Research Topics
Genomes and Genes
| H KunugiSummaryAffiliation: Teikyo University Country: Japan Publications
| Collaborators
|
Detail Information
Publications
No evidence for an association between the Glu298Asp polymorphism of the NOS3 gene and Alzheimer's diseaseH Kunugi
Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan
J Neural Transm 107:1081-4. 2000..However, the genotype and allelic distributions for the Glu298Asp polymorphism were similar for these three groups, suggesting that the Glu298Asp polymorphism of the NOS3 gene has no relevance to the development of AD in Japanese...- A novel polymorphism of the brain-derived neurotrophic factor (BDNF) gene associated with late-onset Alzheimer's diseaseH Kunugi
Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan
Mol Psychiatry 6:83-6. 2001..We obtained no evidence for the possible interactions between the BDNF and apolipoprotein E (APOE) genes, suggesting that the possible effect of the BDNF gene on the development of late-onset AD might be independent of the APOE genotype... - Cytogenetic findings in 250 schizophrenics: evidence confirming an excess of the X chromosome aneuploidies and pericentric inversion of chromosome 9H Kunugi
Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan
Schizophr Res 40:43-7. 1999.... - Obstetric complications and schizophrenia: prenatal underdevelopment and subsequent neurodevelopmental impairmentH Kunugi
Department of Psychiatry, Teikyo University School of Medicine, 11 1, Kaga 2 Chrome, Itabashi ku, Tokyo 173 8605, Japan
Br J Psychiatry Suppl 40:s25-9. 2001..Many studies have shown an association between obstetric complications and schizophrenia... - Exon/intron boundaries, novel polymorphisms, and association analysis with schizophrenia of the human synaptic vesicle monoamine transporter (SVMT) geneH Kunugi
Department of Psychiatry, Teikyo University School of Medicine 11 1, Kaga 2 Chome, Itabashi ku, Tokyo, 173 8605, Japan
Mol Psychiatry 6:456-60. 2001..Furthermore, we obtained no evidence for the major effect of the novel polymorphisms on susceptibility to schizophrenia... - No evidence for an association of polymorphisms of the tryptophan hydroxylase gene with affective disorders or attempted suicide among Japanese patientsH Kunugi
Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan
Am J Psychiatry 156:774-6. 1999..The authors examined whether polymorphisms A218C and A779C in intron 7 of the tryptophan hydroxylase gene are associated with a risk for affective disorders or suicidal behavior... - C677T polymorphism in methylenetetrahydrofolate reductase gene and psychosesH Kunugi
Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan
Mol Psychiatry 3:435-7. 1998..Our results suggest that homozygosity for the T677 allele of the MTHFR gene is unlikely to play a major role in the pathogenesis of schizophrenia or affective disorders in our sample... - Possible association of missense mutation (Gly[-63]Glu) of the neurotrophin-3 gene with Alzheimer's disease in JapaneseH Kunugi
Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan
Neurosci Lett 241:65-7. 1998..Our results suggest that the Glu(-63) allele of the NT-3 gene by itself or another mutation nearby which would be in linkage disequilibrium to the mutation is a risk factor for AD... - High and low activity alleles of catechol-O-methyltransferase gene: ethnic difference and possible association with Parkinson's diseaseH Kunugi
Department of Psychiatry, Teikyo University School of Medicine, Kaga, Itabashi ku, Tokyo, Japan
Neurosci Lett 221:202-4. 1997..017; odds ratio, 2.8, 95% CI 1.2-6.5), suggesting that homozygosity for the low activity allele may increase susceptibility to PD... - Alzheimer's disease and 5-HTTLPR polymorphism of the serotonin transporter gene: no evidence for an associationH Kunugi
Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan
Am J Med Genet 96:307-9. 2000..There was no significant difference in genotype or allele distribution between either patient group and controls in our sample, suggesting that the 5-HTTLPR does not play a major role in the pathogenesis of AD in Japanese... - A complex polymorphic region in the brain-derived neurotrophic factor (BDNF) gene confers susceptibility to bipolar disorder and affects transcriptional activityT Okada
Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
Mol Psychiatry 11:695-703. 2006..Our results suggest that the BDNF-LCPR is a functional variation that confers susceptibility to bipolar disorder and affects transcriptional activity of the BDNF gene... - Association study of C825T polymorphism of the G-protein b3 subunit gene with schizophrenia and mood disordersH Kunugi
Department of Psychiatry and Genome Research Center, Teikyo University School of Medicine, Tokyo, Japan
J Neural Transm 109:213-8. 2002..We obtained no evidence for an association of the polymorphism with any diagnostic group... - Association study of the frizzled-3 (FZD3) gene with schizophrenia and mood disordersR Hashimoto
Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
J Neural Transm 112:303-7. 2005..We failed to find significant association in the four SNPs or haplotype analysis. The FZD3 gene might not play a role in conferring susceptibility to major psychosis in our sample... - Possible association between nonsynonymous polymorphisms of the anaplastic lymphoma kinase (ALK) gene and schizophrenia in a Japanese populationH Kunugi
Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
J Neural Transm 113:1569-73. 2006..0064, odds ratio 2.4, 95% CI 1.3-4.6). These results suggest that genetic variations of the ALK gene might confer susceptibility to schizophrenia... - Association of bipolar disorder with the 5178 polymorphism in mitochondrial DNAT Kato
Department of Neuropsychiatry, Faculty of Medicine, University of Tokyo, Tokyo, Japan
Am J Med Genet 96:182-6. 2000..These results suggest that the 5178 polymorphism in mitochondrial DNA may regulate vulnerability to bipolar disorder via alteration of brain energy metabolism. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:182-186, 2000... - Association study of structural mutations of the tyrosine hydroxylase gene with schizophrenia and Parkinson's diseaseH Kunugi
Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan
Am J Med Genet 81:131-3. 1998..Thus we obtained no evidence for the involvement of the two structural mutations of the TH gene in the pathogenesis of schizophrenia or PD... - Glial cell line-derived neurotrophic factor (GDNF) gene and schizophrenia: polymorphism screening and association analysisK Lee
Department of Psychiatry, Teikyo University School of Medicine, 11 1, Kaga 2 Chome, Itabashi ku, Tokyo 173 8605, Japan
Psychiatry Res 104:11-7. 2001.... - Novel polymorphism in the promoter region of the tumor necrosis factor alpha gene: No association with narcolepsyT Kato
Department of Neuropsychiatry, Faculty of Medicine, University of Tokyo, Tokyo, Japan
Am J Med Genet 88:301-4. 1999..These results do not support our hypothesis that genetic abnormality of TNF alpha production is pathogenetic for narcolepsy... - Analysis of enhancer activity of a dinucleotide repeat polymorphism in the neurotrophin-3 gene and its association with bipolar disorderK Tadokoro
Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology, and Psychiatry, Ogawahigashi, Kodaira, Tokyo, Japan
Neuropsychobiology 50:206-10. 2004..Although the polymorphic region may have an enhancer-like effect on transcriptional activity, we obtained no evidence for allele-dependent differential effects... 
SIRT1 gene, schizophrenia and bipolar disorder in the Japanese population: an association studyT Kishi
Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
Genes Brain Behav 10:257-63. 2011..89 × 10(-15)). Also, four tagging SNPs in the SIRT1 gene were not associated with BP. In conclusion, the SIRT1 gene may play an important role in the pathophysiology of schizophrenia in the Japanese population...- Association analysis of the -308G>A promoter polymorphism of the tumor necrosis factor alpha (TNF-alpha) gene in Japanese patients with schizophreniaR Hashimoto
Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
J Neural Transm 111:217-21. 2004..We conclude that the effect of the -308G > A polymorphism on the development of schizophrenia is, if any, weak and the majority of Japanese schizophrenics are unrelated to the -308G > A polymorphism of the TNF-alpha gene... - Epigenetic aberration of the human REELIN gene in psychiatric disordersY Tamura
National Institute of Neuroscience, NCNP, Kodaira, Tokyo, Japan
Mol Psychiatry 12:519, 593-600. 2007..These data suggest the possibility that epigenetic aberration from the normal DNA methylation status of RELN may confer susceptibility to psychiatric disorders... - Glutamatergic changes in the cerebral white matter associated with schizophrenic exacerbationM Ota
Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan
Acta Psychiatr Scand 126:72-8. 2012..This study was aimed to examine several brain chemical mediators, including Glx (glutamate + glutamine), using (1)H magnetic resonance spectroscopy (MRS) in medicated patients with schizophrenia, with and without psychotic exacerbation... - Familial schizophrenia with pericentric inversion of chromosome 9: a case reportK B Lee
Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan
Schizophr Res 32:123-6. 1998..9 may vary depending on the location of breakpoints. Thus our cases may be valuable material to localize breakpoints on chromosome 9, which may lead to cloning of a susceptibility gene for schizophrenia... - No changes in paired viral antibody titers during the course of acute schizophreniaR Fukuda
Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan
Neuropsychobiology 40:57-62. 1999..It is unlikely that the active infection or reactivation of these viruses has direct causal relationship to schizophrenia in these patients... - Early parental loss and depressive disorder in JapanH Kunugi
Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan
Eur Arch Psychiatry Clin Neurosci 245:109-13. 1995..Separation from either parent also showed a trend towards an increased incidence in the depressive group. No significant difference in the incidence of early paternal death was found... 
13C-phenylalanine breath test detects altered phenylalanine kinetics in schizophrenia patientsT Teraishi
Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
Transl Psychiatry 2:e119. 2012..Animal experiments suggest that the observed changes are unlikely to be attributable to antipsychotic medication...- Glucocorticoid attenuates brain-derived neurotrophic factor-dependent upregulation of glutamate receptors via the suppression of microRNA-132 expressionH Kawashima
Administrative Section of Radiation Protection, National Institute of Neuroscience, National Center of Neurology and Psychiatry NCNP, Tokyo, Japan
Neuroscience 165:1301-11. 2010..We demonstrate that the exposure of neurons to an excess glucocorticoid results in a decrease in the BDNF-dependent neuronal function via suppressing miR-132 expression... - Pharmacotherapeutic Determinants for QTc Interval Prolongation in Japanese Patients with Mood DisorderH Okayasu
Department of Psychiatry, Dokkyo Medical University School of Medicine, Mibu, Japan
Pharmacopsychiatry 45:279-83. 2012..The selective serotonin reuptake inhibitors investigated (fluvoxamine, paroxetine, sertraline) were not indicated as risk factors for QTc prolongation... - Plasma levels of vascular endothelial growth factor and fibroblast growth factor 2 in patients with major depressive disordersM Takebayashi
Department of Psychiatry, National Hospital Organization NHO Kure Medical Center, 3 1 Aoyama, Kure 737 0023, Japan
J Neural Transm 117:1119-22. 2010..Although this is a preliminary study, altered VEGF levels might be involved in the pathophysiology of MDD... - [Low serum cholesterol and suicidal behavior]H Kunugi
Department of Psychiatry, Teikyo University School of Medicine
Nippon Rinsho 59:1599-604. 2001..Clinicians should be aware of potential effects of lowering cholesterol interventions on behavioral symptoms... - Possible effect of the APOE epsilon 4 allele on the hippocampal volume and asymmetry in schizophreniaT Hata
Am J Med Genet 114:641-2. 2002 - Pituitary adenylate cyclase-activating polypeptide is associated with schizophreniaR Hashimoto
The Osaka Hamamatsu Joint Research Center for Child Mental Development, Osaka University Graduate School of Medicine, Yamadaoka, Suita, Osaka, Japan
Mol Psychiatry 12:1026-32. 2007..These convergent data suggest that alterations in PACAP signaling might contribute to the pathogenesis of schizophrenia... - No association between Parkinson's disease and low-activity alleles of catechol O-methyltransferaseF Hoda
Section of Molecular Genetics, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, United Kingdom
Biochem Biophys Res Commun 228:780-4. 1996..However it remains possible that allelic variation in COMT influences severity, type of pathology or treatment response to levodopa or COMT inhibitors...