Masahiro Kamata

Summary

Affiliation: Teikyo University
Country: Japan

Publications

  1. doi request reprint Decreased serum LL-37 and vitamin D3 levels in atopic dermatitis: relationship between IL-31 and oncostatin M
    N Kanda
    Department of Dermatology, School of Medicine, Teikyo University, Tokyo, Japan
    Allergy 67:804-12. 2012
  2. doi request reprint Increased serum human β-defensin-2 levels in atopic dermatitis: relationship to IL-22 and oncostatin M
    Naoko Kanda
    Department of Dermatology, Teikyo University, School of Medicine, 11 1, Kaga 2, Itabashi ku, Tokyo 173 8605, Japan
    Immunobiology 217:436-45. 2012
  3. doi request reprint Human β-defensin-2 enhances IFN-γ and IL-10 production and suppresses IL-17 production in T cells
    Naoko Kanda
    Department of Dermatology, Teikyo University School of Medicine, 2 11 1, Kaga, Itabashi ku, Tokyo 173 8605, Japan
    J Leukoc Biol 89:935-44. 2011
  4. ncbi request reprint Prolactin enhances interferon-gamma-induced production of CXC ligand 9 (CXCL9), CXCL10, and CXCL11 in human keratinocytes
    Naoko Kanda
    Department of Dermatology, Teikyo University School of Medicine, Itabashi ku, Tokyo 173 8605, Japan
    Endocrinology 148:2317-25. 2007
  5. ncbi request reprint Suppressive effects of antimycotics on tumor necrosis factor-alpha-induced CCL27, CCL2, and CCL5 production in human keratinocytes
    Naoko Kanda
    Department of Dermatology, Teikyo University School of Medicine, 11 1, Kaga 2, Itabashi ku, Tokyo 173 8605, Japan
    Biochem Pharmacol 72:463-73. 2006
  6. ncbi request reprint IL-17 suppresses TNF-alpha-induced CCL27 production through induction of COX-2 in human keratinocytes
    Naoko Kanda
    Department of Dermatology, Teikyo University, School of Medicine, Tokyo, Japan
    J Allergy Clin Immunol 116:1144-50. 2005
  7. ncbi request reprint Prostaglandin E2 enhances neurotrophin-4 production via EP3 receptor in human keratinocytes
    Naoko Kanda
    Department of Dermatology, Teikyo University, School of Medicine, Tokyo, Japan
    J Pharmacol Exp Ther 315:796-804. 2005
  8. ncbi request reprint Regulatory roles of sex hormones in cutaneous biology and immunology
    Naoko Kanda
    Department of Dermatology, School of Medicine, Teikyo University, 11 1, Kaga 2, Itabashi ku, Tokyo 173 8605, Japan
    J Dermatol Sci 38:1-7. 2005
  9. ncbi request reprint Prostaglandin E(2) suppresses CCL27 production through EP2 and EP3 receptors in human keratinocytes
    Naoko Kanda
    Department of Pathology, Teikyo University School of Medicine, Tokyo, Japan
    J Allergy Clin Immunol 114:1403-9. 2004
  10. ncbi request reprint 17beta-estradiol enhances the production of granulocyte-macrophage colony-stimulating factor in human keratinocytes
    Naoko Kanda
    Department of Dermatology, Teikyo University, School of Medicine, Kaga, Itabashi ku, Tokyo, Japan
    J Invest Dermatol 123:329-37. 2004

Collaborators

Detail Information

Publications50

  1. doi request reprint Decreased serum LL-37 and vitamin D3 levels in atopic dermatitis: relationship between IL-31 and oncostatin M
    N Kanda
    Department of Dermatology, School of Medicine, Teikyo University, Tokyo, Japan
    Allergy 67:804-12. 2012
    ..Vitamin D3 enhances LL-37 production in keratinocytes. This study aimed to examine the serum levels of LL-37 and vitamin D3 and their regulation of cytokine production in patients with AD...
  2. doi request reprint Increased serum human β-defensin-2 levels in atopic dermatitis: relationship to IL-22 and oncostatin M
    Naoko Kanda
    Department of Dermatology, Teikyo University, School of Medicine, 11 1, Kaga 2, Itabashi ku, Tokyo 173 8605, Japan
    Immunobiology 217:436-45. 2012
    ..IL-22 and oncostatin M may enhance hBD-2 production via STAT3 in keratinocytes, while hBD-2 may enhance IL-22 and oncostatin M production in T cells. hBD-3 may enhance T(H)2 responses...
  3. doi request reprint Human β-defensin-2 enhances IFN-γ and IL-10 production and suppresses IL-17 production in T cells
    Naoko Kanda
    Department of Dermatology, Teikyo University School of Medicine, 2 11 1, Kaga, Itabashi ku, Tokyo 173 8605, Japan
    J Leukoc Biol 89:935-44. 2011
    ....
  4. ncbi request reprint Prolactin enhances interferon-gamma-induced production of CXC ligand 9 (CXCL9), CXCL10, and CXCL11 in human keratinocytes
    Naoko Kanda
    Department of Dermatology, Teikyo University School of Medicine, Itabashi ku, Tokyo 173 8605, Japan
    Endocrinology 148:2317-25. 2007
    ..Prolactin may promote type 1 T cell infiltration into psoriatic lesions via these chemokines...
  5. ncbi request reprint Suppressive effects of antimycotics on tumor necrosis factor-alpha-induced CCL27, CCL2, and CCL5 production in human keratinocytes
    Naoko Kanda
    Department of Dermatology, Teikyo University School of Medicine, 11 1, Kaga 2, Itabashi ku, Tokyo 173 8605, Japan
    Biochem Pharmacol 72:463-73. 2006
    ..These antimycotics may alleviate inflammatory infiltration in atopic dermatitis or psoriasis vulgaris by suppressing chemokine production...
  6. ncbi request reprint IL-17 suppresses TNF-alpha-induced CCL27 production through induction of COX-2 in human keratinocytes
    Naoko Kanda
    Department of Dermatology, Teikyo University, School of Medicine, Tokyo, Japan
    J Allergy Clin Immunol 116:1144-50. 2005
    ..IL-17 is released from activated memory T cells and modulates skin inflammation...
  7. ncbi request reprint Prostaglandin E2 enhances neurotrophin-4 production via EP3 receptor in human keratinocytes
    Naoko Kanda
    Department of Dermatology, Teikyo University, School of Medicine, Tokyo, Japan
    J Pharmacol Exp Ther 315:796-804. 2005
    ..PGE(2) may promote innervation in skin lesions with atopic dermatitis via the induction of neurotrophin-4...
  8. ncbi request reprint Regulatory roles of sex hormones in cutaneous biology and immunology
    Naoko Kanda
    Department of Dermatology, School of Medicine, Teikyo University, 11 1, Kaga 2, Itabashi ku, Tokyo 173 8605, Japan
    J Dermatol Sci 38:1-7. 2005
    ..These regulatory effects of sex steroids may be manipulated as therapeutic or prophylactic measures in psoriasis, aging, chronic wounds or granuloma pyogenicum...
  9. ncbi request reprint Prostaglandin E(2) suppresses CCL27 production through EP2 and EP3 receptors in human keratinocytes
    Naoko Kanda
    Department of Pathology, Teikyo University School of Medicine, Tokyo, Japan
    J Allergy Clin Immunol 114:1403-9. 2004
    ..CCL27 production by keratinocytes is enhanced in skin lesions from patients with atopic dermatitis or psoriasis vulgaris. It is suggested that prostaglandin E(2) (PGE(2)) regulates skin inflammation...
  10. ncbi request reprint 17beta-estradiol enhances the production of granulocyte-macrophage colony-stimulating factor in human keratinocytes
    Naoko Kanda
    Department of Dermatology, Teikyo University, School of Medicine, Kaga, Itabashi ku, Tokyo, Japan
    J Invest Dermatol 123:329-37. 2004
    ..These results suggest that E2 may enhance GM-CSF production via guanine nucleotide-binding protein-coupled membrane receptors and signaling cascade of PI-specific PLC/protein kinase Calpha/MEK/ERK...
  11. ncbi request reprint IL-18 enhances IFN-gamma-induced production of CXCL9, CXCL10, and CXCL11 in human keratinocytes
    Naoko Kanda
    Department of Dermatology, Teikyo University School of Medicine, Tokyo, Japan
    Eur J Immunol 37:338-50. 2007
    ..IL-18 may act as a pro-inflammatory cytokine in these dermatoses and thus is a candidate therapeutic target...
  12. ncbi request reprint Leukotriene B(4) enhances tumour necrosis factor-alpha-induced CCL27 production in human keratinocytes
    N Kanda
    Department of Dermatology, School of Medicine, Teikyo University, Tokyo, Japan
    Clin Exp Allergy 37:1074-82. 2007
    ..A lipid mediator leukotriene B(4) (LTB(4)) may be involved in the development of these allergic dermatoses. LTB(4) acts on cell surface G-protein-coupled receptors, BLT1 and BLT2...
  13. doi request reprint IL-12, IL-23, and IL-27 enhance human beta-defensin-2 production in human keratinocytes
    Naoko Kanda
    Department of Dermatology, Teikyo University, School of Medicine, Tokyo, Japan
    Eur J Immunol 38:1287-96. 2008
    ..STAT3 and STAT1 are involved in the effects of IL-12 and IL-27, respectively. Thus, IL-12, IL-23, and IL-27 may promote cutaneous antimicrobial defense and inflammation via hBD-2...
  14. doi request reprint Leptin enhances human beta-defensin-2 production in human keratinocytes
    Naoko Kanda
    Department of Dermatology, Teikyo University School of Medicine, 11 1 Kaga 2 Itabashi Ku, Tokyo 173 8605, Japan
    Endocrinology 149:5189-98. 2008
    ..Leptin may promote cutaneous antimicrobial defense, inflammation, and wound repair via hBD-2...
  15. doi request reprint Prolactin enhances basal and IL-17-induced CCL20 production by human keratinocytes
    Naoko Kanda
    Department of Dermatology, Teikyo University School of Medicine, Tokyo, Japan
    Eur J Immunol 39:996-1006. 2009
    ..PRL may promote Th17 infiltration into psoriatic lesions via CCL20...
  16. doi request reprint Prostaglandin D2 induces the production of human beta-defensin-3 in human keratinocytes
    Naoko Kanda
    Department of Dermatology, Teikyo University School of Medicine, 11 1, Kaga 2, Itabashi ku, Tokyo 173 8605, Japan
    Biochem Pharmacol 79:982-9. 2010
    ..Prostaglandin D(2) may promote cutaneous antimicrobial activity via hBD-3...
  17. doi request reprint Increased serum leucine, leucine-37 levels in psoriasis: positive and negative feedback loops of leucine, leucine-37 and pro- or anti-inflammatory cytokines
    Naoko Kanda
    Department of Dermatology, Teikyo University School of Medicine, Tokyo, Japan
    Hum Immunol 71:1161-71. 2010
    ..In controls, negative feedback by LL-37 on TNF-α, IL-1β, IL-22, and IL-6 may exist. In both groups, negative feedback by LL-37 on IL-17 may exist. LL-37 may act as an effector and regulator...
  18. doi request reprint The antimycotic drugs itraconazole and terbinafine hydrochloride induce the production of human β-defensin-3 in human keratinocytes
    Naoko Kanda
    Department of Dermatology, Teikyo University, School of Medicine, 11 1, Kaga 2, Itabashi ku, Tokyo, Japan
    Immunobiology 216:497-504. 2011
    ..The induction of hBD-3 in keratinocytes is another possible mechanism for the antimycrobial effects of these drugs, which may augment the cutaneous defense activity against infection...
  19. doi request reprint Visfatin enhances CXCL8, CXCL10, and CCL20 production in human keratinocytes
    N Kanda
    Department of Dermatology, Teikyo University School of Medicine, 2 11 1, Kaga, Itabashi ku, Tokyo 173 8605, Japan
    Endocrinology 152:3155-64. 2011
    ..Visfatin may induce the infiltration of type 1 or type 17 helper T cells or neutrophils to the skin via chemokine induction and thus link metabolic syndromes to psoriasis...
  20. ncbi request reprint 17beta-estradiol stimulates the growth of human keratinocytes by inducing cyclin D2 expression
    Naoko Kanda
    Department of Dermatology, Teikyo University, School of Medicine, Itabashi ku, Tokyo, Japan
    J Invest Dermatol 123:319-28. 2004
    ..These results suggest that E2 may stimulate the growth of keratinocytes by inducing cyclin D2 expression via CREB phosphorylation by protein kinase A, dependent on cAMP. These effects of E2 may be mediated via cell surface GPR30...
  21. ncbi request reprint Histamine enhances the production of granulocyte-macrophage colony-stimulating factor via protein kinase Calpha and extracellular signal-regulated kinase in human keratinocytes
    Naoko Kanda
    Department of Dermatology, Teikyo University, School of Medicine, Tokyo, Japan
    J Invest Dermatol 122:863-72. 2004
    ..These results suggest that histamine may enhance GM-CSF production at transcriptional and posttranscriptional levels via H1 receptor, protein kinase Calpha and extracellular signal-regulated kinase...
  22. ncbi request reprint Anti-mycotics suppress interleukin-4 and interleukin-5 production in anti-CD3 plus anti-CD28-stimulated T cells from patients with atopic dermatitis
    N Kanda
    Department of Dermatology, Teikyo University, School of Medicine, Japan
    J Invest Dermatol 117:1635-46. 2001
    ....
  23. ncbi request reprint 17beta-estradiol enhances vascular endothelial growth factor production and dihydrotestosterone antagonizes the enhancement via the regulation of adenylate cyclase in differentiated THP-1 cells
    Naoko Kanda
    Department of Dermatology, Teikyo University, School of Medicine, Tokyo, Japan
    J Invest Dermatol 118:519-29. 2002
    ..These results suggest that 17beta-estradiol enhances VEGF production while dihydrotestosterone antagonizes the effect of 17beta-estradiol via up- or downregulation of adenylate cyclase in differentiated THP-1...
  24. ncbi request reprint Gangliosides GD1b, GT1b, and GQ1b suppress the growth of human melanoma by inhibiting interleukin-8 production: the inhibition of adenylate cyclase
    N Kanda
    Department of Dermatology, Teikyo University, School of Medicine, Tokyo, Japan
    J Invest Dermatol 117:284-93. 2001
    ..The data indicate that GD1b, GT1b, and GQ1b may suppress the growth of melanoma by inhibiting interleukin-8 production via the inhibition of adenylate cyclase...
  25. ncbi request reprint 17beta-estradiol, progesterone, and dihydrotestosterone suppress the growth of human melanoma by inhibiting interleukin-8 production
    N Kanda
    Department of Dermatology, Teikyo University, School of Medicine, Itabashi ku, Tokyo, Japan
    J Invest Dermatol 117:274-83. 2001
    ..These data suggest that 17beta-estradiol, progesterone, and dihydrotestosterone suppress the growth of melanoma by inhibiting interleukin-8 production in a receptor-dependent manner...
  26. ncbi request reprint Regulatory roles of adenylate cyclase and cyclic nucleotide phosphodiesterases 1 and 4 in interleukin-13 production by activated human T cells
    N Kanda
    Department of Dermatology, Teikyo University, School of Medicine, 11 1, Kaga 2, Itabashi ku, Tokyo 173 8605, Japan
    Biochem Pharmacol 62:495-507. 2001
    ..Both the time-dependent increase and decrease of cAMP may be required for IL-13 production...
  27. ncbi request reprint Intracellular 3',5'-adenosine cyclic monophosphate level regulates house dust mite-induced interleukin-13 production by T cells from mite-sensitive patients with atopic dermatitis
    N Kanda
    Department of Dermatology, Teikyo University, School of Medicine, Tokyo, Japan
    J Invest Dermatol 116:3-11. 2001
    ..These events are required for interleukin-13 response Dermatophagoides pteronyssinus...
  28. ncbi request reprint Gangliosides GD1b, GT1b, and GQ1b enhance IL-2 and IFN-gamma production and suppress IL-4 and IL-5 production in phytohemagglutinin-stimulated human T cells
    N Kanda
    Department of Dermatology, School of Medicine, Teikyo University, Tokyo, Japan
    J Immunol 166:72-80. 2001
    ..These results suggest that GD1b, GT1b, and GQ1b may enhance Th1 cytokine production while suppressing Th2 production by inhibiting adenylate cyclase activity...
  29. ncbi request reprint Ganglioside GD1a enhances immunoglobulin production by human peripheral blood mononuclear cells
    N Kanda
    Department of Dermatology, Teikyo University, School of Medicine, Tokyo, Japan
    Exp Hematol 28:672-9. 2000
    ..These results suggest that GD1a may indirectly enhance B cell Ig production in whole PBMC by increasing IL-6 and IL-10 production of monocytes via promoting Ca(2)+/CaM-dependent PDE activity...
  30. ncbi request reprint Ketoconazole suppresses prostaglandin E(2)-induced cyclooxygenase-2 expression in human epidermoid carcinoma A-431 cells
    Naoko Kanda
    Department of Dermatology, Teikyo University, School of Medicine, 11 1 Kaga 2, Itabashi ku, Tokyo 173 8605, Japan
    J Invest Dermatol 119:174-81. 2002
    ..These results suggest that ketoconazole may suppress prostaglandin E2-induced cyclooxygenase-2 expression by inhibiting the cyclic adenosine monophosphate signal in A-431, and stress its anti-cancer effect...
  31. ncbi request reprint Ketoconazole suppresses interleukin-4 plus anti-CD40-induced IgE class switching in surface IgE negative B cells from patients with atopic dermatitis
    Naoko Kanda
    Department of Dermatology, Teikyo University, School of Medicine, Tokyo, Japan
    J Invest Dermatol 119:590-9. 2002
    ..These results suggest that ketoconazole may suppress interleukin-4 plus anti-CD40-induced B cell IgE class switching by inhibiting cAMP signal, and stress its prophylactic effects on allergic diseases...
  32. ncbi request reprint Cyclooxygenase-2 inhibitor enhances whereas prostaglandin E2 inhibits the production of interferon-induced protein of 10 kDa in epidermoid carcinoma A431
    Naoko Kanda
    Department of Dermatology, Teikyo University, School of Medicine, Tokyo, Japan
    J Invest Dermatol 119:1080-9. 2002
    ..The results also suggest that NS398 may restore IP-10 synthesis by preventing PGE2 production in A431 and thus may be therapeutically useful for skin cancer...
  33. ncbi request reprint 17beta-estradiol inhibits oxidative stress-induced apoptosis in keratinocytes by promoting Bcl-2 expression
    Naoko Kanda
    Teikyo University, Tokyo, Japan
    J Invest Dermatol 121:1500-9. 2003
    ..These effects of 17beta-estradiol may be mediated via membrane GPR30...
  34. ncbi request reprint Histamine enhances the production of nerve growth factor in human keratinocytes
    Naoko Kanda
    Department of Dermatology, Teikyo University, School of Medicine, 11 1 Kaga 2, Itabashi ku, Tokyo 173 8605, Japan
    J Invest Dermatol 121:570-7. 2003
    ..These effects may be mediated by the H1-receptor-induced signaling cascade of phospholipase C-protein kinase C-mitogen-activated protein kinase kinase 1-extracellular signal-regulated kinase...
  35. ncbi request reprint 17Beta-estradiol inhibits MCP-1 production in human keratinocytes
    Naoko Kanda
    Department of Dermatology, Teikyo University, School of Medicine, Tokyo, Japan
    J Invest Dermatol 120:1058-66. 2003
    ..A/B region and intact activation function 2 of ERbeta may be responsible for the effects of E2...
  36. ncbi request reprint 17beta-estradiol inhibits the production of RANTES in human keratinocytes
    Naoko Kanda
    Department of Dermatology, Teikyo University, School of Medicine, Tokyo, Japan
    J Invest Dermatol 120:420-7. 2003
    ..These results suggest that 17beta-estradiol-bound estrogen receptor may inhibit nuclear factor kappaB-dependent transcription of RANTES gene by competing with p65 for limiting amounts of CREB-binding protein...
  37. ncbi request reprint 17beta-estradiol inhibits the production of interferon-induced protein of 10 kDa by human keratinocytes
    Naoko Kanda
    Department of Dermatology, Teikyo University, School of Medicine, Tokyo, Japan
    J Invest Dermatol 120:411-9. 2003
    ....
  38. ncbi request reprint Histamine inhibits the production of interferon-induced protein of 10 kDa in human squamous cell carcinoma and melanoma
    Naoko Kanda
    Department of Dermatology, Teikyo University, School of Medicine, 11 1, Kaga 2, Itabashi ku, Tokyo 173 8605, Japan
    J Invest Dermatol 119:1411-9. 2002
    ....
  39. ncbi request reprint Substance P enhances the production of interferon-induced protein of 10 kDa by human keratinocytes in synergy with interferon-gamma
    Naoko Kanda
    Department of Dermatology, Teikyo University, School of Medicine, Tokyo, Japan
    J Invest Dermatol 119:1290-7. 2002
    ..These effects of substance P may be mediated via phospholipase C activation, intra-cellular Ca2+ signal, and reactive oxygen intermediates...
  40. ncbi request reprint 17Beta-estradiol enhances the production of nerve growth factor in THP-1-derived macrophages or peripheral blood monocyte-derived macrophages
    Naoko Kanda
    Department of Dermatology, Teikyo University, School of Medicine, Tokyo, Japan
    J Invest Dermatol 121:771-80. 2003
    ..These results suggest that E2 may enhance nerve growth factor production by inducing c-Fos expression via cyclic adenosine monophosphate signal in macrophages. These effects may be mediated via GPR30...
  41. pmc Regulatory B cells suppress imiquimod-induced, psoriasis-like skin inflammation
    Koichi Yanaba
    1 Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    J Leukoc Biol 94:563-73. 2013
    ..The present findings provide direct evidence that B10 cells regulate imiquimod-induced skin inflammation and offer insights into regulatory B cell-based therapies for the treatment of psoriasis. ..
  42. doi request reprint Association of the numbers of CD163(+) cells in lesional skin and serum levels of soluble CD163 with disease progression of cutaneous T cell lymphoma
    Makoto Sugaya
    Department of Dermatology, University of Tokyo, Tokyo, Japan
    J Dermatol Sci 68:45-51. 2012
    ..Tumor-associated macrophages exhibit M2 phenotype, whose presence has been associated with poor prognosis in various tumors...
  43. doi request reprint IL-22, but not IL-17, dominant environment in cutaneous T-cell lymphoma
    Tomomitsu Miyagaki
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Clin Cancer Res 17:7529-38. 2011
    ..In this study, we investigated expression levels of T(H)22- and T(H)17-related molecules in lesional skin and sera isolated from patients with CTCL...
  44. doi request reprint P2Y6 receptor signaling pathway mediates inflammatory responses induced by monosodium urate crystals
    Hideya Uratsuji
    Department of Dermatology, University of Tokyo, Tokyo, Japan
    J Immunol 188:436-44. 2012
    ..Thus, these results indicate that the P2Y(6) receptor signaling pathway may be a potential therapeutic target for MSU-associated inflammatory diseases, such as tophaceous gout...
  45. doi request reprint Semaphorin 7A on keratinocytes induces interleukin-8 production by monocytes
    Masahiro Kamata
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    J Dermatol Sci 62:176-82. 2011
    ..Semaphorin 7A (Sema7A) expressed on activated T cells stimulates cytokine production in monocytes through its receptor, α1β1 integrin...
  46. doi request reprint Possible roles of IL-27 in the pathogenesis of psoriasis
    Sayaka Shibata
    Faculty of Medicine, Department of Dermatology, University of Tokyo, Tokyo, Japan
    J Invest Dermatol 130:1034-9. 2010
    ..These results indicate that IL-27 may promote the onset of psoriasis, while it may simultaneously attenuate the expanded inflammation in this disease. Our results implicate potential therapeutic effects of IL-27 for psoriasis...
  47. pmc CD19 expression in B cells regulates atopic dermatitis in a mouse model
    Koichi Yanaba
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Am J Pathol 182:2214-22. 2013
    ..Furthermore, the present findings may have implications for B-cell-targeted therapies for the treatment of atopic dermatitis...
  48. doi request reprint Lichen planus-like lesions as the first manifestation of adult T-cell leukaemia/lymphoma
    Hayakazu Sumida
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Acta Derm Venereol 93:461-3. 2013
    ..We report here a rare case of a 62-year-old Japanese woman with smouldering-type ATLL, first manifested by lichen planus-like skin lesions on the lower leg. This case report highlights the multiplicity of skin manifestations in ATLL. ..
  49. doi request reprint ICAM-1 deficiency exacerbates sarcoid-like granulomatosis induced by Propionibacterium acnes through impaired IL-10 production by regulatory T cells
    Masahiro Kamata
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Am J Pathol 183:1731-9. 2013
    ..Our results indicate that ICAM-1 is imperative for inducing regulatory T cells to produce IL-10 in vivo, which would prevent granuloma formation...
  50. doi request reprint Visfatin enhances the production of cathelicidin antimicrobial peptide, human β-defensin-2, human β-defensin-3, and S100A7 in human keratinocytes and their orthologs in murine imiquimod-induced psoriatic skin
    Carren S Hau
    Department of Dermatology, Teikyo University School of Medicine, Tokyo, Japan
    Am J Pathol 182:1705-17. 2013
    ..Visfatin may potentiate the development of psoriasis via antimicrobial peptides...