Kayoko Kita

Summary

Affiliation: Teikyo University
Country: Japan

Publications

  1. ncbi Diphenylarsinic acid promotes degradation of glutaminase C by mitochondrial Lon protease
    Kayoko Kita
    Laboratory of Toxicology, Faculty of Pharma Science, Teikyo University, Tokyo, Japan
    J Biol Chem 287:18163-72. 2012
  2. ncbi Down-regulation of glutaminase C in human hepatocarcinoma cell by diphenylarsinic acid, a degradation product of chemical warfare agents
    Kayoko Kita
    Laboratory of Toxicology, Faculty of Pharmaceutical Sciences, Teikyo University, 1091 1 Sagamiko chou, Sagamihara, Kanagawa 229 0195, Japan
    Toxicol Appl Pharmacol 220:262-70. 2007
  3. ncbi Structure-effect relationship in the down-regulation of glutaminase in cultured human cells by phenylarsenic compounds
    Kayoko Kita
    Faculty of Pharmaceutical Sciences, Teikyo University, 1091 1 Sagamiko chou, Sagamihara, Kanagawa 229 0195, Japan
    Toxicology 258:157-63. 2009
  4. ncbi Trivalent dimethylarsenic compound induces histone H3 phosphorylation and abnormal localization of Aurora B kinase in HepG2 cells
    Toshihide Suzuki
    Laboratory of Toxicology, Faculty of Pharmaceutical Sciences, Teikyo University, 1091 1 Sagamiko cho, Sagamihara, Kanagawa 229 0195, Japan
    Toxicol Appl Pharmacol 241:275-82. 2009
  5. ncbi Glutathione plays a role in regulating the formation of toxic reactive intermediates from diphenylarsinic acid
    Kenji Kinoshita
    Laboratory of Toxicology, Faculty of Pharmaceutical Sciences, Teikyo University, Sagamiko, Kanagawa 199-0195, Japan
    Toxicology 225:142-9. 2006
  6. ncbi Cytotoxic, genotoxic and cell-cycle disruptive effects of thio-dimethylarsinate in cultured human cells and the role of glutathione
    Takafumi Ochi
    Laboratory of Toxicology, Faculty of Pharmaceutical Sciences, Teikyo University, Sagamiko, Kanagawa 229 0195, Japan
    Toxicol Appl Pharmacol 228:59-67. 2008
  7. ncbi siRNA-mediated inhibition of phosphatidylinositol glycan Class B (PIGB) confers resistance to methylmercury in HEK293 cells
    Gi Wook Hwang
    Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan
    J Toxicol Sci 32:581-3. 2007

Collaborators

Detail Information

Publications7

  1. ncbi Diphenylarsinic acid promotes degradation of glutaminase C by mitochondrial Lon protease
    Kayoko Kita
    Laboratory of Toxicology, Faculty of Pharma Science, Teikyo University, Tokyo, Japan
    J Biol Chem 287:18163-72. 2012
    ..These results suggest that degradation of native tetrameric GAC by DPAA may be a trigger in GAC protein degradation by Lon protease...
  2. ncbi Down-regulation of glutaminase C in human hepatocarcinoma cell by diphenylarsinic acid, a degradation product of chemical warfare agents
    Kayoko Kita
    Laboratory of Toxicology, Faculty of Pharmaceutical Sciences, Teikyo University, 1091 1 Sagamiko chou, Sagamihara, Kanagawa 229 0195, Japan
    Toxicol Appl Pharmacol 220:262-70. 2007
    ..Selective inhibition of GAC expression by DPAA may be a cause of dysfunction of glutamatergic neuronal transmission and the resultant neurological impairments...
  3. ncbi Structure-effect relationship in the down-regulation of glutaminase in cultured human cells by phenylarsenic compounds
    Kayoko Kita
    Faculty of Pharmaceutical Sciences, Teikyo University, 1091 1 Sagamiko chou, Sagamihara, Kanagawa 229 0195, Japan
    Toxicology 258:157-63. 2009
    ..In addition, the fact that it was only the arsenicals detected in Kamisu that were effective in suppressing glutaminase provides insights into the cause of the arsenic intoxication at Kamisu...
  4. ncbi Trivalent dimethylarsenic compound induces histone H3 phosphorylation and abnormal localization of Aurora B kinase in HepG2 cells
    Toshihide Suzuki
    Laboratory of Toxicology, Faculty of Pharmaceutical Sciences, Teikyo University, 1091 1 Sagamiko cho, Sagamihara, Kanagawa 229 0195, Japan
    Toxicol Appl Pharmacol 241:275-82. 2009
    ..These results provide insight into the mechanism of arsenic tumorigenesis...
  5. ncbi Glutathione plays a role in regulating the formation of toxic reactive intermediates from diphenylarsinic acid
    Kenji Kinoshita
    Laboratory of Toxicology, Faculty of Pharmaceutical Sciences, Teikyo University, Sagamiko, Kanagawa 199-0195, Japan
    Toxicology 225:142-9. 2006
    ....
  6. ncbi Cytotoxic, genotoxic and cell-cycle disruptive effects of thio-dimethylarsinate in cultured human cells and the role of glutathione
    Takafumi Ochi
    Laboratory of Toxicology, Faculty of Pharmaceutical Sciences, Teikyo University, Sagamiko, Kanagawa 229 0195, Japan
    Toxicol Appl Pharmacol 228:59-67. 2008
    ..These findings suggest that the presence of thio-DMA in human urine has implications for human health in terms of arsenic metabolism and toxicity...
  7. ncbi siRNA-mediated inhibition of phosphatidylinositol glycan Class B (PIGB) confers resistance to methylmercury in HEK293 cells
    Gi Wook Hwang
    Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan
    J Toxicol Sci 32:581-3. 2007
    ..Screening revealed that downregulation of the gene for phosphatidylinositol glycan class B (PIGB) by siRNA confers resistance to methylmercury in HEK293 cells...