H Akari

Summary

Affiliation: The University of Tokushima
Country: Japan

Publications

  1. ncbi Selective expression of beta 7 integrin on lymphocytes undergoing apoptosis in lymphoid tissues
    H Akari
    Department of Virology, School of Medicine, University of Tokushima, Japan
    Biochem Biophys Res Commun 244:578-82. 1998
  2. ncbi Induction of MHC-IIDR expression on circulating CD8+ lymphocytes in macaques infected with SIVmac239 nef-open but not with its nef-deletion mutant
    H Akari
    Tsukuba Primate Center, National Institute of Infectious Diseases, Ibaraki, Japan
    AIDS Res Hum Retroviruses 14:619-25. 1998
  3. pmc Nef-induced major histocompatibility complex class I down-regulation is functionally dissociated from its virion incorporation, enhancement of viral infectivity, and CD4 down-regulation
    H Akari
    Department of Virology, The University of Tokushima School of Medicine, Tokushima, Tokushima 770 8503, Japan
    J Virol 74:2907-12. 2000
  4. ncbi Simian T cell leukemia virus type I-induced malignant adult T cell leukemia-like disease in a naturally infected African green monkey: implication of CD8+ T cell leukemia
    H Akari
    Tsukuba Primate Center, National Institute of Infectious Diseases, Ibaraki, Japan
    AIDS Res Hum Retroviruses 14:367-71. 1998
  5. pmc Cyclophilin A-independent replication of a human immunodeficiency virus type 1 isolate carrying a small portion of the simian immunodeficiency virus SIV(MAC) gag capsid region
    M Fujita
    Department of Virology, The University of Tokushima School of Medicine, Tokushima shi, Tokushima 770 8503, Japan
    J Virol 75:10527-31. 2001
  6. ncbi The human immunodeficiency virus type 1 Vpu protein inhibits NF-kappa B activation by interfering with beta TrCP-mediated degradation of Ikappa B
    S Bour
    Laboratory of Molecular Microbiology, NIAID, National Institutes of Health, Bethesda, Maryland 20892 0460, USA
    J Biol Chem 276:15920-8. 2001
  7. pmc The human immunodeficiency virus type 1 accessory protein Vpu induces apoptosis by suppressing the nuclear factor kappaB-dependent expression of antiapoptotic factors
    H Akari
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 194:1299-311. 2001
  8. pmc Human immunodeficiency virus type 1 Vif protein is packaged into the nucleoprotein complex through an interaction with viral genomic RNA
    M A Khan
    Laboratory of Molecular Microbiology, Viral Biochemistry Section, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892-0460, USA
    J Virol 75:7252-65. 2001

Collaborators

Detail Information

Publications8

  1. ncbi Selective expression of beta 7 integrin on lymphocytes undergoing apoptosis in lymphoid tissues
    H Akari
    Department of Virology, School of Medicine, University of Tokushima, Japan
    Biochem Biophys Res Commun 244:578-82. 1998
    ..These findings indicate that in the lymphoid tissues the shrunken lymphocytes undergoing apoptosis selectively express a unique beta 7 integrin...
  2. ncbi Induction of MHC-IIDR expression on circulating CD8+ lymphocytes in macaques infected with SIVmac239 nef-open but not with its nef-deletion mutant
    H Akari
    Tsukuba Primate Center, National Institute of Infectious Diseases, Ibaraki, Japan
    AIDS Res Hum Retroviruses 14:619-25. 1998
    ..These data indicate that the evaluation of activation markers such as DR and/or CD69 on circulating CD8+ cells may be valuable as a surrogate marker in the SIV-macaque model...
  3. pmc Nef-induced major histocompatibility complex class I down-regulation is functionally dissociated from its virion incorporation, enhancement of viral infectivity, and CD4 down-regulation
    H Akari
    Department of Virology, The University of Tokushima School of Medicine, Tokushima, Tokushima 770 8503, Japan
    J Virol 74:2907-12. 2000
    ....
  4. ncbi Simian T cell leukemia virus type I-induced malignant adult T cell leukemia-like disease in a naturally infected African green monkey: implication of CD8+ T cell leukemia
    H Akari
    Tsukuba Primate Center, National Institute of Infectious Diseases, Ibaraki, Japan
    AIDS Res Hum Retroviruses 14:367-71. 1998
    ..However, in the case of in vitro-transformed cell lines the expression pattern of the CD8 chains varied in individual monkeys. Thus, STLV-I may preferentially transform CD8+ (both alphaalpha+ and alphabeta+) T cells in AGMs...
  5. pmc Cyclophilin A-independent replication of a human immunodeficiency virus type 1 isolate carrying a small portion of the simian immunodeficiency virus SIV(MAC) gag capsid region
    M Fujita
    Department of Virology, The University of Tokushima School of Medicine, Tokushima shi, Tokushima 770 8503, Japan
    J Virol 75:10527-31. 2001
    ..These results indicate that the transfer of a small portion of the SIV(MAC) CA region to HIV-1 could confer the CyPA-independent replication potential of SIV(MAC) on the virus...
  6. ncbi The human immunodeficiency virus type 1 Vpu protein inhibits NF-kappa B activation by interfering with beta TrCP-mediated degradation of Ikappa B
    S Bour
    Laboratory of Molecular Microbiology, NIAID, National Institutes of Health, Bethesda, Maryland 20892 0460, USA
    J Biol Chem 276:15920-8. 2001
    ..However, in the presence of Vpu, this HIV-mediated NF-kappaB activation was markedly reduced. These results suggest that Vpu modulates both virus- and cytokine-induced activation of NF-kappaB in HIV-1-infected cells...
  7. pmc The human immunodeficiency virus type 1 accessory protein Vpu induces apoptosis by suppressing the nuclear factor kappaB-dependent expression of antiapoptotic factors
    H Akari
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 194:1299-311. 2001
    ..Thus, Vpu induces apoptosis through activation of the caspase pathway by way of inhibiting the NF-kappaB-dependent expression of antiapoptotic genes...
  8. pmc Human immunodeficiency virus type 1 Vif protein is packaged into the nucleoprotein complex through an interaction with viral genomic RNA
    M A Khan
    Laboratory of Molecular Microbiology, Viral Biochemistry Section, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892-0460, USA
    J Virol 75:7252-65. 2001
    ..Our data suggest that the specific association of Vif with the viral nucleoprotein complex might be functionally significant and could be a critical requirement for infectivity of viruses produced from restrictive host cells...