H Sakurai

Summary

Affiliation: Tanabe Seiyaku Co
Country: Japan

Publications

  1. ncbi request reprint Phosphorylation-dependent activation of TAK1 mitogen-activated protein kinase kinase kinase by TAB1
    H Sakurai
    Discovery Research Laboratory, Tanabe Seiyaku Co, Ltd, 16 89 Kashima 3 chome, Yodogawa ku, 532 8505, Osaka, Japan
    FEBS Lett 474:141-5. 2000
  2. ncbi request reprint IkappaB kinases phosphorylate NF-kappaB p65 subunit on serine 536 in the transactivation domain
    H Sakurai
    Discovery Research Laboratory, Tanabe Seiyaku Co, Ltd, 16 89 Kashima 3 chome, Yodogawa ku, Osaka 532 8505, Japan
    J Biol Chem 274:30353-6. 1999
  3. ncbi request reprint Functional interactions of transforming growth factor beta-activated kinase 1 with IkappaB kinases to stimulate NF-kappaB activation
    H Sakurai
    Discovery Research Laboratory, Tanabe Seiyaku Co, Ltd, 16 89 Kashima 3 chome, Yodogawa ku, Osaka 532 8505, Japan
    J Biol Chem 274:10641-8. 1999
  4. ncbi request reprint Insulinomimetic bis(maltolato)zinc(II) complex: blood glucose normalizing effect in KK-A(y) mice with type 2 diabetes mellitus
    Y Yoshikawa
    Department of Chemistry, Graduate School of Science, Osaka City University, 3-3-138 Sugimoto, Sumiyoshi-ku, Osaka, 558-8585, Japan
    Biochem Biophys Res Commun 281:1190-3. 2001
  5. ncbi request reprint TGF-beta-activated kinase 1 stimulates NF-kappa B activation by an NF-kappa B-inducing kinase-independent mechanism
    H Sakurai
    Lead Generation Research Laboratory, Tanabe Seiyaku Co, Ltd, Osaka, Japan
    Biochem Biophys Res Commun 243:545-9. 1998
  6. ncbi request reprint Domon L, an immunopotentiating agent, acts as an NF-kappaB activator
    S Tanaka
    Lead Generation Research Laboratory, Tanabe Seiyaku Co, Ltd, Osaka, Japan
    J Vet Med Sci 59:575-9. 1997
  7. ncbi request reprint Cell to cell interaction between mesangial cells and macrophages induces the expression of monocyte chemoattractant protein-1 through nuclear factor-kappaB activation
    Y Hisada
    Discovery Research Laboratory, Tanabe Seiyaku Co, Ltd, Yodogawa ku, Osaka, 532 8505, Japan
    Biochem Biophys Res Commun 269:309-16. 2000
  8. ncbi request reprint Amelioration of insulin resistance in diabetic ob/ob mice by a new type of orally active insulin-mimetic vanadyl complex: bis(1-oxy-2-pyridinethiolato)oxovanadium(IV) with VO(S(2)O(2)) coordination mode
    S Takeshita
    Medicinal Biology Research Laboratories, Fujisawa Pharmaceutical Co, Ltd, Kashima, Yodogawa-ku, Osaka 532-8514, Japan
    J Inorg Biochem 85:179-86. 2001
  9. ncbi request reprint New insulinomimetic zinc(II) complexes of alpha-amino acids and their derivatives with Zn(N2O2) coordination mode
    Y Yoshikawa
    Department of Chemistry, Graduate School of Science, Osaka City University, Osaka, Japan
    Chem Pharm Bull (Tokyo) 49:652-4. 2001
  10. pmc Angiotensin II plays a pathogenic role in immune-mediated renal injury in mice
    Y Hisada
    Discovery Research Laboratory, Tanabe Seiyaku Co, Ltd, Kashima, Osaka 532 8505, Japan
    J Clin Invest 103:627-35. 1999

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Phosphorylation-dependent activation of TAK1 mitogen-activated protein kinase kinase kinase by TAB1
    H Sakurai
    Discovery Research Laboratory, Tanabe Seiyaku Co, Ltd, 16 89 Kashima 3 chome, Yodogawa ku, 532 8505, Osaka, Japan
    FEBS Lett 474:141-5. 2000
    ..These results demonstrated that the association between the kinase domain of TAK1 and the C-terminal TAB1 triggered the phosphorylation-dependent TAK1 activation mechanism...
  2. ncbi request reprint IkappaB kinases phosphorylate NF-kappaB p65 subunit on serine 536 in the transactivation domain
    H Sakurai
    Discovery Research Laboratory, Tanabe Seiyaku Co, Ltd, 16 89 Kashima 3 chome, Yodogawa ku, Osaka 532 8505, Japan
    J Biol Chem 274:30353-6. 1999
    ..Furthermore, activation of IKKs by NF-kappaB-inducing kinase induced phosphorylation of p65 in vivo. Our finding, together with previous observations, suggests dual roles for IKK complex in the regulation of NF-kappaB.IkappaB complex...
  3. ncbi request reprint Functional interactions of transforming growth factor beta-activated kinase 1 with IkappaB kinases to stimulate NF-kappaB activation
    H Sakurai
    Discovery Research Laboratory, Tanabe Seiyaku Co, Ltd, 16 89 Kashima 3 chome, Yodogawa ku, Osaka 532 8505, Japan
    J Biol Chem 274:10641-8. 1999
    ..These results demonstrated a novel signaling pathway to NF-kappaB activation through TAK1 in which TAK1 may act as a regulatory kinase of IKKs...
  4. ncbi request reprint Insulinomimetic bis(maltolato)zinc(II) complex: blood glucose normalizing effect in KK-A(y) mice with type 2 diabetes mellitus
    Y Yoshikawa
    Department of Chemistry, Graduate School of Science, Osaka City University, 3-3-138 Sugimoto, Sumiyoshi-ku, Osaka, 558-8585, Japan
    Biochem Biophys Res Commun 281:1190-3. 2001
    ..The blood glucose level was maintained in the normal range during administration of the Zn(Mal)(2) complex for 14 days and improvements in the glucose tolerance were confirmed by an oral glucose tolerance test...
  5. ncbi request reprint TGF-beta-activated kinase 1 stimulates NF-kappa B activation by an NF-kappa B-inducing kinase-independent mechanism
    H Sakurai
    Lead Generation Research Laboratory, Tanabe Seiyaku Co, Ltd, Osaka, Japan
    Biochem Biophys Res Commun 243:545-9. 1998
    ..A dominant negative mutant of NIK did not inhibit TAK1-induced NF-kappa B activation. These results suggest that TAK1 induces NF-kappa B activation through a novel NIK-independent signaling pathway...
  6. ncbi request reprint Domon L, an immunopotentiating agent, acts as an NF-kappaB activator
    S Tanaka
    Lead Generation Research Laboratory, Tanabe Seiyaku Co, Ltd, Osaka, Japan
    J Vet Med Sci 59:575-9. 1997
    ..The spleen cells of rats treated with Domon L produced much more NO when stimulated with LPS + IFN gamma than spleen cells of untreated rats. These results suggest that Domon L acts as an anti-infectious agent via NF-kappaB activation...
  7. ncbi request reprint Cell to cell interaction between mesangial cells and macrophages induces the expression of monocyte chemoattractant protein-1 through nuclear factor-kappaB activation
    Y Hisada
    Discovery Research Laboratory, Tanabe Seiyaku Co, Ltd, Yodogawa ku, Osaka, 532 8505, Japan
    Biochem Biophys Res Commun 269:309-16. 2000
    ..Because MCP-1 is suggested to play an important role in glomerulonephritis, this novel cell to cell interaction between the MCs and Mo/Mo could be important in glomerulonephritis...
  8. ncbi request reprint Amelioration of insulin resistance in diabetic ob/ob mice by a new type of orally active insulin-mimetic vanadyl complex: bis(1-oxy-2-pyridinethiolato)oxovanadium(IV) with VO(S(2)O(2)) coordination mode
    S Takeshita
    Medicinal Biology Research Laboratories, Fujisawa Pharmaceutical Co, Ltd, Kashima, Yodogawa-ku, Osaka 532-8514, Japan
    J Inorg Biochem 85:179-86. 2001
    ....
  9. ncbi request reprint New insulinomimetic zinc(II) complexes of alpha-amino acids and their derivatives with Zn(N2O2) coordination mode
    Y Yoshikawa
    Department of Chemistry, Graduate School of Science, Osaka City University, Osaka, Japan
    Chem Pharm Bull (Tokyo) 49:652-4. 2001
    ..The improvement of diabetes mellitus was confirmed with the oral glucose tolerance test...
  10. pmc Angiotensin II plays a pathogenic role in immune-mediated renal injury in mice
    Y Hisada
    Discovery Research Laboratory, Tanabe Seiyaku Co, Ltd, Kashima, Osaka 532 8505, Japan
    J Clin Invest 103:627-35. 1999
    ..These results suggest the involvement of AII in immune-mediated renal injuries...
  11. ncbi request reprint Characterization of capsid-modified adenovirus vectors containing heterologous peptides in the fiber knob, protein IX, or hexon
    S Kurachi
    Laboratory of Gene Transfer and Regulation, National Institute of Biomedical Innovation, Osaka, Japan
    Gene Ther 14:266-74. 2007
    ..These comparative analyses, together with a simple construction method for each modified Ad vector, could provide basic information for the generation of capsid-modified Ad vectors...
  12. ncbi request reprint Functional correlation among Gal11, transcription factor (TF) IIE, and TFIIH in Saccharomyces cerevisiae. Gal11 and TFIIE cooperatively enhance TFIIH-mediated phosphorylation of RNA polymerase II carboxyl-terminal domain sequences
    H Sakurai
    School of Health Sciences, Faculty of Medicine, Kanazawa University, 5 11 80 Kodatsuno, Kanazawa, Ishikawa 920 0942, Japan
    J Biol Chem 273:9534-8. 1998
    ....
  13. pmc Protein phosphatase 2A interacts with and directly dephosphorylates RelA
    J Yang
    Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2175, USA
    J Biol Chem 276:47828-33. 2001
    ..and Richmond, A. (2001) Cancer Res. 61, 4901-4909) could be due, at least in part, to the deficiency of PP2A, which exhibits decreased dephosphorylation of NF-kappa B/RelA...
  14. ncbi request reprint Molecular cloning and characterization of a copper chaperone for copper/zinc superoxide dismutase from the rat
    M Hiromura
    Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University, 5 Nakauchi cho, Misasagi, Yamashina ku, Kyoto, 607 6414, Japan
    Biochem Biophys Res Commun 275:394-400. 2000
    ..The binding of rCCS to Cu/Zn SOD was analyzed by GST column binding assay, and the domain II of rCCS was found to be essential for binding to Cu/Zn SOD, which in turn activates Cu/Zn SOD...
  15. ncbi request reprint Identification of pleiotrophin as a mesenchymal factor involved in ureteric bud branching morphogenesis
    H Sakurai
    Department of Pediatrics, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0693, USA
    Development 128:3283-93. 2001
    ..We suggest that pleiotrophin could act as a key mesenchymally derived factor regulating branching morphogenesis of the ureteric bud and perhaps other embryonic epithelial structures...
  16. ncbi request reprint Involvement of laminin binding integrins and laminin-5 in branching morphogenesis of the ureteric bud during kidney development
    R Zent
    Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093 0693, USA
    Dev Biol 238:289-302. 2001
    ..These data may help to partially explain the renal phenotype seen in integrin alpha3 and alpha3/alpha6 subunit-deficient animals...
  17. ncbi request reprint Lysophosphatidylcholine increases the secretion of matrix metalloproteinase 2 through the activation of NADH/NADPH oxidase in cultured aortic endothelial cells
    N Inoue
    First Department of Internal Medicine, School of Medicine, Kobe University, 7-5-2 Kusunoki-cho, Chuo-ku, 650-0017, Kobe, Japan
    Atherosclerosis 155:45-52. 2001
    ..Our findings suggest that LPC might activate the endothelial NADH/NADPH oxidase to enhance superoxide production, and it might, in turn, enhance MMP-2 induction...
  18. ncbi request reprint Radicicol potentiates heat-induced cell killing in a human oesophageal cancer cell line: the Hsp90 chaperone complex as a new molecular target for enhancement of thermosensitivity
    T Akimoto
    Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3 39 22 Showa machi, Maebashi, Gunma 371 8511, Japan
    Int J Radiat Biol 80:483-92. 2004
    ..To examine the ability of a heat shock protein 90 (Hsp90) chaperone complex inhibitor, radicicol, to modify thermal response and heat-induced cell killing, and to clarify the underlining mechanisms...
  19. ncbi request reprint Alternative splicing and gene structure of the transforming growth factor beta-activated kinase 1
    C E Dempsey
    Functional Genomics Group, Division of Molecular and Genetic Medicine, University of Sheffield, Royal Hallamshire Hospital, Sheffield, UK
    Biochim Biophys Acta 1517:46-52. 2000
    ..Study of the relative levels of expression of the four splice variants showed significant variations between tissues. Our evidence suggests that the alternative splicing of the TAK1 mRNA may have important functional implications...
  20. pmc Selective inhibition of TNF-alpha-induced activation of mitogen-activated protein kinases and metastatic activities by gefitinib
    Y Ueno
    Division of Pathogenic Biochemistry, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Br J Cancer 92:1690-5. 2005
    ..These results suggest that the TNF-alpha signalling pathway is a possible target of gefitinib in suppressing the intrahepatic metastasis of hepatocellular carcinoma...
  21. ncbi request reprint Developmentally regulated expression of organic ion transporters NKT (OAT1), OCT1, NLT (OAT2), and Roct
    A Pavlova
    Renal, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Physiol Renal Physiol 278:F635-43. 2000
    ..These genes could also play important developmental roles independent of transport function...
  22. ncbi request reprint Purification of yeast histones competent for nucleosome assembly in vitro
    M Fukuma
    Division of Chemotherapy, Keio University School of Medicine, Tokyo, Japan
    Yeast 10:319-31. 1994
    ..The length of DNA fragment wrapping around a core histone particle and the molar ratio of histone components in an assembled nucleosome particle were estimated to be 150 +/- 10 bp long and H2A:H2B:H3:H4 = 1.0:0.9:0:9:1.0, respectively...
  23. pmc Analysis of the galactose signal transduction pathway in Saccharomyces cerevisiae: interaction between Gal3p and Gal80p
    T Suzuki-Fujimoto
    Department of Microbiology, Keio University School of Medicine, Japan
    Mol Cell Biol 16:2504-8. 1996
    ..Reexamination of the DNA sequence of GAL3 revealed several mistakes, including an extension at the 3' end of another predicted 97 amino acids...
  24. pmc The yeast GAL11 protein binds to the transcription factor IIE through GAL11 regions essential for its in vivo function
    H Sakurai
    Laboratory of Molecular Genetics, Keio University School of Medicine, Tokyo, Japan
    Proc Natl Acad Sci U S A 93:9488-92. 1996
    ..In light of these findings, we suggest that Gal11p stimulates promoter activity by enhancing an association of TFIIE with the preinitiation complex in the cell...
  25. ncbi request reprint Molecular assembly of RNA polymerase II from the fission yeast Schizosaccharomyces pombe: subunit-subunit contact network involving Rpb5
    T Miyao
    National Institute of Genetics, Department of Molecular Genetics, Mishima, Shizuoka, Japan
    Genes Cells 1:843-54. 1996
    ..Toward this ultimate goal, we analysed the topological arrangement of the putative subunits. Here we report a subunit-subunit contact network involving subunit 5 of the fission yeast Schizosaccharomyces pombe RNA polymerase II...
  26. ncbi request reprint Gene organization and protein sequence of the small subunits of Schizosaccharomyces pombe RNA polymerase II
    H Sakurai
    National Institute of Genetics, Department of Molecular Genetics, Shizuoka, Japan
    Gene 196:165-74. 1997
    ..Taken altogether, the gene organization and the predicted protein sequence have been determined for all 10 subunits of the S. pombe RNA polymerase II...
  27. ncbi request reprint Yeast Gal11 and transcription factor IIE function through a common pathway in transcriptional regulation
    H Sakurai
    School of Health Sciences, Faculty of Medicine, Kanazawa University, 5 11 80 Kodatsuno, Kanazawa, Ishikawa 920, Japan
    J Biol Chem 272:32663-9. 1997
    ..In a reconstituted cell-free system, Gal11 protein stimulated basal transcription in the presence of wild-type TFIIE. Such a stimulation was not seen in the presence of TFIIE-DeltaC...
  28. ncbi request reprint Identification of the gene and the protein of RNA polymerase II subunit 9 (Rpb9) from the fission yeast Schizosacharomyces pombe
    H Sakurai
    National Institute of Genetics, Department of Molecular Genetics, Shizuoka, Japan
    Gene 221:11-6. 1998
    ..After Western blot analysis using antibodies raised against the protein product of the newly isolated rpb9 gene, we found that the purified RNA polymerase II contains Rpb9...
  29. pmc The Rpb4 subunit of fission yeast Schizosaccharomyces pombe RNA polymerase II is essential for cell viability and similar in structure to the corresponding subunits of higher eukaryotes
    H Sakurai
    Department of Molecular Genetics, National Institute of Genetics, Mishima, Shizuoka 411 8540, Japan
    Mol Cell Biol 19:7511-8. 1999
    ..However, S. pombe Rpb4 is closer in certain molecular functions to S. cerevisiae RPB4 than the eukaryotic RPB4 homologues...
  30. ncbi request reprint Molecular cloning of rat ATX1 homologue protein
    M Hiromura
    Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University, 5 Nakauchi cho, Misasagi, Yamashina ku, Kyoto, 607 8414, Japan
    Biochem Biophys Res Commun 265:509-12. 1999
    ..Expression of rah1 cDNA complemented a null atx1 mutant strain in yeast. Thus, Rah1p was concluded to be a functional copper chaperone...
  31. ncbi request reprint Long-term in vitro suspension culture of Toxoplasma and HeLa cells
    H Sakurai
    Department of Veterinary Physiology, Obihiro University, Hokkaido, Japan
    Zentralbl Bakteriol Mikrobiol Hyg A 264:468-77. 1987
    ..9 X 10(9). The mean generation time of Toxoplasma organisms on the 0, 10, 20 and 30 day's cultivation was calculated approximately 7.4, 9.4, 9.3 and 7.8 h, respectively...