Shoji Kagami

Summary

Affiliation: The University of Tokushima
Country: Japan

Publications

  1. pmc Glomerular angiotensinogen protein is enhanced in pediatric IgA nephropathy
    Masanori Takamatsu
    Department of Pediatrics, The Institute of Health Bioscience, The University of Tokushima Graduate School, Kuramoto cho 3 chome, Tokushima, Japan
    Pediatr Nephrol 23:1257-67. 2008
  2. pmc Involvement of glomerular renin-angiotensin system (RAS) activation in the development and progression of glomerular injury
    Shoji Kagami
    Department of Pediatrics, Institute of Health Biosciences, The University of Tokushima Graduate School, Kuramoto cho 3 chome, Tokushima, 770 8503, Japan
    Clin Exp Nephrol 16:214-20. 2012
  3. ncbi request reprint PDGF-BB enhances alpha1beta1 integrin-mediated activation of the ERK/AP-1 pathway involved in collagen matrix remodeling by rat mesangial cells
    Shoji Kagami
    Department of Pediatrics, School of Medicine, University of Tokushima, Tokushima, Japan
    J Cell Physiol 198:470-8. 2004
  4. ncbi request reprint Up-regulation of integrin-linked kinase activity in rat mesangioproliferative glomerulonephritis
    Shoji Kagami
    Department of Pediatrics, Institute of Health Biosciences, The University of Tokushima, Graduate School, Tokushima 770 8503, Japan
    Life Sci 78:1794-800. 2006
  5. doi request reprint ERK5 activation enhances mesangial cell viability and collagen matrix accumulation in rat progressive glomerulonephritis
    Maki Urushihara
    Department of Pediatrics, Institute of Health Bioscience, University of Tokushima Graduate School, Tokushima, Japan
    Am J Physiol Renal Physiol 298:F167-76. 2010
  6. doi request reprint Big mitogen-activated protein kinase 1 (BMK1)/extracellular signal regulated kinase 5 (ERK5) is involved in platelet-derived growth factor (PDGF)-induced vascular smooth muscle cell migration
    Yuki Izawa
    Department of Pharmacology, The University of Tokushima Graduate School of Medical Sciences, Tokushima, Japan
    Hypertens Res 30:1107-17. 2007
  7. doi request reprint Dietary doses of nitrite restore circulating nitric oxide level and improve renal injury in L-NAME-induced hypertensive rats
    Yasuhisa Kanematsu
    Department of Pharmacology, Institute of Health Biosciences, University of Tokushima Graduate School, 3 18 15 Kuramoto, Tokushima City, Tokushima 770 8503, Japan
    Am J Physiol Renal Physiol 295:F1457-62. 2008
  8. ncbi request reprint Ebselen inhibits p38 mitogen-activated protein kinase-mediated endothelial cell death by hydrogen peroxide
    Nermin Ali
    Department of Pharmacology, The University of Tokushima School of Medicine, 3 18 15 Kuramoto, Tokushima 770 8503, Japan
    Eur J Pharmacol 485:127-35. 2004
  9. doi request reprint Angiotensin II type I receptor blockade suppresses glomerular renin-angiotensin system activation, oxidative stress, and progressive glomerular injury in rat anti-glomerular basement membrane glomerulonephritis
    Yukiko Kinoshita
    Department of Pediatrics, Institute of Health Bioscience, The University of Tokushima Graduate School, Tokushima, Japan
    Transl Res 158:235-48. 2011
  10. ncbi request reprint Src and Cas are essentially but differentially involved in angiotensin II-stimulated migration of vascular smooth muscle cells via extracellular signal-regulated kinase 1/2 and c-Jun NH2-terminal kinase activation
    Moe Kyaw
    Department of Pharmacology, The University of Tokushima School of Medicine, 3 18 15 Kuramoto, Tokushima 770 8503, Japan
    Mol Pharmacol 65:832-41. 2004

Detail Information

Publications79

  1. pmc Glomerular angiotensinogen protein is enhanced in pediatric IgA nephropathy
    Masanori Takamatsu
    Department of Pediatrics, The Institute of Health Bioscience, The University of Tokushima Graduate School, Kuramoto cho 3 chome, Tokushima, Japan
    Pediatr Nephrol 23:1257-67. 2008
    ..Augmentation of GEC-AGT production with ang II stimulation might drive further glomerular injury in a positive-feedback loop...
  2. pmc Involvement of glomerular renin-angiotensin system (RAS) activation in the development and progression of glomerular injury
    Shoji Kagami
    Department of Pediatrics, Institute of Health Biosciences, The University of Tokushima Graduate School, Kuramoto cho 3 chome, Tokushima, 770 8503, Japan
    Clin Exp Nephrol 16:214-20. 2012
    ..The purpose of this article is to review the recent advances in tissue RAS research with a particular focus on the role of the glomerular RAS in the progression of renal disease...
  3. ncbi request reprint PDGF-BB enhances alpha1beta1 integrin-mediated activation of the ERK/AP-1 pathway involved in collagen matrix remodeling by rat mesangial cells
    Shoji Kagami
    Department of Pediatrics, School of Medicine, University of Tokushima, Tokushima, Japan
    J Cell Physiol 198:470-8. 2004
    ....
  4. ncbi request reprint Up-regulation of integrin-linked kinase activity in rat mesangioproliferative glomerulonephritis
    Shoji Kagami
    Department of Pediatrics, Institute of Health Biosciences, The University of Tokushima, Graduate School, Tokushima 770 8503, Japan
    Life Sci 78:1794-800. 2006
    ..Increased activity of ILK in MCs may contribute to the development of chronic mesangial alterations leading to glomerular scarring...
  5. doi request reprint ERK5 activation enhances mesangial cell viability and collagen matrix accumulation in rat progressive glomerulonephritis
    Maki Urushihara
    Department of Pediatrics, Institute of Health Bioscience, University of Tokushima Graduate School, Tokushima, Japan
    Am J Physiol Renal Physiol 298:F167-76. 2010
    ..Taken together, these results suggest that MC ERK5 phosphorylation by ANG II or H(2)O(2) enhances cell viability and ECM accumulation in an experimental model of chronic GN...
  6. doi request reprint Big mitogen-activated protein kinase 1 (BMK1)/extracellular signal regulated kinase 5 (ERK5) is involved in platelet-derived growth factor (PDGF)-induced vascular smooth muscle cell migration
    Yuki Izawa
    Department of Pharmacology, The University of Tokushima Graduate School of Medical Sciences, Tokushima, Japan
    Hypertens Res 30:1107-17. 2007
    ..From these findings, it is suggested that BMK1 activation leads to VSMC migration induced by PDGF via Gab1-SHP-2 interaction, and that BMK1-mediated VSMC migration may play a role in the pathogenesis of vascular remodeling...
  7. doi request reprint Dietary doses of nitrite restore circulating nitric oxide level and improve renal injury in L-NAME-induced hypertensive rats
    Yasuhisa Kanematsu
    Department of Pharmacology, Institute of Health Biosciences, University of Tokushima Graduate School, 3 18 15 Kuramoto, Tokushima City, Tokushima 770 8503, Japan
    Am J Physiol Renal Physiol 295:F1457-62. 2008
    ..We conclude that dietary nitrite-derived NO generation may serve as a backup system when the nitric oxide synthase/L-arginine-dependent NO generation system is compromised...
  8. ncbi request reprint Ebselen inhibits p38 mitogen-activated protein kinase-mediated endothelial cell death by hydrogen peroxide
    Nermin Ali
    Department of Pharmacology, The University of Tokushima School of Medicine, 3 18 15 Kuramoto, Tokushima 770 8503, Japan
    Eur J Pharmacol 485:127-35. 2004
    ..Thus, inhibition of p38 MAP kinase by ebselen may imply its usefulness for prevention and/or treatment of endothelial cell dysfunction, which was suggested to be the first step in the development of atherosclerosis...
  9. doi request reprint Angiotensin II type I receptor blockade suppresses glomerular renin-angiotensin system activation, oxidative stress, and progressive glomerular injury in rat anti-glomerular basement membrane glomerulonephritis
    Yukiko Kinoshita
    Department of Pediatrics, Institute of Health Bioscience, The University of Tokushima Graduate School, Tokushima, Japan
    Transl Res 158:235-48. 2011
    ....
  10. ncbi request reprint Src and Cas are essentially but differentially involved in angiotensin II-stimulated migration of vascular smooth muscle cells via extracellular signal-regulated kinase 1/2 and c-Jun NH2-terminal kinase activation
    Moe Kyaw
    Department of Pharmacology, The University of Tokushima School of Medicine, 3 18 15 Kuramoto, Tokushima 770 8503, Japan
    Mol Pharmacol 65:832-41. 2004
    ..These findings suggest that Src and Cas are essentially but differentially involved in Ang II-stimulated migration of VSMC through the activation of ERK1/2 and JNK...
  11. doi request reprint A proton magnetic resonance spectroscopic study in autism spectrum disorders: amygdala and orbito-frontal cortex
    Kenji Mori
    Department of Child Health and Nursing, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    Brain Dev 35:139-45. 2013
    ..These findings suggest the presence of neuronal dysfunction in the amygdala and OFC in autism. Dysfunction in the amygdala and OFC may contribute to the pathogenesis of autism...
  12. ncbi request reprint Addition of the antioxidant probucol to angiotensin II type I receptor antagonist arrests progressive mesangioproliferative glomerulonephritis in the rat
    Shuji Kondo
    Department of Pediatrics, The Institute of Health Bioscience, The University of Tokushima Graduate School, Kuramoto cho 3 chome, Tokushima 770 8503, Japan
    J Am Soc Nephrol 17:783-94. 2006
    ..The combination of probucol and candesartan may represent a novel route of therapy for patients with progressive GN...
  13. ncbi request reprint BMK1 is activated in glomeruli of diabetic rats and in mesangial cells by high glucose conditions
    Yuki Suzaki
    Department of Pharmacology and Pediatrics, The University of Tokushima School of Medicine, Tokushima, Japan
    Kidney Int 65:1749-60. 2004
    ..However, the role of BMK1 in diabetic nephropathy has not been elucidated yet...
  14. ncbi request reprint Role of integrin-linked kinase in epithelial-mesenchymal transition in crescent formation of experimental glomerulonephritis
    Maki Shimizu
    Department of Pediatrics, The Institute of Health Bioscience, The University of Tokushima Graduate School, Kuramoto cho 3 chome, Tokushima 770 8503, Japan
    Nephrol Dial Transplant 21:2380-90. 2006
    ..Transforming growth factor-beta (TGF-beta) is involved in the induction and progression of EMT in several tissues...
  15. ncbi request reprint Effects of anti-alpha1 integrin subunit antibody on anti-Thy-1 glomerulonephritis
    Shoji Kagami
    Department of Pediatrics, School of Medicine, University of Tokushima, Japan
    Lab Invest 82:1219-27. 2002
    ..Platelet-derived growth factor-BB may be involved in early collagen matrix reorganization leading to pathologic mesangial remodeling in this GN model...
  16. ncbi request reprint Ebselen inhibits tumor necrosis factor-alpha-induced c-Jun N-terminal kinase activation and adhesion molecule expression in endothelial cells
    Masanori Yoshizumi
    Department of Pharmacology, The University of Tokushima School of Medicine, Tokushima 770 8503, Japan
    Exp Cell Res 292:1-10. 2004
    ..Inhibition of JNK by ebselen may imply its usefulness for the prevention of atherosclerosis relevant to EC activation...
  17. pmc Ebselen attenuates oxidative stress-induced apoptosis via the inhibition of the c-Jun N-terminal kinase and activator protein-1 signalling pathway in PC12 cells
    Masanori Yoshizumi
    Department of Pharmacology, The University of Tokushima School of Medicine, 3 18 15 Kuramoto, Tokushima 770 8503, Japan
    Br J Pharmacol 136:1023-32. 2002
    ..Thus, inhibition of JNK by ebselen may imply its usefulness for treatment of ischaemic cerebral diseases relevant to neuronal cell death...
  18. doi request reprint Evaluation of the GABAergic nervous system in autistic brain: (123)I-iomazenil SPECT study
    Tatsuo Mori
    Department of Pediatrics, Institute of Health Bioscience, The University of Tokushima Graduate School, Tokushima, Japan
    Brain Dev 34:648-54. 2012
    ..We compared (123)I-IMZ SPECT abnormalities in patients who showed intellectual disturbance or focal epileptic discharge on EEG to those in patients without such findings...
  19. doi request reprint Glomerular expression of hydrogen peroxide-inducible clone-5 in human and rat progressive mesangial proliferative glomerulonephritis
    Kenichi Suga
    Department of Pediatrics, Institute of Health Bioscience, The University of Tokushima Graduate School, Tokushima, Japan
    Nephron Exp Nephrol 120:e59-68. 2012
    ..To investigate the involvement of Hic-5 in the pathogenesis of glomerulonephritis (GN), we examined the glomerular expression of Hic-5 in human and rat GN as well as the regulation of Hic-5 by TGF-β(1) in vitro...
  20. ncbi request reprint Transforming growth factor-beta1 stimulates collagen matrix remodeling through increased adhesive and contractive potential by human renal fibroblasts
    Shuji Kondo
    Department of Pediatrics, School of Medicine, University of Tokushima, Kuramoto cho 3 chome, Tokushima 770 8503, Japan
    Biochim Biophys Acta 1693:91-100. 2004
    ....
  21. doi request reprint Tracheal compression due to an elongated aortic arch in patients with congenital heart disease: evaluation using multidetector-row CT
    Noriko Watanabe
    Department of Pediatrics, University of Tokushima, Tokushima 770 8503, Japan
    Pediatr Radiol 39:1048-53. 2009
    ..The airway can become obstructed as a result of compression by an elongated aortic arch...
  22. doi request reprint Multidetector-row computed tomography evaluation of bilateral bronchial narrowing associated with increased pulmonary blood flow in children with congenital heart disease
    Noriko Watanabe
    Department of Pediatrics, University of Tokushima, Tokushima, Japan
    Congenit Heart Dis 7:410-6. 2012
    ..Quantitative assessment of bilateral bronchial narrowing in children with congenital heart disease (CHD) with a left-to-right shunt has not yet been reported...
  23. doi request reprint Decreased benzodiazepine receptor and increased GABA level in cortical tubers in tuberous sclerosis complex
    Kenji Mori
    Department of Pediatrics, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima 770 8503, Japan
    Brain Dev 34:478-86. 2012
    ....
  24. doi request reprint A case of dense deposit disease associated with a group A streptococcal infection without the involvement of C3NeF or complement factor H deficiency
    Kenichi Suga
    Department of Pediatrics, The Institute of Health Bioscience, The University of Tokushima Graduate School, Tokushima University, Tokushima City, Tokushima, 770 8503, Japan
    Pediatr Nephrol 25:1547-50. 2010
    ....
  25. doi request reprint Assessment of modified Blalock-Taussig shunt in children with congenital heart disease using multidetector-row computed tomography
    Manal Mohamed Helmy Nabo
    Department of Pediatrics, University of Tokushima, Kuramoto Cho 3, Tokushima 770 8503, Japan
    Heart Vessels 25:529-35. 2010
    ..4%). Stenotic site diameter and degree of stenosis showed a mild correlation (R² = 010 and 0.25, respectively; p < 0.01 for each). This study demonstrates that MDCT is a promising tool for the detection of lesions in B-T shunts...
  26. doi request reprint Assessment of systemic-pulmonary collateral arteries in children with cyanotic congenital heart disease using multidetector-row computed tomography: comparison with conventional angiography
    Yasunobu Hayabuchi
    Department of Pediatrics, University of Tokushima, Kuramoto Cho 3, Tokushima 770 8503, Japan
    Int J Cardiol 138:266-71. 2010
    ....
  27. doi request reprint Ratio of early diastolic tricuspid inflow to tricuspid lateral annulus velocity reflects pulmonary regurgitation severity but not right ventricular diastolic function in children with repaired Tetralogy of Fallot
    Yasunobu Hayabuchi
    Department of Pediatrics, University of Tokushima, Kuramoto Cho 3, Tokushima 770 8305, Japan
    Pediatr Cardiol 34:1112-7. 2013
    ..210; p < 0.001). Tricuspid E/e' was not significantly associated with RVEDP or RAP. In conclusion, tricuspid E/e' does not indicate RV diastolic function but reflects the severity of PR in asymptomatic children after TOF repair...
  28. ncbi request reprint Transforming growth factor-beta in renal disease with glycogen storage disease I
    Maki Urushihara
    Department of Pediatrics, School of Medicine, University of Tokushima, and Division of Pediatrics, Tokushima Red Cross Hospital, Komatsushima City, Japan
    Pediatr Nephrol 19:676-8. 2004
    ..These data suggest that increased TGF-beta expression is involved in the pathophysiology of renal interstitial fibrosis in a patient with GSD-I...
  29. doi request reprint A case of a 6-year-old girl with anti-neutrophil cytoplasmic autoantibody-negative pauci-immune crescentic glomerulonephritis
    Maki Shimizu
    Department of Pediatrics, Takamatsu Red Cross Hospital, 4 1 3 Ban cho, Takamatsu, Kagawa 760 0017, Japan
    Clin Exp Nephrol 15:596-601. 2011
    ....
  30. ncbi request reprint Nitrite is an alternative source of NO in vivo
    Koichiro Tsuchiya
    Department of Pharmacology, The University of Tokushima School of Medicine, Tokushima, Japan
    Am J Physiol Heart Circ Physiol 288:H2163-70. 2005
    ....
  31. doi request reprint Cell membrane stretch activates intermediate-conductance Ca2+-activated K+ channels in arterial smooth muscle cells
    Yasunobu Hayabuchi
    Department of Pediatrics, School of Medicine, University of Tokushima, 3 18 15 Kuramoto cho, Tokushima, 770 8503, Japan
    Heart Vessels 26:91-100. 2011
    ..In addition, the activation is associated with extracellular Ca(2+) influx through stretch-activated nonselective cation channels, and is also modulated by the F-actin cytoskeleton and the activation of PKC...
  32. doi request reprint Low-density lipoprotein apheresis in a pediatric patient with refractory nephrotic syndrome due to focal segmental glomerulosclerosis
    Jun Oto
    Department of Emergency and Critical Care Medicine, Tokushima University Hospital, 3 18 15 Kuramoto cho, Tokushima, 770 8503, Japan
    J Anesth 23:284-7. 2009
    ..Urinary protein decreased from 2-4 g x day(-) to 0.5-1.0 g x day(-). LDL-A may be beneficial in the treatment of multidrug-resistant FSGS...
  33. doi request reprint Transient left temporal lobe lesion in Menkes disease may influence the generation of tonic spasms
    Hiromichi Ito
    Department of Pediatrics, School of Medicine, University of Tokushima, Japan
    Brain Dev 33:345-8. 2011
    ..In this case, the clinical course and ictal EEG suggested that epileptic activity from the left temporal lobe lesion may have given rise to tonic spasms...
  34. ncbi request reprint Function of the frontal lobe in autistic individuals: a proton magnetic resonance spectroscopic study
    Emiko Fujii
    Department of Pediatrics, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan
    J Med Invest 57:35-44. 2010
    ..In this investigation, we studied differences in chemical metabolites in certain brain regions between autistic patients and normal control subjects...
  35. doi request reprint Head circumference and body growth in autism spectrum disorders
    Aya Fukumoto
    Department of Pediatrics, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    Brain Dev 33:569-75. 2011
    ....
  36. doi request reprint Age-related changes in a patient with Pelizaeus-Merzbacher disease determined by repeated 1H-magnetic resonance spectroscopy
    Tatsuo Mori
    1Department of Pediatrics, Institute of Health Bioscience, The University of Tokushima Graduate School, Tokushima, Japan
    J Child Neurol 29:283-8. 2014
    ..Furthermore, the lack of change in the choline-containing compounds concentration can be useful for differentiating Pelizaeus-Merzbacher disease from other white matter disorders. ..
  37. doi request reprint Left atrial volume change throughout the cardiac cycle in children with congenital heart disease associated with increased pulmonary blood flow: evaluation using a novel left atrium-tracking method
    Miho Sakata
    Department of Pediatrics, School of Medicine, University of Tokushima, Tokushima 770 8503, Japan
    Pediatr Cardiol 34:105-11. 2013
    ..38, 0.49, and -0.35, respectively). The LAVT method is useful in the evaluation of LV diastolic function in pediatric patients with chronic LV volume overload...
  38. pmc Involvement of the intrarenal renin-angiotensin system in experimental models of glomerulonephritis
    Maki Urushihara
    Department of Pediatrics, Institute of Health Biosciences, The University of Tokushima Graduate School, Kuramoto cho 3 18 15, Tokushima, Tokushima 770 8503, Japan
    J Biomed Biotechnol 2012:601786. 2012
    ..In this paper, we focus on intrarenal RAS activation in the pathophysiology of experimental models of GN...
  39. doi request reprint Neuroimaging of stroke-like episodes in MELAS
    Hiromichi Ito
    Department of Pediatrics, School of Medicine, University of Tokushima, Japan
    Brain Dev 33:283-8. 2011
    ..We should conduct a simultaneous multimodal imaging and histological study just before and just after (within a few minutes) the onset of stroke-like episodes in an experimental animal model...
  40. pmc Expression of focal adhesion proteins in the developing rat kidney
    Sato Matsuura
    Department of Pediatrics, Institute of Health Bioscience, The University of Tokushima Graduate School, Tokushima, Japan
    J Histochem Cytochem 59:864-74. 2011
    ..In conclusion, the temporospatially regulated expression of focal adhesion proteins during kidney development might play a role in morphogenesis and cell differentiation...
  41. ncbi request reprint Accurate quantification of pulmonary artery diameter in patients with cyanotic congenital heart disease using multidetector-row computed tomography
    Yasunobu Hayabuchi
    Department of Pediatrics, University of Tokushima, Tokushima, Japan
    Am Heart J 154:783-8. 2007
    ....
  42. ncbi request reprint Somatosensory evoked potentials in attention deficit/hyperactivity disorder and tic disorder
    Masahito Miyazaki
    Department of Pediatrics, The Institute of Health Bioscience, The University of Tokushima Graduate School, Tokushima, Japan
    Clin Neurophysiol 118:1286-90. 2007
    ..Therefore, we hypothesized that they might have a common pathophysiology involving the somatosensory system, especially hyper-excitabilities of primary somatosensory area...
  43. doi request reprint Effective treatment of a 13-year-old boy with steroid-dependent ocular myasthenia gravis using tacrolimus
    Tatsuo Mori
    Department of Pediatrics, Institute of Health Bioscience, The University of Tokushima Graduate School, Tokushima, Japan
    Brain Dev 35:445-8. 2013
    ..No adverse effects of tacrolimus have been recognized. In pediatric patients with steroid-dependent ocular MG without thymectomy, tacrolimus may be a safe and effective alternative to steroid and thymectomy...
  44. doi request reprint Subclavian and pulmonary artery steal phenomenon in a patient with isolated left subclavian artery and right aortic arch
    Yasunobu Hayabuchi
    Department of Pediatrics, University of Tokushima, Tokushima, Japan
    J Clin Ultrasound 41:265-8. 2013
    ....
  45. ncbi request reprint Glomerular distribution and gelatinolytic activity of matrix metalloproteinases in human glomerulonephritis
    Maki Urushihara
    Department of Pediatrics, School of Medicine, University of Tokushima, Tokushima, Japan
    Nephrol Dial Transplant 17:1189-96. 2002
    ..However, the significance of MMPs in human GN remains obscure. In order to evaluate the role of MMPs in human GN, we examined the glomerular distribution and gelatinolytic activities of MMP-2 and MMP-9 in human GN...
  46. doi request reprint Pulmonary emphysematous changes in patients with congenital heart disease associated with increased pulmonary blood flow: evaluation using multidetector-row computed tomography
    Manal Mohamed Helmy Nabo
    Department of Pediatrics, University of Tokushima, Kuramoto Cho 3, Tokushima 770 8503, Japan
    Heart Lung Circ 20:587-92. 2011
    ..The present study aimed to evaluate the prevalence and the location of segmental emphysematous change in congenital heart disease (CHD) patients with increased pulmonary blood flow using multidetector-row computed tomography (MDCT)...
  47. ncbi request reprint Myocardial strain imaging for early detection of cardiac involvement in patients with Duchenne's progressive muscular dystrophy
    Kazuhiro Mori
    Department of Pediatrics, School of Medicine, University of Tokushima, Tokushima, Japan
    Echocardiography 24:598-608. 2007
    ..We hypothesized that this method might be useful for the early detection of subclinical myocardial involvement in DMD patients...
  48. ncbi request reprint Administration of secretin for autism alters dopamine metabolism in the central nervous system
    Yoshihiro Toda
    Department of Pediatrics, School of Medicine, University of Tokushima, 3 18 15, Kuramoto Cho, Tokushima shi, Tokushima 770 8503, Japan
    Brain Dev 28:99-103. 2006
    ..In contrast, no patient without the elevation of the BH(4) level showed improvement in the score. These findings suggest that secretin activated metabolic turnover of dopamine in the central nervous system via BH(4), improving symptoms...
  49. doi request reprint Minimum-intensity projection of multidetector-row computed tomography for assessment of pulmonary hypertension in children with congenital heart disease
    Yasunobu Hayabuchi
    Department of Pediatrics, University of Tokushima, Tokushima, Japan
    Int J Cardiol 149:192-8. 2011
    ..The present study aimed to assess the feasibility of minimum-intensity projection (minIP) images for the evaluation of pulmonary hypertension (PH) in children with congenital heart disease (CHD)...
  50. ncbi request reprint Beta1-integrins and glomerular injury
    Shoji Kagami
    Department of Pediatrics, The University of Tokushima School of Medicine, Tokushima, Japan
    J Med Invest 51:1-13. 2004
    ....
  51. doi request reprint Stenting of ductus arteriosus in a neonate with truncus arteriosus and interrupted aortic arch associated with a right aortic arch
    Miho Sakata
    Department of Pediatrics, School of Medicine University of Tokushima, 3 18 15 Kuramoto cho, Tokushima, 770 8503, Japan
    Pediatr Cardiol 30:1180-3. 2009
    ..This experience suggests that DA stenting in neonates with TA and IAA averts surgical repair during the early neonatal period...
  52. ncbi request reprint Growth of head circumference in autistic infants during the first year of life
    Aya Fukumoto
    Division of Human Development and Health Sciences, Subdivision of Human Development, Department of Pediatrics, Institute of Health Biosciences, University of Tokushima Graduate School, 3 18 15, Kuramoto Cho, Tokushima 770 8503, Japan
    J Autism Dev Disord 38:411-8. 2008
    ..The discrepancy reached a peak at 6 months, while the difference became smaller at 12 months. Body length (BL) and body weight (BW) began to increase at 3 months, although at a rate smaller than the head circumference increase...
  53. doi request reprint Autonomic function in patients with Duchenne muscular dystrophy
    Miki Inoue
    Department of Pediatrics, School of Medicine, University of Tokushima, Tokushima, Japan
    Pediatr Int 51:33-40. 2009
    ....
  54. ncbi request reprint The role of mast cells in acute tubulo-interstitial nephritis with uveitis
    Shuji Kondo
    Department of Paediatrics, School of Medicine, University of Tokushima, Kuramoto cho 3 chome, 770 8503 Tokushima, Japan
    Eur J Pediatr 162:496-9. 2003
    ....
  55. ncbi request reprint Sisters with alpha-mannosidosis and systemic lupus erythematosus
    Maki Urushihara
    Department of Paediatrics, School of Medicine, University of Tokushima, Kuramoto cho 3 chome, 770 8503 Tokushima, Japan
    Eur J Pediatr 163:192-5. 2004
    ..The sisters were both homozygous for a one bp deletion within the LAMAN gene resulting in a truncated gene product. The coincidence of alpha-mannosidosis and SLE are discussed with regard to both clinical and molecular findings...
  56. ncbi request reprint Serum concentration of heart-type fatty acid-binding protein in children and adolescents with congenital heart disease
    Yasunobu Hayabuchi
    Department of Pediatrics, University of Tokushima, Tokushima, Japan
    Circ J 75:1992-7. 2011
    ..The aim of the present study was to examine the relationships between serum H-FABP levels and pathophysiological characteristics in children and adolescents with congenital heart disease (CHD)...
  57. doi request reprint Development of systemic-to-pulmonary collateral arteries in a patient with hypoplastic left cardiac syndrome after bilateral pulmonary artery banding
    Miki Inoue
    Department of Pediatrics, University of Tokushima, Tokushima, Japan
    Cardiol Young 20:465-7. 2010
    ..The growth of collateral arteries should be evaluated carefully because bilateral pulmonary artery banding under prostaglandin E1 administration is considered an initial palliative option...
  58. ncbi request reprint Angiotensin II activates intermediate-conductance Ca2+ -activated K+ channels in arterial smooth muscle cells
    Yasunobu Hayabuchi
    Department of Pediatrics, School of Medicine, University of Tokushima, Kuramoto cho 3 18 15, Tokushima 770 8503, Japan
    J Mol Cell Cardiol 41:972-9. 2006
    ..These data suggest that Ang II activates IKca channels through the activation of protein kinase C, and the AT1 receptor is involved in the regulation of these channels...
  59. doi request reprint Rare venous connection causing severe hypoxia after Fontan operation
    Yasunobu Hayabuchi
    Department of Pediatrics, University of Tokushima, Kuramoto Cho 3, Tokushima 770 8503, Japan
    Interact Cardiovasc Thorac Surg 7:718-9. 2008
    ..Multidetector-row computed tomography (MDCT) was a useful tool to depict this vascular malformation...
  60. ncbi request reprint Favorable response of ADHD with giant SEP to extended-release valproate
    Masahito Miyazaki
    Department of Pediatrics, Institute of Health Biosciences, The University of Tokushima Graduate, Tokushima, Japan
    Brain Dev 28:470-2. 2006
    ..Improvement particularly involved hyperactivity and impulsivity. When methylphenidate previously was administered to two patients, symptoms worsened. EVA therefore may be preferable for ADHD with giant SEP...
  61. ncbi request reprint Treatment of unresectable malignant rhabdoid tumor of the orbit with tandem high-dose chemotherapy and gamma-knife radiosurgery
    Hiroyoshi Watanabe
    Department of Pediatrics, Tokushima University Hospital, Tokushima, Japan
    Pediatr Blood Cancer 47:846-50. 2006
    ..Although the tumor was not completely removed, and the initial chemotherapy failed, the patient achieved long-term survival after this modality of treatment. This approach may be one to be further considered in patients with MRT...
  62. ncbi request reprint Hydrogen peroxide stimulates c-Src-mediated big mitogen-activated protein kinase 1 (BMK1) and the MEF2C signaling pathway in PC12 cells: potential role in cell survival following oxidative insults
    Yuki Suzaki
    Department of Pharmacology, Pediatrics, Virology, and Clinical Nutrition, The University of Tokushima School of Medicine, Tokushima 770 8503, Japan
    J Biol Chem 277:9614-21. 2002
    ..These findings suggest that c-Src mediated BMK1 activation by H(2)O(2) may counteract ischemic cellular damage probably through the activation of MEF2C transcription factor...
  63. doi request reprint A novel bilayer approach to ventricular septal deformation analysis by speckle tracking imaging in children with right ventricular overload
    Yasunobu Hayabuchi
    Department of Pediatrics, University of Tokushima, Tokushima, Japan
    J Am Soc Echocardiogr 24:1205-12. 2011
    ..The aim of this study was to evaluate functional differences between the left and right sides of the ventricular septum in children with right ventricular overload...
  64. ncbi request reprint Polytetrafluoroethylene graft calcification in patients with surgically repaired congenital heart disease: evaluation using multidetector-row computed tomography
    Yasunobu Hayabuchi
    Department of Pediatrics, University of Tokushima, Tokushima, Japan
    Am Heart J 153:806.e1-8. 2007
    ....
  65. doi request reprint Serial brain imaging analysis of stroke-like episodes in MELAS
    Hiromichi Ito
    Department of Pediatrics, School of Medicine, University of Tokushima, 3 18 15, Kuramoto Cho, Tokushima 770 8503, Japan
    Brain Dev 30:483-8. 2008
    ..These results suggest that the stroke-like episodes is related to vasogenic edema, hyperperfusion, and neuronal damage. Acute oxidative phosphorylation defect may have a crucial role in the pathophysiology of stroke-like episodes...
  66. ncbi request reprint A case of Kabuki syndrome presenting West syndrome
    Hiromichi Ito
    Department of Pediatrics, Institute of Health Biosciences, The University of Tokushima Graduate School, Japan
    Brain Dev 29:380-2. 2007
    ..To the best of our knowledge, Kabuki syndrome presenting West syndrome has been reported in only one previous case. We must pay attention to the occurrence of West syndrome in Kabuki syndrome...
  67. ncbi request reprint Virtual endoscopy using multidetector-row CT for coil occlusion of patent ductus arteriosus
    Yasunobu Hayabuchi
    Department of Pediatrics, University of Tokushima, Kuramoto Cho 3, Tokushima, Japan
    Catheter Cardiovasc Interv 70:434-9. 2007
    ..Coil protrusion into the aortic and pulmonary sides was clearly observed. Virtual endoscopy provides unique information regarding the ductal lumen that is of use for the coil occlusion of PDA...
  68. ncbi request reprint Characterization of follistatin-related gene as a negative regulatory factor for activin family members during mouse heart development
    Yuka Takehara-Kasamatsu
    Institute for Enzyme Research, The University of Tokushima, Tokushima, Japan
    J Med Invest 54:276-88. 2007
    ..Our results suggest that FLRG could function as a negative regulator of activin family members including MSTN during heart development...
  69. ncbi request reprint Genetics and clinical features of 15 Asian families with steroid-resistant nephrotic syndrome
    Akiko Kitamura
    Department of Pediatrics, Institute of Health Biosciences, The University of Tokushima Graduate School, 3 18 15 Kuramoto, Tokushima 770 8503, and Department of Pediatric Nephrology, Tokyo Metropolitan Kiyose Children s Hospital, Japan
    Nephrol Dial Transplant 21:3133-8. 2006
  70. ncbi request reprint [Membranoproliferative glomerulonephritis]
    Shuji Kondo
    Department of Pediatrics, The Institute of Health Bioscience, The University of Tokushima Graduate School
    Nihon Rinsho 63:526-9. 2005
  71. ncbi request reprint Findings of brain 99mTc-ECD SPECT in high-functioning autism--3-dimensional stereotactic ROI template analysis of brain SPECT
    Hiromichi Ito
    Department of Pediatrics, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    J Med Invest 52:49-56. 2005
    ....
  72. doi request reprint Refractory pediatric nonrhabdomyosarcoma soft tissue sarcoma associated with ectopic production of beta hCG and hypercalcemia induced by PTHrP
    Nami Inoue
    Department of Pediatrics, Tokushima University Hospital, Tokushima, Japan
    Pediatr Blood Cancer 57:1244-6. 2011
    ..The tumor was refractory to multiagent chemotherapy, and the patient died of the disease at 22 months of age. This case is novel in demonstrating a beta hCG secreting refractory NRSTS...
  73. pmc Urinary angiotensinogen as a biomarker of nephropathy in childhood
    Maki Urushihara
    Department of Pediatrics, Institute of Health Biosciences, The University of Tokushima Graduate School, Kuramoto cho 3 18 15, Tokushima 770 8503, Japan
    Int J Nephrol 2011:206835. 2011
    ..These results suggest that urinary AGT reflects intrarenal RAS status in chronic GN and may be an early marker of diabetic nephropathy...
  74. pmc Genetic variations of Toll-like receptor 9 predispose to systemic lupus erythematosus in Japanese population
    Kayoko Tao
    Department of Immunology and Parasitology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3 18 15 Kuramoto, Tokushima 770 8503, Japan
    Ann Rheum Dis 66:905-9. 2007
    ..Signalling through Toll-like receptor 9 (TLR9), a mediator of innate immune responses, has a role in activation of dendritic cells and autoreactive B cells...
  75. ncbi request reprint Possible contributions of reactive oxygen species and mitogen-activated protein kinase to renal injury in aldosterone/salt-induced hypertensive rats
    Akira Nishiyama
    Department of Pharmacology, Kagawa Medical University, Kagawa, Japan
    Hypertension 43:841-8. 2004
    ..Furthermore, eplerenone and tempol treatments normalized the activities of ERK1/2, JNK, and BMK1. These data suggest that ROS and MAPK play a role in the progression of renal injury induced by chronic elevations in aldosterone...
  76. ncbi request reprint The SOD mimetic tempol ameliorates glomerular injury and reduces mitogen-activated protein kinase activity in Dahl salt-sensitive rats
    Akira Nishiyama
    Department of Pharmacology, Kagawa Medical University, Kagawa, Japan
    J Am Soc Nephrol 15:306-15. 2004
    ..These data suggest that reactive oxygen species, generated by NAD(P)H oxidase, contribute to the progression of renal injury through ERK1/ERK2 activation in DS/H hypertensive rats...
  77. doi request reprint Possible involvement of Rho-kinase in aldosterone-induced vascular smooth muscle cell remodeling
    Kayoko Miyata
    Life Sciences Research Center, Kagawa University Medical School, Kagawa, Japan
    Hypertens Res 31:1407-13. 2008
    ..These findings indicate that Rho-kinase is involved in the pathogenesis of aldosterone-induced VSMC remodeling...
  78. ncbi request reprint Dual effects of endothelin-1 (1-31): induction of mesangial cell migration and facilitation of monocyte recruitment through monocyte chemoattractant protein-1 production by mesangial cells
    Keisuke Ishizawa
    Department of Pharmacology, University of Tokushima School of Medicine, Japan
    Hypertens Res 27:433-40. 2004
    ..Since human chymase has been reported to be involved in glomerular disease, ET-1 (1-31) may be among the mediators...
  79. ncbi request reprint Short-latency somatosensory evoked potentials in infantile autism: evidence of hyperactivity in the right primary somatosensory area
    Masahito Miyazaki
    Department of Paediatrics, Miyoshi Medical Clinic, Higashikagawa, Japan
    Dev Med Child Neurol 49:13-7. 2007
    ..This is believed to contribute to the pathophysiology of infantile autism, especially the idiopathic form...