T Nakaki

Summary

Affiliation: Teikyo University
Country: Japan

Publications

  1. pmc CK2 as anti-stress factor
    Masahiko Watabe
    Department of Pharmacology Teikyo University School of Medicine Tokyo, Japan
    Commun Integr Biol 5:278-80. 2012
  2. pmc Impaired glutathione synthesis in neurodegeneration
    Koji Aoyama
    Department of Pharmacology, Teikyo University School of Medicine, 2 11 1 Kaga, Itabashi, Tokyo 173 8605, Japan
    Int J Mol Sci 14:21021-44. 2013
  3. ncbi request reprint Learning adverse drug effects from judicial precedents
    Toshio Nakaki
    Department of Pharmacology, Teikyo University School of Medicine, 2 11 1 Kaga, Itabashi Ward, Tokyo 173 8605, Japan
    Naunyn Schmiedebergs Arch Pharmacol 366:30-2. 2002
  4. ncbi request reprint [The arginine paradox]
    Toshio Nakaki
    Department of Pharmacology, Teikyo University School of Medicine, 2 11 1 Kaga, Itabashi ku, Tokyo 173 8605, Japan
    Nihon Yakurigaku Zasshi 119:7-14. 2002
  5. ncbi request reprint Glufosinate ammonium stimulates nitric oxide production through N-methyl D-aspartate receptors in rat cerebellum
    T Nakaki
    Department of Pharmacology, Teikyo University School of Medicine, 2 11 1 Kaga, Itabashi ku, 173 8605, Tokyo, Japan
    Neurosci Lett 290:209-12. 2000
  6. ncbi request reprint Endothelium-independent and -dependent vasoactivity of 6-nitronorepinephrine
    T Nakaki
    Department of Pharmacology, Teikyo University School of Medicine, Tokyo, Japan
    Eur J Pharmacol 357:193-7. 1998
  7. ncbi request reprint Transforming growth factor-beta(1) induces apoptosis via connective tissue growth factor in human aortic smooth muscle cells
    K Hishikawa
    Department of Pharmacology, Teikyo University School of Medicine, Kaga 2 11 1, Itabashi ku, Tokyo, Japan
    Eur J Pharmacol 385:287-90. 1999
  8. ncbi request reprint Connective tissue growth factor induces apoptosis in human breast cancer cell line MCF-7
    K Hishikawa
    Department of Pharmacology, Teikyo University School of Medicine, Tokyo 173 8605, Japan
    J Biol Chem 274:37461-6. 1999
  9. ncbi request reprint Connective tissue growth factor induces apoptosis via caspase 3 in cultured human aortic smooth muscle cells
    K Hishikawa
    Department of Pharmacology, Teikyo University School of Medicine, Kaga 2 11 1, Itabashi ku, Tokyo, Japan
    Eur J Pharmacol 392:19-22. 2000
  10. pmc Functional shift from muscarinic to nicotinic cholinergic receptors involved in inositol trisphosphate and cyclic GMP accumulation during the primary culture of adrenal chromaffin cells
    T Nakaki
    Department of Pharmacology, School of Medicine, Keio University, Tokyo, Japan
    Biochem J 251:397-403. 1988

Detail Information

Publications25

  1. pmc CK2 as anti-stress factor
    Masahiko Watabe
    Department of Pharmacology Teikyo University School of Medicine Tokyo, Japan
    Commun Integr Biol 5:278-80. 2012
    ..This regulatory mechanism by phosphorylation of the serine residue may have evolutional significance...
  2. pmc Impaired glutathione synthesis in neurodegeneration
    Koji Aoyama
    Department of Pharmacology, Teikyo University School of Medicine, 2 11 1 Kaga, Itabashi, Tokyo 173 8605, Japan
    Int J Mol Sci 14:21021-44. 2013
    ..This review focuses on the significance of GSH function, the synthesis of GSH and its metabolism, and clinical disorders of GSH metabolism. A potential approach to increase brain GSH levels against neurodegeneration is also discussed. ..
  3. ncbi request reprint Learning adverse drug effects from judicial precedents
    Toshio Nakaki
    Department of Pharmacology, Teikyo University School of Medicine, 2 11 1 Kaga, Itabashi Ward, Tokyo 173 8605, Japan
    Naunyn Schmiedebergs Arch Pharmacol 366:30-2. 2002
    ..Judicial precedents provide an excellent teaching material for giving students an incentive to access web sites that are essential for healthcare professionals...
  4. ncbi request reprint [The arginine paradox]
    Toshio Nakaki
    Department of Pharmacology, Teikyo University School of Medicine, 2 11 1 Kaga, Itabashi ku, Tokyo 173 8605, Japan
    Nihon Yakurigaku Zasshi 119:7-14. 2002
    ..4) Intracellular L-citrulline, an NOS product, is a potent inhibitor of NOS so that the cells may need extra L-arginine to compete with L-citrulline inhibition...
  5. ncbi request reprint Glufosinate ammonium stimulates nitric oxide production through N-methyl D-aspartate receptors in rat cerebellum
    T Nakaki
    Department of Pharmacology, Teikyo University School of Medicine, 2 11 1 Kaga, Itabashi ku, 173 8605, Tokyo, Japan
    Neurosci Lett 290:209-12. 2000
    ..These results suggest that glufosinate ammonium stimulates nitric oxide production through NMDA receptors...
  6. ncbi request reprint Endothelium-independent and -dependent vasoactivity of 6-nitronorepinephrine
    T Nakaki
    Department of Pharmacology, Teikyo University School of Medicine, Tokyo, Japan
    Eur J Pharmacol 357:193-7. 1998
    ....
  7. ncbi request reprint Transforming growth factor-beta(1) induces apoptosis via connective tissue growth factor in human aortic smooth muscle cells
    K Hishikawa
    Department of Pharmacology, Teikyo University School of Medicine, Kaga 2 11 1, Itabashi ku, Tokyo, Japan
    Eur J Pharmacol 385:287-90. 1999
    ..Moreover, TGF-beta(1) activated caspase 3 in HASC, and the CTGF antisense oligonucleotide reduced this activation. These findings show that CTGF plays a key role in the TGF-beta(1)-induced apoptosis in HASC...
  8. ncbi request reprint Connective tissue growth factor induces apoptosis in human breast cancer cell line MCF-7
    K Hishikawa
    Department of Pharmacology, Teikyo University School of Medicine, Tokyo 173 8605, Japan
    J Biol Chem 274:37461-6. 1999
    ..Taken together, these results suggest that CTGF is a major inducer of apoptosis in the human breast cancer cell line MCF-7 and that TGF-beta-induced apoptosis in MCF-7 cells is mediated, in part, by CTGF...
  9. ncbi request reprint Connective tissue growth factor induces apoptosis via caspase 3 in cultured human aortic smooth muscle cells
    K Hishikawa
    Department of Pharmacology, Teikyo University School of Medicine, Kaga 2 11 1, Itabashi ku, Tokyo, Japan
    Eur J Pharmacol 392:19-22. 2000
    ..Moreover, r-hCTGF-induced apoptosis was significantly inhibited by an antibody to CTGF and a caspase-3 inhibitor, Z-Asp(Ome)-Glu-(Ome)Val-Asp(Ome)-FMK. These results suggest that r-hCTGF activates caspase 3 and induces apoptosis...
  10. pmc Functional shift from muscarinic to nicotinic cholinergic receptors involved in inositol trisphosphate and cyclic GMP accumulation during the primary culture of adrenal chromaffin cells
    T Nakaki
    Department of Pharmacology, School of Medicine, Keio University, Tokyo, Japan
    Biochem J 251:397-403. 1988
    ..These data show that cholinergic receptors linked to the accumulation of InsP3 and cyclic GMP and Ca2+ mobilization functionally shift from muscarinic to nicotinic during primary culture of adrenal chromaffin cells...
  11. ncbi request reprint Stimulation by ATP of inositol trisphosphate accumulation and calcium mobilization in cultured adrenal chromaffin cells
    N Sasakawa
    Department of Pharmacology, School of Medicine, Keio University, Tokyo, Japan
    J Neurochem 52:441-7. 1989
    ..These results suggest that ATP induces the formation of 1,4,5-IP3 through the P2-purinergic receptor and consequently promotes Ca2+ mobilization from intracellular storage sites in cultured adrenal chromaffin cells...
  12. ncbi request reprint Endothelium-accelerated hyporesponsiveness of norepinephrine-elicited contraction of rat aorta in the presence of bacterial lipopolysaccharide
    T Nakaki
    Department of Pharmacology, Keio University School of Medicine, Tokyo, Japan
    Eur J Pharmacol 219:311-8. 1992
    ..However, a 24-h incubation reduced the contraction even in the absence of endothelium.(ABSTRACT TRUNCATED AT 250 WORDS)..
  13. ncbi request reprint Nitration modifying function of proteins, hormones and neurotransmitters
    T Nakaki
    Department of Pharmacology, Teikyo University School of Medicine, Tokyo, Japan
    Jpn J Pharmacol 79:125-9. 1999
    ..It is still unknown whether nitration is merely a footprint of oxidative stress, an important pathway of nitric oxide metabolisms or a part of integral processes for maintaining cellular homeostasis...
  14. doi request reprint Caffeine and uric acid mediate glutathione synthesis for neuroprotection
    K Aoyama
    Department of Pharmacology, Teikyo University School of Medicine, 2 11 1 Kaga, Itabashi, Tokyo 173 8501, Japan
    Neuroscience 181:206-15. 2011
    ..These findings suggest that purine derivatives caffeine and UA induce neuronal GSH synthesis by promoting cysteine uptake, leading to neuroprotection...
  15. ncbi request reprint Vascular smooth muscle contraction induced by Na+ channel activators, veratridine and batrachotoxin
    M Shinjoh
    Department of Pharmacology, Keio University School of Medicine, Tokyo, Japan
    Eur J Pharmacol 205:199-202. 1991
    ..These results show that the activation of sodium channels on smooth muscle cells induces a contraction that is probably mediated by Ca2+ influx through voltage-dependent Ca2+ channels...
  16. ncbi request reprint Glufosinate ammonium induces convulsion through N-methyl-D-aspartate receptors in mice
    N Matsumura
    Department of Pharmacology, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, 173-8605, Tokyo, Japan
    Neurosci Lett 304:123-5. 2001
    ..These results suggest that the convulsion caused by glufosinate ammonium is mediated through NMDA receptors...
  17. ncbi request reprint [NF-kappa B as a therapeutic drug target]
    K Hishikawa
    Department of Pharmacology, Teikyo University, School of Medicine, 2 11 1 Kaga, Itabashi ku, Tokyo 173 8605, Japan
    Nihon Yakurigaku Zasshi 118:197-202. 2001
    ..Recently NF-kappa B has been shown to be the target of new drug discovery. Here, we discuss the so-called NF-kappa B inhibitors and consider the development of new therapeutic agents...
  18. ncbi request reprint Rapid increase in inositol pentakisphosphate accumulation by nicotine in cultured adrenal chromaffin cells
    N Sasakawa
    Department of Pharmacology, Keio University School of Medicine, Tokyo, Japan
    FEBS Lett 261:378-80. 1990
    ..These results suggest that inositol pentakisphosphate is rapidly increased by nicotine, a cholinergic agonist, in cultured adrenal chromaffin cells...
  19. ncbi request reprint Arginine blocks gap junctions between retinal horizontal cells
    E Miyachi
    Department of Physiology, Keio University School of Medicine, Tokyo, Japan
    Neuroreport 1:107-10. 1990
    ..These results were quite similar to those obtained by intracellular application of cGMP, suggesting that the L-arginine:nitric oxide:cGMP pathway is present in retinal horizontal cells...
  20. ncbi request reprint Static pressure regulates connective tissue growth factor expression in human mesangial cells
    K Hishikawa
    Department of Pharmacology, Teikyo University School of Medicine, Tokyo 173 8605, Japan
    J Biol Chem 276:16797-803. 2001
    ..High levels of CTGF in turn enhance extracellular matrix production and induce apoptosis in mesangial cells, and may contribute to remodeling of mesangium and ultimately glomerulosclerosis...
  21. ncbi request reprint Physiological and clinical significance of nitric oxide
    T Nakaki
    Department of Pharmacology, School of Medicine, Keio University, Tokyo, Japan
    Keio J Med 43:15-26. 1994
    ..Evidence for the pathophysiological significance of NO. is now accumulating...
  22. ncbi request reprint Reduced renal ClC-5 Cl- channel expression in spontaneously hypertensive rats with microalbuminuria
    Karo Tanaka
    Department of Pharmacology, Teikyo University School of Medicine, 2 11 1 Kaga, Itabashi, Tokyo, 173 8605, Japan
    Eur J Pharmacol 501:185-9. 2004
    ..These results implicate the ClC-5 Cl(-) channel reduction in the development of albuminuria in the early stage of essential hypertension...
  23. ncbi request reprint Antipsychotic, antidepressant, anxiolytic, and anticonvulsant drugs induce type II nitric oxide synthase mRNA in rat brain
    Eiji Suzuki
    Department of Psychiatry, Kitasato University School of Medicine, 2 1 1 Asamizodai, Sagamihara, Kanagawa 228 8520, Japan
    Neurosci Lett 333:217-9. 2002
    ..These results suggest that psychotropics modulate the gene expression of type-II nitric oxide synthase in the brain...
  24. ncbi request reprint Oral flavonoid supplementation attenuates atherosclerosis development in apolipoprotein E-deficient mice
    Keiichi Hishikawa
    Department of Clinical Renal Regeneration, University of Tokyo, Japan
    Arterioscler Thromb Vasc Biol 25:442-6. 2005
    ..We examined the effects of oral CAPE supplementation on atherogenesis in apolipoprotein E-deficient (apoE-/-) mice...
  25. pmc Musculin/MyoR is expressed in kidney side population cells and can regulate their function
    Keiichi Hishikawa
    Department of Clinical Renal Regeneration, Graduate School of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 8655, Japan
    J Cell Biol 169:921-8. 2005
    ..Our results suggest that musculin/MyoR may play important roles not only in developmental processes but also in regenerative processes in adult tissue...