Okatsu K, Kimura M, Oka T, Tanaka K, Matsuda N. Unconventional PINK1 localization to the outer membrane of depolarized mitochondria drives Parkin recruitment. J Cell Sci. 2015;128:964-78 pubmed publisher
Okatsu K, Koyano F, Kimura M, Kosako H, Saeki Y, Tanaka K, et al
. Phosphorylated ubiquitin chain is the genuine Parkin receptor. J Cell Biol. 2015;209:111-28 pubmed publisher
..We thus propose that the phosphorylated ubiquitin chain functions as the genuine Parkin receptor for recruitment to depolarized mitochondria. ..
Yoshida Y, Saeki Y, Tsuchiya H, Tanaka K. Detection of ubiquitination activity and identification of ubiquitinated substrates using TR-TUBE. Methods Enzymol. 2019;618:135-147 pubmed publisher
Murata S, Takahama Y, Kasahara M, Tanaka K. The immunoproteasome and thymoproteasome: functions, evolution and human disease. Nat Immunol. 2018;19:923-931 pubmed publisher
..In this Review, we describe various aspects of these immunity-dedicated proteasomes, from their discovery to recent findings. ..
Tanaka K. The proteasome: overview of structure and functions. Proc Jpn Acad Ser B Phys Biol Sci. 2009;85:12-36 pubmed
..Many questions, however, remain to be elucidated. ..
Ohtake F, Saeki Y, Ishido S, Kanno J, Tanaka K. The K48-K63 Branched Ubiquitin Chain Regulates NF-?B Signaling. Mol Cell. 2016;64:251-266 pubmed publisher
Tanaka K, Mizushima T, Saeki Y. The proteasome: molecular machinery and pathophysiological roles. Biol Chem. 2012;393:217-34 pubmed publisher
..Several studies have highlighted the importance of the proteasome in various intractable diseases that have been increasing in the aged society of the 21st century. ..
Tanaka K, Matsuda N. Proteostasis and neurodegeneration: the roles of proteasomal degradation and autophagy. Biochim Biophys Acta. 2014;1843:197-204 pubmed publisher
..This article is part of a Special Issue entitled: Ubiquitin-Proteasome System. Guest Editors: Thomas Sommer and Dieter H. Wolf. ..
Tsuchiya H, Ohtake F, Arai N, Kaiho A, Yasuda S, Tanaka K, et al
. In Vivo Ubiquitin Linkage-type Analysis Reveals that the Cdc48-Rad23/Dsk2 Axis Contributes to K48-Linked Chain Specificity of the Proteasome. Mol Cell. 2017;66:488-502.e7 pubmed publisher
..Collectively, our results provide an overall picture of the ubiquitin network via UBD proteins and identify the Cdc48-Rad23/Dsk2 axis as a major route to the proteasome. ..