Keiji Tanaka


Country: Japan


  1. Okatsu K, Kimura M, Oka T, Tanaka K, Matsuda N. Unconventional PINK1 localization to the outer membrane of depolarized mitochondria drives Parkin recruitment. J Cell Sci. 2015;128:964-78 pubmed publisher
  2. Okatsu K, Koyano F, Kimura M, Kosako H, Saeki Y, Tanaka K, et al. Phosphorylated ubiquitin chain is the genuine Parkin receptor. J Cell Biol. 2015;209:111-28 pubmed publisher
    ..We thus propose that the phosphorylated ubiquitin chain functions as the genuine Parkin receptor for recruitment to depolarized mitochondria. ..
  3. Yoshida Y, Saeki Y, Tsuchiya H, Tanaka K. Detection of ubiquitination activity and identification of ubiquitinated substrates using TR-TUBE. Methods Enzymol. 2019;618:135-147 pubmed publisher
  4. Murata S, Takahama Y, Kasahara M, Tanaka K. The immunoproteasome and thymoproteasome: functions, evolution and human disease. Nat Immunol. 2018;19:923-931 pubmed publisher
    ..In this Review, we describe various aspects of these immunity-dedicated proteasomes, from their discovery to recent findings. ..
  5. Tanaka K. The proteasome: overview of structure and functions. Proc Jpn Acad Ser B Phys Biol Sci. 2009;85:12-36 pubmed
    ..Many questions, however, remain to be elucidated. ..
  6. Ohtake F, Saeki Y, Ishido S, Kanno J, Tanaka K. The K48-K63 Branched Ubiquitin Chain Regulates NF-?B Signaling. Mol Cell. 2016;64:251-266 pubmed publisher
  7. Tanaka K, Mizushima T, Saeki Y. The proteasome: molecular machinery and pathophysiological roles. Biol Chem. 2012;393:217-34 pubmed publisher
    ..Several studies have highlighted the importance of the proteasome in various intractable diseases that have been increasing in the aged society of the 21st century. ..
  8. Tanaka K, Matsuda N. Proteostasis and neurodegeneration: the roles of proteasomal degradation and autophagy. Biochim Biophys Acta. 2014;1843:197-204 pubmed publisher
    ..This article is part of a Special Issue entitled: Ubiquitin-Proteasome System. Guest Editors: Thomas Sommer and Dieter H. Wolf. ..
  9. Tsuchiya H, Ohtake F, Arai N, Kaiho A, Yasuda S, Tanaka K, et al. In Vivo Ubiquitin Linkage-type Analysis Reveals that the Cdc48-Rad23/Dsk2 Axis Contributes to K48-Linked Chain Specificity of the Proteasome. Mol Cell. 2017;66:488-502.e7 pubmed publisher
    ..Collectively, our results provide an overall picture of the ubiquitin network via UBD proteins and identify the Cdc48-Rad23/Dsk2 axis as a major route to the proteasome. ..

More Information


  1. Matsuda N, Kimura M, Queliconi B, Kojima W, Mishima M, Takagi K, et al. Parkinson's disease-related DJ-1 functions in thiol quality control against aldehyde attack in vitro. Sci Rep. 2017;7:12816 pubmed publisher
    ..We infer that a key to understanding the biological function of DJ-1 resides in its methylglyoxal-adduct hydrolase activity, which protects low-molecular thiols, including CoA, from aldehydes...
  2. Tsuchiya H, Burana D, Ohtake F, Arai N, Kaiho A, Komada M, et al. Ub-ProT reveals global length and composition of protein ubiquitylation in cells. Nat Commun. 2018;9:524 pubmed publisher
    ..Thus, the Ub-ProT method can contribute to our understanding of mechanisms regulating physiological ubiquitin chain lengths and composition. ..