H Kunugi

Summary

Affiliation: Teikyo University
Country: Japan

Publications

  1. ncbi request reprint No evidence for an association between the Glu298Asp polymorphism of the NOS3 gene and Alzheimer's disease
    H Kunugi
    Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan
    J Neural Transm 107:1081-4. 2000
  2. ncbi request reprint A novel polymorphism of the brain-derived neurotrophic factor (BDNF) gene associated with late-onset Alzheimer's disease
    H Kunugi
    Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan
    Mol Psychiatry 6:83-6. 2001
  3. ncbi request reprint Cytogenetic findings in 250 schizophrenics: evidence confirming an excess of the X chromosome aneuploidies and pericentric inversion of chromosome 9
    H Kunugi
    Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan
    Schizophr Res 40:43-7. 1999
  4. ncbi request reprint Obstetric complications and schizophrenia: prenatal underdevelopment and subsequent neurodevelopmental impairment
    H Kunugi
    Department of Psychiatry, Teikyo University School of Medicine, 11 1, Kaga 2 Chrome, Itabashi ku, Tokyo 173 8605, Japan
    Br J Psychiatry Suppl 40:s25-9. 2001
  5. ncbi request reprint Exon/intron boundaries, novel polymorphisms, and association analysis with schizophrenia of the human synaptic vesicle monoamine transporter (SVMT) gene
    H Kunugi
    Department of Psychiatry, Teikyo University School of Medicine 11 1, Kaga 2 Chome, Itabashi ku, Tokyo, 173 8605, Japan
    Mol Psychiatry 6:456-60. 2001
  6. ncbi request reprint No evidence for an association of polymorphisms of the tryptophan hydroxylase gene with affective disorders or attempted suicide among Japanese patients
    H Kunugi
    Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan
    Am J Psychiatry 156:774-6. 1999
  7. ncbi request reprint C677T polymorphism in methylenetetrahydrofolate reductase gene and psychoses
    H Kunugi
    Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan
    Mol Psychiatry 3:435-7. 1998
  8. ncbi request reprint Possible association of missense mutation (Gly[-63]Glu) of the neurotrophin-3 gene with Alzheimer's disease in Japanese
    H Kunugi
    Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan
    Neurosci Lett 241:65-7. 1998
  9. ncbi request reprint High and low activity alleles of catechol-O-methyltransferase gene: ethnic difference and possible association with Parkinson's disease
    H Kunugi
    Department of Psychiatry, Teikyo University School of Medicine, Kaga, Itabashi ku, Tokyo, Japan
    Neurosci Lett 221:202-4. 1997
  10. ncbi request reprint Alzheimer's disease and 5-HTTLPR polymorphism of the serotonin transporter gene: no evidence for an association
    H Kunugi
    Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan
    Am J Med Genet 96:307-9. 2000

Collaborators

Detail Information

Publications35

  1. ncbi request reprint No evidence for an association between the Glu298Asp polymorphism of the NOS3 gene and Alzheimer's disease
    H Kunugi
    Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan
    J Neural Transm 107:1081-4. 2000
    ..However, the genotype and allelic distributions for the Glu298Asp polymorphism were similar for these three groups, suggesting that the Glu298Asp polymorphism of the NOS3 gene has no relevance to the development of AD in Japanese...
  2. ncbi request reprint A novel polymorphism of the brain-derived neurotrophic factor (BDNF) gene associated with late-onset Alzheimer's disease
    H Kunugi
    Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan
    Mol Psychiatry 6:83-6. 2001
    ..We obtained no evidence for the possible interactions between the BDNF and apolipoprotein E (APOE) genes, suggesting that the possible effect of the BDNF gene on the development of late-onset AD might be independent of the APOE genotype...
  3. ncbi request reprint Cytogenetic findings in 250 schizophrenics: evidence confirming an excess of the X chromosome aneuploidies and pericentric inversion of chromosome 9
    H Kunugi
    Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan
    Schizophr Res 40:43-7. 1999
    ....
  4. ncbi request reprint Obstetric complications and schizophrenia: prenatal underdevelopment and subsequent neurodevelopmental impairment
    H Kunugi
    Department of Psychiatry, Teikyo University School of Medicine, 11 1, Kaga 2 Chrome, Itabashi ku, Tokyo 173 8605, Japan
    Br J Psychiatry Suppl 40:s25-9. 2001
    ..Many studies have shown an association between obstetric complications and schizophrenia...
  5. ncbi request reprint Exon/intron boundaries, novel polymorphisms, and association analysis with schizophrenia of the human synaptic vesicle monoamine transporter (SVMT) gene
    H Kunugi
    Department of Psychiatry, Teikyo University School of Medicine 11 1, Kaga 2 Chome, Itabashi ku, Tokyo, 173 8605, Japan
    Mol Psychiatry 6:456-60. 2001
    ..Furthermore, we obtained no evidence for the major effect of the novel polymorphisms on susceptibility to schizophrenia...
  6. ncbi request reprint No evidence for an association of polymorphisms of the tryptophan hydroxylase gene with affective disorders or attempted suicide among Japanese patients
    H Kunugi
    Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan
    Am J Psychiatry 156:774-6. 1999
    ..The authors examined whether polymorphisms A218C and A779C in intron 7 of the tryptophan hydroxylase gene are associated with a risk for affective disorders or suicidal behavior...
  7. ncbi request reprint C677T polymorphism in methylenetetrahydrofolate reductase gene and psychoses
    H Kunugi
    Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan
    Mol Psychiatry 3:435-7. 1998
    ..Our results suggest that homozygosity for the T677 allele of the MTHFR gene is unlikely to play a major role in the pathogenesis of schizophrenia or affective disorders in our sample...
  8. ncbi request reprint Possible association of missense mutation (Gly[-63]Glu) of the neurotrophin-3 gene with Alzheimer's disease in Japanese
    H Kunugi
    Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan
    Neurosci Lett 241:65-7. 1998
    ..Our results suggest that the Glu(-63) allele of the NT-3 gene by itself or another mutation nearby which would be in linkage disequilibrium to the mutation is a risk factor for AD...
  9. ncbi request reprint High and low activity alleles of catechol-O-methyltransferase gene: ethnic difference and possible association with Parkinson's disease
    H Kunugi
    Department of Psychiatry, Teikyo University School of Medicine, Kaga, Itabashi ku, Tokyo, Japan
    Neurosci Lett 221:202-4. 1997
    ..017; odds ratio, 2.8, 95% CI 1.2-6.5), suggesting that homozygosity for the low activity allele may increase susceptibility to PD...
  10. ncbi request reprint Alzheimer's disease and 5-HTTLPR polymorphism of the serotonin transporter gene: no evidence for an association
    H Kunugi
    Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan
    Am J Med Genet 96:307-9. 2000
    ..There was no significant difference in genotype or allele distribution between either patient group and controls in our sample, suggesting that the 5-HTTLPR does not play a major role in the pathogenesis of AD in Japanese...
  11. ncbi request reprint A complex polymorphic region in the brain-derived neurotrophic factor (BDNF) gene confers susceptibility to bipolar disorder and affects transcriptional activity
    T Okada
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
    Mol Psychiatry 11:695-703. 2006
    ..Our results suggest that the BDNF-LCPR is a functional variation that confers susceptibility to bipolar disorder and affects transcriptional activity of the BDNF gene...
  12. ncbi request reprint Association study of C825T polymorphism of the G-protein b3 subunit gene with schizophrenia and mood disorders
    H Kunugi
    Department of Psychiatry and Genome Research Center, Teikyo University School of Medicine, Tokyo, Japan
    J Neural Transm 109:213-8. 2002
    ..We obtained no evidence for an association of the polymorphism with any diagnostic group...
  13. ncbi request reprint Association study of the frizzled-3 (FZD3) gene with schizophrenia and mood disorders
    R Hashimoto
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
    J Neural Transm 112:303-7. 2005
    ..We failed to find significant association in the four SNPs or haplotype analysis. The FZD3 gene might not play a role in conferring susceptibility to major psychosis in our sample...
  14. ncbi request reprint Possible association between nonsynonymous polymorphisms of the anaplastic lymphoma kinase (ALK) gene and schizophrenia in a Japanese population
    H Kunugi
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
    J Neural Transm 113:1569-73. 2006
    ..0064, odds ratio 2.4, 95% CI 1.3-4.6). These results suggest that genetic variations of the ALK gene might confer susceptibility to schizophrenia...
  15. ncbi request reprint Association of bipolar disorder with the 5178 polymorphism in mitochondrial DNA
    T Kato
    Department of Neuropsychiatry, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Am J Med Genet 96:182-6. 2000
    ..These results suggest that the 5178 polymorphism in mitochondrial DNA may regulate vulnerability to bipolar disorder via alteration of brain energy metabolism. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:182-186, 2000...
  16. ncbi request reprint Glial cell line-derived neurotrophic factor (GDNF) gene and schizophrenia: polymorphism screening and association analysis
    K Lee
    Department of Psychiatry, Teikyo University School of Medicine, 11 1, Kaga 2 Chome, Itabashi ku, Tokyo 173 8605, Japan
    Psychiatry Res 104:11-7. 2001
    ....
  17. ncbi request reprint Association study of structural mutations of the tyrosine hydroxylase gene with schizophrenia and Parkinson's disease
    H Kunugi
    Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan
    Am J Med Genet 81:131-3. 1998
    ..Thus we obtained no evidence for the involvement of the two structural mutations of the TH gene in the pathogenesis of schizophrenia or PD...
  18. ncbi request reprint Novel polymorphism in the promoter region of the tumor necrosis factor alpha gene: No association with narcolepsy
    T Kato
    Department of Neuropsychiatry, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Am J Med Genet 88:301-4. 1999
    ..These results do not support our hypothesis that genetic abnormality of TNF alpha production is pathogenetic for narcolepsy...
  19. ncbi request reprint Analysis of enhancer activity of a dinucleotide repeat polymorphism in the neurotrophin-3 gene and its association with bipolar disorder
    K Tadokoro
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology, and Psychiatry, Ogawahigashi, Kodaira, Tokyo, Japan
    Neuropsychobiology 50:206-10. 2004
    ..Although the polymorphic region may have an enhancer-like effect on transcriptional activity, we obtained no evidence for allele-dependent differential effects...
  20. doi request reprint SIRT1 gene, schizophrenia and bipolar disorder in the Japanese population: an association study
    T Kishi
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
    Genes Brain Behav 10:257-63. 2011
    ..89 × 10(-15)). Also, four tagging SNPs in the SIRT1 gene were not associated with BP. In conclusion, the SIRT1 gene may play an important role in the pathophysiology of schizophrenia in the Japanese population...
  21. doi request reprint Pharmacotherapeutic determinants for QTc interval prolongation in Japanese patients with mood disorder
    H Okayasu
    Department of Psychiatry, Dokkyo Medical University School of Medicine, Mibu, Japan
    Pharmacopsychiatry 45:279-83. 2012
    ..The selective serotonin reuptake inhibitors investigated (fluvoxamine, paroxetine, sertraline) were not indicated as risk factors for QTc prolongation...
  22. ncbi request reprint Association analysis of the -308G>A promoter polymorphism of the tumor necrosis factor alpha (TNF-alpha) gene in Japanese patients with schizophrenia
    R Hashimoto
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
    J Neural Transm 111:217-21. 2004
    ..We conclude that the effect of the -308G > A polymorphism on the development of schizophrenia is, if any, weak and the majority of Japanese schizophrenics are unrelated to the -308G > A polymorphism of the TNF-alpha gene...
  23. ncbi request reprint Epigenetic aberration of the human REELIN gene in psychiatric disorders
    Y Tamura
    National Institute of Neuroscience, NCNP, Kodaira, Tokyo, Japan
    Mol Psychiatry 12:519, 593-600. 2007
    ..These data suggest the possibility that epigenetic aberration from the normal DNA methylation status of RELN may confer susceptibility to psychiatric disorders...
  24. doi request reprint Possible association of CUX1 gene polymorphisms with antidepressant response in major depressive disorder
    D Sasayama
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan
    Pharmacogenomics J 13:354-8. 2013
    ..0000023 and 0.0000040, respectively. Our results provide the first evidence that polymorphisms of the CUX1 gene may be associated with response to antidepressant treatment in Japanese patients with MDD. ..
  25. pmc 13C-phenylalanine breath test detects altered phenylalanine kinetics in schizophrenia patients
    T Teraishi
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
    Transl Psychiatry 2:e119. 2012
    ..Animal experiments suggest that the observed changes are unlikely to be attributable to antipsychotic medication...
  26. doi request reprint Glutamatergic changes in the cerebral white matter associated with schizophrenic exacerbation
    M Ota
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan
    Acta Psychiatr Scand 126:72-8. 2012
    ..This study was aimed to examine several brain chemical mediators, including Glx (glutamate + glutamine), using (1)H magnetic resonance spectroscopy (MRS) in medicated patients with schizophrenia, with and without psychotic exacerbation...
  27. ncbi request reprint Early parental loss and depressive disorder in Japan
    H Kunugi
    Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan
    Eur Arch Psychiatry Clin Neurosci 245:109-13. 1995
    ..Separation from either parent also showed a trend towards an increased incidence in the depressive group. No significant difference in the incidence of early paternal death was found...
  28. ncbi request reprint No changes in paired viral antibody titers during the course of acute schizophrenia
    R Fukuda
    Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan
    Neuropsychobiology 40:57-62. 1999
    ..It is unlikely that the active infection or reactivation of these viruses has direct causal relationship to schizophrenia in these patients...
  29. ncbi request reprint Familial schizophrenia with pericentric inversion of chromosome 9: a case report
    K B Lee
    Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan
    Schizophr Res 32:123-6. 1998
    ..9 may vary depending on the location of breakpoints. Thus our cases may be valuable material to localize breakpoints on chromosome 9, which may lead to cloning of a susceptibility gene for schizophrenia...
  30. doi request reprint Glucocorticoid attenuates brain-derived neurotrophic factor-dependent upregulation of glutamate receptors via the suppression of microRNA-132 expression
    H Kawashima
    Administrative Section of Radiation Protection, National Institute of Neuroscience, National Center of Neurology and Psychiatry NCNP, Tokyo, Japan
    Neuroscience 165:1301-11. 2010
    ..We demonstrate that the exposure of neurons to an excess glucocorticoid results in a decrease in the BDNF-dependent neuronal function via suppressing miR-132 expression...
  31. doi request reprint Plasma levels of vascular endothelial growth factor and fibroblast growth factor 2 in patients with major depressive disorders
    M Takebayashi
    Department of Psychiatry, National Hospital Organization NHO Kure Medical Center, 3 1 Aoyama, Kure 737 0023, Japan
    J Neural Transm 117:1119-22. 2010
    ..Although this is a preliminary study, altered VEGF levels might be involved in the pathophysiology of MDD...
  32. ncbi request reprint [Low serum cholesterol and suicidal behavior]
    H Kunugi
    Department of Psychiatry, Teikyo University School of Medicine
    Nippon Rinsho 59:1599-604. 2001
    ..Clinicians should be aware of potential effects of lowering cholesterol interventions on behavioral symptoms...
  33. ncbi request reprint Possible effect of the APOE epsilon 4 allele on the hippocampal volume and asymmetry in schizophrenia
    T Hata
    Am J Med Genet 114:641-2. 2002
  34. ncbi request reprint Pituitary adenylate cyclase-activating polypeptide is associated with schizophrenia
    R Hashimoto
    The Osaka Hamamatsu Joint Research Center for Child Mental Development, Osaka University Graduate School of Medicine, Yamadaoka, Suita, Osaka, Japan
    Mol Psychiatry 12:1026-32. 2007
    ..These convergent data suggest that alterations in PACAP signaling might contribute to the pathogenesis of schizophrenia...
  35. ncbi request reprint No association between Parkinson's disease and low-activity alleles of catechol O-methyltransferase
    F Hoda
    Section of Molecular Genetics, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, United Kingdom
    Biochem Biophys Res Commun 228:780-4. 1996
    ..However it remains possible that allelic variation in COMT influences severity, type of pathology or treatment response to levodopa or COMT inhibitors...