed to cause any significant increase in the transport under the same conditions. These results therefore suggest a possible role of microfilaments as a factor regulating tyrosine transport into chromaffin cells...
  57. ncbi Inhibitory action of palytoxin on ascorbic acid transport into cultured bovine adrenal chromaffin cells
    K Morita
    Department of Pharmacology, Tokushima University School of Medicine, Japan
    J Pharmacol Exp Ther 276:996-1001. 1996
    ....
  58. ncbi Functional characterization of the splicing variants of human norepinephrine transporter
    S Kitayama
    Department of Pharmacology, Faculty of Dentistry, Hiroshima University, Hiroshima 734 8553, Japan
    Neurosci Lett 312:108-12. 2001
    ..These results suggest that hNET C-t var2 may participate in NE transport in a manner different from hNET at noradrenergic synapses or in other tissues including placenta where NET variants were found to exist...
  59. ncbi Bis-oxonol experiment on plasma membrane potentials of bovine adrenal chromaffin cells: depolarizing stimuli and their possible interaction
    S Kitayama
    Department of Pharmacology, Hiroshima University School of Dentistry, Japan
    Neurosci Lett 116:275-9. 1990
    ..These results suggest that chromaffin cells in vitro reveal an additively enhanced change of plasma membrane potential in response to the combination of depolarizing stimuli...
  60. ncbi Inhibition by amiloride of ouabain-evoked catecholamine secretion from cultured adrenal chromaffin cells: evidence for its blocking action on interaction between ouabain and Na+/K(+)-pump
    K Morita
    Department of Pharmacology, Tokushima University School of Medicine, Japan
    J Pharmacol Exp Ther 262:1209-13. 1992
    ..These results suggest that amiloride may inhibit ouabain-evoked catecholamine secretion as a consequence of blocking the inhibitory action of ouabain on the plasma membrane Na+/K(+)-pump in adrenal chromaffin cells...
  61. pmc Cloning, functional expression and dietary regulation of the mouse neutral and basic amino acid transporter (NBAT)
    H Segawa
    Department of Clinical Nutrition, School of Medicine, Tokushima University, Kuramoto Cho 3, Tokushima 770, Japan
    Biochem J 328:657-64. 1997
    ..These results demonstrate that mouse NBAT has an important role in cystine transport...
  62. ncbi Effects of truncation of the COOH-terminal region of a Na+-independent neutral and basic amino acid transporter on amino acid transport in Xenopus oocytes
    K Miyamoto
    Department of Clinical Nutrition, School of Medicine, Tokushima University, Kuramoto Cho 3, Tokushima 770, Japan
    J Biol Chem 271:16758-63. 1996
    ..These results suggest that NBAT functions as a activator of the amino acid transport system in Xenopus oocytes...
  63. ncbi Cyclic AMP-induced depolarization measured by bis-oxonol fluorescence in bovine adrenal medullary chromaffin cells
    N Minami
    Department of Pharmacology, Hiroshima University School of Dentistry, Japan
    J Neural Transm Gen Sect 97:65-72. 1994
    ..These results may suggest that cyclic AMP causes the membrane depolarization by accumulating Na+ through the inhibition of Na+, K+-ATPase in adrenal chromaffin cells...
  64. ncbi Nerve growth factor induces elevation of steroid 5alpha-reductase mRNA levels in rat C6 glioma cells through expression of transcription factor Egr-1
    Song Her
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5485, USA
    Brain Res Mol Brain Res 126:157-64. 2004
    ....