Affiliation: The University of Tokushima
Hosokawa Y, Hosokawa I, Shindo S, Ozaki K, Matsuo T. (-)-Epigallocatechin-3-gallate inhibits CC chemokine ligand 11 production in human gingival fibroblasts. Cell Physiol Biochem. 2013;31:960-7 pubmed publisher
..These data provide that CCL11 production in HGFs could be associated with Th2 cells infiltration in periodontal lesions. Moreover, EGCG is useful for periodontitis treatment to inhibit CCL11 production. ..
Hosokawa Y, Hosokawa I, Shindo S, Ozaki K, Nakae H, Matsuo T. Tumor necrosis factor-like weak inducer of apoptosis increases CC chemokine ligand 20 production in interleukin 1?-stimulated human gingival fibroblasts. Hum Immunol. 2012;73:470-3 pubmed publisher
..These data suggest that TWEAK is positively related to Th17 cell migration in periodontally diseased tissues to enhance CCL20 production in IL-1?-stimulated HGFs. ..
Hosokawa I, Hosokawa Y, Ozaki K, Nakae H, Matsuo T. Adrenomedullin suppresses tumour necrosis factor alpha-induced CXC chemokine ligand 10 production by human gingival fibroblasts. Clin Exp Immunol. 2008;152:568-75 pubmed publisher
..AM might be a therapeutic target of periodontal disease, because AM can inhibit CXCL10 production by HGFs. ..
Hosokawa Y, Hosokawa I, Ozaki K, Nakae H, Matsuo T. Human gingival fibroblasts express functional chemokine receptor CXCR6. Clin Exp Immunol. 2009;156:413-8 pubmed publisher
..These results indicate that CXCL16 may play an important role in the pathogenesis and remodelling in periodontally diseased tissues. ..
Hosokawa Y, Hosokawa I, Ozaki K, Nakanishi T, Nakae H, Matsuo T. Tea polyphenols inhibit IL-6 production in tumor necrosis factor superfamily 14-stimulated human gingival fibroblasts. Mol Nutr Food Res. 2010;54 Suppl 2:S151-8 pubmed publisher
..In addition, EGCG, ECG, and TFDG attenuated TNFSF14 receptor expression on HGFs. These data provide a novel mechanism through which the green tea and black tea polyphenols could be used to provide direct benefits in periodontal disease. ..
Hosokawa I, Hosokawa Y, Ozaki K, Yumoto H, Nakae H, Matsuo T. Proinflammatory effects of muramyldipeptide on human gingival fibroblasts. J Periodontal Res. 2010;45:193-9 pubmed publisher
..These findings indicate that MDP which induces production of cytokines and chemokines from HGFs is related to the pathogenesis of periodontal disease. ..
Hosokawa Y, Hosokawa I, Ozaki K, Nakae H, Matsuo T. Increase of CCL20 expression by human gingival fibroblasts upon stimulation with cytokines and bacterial endotoxin. Clin Exp Immunol. 2005;142:285-91 pubmed
..Thus, CCL20 by HGF might be involved in inflammatory cells infiltration, and promote the progression of periodontal disease. ..
Hosokawa Y, Hosokawa I, Ozaki K, Nakae H, Matsuo T. TNFSF14 coordinately enhances CXCL10 and CXCL11 productions from IFN-gamma-stimulated human gingival fibroblasts. Mol Immunol. 2010;47:666-70 pubmed publisher
..These effects of TNFSF14 may promote the infiltration of Th1 cells into lesions with inflammatory diseases. TNFSF14 might act as a proinflammatory cytokine in some inflammatory diseases thus is a candidate therapeutic target. ..
Hosokawa Y, Hosokawa I, Ozaki K, Nakae H, Matsuo T. Interleukin (IL)-17A synergistically enhances CC chemokine ligand 20 production in IL-1?-stimulated human gingival fibroblasts. Hum Immunol. 2012;73:26-30 pubmed publisher
..Therefore, IL-1? might be a therapeutic target for Th17-related diseases, such as periodontal disease and arthritis. ..