Takeshi Iwasa

Summary

Affiliation: The University of Tokushima
Country: Japan

Publications

  1. Iwasa T, Matsuzaki T, Mayila Y, Yanagihara R, Yamamoto Y, Kawakita T, et al. Oxytocin treatment reduced food intake and body fat and ameliorated obesity in ovariectomized female rats. Neuropeptides. 2019;: pubmed publisher
    ..These results indicate that oxytocin might be useful for treating or preventing menopause-induced metabolic disorders, without causing any adverse effects. ..
  2. Iwasa T, Matsuzaki T, Yano K, Mayila Y, Yanagihara R, Yamamoto Y, et al. Prenatal undernutrition affects the phenotypes of PCOS model rats. J Endocrinol. 2018;: pubmed publisher
  3. Iwasa T, Matsuzaki T, Gereltsetseg G, Munkhzaya M, Tungalagsurv A, Murakami M, et al. Site-specific changes in cytokine response to septic dose of lipopolysaccharide in ovariectomized female rats. J Endocrinol Invest. 2014;37:721-727 pubmed publisher
    ..As hypothalamic, but not peripheral, pro-inflammatory cytokines are directly involved in the fever response, the attenuation of fever response observed in ovariectomized rats may be caused by a reduction in central cytokine responses. ..
  4. Iwasa T, Matsuzaki T, Yano K, Mayila Y, Irahara M. Prenatal undernutrition decreases the anorectic response to septic doses of lipopolysaccharides in adulthood in male rats. Int J Dev Neurosci. 2018;69:39-43 pubmed publisher
    ..The downregulation of hypothalamic stress-related factor expression might be involved in such attenuated stress responses, which could be one of the protective mechanisms used to prevent excessive immune responses and aid survival. ..
  5. Iwasa T, Matsuzaki T, Matsui S, Tungalagsuvd A, Munkhzaya M, Kawami T, et al. The effects of ovariectomy and LPS-induced endotoxemia on resistin levels in female rats. Cytokine. 2015;76:558-560 pubmed publisher
    ..These results suggest that ovarian hormones partially regulate the basal resistin levels of female rats. ..
  6. Iwasa T, Matsuzaki T, Tungalagsuvd A, Munkhzaya M, Kuwahara A, Yasui T, et al. LH and testosterone production are more sensitive to the suppressive effects of food deprivation in prenatally undernourished male rats. Int J Dev Neurosci. 2015;43:66-9 pubmed publisher
    ..Changes of serum leptin level, but not of hypothalamic reproductive related factors, might be involved in these alterations. However, the precise mechanisms responsible for these effects remain unclear. ..
  7. Iwasa T, Matsuzaki T, Tungalagsuvd A, Munkhzaya M, Kawami T, Yamasaki M, et al. Developmental changes in hypothalamic toll-like-receptor 4 mRNA expression and the effects of lipopolysaccharide on such changes in female rats. Int J Dev Neurosci. 2015;40:12-4 pubmed publisher
    ..Thus, it is assumed that hypothalamic TLR4 hypoactivity contributes to the low sensitivity of pro-inflammatory cytokines to LPS during the early developmental period. ..
  8. Iwasa T, Matsuzaki T, Munkhzaya M, Tungalagsuvd A, Yamasaki M, Kuwahara A, et al. The effects of prenatal undernutrition and postnatal high-fat diet on hypothalamic Kiss1 mRNA and serum leptin levels. Int J Dev Neurosci. 2015;42:76-9 pubmed publisher
    ..They also suggest that the relationships between nutritional conditions, body weight, reproductive factors, and sexual maturation are complex. ..
  9. Iwasa T, Matsuzaki T, Yano K, Mayila Y, Yanagihara R, Yamamoto Y, et al. Effects of Low Energy Availability on Reproductive Functions and Their Underlying Neuroendocrine Mechanisms. J Clin Med. 2018;7: pubmed publisher
    ..This paper presents a review of what is currently known about the effects of metabolic status on reproductive functions and their underlying mechanisms by summarizing the available evidence. ..

More Information

Publications25

  1. Iwasa T, Matsuzaki T, Tungalagsuvd A, Munkhzaya M, Kawami T, Kato T, et al. Effects of ovariectomy on the inflammatory responses of female rats to the central injection of lipopolysaccharide. J Neuroimmunol. 2014;277:50-6 pubmed publisher
    ..As is seen in other obese animal models, ovariectomy-induced obesity might play important roles in the exacerbated inflammatory responses observed in ovariectomized rats. ..
  2. Iwasa T, Matsuzaki T, Tungalagsuvd A, Munkhzaya M, Kuwahara A, Yasui T, et al. Prenatal undernutrition increases the febrile response to lipopolysaccharides in adulthood in male rats. Int J Dev Neurosci. 2015;44:1-5 pubmed publisher
    ..These results suggest that prenatal undernutrition has long-lasting effects on the febrile response to LPS. However, the precise mechanism underlying these effects and their pathophysiological significance remain unclear. ..
  3. Iwasa T, Matsuzaki T, Tungalagsuvd A, Munkhzaya M, Yiliyasi M, Kato T, et al. Prenatal undernutrition results in greater lipopolysaccharide-induced changes in hypothalamic TNF-α expression, but does not affect the equivalent changes in the serum levels of luteinizing hormone and testosterone, in adult male rats. Int J Dev Neurosci. 2016;48:80-3 pubmed publisher
    ..These results suggest that prenatal undernutrition results in more marked LPS-induced changes in hypothalamic TNF-α expression, but does not alter the effects of LPS on the serum levels of LH or testosterone, in adult male rats. ..
  4. Iwasa T, Matsuzaki T, Tungalagsuvd A, Munkhzaya M, Yiliyasi M, Kuwahara A, et al. Developmental changes in the hypothalamic mRNA levels of nucleobindin-2 (NUCB2) and their sensitivity to fasting in male and female rats. Int J Dev Neurosci. 2016;49:46-9 pubmed publisher
    ..However, hypothalamic NUCB2 mRNA expression does not become sensitive to a negative energy balance during the neonatal to pre-pubertal period. ..
  5. Saito K, Matsuzaki T, Iwasa T, Miyado M, Saito H, Hasegawa T, et al. Steroidogenic pathways involved in androgen biosynthesis in eumenorrheic women and patients with polycystic ovary syndrome. J Steroid Biochem Mol Biol. 2016;158:31-37 pubmed publisher
    ..e., an androstanedione-mediated pathway and a so-called backdoor pathway, likely serve as sources of a weak androgen and potential precursors of DHT. ..
  6. Iwasa T, Matsuzaki T, Yano K, Yiliyasi M, Kuwahara A, Matsui S, et al. Effects of chronic testosterone administration on the degree of preference for a high-fat diet and body weight in gonadal-intact and ovariectomized female rats. Behav Brain Res. 2018;349:102-108 pubmed publisher
    ..Testosterone-induced changes in hypothalamic inflammatory cytokine production and ER stress might be related to these findings. ..
  7. Iwasa T, Matsuzaki T, Yano K, Munkhzaya M, Tungalagsuvd A, Yiliyasi M, et al. Developmental changes in the hypothalamic mRNA expression levels of brain-derived neurotrophic factor and serum leptin levels: Their responses to fasting in male and female rats. Int J Dev Neurosci. 2016;54:1-5 pubmed publisher
  8. Iwasa T, Matsuzaki T, Munkhzaya M, Tungalagsuvd A, Kawami T, Murakami M, et al. Changes in the responsiveness of hypothalamic prokineticin 2 mRNA expression to food deprivation in developing female rats. Int J Dev Neurosci. 2014;34:76-8 pubmed publisher
    ..These results suggest that the sensitivity of hypothalamic PK2 expression to undernutrition develops during the early neonatal period, when the responses of other appetite regulatory factors to such pressures remain immature. ..
  9. Iwasa T, Matsuzaki T, Yano K, Irahara M. The effects of ovariectomy and lifelong high-fat diet consumption on body weight, appetite, and lifespan in female rats. Horm Behav. 2018;97:25-30 pubmed publisher
    ..These findings indicate that the alterations in body weight and energy metabolism induced by ovariectomy and high-fat diet might not directly affect the lifespan of female rats. ..
  10. Iwasa T, Matsuzaki T, Yiliyasi M, Yano K, Irahara M. The effects of chronic testosterone administration on body weight, food intake, and fat weight were age-dependent. Steroids. 2017;127:18-23 pubmed publisher
    ..Testosterone might disrupt the mechanisms that protect against adiposity and hyperphagia and represent a risk factor for excessive body weight and obesity, especially in older females. ..
  11. Iwasa T, Matsuzaki T, Tungalagsuvd A, Munkhzaya M, Yiliyasi M, Kato T, et al. Developmental changes in the hypothalamic mRNA expression levels of PACAP and its receptor PAC1 and their sensitivity to fasting in male and female rats. Int J Dev Neurosci. 2016;52:33-7 pubmed publisher
    ..The mechanisms responsible for and the physiological effects of such changes in hypothalamic PACAP and PAC1 expression during the developmental period remain to be clarified. ..
  12. Iwasa T, Matsuzaki T, Tungalagsuvd A, Munkhzaya M, Yiliyasi M, Kato T, et al. Effects of chronic testosterone administration on body weight and food intake differ among pre-pubertal, gonadal-intact, and ovariectomized female rats. Behav Brain Res. 2016;309:35-43 pubmed publisher
  13. Iwasa T, Matsuzaki T, Munkhzaya M, Tungalagsuvd A, Kuwahara A, Yasui T, et al. Developmental changes in the hypothalamic mRNA levels of prepro-orexin and orexin receptors and their sensitivity to fasting in male and female rats. Int J Dev Neurosci. 2015;46:51-4 pubmed publisher
    ..These differences might be involved in the development of some physiological and behavioral functions. ..
  14. Iwasa T, Matsuzaki T, Yano K, Yanagihara R, Tungalagsuvd A, Munkhzaya M, et al. The effects of chronic testosterone administration on body weight, food intake, and adipose tissue are changed by estrogen treatment in female rats. Horm Behav. 2017;93:53-61 pubmed publisher
    ..Differences in the responses of hypothalamic factors, such as aromatase and inflammatory cytokines, to testosterone might underlie these opposite effects. ..
  15. Iwasa T, Matsuzaki T, Matsui S, Tungalagsuvd A, Munkhzaya M, Takiguchi E, et al. The sensitivity of adipose tissue visfatin mRNA expression to lipopolysaccharide-induced endotoxemia is increased by ovariectomy in female rats. Int Immunopharmacol. 2016;35:243-247 pubmed publisher
    ..In addition, the precise mechanisms responsible for the increased WAT visfatin expression seen after ovariectomy and the effects of such changes should also be clarified. ..
  16. Iwasa T, Matsuzaki T, Tungalagsuvd A, Munkhzaya M, Kawami T, Yamasaki M, et al. Changes in the responsiveness of hypothalamic PK2 and PKR1 gene expression to fasting in developing male rats. Int J Dev Neurosci. 2014;38:87-90 pubmed publisher
    ..It can be speculated that the PK2 system might compensate for the immaturity of other appetite regulatory factors in the early neonatal period. ..