Kiyoto Kasai

Summary

Affiliation: The University of Tokyo
Country: Japan

Publications

  1. doi request reprint The future of real-world neuroscience: imaging techniques to assess active brains in social environments
    Kiyoto Kasai
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan Electronic address
    Neurosci Res 90:65-71. 2015
  2. doi request reprint Toward an interdisciplinary science of adolescence: insights from schizophrenia research
    Kiyoto Kasai
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Neurosci Res 75:89-93. 2013
  3. doi request reprint Structural disruption of the dorsal cingulum bundle is associated with impaired Stroop performance in patients with schizophrenia
    Kunio Takei
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Schizophr Res 114:119-27. 2009
  4. ncbi request reprint Association between lower P300 amplitude and smaller anterior cingulate cortex volume in patients with posttraumatic stress disorder: a study of victims of Tokyo subway sarin attack
    Tsuyoshi Araki
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Tokyo 113 8655, Japan
    Neuroimage 25:43-50. 2005
  5. doi request reprint Association of the neuronal cell adhesion molecule (NRCAM) gene variants with autism
    Tetsuya Marui
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Int J Neuropsychopharmacol 12:1-10. 2009
  6. doi request reprint Association of decreased prefrontal hemodynamic response during a verbal fluency task with EGR3 gene polymorphism in patients with schizophrenia and in healthy individuals
    Yukika Nishimura
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo 113 8655, Japan Department of Youth Mental Health, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo 113 8655, Japan Electronic address
    Neuroimage 85:527-34. 2014
  7. doi request reprint Association between sigma-1 receptor gene polymorphism and prefrontal hemodynamic response induced by cognitive activation in schizophrenia
    Ryu Takizawa
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 33:491-8. 2009
  8. ncbi request reprint Decreased prefrontal activation during letter fluency task in adults with pervasive developmental disorders: a near-infrared spectroscopy study
    Hitoshi Kuwabara
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Behav Brain Res 172:272-7. 2006
  9. ncbi request reprint Reduced frontopolar activation during verbal fluency task in schizophrenia: a multi-channel near-infrared spectroscopy study
    Ryu Takizawa
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Schizophr Res 99:250-62. 2008
  10. doi request reprint Association between the oxytocin receptor gene and amygdalar volume in healthy adults
    Hideyuki Inoue
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Biol Psychiatry 68:1066-72. 2010

Detail Information

Publications85

  1. doi request reprint The future of real-world neuroscience: imaging techniques to assess active brains in social environments
    Kiyoto Kasai
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan Electronic address
    Neurosci Res 90:65-71. 2015
    ..Uncovering the neurobiological mechanisms of the active brain in the presence of others by using real-world neuroimaging will be an important step toward fully understanding the human brain and its mental functions. ..
  2. doi request reprint Toward an interdisciplinary science of adolescence: insights from schizophrenia research
    Kiyoto Kasai
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Neurosci Res 75:89-93. 2013
    ....
  3. doi request reprint Structural disruption of the dorsal cingulum bundle is associated with impaired Stroop performance in patients with schizophrenia
    Kunio Takei
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Schizophr Res 114:119-27. 2009
    ....
  4. ncbi request reprint Association between lower P300 amplitude and smaller anterior cingulate cortex volume in patients with posttraumatic stress disorder: a study of victims of Tokyo subway sarin attack
    Tsuyoshi Araki
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Tokyo 113 8655, Japan
    Neuroimage 25:43-50. 2005
    ..These results provide the first evidence that electrophysiological deficits of controlled attention observed in patients with PTSD may be linked to underlying brain morphological abnormalities...
  5. doi request reprint Association of the neuronal cell adhesion molecule (NRCAM) gene variants with autism
    Tetsuya Marui
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Int J Neuropsychopharmacol 12:1-10. 2009
    ..Considering the important role of the NRCAM gene in brain development, our results therefore indicated that the NRCAM gene is one of the strong candidate genes for autism...
  6. doi request reprint Association of decreased prefrontal hemodynamic response during a verbal fluency task with EGR3 gene polymorphism in patients with schizophrenia and in healthy individuals
    Yukika Nishimura
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo 113 8655, Japan Department of Youth Mental Health, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo 113 8655, Japan Electronic address
    Neuroimage 85:527-34. 2014
    ..Genetic variation in EGR3 may affect prefrontal function through neurodevelopment. This study illustrates the usefulness of NIRS in imaging genetics investigations on psychiatric disorders. ..
  7. doi request reprint Association between sigma-1 receptor gene polymorphism and prefrontal hemodynamic response induced by cognitive activation in schizophrenia
    Ryu Takizawa
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 33:491-8. 2009
    ..Our findings also suggest that the prefrontal hemodynamic response assessed by noninvasive and less demanding NIRS is a useful intermediate phenotype for translational research in schizophrenia...
  8. ncbi request reprint Decreased prefrontal activation during letter fluency task in adults with pervasive developmental disorders: a near-infrared spectroscopy study
    Hitoshi Kuwabara
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Behav Brain Res 172:272-7. 2006
    ..The present results may be also potentially useful for applying NIRS to clinical settings of child psychiatry...
  9. ncbi request reprint Reduced frontopolar activation during verbal fluency task in schizophrenia: a multi-channel near-infrared spectroscopy study
    Ryu Takizawa
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Schizophr Res 99:250-62. 2008
    ....
  10. doi request reprint Association between the oxytocin receptor gene and amygdalar volume in healthy adults
    Hideyuki Inoue
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Biol Psychiatry 68:1066-72. 2010
    ..Genetic studies have revealed a link between the OXTR gene and the susceptibility to autism spectrum disorders (ASD), especially in the social dysfunctional feature of ASD...
  11. doi request reprint Disrupted integrity of the fornix is associated with impaired memory organization in schizophrenia
    Kunio Takei
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Schizophr Res 103:52-61. 2008
    ..We investigated an association between DTI abnormalities of the fornix and impairment of memory organization in schizophrenia...
  12. doi request reprint Genetic influences on prefrontal activation during a verbal fluency task in adults: a twin study based on multichannel near-infrared spectroscopy
    Eisuke Sakakibara
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan 2 Department of Psychiatry, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan Electronic address
    Neuroimage 85:508-17. 2014
    ..This implies that the prefrontal hemodynamic dysfunction observed during an executive function task measured by NIRS may be an efficient endophenotype for large-scale imaging genetic studies in psychiatric disorders. ..
  13. doi request reprint Effect of tryptophan hydroxylase-2 gene variants on amygdalar and hippocampal volumes
    Hideyuki Inoue
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Brain Res 1331:51-7. 2010
    ..These results suggest that amygdalar and hippocampal volumes assessed using MRI may be a useful intermediate phenotype that will uncover the biological pathway linking 5-HT synthesis and emotional behaviors and affective disorders...
  14. doi request reprint Potential biomarker of subjective quality of life: prefrontal activation measurement by near-infrared spectroscopy
    Yoshihiro Satomura
    a Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo Study Site, Bunkyo ku, Tokyo, Japan
    Soc Neurosci 9:63-73. 2014
    ..These findings suggest that subjective QOL has possible involvement in prefrontal function and that NIRS potentially plays a role as a biological marker of subjective QOL...
  15. ncbi request reprint Localized volume reduction in prefrontal, temporolimbic, and paralimbic regions in schizophrenia: an MRI parcellation study
    Hidenori Yamasue
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo, Tokyo 113 8655, Japan
    Psychiatry Res 131:195-207. 2004
    ..These findings indicate the importance of ACG abnormalities in the pathophysiology of schizophrenia...
  16. doi request reprint Cortical thickness, gray matter volume, and white matter anisotropy and diffusivity in schizophrenia
    Mizuho Murakami
    Department of Radiology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Neuroradiology 53:859-66. 2011
    ..The study was conducted to evaluate simultaneously gray matter changes and white matter changes in patients with schizophrenia...
  17. ncbi request reprint Increased positive thought disorder with illness duration in patients with schizophrenia
    Keiko Maeda
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Psychiatry Clin Neurosci 61:687-90. 2007
    ..TDI scores were not associated with verbal memory or executive functioning. These results indicate an ongoing worsening of positive thought disorder through the course of illness in schizophrenia...
  18. doi request reprint Neuroimaging-aided differential diagnosis of the depressive state
    Ryu Takizawa
    Department of Neuropsychiatry, The University of Tokyo Graduate School of Medicine, Tokyo 113 8655, Japan
    Neuroimage 85:498-507. 2014
    ..Potential confounding effects of clinical (e.g., age, sex) and systemic (e.g., autonomic nervous system indices) variables on brain signals will need to be clarified to improve classification accuracy...
  19. ncbi request reprint Phonetic mismatch negativity predicts social skills acquisition in schizophrenia
    Yuki Kawakubo
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Psychiatry Res 152:261-5. 2007
    ..Although preliminary, these results suggest that phonetic MMN could be an index of social skills acquisition in patients with schizophrenia...
  20. doi request reprint Sex dimorphism in gray/white matter volume and diffusion tensor during normal aging
    Osamu Abe
    Department of Radiology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    NMR Biomed 23:446-58. 2010
    ..Our results provide strong evidence of sex dimorphism in global and focal diffusion characteristics during normal aging...
  21. doi request reprint Volume reduction and altered sulco-gyral pattern of the orbitofrontal cortex in first-episode schizophrenia
    Yoichiro Takayanagi
    Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, 2630 Sugitani, Toyama 930 0194, Japan
    Schizophr Res 121:55-65. 2010
    ..In addition, it remains elusive whether the OFC morphology in first-episode patients is related to their clinical features...
  22. ncbi request reprint Impaired cortical network for preattentive detection of change in speech sounds in schizophrenia: a high-resolution event-related potential study
    Kiyoto Kasai
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Japan
    Am J Psychiatry 159:546-53. 2002
    ..The goal in this study was to obtain an electrophysiological index of preattentive detection of change in speech sounds by schizophrenic patients...
  23. ncbi request reprint Multiple-time replicability of near-infrared spectroscopy recording during prefrontal activation task in healthy men
    Toshiaki Kono
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Neurosci Res 57:504-12. 2007
    ..Further studies using different conditions or assessing sensitivity to longitudinal changes following interventions are necessary...
  24. doi request reprint Functional abnormalities in the left ventrolateral prefrontal cortex during a semantic fluency task, and their association with thought disorder in patients with schizophrenia
    Kohei Marumo
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo 113 8655, Japan
    Neuroimage 85:518-26. 2014
    ....
  25. doi request reprint Voxel-based analyses of gray/white matter volume and diffusion tensor data in major depression
    Osamu Abe
    Department of Radiology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Psychiatry Res 181:64-70. 2010
    ..These results suggest that the frontolimbic neural circuit might play an important role in the neuropathology of patients with major depressive disorder...
  26. doi request reprint The influence of gender and personality traits on individual difference in auditory mismatch: a magnetoencephalographic (MMNm) study
    Junko Matsubayashi
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Brain Res 1236:159-65. 2008
    ..Our observation may provide useful information to establish MMN/MMNm as a clinical tool for monitoring auditory cortical function on an individual basis...
  27. doi request reprint Volume reductions in frontopolar and left perisylvian cortices in methamphetamine induced psychosis
    Yuta Aoki
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Schizophr Res 147:355-61. 2013
    ....
  28. ncbi request reprint Voxel-based diffusion tensor analysis reveals aberrant anterior cingulum integrity in posttraumatic stress disorder due to terrorism
    Osamu Abe
    Department of Radiology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Psychiatry Res 146:231-42. 2006
    ..The present study demonstrated further evidence of abnormalities of both the ACC, a structure that is pivotally involved in attention, emotional regulation, and fear conditioning, and of subjacent white matter in the pathology of PTSD...
  29. doi request reprint Differential spatiotemporal characteristics of the prefrontal hemodynamic response and their association with functional impairment in schizophrenia and major depression
    Masaru Kinou
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Schizophr Res 150:459-67. 2013
    ..These results suggest a differential brain pathophysiology between SZ and MDD. Future large-scale studies are needed to determine the practical applicability of these findings for clinical diagnosis and evaluation. ..
  30. doi request reprint Different hemodynamic response patterns in the prefrontal cortical sub-regions according to the clinical stages of psychosis
    Shinsuke Koike
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo 113 8655, Japan
    Schizophr Res 132:54-61. 2011
    ..Multichannel near-infrared spectroscopy (NIRS), which can easily and noninvasively measure hemodynamics over the prefrontal cortex, is a candidate instrument for clinical use...
  31. ncbi request reprint No association between the neuronal pentraxin II gene polymorphism and autism
    Tetsuya Marui
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo, Tokyo 113, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 31:940-3. 2007
    ..Thus, the NPTX2 locus is not likely to play a major role in the development of autism. However, further studies with larger sample size and sequencing of NPTX2 gene are needed to exclude a role of NPTX2 gene in autism...
  32. doi request reprint Association between autism and variants in the wingless-type MMTV integration site family member 2 ( WNT2) gene
    Tetsuya Marui
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Int J Neuropsychopharmacol 13:443-9. 2010
    ..Considering the important role of the WNT2 gene in brain development, our results therefore indicate that the WNT2 gene is one of the strong candidate genes for autism...
  33. doi request reprint Reduced gray matter volume of Brodmann's Area 45 is associated with severe psychotic symptoms in patients with schizophrenia
    Motomu Suga
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Eur Arch Psychiatry Clin Neurosci 260:465-73. 2010
    ..The present study further demonstrated that BA 45 might especially contribute to the production of psychotic symptoms in the patients with schizophrenia...
  34. doi request reprint Localized gray matter volume reductions in the pars triangularis of the inferior frontal gyrus in individuals at clinical high-risk for psychosis and first episode for schizophrenia
    Norichika Iwashiro
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Schizophr Res 137:124-31. 2012
    ..The right PT might preferentially contribute to the pathogenesis of psychotic symptoms...
  35. pmc Association between catechol-O-methyltrasferase Val108/158Met genotype and prefrontal hemodynamic response in schizophrenia
    Ryu Takizawa
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    PLoS ONE 4:e5495. 2009
    ..Here, we investigated spatiotemporal characteristics of the association between prefrontal hemodynamic activation and the COMT genotype using a noninvasive neuroimaging technique, near-infrared spectroscopy (NIRS)...
  36. ncbi request reprint Neuromagnetic correlates of impaired automatic categorical perception of speech sounds in schizophrenia
    Kiyoto Kasai
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Schizophr Res 59:159-72. 2003
    ..The language-related dysfunction in schizophrenic patients may be present at the early stage of auditory processing of relatively simple stimuli such as phonemes, and not just at stages involving higher order semantic processes...
  37. doi request reprint Tract-specific analysis of the superior occipitofrontal fasciculus in schizophrenia
    Natsuko Kunimatsu
    Department of Radiology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, 113 8655, Tokyo, Japan
    Psychiatry Res 164:198-205. 2008
    ..726 (x10(-3) mm(2)/s) (S.D. 0.027)]. Our results suggest that the so-called SOFF may be a structural component connecting the prefrontal area to the thalamus and that it is deteriorated in schizophrenia...
  38. ncbi request reprint Phonetic mismatch negativity predicts verbal memory deficits in schizophrenia
    Yuki Kawakubo
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Neuroreport 17:1043-6. 2006
    ..These results suggest that electrophysiological auditory sensory memory dysfunction underlies the basis for neuropsychological auditory verbal memory deficits in schizophrenia...
  39. ncbi request reprint Electrophysiological abnormalities of spatial attention in adults with autism during the gap overlap task
    Yuki Kawakubo
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Tokyo, Japan
    Clin Neurophysiol 118:1464-71. 2007
    ..We evaluated event-related potentials (ERPs) elicited by attentional disengagement in individuals with autism...
  40. ncbi request reprint Human brain structural change related to acute single exposure to sarin
    Hidenori Yamasue
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Ann Neurol 61:37-46. 2007
    ....
  41. pmc Impaired prefrontal hemodynamic maturation in autism and unaffected siblings
    Yuki Kawakubo
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    PLoS ONE 4:e6881. 2009
    ..Moreover, to clarify the genetic influences on developmental changes in the prefrontal dysfunction in ASD, unaffected siblings of the ASD participants were also assessed...
  42. doi request reprint Association between severe dorsolateral prefrontal dysfunction during random number generation and earlier onset in schizophrenia
    Shinsuke Koike
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Clin Neurophysiol 122:1533-40. 2011
    ..Age at onset is a major factor for predicting social outcome in schizophrenia. In clinical settings, we need an objective assessment tool for evaluating prefrontal function and social outcome...
  43. ncbi request reprint The effect of perospirone on auditory P300 in schizophrenia: a preliminary study
    Tsuyoshi Araki
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 30:1083-90. 2006
    ..These results suggest that clinical improvement in response to perospirone in some patients may, at least in part, be mediated through cognitive change indexed by P300 in chronic schizophrenia...
  44. ncbi request reprint No association between the metabotropic glutamate receptor type 3 gene (GRM3) and schizophrenia in a Japanese population
    Mamoru Tochigi
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo, Tokyo, 113 8655 Japan
    Schizophr Res 88:260-4. 2006
    ..Thus, the present study provides no positive evidence of an association between the GRM3 gene and schizophrenia in the Japanese population...
  45. doi request reprint Voxel-based analysis of the diffusion tensor
    Osamu Abe
    Department of Radiology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Neuroradiology 52:699-710. 2010
    ....
  46. ncbi request reprint Delayed automatic detection of change in speech sounds in adults with autism: a magnetoencephalographic study
    Kiyoto Kasai
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, 113 8655 Tokyo, Japan
    Clin Neurophysiol 116:1655-64. 2005
    ..e. automatic change detection of speech and non-speech sounds, using magnetoencephalographic recording of mismatch response elicited by change in vowels and tones...
  47. ncbi request reprint Electrophysiological indices associated with social functioning outcome in schizophrenia: a 5-year follow-up study
    Keiko Maeda
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo 113 8655, Japan
    Neurosci Res 51:215-8. 2005
    ..N2b amplitude, an electrophysiological index of orienting response, may be associated with longitudinal social functioning outcome in schizophrenia...
  48. ncbi request reprint Brain electric activity for active inhibition of auditory irrelevant information
    Tsuyoshi Araki
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Neurosci Lett 374:11-6. 2005
    ..These results suggest that auditory selective attention process involves not only focusing attention on relevant information, but also inhibitory processing of irrelevant information mediated by the frontal cortex...
  49. ncbi request reprint Confirmation of a relationship between reduced auditory P300 amplitude and thought disorder in schizophrenia
    Kenji Kirihara
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyoku, Tokyo 113 8655, Japan
    Schizophr Res 80:197-201. 2005
    ..These results further suggest that electrophysiological abnormalities of information processing may underlie positive thought disorder in schizophrenia...
  50. doi request reprint A multimodal approach to investigate biomarkers for psychosis in a clinical setting: the integrative neuroimaging studies in schizophrenia targeting for early intervention and prevention (IN-STEP) project
    Shinsuke Koike
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo 113 8655, Japan
    Schizophr Res 143:116-24. 2013
    ..0%, and 35.3% (at 6, 12, and 24months, respectively). Through this research project, we expect to clarify the pathophysiological features around the onset of psychosis and improve the prognosis of psychosis through clinical application...
  51. doi request reprint DNA methylation analysis of BDNF gene promoters in peripheral blood cells of schizophrenia patients
    Tempei Ikegame
    Department of Molecular Psychiatry, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Neurosci Res 77:208-14. 2013
    ..Epigenetic alteration of BDNF in the PBC might reflect the pathophysiology of schizophrenia, and could be a potential biomarker. ..
  52. doi request reprint Auditory mismatch negativity and P3a in response to duration and frequency changes in the early stages of psychosis
    Tatsuya Nagai
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan Electronic address
    Schizophr Res 150:547-54. 2013
    ..To our knowledge, this is the first study that examined both MMN/P3a to duration deviant (dMMN/dP3a) and frequency deviant (fMMN/fP3a) in the early stages of psychosis...
  53. ncbi request reprint Aging in the CNS: comparison of gray/white matter volume and diffusion tensor data
    Osamu Abe
    Department of Radiology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Neurobiol Aging 29:102-16. 2008
    ..These results indicate that diffusion properties and brain volume are complementary markers to the effects of aging...
  54. doi request reprint Differentiation between bipolar disorder and schizophrenia revealed by neural oscillation to speech sounds: an MEG study
    Naoya Oribe
    Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, Japan
    Bipolar Disord 12:804-12. 2010
    ..The current study tested the hypothesis that the eNO to speech sounds could be differentiated between BP and SZ patients...
  55. ncbi request reprint Tachykinin 1 (TAC1) gene SNPs and haplotypes with autism: a case-control study
    Tetsuya Marui
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Brain Dev 29:510-3. 2007
    ..Thus, the TAC1 locus is not likely to play a major role in the development of autism...
  56. ncbi request reprint Gender-common and -specific neuroanatomical basis of human anxiety-related personality traits
    Hidenori Yamasue
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Cereb Cortex 18:46-52. 2008
    ..The results may have implications for why susceptibility to stress-related disorders such as anxiety disorders and depression shows gender and/or individual differences...
  57. doi request reprint Mitigation of sociocommunicational deficits of autism through oxytocin-induced recovery of medial prefrontal activity: a randomized trial
    Takamitsu Watanabe
    Department of Neuropsychiatry, School of Medicine, University of Tokyo, Tokyo, Japan2Department of Physiology, School of Medicine, University of Tokyo, Tokyo, Japan
    JAMA Psychiatry 71:166-75. 2014
    ..Despite growing prospects for oxytocin as a therapeutic agent for ASD, no direct neurobiological evidence exists for oxytocin's beneficial effects on this core symptom of ASD. This is slowing clinical application of the neuropeptide...
  58. doi request reprint Association and interaction analyses of NRG1 and ERBB4 genes with schizophrenia in a Japanese population
    Sae Shiota
    Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Tokyo, 113 8655, Japan
    J Hum Genet 53:929-35. 2008
    ..Thus, our results suggest the possibility that interaction between variants in NRG1 and ERBB4 might contribute to susceptibility for schizophrenia in a Japanese population. Further investigation may be necessary to confirm our results...
  59. doi request reprint Gender difference in right lateral prefrontal hemodynamic response while viewing fearful faces: a multi-channel near-infrared spectroscopy study
    Kohei Marumo
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Neurosci Res 63:89-94. 2009
    ..This observation may help to establish NIRS as a clinical tool for monitoring prefrontal function on an individual basis...
  60. ncbi request reprint P300 amplitude over temporal regions in schizophrenia
    Akira Iwanami
    Department of Neuropsychiatry, Faculty of Medicine, University of Tokyo, Japan
    Eur Arch Psychiatry Clin Neurosci 252:1-7. 2002
    ....
  61. ncbi request reprint Perospirone in the treatment of schizophrenia: effect on verbal memory organization
    Tsuyoshi Araki
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 30:204-8. 2006
    ..Negative symptoms and extrapyramidal side effects were also ameliorated after switching to perospirone. The distinct cognitive enhancement profile of perospirone may be attributable to its partial 5-HT1A agonist action...
  62. doi request reprint Sex-linked neuroanatomical basis of human altruistic cooperativeness
    Hidenori Yamasue
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Cereb Cortex 18:2331-40. 2008
    ..The present findings may also have an implication for the pathophysiology of autism; characterized by severe dysfunction in social reciprocity, abnormalities in social-brain, and disproportionately low probability in females...
  63. pmc Network structure underlying resolution of conflicting non-verbal and verbal social information
    Takamitsu Watanabe
    Department of Physiology, The University of Tokyo School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan, Global Center of Excellence COE Program Comprehensive Center of Education and Research for Chemical Biology of the Diseases, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan, Department of Child Neuropsychiatry, Department of Neuropsychiatry, and Department of Radiology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan, Department of Radiology, Nihon University School of Medicine, 30 1 Oyaguchi kami cho, Itabashi ku, Tokyo 173 8610, Japan and Japan Science, and Technology Agency, CREST, 5 Sambancho, Chiyoda ku, Tokyo, 102 0075, Japan
    Soc Cogn Affect Neurosci 9:767-75. 2014
    ..These findings suggest that, in social conflict resolutions, the ant-dmPFC selectively recruits one of the resolution-type-specific networks through its interaction with resolution-type-specific hub regions...
  64. pmc Altered metabolites in the plasma of autism spectrum disorder: a capillary electrophoresis time-of-flight mass spectroscopy study
    Hitoshi Kuwabara
    Department of Child Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    PLoS ONE 8:e73814. 2013
    ..001) and low lactic acid (pā€Š=ā€Š0.003) in the combined sample (nā€Š=ā€Š53). The present study identified deviated plasma metabolite levels associated with oxidative stress and mitochondrial dysfunction in individuals with ASD. ..
  65. doi request reprint Comprehensive DNA methylation analysis of peripheral blood cells derived from patients with first-episode schizophrenia
    Masaki Nishioka
    Department of Molecular Psychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    J Hum Genet 58:91-7. 2013
    ..Our results indicate the site-specific epigenetic alterations in patients with FESZ...
  66. doi request reprint Effect of mood stabilizers on DNA methylation in human neuroblastoma cells
    Tatsuro Asai
    Department of Molecular Psychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Int J Neuropsychopharmacol 16:2285-94. 2013
    ..Our results will contribute to a better understanding of the epigenetic changes associated with mood disorders, and they also provide new insight into the mechanisms of action of mood stabilizers...
  67. doi request reprint Reduced but broader prefrontal activity in patients with schizophrenia during n-back working memory tasks: a multi-channel near-infrared spectroscopy study
    Shinsuke Koike
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo 113 8655, Japan
    J Psychiatr Res 47:1240-6. 2013
    ....
  68. doi request reprint DNA methylation of the BDNF gene and its relevance to psychiatric disorders
    Tempei Ikegame
    Department of Molecular Psychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    J Hum Genet 58:434-8. 2013
    ..Here we review DNA methylation characteristics of BDNF promoters of cellular, animal and clinical samples and discuss future perspectives. ..
  69. doi request reprint Distinct effects of duration of untreated psychosis on brain cortical activities in different treatment phases of schizophrenia: a multi-channel near-infrared spectroscopy study
    Po Han Chou
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo, 113 8655, Japan Department of Psychiatry, Taichung Veterans General Hospital, Taichung City, 40705, Taiwan
    Prog Neuropsychopharmacol Biol Psychiatry 49:63-9. 2014
    ..In the present study, we used near-infrared spectroscopy (NIRS) to investigate the influence of DUP on brain functions during a verbal fluency test (VFT) in patients with schizophrenia...
  70. pmc Diminished medial prefrontal activity behind autistic social judgments of incongruent information
    Takamitsu Watanabe
    Department of Physiology, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    PLoS ONE 7:e39561. 2012
    ....
  71. ncbi request reprint [Current status of epigenetics of schizophrenia]
    Masaki Nishioka
    Department of Molecular Psychiatry, Graduate School of Medicine, The University of Tokyo
    Nihon Rinsho 71:605-9. 2013
    ..Epigenetic studies applying the recent progress of genomics and neuroscience will contribute to better understanding of schizophrenia pathophysiology and the development of therapeutic strategy...
  72. doi request reprint One-year follow up after admission to an emergency department for drug overdose in Japan
    Shuntaro Ando
    Department of Psychiatry and Behavioral Sciences, Tokyo Metropolitan Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Psychiatry Clin Neurosci 67:441-50. 2013
    ..The aim of the study was to investigate the incidence of and risk factors for repetition of suicidal behavior within a year after admission for drug overdose in Japan...
  73. doi request reprint Comprehensive DNA methylation analysis of human neuroblastoma cells treated with blonanserin
    Yui Murata
    Department of Molecular Psychiatry, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo 113 8655, Japan Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo 113 8655, Japan
    Neurosci Lett 563:123-8. 2014
    ..The DNA methylation changes induced by the treatment with blonanserin will be useful for understanding its pharmacological actions at the cellular level...
  74. doi request reprint Increased l1 retrotransposition in the neuronal genome in schizophrenia
    Miki Bundo
    Department of Molecular Psychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo 113 8655, Japan Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Saitama 351 0198, Japan
    Neuron 81:306-13. 2014
    ..These findings suggest that hyperactive retrotransposition of L1 in neurons triggered by environmental and/or genetic risk factors may contribute to the susceptibility and pathophysiology of schizophrenia. ..
  75. pmc A greater number of somatic pain sites is associated with poor mental health in adolescents: a cross-sectional study
    Shuntaro Ando
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    BMC Psychiatry 13:30. 2013
    ....
  76. pmc Aberrant interference of auditory negative words on attention in patients with schizophrenia
    Norichika Iwashiro
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    PLoS ONE 8:e83201. 2013
    ..The present findings suggest that aberrant interaction between semantic processing of negative emotional content and auditory attention plays a role in production of positive symptoms in schizophrenia. (224 words). ..
  77. doi request reprint Psychosocial factors associated with suicidal ideation in clinical patients with depression
    Shuntaro Ando
    Department of Psychiatry and Behavioral Sciences, Tokyo Metropolitan Institute of Medical Science, 2 1 6 Kamikitazawa, Setagaya Ku, Tokyo 156 8506, Japan Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan Electronic address
    J Affect Disord 151:561-5. 2013
    ....
  78. doi request reprint Neuronal cell-type specific DNA methylation patterns of the Cacna1c gene
    Masaki Nishioka
    Department of Molecular Psychiatry, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Japan
    Int J Dev Neurosci 31:89-95. 2013
    ....
  79. ncbi request reprint [Biological study in schizophrenia]
    Kiyoto Kasai
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Brain Nerve 64:109-18. 2012
    ..Additionally, we present the preliminary findings of the clinical research in our outpatient unit, specialized for early intervention, at the University of Tokyo Hospital...
  80. doi request reprint Potentiation of quantitative electroencephalograms following prefrontal repetitive transcranial magnetic stimulation in patients with major depression
    Yoshihiro Noda
    Laboratory of Neuromodulation, Kinko Hospital, Kanagawa Psychiatric Center, Yokohama, Japan Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Neurosci Res 77:70-7. 2013
    ..Consecutive prefrontal rTMS could induce long-lasting EEG potentiations beyond the aftereffects, resulting in improved cognitive and depressive symptoms...
  81. pmc Effects of an Internet-based cognitive behavioral therapy (iCBT) program in Manga format on improving subthreshold depressive symptoms among healthy workers: a randomized controlled trial
    Kotaro Imamura
    Department of Mental Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    PLoS ONE 9:e97167. 2014
    ....
  82. pmc A systematic evaluation of whole genome amplification of bisulfite-modified DNA
    Miki Bundo
    Department of Molecular Psychiatry, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Clin Epigenetics 4:22. 2012
    ..abstract:..
  83. ncbi request reprint [Integrative neuroimaging for schizophrenia targeting early intervention and prevention (IN-STEP)]
    Kiyoto Kasai
    Graduate School of Medicine, The University of Tokyo
    Rinsho Shinkeigaku 50:822-4. 2010
    ....
  84. doi request reprint Phonological fluency is uniquely impaired in Japanese-speaking schizophrenia patients: confirmation study
    Motomu Suga
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Psychiatry Clin Neurosci 65:672-5. 2011
    ....
  85. ncbi request reprint [Dear young psychiatrists: proposal of a new way of working (NWW) for Japanese psychiatrists through integration of academia and the community]
    Kiyoto Kasai
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo
    Seishin Shinkeigaku Zasshi 115:331-6. 2013
    ..To do so, they need to achieve a deeper understanding of developmental processes of establishing self and values, and the significance of living in the community and employment for human beings...