Kiyoto Kasai

Summary

Affiliation: The University of Tokyo
Country: Japan

Publications

  1. doi request reprint Toward an interdisciplinary science of adolescence: insights from schizophrenia research
    Kiyoto Kasai
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Neurosci Res 75:89-93. 2013
  2. doi request reprint Mitigation of sociocommunicational deficits of autism through oxytocin-induced recovery of medial prefrontal activity: a randomized trial
    Takamitsu Watanabe
    Department of Neuropsychiatry, School of Medicine, University of Tokyo, Tokyo, Japan2Department of Physiology, School of Medicine, University of Tokyo, Tokyo, Japan
    JAMA Psychiatry 71:166-75. 2014
  3. doi request reprint A multimodal approach to investigate biomarkers for psychosis in a clinical setting: the integrative neuroimaging studies in schizophrenia targeting for early intervention and prevention (IN-STEP) project
    Shinsuke Koike
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo 113 8655, Japan
    Schizophr Res 143:116-24. 2013
  4. doi request reprint Comprehensive DNA methylation analysis of peripheral blood cells derived from patients with first-episode schizophrenia
    Masaki Nishioka
    Department of Molecular Psychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    J Hum Genet 58:91-7. 2013
  5. doi request reprint Association of decreased prefrontal hemodynamic response during a verbal fluency task with EGR3 gene polymorphism in patients with schizophrenia and in healthy individuals
    Yukika Nishimura
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo 113 8655, Japan Department of Youth Mental Health, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo 113 8655, Japan Electronic address
    Neuroimage 85:527-34. 2014
  6. doi request reprint Reduced but broader prefrontal activity in patients with schizophrenia during n-back working memory tasks: a multi-channel near-infrared spectroscopy study
    Shinsuke Koike
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo 113 8655, Japan
    J Psychiatr Res 47:1240-6. 2013
  7. doi request reprint DNA methylation of the BDNF gene and its relevance to psychiatric disorders
    Tempei Ikegame
    Department of Molecular Psychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    J Hum Genet 58:434-8. 2013
  8. doi request reprint Potential biomarker of subjective quality of life: prefrontal activation measurement by near-infrared spectroscopy
    Yoshihiro Satomura
    a Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo Study Site, Bunkyo ku, Tokyo, Japan
    Soc Neurosci 9:63-73. 2014
  9. pmc Altered metabolites in the plasma of autism spectrum disorder: a capillary electrophoresis time-of-flight mass spectroscopy study
    Hitoshi Kuwabara
    Department of Child Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    PLoS ONE 8:e73814. 2013
  10. doi request reprint Genetic influences on prefrontal activation during a verbal fluency task in adults: a twin study based on multichannel near-infrared spectroscopy
    Eisuke Sakakibara
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan 2 Department of Psychiatry, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan Electronic address
    Neuroimage 85:508-17. 2014

Collaborators

Detail Information

Publications34

  1. doi request reprint Toward an interdisciplinary science of adolescence: insights from schizophrenia research
    Kiyoto Kasai
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Neurosci Res 75:89-93. 2013
    ....
  2. doi request reprint Mitigation of sociocommunicational deficits of autism through oxytocin-induced recovery of medial prefrontal activity: a randomized trial
    Takamitsu Watanabe
    Department of Neuropsychiatry, School of Medicine, University of Tokyo, Tokyo, Japan2Department of Physiology, School of Medicine, University of Tokyo, Tokyo, Japan
    JAMA Psychiatry 71:166-75. 2014
    ..Despite growing prospects for oxytocin as a therapeutic agent for ASD, no direct neurobiological evidence exists for oxytocin's beneficial effects on this core symptom of ASD. This is slowing clinical application of the neuropeptide...
  3. doi request reprint A multimodal approach to investigate biomarkers for psychosis in a clinical setting: the integrative neuroimaging studies in schizophrenia targeting for early intervention and prevention (IN-STEP) project
    Shinsuke Koike
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo 113 8655, Japan
    Schizophr Res 143:116-24. 2013
    ..0%, and 35.3% (at 6, 12, and 24months, respectively). Through this research project, we expect to clarify the pathophysiological features around the onset of psychosis and improve the prognosis of psychosis through clinical application...
  4. doi request reprint Comprehensive DNA methylation analysis of peripheral blood cells derived from patients with first-episode schizophrenia
    Masaki Nishioka
    Department of Molecular Psychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    J Hum Genet 58:91-7. 2013
    ..Our results indicate the site-specific epigenetic alterations in patients with FESZ...
  5. doi request reprint Association of decreased prefrontal hemodynamic response during a verbal fluency task with EGR3 gene polymorphism in patients with schizophrenia and in healthy individuals
    Yukika Nishimura
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo 113 8655, Japan Department of Youth Mental Health, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo 113 8655, Japan Electronic address
    Neuroimage 85:527-34. 2014
    ..Genetic variation in EGR3 may affect prefrontal function through neurodevelopment. This study illustrates the usefulness of NIRS in imaging genetics investigations on psychiatric disorders. ..
  6. doi request reprint Reduced but broader prefrontal activity in patients with schizophrenia during n-back working memory tasks: a multi-channel near-infrared spectroscopy study
    Shinsuke Koike
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo 113 8655, Japan
    J Psychiatr Res 47:1240-6. 2013
    ....
  7. doi request reprint DNA methylation of the BDNF gene and its relevance to psychiatric disorders
    Tempei Ikegame
    Department of Molecular Psychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    J Hum Genet 58:434-8. 2013
    ..Here we review DNA methylation characteristics of BDNF promoters of cellular, animal and clinical samples and discuss future perspectives. ..
  8. doi request reprint Potential biomarker of subjective quality of life: prefrontal activation measurement by near-infrared spectroscopy
    Yoshihiro Satomura
    a Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo Study Site, Bunkyo ku, Tokyo, Japan
    Soc Neurosci 9:63-73. 2014
    ..These findings suggest that subjective QOL has possible involvement in prefrontal function and that NIRS potentially plays a role as a biological marker of subjective QOL...
  9. pmc Altered metabolites in the plasma of autism spectrum disorder: a capillary electrophoresis time-of-flight mass spectroscopy study
    Hitoshi Kuwabara
    Department of Child Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    PLoS ONE 8:e73814. 2013
    ..001) and low lactic acid (pā€Š=ā€Š0.003) in the combined sample (nā€Š=ā€Š53). The present study identified deviated plasma metabolite levels associated with oxidative stress and mitochondrial dysfunction in individuals with ASD. ..
  10. doi request reprint Genetic influences on prefrontal activation during a verbal fluency task in adults: a twin study based on multichannel near-infrared spectroscopy
    Eisuke Sakakibara
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan 2 Department of Psychiatry, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan Electronic address
    Neuroimage 85:508-17. 2014
    ..This implies that the prefrontal hemodynamic dysfunction observed during an executive function task measured by NIRS may be an efficient endophenotype for large-scale imaging genetic studies in psychiatric disorders. ..
  11. doi request reprint Distinct effects of duration of untreated psychosis on brain cortical activities in different treatment phases of schizophrenia: a multi-channel near-infrared spectroscopy study
    Po Han Chou
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo, 113 8655, Japan Department of Psychiatry, Taichung Veterans General Hospital, Taichung City, 40705, Taiwan
    Prog Neuropsychopharmacol Biol Psychiatry 49:63-9. 2014
    ..In the present study, we used near-infrared spectroscopy (NIRS) to investigate the influence of DUP on brain functions during a verbal fluency test (VFT) in patients with schizophrenia...
  12. pmc Diminished medial prefrontal activity behind autistic social judgments of incongruent information
    Takamitsu Watanabe
    Department of Physiology, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    PLoS ONE 7:e39561. 2012
    ....
  13. doi request reprint Functional abnormalities in the left ventrolateral prefrontal cortex during a semantic fluency task, and their association with thought disorder in patients with schizophrenia
    Kohei Marumo
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo 113 8655, Japan
    Neuroimage 85:518-26. 2014
    ....
  14. ncbi request reprint [Current status of epigenetics of schizophrenia]
    Masaki Nishioka
    Department of Molecular Psychiatry, Graduate School of Medicine, The University of Tokyo
    Nihon Rinsho 71:605-9. 2013
    ..Epigenetic studies applying the recent progress of genomics and neuroscience will contribute to better understanding of schizophrenia pathophysiology and the development of therapeutic strategy...
  15. doi request reprint One-year follow up after admission to an emergency department for drug overdose in Japan
    Shuntaro Ando
    Department of Psychiatry and Behavioral Sciences, Tokyo Metropolitan Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Psychiatry Clin Neurosci 67:441-50. 2013
    ..The aim of the study was to investigate the incidence of and risk factors for repetition of suicidal behavior within a year after admission for drug overdose in Japan...
  16. doi request reprint Increased l1 retrotransposition in the neuronal genome in schizophrenia
    Miki Bundo
    Department of Molecular Psychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo 113 8655, Japan Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Saitama 351 0198, Japan
    Neuron 81:306-13. 2014
    ..These findings suggest that hyperactive retrotransposition of L1 in neurons triggered by environmental and/or genetic risk factors may contribute to the susceptibility and pathophysiology of schizophrenia. ..
  17. doi request reprint Comprehensive DNA methylation analysis of human neuroblastoma cells treated with blonanserin
    Yui Murata
    Department of Molecular Psychiatry, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo 113 8655, Japan Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo 113 8655, Japan
    Neurosci Lett 563:123-8. 2014
    ..The DNA methylation changes induced by the treatment with blonanserin will be useful for understanding its pharmacological actions at the cellular level. ..
  18. doi request reprint Localized gray matter volume reductions in the pars triangularis of the inferior frontal gyrus in individuals at clinical high-risk for psychosis and first episode for schizophrenia
    Norichika Iwashiro
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Schizophr Res 137:124-31. 2012
    ..The right PT might preferentially contribute to the pathogenesis of psychotic symptoms...
  19. doi request reprint Effect of mood stabilizers on DNA methylation in human neuroblastoma cells
    Tatsuro Asai
    Department of Molecular Psychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Int J Neuropsychopharmacol 16:2285-94. 2013
    ..Our results will contribute to a better understanding of the epigenetic changes associated with mood disorders, and they also provide new insight into the mechanisms of action of mood stabilizers...
  20. doi request reprint DNA methylation analysis of BDNF gene promoters in peripheral blood cells of schizophrenia patients
    Tempei Ikegame
    Department of Molecular Psychiatry, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Neurosci Res 77:208-14. 2013
    ..Epigenetic alteration of BDNF in the PBC might reflect the pathophysiology of schizophrenia, and could be a potential biomarker. ..
  21. doi request reprint Auditory mismatch negativity and P3a in response to duration and frequency changes in the early stages of psychosis
    Tatsuya Nagai
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan Electronic address
    Schizophr Res 150:547-54. 2013
    ..To our knowledge, this is the first study that examined both MMN/P3a to duration deviant (dMMN/dP3a) and frequency deviant (fMMN/fP3a) in the early stages of psychosis...
  22. pmc A greater number of somatic pain sites is associated with poor mental health in adolescents: a cross-sectional study
    Shuntaro Ando
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    BMC Psychiatry 13:30. 2013
    ....
  23. doi request reprint Differential spatiotemporal characteristics of the prefrontal hemodynamic response and their association with functional impairment in schizophrenia and major depression
    Masaru Kinou
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Schizophr Res 150:459-67. 2013
    ..These results suggest a differential brain pathophysiology between SZ and MDD. Future large-scale studies are needed to determine the practical applicability of these findings for clinical diagnosis and evaluation. ..
  24. doi request reprint Volume reductions in frontopolar and left perisylvian cortices in methamphetamine induced psychosis
    Yuta Aoki
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Schizophr Res 147:355-61. 2013
    ....
  25. pmc Aberrant interference of auditory negative words on attention in patients with schizophrenia
    Norichika Iwashiro
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    PLoS ONE 8:e83201. 2013
    ..The present findings suggest that aberrant interaction between semantic processing of negative emotional content and auditory attention plays a role in production of positive symptoms in schizophrenia. (224 words). ..
  26. doi request reprint Neuroimaging-aided differential diagnosis of the depressive state
    Ryu Takizawa
    Department of Neuropsychiatry, The University of Tokyo Graduate School of Medicine, Tokyo 113 8655, Japan
    Neuroimage 85:498-507. 2014
    ..Potential confounding effects of clinical (e.g., age, sex) and systemic (e.g., autonomic nervous system indices) variables on brain signals will need to be clarified to improve classification accuracy...
  27. doi request reprint Neuronal cell-type specific DNA methylation patterns of the Cacna1c gene
    Masaki Nishioka
    Department of Molecular Psychiatry, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Japan
    Int J Dev Neurosci 31:89-95. 2013
    ....
  28. doi request reprint Psychosocial factors associated with suicidal ideation in clinical patients with depression
    Shuntaro Ando
    Department of Psychiatry and Behavioral Sciences, Tokyo Metropolitan Institute of Medical Science, 2 1 6 Kamikitazawa, Setagaya Ku, Tokyo 156 8506, Japan Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan Electronic address
    J Affect Disord 151:561-5. 2013
    ....
  29. ncbi request reprint [Biological study in schizophrenia]
    Kiyoto Kasai
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Brain Nerve 64:109-18. 2012
    ..Additionally, we present the preliminary findings of the clinical research in our outpatient unit, specialized for early intervention, at the University of Tokyo Hospital...
  30. ncbi request reprint [Integrative neuroimaging for schizophrenia targeting early intervention and prevention (IN-STEP)]
    Kiyoto Kasai
    Graduate School of Medicine, The University of Tokyo
    Rinsho Shinkeigaku 50:822-4. 2010
    ....
  31. doi request reprint Phonological fluency is uniquely impaired in Japanese-speaking schizophrenia patients: confirmation study
    Motomu Suga
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Psychiatry Clin Neurosci 65:672-5. 2011
    ....
  32. pmc A systematic evaluation of whole genome amplification of bisulfite-modified DNA
    Miki Bundo
    Department of Molecular Psychiatry, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Clin Epigenetics 4:22. 2012
    ..abstract:..
  33. ncbi request reprint [Dear young psychiatrists: proposal of a new way of working (NWW) for Japanese psychiatrists through integration of academia and the community]
    Kiyoto Kasai
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo
    Seishin Shinkeigaku Zasshi 115:331-6. 2013
    ..To do so, they need to achieve a deeper understanding of developmental processes of establishing self and values, and the significance of living in the community and employment for human beings...
  34. doi request reprint Cortical thickness, gray matter volume, and white matter anisotropy and diffusivity in schizophrenia
    Mizuho Murakami
    Department of Radiology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Neuroradiology 53:859-66. 2011
    ..The study was conducted to evaluate simultaneously gray matter changes and white matter changes in patients with schizophrenia...