T Matsumoto

Summary

Affiliation: The University of Tokushima
Country: Japan

Publications

  1. ncbi request reprint Regulation of osteoblast differentiation by interleukin-11 via AP-1 and Smad signaling
    Toshio Matsumoto
    Department of Medicine and Bioregulatory Sciences, The University of Tokushima Graduate School of Medical Sciences, Tokushima, Japan
    Endocr J 59:91-101. 2012
  2. doi request reprint Osteoporosis treatment by a new active vitamin D3 compound, eldecalcitol, in Japan
    Toshio Matsumoto
    University of Tokushima Graduate School of Medical Sciences, Japan
    Curr Osteoporos Rep 10:248-50. 2012
  3. doi request reprint Eldecalcitol for the treatment of osteoporosis
    T Matsumoto
    University of Tokushima Graduate School of Medical Sciences, Kuramoto Cho, Tokushima, Japan
    Drugs Today (Barc) 48:189-96. 2012
  4. ncbi request reprint ED-71, a new active vitamin D3, increases bone mineral density regardless of serum 25(OH)D levels in osteoporotic subjects
    Toshio Matsumoto
    Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Health Biosciences, 3 18 15 Kuramoto cho, Tokushima 770 8503, Japan
    J Steroid Biochem Mol Biol 103:584-6. 2007
  5. doi request reprint A new active vitamin D3 analog, eldecalcitol, prevents the risk of osteoporotic fractures--a randomized, active comparator, double-blind study
    Toshio Matsumoto
    Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Medical Sciences, Tokushima 770 8503, Japan
    Bone 49:605-12. 2011
  6. ncbi request reprint A new active vitamin D, ED-71, increases bone mass in osteoporotic patients under vitamin D supplementation: a randomized, double-blind, placebo-controlled clinical trial
    Toshio Matsumoto
    Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Health Biosciences, 3 18 15 Kuramoto cho, Tokushima 770 8503, Japan
    J Clin Endocrinol Metab 90:5031-6. 2005
  7. pmc Effect of daily oral minodronate on vertebral fractures in Japanese postmenopausal women with established osteoporosis: a randomized placebo-controlled double-blind study
    T Matsumoto
    Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Medical Science, Tokushima 770 8503, Japan
    Osteoporos Int 20:1429-37. 2009
  8. ncbi request reprint Comparative study of incadronate and elcatonin in patients with malignancy-associated hypercalcaemia
    T Matsumoto
    First Department of Internal Medicine, School of Medicine, University of Tokushima, Tokushima, Japan
    J Int Med Res 30:230-43. 2002
  9. doi request reprint TGF-β-related mechanisms of bone destruction in multiple myeloma
    Toshio Matsumoto
    Department of Medicine and Bioregulatory Sciences, The University of Tokushima Graduate School of Medical Sciences, Tokushima, Japan
    Bone 48:129-34. 2011
  10. ncbi request reprint Bone destruction in multiple myeloma
    Toshio Matsumoto
    Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Health Biosciences, 3 18 15 Kuramoto cho, Tokushima 770 8503, Japan
    Ann N Y Acad Sci 1068:319-26. 2006

Collaborators

  • Masahiro Abe
  • M Hayashi
  • M Fujii
  • M Ohnishi
  • A Wada
  • I Endo
  • T Tsutsui
  • K Maeda
  • Daisuke Inoue
  • T Yamamoto
  • K Takahashi
  • H Inatomi
  • Y Saito
  • M Kawajiri
  • M Takahashi
  • Y Sugimoto
  • T Nakamura
  • S Mori
  • K Yokote
  • Kenichiro Yata
  • Shuji Ozaki
  • Kyoko Takeuchi
  • Toshihiro Hashimoto
  • Ayako Nakano
  • Hirokazu Miki
  • Kumiko Kagawa
  • T Tsutamoto
  • Asuka Oda
  • Hiroe Amou
  • Masahiro Hiasa
  • T Mitsui
  • M Kinoshita
  • Hironobu Shibata
  • Takeshi Harada
  • Shingen Nakamura
  • M Kunishige
  • Shinsuke Kido
  • Shiro Fujii
  • Qu Cui
  • Tomoko Hara
  • H Horie
  • N Mabuchi
  • Ken ichi Kitazoe
  • Etsuko Sekimoto
  • M Sawaki
  • Yoichi Tanaka
  • Shingo Wakatsuki
  • M Takemoto
  • Osamu Tanaka
  • Shusuke Yagi
  • Masashi Akaike
  • T Shigekiyo
  • Keiji Moriyama
  • Y Oshima
  • Takashi Oshima
  • A Ikegame
  • S Akasaka
  • S Nakamura
  • K Aihara
  • K Kagawa
  • S Fujii
  • Mitsunori Fujimura
  • A Nakano
  • T Harada
  • M Hiasa
  • H Miki
  • S Ozaki
  • K Takeuchi
  • Keiichiro Watanabe
  • Shunji Hashizume
  • J Asano
  • Akira Sakai
  • Akishige Ikegame
  • Takako Taniguchi
  • Michihiro Nakamura
  • Yasumasa Ikeda
  • Ken ichi Aihara
  • N Matsui
  • K Imai
  • Takashi Iwase
  • Hiroyuki Azuma
  • K Minai
  • T Muratani
  • X Wang
  • T Omura
  • Jin Asano
  • H Azuma
  • M Akaike
  • Kenichi Kitazoe
  • Y Kanagawa

Detail Information

Publications96

  1. ncbi request reprint Regulation of osteoblast differentiation by interleukin-11 via AP-1 and Smad signaling
    Toshio Matsumoto
    Department of Medicine and Bioregulatory Sciences, The University of Tokushima Graduate School of Medical Sciences, Tokushima, Japan
    Endocr J 59:91-101. 2012
    ..These observations are consistent with the notion that IL-11 mediates stimulatory and inhibitory signals of osteoblast differentiation by affecting Wnt signaling...
  2. doi request reprint Osteoporosis treatment by a new active vitamin D3 compound, eldecalcitol, in Japan
    Toshio Matsumoto
    University of Tokushima Graduate School of Medical Sciences, Japan
    Curr Osteoporos Rep 10:248-50. 2012
    ....
  3. doi request reprint Eldecalcitol for the treatment of osteoporosis
    T Matsumoto
    University of Tokushima Graduate School of Medical Sciences, Kuramoto Cho, Tokushima, Japan
    Drugs Today (Barc) 48:189-96. 2012
    ..Eldecalcitol is well tolerated and is not associated with serious side effects including sustained hypercalcemia. Eldecalcitol was approved for the treatment of osteoporosis in Japan in 2011...
  4. ncbi request reprint ED-71, a new active vitamin D3, increases bone mineral density regardless of serum 25(OH)D levels in osteoporotic subjects
    Toshio Matsumoto
    Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Health Biosciences, 3 18 15 Kuramoto cho, Tokushima 770 8503, Japan
    J Steroid Biochem Mol Biol 103:584-6. 2007
    ....
  5. doi request reprint A new active vitamin D3 analog, eldecalcitol, prevents the risk of osteoporotic fractures--a randomized, active comparator, double-blind study
    Toshio Matsumoto
    Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Medical Sciences, Tokushima 770 8503, Japan
    Bone 49:605-12. 2011
    ..The objective of this study is to examine whether eldecalcitol is superior to alfacalcidol in preventing osteoporotic fractures. This trial is registered with ClinicalTrials.gov, number NCT00144456...
  6. ncbi request reprint A new active vitamin D, ED-71, increases bone mass in osteoporotic patients under vitamin D supplementation: a randomized, double-blind, placebo-controlled clinical trial
    Toshio Matsumoto
    Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Health Biosciences, 3 18 15 Kuramoto cho, Tokushima 770 8503, Japan
    J Clin Endocrinol Metab 90:5031-6. 2005
    ..ED-71 has been shown to increase lumbar bone mineral density (BMD) in osteoporotic subjects. However, vitamin D insufficiency might have influenced the effect of ED-71 on BMD...
  7. pmc Effect of daily oral minodronate on vertebral fractures in Japanese postmenopausal women with established osteoporosis: a randomized placebo-controlled double-blind study
    T Matsumoto
    Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Medical Science, Tokushima 770 8503, Japan
    Osteoporos Int 20:1429-37. 2009
    ..Minodronate treatment reduced vertebral fractures by 59% without serious adverse events. Minodronate is a safe and effective bisphosphonate for osteoporosis treatment...
  8. ncbi request reprint Comparative study of incadronate and elcatonin in patients with malignancy-associated hypercalcaemia
    T Matsumoto
    First Department of Internal Medicine, School of Medicine, University of Tokushima, Tokushima, Japan
    J Int Med Res 30:230-43. 2002
    ....
  9. doi request reprint TGF-β-related mechanisms of bone destruction in multiple myeloma
    Toshio Matsumoto
    Department of Medicine and Bioregulatory Sciences, The University of Tokushima Graduate School of Medical Sciences, Tokushima, Japan
    Bone 48:129-34. 2011
    ..Inhibition of TGF-β signaling can become a new therapeutic approach against MM...
  10. ncbi request reprint Bone destruction in multiple myeloma
    Toshio Matsumoto
    Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Health Biosciences, 3 18 15 Kuramoto cho, Tokushima 770 8503, Japan
    Ann N Y Acad Sci 1068:319-26. 2006
    ..Further elucidation of the mechanism of bone destruction by MM may lead to a novel therapeutic approach to prevent bone destruction and tumor growth...
  11. doi request reprint Comparison of the effects of eldecalcitol and alfacalcidol on bone and calcium metabolism
    Toshio Matsumoto
    Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Medical Sciences, 3 18 15 Kuramoto cho, Tokushima 770 8503, Japan
    J Steroid Biochem Mol Biol 121:261-4. 2010
    ....
  12. ncbi request reprint Daily nasal spray of hPTH(1-34) for 3 months increases bone mass in osteoporotic subjects: a pilot study
    T Matsumoto
    Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Health Biosciences, Tokushima, 770 8503, Japan
    Osteoporos Int 17:1532-8. 2006
    ..We have developed a nasal spray formula of parathyroid peptide [hPTH(1-34)] with peak serum hPTH(1-34) concentrations by nasal spray of 1,000 microg similar to those by subcutaneous injections of 20 microg hPTH(1-34)...
  13. ncbi request reprint Effect of mechanical unloading and reloading on periosteal bone formation and gene expression in tail-suspended rapidly growing rats
    T Matsumoto
    First Department of Internal Medicine, University of Tokushima School of Medicine, Japan
    Bone 22:89S-93S. 1998
    ..The intercellular signaling cascade that mediates the enhancement of c-fos expression in periosteal cells in response to mechanical stimulation remains to be elucidated...
  14. ncbi request reprint Transcardiac extraction of circulating endothelin-1 across the failing heart
    T Tsutamoto
    First Department of Internal Medicine, Shiga University of Medical Science, Seta, Otsu, Japan
    Am J Cardiol 86:524-8. 2000
    ....
  15. ncbi request reprint Spironolactone inhibits the transcardiac extraction of aldosterone in patients with congestive heart failure
    T Tsutamoto
    First Department of Internal Medicine, Shiga University of Medical Science, Seta, Otsu, Japan
    J Am Coll Cardiol 36:838-44. 2000
    ..The study evaluated the transcardiac extraction or spillover of aldosterone (ALDO) in normal subjects and in patients with congestive heart failure (CHF)...
  16. ncbi request reprint Enhanced expression of osteopontin by high glucose in cultured rat aortic smooth muscle cells
    M Takemoto
    School of Medicine, Chiba University, 1 8 1 Inohana, Chiba, Chuou ku, 260 0856, Japan
    Biochem Biophys Res Commun 258:722-6. 1999
    ..Our results suggest that osteopontin could play a role in the development of diabetic vascular complications...
  17. pmc Tgf-Beta inhibition restores terminal osteoblast differentiation to suppress myeloma growth
    Kyoko Takeuchi
    Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Medicine, Tokushima, Japan
    PLoS ONE 5:e9870. 2010
    ..The present study was therefore undertaken to clarify the role of TGF-beta and its inhibition in bone formation and tumor growth in MM...
  18. ncbi request reprint Relationship between plasma level of cardiotrophin-1 and left ventricular mass index in patients with dilated cardiomyopathy
    T Tsutamoto
    First Department of Internal Medicine, Shiga University of Medical Science, Otsu, Japan
    J Am Coll Cardiol 38:1485-90. 2001
    ..The study evaluated the relationship between plasma cardiotrophin-1 (CT-1) concentration and left ventricular (LV) mass in dilated cardiomyopathy (DCM) patients with congestive heart failure (CHF)...
  19. ncbi request reprint Angiotensin II type 1 receptor antagonist decreases plasma levels of tumor necrosis factor alpha, interleukin-6 and soluble adhesion molecules in patients with chronic heart failure
    T Tsutamoto
    First Department of Internal Medicine, Shiga University of Medical Science, Tsukinowa, Seta, Otsu, Japan
    J Am Coll Cardiol 35:714-21. 2000
    ..To evaluate the effects of an angiotensin (Ang II) type 1 receptor antagonist on immune markers in patients with congestive heart failure (CHF)...
  20. ncbi request reprint Osteoclasts enhance myeloma cell growth and survival via cell-cell contact: a vicious cycle between bone destruction and myeloma expansion
    Masahiro Abe
    Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Medicine, 3 18 15 Kuramoto cho, Tokushima, 770 8503, Japan
    Blood 104:2484-91. 2004
    ..It is suggested that interactions of MM cells with OCs augment MM growth and survival and, thereby, form a vicious cycle, leading to extensive bone destruction and MM cell expansion...
  21. pmc Outbreak of cefozopran (penicillin, oral cephems, and aztreonam)-resistant Neisseria gonorrhoeae in Japan
    T Muratani
    Department of Urology, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu, Japan
    Antimicrob Agents Chemother 45:3603-6. 2001
    ..Restriction fragment length polymorphism DNA typing revealed that the outbreak of cefozopran-resistant isolates in Kitakyushu, Japan, occurred as a result of clonal spread...
  22. ncbi request reprint Effect of spironolactone on plasma brain natriuretic peptide and left ventricular remodeling in patients with congestive heart failure
    T Tsutamoto
    First Department of Internal Medicine, Shiga University of Medical Science, Seta, Otsu, Japan
    J Am Coll Cardiol 37:1228-33. 2001
    ..We sought to evaluate the effects of spironolactone on neurohumoral factors and left ventricular remodeling in patients with congestive heart failure (CHF)...
  23. doi request reprint Valproic acid exerts anti-tumor as well as anti-angiogenic effects on myeloma
    Ken ichi Kitazoe
    Department of Medicine and Bioregulatory Sciences, Graduate School of Medical Sciences, University of Tokushima, 3 18 15 Kuramoto cho, Tokushima, 770 8503, Japan
    Int J Hematol 89:45-57. 2009
    ..Collectively, VPA is suggested to exert multi-factorial anti-myeloma actions, and may serve as a safe adjuvant to be included in conventional chemotherapies against myeloma...
  24. ncbi request reprint Relationship between transcardiac extraction of aldosterone and left ventricular remodeling in patients with first acute myocardial infarction: extracting aldosterone through the heart promotes ventricular remodeling after acute myocardial infarction
    M Hayashi
    First Department of Internal Medicine, Shiga University of Medical Science, Seta-Tsukinowa, Otsu, Japan
    J Am Coll Cardiol 38:1375-82. 2001
    ..CONCLUSIONS: These results indicate that plasma ALD is extracted through the heart in patients with AMI at the acute phase and that the extracted ALD plays an important role in modulating post-infarct LV remodeling...
  25. ncbi request reprint Malignant B-lymphoid cells with bone lesions express receptor activator of nuclear factor-kappaB ligand and vascular endothelial growth factor to enhance osteoclastogenesis
    Hironobu Shibata
    Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Health Biosciences, Tokushima, Japan
    Clin Cancer Res 11:6109-15. 2005
    ....
  26. ncbi request reprint Myeloma cell-osteoclast interaction enhances angiogenesis together with bone resorption: a role for vascular endothelial cell growth factor and osteopontin
    Yoichi Tanaka
    Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Medical Sciences, and Division of Transfusion Medicine, Tokushima University Hospital, Japan
    Clin Cancer Res 13:816-23. 2007
    ..The present study was undertaken to clarify whether myeloma cell-osteoclast interaction enhances angiogenesis and whether there is any mutual stimulation between osteoclastogenesis and angiogenesis...
  27. doi request reprint Delayed treatment with vitamin C and N-acetyl-L-cysteine protects Schwann cells without compromising the anti-myeloma activity of bortezomib
    Ayako Nakano
    Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Medicine, 3 18 15 Kuramoto cho, Tokushima 770 8503, Japan
    Int J Hematol 93:727-35. 2011
    ..These results suggest that delayed treatment with these agents may be instrumental in prophylaxis of BIPN...
  28. ncbi request reprint Myeloma cells suppress bone formation by secreting a soluble Wnt inhibitor, sFRP-2
    Takashi Oshima
    Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Medicine, 3 18 15 Kuramoto cho, Tokushima, 770 8503, Japan
    Blood 106:3160-5. 2005
    ..Thus, in addition to enhanced osteolysis, MM cells also suppress bone formation at least in part through an inhibition of the canonical Wnt pathway by secreting sFRP-2...
  29. doi request reprint GM-CSF and IL-4 induce dendritic cell differentiation and disrupt osteoclastogenesis through M-CSF receptor shedding by up-regulation of TNF-alpha converting enzyme (TACE)
    Masahiro Hiasa
    Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Medical Sciences, Tokushima, Japan
    Blood 114:4517-26. 2009
    ..These results reveal a novel proteolytic regulation of M-CSF receptor expression in monocytes to control M-CSF signaling and monocytic differentiation into macrophage/OC-lineage cells or DCs...
  30. doi request reprint Vicious cycle between myeloma cell binding to bone marrow stromal cells via VLA-4-VCAM-1 adhesion and macrophage inflammatory protein-1alpha and MIP-1beta production
    Masahiro Abe
    Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Medical Sciences, 3 18 15 Kuramoto cho, Tokushima 770 8503, Japan
    J Bone Miner Metab 27:16-23. 2009
    ....
  31. ncbi request reprint Enhanced expression of osteopontin in human diabetic artery and analysis of its functional role in accelerated atherogenesis
    M Takemoto
    Second Department of Internal Medicine, School of Medicine, Chiba University, Chiba, Japan
    Arterioscler Thromb Vasc Biol 20:624-8. 2000
    ..Taken together, our present results raise a possibility that OPN plays a role in the development of diabetic vascular complications...
  32. ncbi request reprint Relationship between tumor necrosis factor-alpha production and oxidative stress in the failing hearts of patients with dilated cardiomyopathy
    T Tsutamoto
    First Department of Internal Medicine, Shiga University of Medical Science, Otsu, Japan
    J Am Coll Cardiol 37:2086-92. 2001
    ..This study evaluated oxidative stress in the failing ventricle in patients with dilated cardiomyopathy (DCM)...
  33. doi request reprint Marked improvement of platelet transfusion refractoriness after bortezomib therapy in multiple myeloma
    Hirokazu Miki
    Department of Medicine and Bioregulatory Sciences, The University of Tokushima Graduate School of Health Biosciences, 3 18 15 Kuramoto, Tokushima 770 8503, Japan
    Int J Hematol 89:223-6. 2009
    ..9%. In addition, platelet transfusion from random donors showed clinical effects after BD therapy. This case suggests that bortezomib might be effective in different types of immune disease by inhibiting allo-reactive antibody...
  34. ncbi request reprint Induction of HM1.24 peptide-specific cytotoxic T lymphocytes by using peripheral-blood stem-cell harvests in patients with multiple myeloma
    Ali Jalili
    Department of Medicine and Bioregulatory Sciences, Institute of Health Biosciences, University of Tokushima Graduate School, Japan
    Blood 106:3538-45. 2005
    ..These results indicate the existence of functional DCs and HM1.24-specific CTL precursors within PBSC harvests and provide the basis for cellular immunotherapy in combination with autologous PBSC transplantation in MM...
  35. ncbi request reprint Ability of myeloma cells to secrete macrophage inflammatory protein (MIP)-1alpha and MIP-1beta correlates with lytic bone lesions in patients with multiple myeloma
    Toshihiro Hashimoto
    Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Medicine Division of Transfusion Medicine, Tokushima University Hospital, Tokushima, Japan
    Br J Haematol 125:38-41. 2004
    ....
  36. doi request reprint Small molecule antibody targeting HLA class I inhibits myeloma cancer stem cells by repressing pluripotency-associated transcription factors
    A Ikegame
    Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Medical Sciences, Tokushima, Japan
    Leukemia 26:2124-34. 2012
    ..Thus, our findings reveal that immunotherapeutic approach by engineered antibodies can overcome drug resistance, and provide a new basis for development of cancer stem cell-targeted therapy...
  37. ncbi request reprint Functional association between nicotinic acetylcholine receptor and sarcomeric proteins via actin and desmin filaments
    T Mitsui
    First Department of Internal Medicine, School of Medicine, University of Tokushima, Tokushima 770 8503, Japan
    J Cell Biochem 77:584-95. 2000
    ..From these findings, it is suggested that desmin and actin form a submembranous organization in the postsynaptic region, and function as mediators of excitation of AChR to the sarcomeric contraction system...
  38. ncbi request reprint Cardioprotective effects of nicorandil in rabbits anaesthetized with halothane: potentiation of ischaemic preconditioning via KATP channels
    I Nakae
    First Department of Internal Medicine, Medical Coordination Center, Shiga University of Medical Science, Seta, Otsu, Japan
    Clin Exp Pharmacol Physiol 27:810-7. 2000
    ..Key words: ATP-sensitive K+ (KATP) channel, ischaemic preconditioning, myocardial infarction, nicorandil, rabbit...
  39. ncbi request reprint Coronary vasomotor responses to bradykinin and acetylcholine in patients with coronary spastic angina
    T Matsumoto
    First Department of Internal Medicine, Shiga University of Medical Science, Otsu, Japan
    Jpn Circ J 65:1052-6. 2001
    ..The coronary vasodilation response induced by BK may not deteriorate until coronary atherosclerosis advances in patients with CSA...
  40. ncbi request reprint A single-chain Fv diabody against human leukocyte antigen-A molecules specifically induces myeloma cell death in the bone marrow environment
    Etsuko Sekimoto
    Department of Medicine and Bioregulatory Sciences, The University of Tokushima Graduate School of Health Biosciences, 3 18 15 Kuramoto, Tokushima 770 8503, Japan
    Cancer Res 67:1184-92. 2007
    ..These results indicate that 2D7-DB acts on multiple myeloma cells differently from other bone marrow cells and thus provide the basis for a novel HLA class I-targeting therapy against multiple myeloma...
  41. ncbi request reprint [Biochemical markers in bone metastasis]
    Toshihiro Hashimoto
    Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Medicine, 3 18 15 Kuramoto cho, Tokushima 770 8503, Japan
    Gan To Kagaku Ryoho 31:1027-33. 2004
    ..Serum levels of these factors and/or their ratios may provide additional information on the severity of bone disease and the prognosis...
  42. ncbi request reprint Angiographically documented coronary steal phenomenon evoked by the intracoronary infusion of bradykinin
    H Horie
    First Department of Internal Medicine, Shiga University of Medical Science, Otsu, Japan
    Jpn Circ J 65:123-5. 2001
    ..This is angiographic confirmation of the coronary steal phenomenon that has been previously described in the field of stress scintigraphy...
  43. doi request reprint KRN5500, a spicamycin derivative, exerts anti-myeloma effects through impairing both myeloma cells and osteoclasts
    Hirokazu Miki
    Department of Medicine and Bioregulatory Sciences, The University of Tokushima Graduate School of Health Biosciences, Japan
    Br J Haematol 155:328-39. 2011
    ..These results suggest that KRN5500 exerts anti-MM effects through impairing both MM cells and osteoclasts. Therefore, this unique mechanism of KRN5500 might be a useful therapeutic option in patients with MM...
  44. ncbi request reprint Therapy with bortezomib plus dexamethasone induces osteoblast activation in responsive patients with multiple myeloma
    Shuji Ozaki
    Department of Medicine and Bioregulatory Sciences, The University of Tokushima Graduate School of Health Biosciences, Kuramoto, Tokushima, Japan
    Int J Hematol 86:180-5. 2007
    ..Our results suggest that BD therapy is a safe and promising therapeutic approach for Japanese patients with MM...
  45. ncbi request reprint Primary adult T-cell leukemia/lymphoma of bone
    Tomoko Hara
    Department of Internal Medicine, Tokushima Prefecture Hospital of Kaifu, Kaifu County, Tokushima, Japan
    Int J Hematol 79:157-60. 2004
    ....
  46. ncbi request reprint Molecular mechanism of type I congenital heparin cofactor (HC) II deficiency caused by a missense mutation at reactive P2 site: HC II Tokushima
    Y Kanagawa
    First Department of Internal Medicine, University of Tokushima School of Medicine, Japan
    Thromb Haemost 85:101-7. 2001
    ..We conclude that the impaired secretion of the mutant HC II molecules, due to intracellular degradation, is the molecular pathogenesis of type I congenital HC II deficiency caused by a Pro443 to Leu mutation at reactive P2 site...
  47. doi request reprint [Myeloma bone disease and RANKL signaling]
    Masahiro Abe
    Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Medicine, Japan
    Clin Calcium 21:1167-74. 2011
    ..Given formation of vicious cycle between bone destruction and tumor progression, inhibiting RANKL signaling may also contribute to the suppression of myeloma expansion...
  48. ncbi request reprint Role for macrophage inflammatory protein (MIP)-1alpha and MIP-1beta in the development of osteolytic lesions in multiple myeloma
    Masahiro Abe
    First Department of Internal Medicine, School of Medicine, Department of Orthodontics, School of Dentistry, University of Tokushima, 3 18 15 Kuramoto cho, Tokushima 770 8503, Japan
    Blood 100:2195-202. 2002
    ..These results suggest that MIP-1alpha and MIP-1beta may be major osteoclast-activating factors produced by MM cells...
  49. ncbi request reprint Emergence of cephem- and aztreonam-high-resistant Neisseria gonorrhoeae that does not produce beta-lactamase
    S Akasaka
    Department of Urology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan
    J Infect Chemother 7:49-50. 2001
    ..Therefore, in Japan, patients with gonococcal urethritis caused by these resistant N. gonorrhoeae strains should be treated with cefodizime or spectinomycin...
  50. ncbi request reprint No increased risk of thrombosis in heterozygous congenital dysplasminogenemia
    T Shigekiyo
    First Department of Internal Medicine, School of Medicine, The University of Tokushima, Japan
    Int J Hematol 72:247-52. 2000
    ..32) or Cox-Mantel test (P = .62). These findings suggest that heterozygous congenital dysplasminogenemia is not associated with an increased risk of thrombosis...
  51. doi request reprint Targeting myeloma-osteoclast interaction with Vγ9Vδ2 T cells
    Qu Cui
    Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Medicine, 3 18 15 Kuramoto, Tokushima, 770 8503, Japan
    Int J Hematol 94:63-70. 2011
    ..These results suggest that Vγ9Vδ2 T cells expanded by zoledronic acid and IL-2 are able to migrate to MM bone lesions and preferentially target OCs as well as MM cells, thereby inhibiting both tumor expansion and bone destruction...
  52. doi request reprint Increasing incidence of elderly onset patients with myasthenia gravis in a local area of Japan
    N Matsui
    Department of Neurology, Institute of Health Bioscience, Tokushima University Graduate School of Medicine, Tokushima, Japan
    J Neurol Neurosurg Psychiatry 80:1168-71. 2009
    ..As the number of elderly patients with myasthenia gravis (MG) has recently increased in Europe and the USA, a retrospective survey of Japanese MG patients was conducted in a single neurological centre over several decades...
  53. ncbi request reprint Endothelin-1 promotes vascular structural remodeling during the progression of heart failure prevention of vascular remodeling using a specific endothelin-converting enzyme inhibitor
    X Wang
    First Department of Internal Medicine, Shiga University of Medical Science, Otsu, Japan
    Life Sci 69:2477-88. 2001
    ..05). In conclusion, ET-1 plays a critical role in the structural deterioration of the vasculature during the progression of CHF, and ECE inhibitors can prevent the development of vascular remodeling...
  54. ncbi request reprint Corticospinal tract involvement in a variant of Guillain-Barré syndrome
    Y Oshima
    First Department of Internal Medicine, School of Medicine, University of Tokushima, Kuramoto 3-18-15, Tokushima 770-8503, Japan
    Eur Neurol 46:39-42. 2001
    ..001). Although hyperreflexia is a controversial symptom in patients with GBS, these findings indicate that there is functional corticospinal tract involvement in patients with a GBS variant...
  55. pmc Mutations producing premature termination of translation and an amino acid substitution in the sterol 27-hydroxylase gene cause cerebrotendinous xanthomatosis associated with parkinsonism
    N Wakamatsu
    First Department of Internal Medicine, School of Medicine, The University of Tokushima, Tokushima, Japan
    J Neurol Neurosurg Psychiatry 67:195-8. 1999
    ..Mutational analysis of the sterol 27-hydroxylase (CYP27) gene was performed on three patients from two Japanese families who had cerebrotendinous xanthomatosis (CTX) associated with parkinsonism...
  56. doi request reprint The serine/threonine kinase Pim-2 is a novel anti-apoptotic mediator in myeloma cells
    J Asano
    Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Medicine, Tokushima, Japan
    Leukemia 25:1182-8. 2011
    ..The Pim inhibitor suppresses 4E-BP1 phosphorylation along with the reduction of Mcl-1 and c-Myc. Pim-2 may therefore become a new target for MM treatment...
  57. doi request reprint Assessment of vertebral fracture risk and therapeutic effects of alendronate in postmenopausal women using a quantitative computed tomography-based nonlinear finite element method
    K Imai
    Department of Orthopaedic Surgery, School of Medicine, The University of Tokyo, Tokyo, Japan
    Osteoporos Int 20:801-10. 2009
    ..It had higher discriminatory power for vertebral fracture than aBMD and vBMD. Alendronate effects were detected at 3 months, and marked bone density increases were noted in juxta-cortical areas compared to inner trabecular areas...
  58. pmc Glycolysis inhibition inactivates ABC transporters to restore drug sensitivity in malignant cells
    Ayako Nakano
    Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Medicine, Tokushima, Japan
    PLoS ONE 6:e27222. 2011
    ....
  59. ncbi request reprint Two possible mechanisms underlying nitrate tolerance in monkey coronary arteries
    T Omura
    First Department of Internal Medicine, Shiga University of Medical Science, Seta, Otsu, Japan
    Clin Exp Pharmacol Physiol 28:259-65. 2001
    ..3. As a mechanism of NTG tolerance, two possible processes may be impaired: (i) biotransformation from NTG to NO; and (ii) an intracellular process that occurs after the synthesis of cGMP...
  60. ncbi request reprint NAT2 gene polymorphism as a possible marker for susceptibility to bladder cancer in Japanese
    H Inatomi
    Department of Urology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Int J Urol 6:446-54. 1999
    ..There are significant interethnic differences in NAT2 allele frequencies. The relationship between NAT2 genotypes and bladder cancer in a Japanese population was investigated...
  61. ncbi request reprint Effects of peripheral nerve stimulation on the blood flow of the spinal cord and the nerve root
    K Takahashi
    Department of Orthopaedic Surgery, School of Medicine, University of Kanazawa, Ishikawa, Japan
    Spine (Phila Pa 1976) 13:1278-83. 1988
    ..In the spinal cord, an increase of the local metabolic rate appeared to be important for the blood flow increase. In the nerve root, the sympathetic nerves may have an important effect in the blood flow increase...
  62. ncbi request reprint Critical timing of mitochondrial K(ATP) channel opening for enhancement of myocardial tolerance against infarction
    A Tsuchida
    Second Department of Internal Medicine, Sapporo Medical University, School of Medicine, Japan
    Basic Res Cardiol 96:446-53. 2001
    ..The present study was designed to assess the relationship between the timing of a mitoK(ATP) channel opener, diazoxide, and its infarct size-limiting effect...
  63. ncbi request reprint Dermatomyositis associated with impairment in both muscle aerobic and anaerobic function
    M Kunishige
    Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Medicine, Tokushima, Japan
    Clin Neuropathol 24:32-5. 2005
    ..These findings indicate that an inflammatory mechanism interfered with myophosphorylase activity and muscle aerobic function...
  64. ncbi request reprint Diagnosis of retrovesical ectopic and hyperplastic prostate tissue by transrectal needle biopsy
    T Hamasaki
    Department of Urology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan
    Urol Int 66:171-3. 2001
    ..The tumor was histologically confirmed to be a benign prostatic hyperplasia. This is the 3rd case of retrovesical ectopic prostatic tissue which was diagnosed by transrectal needle biopsy...
  65. ncbi request reprint 17beta-estradiol stimulates expression of osteoprotegerin by a mouse stromal cell line, ST-2, via estrogen receptor-alpha
    M Saika
    First Department of Internal Medicine, University of Tokushima School of Medicine, Tokushima, Japan
    Endocrinology 142:2205-12. 2001
    ....
  66. pmc Interleukin-1 beta enhances and interferon-gamma suppresses activin A actions by reciprocally regulating activin A and follistatin secretion from bone marrow stromal fibroblasts
    M Abe
    First Department of Internal Medicine, School of Medicine, University of Tokushima, Tokushima, Japan
    Clin Exp Immunol 126:64-8. 2001
    ..The present results also suggest that the inhibitory effect of IFN-gamma on erythropoiesis is mediated at least in part by a suppression of activin A actions in bone marrow...
  67. ncbi request reprint Successful combination therapy--flunarizine, pentoxifylline, and cholestyramine--for spur cell anemia
    K Aihara
    First Department of Internal Medicine, University of Tokushima School of Medicine, Japan
    Int J Hematol 73:351-5. 2001
    ..These observations suggest that non-invasive combination therapy with flunarizine, pentoxifylline, and cholestyramine is effective and valuable in the treatment of patients with spur cell anemia...
  68. ncbi request reprint Mesangial proliferative glomerulonephritis with deposits of anti-nicotinic acetylcholine receptor antibody in a patient with myasthenia gravis
    T Mitsui
    First Department of Internal Medicine, School of Medicine, The University of Tokushima, Kuramoto-3, Tokushima, 770-8503, Japan
    J Clin Neurosci 8:454-6. 2001
    ....
  69. ncbi request reprint Dermatomyositis associated with Sjögren's syndrome: VEGF involvement in vasculitis
    A Ohno
    Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Medicine, Japan
    Clin Neuropathol 23:178-82. 2004
    ..These findings suggest that VEGF overexpression was associated with the development of vasculopathy in skeletal muscle and salivary glands and possibly in the peripheral nervous system...
  70. ncbi request reprint Systemic muscular inflammation in a patient with recurrent orbital myositis
    H Omori
    Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Medicine, Tokushima, Japan
    Clin Neuropathol 24:191-3. 2005
    ..Quadriceps biopsy showed infiltrates of mononuclear cells around intramuscular vessels and mild degenerative changes in muscle cells. These findings indicate that the present case belongs to the spectrum of localized nodular myositis...
  71. ncbi request reprint Monotypic epithelioid angiomyolipoma of the liver
    S Yamasaki
    Department of First Pathology, Juntendo University, School of Medicine, Tokyo, Japan
    Histopathology 36:451-6. 2000
    ..We report here the first case of monotypic epithelioid angiomyolipoma arising in the liver...
  72. ncbi request reprint Histidine-rich glycoprotein (HRG) Tokushima 2: novel HRG deficiency, molecular and cellular characterization
    T Shigekiyo
    First Department of Internal Medicine, School of Medicine, The University of Tokushima, Japan
    Thromb Haemost 84:675-9. 2000
    ..These results indicate that congenital HRG deficiency caused by a substitution of Cys223 to Arg is hereditary in this family...
  73. pmc Protective effects of a leukotriene inhibitor and a leukotriene antagonist on endotoxin-induced mortality in carrageenan-pretreated mice
    M Ogata
    Department of Anesthesiology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Infect Immun 60:2432-7. 1992
    ..Therefore, both leukotrienes and TNF play important roles in endotoxin-induced shock and mortality...
  74. doi request reprint Induction of endosomal/lysosomal pathways in differentiating osteoblasts as revealed by combined proteomic and transcriptomic analyses
    Takako Taniguchi
    Institute for Enzyme Research, University of Tokushima, Tokushima, Japan
    FEBS Lett 584:3969-74. 2010
    ..Osteoblasts, therefore, are involved not only in the synthesis but also in the turnover of the extracellular matrix proteins such as collagens...
  75. doi request reprint Size-controlled synthesis, surface functionalization, and biological applications of thiol-organosilica particles
    Michihiro Nakamura
    Department of Anatomy and Cell Biology, University of Tokushima Graduate School of Medical Sciences, Tokushima 770 8503, Japan
    Colloids Surf B Biointerfaces 79:19-26. 2010
    ..In this paper, we demonstrated the possibility of size-controlled thiol-organosilica particles for wild range of biological applications...
  76. ncbi request reprint Improvement of cardiac diastolic function and prognosis after autologous peripheral blood stem cell transplantation in AL cardiac amyloidosis
    Shusuke Yagi
    Department of Medicine and Bioregulatory Sciences, Institute of Health Biosciences, The University of Tokushima Graduate School
    Intern Med 46:1705-10. 2007
    ..This treatment resulted in significant improvement in cardiac function and good prognosis for about 3.5 years after the diagnosis. Therefore, auto-PBSCT is a possible option as up-front therapy for AL cardiac amyloidosis...
  77. ncbi request reprint A case of esophageal sarcomatoid carcinoma with molecular evidence of a monoclonal origin
    K Kashiwabara
    Second Department of Pathology, Gunma University, School of Medicine, Japan
    Pathol Res Pract 197:41-6. 2001
    ..Further molecular analysis revealed that the two components had the same somatic mutation in the p53 gene. These results suggest a monoclonal origin of this biphasic tumor...
  78. ncbi request reprint [Long-term survival of hormone-refractory prostate cancer: a case report]
    N Fujimoto
    Department of Urology, School of Medicine, University of Occupational and Environmental Health, Japan, Yahatanishi-ku, Kitakyushu 807-8555, Japan
    J UOEH 23:51-8. 2001
    ..This case indicates that alteration of antiandrogens or oral chemotherapy may be useful in some cases with hormone-refractory prostate cancer...
  79. ncbi request reprint Relationship between plasma levels of cardiac natriuretic peptides and soluble Fas: plasma soluble Fas as a prognostic predictor in patients with congestive heart failure
    T Tsutamoto
    First Department of Internal Medicine, Shiga University of Medical Science, Tsukinowa, Seta, Otsu, Japan
    J Card Fail 7:322-8. 2001
    ..Plasma sFas is a useful prognostic marker independent of neurohumoral factors, suggesting that immune activation and/or apoptosis play a significant role in the pathogenesis of CHF...
  80. ncbi request reprint Detection of denervated but viable myocardium in cardiac sarcoidosis with I-123 MIBG and Tl-201 SPECT imaging
    S Matsuo
    First Department of Internal Medicine, Shiga University of Medical Science, Seta, Otsu, Japan
    Ann Nucl Med 15:373-5. 2001
    ..Cardiac sympathetic nerve function was impaired in cardiac sarcoidosis, slightly improved with steroid therapy. I-123 MIBG scintigraphy may be useful to assess extent of myocardial involvement and response to therapy...
  81. ncbi request reprint Serum YKL-40 levels in rheumatoid arthritis: correlations between clinical and laborarory parameters
    T Matsumoto
    Department of Orthopedic Surgery, Nagasaki University, School of Medicine, Japan
    Clin Exp Rheumatol 19:655-60. 2001
    ..To clarify the significance of YKL-40, also called human cartilage glycoprotein-39, in the serum of patients with RA, we studied serum YKL-40 in relation to clinical and laboratory parameters...
  82. ncbi request reprint Superantigens and autoantigens may be involved in the pathogenesis of gastric mucosa-associated lymphoid tissue lymphoma
    T Hashimoto
    First Department of Internal Medicine, School of Medicine, University of Tokushima, Japan
    Int J Hematol 74:197-204. 2001
    ..Thus, these observations suggest that most gastric MALTLs arise from memory B cells that are preliminarily activated by superantigens and autoantigens...
  83. ncbi request reprint Enhanced expression of osteopontin by high glucose. Involvement of osteopontin in diabetic macroangiopathy
    M Takemoto
    Second Department of Internal Medicine, School of Medicine, Chiba University, Japan
    Ann N Y Acad Sci 902:357-63. 2000
    ..Our results suggest that osteopontin could play a role in the development of diabetic vascular complications...
  84. ncbi request reprint Activation of peroxisome proliferator-activated receptor α in megakaryocytes reduces platelet-derived growth factor-BB in platelets
    Shunji Hashizume
    Department of Medicine and Bioregulatory Sciences, The University of Tokushima Graduate School of Health Biosciences, Tokushima, Japan
    J Atheroscler Thromb 18:138-47. 2011
    ..The objective of this study was to clarify the pleiotropic effect of peroxisome proliferator-activated receptor α (PPARα) activators on PDGF-BB expression in megakaryocytes and platelets...
  85. ncbi request reprint [Successful treatment of relapsed/refractory Hodgkin's lymphoma with tandem transplantation]
    Kana Shichijo
    Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Medicine, Tokushima
    Nihon Naika Gakkai Zasshi 93:2210-2. 2004
  86. doi request reprint [New development in bisphosphonate treatment. Treatment with bisphosphonates for cancer-induced bone disease]
    Masahiro Abe
    University of Tokushima Graduate School of Medicine, Department of Medicine and Bioregulatory Sciences, Japan
    Clin Calcium 19:55-62. 2009
    ..It is important to clarify the clinical impact of long-term bisphosphonate use and make beneficial use of this agent by eliminating underlying risk of its adverse effects...
  87. ncbi request reprint Preferential gray matter involvement in dengue myelitis
    M Kunishige
    Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Medicine, 3 18 15, Kuramoto, Tokushima 770 8503, Japan
    Neurology 63:1980-1. 2004
  88. pmc Central motor conduction in patients with anti-ganglioside antibody associated neuropathy syndromes and hyperreflexia
    Y Oshima
    First Department of Internal Medicine, School of Medicine, The University of Tokushima, Japan
    J Neurol Neurosurg Psychiatry 73:568-73. 2002
    ..The aim of the study was to determine whether hyperreflexia corresponds to corticospinal tract dysfunction in these patients...
  89. ncbi request reprint Recapping T-saw laminoplasty for spinal cord tumors
    N Kawahara
    Department of Orthopaedic Surgery, School of Medicine, Kanazawa University, Japan
    Spine (Phila Pa 1976) 24:1363-70. 1999
    ..A prospective study of patients whose spinal cord tumors were managed surgically with a unique posterior method of removing and replacing the posterior spinal elements using T-saw ("recapping T-saw laminoplasty")...
  90. ncbi request reprint Effects of alendronate on bone metastases and hypercalcemia after surgery for hepatocellular carcinoma
    T Ohnishi
    First Department of Surgery, University of Tokushima, School of Medicine, Japan
    Jpn J Clin Oncol 30:410-3. 2000
    ....
  91. ncbi request reprint Bradykinin stimulates the release of tissue plasminogen activator in human coronary circulation: effects of angiotensin-converting enzyme inhibitors
    K Minai
    First Department of Internal Medicine, Shiga University of Medical Science, Seta Tsukinowa, Otsu, Japan
    J Am Coll Cardiol 37:1565-70. 2001
    ..CONCLUSIONS: Intracoronary infusion of BK stimulates tPA release without causing any change in PAI-1 levels in the human coronary circulation. In addition, this effect of BK is augmented by an ACE inhibitor...
  92. doi request reprint Different effect of acute treatment with rosiglitazone on rat myocardial ischemia/reperfusion injury by administration method
    Masahiro Abe
    Department of Clinical Pharmacology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    Eur J Pharmacol 589:215-9. 2008
    ..However, acute treatment with rosiglitazone is harmful if its concentration is high during ischemia...
  93. ncbi request reprint Extramedullary plasmacytoma immunoglobulin D (lambda) in the chest wall and the subglottic region
    Shoji Sakiyama
    Department of Oncological Surgery, Graduate School of Medicine, University of Tokushima, Kuramoto Cho 3, Tokushima 770 8503, Japan
    J Thorac Cardiovasc Surg 129:1168-9. 2005
  94. ncbi request reprint Potent induction of activin A secretion from monocytes and bone marrow stromal fibroblasts by cognate interaction with activated T cells
    Masahiro Abe
    First Department of Internal Medicine, School of Medicine, University of Tokushima, Japan
    J Leukoc Biol 72:347-52. 2002
    ..These findings suggest that activin A is potently induced in the bone marrow and may play a role in the suppression of inflammatory or immune processes...
  95. ncbi request reprint Contribution of neutrophils to lipopolysaccharide-induced tumor necrosis factor production and mortality in a carrageenan-pretreated mouse model
    T Matsumoto
    Department of Anesthesiology, School of Medicine, University of Occupational and Environmental Health, Japan, Fukuoka, Japan
    FEMS Immunol Med Microbiol 17:171-8. 1997
    ..We suggest that neutrophils are the major cells to produce TNF-alpha and to determine mouse mortality after LPS challenge in the mouse CAR model...
  96. ncbi request reprint Aggressive antiplatelet therapy before coronary stent implantation in acute coronary syndrome with essential thrombocythemia--a case report
    Mitsunori Fujimura
    First Department of Internal Medicine, University of Tokushima School of Medicine, Kuramoto 3 18 15, Tokushima 770 8503, Japan
    Angiology 54:485-90. 2003
    ....