A Tanaka

Summary

Affiliation: Teikyo University
Country: Japan

Publications

  1. ncbi request reprint Expression of Aurora-B kinase and phosphorylated histone H3 in hepatocellular carcinoma
    Anchalee Sistayanarain
    Molecular and Pathology, School of Medicine, University of Toyama, Sugitani 2630, Toyama, Japan
    Anticancer Res 26:3585-93. 2006
  2. doi request reprint Outcome and prognostic factors of 391 Japanese patients with primary sclerosing cholangitis
    Atsushi Tanaka
    Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan
    Liver Int 28:983-9. 2008
  3. doi request reprint Vitamin D receptor polymorphisms are associated with increased susceptibility to primary biliary cirrhosis in Japanese and Italian populations
    Atsushi Tanaka
    Department of Medicine, Teikyo University School of Medicine, 2 11 1, Kaga, Itabashi ku, Tokyo 173 8605, Japan
    J Hepatol 50:1202-9. 2009
  4. ncbi request reprint Hepatic steatosis as a possible risk factor for the development of hepatocellular carcinoma after eradication of hepatitis C virus with antiviral therapy in patients with chronic hepatitis C
    Atsushi Tanaka
    Department of Medicine, Teikyo University School of Medicine, 2 11 1, Kaga, Tokyo, Japan
    World J Gastroenterol 13:5180-7. 2007
  5. ncbi request reprint The clinical significance of IgA antimitochondrial antibodies in sera and saliva in primary biliary cirrhosis
    Atsushi Tanaka
    Department of Medicine, Teikyo University School of Medicine, 2 11 1, Kaga, Itabashi ku, Tokyo 173 8605, Japan
    Ann N Y Acad Sci 1107:259-70. 2007
  6. doi request reprint Genetic association of Fc receptor-like 3 polymorphisms with susceptibility to primary biliary cirrhosis: ethnic comparative study in Japanese and Italian patients
    A Tanaka
    Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan
    Tissue Antigens 77:239-43. 2011
  7. doi request reprint Replicated association of 17q12-21 with susceptibility of primary biliary cirrhosis in a Japanese cohort
    A Tanaka
    Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan
    Tissue Antigens 78:65-8. 2011
  8. ncbi request reprint Gene expression profiling in whole liver of bile duct ligated rats: VEGF-A expression is up-regulated in hepatocytes adjacent to the portal tracts
    Atsushi Tanaka
    Department of Medicine, School of Medicine, Teikyo University, Tokyo, Japan
    J Gastroenterol Hepatol 22:1993-2000. 2007
  9. ncbi request reprint Inhibitory effects of suplatast tosilate on the differentiation and function of monocyte-derived dendritic cells from patients with asthma
    A Tanaka
    First Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan
    Clin Exp Allergy 37:1083-9. 2007
  10. ncbi request reprint Use of synchrotron radiation microangiography to assess development of small collateral arteries in a rat model of hindlimb ischemia
    S Takeshita
    Second Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan
    Circulation 95:805-8. 1997

Collaborators

Detail Information

Publications71

  1. ncbi request reprint Expression of Aurora-B kinase and phosphorylated histone H3 in hepatocellular carcinoma
    Anchalee Sistayanarain
    Molecular and Pathology, School of Medicine, University of Toyama, Sugitani 2630, Toyama, Japan
    Anticancer Res 26:3585-93. 2006
    ..This study aimed at investigating the expression of Aurora-B kinase (Aurora-B) and phosphorylated histone H3 (H3-P) and their roles in hepatocellular carcinogenesis...
  2. doi request reprint Outcome and prognostic factors of 391 Japanese patients with primary sclerosing cholangitis
    Atsushi Tanaka
    Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan
    Liver Int 28:983-9. 2008
    ..We performed a national survey in 2003, and demonstrated characteristic features of primary sclerosing cholangitis (PSC) patients in Japan. In this study, we aimed to clarify the outcome and prognostic factors of Japanese PSC patients...
  3. doi request reprint Vitamin D receptor polymorphisms are associated with increased susceptibility to primary biliary cirrhosis in Japanese and Italian populations
    Atsushi Tanaka
    Department of Medicine, Teikyo University School of Medicine, 2 11 1, Kaga, Itabashi ku, Tokyo 173 8605, Japan
    J Hepatol 50:1202-9. 2009
    ..In the current study, we aimed at elucidating the genetic association of VDR polymorphisms with susceptibility to PBC in Japanese and Italian populations...
  4. ncbi request reprint Hepatic steatosis as a possible risk factor for the development of hepatocellular carcinoma after eradication of hepatitis C virus with antiviral therapy in patients with chronic hepatitis C
    Atsushi Tanaka
    Department of Medicine, Teikyo University School of Medicine, 2 11 1, Kaga, Tokyo, Japan
    World J Gastroenterol 13:5180-7. 2007
    ....
  5. ncbi request reprint The clinical significance of IgA antimitochondrial antibodies in sera and saliva in primary biliary cirrhosis
    Atsushi Tanaka
    Department of Medicine, Teikyo University School of Medicine, 2 11 1, Kaga, Itabashi ku, Tokyo 173 8605, Japan
    Ann N Y Acad Sci 1107:259-70. 2007
    ....
  6. doi request reprint Genetic association of Fc receptor-like 3 polymorphisms with susceptibility to primary biliary cirrhosis: ethnic comparative study in Japanese and Italian patients
    A Tanaka
    Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan
    Tissue Antigens 77:239-43. 2011
    ..We found a significant association of fcrl3_3 with PBC only in Japanese (P = 9.64 √ó 10(-7) ). These findings support the presence of common FCRL3-related pathological pathways in several autoimmune diseases, especially in Asians...
  7. doi request reprint Replicated association of 17q12-21 with susceptibility of primary biliary cirrhosis in a Japanese cohort
    A Tanaka
    Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan
    Tissue Antigens 78:65-8. 2011
    ..0024, P(c) = 0.017) after correction for multiple comparisons. Thus, these results indicate a haplotype on 17q12-21 with a similar association in Japanese and European PBC...
  8. ncbi request reprint Gene expression profiling in whole liver of bile duct ligated rats: VEGF-A expression is up-regulated in hepatocytes adjacent to the portal tracts
    Atsushi Tanaka
    Department of Medicine, School of Medicine, Teikyo University, Tokyo, Japan
    J Gastroenterol Hepatol 22:1993-2000. 2007
    ..In addition, the localization and time course of up-regulated expression of vascular endothelial growth factor (VEGF) was investigated...
  9. ncbi request reprint Inhibitory effects of suplatast tosilate on the differentiation and function of monocyte-derived dendritic cells from patients with asthma
    A Tanaka
    First Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan
    Clin Exp Allergy 37:1083-9. 2007
    ..Dendritic cells (DCs) are antigen-presenting cells that efficiently activate T cells...
  10. ncbi request reprint Use of synchrotron radiation microangiography to assess development of small collateral arteries in a rat model of hindlimb ischemia
    S Takeshita
    Second Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan
    Circulation 95:805-8. 1997
    ..In the present study, we applied this microangiography system to visualize small arteries in normal and ischemic rat limbs and investigated the development of collateral arteries...
  11. ncbi request reprint Inhibitory effects of fluvastatin on cytokine and chemokine production by peripheral blood mononuclear cells in patients with allergic asthma
    K T R Samson
    First Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan
    Clin Exp Allergy 36:475-82. 2006
    ..Statins have anti-inflammatory effects on immune cells...
  12. doi request reprint Effect of tiotropium bromide on airway inflammation and remodelling in a mouse model of asthma
    S Ohta
    Department of Internal Medicine, Division of Allergy and Respiratory Medicine, School of Medicine, Showa University, Tokyo, Japan
    Clin Exp Allergy 40:1266-75. 2010
    ..Tiotropium bromide, a long acting muscarinic receptor inhibitor, is a potent agent for patients with bronchial asthma as well as chronic obstructive pulmonary disease...
  13. ncbi request reprint Potential role of recombinant annexin II in diabetic vascular injury
    H Ishii
    Department of Medicine, School of Medicine, Tokyo Medical and Dental University, Japan
    Ann N Y Acad Sci 947:308-11. 2001
    ..In this review, we overviewed the effect of glucose and insulin on plasmin generation in endothelial cells and its potential modulation by recombinant annexin II (rAN II) based on our data...
  14. ncbi request reprint Detection of antimitochondrial autoantibodies in immunofluorescent AMA-negative patients with primary biliary cirrhosis using recombinant autoantigens
    H Miyakawa
    Fourth Department of Internal Medicine, Teikyo University School of Medicine, Kanagawa, Japan
    Hepatology 34:243-8. 2001
    ....
  15. ncbi request reprint Underglycosylation of IgA1 hinge plays a certain role for its glomerular deposition in IgA nephropathy
    Y Hiki
    Department of Medicine, School of Nursing and Medicine, Kitasato University, Sagamihara, Japan
    J Am Soc Nephrol 10:760-9. 1999
    ..These results indicated that the IgA1 molecules having the underglycosylated hinge glycopeptide played a certain role in the glomerular accumulation of IgA1 in IgA nephropathy...
  16. ncbi request reprint Relationship between plasma insulin concentration and plasma remnant lipoprotein response to an oral fat load in patients with type 2 diabetes
    M Ai
    Third Department of Internal Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    J Am Coll Cardiol 38:1628-32. 2001
    ..CONCLUSIONS: Remnant lipoprotein response to an oral fat load is significantly increased in hyperinsulinemic patients with type 2 diabetes. These changes may increase the risk of coronary heart disease in these individuals...
  17. doi request reprint Antifungal effects of palmitic acid salt and ultrapure soft water on Scedosporium apiospermum
    K Jung
    Laboratory of Comparative Animal Medicine, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology, Fuchu, Tokyo, Japan
    J Appl Microbiol 115:711-7. 2013
    ..Scedosporium apiospermum sometimes causes serious infectious diseases on the skin of immunodeficient subjects. Antifungal effects of fatty acid salts in soap against S. apiospermum were investigated under different water conditions...
  18. ncbi request reprint Single nucleotide polymorphisms of the mannose-binding lectin are associated with susceptibility to primary biliary cirrhosis
    M Matsushita
    Fourth Department of Internal Medicine, Teikyo University School of Medicine, Kanagawa 213 8507, Japan
    J Autoimmun 17:251-7. 2001
    ..34-4.66). Our results demonstrate that the MBL genotype can be significantly associated with increased risk for PBC, and further, that increased production of MBL plays a critical role in immunopathogenesis...
  19. ncbi request reprint Effect of dilazep dihydrochloride on urinary albumin excretion in patients with autosomal dominant polycystic kidney disease
    T Nakamura
    Department of Medicine, Misato Junshin Hospital, Misato, Japan
    Nephron 88:80-2. 2001
    ..There was no reduction in group C. There were no changes in UAE in placebo groups B and D. These results suggest that dilazep dihydrochloride may be effective in reducing UAE in normotensive ADPKD patients with microalbuminuria...
  20. doi request reprint Heterogeneity of internal tandem duplications in the c-kit of dogs with multiple mast cell tumours
    Y Amagai
    Cooperative Major in Advanced Health Science, Graduate School of Bio Applications and System Engineering, Tokyo University of Agriculture and Technology, Tokyo, Japan
    J Small Anim Pract 54:377-80. 2013
    ..It is proposed that, for clinicians, genetic analysis of several regions of multiple mast cell tumours is necessary for predicting prognosis and tumour response to KIT inhibitors. ..
  21. ncbi request reprint Association between lipid peroxidation and inflammation in obstructive sleep apnoea
    K Minoguchi
    First Dept of Internal Medicine, Showa University, School of Medicine, 1 5 8 Hatanodai, Tokyo 142 8666, Japan
    Eur Respir J 28:378-85. 2006
    ..Therefore, obstructive sleep apnoea may increase the risks of cardiovascular morbidity in obese patients...
  22. ncbi request reprint Genetic and familial considerations of primary biliary cirrhosis
    A Tanaka
    The Institute for Adult Diseases, Asahi Life Foundation, Tokyo, Japan
    Am J Gastroenterol 96:8-15. 2001
    ..In this review, we place these concepts in perspective and highlight in particular the genetic associations in PBC and the importance of studying siblings with PBC who are concordant for disease...
  23. ncbi request reprint Association of single nucleotide polymorphisms of the interleukin-10 promoter gene and susceptibility to primary biliary cirrhosis: immunogenetic differences in Italian and Japanese patients
    Masanao Matsushita
    Fourth Department of Internal Medicine, Teikyo University School of Medicine, Kanagawa 213 8507, Japan
    Autoimmunity 35:531-6. 2002
    ..Further, immunogenetic studies of PBC should take into account ethnic and geographic variations; this makes such studies in heterogeneous population, like the USA, more difficult...
  24. doi request reprint Stem cell factor contributes to tumorigenesis of mast cells via an autocrine/paracrine mechanism
    Y Amagai
    Cooperative Major in Advanced Health Science, Graduate School of Bio Applications and System Engineering, Tokyo University of Agriculture and Technology, Tokyo, Japan
    J Leukoc Biol 93:245-50. 2013
    ..These results indicate the possibility that targeting SCF production may become a novel treatment for mast cell malignancies...
  25. ncbi request reprint A case of autoimmune hepatitis with a high titer of antimitochondrial antibody and normal gamma-globulinemia
    M Shibata
    Second Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan
    J Gastroenterol Hepatol 16:830-5. 2001
    ..In contrast, she responded completely to corticosteroid therapy. The clinical course and histological findings of this patient strongly suggest that this patient has autoimmune hepatitis...
  26. ncbi request reprint Increased endothelin: nitric oxide ratio is associated with erythropoietin-induced hypertension in hemodialysis patients
    N Shimada
    Division of Nephrology and Hypertension, Department of Medicine, Koto Hospital, Tokyo, Japan
    Ren Fail 25:569-78. 2003
    ..These results suggest that an increase in ET-1/NOx ratio in blood, probably occurring in vascular endothelial cells, may be associated with rHuEPO-induced hypertension in HD patients...
  27. doi request reprint Regulatory challenges in the review of data from global clinical trials: the PMDA perspective
    K Asano
    Pharmaceuticals and Medical Devices Agency PMDA, Tokyo, Japan
    Clin Pharmacol Ther 94:195-8. 2013
    ..Here, we present the Pharmaceuticals and Medical Devices Agency (PMDA) perspective in reviewing GCT data in new drug applications (NDAs) and discuss future challenges for new drug approval. ..
  28. doi request reprint Relationship between pattern of masticatory path and state of lateral occlusal contact
    H Shiga
    Department of Partial and Complete Denture, School of Life Dentistry at Tokyo, The Nippon Dental University, Tokyo, Japan
    J Oral Rehabil 36:250-6. 2009
    ..001, L3; P = 0.030) but not at L1 (P = 0.318). The difference was remarkable at L2. It was suggested that the state of occlusal contact at L2 and L3, particularly at L2 was related to the masticatory path pattern...
  29. ncbi request reprint Stimulation of arterial smooth muscle cell proliferation by remnant lipoprotein particles isolated by immuno-affinity chromatography with anti-apo A-I and anti-apo B-100
    A Kawakami
    Third Department of Internal Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Horm Metab Res 33:67-72. 2001
    ..006) was virtually ineffective. These observations are consistent with recent reports that triglyceride-rich lipoprotein remnants, which are rich in apo E as well, are atherogenic...
  30. ncbi request reprint Triglyceride-rich lipoprotein cholesterol exceeds low-density lipoprotein cholesterol in hypertriglyceridemia patients
    M Ai
    Third Department of Internal Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Horm Metab Res 33:612-7. 2001
    ..Our study suggests that hypertriglyceridemia should be treated to prevent arteriosclerotic disease...
  31. ncbi request reprint Recombinant annexin II modulates impaired fibrinolytic activity in vitro and in rat carotid artery
    H Ishii
    Department of Medicine, School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Circ Res 89:1240-5. 2001
    ..Further study of rAN II in vitro and in vivo may lead to the establishment of novel therapeutic approaches to thrombogenic vascular disease...
  32. ncbi request reprint Microangiographic assessment of collateral vessel formation following direct gene transfer of vascular endothelial growth factor in rats
    S Takeshita
    Department of Medicine Cardiology, Teikyo University School of Medicine, Tokyo, Japan
    Cardiovasc Res 35:547-52. 1997
    ....
  33. ncbi request reprint Expression of matrix metalloproteinase-2 and -9 in synovial fluid of the temporomandibular joint accompanied by anterior disc displacement
    A Tanaka
    Department of Oral and Maxillofacial Surgery, School of Medicine, Kanazawa University, Kanazawa City, Ishikawa, Japan
    J Oral Pathol Med 30:59-64. 2001
    ..These data suggest that the presence or absence of disc reduction is a major turning point in the process of joint destruction, and these MMPs are useful as biochemical markers for TMD diagnosis...
  34. ncbi request reprint Genetic polymorphisms of transforming growth factor beta-1 promoter and primary biliary cirrhosis in Japanese patients
    Kentaro Kikuchi
    Fourth Department of Internal Medicine, Teikyo University School of Medicine, Kanagawa 213 8507, Japan
    Ann N Y Acad Sci 1110:15-22. 2007
    ..In conclusion, the TGF-beta1 promoter gene SNPs are not associated with disease susceptibility or progression in Japanese patients with PBC...
  35. doi request reprint Congenital insensitivity to pain with anhidrosis: a case with preserved itch sensation to histamine and partial pain sensation
    T Tanaka
    Department of Dermatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Br J Dermatol 166:888-91. 2012
    ..These findings suggest that there was a partial preservation of the nerve endings that express the H(1) receptor and/or TRPV1 in the upper dermis, even though there were mutations of the NTRK1 gene in this case...
  36. ncbi request reprint Prediction of endocrine disruptors based on a new structure-activity relationship for sex and environmental hormones using chemical hardness concept
    S Kobayashi
    Department of Analytical Chemistry of Medicines, Showa Pharmaceutical University, Machida, Tokyo, Japan
    Chem Pharm Bull (Tokyo) 49:680-8. 2001
    ..The eta-chi activity diagram is a new tool for the prediction of the toxicity and biological activity of environmental hormones...
  37. ncbi request reprint Ingestion of heat-treated Lactobacillus rhamnosus GG prevents development of atopic dermatitis in NC/Nga mice
    J Sawada
    Laboratory of Veterinary Molecular Pathology and Therapeutics, Division of Animal Life Science, Graduate School, Institute of Symbiotic Science and Technology, Tokyo University of Agriculture and Technology, Tokyo, Japan
    Clin Exp Allergy 37:296-303. 2007
    ..GG) to pregnant subjects with atopic dermatitis and their children, suppressed the frequency of atopic dermatitis. The details of mechanisms and immune systems involved in this suppressive effect, however, remain speculative...
  38. ncbi request reprint A support film of plasma-polymerized naphthalene for electron microscopy: method of preparation and application
    M Yamaguchi
    Department of Morphology, Institute of Medical Science, Jikei University School of Medicine, Tokyo, Japan
    J Electron Microsc (Tokyo) 41:7-13. 1992
    ..The PNS would be useful for both routine and high-resolution electron microscopy...
  39. ncbi request reprint Exposure to hardly soluble indium compounds in ITO production and recycling plants is a new risk for interstitial lung damage
    T Hamaguchi
    Department of Preventive Medicine and Public Health, School of Medicine, Keio University Tokyo, Japan
    Occup Environ Med 65:51-5. 2008
    ..To identify the effects of indium on the lung and to assess exposure-effect and exposure-response relations between indium exposure and effects on the lungs...
  40. ncbi request reprint Western blotting analysis of the beta-hexosaminidase alpha- and beta-subunits in cultured fibroblasts from cases of various forms of GM2 gangliosidosis
    K Utsumi
    The Second Department of Internal Medicine, Nippon Medical School, Bunkyo ku, Tokyo, Japan
    Acta Neurol Scand 105:427-30. 2002
    ..We examined the alpha- and beta-subunits of beta-hexosaminidases by a non-radioisotopes detecting system to evaluate whether it was a useful method for understanding of the pathophysiologies of GM2 gangliosidoses...
  41. ncbi request reprint Hair analysis for drugs of abuse. XVII. Simultaneous detection of PCP, PCHP, and PCPdiol in human hair for confirmation of PCP use
    Y Nakahara
    National Institute of Health Sciences, Tokyo, Japan
    J Anal Toxicol 21:356-62. 1997
    ..12 ng/mg, and trans-PCPdiol between 0.09 and 0.45 ng/mg. It was found that t-PCPdiol was the major metabolite in the PCP users' hair specimens, although t-PCPdiol was a minor metabolite in the hair specimens of rats intoxicated with PCP...
  42. ncbi request reprint A double-blind trial on the effects of atorvastatin on glycemic control in Japanese diabetic patients with hypercholesterolemia
    A Tanaka
    Third Department of Internal Medicine, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, 113 8519, Tokyo, Japan
    Clin Chim Acta 312:41-7. 2001
    ..These findings are clinically important because there are many diabetic patients with hypercholesterolemia and such patients have a high risk of developing arteriosclerotic disease...
  43. ncbi request reprint Regulation of erythrocyte ghost membrane mechanical stability by chlorpromazine
    A Enomoto
    Department of Psychiatry, Tokyo Women's Medical University, Tokyo, Japan
    Biochim Biophys Acta 1512:285-90. 2001
    ..Membrane active drugs that partition into lipid bilayer can thus induce cytoskeletal protein interactions with the membrane and modulate membrane material properties...
  44. ncbi request reprint DNA topology on an increase in positive writhing number of DNA: conformation changes in the time course of cis-diamminedichloroplatinum(II)-DNA adducts
    S Kobayashi
    Department of Analytical Chemistry of Medicines, Showa Pharmaceutical University, Machida, Tokyo, Japan
    Chem Pharm Bull (Tokyo) 49:1053-60. 2001
    ..To explain the abstraction of Pt ion, we also discuss the findings based on the thermodynamic cycle in a intermolecular crosslink model Pt(NH3)2(guanine)2(2+)-->Pt(CN)4(2-) using the Pt parametrized PM3 method...
  45. pmc K-ras mutations and cell kinetics in Helicobacter pylori associated gastric intestinal metaplasia: a comparison before and after eradication in patients with chronic gastritis and gastric cancer
    J Watari
    Division of Gastroenterology and Hepatology, Department of Medicine, Asahikawa Medical College, Asahikawa, Japan
    J Clin Pathol 60:921-6. 2007
    ..Helicobacter pylori related gastric intestinal metaplasia (IM) is considered to be a precancerous lesion...
  46. ncbi request reprint Suplatast tosilate inhibits thymus- and activation-regulated chemokine production by antigen-specific human Th2 cells
    N Oda
    First Department of Internal Medicine, Showa University, Tokyo, Japan
    Clin Exp Allergy 32:1782-6. 2002
    ..Suplatast tosilate is an anti-allergic agent that suppresses cytokine production by human Th2 cells...
  47. ncbi request reprint Haemopoietic biglycan produced by brain cells stimulates growth of microglial cells
    A Kikuchi
    National Institute of Neuroscience, NCNP, 4 1 1 Ogawahigashi cho, Kodaira, Tokyo, Japan
    J Neuroimmunol 106:78-86. 2000
    ..Taken together, these results suggest that the haemopoietic biglycan plays an important role in generating brain-specific circumstances for development of microglial/monocytic cells...
  48. pmc Serum reactivity against bacterial pyruvate dehydrogenase: increasing the specificity of anti-mitochondrial antibodies for the diagnosis of primary biliary cirrhosis
    Hiroshi Miyakawa
    Fourth Department of Internal Medicine, Teikyo University School of Medicine, Kanagawa 213 8507, Japan
    Clin Dev Immunol 13:289-94. 2006
    ..The use of a specific buffer might avoid the risk of false positive AMA determinations when E. coli-expressed recombinant antigens are used...
  49. ncbi request reprint Presence of antimitochondrial autoantibodies in patients with autoimmune hepatitis
    Saeko Nezu
    Third Department of Internal Medicine, School of Medicine, Kyorin University, Tokyo, Japan
    J Gastroenterol Hepatol 21:1448-54. 2006
    ..The aim of the present study was to determine whether the presence of AMA is associated with clinical features, especially the occurrence of bile duct lesions, in patients with AIH...
  50. ncbi request reprint The diagnostic value of anti-mitochondrial antibodies, especially in primary biliary cirrhosis
    Atsushi Tanaka
    The Institute for Adult Diseases, Asahi Life Foundation, Tokyo, Japan
    Cell Mol Biol (Noisy-le-grand) 48:295-9. 2002
    ..The choice of therapeutic regimen should, therefore, be based on a combination of serological, biochemical and histological findings, rather than AMA status alone...
  51. ncbi request reprint Successful treatment with colestimide for a bout of cholestasis in a Japanese patient with benign recurrent intrahepatic cholestasis caused by ATP8B1 mutation
    Satoko Uegaki
    Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan
    Intern Med 47:599-602. 2008
    ....
  52. ncbi request reprint Detection of autoantibody against carbonic anhydrase II in various liver diseases by enzyme-linked immunosorbent assay using appropriate conditions
    Hideo Hosoda
    Division of Clinical Laboratory Medicine, Tokyo Kosei Nenkin Hospital, Shinjuku, Tokyo, Japan
    Clin Chim Acta 342:71-81. 2004
    ..Moreover, we also found that a small amount of an IgG-like material exists in purchased CAII reagents, which causes pseudopositive reactions...
  53. ncbi request reprint Size distributions of soil particles adhered to children's hands
    Naomichi Yamamoto
    Department of Environmental System, Institute of Environmental Studies, Graduate School of Frontier Sciences, University of Tokyo, Hongo 7 3 1, Tokyo, 113 8656, Japan
    Arch Environ Contam Toxicol 51:157-63. 2006
    ....
  54. ncbi request reprint Human T-cell leukaemia virus type I is highly sensitive to UV-C light
    Akira Shimizu
    Department of Virology and Preventive Medicine, Gunma University Graduate School of Medicine, 3 39 22 Showa machi, Maebashi, Gunma 371 8511, Japan
    J Gen Virol 85:2397-406. 2004
    ..HTLV-I was found to be much more sensitive than other retroviruses to UV...
  55. ncbi request reprint A gene homologous to human endogenous retrovirus overexpressed in childhood acute lymphoblastic leukemia
    Haruko Iwabuchi
    Division of Pediatrics, Department of Homeostatic Regulation and Development, Niigata, University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Leuk Lymphoma 45:2303-6. 2004
    ..These findings indicate that the gene may play a role in leukemogenesis and may be a novel leukemia marker. Further studies on the functional role of the gene are needed...
  56. ncbi request reprint Congenital Rosai-Dorfman disease without lymphadenopathy
    Haruko Iwabuchi
    Division of Pediatrics, Department of Homeostatic Regulation and Development, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi Dori 1, Niigata, 951 8510, Japan
    Pediatr Pathol Mol Med 22:399-403. 2003
    ..This case is thought to be congenital RDD without lymphadenopathy...
  57. pmc Serial analysis of antimitochondrial antibody in patients with primary biliary cirrhosis
    Gordon D Benson
    Department of Medicine, UMDNJ Robert Wood Johnson Medical School, 401 Haddon Avenue, Camden, NJ 08103, USA
    Clin Dev Immunol 11:129-33. 2004
    ..Furthermore, despite this long follow-up, there was no evidence for a significant change in AMA levels; also, levels were not influenced by drug therapy used during the period of observation...
  58. pmc Formation of vesicular stomatitis virus pseudotypes bearing surface proteins of hepatitis B virus
    Manujendra N Saha
    Department of Virology and Preventive Medicine, Gunma University Graduate School of Medicine, Showa machi, Maebashi, Gunma 371 8511, Japan
    J Virol 79:12566-74. 2005
    ..Pretreatment of the cells with trypsin or tunicamycin inhibited plating of the pseudotype samples. The HBV pseudotypes can be used to analyze early steps of HBV infection, including the entry mechanism of HBV...
  59. ncbi request reprint Efficient formation of vesicular stomatitis virus pseudotypes bearing the native forms of hepatitis C virus envelope proteins detected after sonication
    Kazushi Tamura
    Department of Virology and Preventive Medicine, Gunma University Graduate School of Medicine, 3 39 22 Showa machi, Maebashi, Gunma 371 8511, Japan
    Microbes Infect 7:29-40. 2005
    ..The VSV pseudotypes developed here would be useful for analyzing the early stages of HCV infection...
  60. ncbi request reprint Molecular mimicry of mitochondrial and nuclear autoantigens in primary biliary cirrhosis
    Shinji Shimoda
    Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Gastroenterology 124:1915-25. 2003
    ..Virtually all patients with PBC have antimitochondrial autoantibodies (AMA), but, interestingly, approximately 50% also manifest antinuclear antibodies (ANA)...
  61. ncbi request reprint Peroxisome division is impaired in a CHO cell mutant with an inactivating point-mutation in dynamin-like protein 1 gene
    Atsushi Tanaka
    Department of Biology, Faculty of Sciences, Kyushu University Graduate School, Fukuoka 812 8581, Japan
    Exp Cell Res 312:1671-84. 2006
    ..Furthermore, ZP121 was lowered in the level of phospholipids, plasmalogens, and phosphatidylethanolamine and was less sensitive to oxidative stresses. Thus, ZP121 is the first dlp1 mutant in mammalian cells...
  62. ncbi request reprint Fis1, DLP1, and Pex11p coordinately regulate peroxisome morphogenesis
    Shinta Kobayashi
    Graduate School of Systems Life Sciences, Kyushu University, Fukuoka 812 8581, Japan
    Exp Cell Res 313:1675-86. 2007
    ..Taken together, these findings indicate that Fis1 plays important roles in peroxisome division and maintenance of peroxisome morphology in mammalian cells, possibly in a concerted manner with Pex11pbeta and DLP1...
  63. ncbi request reprint cDNA cloning and characterization of the third isoform of human peroxin Pex11p
    Atsushi Tanaka
    Department of Biology, Faculty of Sciences, Kyushu University Graduate School, 6 10 1 Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    Biochem Biophys Res Commun 300:819-23. 2003
    ..PEX11gamma was not induced in rats by treatment of clofibrate, a peroxisome proliferator, similar to constitutively expressed PEX11beta but in contrast to inducible PEX11alpha...
  64. ncbi request reprint Primary hepatic somatostatinoma developed in a patient with von Recklinghausen's disease
    Yoshihiko Morisawa
    J Gastroenterol 41:389-91. 2006
  65. pmc Antimitochondrial antibodies in acute liver failure: implications for primary biliary cirrhosis
    Patrick S C Leung
    Division of Rheumatology Allergy, University of California, Davis Medical Center, Sacramento, CA, USA
    Hepatology 46:1436-42. 2007
    ..The rapid disappearance of AMAs in these patients provides further support for the contention that PBC pathogenesis requires additional factors, including genetic susceptibility...
  66. ncbi request reprint C-reactive protein and lesion morphology in patients with acute myocardial infarction
    Toshihiko Sano
    Baba Memorial Hospital, Sakai, Japan
    Circulation 108:282-5. 2003
    ..In this study, we investigated the relation between lesion morphology as seen under preintervention intravascular ultrasound (IVUS) and CRP in the acute phase of AMI...
  67. ncbi request reprint Liver-targeted and peripheral blood alterations of regulatory T cells in primary biliary cirrhosis
    Ruth Y Lan
    Division of Rheumatology, Allergy, and Clinical Immunology, University of California Davis, Davis, CA 95616, USA
    Hepatology 43:729-37. 2006
    ..001) and early-stage AIH (P < .001). In conclusion, these data provide support for a genetic modulation of Treg frequency and illustrate the role Tregs play in the loss of tolerance in PBC...
  68. pmc Genome-wide expression of azoospermia testes demonstrates a specific profile and implicates ART3 in genetic susceptibility
    Hiroyuki Okada
    Department of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    PLoS Genet 4:e26. 2008
    ..These findings clarify the molecular pathophysiology of NOA and suggest a novel therapeutic target in the treatment of NOA...
  69. doi request reprint A chemical inhibitor of DRP1 uncouples mitochondrial fission and apoptosis
    Atsushi Tanaka
    Biochemistry Section, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20824, USA
    Mol Cell 29:409-10. 2008
    ..In a recent issue of Developmental Cell, Cassidy-Stone et al. (2008) identified mdivi-1, a new DRP1 inhibitor that prevents mitochondria division and Bax-mediated mitochondrial outer membrane permeabilization during apoptosis...
  70. ncbi request reprint Severe steatosis resulted from anorexia nervosa leading to fatal hepatic failure
    Michinori Sakada
    J Gastroenterol 41:714-5. 2006
  71. ncbi request reprint Hepatocellular injuries observed in patients with an eating disorder prior to nutritional treatment
    Masayo Tsukamoto
    Department of Internal Medicine, St Luke s International Hospital, Tokyo
    Intern Med 47:1447-50. 2008
    ..In this retrospective study, we aimed to reveal the characteristics of hepatocellular injuries in patients with an eating disorder without any nutritional treatment, to eliminate the possible hepatotoxic effects of nutritional support...