Kazuya Kondo

Summary

Affiliation: The University of Tokushima
Country: Japan

Publications

  1. ncbi request reprint Mutations of the p53 gene in human lung cancer from chromate-exposed workers
    K Kondo
    Second Department of Surgery, School of Medicine, University of Tokushima, Japan
    Biochem Biophys Res Commun 239:95-100. 1997
  2. ncbi request reprint The reduced expression and aberrant methylation of p16(INK4a) in chromate workers with lung cancer
    Kazuya Kondo
    Department of Oncological and Regenerative Surgery, Institute of Health Biosciences, University of Tokushima Graduate School, 3 Chome, Kuramoto Cho, Tokushima City 770 8503, Japan
    Lung Cancer 53:295-302. 2006
  3. ncbi request reprint Microscopic analysis of chromium accumulation in the bronchi and lung of chromate workers
    Kazuya Kondo
    Department of Oncological and Regenerative Surgery, School of Medicine, University of Tokushima, Tokushima, Japan
    Cancer 98:2420-9. 2003
  4. ncbi request reprint Lymphogenous and hematogenous metastasis of thymic epithelial tumors
    Kazuya Kondo
    Department of Oncological and Regenerative Surgery, School of Medicine, University of Tokushima, Tokushima, Japan
    Ann Thorac Surg 76:1859-64; discussion 1864-5. 2003
  5. ncbi request reprint WHO histologic classification is a prognostic indicator in thymoma
    Kazuya Kondo
    Department of Oncological and Regenerative Surgery, School of Medicine, University of Tokushima, Tokushima, Japan
    Ann Thorac Surg 77:1183-8. 2004
  6. ncbi request reprint Multilocular thymic cyst associated with Sjögren's syndrome
    K Kondo
    Second Department of Surgery, School of Medicine, University of Tokushima, Japan
    Ann Thorac Surg 72:1367-9. 2001
  7. ncbi request reprint Therapy for thymic epithelial tumors: a clinical study of 1,320 patients from Japan
    Kazuya Kondo
    Department of Oncological and Regenerative Surgery, School of Medicine, University of Tokushima, Tokushima, Japan
    Ann Thorac Surg 76:878-84; discussion 884-5. 2003
  8. ncbi request reprint Activation of matrix metalloproteinase-2 is correlated with invasiveness in thymic epithelial tumors
    K Kondo
    Second Department of Surgery, School of Medicine, University of Tokushima, Kuramoto Cho, Tokushima, Japan
    J Surg Oncol 76:169-75. 2001
  9. ncbi request reprint Orthotopically implanted SCID mouse model of human lung cancer suitable for investigating metastatic potential and anticancer drug effects
    Kazuya Kondo
    Department of Oncological and Regenerative Surgery, Institute of Health Biosciences, University of Tokushima Graduate School, 3 Chome, Kuramoto Cho, Tokushima City 770 8503, Japan
    Oncol Rep 12:991-9. 2004
  10. ncbi request reprint Two cases of repeatedly recurrent atypical thymoma
    K Kondo
    Second Department of Surgery, School of Medicine, The University of Tokushima, Japan
    Chest 115:282-5. 1999

Collaborators

Detail Information

Publications76

  1. ncbi request reprint Mutations of the p53 gene in human lung cancer from chromate-exposed workers
    K Kondo
    Second Department of Surgery, School of Medicine, University of Tokushima, Japan
    Biochem Biophys Res Commun 239:95-100. 1997
    ..Half of the mutational sites (3/ 6) had changes of AT base-pairs, and 2 of 4 mutational tumor samples had double missense mutations. Our results suggested that chromate exposure may induce point mutation of the p53 gene...
  2. ncbi request reprint The reduced expression and aberrant methylation of p16(INK4a) in chromate workers with lung cancer
    Kazuya Kondo
    Department of Oncological and Regenerative Surgery, Institute of Health Biosciences, University of Tokushima Graduate School, 3 Chome, Kuramoto Cho, Tokushima City 770 8503, Japan
    Lung Cancer 53:295-302. 2006
    ..Our previous studies revealed a variety of genetic changes in lung cancers from chromate-exposed workers (chromate lung cancer). However, the epigenetic effects of chromium are not understood...
  3. ncbi request reprint Microscopic analysis of chromium accumulation in the bronchi and lung of chromate workers
    Kazuya Kondo
    Department of Oncological and Regenerative Surgery, School of Medicine, University of Tokushima, Tokushima, Japan
    Cancer 98:2420-9. 2003
    ..It is known that chromium is an inhaled carcinogen and an important risk factor in the development of lung carcinoma...
  4. ncbi request reprint Lymphogenous and hematogenous metastasis of thymic epithelial tumors
    Kazuya Kondo
    Department of Oncological and Regenerative Surgery, School of Medicine, University of Tokushima, Tokushima, Japan
    Ann Thorac Surg 76:1859-64; discussion 1864-5. 2003
    ..A TNM classification has been established for various tumors. However, the TNM classification of thymic epithelial tumor has not been established yet...
  5. ncbi request reprint WHO histologic classification is a prognostic indicator in thymoma
    Kazuya Kondo
    Department of Oncological and Regenerative Surgery, School of Medicine, University of Tokushima, Tokushima, Japan
    Ann Thorac Surg 77:1183-8. 2004
    ..The histologic classification of thymoma has remained a subject of controversy for many years. In 1999, the World Health Organization Consensus Committee published a histologic typing system for tumors of the thymus...
  6. ncbi request reprint Multilocular thymic cyst associated with Sjögren's syndrome
    K Kondo
    Second Department of Surgery, School of Medicine, University of Tokushima, Japan
    Ann Thorac Surg 72:1367-9. 2001
    ..She was diagnosed with multilocular thymic cysts associated with Sjögren's syndrome...
  7. ncbi request reprint Therapy for thymic epithelial tumors: a clinical study of 1,320 patients from Japan
    Kazuya Kondo
    Department of Oncological and Regenerative Surgery, School of Medicine, University of Tokushima, Tokushima, Japan
    Ann Thorac Surg 76:878-84; discussion 884-5. 2003
    ..Surgery remains the mainstay of treatment for thymic epithelial tumors, and radiation and chemotherapy also have been applied widely as adjuvant and palliative procedures...
  8. ncbi request reprint Activation of matrix metalloproteinase-2 is correlated with invasiveness in thymic epithelial tumors
    K Kondo
    Second Department of Surgery, School of Medicine, University of Tokushima, Kuramoto Cho, Tokushima, Japan
    J Surg Oncol 76:169-75. 2001
    ..BACKGROUND AND OBJECTS: Matrix degradation, which is a critical event in the process of tumor invasion and metastasis, is considered to be caused by the action of proteolytic enzymes...
  9. ncbi request reprint Orthotopically implanted SCID mouse model of human lung cancer suitable for investigating metastatic potential and anticancer drug effects
    Kazuya Kondo
    Department of Oncological and Regenerative Surgery, Institute of Health Biosciences, University of Tokushima Graduate School, 3 Chome, Kuramoto Cho, Tokushima City 770 8503, Japan
    Oncol Rep 12:991-9. 2004
    ....
  10. ncbi request reprint Two cases of repeatedly recurrent atypical thymoma
    K Kondo
    Second Department of Surgery, School of Medicine, The University of Tokushima, Japan
    Chest 115:282-5. 1999
    ..The patients with atypical thymoma must be followed up carefully due to a possible recurrence. Surgical treatment with chemoradiotherapy can lengthen their survival...
  11. ncbi request reprint Thymoma and myasthenia gravis: a clinical study of 1,089 patients from Japan
    Kazuya Kondo
    Department of Oncological and Regenerative Surgery, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan
    Ann Thorac Surg 79:219-24. 2005
    ....
  12. ncbi request reprint High frequency expressions of CD44 standard and variant forms in non-small cell lung cancers, but not in small cell lung cancers
    K Kondo
    Second Department of Surgery, School of Medicine, University of Tokushima, Tokushima City, Japan
    J Surg Oncol 69:128-36. 1998
    ..Organ specificity has been demonstrated in the mode of CD44 expression among several cancers...
  13. doi request reprint Tumor-node metastasis staging system for thymic epithelial tumors
    Kazuya Kondo
    Department of Oncological Medical Services, Institute of Health Biosciences, The University of Tokushima Graduate School, Japan
    J Thorac Oncol 5:S352-6. 2010
    ..in National Cancer Institute of Italy in 2005 (NCII system)...
  14. ncbi request reprint Invited commentary
    Kazuya Kondo
    Department of Oncological and Regenerative Surgery, University of Tokushima Graduate School, Tokushima, 770 8503, Japan
    Ann Thorac Surg 80:2000-1. 2005
  15. ncbi request reprint Myasthenia gravis appearing after thymectomy for thymoma
    Kazuya Kondo
    Department of Oncological and Regenerative Surgery, Institute of Health Biosciences, University of Tokushima Graduate School, Kuramoto Cho, Tokushima 770 8503, Japan
    Eur J Cardiothorac Surg 28:22-5. 2005
    ..However, the cause of this is not yet known because of the rarity of postoperative MG patients. This study evaluated the clinical characteristics of the 8 postoperative MG patients...
  16. ncbi request reprint Effect of mediastinal lymph nodes sampling in patients with clinical stage I non-small cell lung cancer
    Hiromitsu Takizawa
    Department of Oncological and Regenerative Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    J Med Invest 55:37-43. 2008
    ..In this retrospective study, we evaluated the effect of mediastinal lymph node sampling in patients with clinical stage I NSCLC...
  17. ncbi request reprint Matrix metalloproteinase inhibitor MMI-166 inhibits lymphogenous metastasis in an orthotopically implanted model of lung cancer
    Haruhiko Fujino
    Department of Oncological and Regenerative Surgery, School of Medicine, University of Tokushima, Kuramoto Cho, Japan
    Mol Cancer Ther 4:1409-16. 2005
    ..039). These results showed that MMI-166 could possibly inhibit lymph node metastasis and prolong the life span in lung cancer patients...
  18. doi request reprint Aberrant methylation of tumour-related genes in thymic epithelial tumours
    Yukiko Hirose
    Department of Oncological and Regenerative Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Japan
    Lung Cancer 64:155-9. 2009
    ..Thymoma is an uncommon neoplasm derived from epithelial cells of the thymus. Few studies have addressed the genetic alterations that occur in the tumourigenesis of thymoma...
  19. ncbi request reprint Microscopic analysis of the chromium content in the chromium-induced malignant and premalignant bronchial lesions of the rat
    Yuji Takahashi
    Department of Oncological and Regenerative Surgery, Institute of Health Biosciences, University of Tokushima Graduate School, Kuramoto Cho, Tokushima 770 8503, Japan
    Environ Res 99:267-72. 2005
    ....
  20. ncbi request reprint Microsatellite instability and protein expression of the DNA mismatch repair gene, hMLH1, of lung cancer in chromate-exposed workers
    Yuji Takahashi
    Department of Oncological and Regenerative Surgery, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima City, Japan
    Mol Carcinog 42:150-8. 2005
    ..039). The inactivation of hMLH1 expression strongly correlated with the microsatellite high instability phenotype in chromate lung cancer. The genetic instability of chromate lung cancer is due to the repression of hMLH1 protein...
  21. ncbi request reprint Establishment of patient-like SCID mouse model by orthotopically implanting primary cultured cells from surgically-resected lung cancer tissues
    Haruhiko Fujino
    Department of Oncological and Regenerative Surgery, School of Medicine, University of Tokushima, Tokushima, Japan
    Oncol Rep 10:1709-15. 2003
    ..As the lymphogenous metastatic potential of this model reflects that of the clinical tumor, it is useful for elucidating the mechanism of lymphogenous metastasis and selecting anticancer drugs suitable for an individual patients...
  22. ncbi request reprint Thymidylate synthase and dihydropyrimidine dehydrogenase in non-small cell lung cancer: relationship between mRNA expression and activity
    Takanori Miyoshi
    Department of Oncological and Regenerative Surgery, School of Medicine, University of Tokushima, Kuramoto Cho, Tokushima 770 8503, Japan
    Anticancer Res 25:923-30. 2005
    ..In the present study, we investigated TS and DPD activity in resected tumors and corresponding normal lungs and the relationship between the activity and the mRNA expression of TS and DPD in NSCLC...
  23. pmc 18F-fluorodeoxyglucose positron emission tomography/computed tomography is useful in postoperative follow-up of asymptomatic non-small-cell lung cancer patients
    Hiroaki Toba
    Department of Thoracic and Endocrine Surgery and Oncology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    Interact Cardiovasc Thorac Surg 15:859-64. 2012
    ....
  24. ncbi request reprint Predictive value of thymidylate synthase and dihydropyrimidine dehydrogenase expression in tumor tissue, regarding the efficacy of postoperatively administered UFT (tegafur+uracil) in patients with non-small cell lung cancer
    Takanori Miyoshi
    Department of Oncological and Regenerative Surgery, Institute of Health Bioscience, University of Tokushima Graduate School, Kuramoto Cho, Tokushima, Japan
    Anticancer Res 27:2641-8. 2007
    ..Thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) expression were investigated in resected tumors and the relationship between their expression and clinical factors in NSCLC patients was examined...
  25. doi request reprint Late pulmonary metastases from malignant melanoma of the left planta
    Hiroaki Toba
    Department of Thoracic, Endocrine Surgery, and Oncology, Institute of Health Bioscience, The University of Tokushima, Kuramoto Cho, Tokushima, Japan
    Gen Thorac Cardiovasc Surg 57:558-61. 2009
    ..If it does occur, an operation should be considered under limited indications. We should also recognize that recurrence may occur within a short interval after metastatectomy as well...
  26. ncbi request reprint Lung regeneration: implantation of fetal rat lung fragments into adult rat lung parenchyma
    Koichiro Kenzaki
    Department of Oncological and Regenerative Surgery, University of Tokushima Graduate School, Tokushima, Japan
    J Thorac Cardiovasc Surg 131:1148-53. 2006
    ..We hypothesized that fetal lung tissues, with great potential for growth and differentiation, could be used for lung regeneration...
  27. ncbi request reprint [Clinical analysis of elderly patients with primary lung cancer]
    Koichiro Kenzaki
    Department of Thoracic, Endocrine Surgery and Oncology, Institute of Health Bioscience, The University of Tokushima, Tokushima, Japan
    Kyobu Geka 63:519-23; discussion 524-6. 2010
    ..For elderly patients, it is important to consider quality of life as well as the survival rate...
  28. ncbi request reprint Fluorescence diagnosis of lymph node metastasis of lung cancer in a mouse model
    Hiromitsu Takizawa
    Department of Thoracic, Endocrine Surgery and Oncology, Institute of Health Bioscience, The University of Tokushima Graduate School, Kuramotocho, Tokushima, Japan
    Oncol Rep 22:17-21. 2009
    ..In conclusion, fluorescence diagnosis of lymph node metastasis is possible in a mouse model. The successful result with small lymph node metastasis suggests the possibility of clinical application...
  29. ncbi request reprint Green fluorescent protein expression and visualization of mediastinal lymph node metastasis of human lung cancer cell line using orthotopic implantation
    Hisashi Ishikura
    The Department of Oncological and Regenerative Surgery, School of Medicine, The University of Tokushima, Tokushima City, Japan
    Anticancer Res 24:719-23. 2004
    ..We have reported a patient-like model of lung cancer metastasis based on orthotopic implantation in severe combined immunodeficiency (SCID) mice and demonstrated the lymphogenous spread histologically using human NSCLC cell lines...
  30. ncbi request reprint Increased expression of matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 is correlated with poor prognostic variables in patients with thymic epithelial tumors
    Ken Ichi Sogawa
    Department of Oncological and Regenerative Surgery, School of Medicine, University of Tokushima, Tokushima, Japan
    Cancer 98:1822-9. 2003
    ..The current study investigated whether the expression of MMP and TIMP was correlated with tumor invasiveness and prognosis in patients with thymoma...
  31. ncbi request reprint Diagnosis of the presence of lymph node metastasis and decision of operative indication using fluorodeoxyglucose-positron emission tomography and computed tomography in patients with primary lung cancer
    Hiroaki Toba
    Department of Thoracic and Endocrine Surgery and Oncology, Institute of Health Biosciences, The University of Tokushima Graduate School
    J Med Invest 57:305-13. 2010
    ..We evaluate whether integrated fluorodeoxyglucose-positron emission tomography and computed tomography (FDG-PET/CT) scan can diagnose the presence of lymph node metastasis more accurately than computed tomography (CT) scan alone...
  32. ncbi request reprint Frequent microsatellite instability in lung cancer from chromate-exposed workers
    Toshiyuki Hirose
    Second Department of Surgery, School of Medicine, University of Tokushima, Tokushima, Japan
    Mol Carcinog 33:172-80. 2002
    ..In addition to our previous study of p53 mutations, the present findings suggest that the carcinogenic mechanism of chromate lung cancer may differ from that of non-chromate lung cancer...
  33. doi request reprint Fluoroscopy-assisted thoracoscopic resection after computed tomography-guided bronchoscopic metallic coil marking for small peripheral pulmonary lesions
    Hiroaki Toba
    Department of Thoracic and Endocrine Surgery and Oncology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    Eur J Cardiothorac Surg 44:e126-32. 2013
    ..To re-evaluate the efficacy of fluoroscopy-assisted thoracoscopic resection after computed tomography (CT)-guided bronchoscopic metallic coil marking (FATS-CM), which was our original method for small peripheral pulmonary lesions...
  34. ncbi request reprint [Lung cancer in patient with a common trunk of left pulmonary veins; report of two cases]
    Naoya Kawakita
    Department of Thoracic, Endocrine Surgery and Oncology, The University of Tokushima Graduate School, Tokushima, Japan
    Kyobu Geka 63:915-8. 2010
    ..This variation type is surgically important because of a potential risk of intraoperative bleeding and damage to pulmonary circulation during pulmonary resection...
  35. ncbi request reprint Fluoroscopy-assisted thoracoscopic resection of pulmonary nodules after computed tomography--guided bronchoscopic metallic coil marking
    Takanori Miyoshi
    Department of Oncological and Regenerative Surgery, Institute of Health Biosciences, University of Tokushima Graduate School, Kuramoto Cho, Tokushima, Japan
    J Thorac Cardiovasc Surg 131:704-10. 2006
    ..To localize small and deeply situated pulmonary nodules during thoracoscopy with roentgenographic fluoroscopy, we developed a marking procedure that uses a metallic coil...
  36. doi request reprint Functional evaluation of pallid mice with genetic emphysema
    Mitsuteru Yoshida
    Department of Thoracic, Endocrine Surgery and Oncology, Institute of Health Bioscience, The University of Tokushima Graduate School, Tokushima, Japan
    Lab Invest 89:760-8. 2009
    ..The deterioration in the exercise capacity and pulmonary function preceded the microscopic morphological changes...
  37. doi request reprint Computed tomography lymphography by transbronchial injection of iopamidol to identify sentinel nodes in preoperative patients with non-small cell lung cancer: a pilot study
    Hiromitsu Takizawa
    Department of Thoracic, Endocrine Surgery, and Oncology, University of Tokushima Graduate School, Tokushima, Japan
    J Thorac Cardiovasc Surg 144:94-9. 2012
    ..The objective of the present study was to assess the safety and feasibility of computed tomography lymphography by transbronchial injection of a water-soluble extracellular computed tomography contrast agent...
  38. ncbi request reprint Extramedullary plasmacytoma immunoglobulin D (lambda) in the chest wall and the subglottic region
    Shoji Sakiyama
    Department of Oncological Surgery, Graduate School of Medicine, University of Tokushima, Kuramoto Cho 3, Tokushima 770 8503, Japan
    J Thorac Cardiovasc Surg 129:1168-9. 2005
  39. doi request reprint Triterpenes augment the inhibitory effects of anticancer drugs on growth of human esophageal carcinoma cells in vitro and suppress experimental metastasis in vivo
    Hiromichi Yamai
    Department of Thoracic, Endocrine Surgery and Oncology, Institute of Health Bioscience, The University of Tokushima Graduate School, Tokushima, Japan
    Int J Cancer 125:952-60. 2009
    ..These results suggest that triterpenes, especially JAE, are effective supplements for enhancing the chemotherapeutic effect of 5-fluorouracil on esophageal cancer...
  40. ncbi request reprint Optimal therapy for thymoma
    Kazuya Kondo
    Department of Adult and Gerontological Nursing, School of Health Sciences, The University of Tokushima, Tokushima, Japan
    J Med Invest 55:17-28. 2008
    ..Multimodality therapy involving surgery, chemotherapy and radiotherapy appears to increase the rate of complete resection and survival in advanced (stage III and IV) thymomas...
  41. doi request reprint 18F-fluorodeoxyglucose positron emission tomography/computed tomography and the relationship between fluorodeoxyglucose uptake and the expression of hypoxia-inducible factor-1α, glucose transporter-1 and vascular endothelial growth factor in thymic epithe
    Hiroaki Toba
    Department of Thoracic and Endocrine Surgery and Oncology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    Eur J Cardiothorac Surg 44:e105-12. 2013
    ....
  42. doi request reprint Recurrent thymoma with a pleural dissemination invading the intervertebral foramen
    Hiroaki Toba
    Department of Thoracic, Endocrine Surgery and Oncology, Institute of Health Bioscience, The University of Tokushima, Tokushima, Japan
    Eur J Cardiothorac Surg 35:917-9. 2009
    ..She underwent complete resection of the tumor and postoperative radiotherapy. The resected specimen was histologically diagnosed as a pleural dissemination from thymoma. There has been no local recurrence...
  43. doi request reprint Pemphigus with thymoma improved by thymectomy: report of a case
    Mitsuteru Yoshida
    Department of Thoracic, Endocrine Surgery and Oncology, Institute of Health Bioscience, University of Tokushima Graduate School, Kuramoto cho 3 18 15, Tokushima, 770 8503, Japan
    Surg Today 43:806-8. 2013
    ..The patient's skin symptoms improved, and the steroid dose was gradually lowered and finally discontinued 4 years postoperatively. Extended thymectomy may be an effective therapy for treating patients with pemphigus...
  44. ncbi request reprint Epidemiological and clinical features of lung cancer patients from 1999 to 2009 in Tokushima Prefecture of Japan
    Takanori Kanematsu
    Department of Medical Oncology, Institute of Health Biosciences, The University of Tokushima Gradate School, Tokushima, Japan
    J Med Invest 57:326-33. 2010
    ..3 months and 18.0 months, respectively, which were comparable with those of total population. These results indicated the benefit of chemotherapy in elderly patients with advanced lung cancer by proper selection...
  45. ncbi request reprint Photodynamic therapy for submucosal tumor of the central bronchus
    Kazuya Kondo
    Department of Oncological and Regenerative Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Kuramoto Cho, Tokushima, 770 8503, Japan
    J Med Invest 52:208-11. 2005
    ..Our report recommends that PDT should be applied not only to early lung cancer but also submucosal tumor of the central bronchus...
  46. ncbi request reprint [Treatment for rare subtypes of lung carcinoma]
    Kazuya Kondo
    Second Department of Surgery, School of Medicine, University of Tokushima
    Nihon Rinsho 60:550-3. 2002
  47. ncbi request reprint Fatal air embolism during computed tomography-guided pulmonary marking with a hook-type marker
    Shoji Sakiyama
    Department of Oncological and Regenerative Surgery School of Medicine, The University of Tokushima, Tokushima, Japan
    J Thorac Cardiovasc Surg 126:1207-9. 2003
  48. ncbi request reprint Interventional study for improvement of lung cancer screening rate
    Midori Yoshida
    Graduate School of Health Sciences, The University of Tokushima, Tokushima, Japan
    J Med Invest 59:127-35. 2012
    ..8% for the intervention group and 37.7% for the control group. It was shown that distribution by mail of even a single leaflet made by National Cancer Center was effective for motivation of consultation of lung cancer screening...
  49. ncbi request reprint Autofluorescence bronchoscopy, a novel modality for the early detection of bronchial premalignant and malignant lesions
    Masaki Hanibuchi
    Department of Internal Medicine and Molecular Therapeutics, The University of Tokushima Graduate School, Tokushima, Japan
    J Med Invest 54:261-6. 2007
    ..Autofluorescence bronchoscopy is a novel modality for the early detection of bronchial abnormality, especially for bronchial premalignant lesions...
  50. ncbi request reprint Novel bronchofiberscopic catheter spray device allows effective anesthetic spray and sputum suctioning
    Koichiro Kenzaki
    Department of Oncological and Regenerative Surgery, University of Tokushima, 3 18 15, Tokushima City, Tokushima 770 8503, Japan
    Respir Med 98:606-10. 2004
    ....
  51. ncbi request reprint Occupational cancer genetics: infrequent ras oncogenes point mutations in lung cancer samples from chromate workers
    A A Ewis
    Department of Public Health, School of Medicine, Tokushima University, Tokushima City, Japan
    Am J Ind Med 40:92-7. 2001
    ..CONCLUSIONS: Ras oncogenes activated by point mutations do not have a major role in the process of tumorigenesis of chromate-related lung cancer...
  52. ncbi request reprint The relation between the cancer screening rate and the cancer mortality rate in Japan
    Midori Yoshida
    Department of Community Nursing, Major in Nursing, Institute of Health Biosciences, The University of Tokushima Graduate School, Kuramoto Cho, Tokushima, Japan
    J Med Invest 57:251-9. 2010
    ..001). In future, improvement in lifestyle and in the knowledge of cancer should be promoted to enhance the screening rates...
  53. ncbi request reprint Two cases of bronchogenic cyst with severe adhesion to the trachea
    Mitsuteru Yoshida
    Department of Oncological and Regenerative Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    J Med Invest 54:187-90. 2007
    ..The inner side of the residual cystic wall underwent dull curettage to remove the epithelial component. There were no postoperative complications in either case...
  54. ncbi request reprint Progressive increase of CD4(+)/CD45RC(-) lymphocytes after allograft rat lung transplantation: a marker of acute rejection
    Yoshifumi Takehisa
    Second Department of Surgery, School of Medicine, The University of Tokushima, Kuramoto Cho 3, Tokushima 770 8503, Japan
    J Thorac Cardiovasc Surg 124:675-83. 2002
    ..Lymphocyte infiltration and activation play an important role in acute rejection of transplanted organs, and the dynamic change of lymphocyte subpopulations might be a marker to determine graft rejection after lung transplantation...
  55. ncbi request reprint Postprocessing technique with MDCT data improves the accuracy of the detection of lung nodules
    Kazuhide Yoneda
    Department of Radiology, Tokushima University Medical and Dental Hospital, Tokushima, Japan
    Radiat Med 25:511-5. 2007
    ..The aim of this study was to determine whether postprocessing techniques could improve the accuracy of detecting lung nodules...
  56. ncbi request reprint [Therapy for multiple primary lung cancers]
    Kazuya Kondo
    Second Department of Surgery, School of Medicine, University of Tokushima, Tokushima, Japan
    Kyobu Geka 55:4-9. 2002
    ..002). Therefore it is very important to perform close follow-up surveillance for early detection of cancer...
  57. pmc The balance of VEGF-C and VEGFR-3 mRNA is a predictor of lymph node metastasis in non-small cell lung cancer
    H Takizawa
    Department of Oncological and Regenerative Surgery, University of Tokushima School of Medicine 3 18 15 Kuramotocho, Tokushima 770 8503, Japan
    Br J Cancer 95:75-9. 2006
    ..This suggests that VEGF-C promotes lymph node metastasis while being influenced by the strength of the VEGF-C autocrine loop, and the VEGF-C/VEGFR-3 ratio can be a useful predictor of lymph node metastasis in NSCLC...
  58. ncbi request reprint [Clinical analysis of operative and hospital deaths in primary lung cancer]
    K Kenzaki
    Department of Oncological and Regenerative Surgery, The University of Tokushima Graduate School, Tokushima, Japan
    Kyobu Geka 59:347-52; discussion 352-4. 2006
    ..Furthermore, we must carefully review the preoperative evaluation and combined treatment, because there were many cancer deaths among cases showing early recurrence and metastasis...
  59. ncbi request reprint [Thymic carcinoma]
    K Kondo
    Second Department of Surgery, School of Medicine, University of Tokushima, Tokushina, Japan
    Kyobu Geka 55:701-8. 2002
    ..In this paper thymic carcinoma is reviewed mainly based on recently literatures and results obtained from a questionnaire on thymic epithelial tumors in Japan...
  60. ncbi request reprint Suppression of mediastinal metastasis by uracil-tegafur or cis-diamminedichloroplatinum(II) using a lymphogenous metastatic model in a human lung cancer cell line
    H Ishikura
    Second Department of Surgery, School of Medicine, University of Tokushima, 3-18-15 Kuramoto-cho, Tokushima City, Tokushima 770-8503, Japan
    Clin Cancer Res 7:4202-8. 2001
    ..This model should make an important contribution to our understanding of the mechanism and selection of drugs for antilymphatic metastasis in lung cancer...
  61. ncbi request reprint DNA adducts detected in human gastric mucosa
    Mohammed Abdul-Momen
    Second Department of Surgery, School of Medicine, University of Tokushima, 3 18 15, Kuramoto Cho, Tokushima 770 8503, Japan
    Cancer Detect Prev 27:209-15. 2003
    ..G2 was the same DNA adduct as Si2 in the small intestine and C1 in the colon, and G3 was the same as Si1 in the small intestine. Thus, it was demonstrated that the mucosa of the stomach was exposed to DNA-reactive substances...
  62. pmc Betulinic acid augments the inhibitory effects of vincristine on growth and lung metastasis of B16F10 melanoma cells in mice
    N Sawada
    Department of Oncological and Regenerative Surgery, School of Medicine, The University of Tokushima, Tokushima 770 8503, Japan
    Br J Cancer 90:1672-8. 2004
    ..These results suggest that BA is an effective supplement for enhancing the chemotherapeutic effect on malignant melanoma...
  63. pmc High frequency of p53 protein expression in thymic carcinoma but not in thymoma
    N Hino
    Second Department of Surgery, School of Medicine, The University of Tokushima, Japan
    Br J Cancer 76:1361-6. 1997
    ..Another was a silent mutation. p53 protein accumulation is highly frequent in thymic carcinomas but not in thymomas, and gene mutation is uncommon in thymic carcinomas...
  64. doi request reprint Undiminished regulatory T cells in the thymus of patients with myasthenia gravis
    N Matsui
    Department of Neurology, Institute of Health Bioscience, Graduate School of Medical Sciences, The University of Tokushima, 3 18 15 Kuramoto, Tokushima 770 8503, Japan
    Neurology 74:816-20. 2010
    ..To address this point, we examined the number and distribution of Treg cells in a large number of patients with MG...
  65. ncbi request reprint GDNF-induced neurite formation was stimulated by protein kinase inhibitors and suppressed by Ras inhibitors
    T Hiwasa
    Department of Biochemistry, School of Medicine, Chiba University, Japan
    Neurosci Lett 238:115-8. 1997
    ..These results suggest that a tyrosine protein kinase has a suppressive role in the neurite formation induced by GDNF and that Ras is necessary for the signaling initiated by GDNF...
  66. ncbi request reprint [Approach by clamshell incision for bilateral pulmonary metastasis]
    Mitsuteru Yoshida
    Department of Oncological and Regenerative Surgery, Institute of Health Bioscience, The University of Tokushima Graduate School, Tokushima, Japan
    Kyobu Geka 61:206-9. 2008
    ..In cases that are expected multiple procedures, bilateral thoracotomy by clamshell incision is recommended because it allows another route for thoracotomy at reoperation...
  67. ncbi request reprint Potent growth-suppressive activity of a serine protease inhibitor, ONO-3403, toward malignant human neuroblastoma cell lines
    T Hiwasa
    Department of Biochemistry, School of Medicine, Chiba University, Japan
    Cancer Lett 126:221-5. 1998
    ..Since N-myc amplification in neuroblastomas is well correlated with a poor prognosis, ONO-3403 could be an effective anticancer drug for malignant neuroblastomas...
  68. ncbi request reprint Down-regulation of protein kinase C alpha and gamma and enhanced TPA-induced neurite formation in DAN-transfected neuroblastoma cells
    T Hiwasa
    Department of Biochemistry, School of Medicine, Chiba University, Japan
    FEBS Lett 440:25-8. 1998
    ..This suggests that DAN-transfected cells contain activated calpain which may cause down-regulation of PKC and hence induce the altered TPA response...
  69. ncbi request reprint [Clinical experience with 16 cases of mediastinal lymphoma]
    Hiroaki Toba
    Department of Oncological and Regenerative Surgery, The University of Tokushima Graduate School, Tokushima, Japan
    Kyobu Geka 61:97-101. 2008
    ..When histological diagnosis can not be made by needle biopsy, open biopsy should be done...
  70. ncbi request reprint Establishment and characterization of a human B cell line from the lung tissue of a patient with scleroderma; extraordinary high level of IL-6 secretion by stimulated fibroblasts
    K Kondo
    Second Department of Surgery, Aichi Medical University, Nagakute, Aichi, 480-1195, Japan
    Cytokine 13:220-6. 2001
    ..Thus, abnormally augmented B cell proliferation and the inflammatory response stimulated by these cells may cause the fibrotic changes in patients with progressive systemic sclerosis...
  71. doi request reprint Increasing incidence of elderly onset patients with myasthenia gravis in a local area of Japan
    N Matsui
    Department of Neurology, Institute of Health Bioscience, Tokushima University Graduate School of Medicine, Tokushima, Japan
    J Neurol Neurosurg Psychiatry 80:1168-71. 2009
    ..As the number of elderly patients with myasthenia gravis (MG) has recently increased in Europe and the USA, a retrospective survey of Japanese MG patients was conducted in a single neurological centre over several decades...
  72. ncbi request reprint [Clinical analysis of tracheoplasty and bronchoplasty in primary lung cancer]
    K Kenzaki
    Department of Thoracic, Endocrine Surgery and Oncology, The University of Tokushima Graduate School, Tokushima, Japan
    Kyobu Geka 61:951-6. 2008
    ..There were 2 operative hospital deaths among 3 angio-bronchoplasties without coverage. Recently, we have routinely covered the anastomosis at the reconstruction site and have not experienced any major complications...
  73. ncbi request reprint [Surgically treated pleomorphic carcinoma of the lung]
    H Toba
    Department of Thoracic and Endocrine Surgery and Oncology, The University of Tokushima Graduate School, Tokushima, Japan
    Kyobu Geka 62:202-6. 2009
    ..Since one patient (case 3) had nonmetastatic lymph nodes with vessel invasions, careful observation is considered to be necessary...
  74. ncbi request reprint Surfactant protein B gene variations and susceptibility to lung cancer in chromate workers
    Ashraf A Ewis
    Single Molecule Bioanalysis Laboratory, National Institute of Advanced Industrial Science and Technology AIST, Takamatsu, Japan
    Am J Ind Med 49:367-73. 2006
    ....
  75. ncbi request reprint The organ transplant law of Japan--the past, the present, and the future
    Kazuya Kondo
    Kanagawa University Law School, Japan
    J Int Bioethique 16:91-102, 195. 2005
    ..It has stagnated, rather than promoted, the organ transplant in Japan for the last 8 years. We believe that the Law should be reformed by making an about-face from the current "opt-in" to the "opt-out" principle...
  76. ncbi request reprint Primary pulmonary malignant peripheral nerve sheath tumor: a case report
    Takashi Tashiro
    Pathology Division, Hyogo Prefectural Kakogawa Hospital, Hyogo, Japan
    Acta Cytol 51:820-4. 2007
    ..Although the histologic features of malignant peripheral nerve sheath tumor (MPNST) have been described, the cytologic features of primary pulmonary MPNST have not been reported in the literature...