Toshiya Masuda

Summary

Affiliation: The University of Tokushima
Country: Japan

Publications

  1. ncbi request reprint Radical scavenging activity of spring mountain herbs in the Shikoku mountain area and identification of antiradical constituents by simple HPLC detection and LC-MS methods
    Toshiya Masuda
    Graduate School of Integrated Arts and Sciences, University of Tokushima, Tokushima, Japan
    Biosci Biotechnol Biochem 76:705-11. 2012
  2. ncbi request reprint Structural identification of new curcumin dimers and their contribution to the antioxidant mechanism of curcumin
    Toshiya Masuda
    Faculty of Integrated Arts and Sciences, University of Tokushima, Tokushima 770 8502, Japan
    J Agric Food Chem 50:2524-30. 2002
  3. ncbi request reprint Recovery mechanism of the antioxidant activity from carnosic acid quinone, an oxidized sage and rosemary antioxidant
    Toshiya Masuda
    Faculty of Integrated Arts and Sciences, University of Tokushima, Tokushima 770 8502, Japan
    J Agric Food Chem 50:5863-9. 2002
  4. ncbi request reprint Phenolic inhibitors of chemical and enzymatic oxidation in the leaves of Myrica rubra
    Toshiya Masuda
    Graduate School of Integrated Arts and Sciences, University of Tokushima, Japan
    Biosci Biotechnol Biochem 74:212-5. 2010
  5. ncbi request reprint Cytotoxic screening of medicinal and edible plants in Okinawa, Japan, and identification of the main toxic constituent of Rhodea japonica (Omoto)
    Toshiya Masuda
    Faculty of Integrated Arts and Sciences, University of Tokushima, Tokushima 770 8502, Japan
    Biosci Biotechnol Biochem 67:1401-4. 2003
  6. ncbi request reprint Recovery of antioxidant activity from carnosol quinone: antioxidants obtained from a water-promoted conversion of carnosol quinone
    Toshiya Masuda
    Faculty of Integrated Arts and Sciences, University of Tokushima, Tokushima 770 8502, Japan
    J Agric Food Chem 53:6831-4. 2005
  7. ncbi request reprint Identification of the antioxidation reaction products from a sinapic ester in a lipid oxidation system
    Toshiya Masuda
    Faculty of Integrated Arts and Sciences, University of Tokushima, Tokushima, Japan
    Biosci Biotechnol Biochem 73:736-9. 2009
  8. ncbi request reprint Screening for tyrosinase inhibitors among extracts of seashore plants and identification of potent inhibitors from Garcinia subelliptica
    Toshiya Masuda
    Faculty of Integrated Arts and Sciences, University of Tokushima, Tokushima, Japan
    Biosci Biotechnol Biochem 69:197-201. 2005
  9. doi request reprint Antioxidation mechanism studies of caffeic acid: identification of antioxidation products of methyl caffeate from lipid oxidation
    Toshiya Masuda
    Faculty of Integrated Arts and Sciences, University of Tokushima, Tokushima 770 8502, Japan
    J Agric Food Chem 56:5947-52. 2008
  10. ncbi request reprint Identification of geranic acid, a tyrosinase inhibitor in lemongrass (Cymbopogon citratus)
    Toshiya Masuda
    Faculty of Integrated Arts and Sciences, University of Tokushima, Tokushima 770 8502, Japan
    J Agric Food Chem 56:597-601. 2008

Collaborators

Detail Information

Publications53

  1. ncbi request reprint Radical scavenging activity of spring mountain herbs in the Shikoku mountain area and identification of antiradical constituents by simple HPLC detection and LC-MS methods
    Toshiya Masuda
    Graduate School of Integrated Arts and Sciences, University of Tokushima, Tokushima, Japan
    Biosci Biotechnol Biochem 76:705-11. 2012
    ..The material evidence for the potent activity of the extracts was studied by a combination of our developed method for detecting antiradical compounds, LC-MS/MS, and enzymatic hydrolysis...
  2. ncbi request reprint Structural identification of new curcumin dimers and their contribution to the antioxidant mechanism of curcumin
    Toshiya Masuda
    Faculty of Integrated Arts and Sciences, University of Tokushima, Tokushima 770 8502, Japan
    J Agric Food Chem 50:2524-30. 2002
    ..The A-A termination (dimer formation) was estimated to contribute at least about 40% of the entire antioxidant process against ethyl linoleate oxidation...
  3. ncbi request reprint Recovery mechanism of the antioxidant activity from carnosic acid quinone, an oxidized sage and rosemary antioxidant
    Toshiya Masuda
    Faculty of Integrated Arts and Sciences, University of Tokushima, Tokushima 770 8502, Japan
    J Agric Food Chem 50:5863-9. 2002
    ..This proposed mechanism can explain one of the reasons for the strong antioxidant activity of the extract of the popular herbs sage and rosemary...
  4. ncbi request reprint Phenolic inhibitors of chemical and enzymatic oxidation in the leaves of Myrica rubra
    Toshiya Masuda
    Graduate School of Integrated Arts and Sciences, University of Tokushima, Japan
    Biosci Biotechnol Biochem 74:212-5. 2010
    ..The obtained data indicate that the chemical and enzymatic (lipoxygenase and tyrosinase) antioxidant activities of the leaves mainly depended on the galloyl flavonoid derivatives...
  5. ncbi request reprint Cytotoxic screening of medicinal and edible plants in Okinawa, Japan, and identification of the main toxic constituent of Rhodea japonica (Omoto)
    Toshiya Masuda
    Faculty of Integrated Arts and Sciences, University of Tokushima, Tokushima 770 8502, Japan
    Biosci Biotechnol Biochem 67:1401-4. 2003
    ..The IC(50) value for rhodexin A against the growth of K562 cells was 19 nM, this activity being much stronger than that of ouabain (IC(50), 60 nM)...
  6. ncbi request reprint Recovery of antioxidant activity from carnosol quinone: antioxidants obtained from a water-promoted conversion of carnosol quinone
    Toshiya Masuda
    Faculty of Integrated Arts and Sciences, University of Tokushima, Tokushima 770 8502, Japan
    J Agric Food Chem 53:6831-4. 2005
    ..At the same time, carnosol quinone was reduced to afford carnosol. This redox phenomenon is an important part of the mechanism for the recovery of the antioxidant activity from carnosol quinone under the water-containing conditions...
  7. ncbi request reprint Identification of the antioxidation reaction products from a sinapic ester in a lipid oxidation system
    Toshiya Masuda
    Faculty of Integrated Arts and Sciences, University of Tokushima, Tokushima, Japan
    Biosci Biotechnol Biochem 73:736-9. 2009
    ....
  8. ncbi request reprint Screening for tyrosinase inhibitors among extracts of seashore plants and identification of potent inhibitors from Garcinia subelliptica
    Toshiya Masuda
    Faculty of Integrated Arts and Sciences, University of Tokushima, Tokushima, Japan
    Biosci Biotechnol Biochem 69:197-201. 2005
    ..One of these biflavonoids (2R,3S-5,7,4',5'',7'',3''',4'''-heptahydroxy flavanone[3-8''] flavone) showed much stronger activity (IC50 2.5 microM) than that of kojic acid (IC50 9.1 microM) when L-tyrosine was used as the substrate...
  9. doi request reprint Antioxidation mechanism studies of caffeic acid: identification of antioxidation products of methyl caffeate from lipid oxidation
    Toshiya Masuda
    Faculty of Integrated Arts and Sciences, University of Tokushima, Tokushima 770 8502, Japan
    J Agric Food Chem 56:5947-52. 2008
    ..On the basis of the formation pathway of these products, an antioxidation reaction mechanism of methyl caffeate, including the redox reaction of the caffeate and Diels-Alder reaction of the produced peroxides, was proposed...
  10. ncbi request reprint Identification of geranic acid, a tyrosinase inhibitor in lemongrass (Cymbopogon citratus)
    Toshiya Masuda
    Faculty of Integrated Arts and Sciences, University of Tokushima, Tokushima 770 8502, Japan
    J Agric Food Chem 56:597-601. 2008
    ..14 and 2.3 mM, respectively. The structure requirement of geranic acid for the potent tyrosinase inhibitory activity was investigated using geranic acid-related compounds...
  11. ncbi request reprint Tyrosinase inhibitory activity of ethanol extracts from medicinal and edible plants cultivated in okinawa and identification of a water-soluble inhibitor from the leaves of Nandina domestica
    Toshiya Masuda
    Faculty of Integrated Arts and Sciences, University of Tokushima, Tokushima 770 8502, Japan
    Biosci Biotechnol Biochem 71:2316-20. 2007
    ..Although it was a known compound (4-beta-D-glucopyranosyloxybenzoic acid), its inhibitory activity toward tyrosinase is revealed for the first time in this work...
  12. ncbi request reprint Flow cytometric estimation on cytotoxic activity of leaf extracts from seashore plants in subtropical Japan: isolation, quantification and cytotoxic action of (-)-deoxypodophyllotoxin
    Toshiya Masuda
    Faculty of Integrated Arts and Sciences, University of Tokushima, Tokushima 770 8502, Japan
    Phytother Res 16:353-8. 2002
    ..The results indicate that DPT contributes to the cytotoxic action of the extract from the leaves of H. nymphaeaefolia on K562 cells...
  13. ncbi request reprint Antioxidant mechanism studies on ferulic acid: identification of oxidative coupling products from methyl ferulate and linoleate
    Toshiya Masuda
    Faculty of Integrated Arts and Sciences, University of Tokushima, Japan
    J Agric Food Chem 54:6069-74. 2006
    ..The produced peroxides subsequently underwent intramolecular Diels-Alder reaction to afford stable tricyclic peroxides...
  14. ncbi request reprint Antioxidant mechanism of carnosic acid: structural identification of two oxidation products
    T Masuda
    Faculty of Integrated Arts and Sciences, University of Tokushima, Tokushima 770 8502, Japan
    J Agric Food Chem 49:5560-5. 2001
    ....
  15. ncbi request reprint Chemical studies on antioxidant mechanism of curcuminoid: analysis of radical reaction products from curcumin
    T Masuda
    Faculty of Integrated Arts and Sciences, University of Tokushima, Tokushima 770 8502, Japan
    J Agric Food Chem 47:71-7. 1999
    ..The time course and gel permeation chromatography studies of the reaction were also investigated, and the results indicate that the dimer is a radical-terminated product in the initial stage...
  16. ncbi request reprint Isolation and antioxidant activity of galloyl flavonol glycosides from the seashore plant, Pemphis acidula
    T Masuda
    Faculty of Integrated Arts and Sciences, University of Tokushima, Japan
    Biosci Biotechnol Biochem 65:1302-9. 2001
    ..The galloyl flavonoids showed more efficient activity than that of the corresponding flavonol glycosides, but not more than that of the corresponding aglycones in the three assays applied...
  17. ncbi request reprint Chemical studies on antioxidant mechanism of curcumin: analysis of oxidative coupling products from curcumin and linoleate
    T Masuda
    Faculty of Integrated Arts and Sciences, University of Tokushima, Tokushima 770 8502, Japan
    J Agric Food Chem 49:2539-47. 2001
    ....
  18. ncbi request reprint Evaluation of the antioxidant activity of environmental plants: activity of the leaf extracts from seashore plants
    T Masuda
    Faculty of Integrated Arts and Sciences, University of Tokushima, Japan
    J Agric Food Chem 47:1749-54. 1999
    ..The HPLC analysis of the extracts indicated the presence of the same antioxidant and isolation work for the compound identified ellagic acid. The isolated ellagic acid showed strong antioxidant activity in the assay systems used...
  19. ncbi request reprint Isolation and structure determination of new antioxidative ferulic acid glucoside esters from the rhizome of Alpinia speciosa, a Zingiberaceae plant used in Okinawan food culture
    T Masuda
    Tropical Biosphere Research Center, University of Ryukyus, Taketomi, Okinawa 907 1541, Japan
    J Agric Food Chem 48:1479-84. 2000
    ..Both compounds showed greater activity than that of Trolox in the TLC method; however, one of the compounds showed weaker inhibitory activity than that of Trolox and epicatechin against AMVN-induced methyl linoleate oxidation...
  20. ncbi request reprint Simple detection method of powerful antiradical compounds in the raw extract of plants and its application for the identification of antiradical plant constituents
    Toshiya Masuda
    Faculty of Integrated Arts and Sciences, University of Tokushima, Tokushima 770 8502, Japan
    J Agric Food Chem 51:1831-8. 2003
    ..The radical scavenging efficiency of a newly identified compound from H. chinense was also compared with that of Trolox and catechin using the method...
  21. ncbi request reprint Flow cytometric estimation of cytotoxic activity of rhodexin A isolated from Rhodea japonica in human leukemia K562 cells
    Chisato Umebayashi
    Laboratories of Cell Signaling and Bioorganic Chemistry, Faculty of Integrated Arts and Sciences, The University of Tokushima, Japan
    Biol Pharm Bull 26:627-30. 2003
    ..Rhodexin A may also be a candidate for cancer treatment because there have been clinical reports of tumor regression in patients taking cardiac glycosides...
  22. doi request reprint Apoptosis-inducing action of two products from oxidation of sesamol, an antioxidative constituent of sesame oil: a possible cytotoxicity of oxidized antioxidant
    Aya Fujimoto
    Laboratories of Bioorganic Chemistry and Cellular Signaling, Faculty of Integrated Arts and Sciences, The University of Tokushima, Tokushima, Japan
    Toxicol In Vitro 24:1720-6. 2010
    ..It may be necessary to consider the condition for preservation of sesamol and the safety of products from in vivo oxidation of sesamol for human health...
  23. doi request reprint A novel ring-expanded product with enhanced tyrosinase inhibitory activity from classical Fe-catalyzed oxidation of rosmarinic acid, a potent antioxidative Lamiaceae polyphenol
    Aya Fujimoto
    Graduate School of Integrated Arts and Sciences, University of Tokushima, Tokushima, Japan
    Bioorg Med Chem Lett 20:7393-6. 2010
    ..The formation mechanism of the unique ring structure from the catechol part of the rosmarinic acid was proposed...
  24. doi request reprint Glycosidic constituents of the leaves of an Okinawan Leguminosae plant, Derris trifoliata Lour
    Yoshio Takeda
    Faculty of Integrated Arts and Sciences, The University of Tokushima, 1 1 Minamijosanjima cho, Tokushima, 770 8502, Japan
    J Nat Med 62:476-8. 2008
    ..From the leaves of Derris trifoliata, collected in Okinawa, 15 glycosidic compounds were isolated and identified...
  25. ncbi request reprint Cytotoxic activity of maytanprine isolated from Maytenus diversifolia in human leukemia K562 cells
    Hiromi Nakao
    Laboratories of Cell Signaling and Bioorganic Chemistry, Faculty of Integrated Arts and Sciences, The University of Tokushima, Tokushima, Japan
    Biol Pharm Bull 27:1236-40. 2004
    ..The results suggest that maytanprine exerts a potent inhibitory action on the growth of human leukemia K562 cells. M. diversifolia is one natural source of maytanprine, which is more cytotoxic than maytansine...
  26. doi request reprint Cytometric analysis on cytotoxicity of curcumin on rat thymocytes: Proapoptotic and antiapoptotic actions of curcumin
    Kazuki Koizumi
    Laboratory of Cellular Signaling, Faculty of Integrated Arts and Sciences, The University of Tokushima, Tokushima 770 8502, Japan
    Toxicol In Vitro 25:985-90. 2011
    ..5% ethanol increased the population of shrunken cells. It is likely that curcumin at 5 μM or more exerts cytotoxic action on normal cells although many studies show some anticancer actions of curcumin at 10 μM or more on cancer cells...
  27. doi request reprint Cytometric analysis of cytotoxicity of polyphenols and related phenolics to rat thymocytes: potent cytotoxicity of resveratrol to normal cells
    Aya Fujimoto
    Laboratory of Cellular Signaling, Faculty of Integrated Arts and Sciences, University of Tokushima, Tokushima 770 8502, Japan
    Basic Clin Pharmacol Toxicol 104:455-62. 2009
    ..Thus, at concentrations that are suitable for chemopreventive and chemotherapeutic actions, resveratrol may exert a cytotoxic effect on normal cells...
  28. ncbi request reprint Lasianthionosides A-C, megastigmane glucosides from leaves of Lasianthus fordii
    Yoshio Takeda
    Faculty of Integrated Arts and Sciences, The University of Tokushima, 1 1 Minamijosanjima cho, Tokushima 770 8502, Japan
    Phytochemistry 65:485-9. 2004
    ..The structures have been elucidated based on spectroscopic analyses and/or X-ray crystallographic analysis...
  29. ncbi request reprint Enhancing effect of a cysteinyl thiol on the antioxidant activity of flavonoids and identification of the antioxidative thiol adducts of myricetin
    Toshiya Masuda
    Graduate School of Integrated Arts and Sciences, University of Tokushima
    Biosci Biotechnol Biochem 77:1753-8. 2013
    ..The obtained data indicated that two thiol adducts on the B ring, and probably C-ring adducts, which were produced in the antioxidation process, exerted an enhancing effect on the antioxidant activity of myricetin. ..
  30. ncbi request reprint C,O-bisglycosylapigenins from the leaves of Rhamnella inaequilatera
    Yoshio Takeda
    Faculty of Integrated Arts and Sciences, The University of Tokushima, 1 1, Minamijosanjima, Tokushima 770 8502, Japan
    Phytochemistry 65:463-8. 2004
    ..From the leaves of Rhamnella inaequilatera, three flavone C,O-bisglycosides, rhamnellaflavosides A, B and C, were isolated and their structures were elucidated based on their spectral data and chemical evidence...
  31. ncbi request reprint New curcuminoids isolated from Zingiber cassumunar protect cells suffering from oxidative stress: a flow-cytometric study using rat thymocytes and H2O2
    T Nagano
    Laboratory of Cellular Signaling, Faculty of Integrated Arts and Sciences, The University of Tokushima, Japan
    Jpn J Pharmacol 75:363-70. 1997
    ..It is suggested that cassumunins A and B may possess a potent protective action on living cells suffering from oxidative stress...
  32. doi request reprint Structure and function of the oxidation products of polyphenols and identification of potent lipoxygenase inhibitors from Fe-catalyzed oxidation of resveratrol
    Yoshimi Shingai
    Graduate School of Integrated Arts and Sciences, University of Tokushima, Tokushima, Japan
    J Agric Food Chem 59:8180-6. 2011
    ..It should be noted that resveratrol had almost no lipoxygenase inhibitory activity, contrary to some researchers' findings...
  33. ncbi request reprint Lanceocrepidiasides A-F, glucosides of guaiane-type sesquiterpene from Crepidiastrum lanceolatum
    Yoshio Takeda
    Faculty of Integrated Arts and Sciences, The University of Tokushima, 1 1 Minamijosanjima cho, Tokushima 770 8502, Japan
    Phytochemistry 66:727-32. 2005
    ..Structures were elucidated by spectroscopic analyses...
  34. ncbi request reprint Identification of cytotoxic dimers in oxidation product from sesamol, a potent antioxidant of sesame oil
    Toshiya Masuda
    Graduate School of Integrated Arts and Sciences, University of Tokushima, Tokushima 770 8502, Japan
    J Agric Food Chem 58:10880-5. 2010
    ..Compound 2 showed the most potent cytotoxic activity among them. Compound 2 has a typical conjugated carbonyl moiety and the moiety possibly contributes to its high toxicity from a structure-activity point of view. ..
  35. ncbi request reprint Chemical evidence for the synergistic effect of a cysteinyl thiol on the antioxidant activity of caffeic and dihydrocaffeic esters
    Aya Fujimoto
    Graduate School of Integrated Arts and Sciences, University of Tokushima, Tokushima 770 8502, Japan
    Food Chem 138:1483-92. 2013
    ..The analytical results clarified that the mono-thiol adduct of methyl caffeate and the mono- and di-thiol adducts of methyl dihydrocaffeate contributed to the synergism in the antioxidant activity of both caffeates...
  36. doi request reprint Chemical interaction between polyphenols and a cysteinyl thiol under radical oxidation conditions
    Aya Fujimoto
    Graduate School of Integrated Arts and Science, University of Tokushima, Tokushima 770 8502, Japan
    J Agric Food Chem 60:5142-51. 2012
    ..The mechanism for the thiol addition was discussed on the basis of the structures of the products...
  37. doi request reprint A new phenolic glucoside from an Uzbek medicinal plant, Origanum tyttanthum
    Yoshio Takeda
    Faculty of Integrated Arts and Sciences, The University of Tokushima, 1 1 Minamijosanjima cho, Tokushima, 770 8502, Japan
    J Nat Med 62:71-4. 2008
    ..The structure of the new compound was elucidated as 4-O-beta-D-glucopyranosylbenzyl-3'-hydroxyl-4'-methoxybenzoate (1) based on the spectral and chemical evidence...
  38. ncbi request reprint Reciprocal effects of glucose on the process of cell death induced by calcium ionophore or H2O2 in rat lymphocytes
    Kanna Horimoto
    Laboratories of Cell Signaling and Bioorganochemistry, Faculty of Integrated Arts and Sciences, The University of Tokushima, Tokushima 770 8502, Japan
    Toxicology 225:97-108. 2006
    ..The order in the reactivity cannot explain the protective action of glucose. Glucose at high concentrations exerts reciprocal actions on the process of cell death induced by the oxidative stress and excessive increase in [Ca(2+)](i)...
  39. doi request reprint Metmyoglobin reduction by polyphenols and mechanism of the conversion of metmyoglobin to oxymyoglobin by quercetin
    Miyuki Inai
    Graduate School of Integrated Arts and Sciences, University of Tokushima, Tokushima 770 8502, Japan
    J Agric Food Chem 62:893-901. 2014
    ..This suggested the importance of a high propensity toward reduction of the flavonol structure and rapid convertibility of the quinone form to the phenol form for the MbO2 reduction and the maintenance of the level of MbO2 produced. ..
  40. doi request reprint Identification of a potent xanthine oxidase inhibitor from oxidation of caffeic acid
    Toshiya Masuda
    Graduate School of Integrated Arts and Sciences, University of Tokushima, Tokushima 770 8502, Japan Electronic address
    Free Radic Biol Med 69:300-7. 2014
    ....
  41. doi request reprint Effect of polyphenols on oxymyoglobin oxidation: prooxidant activity of polyphenols in vitro and inhibition by amino acids
    Toshiya Masuda
    Graduate School of Integrated Arts and Sciences, University of Tokushima, Tokushima 770 8502, Japan
    J Agric Food Chem 61:1097-104. 2013
    ....
  42. ncbi request reprint Curcumin: from chemistry to chemistry-based functions
    Akiko Jitoe-Masuda
    Faculty of Human Life Science, Shikoku University, Tokushima, Japan
    Curr Pharm Des 19:2084-92. 2013
    ..Various chemical reactions of curcumin, such as photo-oxidation, enzymatic oxidation, etc. are also summarized. In particular, antioxidation of curcumin in lipid media is introduced as a reaction unique to curcumin...
  43. ncbi request reprint New megastigmane and tetraketide from the leaves of Euscaphis japonica
    Y Takeda
    Faculty of Integrated Arts and Sciences, The University of Tokushima, Japan
    Chem Pharm Bull (Tokyo) 48:752-4. 2000
    ..New megastigmane (1) and tetraketide (2) were isolated from the leaves of Euscaphis japonica and the structures were elucidated by means of spectroscopic and chemical evidence...
  44. ncbi request reprint Protective actions of 5'-n-alkylated curcumins on living cells suffering from oxidative stress
    Y Oyama
    Laboratory of Cellular Signaling, Faculty of Integrated Arts and Sciences, The University of Tokushima, Japan
    Eur J Pharmacol 360:65-71. 1998
    ..Further increases in the length of hydrocarbon chains (up to n-C19H39) of 5'-n-alkylated curcumins greatly attenuated their protective actions by reducing their permeation into the cells...
  45. ncbi request reprint Labdane diterpenoids from Marrubium globosum ssp. globosum
    Y Takeda
    Faculty of Integrated Arts and Sciences, The University of Tokushima, Japan
    Chem Pharm Bull (Tokyo) 48:1234-5. 2000
    ..globosum together with the known diterpenoids, marrubiin and marrubinone B. The structure of this new compound was elucidated by spectral methods...
  46. ncbi request reprint Phlomisflavosides A and B, new flavonol bisglycosides from Phlomis spinidens
    Y Takeda
    Faculty of Integrated Arts and Sciences, The University of Tokushima, Japan
    Chem Pharm Bull (Tokyo) 49:1039-41. 2001
    ..The structures of the new compounds were elucidated based on spectral and chemical evidence...
  47. ncbi request reprint Synthesis of (+/-)-cassumunins A and B, new curcuminoid antioxidants having protective activity of the living cell against oxidative damage
    T Masuda
    Faculty of Integrated Arts and Sciences, University of Tokushima, Tokushima 770, Japan
    J Nat Prod 61:609-13. 1998
    ..The synthetic cassumunins showed stronger protective activity than curcumin against oxidative cell death induced by hydrogen peroxide in a rat thymocyte system...
  48. ncbi request reprint An iridoid glucoside dimer and a non-glycosidic iridoid from the leaves of Lasianthus wallichii
    Yoshio Takeda
    Faculty of Integrated Arts and Sciences, The University of Tokushima, Japan
    Chem Pharm Bull (Tokyo) 50:1395-7. 2002
    ..The structures of the new compounds were elucidated by spectroscopic and chemical evidence...
  49. ncbi request reprint Synthesis and antioxidant activity of oxygenated furofuran lignans
    Satoshi Yamauchi
    Faculty of Agriculture, Ehime University
    Biosci Biotechnol Biochem 68:183-92. 2004
    ..It was found that the tertiary hydroxy group on the furofuran ring affected the degree of antioxidant activity and that the structure, except for the phenolic part, was important for the antioxidant activity...
  50. ncbi request reprint Effect of the benzylic structure of lignan on antioxidant activity
    Satoshi Yamauchi
    Faculty of Agriculture, Ehime University, 3 5 7 Tarumi, Matsuyama, Ehime 790 8566, Japan
    Biosci Biotechnol Biochem 71:2283-90. 2007
    ..Optically active verrucosin (4) was synthesized for the first time in this experiment...
  51. ncbi request reprint Effect of benzylic oxygen on the antioxidant activity of phenolic lignans
    Satoshi Yamauchi
    Faculty of Agriculture, Ehime University, Tarumi 3 5 7, Matsuyama, Ehime 790 8566, Japan
    J Nat Prod 68:1459-70. 2005
    ..In this investigation, stereoisomers of the (benzyl)(hydroxybenzyl)tetrahydrofurans 3 and 4 and liovils 7 and 8 were synthesized for the first time...
  52. ncbi request reprint Synthesis and antioxidant activity of olivil-type lignans
    Satoshi Yamauchi
    Faculty of Agriculture, Ehime University, Ehime, Japan
    Biosci Biotechnol Biochem 69:113-22. 2005
    ..A different effect of the two phenolic groups of olivil on the antioxidant activity was also observed...
  53. ncbi request reprint Radical and superoxide scavenging activities of matairesinol and oxidized matairesinol
    Satoshi Yamauchi
    Faculty of Agriculture, Ehime University, Japan
    Biosci Biotechnol Biochem 70:1934-40. 2006
    ..The superoxide scavenging activity of the oxidized matairesinols was also demonstrated for the first time. It is assumed that the pKa value of phenol in the oxidized matairesinols affected this activity...