Ken ichi Aihara

Summary

Affiliation: The University of Tokushima
Country: Japan

Publications

  1. pmc Effects of statins on cardiorenal syndrome
    Shusuke Yagi
    Department of Cardiovascular Medicine, The University of Tokushima Graduate School of Health Biosciences, 3 18 15 Kuramoto cho, Tokushima 770 8503, Japan
    Int J Vasc Med 2012:162545. 2012
  2. ncbi request reprint Heparin cofactor II attenuates vascular remodeling in humans and mice
    Ken ichi Aihara
    Department of Medicine and Bioregulatory Sciences, The University of Tokushima, Graduate School of Health Biosciences, Tokushima, Japan
    Circ J 74:1518-23. 2010
  3. ncbi request reprint Heparin cofactor II as a novel vascular protective factor against atherosclerosis
    Ken ichi Aihara
    Department of Medicine and Bioregulatory Sciences, The University of Tokushima, Graduate School of Health Biosciences, Tokushima, Japan
    J Atheroscler Thromb 16:523-31. 2009
  4. ncbi request reprint Disruption of nuclear vitamin D receptor gene causes enhanced thrombogenicity in mice
    Ken ichi Aihara
    Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Medicine, Japan
    J Biol Chem 279:35798-802. 2004
  5. ncbi request reprint Heparin cofactor II is an independent protective factor against peripheral arterial disease in elderly subjects with cardiovascular risk factors
    Ken ichi Aihara
    Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Health Biosciences, Tokushima, Japan
    J Atheroscler Thromb 16:127-34. 2009
  6. doi request reprint Androgen receptor counteracts Doxorubicin-induced cardiotoxicity in male mice
    Yasumasa Ikeda
    Department of Medicine and Bioregulatory Sciences, The University of Tokushima Graduate School of Health Biosciences, Tokushima 770 8503, Japan
    Mol Endocrinol 24:1338-48. 2010
  7. doi request reprint Heparin cofactor II protects against angiotensin II-induced cardiac remodeling via attenuation of oxidative stress in mice
    Yuka Sumitomo-Ueda
    Department of Medicine and Bioregulatory Sciences, The University of Tokushima Graduate School of Health Biosciences, 3 18 15 Kuramoto cho, Tokushima 770 8503, Japan
    Hypertension 56:430-6. 2010
  8. doi request reprint Endothelial nitric oxide synthase-independent protective action of statin against angiotensin II-induced atrial remodeling via reduced oxidant injury
    Shusuke Yagi
    Department of Cardiovascular Medicine, University of Tokushima Graduate School of Health Biosciences, 3 18 15 Kuramoto cho, Tokushima 770 8503, Japan
    Hypertension 55:918-23. 2010
  9. doi request reprint Bovine milk-derived lactoferrin exerts proangiogenic effects in an Src-Akt-eNOS-dependent manner in response to ischemia
    Yasumasa Ikeda
    Department of Pharmacology, University of Tokushima Graduate School of Health Biosciences, Tokushima, Japan
    J Cardiovasc Pharmacol 61:423-9. 2013
  10. pmc Heparin cofactor II, a serine protease inhibitor, promotes angiogenesis via activation of the AMP-activated protein kinase-endothelial nitric-oxide synthase signaling pathway
    Yasumasa Ikeda
    Department of Pharmacology, University of Tokushima Graduate School of Health Biosciences, 3 18 15 Kuramoto cho, Tokushima 770 8503, Japan
    J Biol Chem 287:34256-63. 2012

Collaborators

Detail Information

Publications42

  1. pmc Effects of statins on cardiorenal syndrome
    Shusuke Yagi
    Department of Cardiovascular Medicine, The University of Tokushima Graduate School of Health Biosciences, 3 18 15 Kuramoto cho, Tokushima 770 8503, Japan
    Int J Vasc Med 2012:162545. 2012
    ....
  2. ncbi request reprint Heparin cofactor II attenuates vascular remodeling in humans and mice
    Ken ichi Aihara
    Department of Medicine and Bioregulatory Sciences, The University of Tokushima, Graduate School of Health Biosciences, Tokushima, Japan
    Circ J 74:1518-23. 2010
    ..HCII protects against vascular remodeling, including atherosclerosis, in both humans and mice, and plasma HCII activity might be a predictive biomarker and novel therapeutic target for the prevention of cardiovascular diseases...
  3. ncbi request reprint Heparin cofactor II as a novel vascular protective factor against atherosclerosis
    Ken ichi Aihara
    Department of Medicine and Bioregulatory Sciences, The University of Tokushima, Graduate School of Health Biosciences, Tokushima, Japan
    J Atheroscler Thromb 16:523-31. 2009
    ..These results demonstrate that HCII protects against thrombin-induced vascular remodeling in both humans and mice and suggest that HCII is a predictive biomarker and therapeutic target for atherosclerosis...
  4. ncbi request reprint Disruption of nuclear vitamin D receptor gene causes enhanced thrombogenicity in mice
    Ken ichi Aihara
    Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Medicine, Japan
    J Biol Chem 279:35798-802. 2004
    ..These results demonstrate that activation of nuclear VDR elicits antithrombotic effects in vivo, and suggest that the VDR system may play a physiological role in the maintenance of antithrombotic homeostasis...
  5. ncbi request reprint Heparin cofactor II is an independent protective factor against peripheral arterial disease in elderly subjects with cardiovascular risk factors
    Ken ichi Aihara
    Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Health Biosciences, Tokushima, Japan
    J Atheroscler Thromb 16:127-34. 2009
    ....
  6. doi request reprint Androgen receptor counteracts Doxorubicin-induced cardiotoxicity in male mice
    Yasumasa Ikeda
    Department of Medicine and Bioregulatory Sciences, The University of Tokushima Graduate School of Health Biosciences, Tokushima 770 8503, Japan
    Mol Endocrinol 24:1338-48. 2010
    ..Thus, the androgen-AR system is thought to counteract Dox-induced cardiotoxicity partly through activation of the Akt pathway and up-regulation of Tfam to protect cardiomyocytes from mitochondrial damage and apoptosis...
  7. doi request reprint Heparin cofactor II protects against angiotensin II-induced cardiac remodeling via attenuation of oxidative stress in mice
    Yuka Sumitomo-Ueda
    Department of Medicine and Bioregulatory Sciences, The University of Tokushima Graduate School of Health Biosciences, 3 18 15 Kuramoto cho, Tokushima 770 8503, Japan
    Hypertension 56:430-6. 2010
    ..The results indicate that HCII has a protective role against Ang II-induced cardiac remodeling through suppression of the NAD(P)H oxidase-transforming growth factor-beta1 pathway...
  8. doi request reprint Endothelial nitric oxide synthase-independent protective action of statin against angiotensin II-induced atrial remodeling via reduced oxidant injury
    Shusuke Yagi
    Department of Cardiovascular Medicine, University of Tokushima Graduate School of Health Biosciences, 3 18 15 Kuramoto cho, Tokushima 770 8503, Japan
    Hypertension 55:918-23. 2010
    ..In conclusion, pitavastatin exerts endothelial NO synthase-independent protective actions against Ang II-induced atrial remodeling and atrial fibrillation with enhanced thrombogenicity through suppression of oxidant injury...
  9. doi request reprint Bovine milk-derived lactoferrin exerts proangiogenic effects in an Src-Akt-eNOS-dependent manner in response to ischemia
    Yasumasa Ikeda
    Department of Pharmacology, University of Tokushima Graduate School of Health Biosciences, Tokushima, Japan
    J Cardiovasc Pharmacol 61:423-9. 2013
    ..Thus, bLF promotes vascular endothelial cell function via an Src Akt eNOS-dependent pathway, thereby contributing to revascularization in response to ischemia...
  10. pmc Heparin cofactor II, a serine protease inhibitor, promotes angiogenesis via activation of the AMP-activated protein kinase-endothelial nitric-oxide synthase signaling pathway
    Yasumasa Ikeda
    Department of Pharmacology, University of Tokushima Graduate School of Health Biosciences, 3 18 15 Kuramoto cho, Tokushima 770 8503, Japan
    J Biol Chem 287:34256-63. 2012
    ..These findings suggest that HCII is a novel therapeutic target for treatment of patients with peripheral circulation insufficiency...
  11. ncbi request reprint Androgen receptor gene knockout male mice exhibit impaired cardiac growth and exacerbation of angiotensin II-induced cardiac fibrosis
    Yasumasa Ikeda
    Department of Medicine and Bioregulatory Sciences, Institute of Health Biosciences, The University of Tokushima Graduate School, Japan
    J Biol Chem 280:29661-6. 2005
    ..These results suggest that, in male mice, the androgen-AR system participates in normal cardiac growth and modulates cardiac adaptive hypertrophy and fibrosis during the process of cardiac remodeling under hypertrophic stress...
  12. ncbi request reprint Heparin cofactor II is a novel protective factor against carotid atherosclerosis in elderly individuals
    Ken ichi Aihara
    Department of Medicine and Bioregulatory Sciences, University of Tokushima, Graduate School of Medicine, Kuramoto cho Tokushima, Japan
    Circulation 109:2761-5. 2004
    ..We hypothesized that plasma HCII activity is a preventive factor against atherosclerotic changes, especially in elderly individuals who already have atherosclerotic vascular injuries...
  13. ncbi request reprint Pitavastatin, an HMG-CoA reductase inhibitor, exerts eNOS-independent protective actions against angiotensin II induced cardiovascular remodeling and renal insufficiency
    Shusuke Yagi
    Department of Medicine and Bioregulatory Sciences, The University of Tokushima Graduate School of Health Biosciences, 3 18 15 Kuramoto cho, Tokushima 770 8503, Japan
    Circ Res 102:68-76. 2008
    ....
  14. doi request reprint Androgen receptor promotes sex-independent angiogenesis in response to ischemia and is required for activation of vascular endothelial growth factor receptor signaling
    Sumiko Yoshida
    Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Health Biosciences, 3 18 15 Kuramoto cho Tokushima 770 8503, Japan
    Circulation 128:60-71. 2013
    ..Because actions of androgens are exerted through androgen receptor (AR) activation, we studied hind-limb ischemia in AR knockout mice to elucidate the role of AR in response to ischemia...
  15. pmc Strain-dependent embryonic lethality and exaggerated vascular remodeling in heparin cofactor II-deficient mice
    Ken ichi Aihara
    Department of Medicine and Bioregulatory Sciences and 21st Century Center of Excellence Program, The University of Tokushima Graduate School of Health Biosciences, Tokushima, Japan
    J Clin Invest 117:1514-26. 2007
    ....
  16. doi request reprint Nitrosonifedipine ameliorates angiotensin II-induced vascular remodeling via antioxidative effects
    Takumi Sakurada
    Department of Pharmacology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3 18 15, Kuramoto, Tokushima, 770 8503, Japan
    Naunyn Schmiedebergs Arch Pharmacol 386:29-39. 2013
    ..These findings suggest that NO-NIF improves Ang II-induced vascular remodeling via the attenuation of oxidative stress...
  17. doi request reprint Plasma heparin cofactor II activity is inversely associated with left atrial volume and diastolic dysfunction in humans with cardiovascular risk factors
    Takayuki Ise
    Department of Medicine and Bioregulatory Sciences, The University of Tokushima Graduate School of Health Biosciences, 3 18 15 Kuramoto cho, Tokushima, Japan
    Hypertens Res 34:225-31. 2011
    ..These findings suggest that cardiac tissue thrombin inactivation by HCII is a novel therapeutic target for cardiac remodeling and atherosclerosis...
  18. doi request reprint Effect of low-dose (1 mg/day) pitavastatin on left ventricular diastolic function and albuminuria in patients with hyperlipidemia
    Shusuke Yagi
    Department of Cardiovascular Medicine, University of Tokushima Graduate School of Health Biosciences, Tokushima, Japan
    Am J Cardiol 107:1644-9. 2011
    ..In conclusion, pitavastatin decreases E/e' and albuminuria, which is associated with suppression of oxidative stress...
  19. doi request reprint High plasma aldosterone concentration is a novel risk factor of cognitive impairment in patients with hypertension
    Shusuke Yagi
    Department of Cardiovascular Medicine, The University of Tokushima Graduate School of Health Biosciences, Tokushima, Japan
    Hypertens Res 34:74-8. 2011
    ..In conclusion, increased PAC is associated with impaired cognitive function and mineral corticoid receptor blockade may protect against not only cardiovascular mortality, but also cognitive impairment in patients with hypertension...
  20. ncbi request reprint Activation of peroxisome proliferator-activated receptor α in megakaryocytes reduces platelet-derived growth factor-BB in platelets
    Shunji Hashizume
    Department of Medicine and Bioregulatory Sciences, The University of Tokushima Graduate School of Health Biosciences, Tokushima, Japan
    J Atheroscler Thromb 18:138-47. 2011
    ..The objective of this study was to clarify the pleiotropic effect of peroxisome proliferator-activated receptor α (PPARα) activators on PDGF-BB expression in megakaryocytes and platelets...
  21. ncbi request reprint Decrease in plasma brain natriuretic peptide level in the early phase after the start of carvedilol therapy is a novel predictor of long-term outcome in patients with chronic heart failure
    Mitsunori Fujimura
    Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Health Biosciences, Tokushima, Japan
    Acta Cardiol 64:589-95. 2009
    ....
  22. ncbi request reprint Infective endocarditis caused by lactobacillus
    Shusuke Yagi
    Department of Medicine and Bioregulatory Sciences, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima
    Intern Med 47:1113-6. 2008
    ..We report the onset of IE after otologic treatment in a heavy drinker of alcohol, the second case of IE due to LB in Japan...
  23. ncbi request reprint High plasma heparin cofactor II activity is associated with reduced incidence of in-stent restenosis after percutaneous coronary intervention
    Nobuyuki Takamori
    Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Medicine, Japan
    Circulation 109:481-6. 2004
    ..We hypothesized that patients with high plasma HCII activity may show a reduced incidence of in-stent restenosis (ISR)...
  24. doi request reprint Effects of androgens on cardiovascular remodeling
    Yasumasa Ikeda
    Department of Pharmacology, The University of Tokushima, Graduate School of Health Biosciences, 3 18 15 Kuramoto cho, Tokushima 770 8503, Japan
    J Endocrinol 214:1-10. 2012
    ..In this review, we focus on the actions of androgens as potential targets for the prevention of cardiovascular diseases in males...
  25. ncbi request reprint Ezetimibe monotherapy ameliorates vascular function in patients with hypercholesterolemia through decreasing oxidative stress
    Hirotsugu Kurobe
    Department of Cardiovascular Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    J Atheroscler Thromb 18:1080-9. 2011
    ..However, anti-atherogenic effects of ezetimibe have not been fully elucidated. Therefore, the objective in this study was to clarify the vascular protective effects of ezetimibe in patients with hypercholesterolemia...
  26. ncbi request reprint Ezetimibe ameliorates metabolic disorders and microalbuminuria in patients with hypercholesterolemia
    Shusuke Yagi
    Department of Cardiovascular Medicine, The University of Tokushima Graduate School of Health Biosciences, Tokushima, Japan
    J Atheroscler Thromb 17:173-80. 2010
    ..We investigated whether it also has beneficial effects on metabolic disorder and/or renal insufficiency in patients with hypercholesterolemia...
  27. doi request reprint Dehydroepiandrosterone sulfate is inversely associated with sex-dependent diverse carotid atherosclerosis regardless of endothelial function
    Sumiko Yoshida
    Department of Medicine and Bioregulatory Sciences, The University of Tokushima Graduate School of Health Biosciences, 3 18 15 Kuramoto cho, Tokushima 770 8503, Japan
    Atherosclerosis 212:310-5. 2010
    ..Therefore, the aim of this study was to determine whether DHEAS is associated with development of carotid atherosclerosis in subjects with cardiovascular risk factors...
  28. doi request reprint Serum carboxy-terminal telopeptide of type I collagen (ICTP) as a surrogate marker for vulnerable plaques in atherosclerotic patients: a pilot study
    Shuji Kato
    Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Medical Sciences, 3 18 15 Kuramoto cho, Tokushima 770 8503, Japan
    Atherosclerosis 229:182-5. 2013
    ..Only serum ICTP was positively correlated with necrotic core area by multivariate analysis (p < 0.05). These results suggest that serum ICTP can be used as a non-invasive marker of vulnerable plaques in atherosclerotic patients...
  29. ncbi request reprint Vascular smooth muscle cell proliferation is dependent upon upregulation of mitochondrial transcription factor A (mtTFA) expression in injured rat carotid artery
    Tomonori Yoshida
    Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Medicine, 3 18 15 Kuramoto cho, Tokushima 770 8503, Japan
    Atherosclerosis 178:39-47. 2005
    ..These data demonstrate that expression of mtTFA is upregulated in intimal VSMC of injured rat carotid artery, and that suppression of mtTFA expression by antisense ODN can attenuate intimal thickening after balloon injury...
  30. doi request reprint Androgen-androgen receptor system protects against angiotensin II-induced vascular remodeling
    Yasumasa Ikeda
    Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Health Biosciences, Tokushima, Japan
    Endocrinology 150:2857-64. 2009
    ....
  31. doi request reprint Inhibition of thrombin action ameliorates insulin resistance in type 2 diabetic db/db mice
    Masatomo Mihara
    Department of Medicine and Bioregulatory Sciences, The University of Tokushima Graduate School of Medical Sciences, 3 18 15 Kuramoto cho, Tokushima 770 8503, Japan
    Endocrinology 151:513-9. 2010
    ....
  32. ncbi request reprint Aspirin inhibits thrombin action on endothelial cells via up-regulation of aminopeptidase N/CD13 expression
    Midori Kato
    Department of Medicine and Bioregulatory Sciences, Institute of Health Biosciences, The University of Tokushima Graduate School, 3 18 15 Kuramoto cho, Tokushima 770 8503, Japan
    Atherosclerosis 183:49-55. 2005
    ..We hypothesized that aspirin may exhibit its anti-atherosclerotic effects via mechanisms other than cyclooxygenase inhibition in platelets...
  33. doi request reprint Deferoxamine promotes angiogenesis via the activation of vascular endothelial cell function
    Yasumasa Ikeda
    Department of Pharmacology, University of Tokushima Graduate School of Health Biosciences, 3 18 15 Kuramoto cho, Tokushima 770 8503, Japan
    Atherosclerosis 215:339-47. 2011
    ..Herein, we clarify the effect and mechanism of action of DFO on angiogenesis...
  34. ncbi request reprint Effect of aspirin treatment on serum concentrations of lipoprotein(a) in patients with atherosclerotic diseases
    Masashi Akaike
    Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Medicine, 3 18 15 Kuramoto cho, Tokushima 770 8503, Japan
    Clin Chem 48:1454-9. 2002
    ..We previously reported that aspirin reduced Lp(a) production by cultured hepatocytes via the reduction of apolipoprotein(a) [apo(a)] gene transcription...
  35. pmc Transforming Growth Factor-β1 as a Common Target Molecule for Development of Cardiovascular Diseases, Renal Insufficiency and Metabolic Syndrome
    Ken ichi Aihara
    Department of Medicine and Bioregulatory Sciences, The University of Tokushima, Graduate School of Health Biosciences, 3 18 15 Kuramoto cho, Tokushima 770 8503, Japan
    Cardiol Res Pract 2011:175381. 2010
    ....
  36. doi request reprint Role of hypoxia-inducible factor 1alpha in T cells as a negative regulator in development of vascular remodeling
    Hirotsugu Kurobe
    epartment of Cardiovascular Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    Arterioscler Thromb Vasc Biol 30:210-7. 2010
    ..We show that hypoxia-inducible factor 1 (Hif-1) (specifically expressed in T cells) is involved in the immune response to vascular remodeling that accompanies arteriosclerosis...
  37. ncbi request reprint Improvement of cardiac diastolic function and prognosis after autologous peripheral blood stem cell transplantation in AL cardiac amyloidosis
    Shusuke Yagi
    Department of Medicine and Bioregulatory Sciences, Institute of Health Biosciences, The University of Tokushima Graduate School
    Intern Med 46:1705-10. 2007
    ..This treatment resulted in significant improvement in cardiac function and good prognosis for about 3.5 years after the diagnosis. Therefore, auto-PBSCT is a possible option as up-front therapy for AL cardiac amyloidosis...
  38. ncbi request reprint Congenital ventricular aneurysm as an unexpected complication of monomorphic premature ventricular contractions
    Shusuke Yagi
    Department of Cardiovascular Medicine, The University of Tokushima Graduate School of Health Biosciences
    Intern Med 49:907-12. 2010
    ..Here, we report two successfully followed cases of CVA which were diagnosed from premature ventricular contractions...
  39. ncbi request reprint Bosentan ameliorated exercise-induced pulmonary arterial hypertension complicated with systemic sclerosis
    Shusuke Yagi
    Department of Cardiovascular Medicine, The University of Tokushima Graduate School of Health Biosciences, Tokushima
    Intern Med 49:2309-12. 2010
    ..The results suggest that administration of bosentan in patients with early-stage PAH ameliorates pulmonary arterial vasodilatation through improvement of endothelial function...
  40. doi request reprint Carbohydrate-to-insulin ratio is estimated from 300-400 divided by total daily insulin dose in type 1 diabetes patients who use the insulin pump
    Akio Kuroda
    Diabetes Therapeutics and Research Center, The University of Tokushima, Tokushima, Japan
    Diabetes Technol Ther 14:1077-80. 2012
    ..We recently reported that basal insulin requirement is approximately 30% of TDD. We therefore investigated CIR after adjustment of the proper basal insulin rate...