K Tanaka

Summary

Country: Japan

Publications

  1. ncbi Ultraviolet radiation-induced suppression of natural killer cell activity is enhanced in xeroderma pigmentosum group A (XPA) model mice
    H Miyauchi-Hashimoto
    Department of Dermatology, Kansai Medical University, Moriguchi, Osaka, Japan
    J Invest Dermatol 112:965-70. 1999
  2. ncbi Exacerbation of noise-induced hearing loss in mice lacking the glutamate transporter GLAST
    N Hakuba
    Department of Otolaryngology, Ehime University School of Medicine, Ehime 791 0295, Japan
    J Neurosci 20:8750-3. 2000
  3. ncbi The NEDD8 system is essential for cell cycle progression and morphogenetic pathway in mice
    K Tateishi
    Department of Molecular Oncology, Tokyo Metropolitan Institute of Medical Science, Bunkyo ku, Tokyo 113 8613, Japan
    J Cell Biol 155:571-9. 2001
  4. ncbi Preclinical relevance of dosing time for the therapeutic index of gemcitabine-cisplatin
    X M Li
    INSERM E 354 Chronothérapeutique des Cancers and Université Paris XI, Hopital Paul Brousse, 14 16 Avenue Paul Vaillant Couturier, Villejuif 94800, France
    Br J Cancer 92:1684-9. 2005
  5. ncbi Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1
    K Tanaka
    Department of Degenerative Neurological Diseases, National Institute of Neuroscience, Kodaira, Tokyo 187, Japan
    Science 276:1699-702. 1997
  6. ncbi Structure and functional expression of the cloned mouse neuronal high-affinity glutamate transporter
    Y Maeno-Hikichi
    Department of Degenerative Neurological Diseases, National Institute of Neuroscience, NCNP, Ogawahigashi, Kodaira, Japan
    Brain Res Mol Brain Res 48:176-80. 1997
  7. ncbi Motor discoordination and increased susceptibility to cerebellar injury in GLAST mutant mice
    K Watase
    Department of Degenerative Neurological Diseases, National Institute of Neuroscience, Kodaira, Tokyo, Japan
    Eur J Neurosci 10:976-88. 1998
  8. ncbi Functions of the two glutamate transporters GLAST and GLT-1 in the retina
    T Harada
    Department of Degenerative Neurological Diseases, National Institute of Neuroscience, NCNP, Kodaira, Tokyo 187 8502, Japan
    Proc Natl Acad Sci U S A 95:4663-6. 1998
  9. ncbi Genomic organization, promoter analysis, and chromosomal localization of the gene for the mouse glial high-affinity glutamate transporter Slc1a3
    T Hagiwara
    Department of Degenerative Neurological Diseases, National Institute of Neuroscience, NCNP, Kodaira, 187, Japan
    Genomics 33:508-15. 1996
  10. ncbi Expression of a glutamate transporter subtype, EAAT4, in the developing human cerebellum
    M Itoh
    Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan
    Brain Res 767:265-71. 1997

Collaborators

Detail Information

Publications64

  1. ncbi Ultraviolet radiation-induced suppression of natural killer cell activity is enhanced in xeroderma pigmentosum group A (XPA) model mice
    H Miyauchi-Hashimoto
    Department of Dermatology, Kansai Medical University, Moriguchi, Osaka, Japan
    J Invest Dermatol 112:965-70. 1999
    ..Moreover, the present study suggests that the enhanced ultraviolet-induced impairment of natural killer function could be partially involved in cancer development...
  2. ncbi Exacerbation of noise-induced hearing loss in mice lacking the glutamate transporter GLAST
    N Hakuba
    Department of Otolaryngology, Ehime University School of Medicine, Ehime 791 0295, Japan
    J Neurosci 20:8750-3. 2000
    ..These findings also provide further support for the hypothesis that IHCs use glutamate as a neurotransmitter...
  3. ncbi The NEDD8 system is essential for cell cycle progression and morphogenetic pathway in mice
    K Tateishi
    Department of Molecular Oncology, Tokyo Metropolitan Institute of Medical Science, Bunkyo ku, Tokyo 113 8613, Japan
    J Cell Biol 155:571-9. 2001
    ..Thus, the NEDD8 system is essential for the regulation of protein degradation pathways involved in cell cycle progression and morphogenesis, possibly through the function of the Cul family proteins...
  4. ncbi Preclinical relevance of dosing time for the therapeutic index of gemcitabine-cisplatin
    X M Li
    INSERM E 354 Chronothérapeutique des Cancers and Université Paris XI, Hopital Paul Brousse, 14 16 Avenue Paul Vaillant Couturier, Villejuif 94800, France
    Br J Cancer 92:1684-9. 2005
    ..02). The optimal schedule would correspond to the delivery of gemcitabine upon awakening and cisplatin near mid-activity in cancer patients...
  5. ncbi Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1
    K Tanaka
    Department of Degenerative Neurological Diseases, National Institute of Neuroscience, Kodaira, Tokyo 187, Japan
    Science 276:1699-702. 1997
    ..These effects can be attributed to elevated levels of residual glutamate in the brains of these mice...
  6. ncbi Structure and functional expression of the cloned mouse neuronal high-affinity glutamate transporter
    Y Maeno-Hikichi
    Department of Degenerative Neurological Diseases, National Institute of Neuroscience, NCNP, Ogawahigashi, Kodaira, Japan
    Brain Res Mol Brain Res 48:176-80. 1997
    ..In situ hybridization in mouse brain sections showed that the mRNA is expressed densely and selectively in cell bodies of Purkinje cells...
  7. ncbi Motor discoordination and increased susceptibility to cerebellar injury in GLAST mutant mice
    K Watase
    Department of Degenerative Neurological Diseases, National Institute of Neuroscience, Kodaira, Tokyo, Japan
    Eur J Neurosci 10:976-88. 1998
    ..These results indicate that GLAST plays active roles both in the cerebellar climbing fibre synapse formation and in preventing excitotoxic cerebellar damage after acute brain injury...
  8. ncbi Functions of the two glutamate transporters GLAST and GLT-1 in the retina
    T Harada
    Department of Degenerative Neurological Diseases, National Institute of Neuroscience, NCNP, Kodaira, Tokyo 187 8502, Japan
    Proc Natl Acad Sci U S A 95:4663-6. 1998
    ..These results demonstrate that GLAST is required for normal signal transmission between photoreceptors and bipolar cells and that both GLAST and GLT-1 play a neuroprotective role during ischemia in the retina...
  9. ncbi Genomic organization, promoter analysis, and chromosomal localization of the gene for the mouse glial high-affinity glutamate transporter Slc1a3
    T Hagiwara
    Department of Degenerative Neurological Diseases, National Institute of Neuroscience, NCNP, Kodaira, 187, Japan
    Genomics 33:508-15. 1996
    ....
  10. ncbi Expression of a glutamate transporter subtype, EAAT4, in the developing human cerebellum
    M Itoh
    Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan
    Brain Res 767:265-71. 1997
    ..EAAT4 immunoreactivity may be related to the dendritic arborization of cells in the molecular layer...
  11. ncbi An in-frame deletion in peripheral myelin protein-22 gene causes hypomyelination and cell death of the Schwann cells in the new Trembler mutant mice
    J G Suh
    Department of Animal Models for Human Disease, National Institute of Neuroscience, NCNP, Kodaira, Tokyo, Japan
    Neuroscience 79:735-44. 1997
    ..The latter phenotype is discussed in conjunction with the disruption of an intracellular transport system and subsequent cell death...
  12. ncbi Molecular cloning of two glutamate transporter subtypes from mouse brain
    Y Mukainaka
    Department of Degenerative Neurological Diseases, National Institute of Neuroscience, Tokyo, Japan
    Biochim Biophys Acta 1244:233-7. 1995
    ..9% amino acid sequence identity with the rat GLT1 and MEAAC1 has 89.3% identity with the rabbit EAAC1. MEAAC1 mRNA was expressed in brain, lung, kidney and skeletal muscle, whereas expression of MGLT1 was restricted to brain...
  13. ncbi Amygdala-kindled and pentylenetetrazole-induced seizures in glutamate transporter GLAST-deficient mice
    T Watanabe
    Department of Neuropsychiatry, Faculty of Medicine, Kagawa Medical University, 1750 1, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Brain Res 845:92-6. 1999
    ..These results indicate that GLAST is one of factors determining seizure susceptibility...
  14. ncbi Glutamate does not play a major role in controlling bone growth
    C Gray
    Department of Anatomy, University College London, United Kingdom
    J Bone Miner Res 16:742-9. 2001
    ..These data suggest that glutamate does not play a major role in controlling bone growth...
  15. ncbi Glutamate transporter GLT-1 is transiently localized on growing axons of the mouse spinal cord before establishing astrocytic expression
    K Yamada
    Department of Anatomy, Hokkaido University School of Medicine, Sapporo 060 8638, Japan
    J Neurosci 18:5706-13. 1998
    ....
  16. ncbi Requirement of appropriate glutamate concentrations in the synaptic cleft for hippocampal LTP induction
    H Katagiri
    Department of Neurophysiology, Faculty of Medicine, University of Tokyo, Tokyo 113 0033, Japan
    Eur J Neurosci 14:547-53. 2001
    ..These findings suggest that GLT-1 plays critical roles in LTP induction, as well as in short-term potentiation, through regulation of extracellular levels of glutamate, which enables appropriate NMDA receptor activation...
  17. ncbi Glutamate transporter GLAST is expressed in the radial glia-astrocyte lineage of developing mouse spinal cord
    T Shibata
    Department of Anatomy, Hokkaido University School of Medicine, Sapporo 060, Japan
    J Neurosci 17:9212-9. 1997
    ....
  18. ncbi Disruption of the epilepsy KCNQ2 gene results in neural hyperexcitability
    H Watanabe
    Pharmaceutical Frontier Research Laboratories, Japan Tobacco, Yokohama Department of Neurology, School of Medicine, Keio University, Tokyo, Japan
    J Neurochem 75:28-33. 2000
    ..These data indicate that the decreased expression of KCNQ2 might cause a hyperexcitability of the CNS, which accounts for the mechanism of BFNC...
  19. ncbi Changes in expression and distribution of the glutamate transporter EAAT4 in developing mouse Purkinje cells
    K Yamada
    Department of Anatomy, Hokkaido University School of Medicine, Sapporo, Japan
    Neurosci Res 27:191-8. 1997
    ....
  20. ncbi Down-regulated expression of glutamate transporter GLAST in Purkinje cell-associated astrocytes of reeler and weaver mutant cerebella
    M Fukaya
    Department of Anatomy, Hokkaido University School of Medicine, Sapporo, Japan
    Neurosci Res 34:165-75. 1999
    ....
  21. ncbi Ataxia and epileptic seizures in mice lacking type 1 inositol 1,4,5-trisphosphate receptor
    M Matsumoto
    Department of Molecular Neurobiology, University of Tokyo, Japan
    Nature 379:168-71. 1996
    ....
  22. ncbi Cloning and expression of a glutamate transporter from mouse brain
    K Tanaka
    Laboratory for Neural Networks, Institute of Physical and Chemical Research, RIKEN, Saitama, Japan
    Neurosci Lett 159:183-6. 1993
    ..The cDNA sequence predicts a protein of 543 amino acids with 6 potential transmembrane domains. Northern blot analysis indicates the mRNA encoding the glutamate transporter is expressed both in the brain and in peripheral tissues...
  23. ncbi Dynamic changes in expression of glutamate transporter mRNAs in developing brain
    T Shibata
    Department of Urology, Hokkaido University School of Medicine, Sapporo, Japan
    Neuroreport 7:705-9. 1996
    ..These dynamic developmental regulations suggest that the glutamate transporter not only regulates the excitatory synaptic transmission at mature stages, but might also be intimately involved in the brain development...
  24. ncbi Inhibition of glutamate transporter by theanine enhances the therapeutic efficacy of doxorubicin
    T Sugiyama
    School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, 422 8526, Shizuoka, Japan
    Toxicol Lett 121:89-96. 2001
    ..We revealed the novel mechanism of enhancement of the antitumor efficacy of DOX via the inhibition of glutamate transporters by theanine...
  25. ncbi Importance of DNA repair in carcinogenesis: evidence from transgenic and gene targeting studies
    T Ishikawa
    Department of Pathology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, 113 0033, Tokyo, Japan
    Mutat Res 477:41-9. 2001
    ..These studies, thus, provided convincing evidence that XPA mice are also sensitive to carcinogenesis in organs other than the skin...
  26. ncbi Deletion of lolB, encoding an outer membrane lipoprotein, is lethal for Escherichia coli and causes accumulation of lipoprotein localization intermediates in the periplasm
    K Tanaka
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan
    J Bacteriol 183:6538-42. 2001
    ..Taken together, these results indicate that LolB is the first example of an essential lipoprotein for E. coli and that its depletion inhibits the upstream reactions of lipoprotein trafficking...
  27. ncbi Inducible nitric oxide synthase deficiency does not affect the susceptibility of mice to atherosclerosis but increases collagen content in lesions
    X L Niu
    Department of Physiology, School of Medicine, Tokai University, Isehara, Kanagawa, Japan
    Circulation 103:1115-20. 2001
    ..Although endothelial nitric oxide synthase (NOS) is antiatherogenic, the role of inducible NOS (iNOS) in the development of atherosclerosis is not established...
  28. ncbi Xeroderma pigmentosum group A gene action as a protection factor against 4-nitroquinoline 1-oxide-induced tongue carcinogenesis
    F Ide
    Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, Tokyo 113 0033, Japan
    Carcinogenesis 22:567-72. 2001
    ..Our results clearly demonstrate that the NER gene XPA acts as a defensive factor against 4NQO-induced tongue carcinogenesis in vivo...
  29. ncbi Acute rejection of orthotopic corneal xenografts in mice depends on CD4(+) T cells and self-antigen-presenting cells
    K Tanaka
    Department of Ophthalmology, Yokohama City University of Medicine, Japan
    Invest Ophthalmol Vis Sci 42:2878-84. 2001
    ..These results strongly suggest that rejection occurs exclusively through the indirect pathway of T-cell activation...
  30. ncbi Dwarfism and early death in mice lacking C-type natriuretic peptide
    H Chusho
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto 606 8507, Japan
    Proc Natl Acad Sci U S A 98:4016-21. 2001
    ..This study demonstrates that CNP acts locally as a positive regulator of endochondral ossification in vivo and suggests its pathophysiological and therapeutic implication in some forms of skeletal dysplasia...
  31. ncbi Long-term acceptance of allografts by in vivo gene transfer of regulatable adenovirus vector containing CTLA4IgG and loxP
    M Takehara
    Division of Molecular Immunology, Institute for Genetic Medicine, Hokkaido University, Sapporo 060-0815, Japan
    Hum Gene Ther 12:415-26. 2001
    ..More importantly, we also demonstrated that the long-term acceptance of allografts was achieved after the termination of CTLA4IgG expression, while the immune response against adenovirus was restored...
  32. ncbi A novel DNA vaccine based on ubiquitin-proteasome pathway targeting 'self'-antigens expressed in melanoma/melanocyte
    M Zhang
    Department of Microbiology and Immunology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Japan
    Gene Ther 12:1049-57. 2005
    ....
  33. ncbi S100 beta protein: the preoperative new clinical indicator of brain damage in patients with fulminant hepatic failure
    S Shiotani
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Transplant Proc 36:2713-6. 2004
    ..0 microg/L. Serum S100 beta levels correlated with the degree of brain edema of FHF. It has the potential to be a new clinical, noninvasive indicator of brain damage due to FHF...
  34. ncbi Syenergistic effect of 15-deoxyspergualin with costimulation blockade on alloimmune response
    N Shirasugi
    Department of Surgery, Teikyo University, Tokyo, Japan
    Transplant Proc 36:2446-7. 2004
    ..In this study, we investigate the ability of DSG with CB to inhibit a naive alloimmune responses...
  35. ncbi Role of nucleotide- and base-excision repair in genotoxin-induced neuronal cell death
    G E Kisby
    Center for Research on Occupational and Environmental Toxicology CROET, Oregon Health Sciences University, Portland, OR 97239, USA
    DNA Repair (Amst) 3:617-27. 2004
    ..These studies demonstrate that BER and NER are required to protect neurons from genotoxin-induced cell death...
  36. ncbi Distributions of two chicken bombesin receptors, bombesin receptor subtype-3.5 (chBRS-3.5) and gastrin-releasing peptide receptor (chGRP-R) mRNAS in the chicken telencephalon
    F Maekawa
    Department of Life Science, Graduate School of Science and Technology, Kobe University, Kobe 657 8501, Japan
    Neuroscience 125:569-82. 2004
    ..5 mRNA. This result suggests that the endogenous ligands for chBRS-3.5 were likely BN-like peptides produced in the pallium...
  37. ncbi Ictal magnetoencephalographic discharges from elementary visual hallucinations of status epilepticus
    M Oishi
    Department of Neurosurgery, National Nishi Niigata Central Hospital, 1 14 1 Masago, Niigata 950 2085, Japan
    J Neurol Neurosurg Psychiatry 74:525-7. 2003
    ..To report the rare opportunity to study ictal magnetoencephalography (MEG) in a 26 year old man with simple partial status epilepticus that presented as elementary visual hallucinations (EVHs) in the right upper visual field...
  38. ncbi A new neuromodulatory pathway with a glial contribution mediated via A(2a) adenosine receptors
    T Nishizaki
    Department of Physiology, Hyogo College of Medicine, Nishinomiya, Japan
    Glia 39:133-47. 2002
    ..The results of the present study thus represent a novel neuromodulatory pathway with a glial contribution, bearing both inhibition of GLT-1 function and stimulation of glial glutamate release, as mediated via A(2a) adenosine receptors...
  39. ncbi Microtubule network facilitates nuclear targeting of human cytomegalovirus capsid
    K Ogawa-Goto
    Department of Pathology, National Institute of Infectious Diseases, Shinjuku, Tokyo 162 8640, Japan
    J Virol 77:8541-7. 2003
    ....
  40. ncbi Cytogenetic and cellular events during radiation-induced thymic lymphomagenesis in the p53 heterozygous (+/-) B10 mouse
    K Tanaka
    Radiation Hazards Research Group, National Institute of Radiological Sciences, 4 9 1, Anagawa, Inage, Chiba 263 8555, Japan
    Int J Radiat Biol 78:165-72. 2002
    ..Cellular and cytogenetic events in radiation-induced thymic lymphomagenesis were investigated in the p53 heterozygous (+/-) mouse following a single dose of whole-body irradiation...
  41. ncbi The inducible nitric oxide synthase locus confers protection against aerogenic challenge of both clinical and laboratory strains of Mycobacterium tuberculosis in mice
    C A Scanga
    Departments of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Infect Immun 69:7711-7. 2001
    ..tuberculosis. This protective role of RNI is essential for the control of infection established by either intravenous or aerogenic challenge...
  42. ncbi Beta 3 integrins regulate lymphocyte migration and cytokine responses in heart transplant rejection
    A Lacy-Hulbert
    Howard Hughes Medical Institute, Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA
    Am J Transplant 7:1080-90. 2007
    ..Hence we provide strong mechanistic evidence supporting previous genetic studies, demonstrate the involvement of beta 3 integrins in both acute and chronic rejection and identify beta 3 as a new target for immunosuppressive therapy...
  43. ncbi Role of nitric oxide synthase type 2 in acute infection with murine cytomegalovirus
    S Noda
    Department of Infectious Diseases, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    J Immunol 166:3533-41. 2001
    ..It was thus concluded that the NOS2-mediated antiviral activity of macrophages via NO plays a protective role against MCMV infection at an early and late stage of the infection...
  44. ncbi The mouse genes encoding the third pair of beta-type proteasome subunits regulated reciprocally by IFN-gamma: structural comparison, chromosomal localization, and analysis of the promoter
    M Hayashi
    Department of Biochemistry, Hokkaido University School of Medicine, Sapporo, Japan
    J Immunol 159:2760-70. 1997
    ..Besides the Psmb7 gene previously mapped to chromosome 2, a truncated processed pseudogene, designated Psmb7-ps, was identified and mapped to chromosome X...
  45. ncbi Clarification of the structural and functional features of the osmoregulated kdp operon of Escherichia coli
    A Sugiura
    Laboratory of Microbiology, School of Agriculture, Nagoya University, Japan
    Mol Microbiol 6:1769-76. 1992
    ..e. in addition to them, a cis-acting sequence located upstream of the -35 region was essential for full activation of the promoter. This upstream sequence was demonstrated to be the target site for the trans-acting activator, KdpE...
  46. ncbi PA28 subunits of the mouse proteasome: primary structures and chromosomal localization of the genes
    E Kandil
    Department of Biochemistry, Hokkaido University School of Medicine, Sapporo 060, Japan
    Immunogenetics 46:337-44. 1997
    ..It appears that the IFN-gamma-inducible alpha- and beta-subunits emerged by gene duplication from a gamma-subunit-like precursor...
  47. ncbi Chromosomal localization of the proteasome Z subunit gene reveals an ancient chromosomal duplication involving the major histocompatibility complex
    M Kasahara
    Department of Biochemistry, Hokkaido University School of Medicine, Sapporo, Japan
    Proc Natl Acad Sci U S A 93:9096-101. 1996
    ..3 and 9q33-q34). These observations have implications in understanding the genomic organization of the present-day MHC and offer insights into the origin of the MHC...
  48. ncbi Expression cloning of a rat glutamate transporter
    K Tanaka
    Laboratory for Neural Network, Institute of Physical and Chemical Research RIKEN, Saitama, Japan
    Neurosci Res 16:149-53. 1993
    ..The glutamate transporter mRNA is expressed in both the brain and the peripheral tissues at different levels...
  49. ncbi The Saccharomyces cerevisiae MSI4 gene encodes the yeast counterpart of component A of Rab geranylgeranyltransferase
    K Fujimura
    Department of Biology, Faculty of Science, University of Tokyo, Japan
    J Biol Chem 269:9205-12. 1994
    ..We propose that the MSI4 gene product is a yeast counterpart of component A of Rab geranylgeranyltransferase that is essential for Ypt1p to localize on membranes...
  50. ncbi Cloning and expression of a human glutamate transporter
    H Kawakami
    Third Department of Internal Medicine, Hiroshima University School of Medicine, Japan
    Biochem Biophys Res Commun 199:171-6. 1994
    ..The cDNA sequence predicts a protein of 542 amino acids that is highly homologous to the congeneric proteins from rat and mouse brains. RNA blotting analyses revealed the expression both in the brain and in peripheral tissues...
  51. ncbi Localization of the gene (SLC1A3) encoding human glutamate transporter (GluT-1) to 5p13 by fluorescence in situ hybridization
    S Takai
    Department of Genetics, International Medical Center of Japan, Tokyo
    Cytogenet Cell Genet 69:209-10. 1995
    ..Chromosomal location of the human glutamate transporter, hGluT-1, gene (SLC1A3) was determined by fluorescence in situ hybridization. SLC1A3 was mapped to chromosome 5p13...
  52. ncbi A showdomycin-resistant mutant of Escherichia coli K-12 with altered nucleoside transport character
    Y Komatsu
    Biochim Biophys Acta 288:390-403. 1972
  53. ncbi Splice acceptor site mutation of the transporter associated with antigen processing-1 gene in human bare lymphocyte syndrome
    H Furukawa
    Department of Research, Japanese Red Cross Central Blood Center, Tokyo 150 0012, Japan
    J Clin Invest 103:755-8. 1999
    ..In addition, class I heavy chains (HCs) did not form the normal complex with tapasin in the endoplasmic reticulum (ER) of the cells of our patient...
  54. ncbi Identification of metastasis-promoting sequences in the mouse laminin alpha 1 chain
    Y Kuratomi
    National Institute of Dental and Craniofacial Research, NIH, Bethesda, Maryland, 20892, USA
    Exp Cell Res 249:386-95. 1999
    ..Thus, laminin-1 has multiple active sites in the globular domains of the short arm which promote migration and metastasis of B16-F10 cells...
  55. ncbi Protective effects of sunscreening agents on photocarcinogenesis, photoaging, and DNA damage in XPA gene knockout mice
    S Horiki
    Department of Dermatology, Kansai Medical University, 10 15, Fumizono cho, Moriguchi, Osaka, 570 8506, Japan
    Arch Dermatol Res 292:511-8. 2000
    ..The XPA model mouse is a useful animal for the evaluation of the photoprotective ability of sunscreens because photoresponses, even chronic changes, can be easily and quickly induced experimentally...
  56. ncbi T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-gamma
    H Takayanagi
    Department of Immunology, Faculty of Medicine and Graduate School of Medicine, University of Tokyo, Japan
    Nature 408:600-5. 2000
    ..Our results may offer a therapeutic approach to treat the inflammation-induced tissue breakdown...
  57. ncbi A half-type ABC transporter TAPL is highly conserved between rodent and man, and the human gene is not responsive to interferon-gamma in contrast to TAP1 and TAP2
    A Kobayashi
    Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565 0871, Japan
    J Biochem 128:711-8. 2000
    ..3. Furthermore, the transcription of TAPL gene is not responsive to interferon-gamma, in contrast to TAP1 and TAP2. These results indicate that the gene regulation of TAPL is different from those of TAP1 and TAP2...
  58. ncbi Mycobacterium tuberculosis infection in complement receptor 3-deficient mice
    C Hu
    Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    J Immunol 165:2596-602. 2000
    ..The data also indicate that absence of CR3 does not alter disease course in either the relatively resistant C57BL/6 or the relatively susceptible BALB/c strains of mice...
  59. ncbi Inducible nitric oxide synthase knockout mouse macrophages disclose prooxidant effect of interferon-gamma on low-density lipoprotein oxidation
    X L Niu
    Department of Physiology, Tokai University, Isehara, Kanagawa, 259 1193, Japan
    Nitric Oxide 4:363-71. 2000
    ..We conclude that IFN-gamma promotes macrophage-mediated LDL oxidation by stimulating superoxide and thiol production under conditions where iNOS-catalyzed NO release is restricted...
  60. ncbi Delay of DNA-adduct repair and severe toxicity in xeroderma pigmentosum group A gene (XPA) deficient mice treated with 2-amino-1-methyl-6-phenyl-imidazo [4,5-b] pyridine (PhIP)
    K Imaida
    1st Department of Pathology, Nagoya City University Medical School, Japan
    Cancer Lett 150:63-9. 2000
    ....
  61. ncbi Subcellular localization of proteasomes and their regulatory complexes in mammalian cells
    P Brooks
    Department of Biochemistry, University of Bristol, School of Medical Sciences, Bristol BS8 1TD, U K
    Biochem J 346:155-61. 2000
    ....
  62. ncbi Possible involvement of enhanced prostaglandin E2 production in the photosensitivity in xeroderma pigmentosum group A model mice
    K Kuwamoto
    Department of Dermatology, Kansai Medical University, Moriguchi, Osaka, Japan
    J Invest Dermatol 114:241-6. 2000
    ..The induced production of PGE2 may be involved in the enhanced inflammation and immunosuppression caused by UV radiation in XPA-deficient mice and XP patients...
  63. ncbi Facilitation of NMDAR-independent LTP and spatial learning in mutant mice lacking ryanodine receptor type 3
    A Futatsugi
    Shionogi Institute for Medical Science, Shionogi and Company, Ltd, Osaka, Japan
    Neuron 24:701-13. 1999
    ..These results suggest that in wild-type mice, in contrast to the excitatory role of Ca2+ influx, RyR3-mediated intracellular Ca2+ ([Ca2+]i) release from endoplasmic reticulum (ER) may inhibit hippocampal LTP and spatial learning...
  64. ncbi [Two cases of hemorrhagic shock and encephalopathy syndrome]
    T Minato
    Department of Pediatrics, Hyogo Prefectural Awaji Hospital
    No To Hattatsu 24:71-7. 1992
    ..in 1983. The etiology of this disease is currently unknown, and its prognosis is poor. The relationship between this disease and rotavirus should be examined in future studies...