Kayoko Kita

Summary

Affiliation: Teikyo University
Country: Japan

Publications

  1. pmc Diphenylarsinic acid promotes degradation of glutaminase C by mitochondrial Lon protease
    Kayoko Kita
    Laboratory of Toxicology, Faculty of Pharma Science, Teikyo University, Tokyo, Japan
    J Biol Chem 287:18163-72. 2012
  2. ncbi request reprint Down-regulation of glutaminase C in human hepatocarcinoma cell by diphenylarsinic acid, a degradation product of chemical warfare agents
    Kayoko Kita
    Laboratory of Toxicology, Faculty of Pharmaceutical Sciences, Teikyo University, 1091 1 Sagamiko chou, Sagamihara, Kanagawa 229 0195, Japan
    Toxicol Appl Pharmacol 220:262-70. 2007
  3. doi request reprint Structure-effect relationship in the down-regulation of glutaminase in cultured human cells by phenylarsenic compounds
    Kayoko Kita
    Faculty of Pharmaceutical Sciences, Teikyo University, 1091 1 Sagamiko chou, Sagamihara, Kanagawa 229 0195, Japan
    Toxicology 258:157-63. 2009
  4. doi request reprint Trivalent dimethylarsenic compound induces histone H3 phosphorylation and abnormal localization of Aurora B kinase in HepG2 cells
    Toshihide Suzuki
    Laboratory of Toxicology, Faculty of Pharmaceutical Sciences, Teikyo University, 1091 1 Sagamiko cho, Sagamihara, Kanagawa 229 0195, Japan
    Toxicol Appl Pharmacol 241:275-82. 2009
  5. doi request reprint Phosphorylation of histone H3 at serine 10 has an essential role in arsenite-induced expression of FOS, EGR1 and IL8 mRNA in cultured human cell lines
    Toshihide Suzuki
    Faculty of Pharmaceutical Sciences, Teikyo University, 1091 1 Sagamihara, Kanagawa, 252 5195, Japan
    J Appl Toxicol 33:746-55. 2013
  6. ncbi request reprint Glutathione plays a role in regulating the formation of toxic reactive intermediates from diphenylarsinic acid
    Kenji Kinoshita
    Laboratory of Toxicology, Faculty of Pharmaceutical Sciences, Teikyo University, Sagamiko, Kanagawa 199 0195, Japan
    Toxicology 225:142-9. 2006
  7. doi request reprint Cytotoxic, genotoxic and cell-cycle disruptive effects of thio-dimethylarsinate in cultured human cells and the role of glutathione
    Takafumi Ochi
    Laboratory of Toxicology, Faculty of Pharmaceutical Sciences, Teikyo University, Sagamiko, Kanagawa 229 0195, Japan
    Toxicol Appl Pharmacol 228:59-67. 2008
  8. ncbi request reprint siRNA-mediated inhibition of phosphatidylinositol glycan Class B (PIGB) confers resistance to methylmercury in HEK293 cells
    Gi Wook Hwang
    Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan
    J Toxicol Sci 32:581-3. 2007

Collaborators

Detail Information

Publications8

  1. pmc Diphenylarsinic acid promotes degradation of glutaminase C by mitochondrial Lon protease
    Kayoko Kita
    Laboratory of Toxicology, Faculty of Pharma Science, Teikyo University, Tokyo, Japan
    J Biol Chem 287:18163-72. 2012
    ..These results suggest that degradation of native tetrameric GAC by DPAA may be a trigger in GAC protein degradation by Lon protease...
  2. ncbi request reprint Down-regulation of glutaminase C in human hepatocarcinoma cell by diphenylarsinic acid, a degradation product of chemical warfare agents
    Kayoko Kita
    Laboratory of Toxicology, Faculty of Pharmaceutical Sciences, Teikyo University, 1091 1 Sagamiko chou, Sagamihara, Kanagawa 229 0195, Japan
    Toxicol Appl Pharmacol 220:262-70. 2007
    ..Selective inhibition of GAC expression by DPAA may be a cause of dysfunction of glutamatergic neuronal transmission and the resultant neurological impairments...
  3. doi request reprint Structure-effect relationship in the down-regulation of glutaminase in cultured human cells by phenylarsenic compounds
    Kayoko Kita
    Faculty of Pharmaceutical Sciences, Teikyo University, 1091 1 Sagamiko chou, Sagamihara, Kanagawa 229 0195, Japan
    Toxicology 258:157-63. 2009
    ..In addition, the fact that it was only the arsenicals detected in Kamisu that were effective in suppressing glutaminase provides insights into the cause of the arsenic intoxication at Kamisu...
  4. doi request reprint Trivalent dimethylarsenic compound induces histone H3 phosphorylation and abnormal localization of Aurora B kinase in HepG2 cells
    Toshihide Suzuki
    Laboratory of Toxicology, Faculty of Pharmaceutical Sciences, Teikyo University, 1091 1 Sagamiko cho, Sagamihara, Kanagawa 229 0195, Japan
    Toxicol Appl Pharmacol 241:275-82. 2009
    ..These results provide insight into the mechanism of arsenic tumorigenesis...
  5. doi request reprint Phosphorylation of histone H3 at serine 10 has an essential role in arsenite-induced expression of FOS, EGR1 and IL8 mRNA in cultured human cell lines
    Toshihide Suzuki
    Faculty of Pharmaceutical Sciences, Teikyo University, 1091 1 Sagamihara, Kanagawa, 252 5195, Japan
    J Appl Toxicol 33:746-55. 2013
    ..Aberrant gene expression seems to be an important cause of cytotoxicity and may have some relation to iAs(III) carcinogenicity...
  6. ncbi request reprint Glutathione plays a role in regulating the formation of toxic reactive intermediates from diphenylarsinic acid
    Kenji Kinoshita
    Laboratory of Toxicology, Faculty of Pharmaceutical Sciences, Teikyo University, Sagamiko, Kanagawa 199 0195, Japan
    Toxicology 225:142-9. 2006
    ....
  7. doi request reprint Cytotoxic, genotoxic and cell-cycle disruptive effects of thio-dimethylarsinate in cultured human cells and the role of glutathione
    Takafumi Ochi
    Laboratory of Toxicology, Faculty of Pharmaceutical Sciences, Teikyo University, Sagamiko, Kanagawa 229 0195, Japan
    Toxicol Appl Pharmacol 228:59-67. 2008
    ..These findings suggest that the presence of thio-DMA in human urine has implications for human health in terms of arsenic metabolism and toxicity...
  8. ncbi request reprint siRNA-mediated inhibition of phosphatidylinositol glycan Class B (PIGB) confers resistance to methylmercury in HEK293 cells
    Gi Wook Hwang
    Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan
    J Toxicol Sci 32:581-3. 2007
    ..Screening revealed that downregulation of the gene for phosphatidylinositol glycan class B (PIGB) by siRNA confers resistance to methylmercury in HEK293 cells...